A traditional Chinese medicine composition, preparation and application for treating liver disease of spleen-kidney yang deficiency type

Abstract

The application discloses a traditional Chinese medicine composition for treating liver diseases of the type of deficiency of the spleen and kidney yang, a preparation and application. The composition is composed of the following components in parts by weight: Hei Shun Pian 10-15 g, dried ginger 6-10 g, Dangshen 10-15 g, fried Baishu 15-20 g, Fuling 10-15 g, Zexie 10-15 g, Dangui 10-15 g, Baishao 10-15 g, Chizhi 6-10 g, Chenpi 6-10 g, Heye 10-12 g, Gegen 10-20 g, Chuanqiong 10-12 g, Foshou 12-15 g, Jiaoshanzha 10-15 g, Shengqu 10-15 g and Zhigancao 6-10 g. The traditional Chinese medicine composition has the core effects of warming and tonifying the spleen and kidney and warming the liver and removing stasis, and has exact and remarkable therapeutic effects on metabolic-related fatty liver diseases of the type of deficiency of the spleen and kidney yang.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition, preparation and application for treating liver disease of spleen and kidney yang deficiency type. Background Technology

[0002] Metabolic associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a chronic liver disease characterized by fatty degeneration after excluding excessive alcohol consumption and viral infections. It is caused by insulin resistance and nutritional excess in genetically susceptible individuals. The prevalence of MAFLD is increasing annually, exceeding 30% globally, and has now surpassed viral hepatitis to become the leading chronic liver disease in my country. As MAFLD progresses, the liver's resistance to nutrient excess and adipose tissue play a decisive role. With the progression of the disease, coupled with unhealthy lifestyle and dietary habits, liver fat gradually accumulates. MAFLD can evolve from mild fatty degeneration to metabolic associated steatohepatitis, liver fibrosis, and even cirrhosis and liver cancer, severely impacting patients' quality of life and imposing a heavy economic burden on society. Therefore, early intervention and treatment of MAFLD are crucial. Currently, there are three main treatments for MAFLD: First, medication, which primarily involves controlling the patient's weight, blood sugar, blood lipids, and blood pressure, and using hepatoprotective drugs such as silymarin, polyene phosphatidylcholine, and bicyclol to improve liver biochemical indicators. Second, lifestyle intervention, which mainly involves health education guiding patients to increase exercise and adjust their diet to gradually reverse fatty liver. Third, surgery. However, medication has limited efficacy, and drugs specifically for MASH are limited and expensive. Lifestyle interventions are time-consuming, difficult for most people to adhere to, and slow to show results. Surgical treatment requires patients to meet the criteria for weight loss and metabolism surgery. Therefore, the clinical efficacy often falls short of expectations.

[0003] With the acceleration of the modern life rhythm, unhealthy living habits such as staying up late, overthinking, abnormal work and rest, and being exposed to cold and drinking cold beverages, as well as the abuse of antibiotics and cold-natured drugs, are gradually depleting our yang qi, leading to an increasing number of people with qi deficiency and yang deficiency. In "Plain Questions of Huangdi Neijing", it is said that "Yang qi is like the sun in the sky. If it loses its place, one's lifespan will be shortened and one will not thrive." Professor Jiang Liyun believes that yang qi is the primary driving force of life activities. If yang qi is weak and the zang-fu organs are not warmed, the human body will get sick due to abnormal movement. The yang qi of the whole body comes from the kidney yang, which is the congenital yang, and the spleen yang is the acquired yang, relying on the supplementation of the kidney yang. The weaker the kidney yang, the insufficient fire of the mingmen, the spleen yang is not warmed, and the genuine yang in the kidney warms and nourishes, then the earth is thick, and the thick earth enables yang qi to warm and circulate throughout the body. If the acquired spleen yang is insufficient, the earth qi of the spleen does not rise, and if the earth qi of the spleen does not rise, the earth qi of the stomach does not descend, and the production of qi and blood essence has no source and cannot nourish the congenital, and the kidney yang is also damaged. As the old gentleman Wu Peiheng elaborated in "Brief Introduction to Medicine": "If one only knows the acquired, it is like having an axis without a wheel; if one only knows the congenital, it is like having a wheel without an axis, and neither can achieve the function of the entire circular movement." The liver belongs to the wood element of the five elements theory, and its nature is also warm. The liver qi corresponds to spring, and it should rise, spread, and be smooth and unobstructed. Therefore, it is recorded in "Explanation of the Heavenly and Human in Four Sages' Heart Source": "The qi of wood is warm and keeps rising. When the accumulated warmth turns into heat, it transforms into fire." If the rising of liver wood is unfavorable, liver cold stagnates qi, and blood circulation is不畅, it will stagnate in the liver. As stated in "On the Pathogenesis of Zang-Fu Organs in Treatise on Blood Syndromes": "The nature of wood is mainly to dredge and disperse. When food qi enters the stomach, it entirely depends on the qi of liver wood to dredge and disperse it, and then the food and water can be transformed. If the clear yang of the liver does not rise, it cannot dredge and disperse food and water, and symptoms such as abdominal fullness and diarrhea are inevitable." Once spleen-kidney yang deficiency occurs, internal yin coldness prevails, the fire of the mingmen in the kidney is damaged and cannot warm and nourish the kidney water, resulting in excessive coldness of the kidney water; the spleen earth can originally control water, but now the kidney water is overly cold, and the genuine yang in the kidney cannot warm and nourish the acquired spleen yang, then the spleen yang is also damaged, the earth cannot control water, and instead is counterattacked by the cold water of the kidney, transforming from the original dampness of the spleen meridian, and the earth is trapped by dampness; the jueyin liver wood is born from the kidney water and grows in the spleen earth. Now, with water cold and earth damp, it counterattacks the wood, the wood of the liver does not rise, liver cold stagnates, qi and blood circulation is不畅, and cold coagulation stagnates to form masses. Its pathogenesis is mainly spleen-kidney yang deficiency and liver cold and wood stagnation as the secondary manifestation. As Huang Yuanyu said in "Explanation of the Six Qi in Four Sages' Heart Source - Jueyin Wind Wood": "In winter, water is in a state of closure and storage. Once it is stirred by the spring breeze, yang qi rises from the ground and the vitality begins to sprout. However, if the earth qi does not rise, it depends on the wood qi to promote its rise, and if the wood qi does not reach its full potential, it actually depends on the earth qi to achieve its smooth flow... When water is cold and earth is damp, it cannot promote the growth of wood qi, then wood stagnates and wind is generated." In clinical treatment, it is essential to "warm the fire to tonify the earth, warm the liver and eliminate masses", using the genuine fire of warming and tonifying the congenital kidney yang to warm and generate the liver wood of jueyin, and warming and nourishing the acquired spleen yang to warm and promote the smooth dredging of wood qi, achieving the warming of the kidney water of shaoyin, the dry transportation of the spleen earth of taiyin, and the warming and smoothness of the liver wood of jueyin, enabling the yang qi of the human body to circulate smoothly, qi and blood to flow, and the liver to be warmed and the masses to disappear. As stated in "Explanation of the Six Qi in Four Sages' Heart Source - Jueyin Wind Wood": "Generally speaking, jueyin wind wood is born from the kidney water and grows in the spleen earth. When water and earth are warm and harmonious, the liver wood flourishes, and the wood is calm and the wind is gentle." To sum up, metabolic associated fatty liver disease is closely related to spleen-kidney yang deficiency, and it is necessary to develop a traditional Chinese medicine composition that can treat metabolic associated fatty liver disease of spleen-kidney yang deficiency type.

[0004] Application content

[0005] The technical problem to be solved by this application is to provide a traditional Chinese medicine composition, preparation and application for treating liver disease of spleen and kidney yang deficiency type.

[0006] To solve the above-mentioned technical problems, the technical solution of this application is as follows:

[0007] A traditional Chinese medicine composition for treating liver disease of spleen and kidney yang deficiency type, comprising the following ingredients in parts by weight: 10-15g of dried aconite root slices, 6-10g of dried ginger, 10-15g of codonopsis root, 15-20g of stir-fried atractylodes macrocephala, 10-15g of poria cocos, 10-15g of alisma plantago-aquatica, 10-15g of angelica sinensis, 10-15g of white peony root, 6-10g of immature bitter orange, 6-10g of tangerine peel, 10-12g of lotus leaf, 10-20g of kudzu root, 10-12g of chuanxiong rhizome, 12-15g of citron, 10-15g of charred hawthorn, 10-15g of medicated leaven, and 6-10g of prepared licorice root.

[0008] Preferably, it is composed of the following ingredients in parts by weight: 15g of dried aconite root slices, 10g of dried ginger, 10g of codonopsis root, 15g of stir-fried atractylodes macrocephala, 15g of poria cocos, 15g of alisma plantago-aquatica, 15g of angelica sinensis, 15g of white peony root, 10g of immature bitter orange, 10g of dried tangerine peel, 10g of lotus leaf, 20g of kudzu root, 10g of chuanxiong rhizome, 15g of citron, 15g of charred hawthorn, 15g of medicated leaven, and 10g of prepared licorice root.

[0009] Based on the above scheme, this application also provides a preparation based on the above-mentioned traditional Chinese medicine composition, wherein the preparation is any one of decoction, granules, pills, tablets, capsules, ointment, syrup, powder and powder.

[0010] Based on the above scheme, this application also provides an application of the above-mentioned traditional Chinese medicine composition in the treatment of liver disease of spleen and kidney yang deficiency type.

[0011] Fang Yi's analysis:

[0012] Dried ginger is the principal ingredient. It is pungent and hot in nature and mainly enters the spleen, stomach, kidney, heart and lung meridians. It mainly enters the middle jiao, stops but does not move, and specifically disperses internal cold. It can assist aconite in clearing the meridians of cold and has a great power to restore yang. The "Pharmacopoeia" records that it "enters the kidney to dry dampness in the lower body". When the two are combined, they warm the innate to nourish the acquired, and warm the acquired to nourish the innate. Thus, the kidney water is warmed and the spleen earth is dried. Codonopsis pilosula, stir-fried Atractylodes macrocephala, Poria cocos, and Alisma plantago-aquatica are the assistant herbs. Codonopsis pilosula is sweet and neutral in nature, and enters the spleen and lung meridians. It can tonify the spleen and stomach, and strengthen the middle qi. The "Correct Interpretation of Materia Medica" states that it "strengthens the spleen without causing dryness, nourishes the stomach yin without causing dampness, moistens the lungs without causing coldness, nourishes the blood without being too greasy, invigorates the clear yang, and stimulates the middle qi without causing dryness." Stir-fried Atractylodes macrocephala is sweet and warm, tonifying deficiency, and bitter and warm, drying dampness. It can remove dampness from various meridians and regulate the spleen and stomach. When the earth element is strong, it can strengthen the spleen and stomach. It is the "first essential herb for tonifying the spleen and strengthening the spleen." Poria cocos is sweet, bland, and neutral in nature, and enters the heart, lung, spleen, and kidney meridians. It can strengthen the spleen, drain dampness, and tonify the middle qi. When dampness is removed, the middle qi is restored, and the clear and turbid are restored. Alisma plantago-aquatica is sweet, bland, and cold in nature, and enters the kidney and bladder meridians. Its blandness can drain dampness, and its function is particularly good at promoting water metabolism. It has the effects of promoting diuresis and draining dampness, resolving turbidity and lowering lipids, and purging kidney evil. When using tonifying herbs, it is necessary to also purge evil. When evil is removed, the tonifying herbs are more effective. Angelica sinensis, Paeonia lactiflora, Citrus aurantium, Citrus reticulata peel, Nelumbo nucifera leaf, Pueraria lobata, Ligusticum chuanxiong, Citrus medica, Crataegus pinnatifida (roasted), and Massa fermentata are used as adjuvant herbs. Angelica sinensis is sweet, pungent, and warm in nature, and enters the liver, heart, and spleen meridians. It enters the Spleen meridian of Foot Taiyin (as the spleen stores blood) and the Liver meridian of Foot Jueyin (as the liver stores blood). Its effect is warming, promoting blood circulation, warming the liver, dispelling cold, and relieving pain. Paeonia lactiflora is bitter, sour, and slightly cold in nature, and enters the liver and spleen meridians. It can follow the nature of liver wood growth in spring, and its sourness astringes liver yin, nourishing blood, softening the liver, and relieving pain. Citrus aurantium is bitter and pungent in taste. Its pungent and bitter purgative properties can promote blood circulation. Qi-regulating and dispersing stagnation, eliminating stagnant water, *Tangye Bencao* states: "Without Atractylodes macrocephala, dampness cannot be removed; without Citrus aurantium, stagnation cannot be eliminated." Tangerine peel, pungent and aromatic, warm and drying, can regulate qi, strengthen the spleen, and resolve dampness and phlegm. Lotus leaf and kudzu root can raise clear yang and lower turbid yin. *Bencao Zhengyi* records: "Kudzu root, with its mild flavor and aroma, is most effective in raising the clear yang qi of the spleen and stomach." Ligusticum chuanxiong, according to *Yuanyun de Guzhongyixue*, can replenish liver yang qi; its pungent and warm nature, its pungent aroma and dispersing properties can regulate qi and soothe the liver, while its warmth can warm and unblock blood vessels and nourish the liver. Buddha's hand, warm in nature, enters the liver, spleen, and stomach meridians; it can nourish the liver and warm the stomach, soothe the liver, regulate qi, and relieve pain. Roasted hawthorn, warm in nature, enters the spleen and stomach meridians and also the blood aspect of the liver; it can strengthen the spleen and stomach, disperse stagnant qi, resolve turbidity, and lower lipids. Shenqu, sweet and warm in nature, is good at assisting the middle jiao (earth element); it can strengthen the spleen and warm the stomach, resolve stagnation, regulate the middle jiao, and expel phlegm accumulation. Prepared licorice root is used as the guiding herb. It is a sweet and neutral herb that uniquely enters the spleen and stomach, tonifying the spleen and replenishing qi, harmonizing the effects of other herbs. When the spleen is tonified, it becomes more efficient in its function. The entire formula works together to warm the earth element, tonify the liver, and dispel stagnation.

[0013] The above technical solution has the following advantages:

[0014] The traditional Chinese medicine composition provided in this application possesses the core functions of warming and tonifying the spleen and kidneys, and warming the liver and eliminating stagnation. It has a definite and significant therapeutic effect on metabolic-related fatty liver disease (referred to as "liver stagnation" in traditional Chinese medicine) caused by spleen and kidney yang deficiency. Clinical studies show that this formula can effectively relieve symptoms of discomfort in the liver area, such as fullness and dull pain in the hypochondrium, while significantly improving symptoms of spleen and kidney yang deficiency, such as soreness and weakness in the lower back and knees, fatigue, and aversion to cold. It can also regulate digestive system disorders such as sticky and unformed stools. After standardized medication, patients' tongue appearance changed from pale and dark with a white and greasy coating to pale or thin white, and their pulse changed from deep and weak to deep, with a significant improvement in their overall physical condition. The formula is scientifically composed, taking into account the synergistic effects of warming yang, strengthening the spleen, regulating qi, promoting blood circulation, eliminating dampness, and promoting digestion, with a mild and lasting effect. No obvious adverse reactions were observed in clinical applications, demonstrating good safety and tolerability. Therefore, the traditional Chinese medicine composition of this application not only provides a safe and effective treatment option for metabolic-related fatty liver disease of spleen and kidney yang deficiency type, but also has the advantages of simple operation, good patient compliance, and suitability for long-term conditioning, and has high clinical promotion value and prospects for further development and application. Detailed Implementation

[0015] The specific embodiments of this application are further described below. It should be noted that these descriptions are for the purpose of aiding understanding of this application and do not constitute a limitation thereof. Furthermore, the technical features involved in the various embodiments of this application described below can be combined with each other as long as they do not conflict with each other.

[0016] Example 1

[0017] A traditional Chinese medicine composition for treating liver disease of spleen and kidney yang deficiency type, the composition comprising the following ingredients in parts by weight: 15g of dried aconite root slices, 10g of dried ginger, 10g of codonopsis root, 15g of stir-fried atractylodes macrocephala, 15g of poria cocos, 15g of alisma plantago-aquatica, 15g of angelica sinensis, 15g of white peony root, 10g of immature bitter orange, 10g of tangerine peel, 10g of lotus leaf, 20g of kudzu root, 10g of chuanxiong rhizome, 15g of citron, 15g of charred hawthorn, 15g of medicated leaven, and 10g of prepared licorice root.

[0018] The above composition may be formulated into a preparation by adding medically acceptable excipients as needed, and the preparation may be any one of decoction, granules, pills, tablets, capsules, ointment, syrup, powder, and powder.

[0019] Example 2

[0020] A traditional Chinese medicine composition for treating liver disease of spleen and kidney yang deficiency type, the composition consists of the following ingredients in parts by weight: 10g of dried aconite root slices, 6g of dried ginger, 10g of codonopsis root, 15g of stir-fried atractylodes macrocephala, 10g of poria cocos, 10g of alisma plantago-aquatica, 10g of angelica sinensis, 10g of white peony root, 6g of immature bitter orange, 6g of tangerine peel, 10g of lotus leaf, 10g of kudzu root, 10g of chuanxiong rhizome, 12g of citron, 10g of charred hawthorn, 10g of medicated leaven, and 6g of prepared licorice root.

[0021] The above composition may be formulated into a preparation by adding medically acceptable excipients as needed, and the preparation may be any one of decoction, granules, pills, tablets, capsules, ointment, syrup, powder, and powder.

[0022] Example 3

[0023] A traditional Chinese medicine composition for treating liver disease of spleen and kidney yang deficiency type, the composition consists of the following ingredients in parts by weight: 15g of dried aconite root slices, 10g of dried ginger, 15g of codonopsis root, 20g of stir-fried atractylodes macrocephala, 15g of poria cocos, 15g of alisma plantago-aquatica, 15g of angelica sinensis, 15g of white peony root, 10g of immature bitter orange, 10g of tangerine peel, 12g of lotus leaf, 20g of kudzu root, 12g of chuanxiong rhizome, 15g of citron, 15g of charred hawthorn, 15g of medicated leaven, and 10g of prepared licorice root.

[0024] The above composition may be formulated into a preparation by adding medically acceptable excipients as needed, and the preparation may be any one of decoction, granules, pills, tablets, capsules, ointment, syrup, powder, and powder.

[0025] Example 4

[0026] A traditional Chinese medicine composition for treating liver disease of spleen and kidney yang deficiency type, the composition consists of the following ingredients in parts by weight: 12g of dried aconite root slices, 8g of dried ginger, 12g of codonopsis root, 18g of stir-fried atractylodes macrocephala, 13g of poria cocos, 13g of alisma plantago-aquatica, 13g of angelica sinensis, 13g of white peony root, 88g of immature bitter orange, 88g of tangerine peel, 11g of lotus leaf, 15g of kudzu root, 11g of chuanxiong rhizome, 13g of citron, 12g of charred hawthorn, 12g of medicated leaven, and 8g of prepared licorice root.

[0027] The above composition may be formulated into a preparation by adding medically acceptable excipients as needed, and the preparation may be any one of decoction, granules, pills, tablets, capsules, ointment, syrup, powder, and powder.

[0028] To verify the effectiveness of the compositions of this application, clinical cases are provided, as follows:

[0029] Case 1

[0030] Patient Liu XX, male, 46 years old.

[0031] Chief complaint: Discomfort and fullness in the hypochondriac region for 1 month.

[0032] II. Medical History: The patient experienced fullness and discomfort in the hypochondriac region for one month, along with soreness and weakness in the lower back and knees, fatigue, and weakness, which worsened with exertion. The patient also experienced aversion to cold, normal appetite and sleep, sticky and unformed stools, and normal urination.

[0033] III. Physical examination: The patient is overweight with a body mass index (BMI) of 28.9 kg / m2. The tongue is pale and dark with a white and greasy coating, and the pulse is deep and weak.

[0034] IV. Auxiliary examination: Abdominal ultrasound showed fatty liver.

[0035] V. Traditional Chinese Medicine Diagnosis: Liver obstruction; Syndrome type: Spleen and Kidney Yang Deficiency Syndrome.

[0036] VI. Key points for diagnosis: Yang deficiency: soreness and weakness in the lower back and knees, fatigue and weakness, aversion to cold, pale and dark tongue, white and greasy tongue coating, and deep and weak pulse.

[0037] VII. Treatment: Warm and tonify the spleen and kidneys, warm the liver and eliminate stagnation.

[0038] VIII. Prescription (a traditional Chinese medicine composition for treating metabolic-related fatty liver disease of spleen and kidney yang deficiency type): 15g of dried aconite root slices (decocted first), 10g of dried ginger, 15g of codonopsis root, 20g of stir-fried atractylodes macrocephala, 15g of poria cocos, 15g of alisma plantago-aquatica, 15g of angelica sinensis, 15g of white peony root, 10g of immature bitter orange, 10g of tangerine peel, 10g of lotus leaf, 15g of kudzu root, 10g of chuanxiong rhizome, 15g of citron, 15g of charred hawthorn fruit, 10g of medicated leaven, and 10g of prepared licorice root. Usage: Decocted in water and taken orally, one dose every two days, for four consecutive weeks.

[0039] IX. Follow-up Visit (Therapeutic Effect): The fullness and discomfort in the hypochondriac region have been significantly reduced; the soreness and weakness in the lower back and knees, fatigue, and aversion to cold have significantly improved; bowel movements are formed. The tongue is pale and dark, with a thin, slightly greasy white coating; the pulse is deep. Continue the original prescription for 2 months to consolidate the effect.

[0040] Case 2

[0041] Patient Yang X, male, 39 years old.

[0042] Chief complaint: Dull pain in the hypochondrium for more than 2 weeks.

[0043] II. Medical History: Two weeks ago, the patient experienced dull pain in the hypochondrium, fatigue, weakness, soreness in the lower back and knees, aversion to cold, poor appetite, fair sleep, and normal bowel and bladder function.

[0044] III. Physical examination: The patient is overweight with a body mass index (BMI) of 29.3 kg / m2. The tongue is pale and dark with a white coating, and the pulse is deep and weak.

[0045] IV. Auxiliary examination: Abdominal ultrasound showed fatty liver.

[0046] V. Traditional Chinese Medicine Diagnosis: Liver obstruction; Syndrome type: Spleen and Kidney Yang Deficiency Syndrome.

[0047] VI. Key points for diagnosis: Yang deficiency: fatigue and weakness, soreness and weakness of the waist and knees, aversion to cold, pale and dark tongue, white coating, and deep and weak pulse.

[0048] VII. Treatment: Warm and tonify the spleen and kidneys, warm the liver and eliminate stagnation.

[0049] VIII. Prescription (a traditional Chinese medicine composition for treating metabolic-related fatty liver disease of spleen and kidney yang deficiency type): 15g of dried aconite root slices (decocted first), 10g of dried ginger, 10g of codonopsis root, 15g of stir-fried atractylodes macrocephala, 15g of poria cocos, 15g of alisma plantago-aquatica, 15g of angelica sinensis, 15g of white peony root, 10g of immature bitter orange, 10g of tangerine peel, 10g of lotus leaf, 20g of kudzu root, 10g of chuanxiong rhizome, 15g of citron, 15g of charred hawthorn fruit, 15g of medicated leaven, and 10g of prepared licorice root. Usage: Decocted in water and taken orally, one dose every two days, for four consecutive weeks.

[0050] 9. Follow-up visit (therapeutic effect): The dull pain in the hypochondrium has been significantly reduced, and the fatigue, weakness, soreness in the lower back and knees, and aversion to cold have significantly improved. The tongue is pale with a thin white coating, and the pulse is deep. Continue the original prescription for 2 months to consolidate the effect.

[0051] The traditional Chinese medicine composition provided in this application has significant beneficial effects in clinical application. Patients in Case 1 and Case 2 both had fatty liver of the spleen and kidney yang deficiency type (diagnosed as "liver stagnation" in traditional Chinese medicine), mainly manifested as distension or dull pain in the hypochondrium, soreness and weakness of the lower back and knees, fatigue, aversion to cold, sticky or unformed stools, pale and dark tongue, white and greasy tongue coating, and weak pulse. After taking this formula (containing prepared aconite root, dried ginger, codonopsis root, stir-fried atractylodes macrocephala, poria cocos, alisma plantago-aquatica, angelica sinensis, white peony root, immature bitter orange, tangerine peel, lotus leaf, kudzu root, chuanxiong rhizome, citron, charred hawthorn, medicated leaven, and prepared licorice root, decocted in water and taken once every two days for four weeks), both patients experienced significant relief from hypochondriac discomfort, marked improvement in symptoms of spleen and kidney yang deficiency such as soreness and weakness of the lower back and knees, fatigue, and aversion to cold, and normalized bowel movements (e.g., formed stools in Case 1). Their tongue and pulse also showed improvement. They continued treatment for two months to consolidate the therapeutic effect, and the efficacy remained stable. This formula has the effects of warming and tonifying the spleen and kidneys, warming the liver and eliminating stagnation. It is effective for metabolic fatty liver disease of spleen and kidney yang deficiency type, can effectively relieve clinical symptoms, improve physical condition, and has no obvious adverse reactions. It has good clinical promotion value.

[0052] The embodiments of this application have been described in detail above, but this application is not limited to the described embodiments. For those skilled in the art, various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of this application, and these variations still fall within the protection scope of this application.

Claims

1. A traditional Chinese medicine composition for treating liver disease of spleen-kidney yang deficiency, characterized in that It is composed of the following ingredients in parts by weight: 10-15g of dried aconite root slices, 6-10g of dried ginger, 10-15g of codonopsis root, 15-20g of stir-fried atractylodes macrocephala, 10-15g of poria cocos, 10-15g of alisma plantago-aquatica, 10-15g of angelica sinensis, 10-15g of white peony root, 6-10g of immature bitter orange, 6-10g of dried tangerine peel, 10-12g of lotus leaf, 10-20g of kudzu root, 10-12g of chuanxiong rhizome, 12-15g of citron, 10-15g of charred hawthorn, 10-15g of medicated leaven, and 6-10g of prepared licorice root.

2. The traditional Chinese medicine composition for treating liver disease of spleen-kidney yang deficiency according to claim 1, characterized in that It is composed of the following ingredients in parts by weight: 15g of dried aconite root slices, 10g of dried ginger, 10g of codonopsis root, 15g of stir-fried atractylodes macrocephala, 15g of poria cocos, 15g of alisma plantago-aquatica, 15g of angelica sinensis, 15g of white peony root, 10g of immature bitter orange, 10g of tangerine peel, 10g of lotus leaf, 20g of kudzu root, 10g of chuanxiong rhizome, 15g of citron, 15g of charred hawthorn, 15g of medicated leaven, and 10g of prepared licorice root.

3. A preparation based on the traditional Chinese medicine composition according to any one of claims 1-2, characterized in that: The preparation is any one of the following: decoction, granules, pills, tablets, capsules, ointment, syrup, powder, and granule.

4. The application of a traditional Chinese medicine composition based on any one of claims 1-2 in the treatment of liver disease of spleen and kidney yang deficiency type.