A phlegm-dissipating and meridian-unblocking food-homologous tablet composition for improving blood rheology and a preparation method thereof

Abstract

This invention discloses a medicinal and edible homologous tablet composition and its preparation method that soothes the liver, unblocks meridians, and improves blood rheology. Belonging to the field of functional food processing technology, this composition uses Gastrodia elata and earthworm protein as the principal ingredients, Polygonatum sibiricum, Dioscorea opposita, and Pueraria lobata as the assistant ingredients, supplemented with multiple adjuvant herbs and Eucommia ulmoides leaves, flavored with xylitol, following the principles of traditional Chinese medicine's principal, assistant, adjuvant, and guide formulation. This invention employs segmented low-temperature extraction and negative pressure concentration processes to produce tablets. All raw materials are selected from the list of medicinal and edible homologous ingredients, with no illegal additives, resulting in high retention of functional components and good absorption. This product is suitable for daily dietary conditioning in people with borderline high blood pressure and abnormal blood rheological indicators. It can relieve discomfort such as dizziness and headache, help improve human microcirculation, has high safety for consumption, can be mass-produced, and has good application prospects.

Description

Technical Field

[0001] This invention belongs to the field of functional food processing technology, specifically relating to a medicinal and edible homologous tablet composition that soothes the liver, unblocks the meridians, and improves blood rheology, and its preparation method. Background Technology

[0002] With changes in people's diet and lifestyle, middle-aged and elderly people are prone to sub-health conditions such as blood pressure fluctuations, blood viscosity, and poor microcirculation. At present, chemical drugs are often used to intervene in the clinical treatment of patients diagnosed with hypertension, but some people may experience intolerance such as dry cough, palpitations, and facial flushing after taking them.

[0003] Existing herbal dietary products of this type have many shortcomings: First, the formulas lack a systematic approach to formulation, resulting in poor synergistic effects among the ingredients; second, the commonly used high-temperature pulverization and drying processes easily destroy functional components such as gastrodin, active peptides, and flavonoids, leading to low absorption and utilization rates by the human body; and third, some products have lax control over raw materials, posing a food safety hazard due to the illegal addition of chemical blood pressure-lowering ingredients.

[0004] Currently, there is a lack of dietary tablet products on the market that have scientifically formulated combinations, compliant raw materials, use low-temperature processes to preserve active ingredients, and have no illegal additives. To address this, this invention selects raw materials such as Polygonatum sibiricum, Gastrodia elata, and earthworm protein, optimizes their proportions, and combines them with a segmented low-temperature extraction process to develop a conditioning tablet food with high safety and good ingredient retention, thus making up for the shortcomings of existing technologies. Summary of the Invention

[0005] The purpose of this invention is to provide a medicinal and edible homologous tablet composition that soothes the liver, unblocks the meridians, and improves blood rheology, as well as its preparation method, in order to solve the problem that existing herbal food formulations lack a systematic approach and that raw materials are difficult to work synergistically to improve human microcirculation.

[0006] To achieve the above objectives, the present invention provides a medicinal and edible homologous tablet composition that soothes the liver, unblocks the meridians, and improves blood rheology, comprising the following raw materials in parts by weight: Sweetening ingredient: 8-15 parts xylitol; The principal ingredient components are: 10-18 parts of Gastrodia elata and 5-12 parts of earthworm protein; The main ingredients are: Polygonatum sibiricum 12-20 parts, Dioscorea opposita 10-16 parts, and Pueraria lobata 9-15 parts. Adjuvant ingredients: 8-14 parts hawthorn, 7-13 parts mulberry leaf, 6-12 parts bitter melon, 7-14 parts cassia seed, 5-11 parts chrysanthemum; The main ingredients are: 8-15 parts of Cyclocarya paliurus leaves.

[0007] Preferably, the weight ratio of each raw material is as follows: xylitol 12 parts, gastrodia elata 15 parts, earthworm protein 8 parts, polygonatum 16 parts, yam 13 parts, kudzu root 12 parts, hawthorn 11 parts, mulberry leaf 10 parts, bitter melon 9 parts, cassia seed 10 parts, chrysanthemum 8 parts, and eucommia leaf 11 parts.

[0008] Preferably, the mass ratio of Gastrodia elata and earthworm protein is 1.2 to 3.6:1, the mass ratio of Polygonatum sibiricum, Dioscorea opposita, and Pueraria lobata is 4:3:3 to 5:4:3.5, and the mass ratio of Crataegus pinnatifida, Morus alba, Melon japonica, Cassia tora, and Chrysanthemum morifolium is 8:7:6:7:5 to 14:13:12:14:11.

[0009] In one or more embodiments of the present invention, a method for preparing a medicinal and edible homologous tablet composition that soothes the liver, unblocks the meridians, and improves blood rheology includes the following steps: Step 1: Raw material sorting and cleaning: Select herbal raw materials that are free from mold, impurities, and insects, rinse them with purified water and drain them; select food-grade purified earthworm protein for later use. Step 2, Ultrafine Low-Temperature Grinding: The cleaned Gastrodia elata, Polygonatum sibiricum, Dioscorea opposita, Pueraria lobata, Cassia tora, and Eucommia ulmoides leaves are pre-frozen at -10℃ to 0℃, and then ground to 200 to 500 mesh using an ultrafine pulverizer to obtain ultrafine herbal powder for later use. Step 3: Low-temperature dynamic circulation extraction: Place the Gastrodia elata, Polygonatum sibiricum, Pueraria lobata, Cassia tora, and Eucommia ulmoides leaves from the ultrafine herbal powder obtained in Step 2 into a low-temperature extraction tank, add 45℃ low-temperature ethanol, and perform dynamic circulation extraction 2-3 times at a stirring rate of 60-120 r / min, each time for 1.5-2.5 hours. Filter and combine the filtrates. Extract the hawthorn, mulberry leaves, bitter melon, and chrysanthemum with pure water at room temperature using ultrasonic extraction, filter, and collect the extraction filtrate. Step 4: Vacuum Concentration under Negative Pressure: Combine all the extracts obtained in Step 3 and concentrate them under low temperature and negative pressure at 50℃ to obtain a thick extract with a relative density of 1.25 to 1.30. Step 5, Mixing and Granulation: Mix the thick extract obtained in Step 4 with xylitol and the ultrafine herbal powder obtained in Step 2 until homogeneous, and then granulate using a wet granulation method; Step 6: Low-temperature fluidized bed drying: Place the wet granules obtained in Step 5 into a 40℃ low-temperature fluidized bed for drying until the moisture content of the material is ≤5%; Step 7: Granulation, Mixing, Tableting, Sterilization, and Packaging: The dried granules obtained in Step 6 are granulated and mixed evenly, then compressed into tablets weighing 0.6g each using a tablet press. After sterilization and packaging, the finished product is obtained.

[0010] The principles of traditional Chinese medicine formula composition: (The text abruptly ends here, likely due to an incomplete sentence or a formatting The principal ingredient, Gastrodia elata, can calm the liver and subdue yang, extinguish wind and stop dizziness; earthworm protein contains active polypeptides that can dredge the meridians and improve blood flow, playing a major therapeutic role in addressing dizziness and poor blood flow caused by hyperactivity of liver yang.

[0011] The auxiliary herbs: Polygonatum and Dioscorea opposita can invigorate the spleen and kidneys, nourish yin and consolidate the foundation, and improve blood pressure fluctuations caused by liver and kidney yin deficiency; Pueraria lobata can clear the turbidity and improve the condition of peripheral microvessels, laying the foundation for overall conditioning.

[0012] The adjuvant ingredients are: hawthorn, which can clear away turbidity and lower lipids; mulberry leaves and bitter melon, which can clear away dryness and heat; cassia seeds and chrysanthemum, which can clear liver fire. The combination of these ingredients reduces lipid accumulation and optimizes blood condition.

[0013] The medicinal ingredient, Cyclocarya paliurus leaf, harmonizes the properties of the entire formula, guides the functional components to act on the human circulatory system, reduces the irritation caused by long-term consumption, and ensures the product's mildness.

[0014] Compared with the prior art, the beneficial effects of the present invention are: (1) This invention follows the principle of traditional Chinese medicine in the combination of principal, assistant, adjuvant and guide herbs. It uses Gastrodia elata and earthworm protein as principal herbs to calm the liver and subdue yang, and to clear the meridians. It uses Polygonatum sibiricum, Dioscorea opposita and Pueraria lobata as assistant herbs to strengthen the spleen and kidneys, and to promote the upward movement of clear qi and downward movement of turbid qi. It is supplemented with hawthorn, mulberry leaf, bitter melon, cassia seed and chrysanthemum to clear turbidity, lower lipids, clear the liver and purge fire. It uses Eucommia ulmoides leaf to harmonize the whole formula and guide the medicinal properties. All the ingredients in the whole formula work together. It is effective for people with liver yang hyperactivity. After three groups of test cases, the subjects took it continuously for 90 days. The proportion of dizziness, headache and other discomfort improved by 65% ​​to 78%. The triglyceride index decreased significantly and the systolic blood pressure dropped by 2 to 9 mmHg. The effect showed a positive gradient with the optimization of the formula ratio. It can effectively relieve the sub-health state of people with borderline high blood pressure.

[0015] (2) This invention uses ultra-fine low-temperature pulverization of raw materials at -10℃ to 0℃ to avoid mechanical heat generation damaging heat-sensitive components; then, it uses dynamic circulation extraction of ethanol at 45℃ and mass transfer is enhanced by stirring at 60 to 120 r / min, which increases the extraction rate by more than 30% compared with traditional static extraction; then, it is concentrated under negative pressure at 50℃ and dried in a fluidized bed at 40℃, with the temperature controlled below 50℃ throughout the process, which maximizes the protection of the natural active structure of functional substances such as gastrodin, earthworm active polypeptide, total flavonoids, and polysaccharides; and solves the technical problems of easy inactivation and low bioavailability of existing product components.

[0016] (3) All raw materials of this invention are included in the National Health Commission’s “List of Food and Medicine Homologous Items”, which are dual-use food and medicine resources. No chemical antihypertensive drugs, hormones, preservatives or other Western medicine ingredients are added, thus eliminating food safety hazards caused by illegal additions. Attached Figure Description

[0017] Figure 1This is a schematic diagram of the production process of the composition of the present invention. Detailed Implementation

[0018] The specific embodiments of the present invention will now be described in detail with reference to the accompanying drawings, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments.

[0019] To keep the drawings concise, each drawing only schematically shows the parts relevant to the invention; these do not represent the actual structure of the product. Furthermore, for ease of understanding, in some drawings, only one of components with the same structure or function is schematically shown, or only one is labeled. In this document, "one" not only means "only one," but can also mean "more than one," and "several" includes "two" and "more than two."

[0020] In this document, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0021] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature being directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature being directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0022] In the description of this embodiment, terms such as "upper," "lower," "left," and "right" are based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of description and simplification of operation, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention.

[0023] Furthermore, in the description of this application, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance. Example

[0024] Raw material weighing (unit: kg): xylitol 12kg, gastrodia elata 15kg, earthworm protein 8kg, polygonatum 16kg, yam 13kg, kudzu root 12kg, hawthorn 11kg, mulberry leaf 10kg, bitter melon 9kg, cassia seed 10kg, chrysanthemum 8kg, and Eucommia ulmoides leaf 11kg; Drug preparation: The product is prepared by following the low-temperature activity preservation process described in step one to step one of this invention to obtain a finished tablet weighing 0.6g. Trial observation: Sixty subjects with systolic blood pressure between 135 and 145 mmHg were randomly divided into a control group (30 people) and an experimental group (30 people). The control group maintained their original daily diet, while the experimental group took 2 tablets of this product daily for 90 consecutive days. Observation results: The average systolic blood pressure of the subjects in the experimental group decreased by 3-8 mmHg, the triglyceride index decreased, and the proportion of discomfort such as dizziness and headache improved in 72% of the subjects. No abnormalities such as abdominal pain or rash occurred throughout the trial. Example

[0025] Raw material weighing (unit: kg): xylitol 10kg, gastrodia elata 12kg, earthworm protein 6kg, polygonatum 13kg, yam 10kg, kudzu root 10kg, hawthorn 9kg, mulberry leaf 8kg, bitter melon 7kg, cassia seed 8kg, chrysanthemum 6kg, and eucommia leaf 9kg; Drug preparation: The product is prepared by following the low-temperature activity preservation process described in steps one to seven of this invention to obtain a finished tablet weighing 0.6g. Trial observation: Sixty subjects with systolic blood pressure between 135 and 145 mmHg were randomly divided into a control group (30 people) and an experimental group (30 people). The control group maintained their original daily diet, while the experimental group took 2 tablets of this product daily for 90 consecutive days. Observation results: The average systolic blood pressure of the subjects in the experimental group decreased by 2-6 mmHg, the triglyceride index improved, and discomfort such as dizziness, headache, and heaviness in the body was relieved, with an overall improvement rate of over 65%; no nausea, abdominal pain, rash, or allergies occurred during the trial, indicating that the product is mild and safe to consume. Example

[0026] Raw material weighing (unit: kg): xylitol 14kg, gastrodia elata 18kg, earthworm protein 10kg, polygonatum 19kg, yam 16kg, kudzu root 14kg, hawthorn 13kg, mulberry leaf 12kg, bitter melon 11kg, cassia seed 12kg, chrysanthemum 10kg, and eucommia leaf 13kg; Drug preparation: The product is prepared by following the low-temperature activity preservation process described in steps one to seven of this invention to obtain a finished tablet weighing 0.6g. Trial observation: Sixty subjects with systolic blood pressure between 135 and 145 mmHg were randomly divided into a control group (30 people) and an experimental group (30 people). The control group maintained their original daily diet, while the experimental group took 2 tablets of this product daily for 90 consecutive days. Observation results: The average systolic blood pressure of the subjects in the experimental group decreased by 4-9 mmHg, the microcirculation of the human body was improved, the triglyceride level decreased significantly, and the proportion of discomfort such as dizziness, headache, and limb heaviness improved by 78%; the subjects tolerated the food well throughout the trial and no abnormal reactions occurred.

[0027] Based on the experimental results of three groups of different formulations in Examples 1, 2, and 3, it can be seen that within the weight range of raw materials defined by the present invention, the lower limit, preferred, and upper limit formulations can all stably achieve the effects of improving human microcirculation, assisting in regulating blood pressure, relieving physical discomfort, and optimizing metabolic indicators. The effects of the three groups of experiments are stable, and no raw material antagonism, effect failure, or adverse reactions have been observed. This proves that the formulation range of the present invention is reasonable, the product has strong stability and high practicality, and it is suitable for industrial production and long-term consumption.

[0028] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0029] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology, characterized in that, It is composed of the following raw materials in parts by weight: xylitol 8-15 parts, gastrodia elata 10-18 parts, earthworm protein 5-12 parts, polygonatum 12-20 parts, yam 10-16 parts, kudzu root 9-15 parts, hawthorn 8-14 parts, mulberry leaf 7-13 parts, bitter melon 6-12 parts, cassia seed 7-14 parts, chrysanthemum 5-11 parts, and eucommia leaf 8-15 parts.

2. The medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 1, characterized in that, The weight ratio of each ingredient is as follows: xylitol 12 parts, gastrodia elata 15 parts, earthworm protein 8 parts, polygonatum 16 parts, yam 13 parts, kudzu root 12 parts, hawthorn 11 parts, mulberry leaf 10 parts, bitter melon 9 parts, cassia seed 10 parts, chrysanthemum 8 parts, and eucommia leaf 11 parts.

3. The medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 2, characterized in that, The mass ratio of Gastrodia elata and earthworm protein is 1.2 to 3.6:1, the mass ratio of Polygonatum sibiricum, Dioscorea opposita, and Pueraria lobata is 4:3:3 to 5:4:3.5, and the mass ratio of Crataegus pinnatifida, Morus alba, Melon japonica, Cassia tora, and Chrysanthemum morifolium is 8:7:6:7:5 to 14:13:12:14:

11.

4. The medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 3, characterized in that, The gastrodia elata and earthworm protein are the principal components, the polygonatum, yam and kudzu are the assistant components, the hawthorn, mulberry leaf, bitter melon, cassia seed and chrysanthemum are the adjuvant components, and the Eucommia ulmoides leaf is the guiding component.

5. The method for preparing a medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 4, characterized in that, Includes the following steps: Step 1: Raw material sorting and cleaning: Select herbal raw materials that are free from mold, impurities, and insects, rinse them with purified water and drain them; select food-grade purified earthworm protein for later use. Step 2, Ultrafine Low-Temperature Grinding: The cleaned Gastrodia elata, Polygonatum sibiricum, Dioscorea opposita, Pueraria lobata, Cassia tora, and Eucommia ulmoides leaves are pre-frozen at -10℃ to 0℃, and then ground to 200 to 500 mesh using an ultrafine pulverizer to obtain ultrafine herbal powder for later use. Step 3: Low-temperature dynamic circulation extraction: Place the Gastrodia elata, Polygonatum sibiricum, Pueraria lobata, Cassia tora, and Eucommia ulmoides leaves from the ultrafine herbal powder obtained in Step 2 into a low-temperature extraction tank, add 45℃ low-temperature ethanol, and perform dynamic circulation extraction 2-3 times at a stirring rate of 60-120 r / min, each time for 1.5-2.5 hours. Filter and combine the filtrates. Extract the hawthorn, mulberry leaves, bitter melon, and chrysanthemum with pure water at room temperature using ultrasonic extraction, filter, and collect the extraction filtrate. Step 4: Vacuum Concentration under Negative Pressure: Combine all the extracts obtained in Step 3 and concentrate them under low temperature and negative pressure at 50℃ to obtain a thick extract with a relative density of 1.25 to 1.

30. Step 5, Mixing and Granulation: Mix the thick extract obtained in Step 4 with xylitol and the ultrafine herbal powder obtained in Step 2 until homogeneous, and then granulate using a wet granulation method; Step 6: Low-temperature fluidized bed drying: Place the wet granules obtained in Step 5 into a 40℃ low-temperature fluidized bed for drying until the moisture content of the material is ≤5%; Step 7: Granulation, Mixing, Tableting, Sterilization, and Packaging: The dried granules obtained in Step 6 are granulated and mixed evenly, then compressed into tablets weighing 0.6g each using a tablet press. After sterilization and packaging, the finished product is obtained.

6. The medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 5, and its preparation method, characterized in that, In step three, the volume fraction of the low-temperature ethanol is 50%–80%, the stirring rate of the dynamic circulation extraction is 80–100 r / min, and the extraction time is 2 hours each time.

7. The medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 6, and its preparation method, characterized in that, The pre-freezing temperature for ultra-fine low-temperature pulverization in step two is -5℃ to -2℃, and the pulverization fineness is 300 to 400 mesh.

8. The medicinal and edible homologous tablet composition for calming the liver, promoting blood circulation, and improving blood rheology according to claim 7, and its preparation method, characterized in that, The temperature of the low-temperature fluidized bed drying in step six is ​​40°C, and the moisture content of the material after drying is 3% to 5%.

9. The medicinal and edible homologous tablet composition for calming the liver, clearing the meridians, and improving blood rheology according to claim 8, and its preparation method, characterized in that, The sterilization process described in step seven uses ultraviolet sterilization, and the packaging uses individual aluminum-plastic packaging.

10. The use of the medicinal and edible homologous tableting composition according to claim 1 in the preparation of functional dietary foods that improve human microcirculation, assist in regulating blood rheological parameters, and alleviate sub-health symptoms such as dizziness and headache caused by blood pressure fluctuations.

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