Non-invasive neuromodulation system and method based on acousto-optic stimulation

Abstract

The application provides a non-invasive nerve regulation system and method based on acousto-optic-electric stimulation, and relates to the technical field of nerve regulation.The non-invasive nerve regulation system based on acousto-optic-electric stimulation comprises a control unit, which is used for controlling the output mode and output parameters of an acousto-optic-electric stimulation unit and performing safety control on the acousto-optic-electric stimulation unit, wherein the output mode comprises independent operation and joint operation based on a pre-generated time rhythm; and the acousto-optic-electric stimulation unit is used for applying non-invasive acousto-optic-electric stimulation to a subject according to the output mode and the output parameters, and comprises an electric stimulation subunit, an acoustic stimulation subunit and a light stimulation subunit.According to the technical scheme of the embodiment of the application, the output mode and output parameters of the acousto-optic-electric stimulation unit are controlled by the control unit, so that the acousto-optic-electric stimulation unit can independently or jointly operate based on the time rhythm according to the requirements, and the efficiency and effect of nerve regulation are improved.

Description

Technical Field

[0001] This invention relates to the field of neuromodulation technology, specifically to a non-invasive neuromodulation system and method based on acoustic, optical, and photoelectric stimulation. Background Technology

[0002] Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are two common non-invasive brain stimulation methods that apply direct current or alternating current of a specific frequency to brain tissue by placing electrodes on the scalp. In tDCS, anodic stimulation shifts the neuronal membrane potential towards depolarization, thereby increasing cortical excitability; cathodic stimulation shifts the membrane potential towards hyperpolarization, reducing the probability of neuronal firing and inhibiting cortical excitability. In contrast, tACS, by applying periodically varying alternating current, regulates the rhythmic changes in neuronal membrane potential without directly altering average excitability, thereby synchronizing or modulating the oscillatory activity of brain networks. Both methods can achieve neuromodulation by regulating the activity state of cortical neural networks.

[0003] The lymphocytic cerebrospinal fluid (CSF) system is a unique clearance mechanism in the brain, primarily responsible for removing waste products generated during brain metabolism. This system facilitates the removal of metabolic waste through the exchange between CSF and ISF. Research has shown that 40Hz multisensory stimulation (i.e., combined photoacoustic stimulation) can promote subtle changes in intracranial pressure, thereby accelerating the flow of CSF around brain tissue and enhancing its exchange with the interstitial fluid. This enhanced fluid exchange helps to more efficiently remove metabolic waste products from the brain, including amyloid-beta protein.

[0004] Electrical stimulation has been extensively studied in the fields of neuromodulation and cognitive improvement, but it suffers from limitations such as single stimulation target, wide current diffusion range, and significant individual variability in effects, making it difficult to achieve precise modulation of deep brain regions. Furthermore, while simple light or sound stimulation can induce changes in brain activity rhythms, its impact on cerebrospinal fluid dynamics is limited, making it difficult to significantly promote the clearance of metabolic waste products from the brain. Currently, there is an urgent need for a comprehensive, non-invasive stimulation method that can synergistically regulate neural electrical activity and the lymphocytic-cerebrospinal fluid system. Summary of the Invention

[0005] This invention provides a non-invasive neuromodulation system and method based on acoustic, optical, and photoelectric stimulation to overcome the shortcomings of low modulation accuracy in existing technologies and achieve highly accurate neuromodulation. This invention provides a non-invasive neuromodulation system based on acoustic-optical-electric stimulation, comprising: A control unit is used to control the output mode and output parameters of the acoustic-optical-electric stimulation unit and to perform safety control on the acoustic-optical-electric stimulation unit, wherein the output mode includes independent operation and joint operation based on a pre-generated time rhythm; An acoustic-optical-electric stimulation unit is used to apply non-invasive acoustic-optical-electric stimulation to a subject according to the output mode and the output parameters. It includes an electrical stimulation subunit, an acoustic stimulation subunit, and an optical stimulation subunit, which operate independently or in combination according to the output mode and the output parameters.

[0006] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the control unit includes: The control module is used to control the acoustic-optical-electric stimulation unit to operate according to the output mode based on the time rhythm, and to control the output parameters of the acoustic-optical-electric stimulation unit according to the interface input and / or preset requirements. A current module is used to provide electrical energy output to the acoustic-optical-electric stimulation unit; The interactive interface module is used to receive input output modes and output parameters, as well as to visualize the intensity information of the stimulation output of the acoustic-optical-electric stimulation unit and the operating status information of the system. The safety control module is used to control the stimulation output of the acoustic-optical-electric stimulation unit within a preset safety range, and to interrupt the stimulation output of the acoustic-optical-electric stimulation unit and / or trigger an alarm program when abnormal or unsafe information is detected.

[0007] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the stimulation output of the electrical stimulation subunit is a constant current or alternating current, which is used to perform electrical stimulation on the subject. The electrical stimulation subunit includes: The constant current output module is used to generate a preset amount of constant current or alternating current. An electrode assembly module includes electrode pads and connecting wires, wherein the electrode pads and the connecting wires are movably connected, and the electrode pads are placed at a preset position on the subject to apply the constant current or alternating current to the subject. The impedance detection module is used to detect the contact impedance between the subject's skin and the electrode pads in real time. When the contact impedance exceeds the impedance safety threshold, an abnormal message is generated and sent to the control unit.

[0008] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the electrode sheet is made of flexible conductive material and includes at least one anode and one cathode.

[0009] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the stimulation output of the acoustic stimulation subunit is a rhythmic sound wave, which is used to stimulate the subject with sound. The acoustic stimulation subunit includes: The sound signal generation module is used to generate a sound stimulation signal of a first preset frequency; A power amplifier module is used to amplify the acoustic stimulus signal to obtain rhythmic sound waves; A sound-generating component module for applying the rhythmic sound waves to the subject; The sound intensity monitoring module is used to detect the sound intensity of the rhythmic sound wave in real time, and when the sound intensity exceeds the sound intensity safety threshold, it generates unsafe information and sends it to the control unit.

[0010] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the sound-generating component module includes closed-back headphones.

[0011] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the stimulation output of the optical stimulation subunit is a rhythmic flash of light, which is used to provide optical stimulation to the subject; The photostimulation subunit includes: A light signal generating module is used to generate a flash signal of a second preset frequency as the rhythmic flash; A light source component module for applying the rhythmic flashes to the subject; The drive control module is used to adjust the stable output of light intensity and flicker rhythm; The light intensity monitoring module is used to detect the light intensity and / or flicker frequency of the rhythmic flash in real time. When the light intensity and / or flicker frequency exceed the light intensity safety threshold and / or flicker frequency safety threshold, it generates unsafe information and sends it to the control unit.

[0012] According to the present invention, a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is provided, wherein the light source component module includes an LED array.

[0013] This invention also provides a non-invasive neuromodulation method based on acoustic-optical-electric stimulation, comprising: Based on the control unit, the output mode and output parameters of the acoustic-optical-electric stimulation unit are controlled, and the acoustic-optical-electric stimulation unit is safely controlled. The output mode includes independent operation and joint operation based on a pre-generated time rhythm. According to the output mode and the output parameters, non-invasive acoustic-optical-electric stimulation is applied to the subject based on the acoustic-optical-electric stimulation unit, wherein the acoustic-optical-electric stimulation includes electrical stimulation applied based on the electrical stimulation subunit, acoustic stimulation applied based on the acoustic stimulation subunit, and / or optical stimulation applied based on the optical stimulation subunit.

[0014] The present invention also provides an electronic device, including a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein the processor executes the program to implement the non-invasive neuromodulation method based on acoustic-optical-electric stimulation as described above.

[0015] The present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the non-invasive neuromodulation method based on acoustic-optical-electric stimulation as described above.

[0016] The present invention also provides a computer program product, including a computer program that, when executed by a processor, implements the non-invasive neuromodulation method based on acoustic-optical-electric stimulation as described above.

[0017] This invention provides a non-invasive neuromodulation system and method based on acoustic-optical-electric stimulation. A control unit regulates the output mode and parameters of the acoustic-optical-electric stimulation unit, allowing the unit to operate independently or in conjunction based on a time rhythm, achieving time synchronization and parameter coordination. This ensures stable, safe, and repeatable multimodal neuromodulation. The output mode and parameters can be switched as needed, meeting individualized and multi-scenario neuromodulation applications. Safety control by the control unit ensures the safety of both the acoustic-optical-electric stimulation unit and the subject during stimulation application. The acoustic-optical-electric stimulation unit, under the control of the control unit, applies non-invasive acoustic-optical-electric stimulation to the subject, solving the problem of precise modulation of deep brain regions in existing technologies and improving the efficiency and effectiveness of neuromodulation. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the framework structure of the non-invasive neuromodulation system based on acoustic-optical-electric stimulation provided by the present invention; Figure 2 This is a schematic diagram of the host structure of the non-invasive neuromodulation system based on acoustic-optical-electric stimulation provided by the present invention; Figure 3 This is a schematic diagram of the control architecture of the non-invasive neuromodulation system based on acoustic-optical-electric stimulation provided by the present invention; Figure 4 This is a flowchart illustrating the non-invasive neuromodulation method based on acoustic-optical-electric stimulation provided by the present invention. Figure 5 This is a schematic diagram of the structure of the electronic device provided by the present invention.

[0020] Figure label: 110: Control unit; 120: Acoustic-optical-electric stimulation unit; 121: Electrical stimulation subunit; 122: Acoustic stimulation subunit; 123: Optical stimulation subunit. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0022] Based on the response of the lymphocytic cerebrospinal fluid system to multisensory stimulation (i.e., combined photoacoustic stimulation), and the improving effects of tDCS or tACS on nervous system function, cognition, and behavior, it can be inferred that the combined intervention of tDCS or tACS with 40Hz photoacoustic stimulation can significantly promote the clearance of brain metabolites by regulating neural electrical activity and cerebrospinal fluid circulation.

[0023] The following is combined Figures 1-3 The present invention describes a non-invasive neuromodulation system based on acoustic, optical, and electrical stimulation. Figure 1 This is one of the structural schematic diagrams of the non-invasive neuromodulation system based on acoustic-optical-electric stimulation provided by the present invention. Figure 1 As shown, the method includes: a control unit 110 and an acoustic-optical-electric stimulation unit 120.

[0024] The control unit 110 is used to control the output mode and output parameters of the acoustic-optical-electric stimulation unit 120 and to perform safety control on the acoustic-optical-electric stimulation unit 120. The output mode includes independent operation and joint operation based on a pre-generated time rhythm.

[0025] The control unit 110 simultaneously manages the output modes and output parameters of the acoustic-optical-electric stimulation unit 120. The output modes include the activation and deactivation of the acoustic-optical-electric stimulation unit 120, as well as the manner and characteristics of emitting stimulation signals (i.e., stimulation modes). The output parameters include the frequency and intensity of the stimulation signals, etc.

[0026] The acoustic, optical, and electrical stimulation unit 120 emits stimuli according to a time rhythm, supporting the simultaneous application of multiple modal stimuli and allowing for the setting of a sequence or alternating patterns. When multiple modal stimuli are applied simultaneously, the stimuli are executed according to the same clock according to the time rhythm, thereby outputting at the same time point or maintaining a fixed phase relationship.

[0027] It should be emphasized that the acoustic-optical-electric stimulation unit 120 supports multiple modal stimulation methods and their combinations. For example, acoustic, optical, and electric stimulation can be applied simultaneously, or any one or two of the three stimuli can be used. The settings can be configured according to the actual situation, and this application does not impose any restrictions on this.

[0028] The time rhythm can be preset or generated by the control unit 110 as needed.

[0029] Safety control is achieved through safety protection and real-time monitoring of the acoustic, optical, and electrical stimulation unit 120, ensuring the safety and accuracy of each stimulation unit during the stimulation process.

[0030] The acoustic-optical-electric stimulation unit 120 is used to apply non-invasive acoustic-optical-electric stimulation to the subject according to the output mode and the output parameters, and includes an electrical stimulation subunit 121, an acoustic stimulation subunit 122, and a light stimulation subunit 123. The electrical stimulation subunit 121, the acoustic stimulation subunit 122, and the light stimulation subunit 123 operate independently or in combination according to the output mode and the output parameters.

[0031] Each module of the electrical stimulation subunit 121, acoustic stimulation subunit 122, and optical stimulation subunit 123 operates independently or in combination according to the output mode, and achieves stimulation synchronization through a unified clock signal, thereby applying non-invasive acoustic, optical, and electrical stimulation to the subject, thus ensuring the stability, safety, and repeatability of multimodal neuromodulation.

[0032] Each module parameter (current intensity, light intensity, sound intensity, frequency, duration, etc.) can be set independently and adjusted automatically. It supports enabling any one or two stimuli separately, and the order or alternation mode can be set according to treatment needs. It can be flexibly switched from synchronous to sequential, thereby meeting the needs of individualized and multi-scenario neuromodulation applications.

[0033] tDCS affects brain function through mechanisms such as altering cortical excitability, regulating local cerebral blood flow, and increasing synaptic plasticity. Multisensory stimulation (such as sound and light stimulation) induces brain rhythm resonance and promotes cerebrospinal fluid flow, achieving synergistic regulation of neural electrical activity, brain rhythm, and lymphocytic cerebrospinal fluid clearance mechanisms, which can improve cognitive abilities such as memory and slow disease progression. tACS modulates the periodic changes in the membrane potential of cortical neurons by applying low-intensity alternating current of a specific frequency to the scalp, thereby synchronizing or reshaping the neural oscillatory activity of brain networks. This technique can enhance or restore abnormal brain rhythms (such as gamma rhythms), improve neural network connectivity and synaptic plasticity, and thus promote the recovery of cognitive function.

[0034] This invention overcomes the limitations of existing single-modal stimulation mechanisms by integrating multimodal physical stimulation methods such as electrical, acoustic, and optical stimulation. It regulates neural electrical activity and cortical excitability, induces brain rhythm resonance, and promotes cerebrospinal fluid flow, thereby synergistically improving neural function. This invention can also be used to reveal the interaction and synergistic mechanisms of different stimulation methods acting on multiple neurophysiological pathways, providing new theoretical basis for understanding brain function regulation networks and constructing a comprehensive neuroregulatory model with multi-mechanism interactions.

[0035] This invention provides a non-invasive neuromodulation system and method based on acoustic-optical-electric stimulation. A control unit regulates the output mode and parameters of the acoustic-optical-electric stimulation unit, allowing the unit to operate independently or in conjunction based on a time rhythm, achieving time synchronization and parameter coordination. This ensures stable, safe, and repeatable multimodal neuromodulation. The output mode and parameters can be switched as needed, meeting individualized and multi-scenario neuromodulation applications. Safety control by the control unit ensures the safety of both the acoustic-optical-electric stimulation unit and the subject during stimulation application. The acoustic-optical-electric stimulation unit, under the control of the control unit, applies non-invasive acoustic-optical-electric stimulation to the subject, solving the problem of precise modulation of deep brain regions in existing technologies and improving the efficiency and effectiveness of neuromodulation.

[0036] The control unit 110 is further described below. In some embodiments, the control unit 110 includes: The control module is used to control the acoustic-optical-electric stimulation unit to operate according to the output mode based on the time rhythm, and to control the output parameters of the acoustic-optical-electric stimulation unit according to interface input and / or preset requirements.

[0037] The control module is used to individually or in combination (according to a time rhythm) turn the three stimulation subunits on and off, causing them to operate according to the output mode. It is also used to control the output parameters of the acoustic-optical-electric stimulation unit, which can be determined based on interface input or preset requirements.

[0038] According to the example embodiment, the output parameters include parameters such as the intensity, duration and stimulation mode of the current set by the electrical stimulation subunit 121; the photostimulation subunit 123 controls the spectral color, stimulation duration and interval period and the sound stimulation subunit 122 adjusts the sound intensity and stimulation duration.

[0039] A current module is used to provide electrical energy output to the acoustic-optical-electric stimulation unit.

[0040] The power supply structure of the current module can be selected according to the situation, and the present invention does not impose any restrictions on it.

[0041] According to the example embodiment, the current module adopts a plug-in external power supply structure and is equipped with an AC-DC conversion module to convert mains power into a stable low-voltage DC power supply, and outputs a stable DC power or a modulated AC signal as needed by the system. The current module provides independent and stable power output to the electrical stimulation subunit 121, the acoustic stimulation subunit 122, and the light stimulation subunit 123 through internal power distribution and voltage regulation circuitry to support the operation of DC or AC stimulation modes.

[0042] The output of the electrical stimulation subunit 121 is equipped with a constant current control and overcurrent protection circuit to ensure the accuracy and safety of the stimulation current; the power supply terminals of the photoacoustic stimulation subunit 122 and the photostimulation subunit 123 are equipped with voltage regulation and filtering circuits to avoid interference from current fluctuations on the light intensity and sound intensity output.

[0043] Furthermore, to facilitate use in various application scenarios, in some embodiments, the current module supports dual power supply modes, allowing it to operate directly when plugged in, or to be connected to an external backup battery to ensure portability and continuous operation.

[0044] The interactive interface module is used to receive input output modes and output parameters, as well as to visualize the intensity information of the stimulation output of the acoustic-optical-electric stimulation unit and the operating status information of the system.

[0045] The interactive interface module enables the system to perform human-computer interaction. Operators can input and set the output modes and parameters of the electrical stimulation subunit 121, acoustic stimulation subunit 122, and light stimulation subunit 123 through a computer terminal, including stimulation mode, intensity, frequency, duration, and synchronization method.

[0046] The interactive interface module can also display in real time the intensity information of the stimulation output of the acoustic-optical-electric stimulation unit 120 (such as current, voltage, light intensity, sound intensity, etc.) and the system operating status (such as the normal operation of the electrical stimulation subunit 121, etc.) during the treatment process.

[0047] Furthermore, the interactive interface module also features data logging and anomaly alarm functions. It records data during system operation and displays alarms on the interactive interface based on alarm procedures triggered by the safety control module.

[0048] The safety control module is used to control the stimulation output of the acoustic-optical-electric stimulation unit within a preset safety range, and to interrupt the stimulation output of the acoustic-optical-electric stimulation unit 120 and / or trigger an alarm program when abnormal or unsafe information is detected.

[0049] The safety control module includes safety protection and real-time monitoring components respectively located in the electrical stimulation subunit 121, the acoustic stimulation subunit 122, and the light stimulation subunit 123.

[0050] The safety control module includes an automatic shutdown system, an overload protection circuit, and a skin resistance detection module. It can automatically interrupt the stimulation output when abnormal information (such as abnormal current, voltage, or abnormal contact impedance) is detected, preventing safety risks caused by overstimulation or equipment failure, thereby ensuring the safety and reliability of the treatment process.

[0051] The safety control module also features brightness and illumination duration limit control functions to prevent visual fatigue or retinal irritation caused by excessive light intensity or prolonged flickering; its spectral output undergoes safety filtering to ensure that the light wavelength range meets human safety standards. Additionally, it detects sound intensity in real time and automatically limits it within a safe range to prevent auditory overload or discomfort.

[0052] When unsafe information is detected (such as light or sound intensity exceeding a preset safety threshold), an alarm program can be automatically triggered and / or the stimulation output can be automatically interrupted, thereby further ensuring the safety and reliability of the sound, light, and electricity stimulation.

[0053] The following provides a further description of the electrical stimulation subunit 121. According to an example embodiment, the stimulation output of the electrical stimulation subunit 121 is a constant current or alternating current, used to electrically stimulate the subject.

[0054] The electrical stimulation subunit 121 can be a transcranial direct current stimulation unit or a transcranial alternating current stimulation unit, used to apply low-intensity electrical stimulation signals to the scalp surface of the subject.

[0055] According to the example embodiment, the electrical stimulation subunit 121 is a transcranial direct current stimulation unit, that is, it adopts the transcranial direct current stimulation mode. At this time, by forming a stable electric field between the anode and the cathode, the membrane potential of neurons in the target brain region is regulated, thereby changing the cortical excitability and neural network activity state. Anode stimulation can enhance local nerve excitability, while cathode stimulation can produce an inhibitory effect.

[0056] According to the example embodiment, the electrical stimulation subunit 121 is a transcranial alternating current stimulation unit, that is, it adopts the transcranial alternating current stimulation mode. At this time, by outputting an alternating current signal of a specific frequency, the neuronal membrane potential is made to change periodically, thereby regulating or synchronizing the oscillatory activity of the brain region.

[0057] It is understood that the electrical stimulation subunit 121 can work independently or in conjunction with the acoustic stimulation subunit 122 and / or the light stimulation subunit 123 to form multimodal joint stimulation.

[0058] The electrical stimulation subunit 121 includes: The constant current output module is used to generate a constant current of a preset size or an AC stimulation signal of a specific frequency.

[0059] The constant current output module is powered by the control unit 110, and the amplitude, frequency, and waveform parameters of the output current can be set as needed. According to the example embodiment, the constant current output module can output a stable current signal of 0.5–20 mA and can operate in DC or AC mode to meet the needs of different stimulation methods.

[0060] An electrode assembly module includes electrode pads and connecting wires, the electrode pads and the connecting wires being movably connected, the electrode pads being placed at a preset position on the subject to apply the constant current or alternating current stimulation signal to the subject.

[0061] The electrode pads are available in various sizes and can be replaced as needed. When smaller diameter or multi-channel electrode arrays are used, high-precision tDCS (HD-tDCS) stimulation can be achieved to meet the needs of more precise target area modulation.

[0062] Shielded wires can be used for connecting cables to reduce electromagnetic interference. The electrode plates and connecting wires are connected in a movable manner, which facilitates operation and maintenance.

[0063] According to the example embodiment, the connecting wire adopts a pluggable interface design and is connected to the electrode plate through the pluggable interface.

[0064] In some embodiments, the preset location may be determined according to the International 10–20 EEG system.

[0065] The impedance detection module is used to detect the contact impedance between the subject's skin and the electrode pads in real time. When the contact impedance exceeds the impedance safety threshold, an abnormal message is generated and sent to the control unit.

[0066] The impedance detection module monitors the skin-electrode contact status in real time. When the contact impedance exceeds the safety threshold, it generates abnormal information and automatically sends it to the control unit 110 to trigger an alarm or stop the output.

[0067] According to an example embodiment, the acoustic-optical-electric stimulation unit 120 also includes an electroencephalogram (EEG) acquisition module.

[0068] The EEG acquisition module is used to acquire the subject's EEG signals and obtain the subject's physiological state based on the EEG signals.

[0069] The EEG acquisition module can provide the electrical stimulation subunit 121, acoustic stimulation subunit 122 and light stimulation subunit 123 with the EEG signals after stimulation, and obtain the physiological state of the brain after stimulation by reading the EEG signals.

[0070] Furthermore, the physiological state of the brain can be fed back to the electrical stimulation subunit 121 to optimize the stimulation method, including the timing, location, and intensity of the stimulation.

[0071] According to the example embodiment, the EEG acquisition module uses 64 channels, and the synchronization accuracy between the EEG signal and the DC stimulation signal is within 1ms.

[0072] In some embodiments, the electrode sheet is a flexible conductive material and includes at least one anode and one cathode.

[0073] The electrode pads are made of flexible conductive material to reduce skin resistance and improve stimulation comfort. To ensure the implementation of electrical stimulation, they include at least one anode and one cathode.

[0074] Furthermore, in the specific implementation process, before placing the electrode pads, the subject needs to clean their scalp to remove oil and dirt in order to reduce the contact resistance between the electrode pads and the scalp; if the electrode pads need to be placed in an area with hair, the subject's hair should be parted as much as possible to expose more skin to ensure good contact between the electrode pads and the scalp; after the electrode pads are placed, they should be fixed with a strap or headband to ensure that the electrodes do not shift during treatment.

[0075] According to the example embodiment, the technical parameters of the electrical stimulation subunit 121 are shown in Table 1.

[0076] Table 1 Technical parameters of the electrical stimulation subunit 121

[0077] The acoustic stimulation subunit 122 will be further described below. In some embodiments, the stimulation output of the acoustic stimulation subunit is a rhythmic sound wave, used to provide acoustic stimulation to the subject.

[0078] The acoustic stimulation subunit 122 is used for non-invasive modulation of brain function through the auditory pathway. This unit is based on rhythmic sound wave stimulation at a first preset frequency, modulating brain rhythms. The acoustic stimulation subunit 122 can operate independently or in conjunction with the electrical stimulation subunit 121 and / or the optical stimulation subunit 123.

[0079] According to the example embodiment, the first preset frequency is 40Hz; in other embodiments, the preset frequency can also be set to other frequencies according to actual application requirements.

[0080] The acoustic stimulation subunit 122 includes: The sound signal generation module is used to generate a sound stimulation signal of a first preset frequency.

[0081] The sound signal generation module is powered and controlled by the control unit 110, and the frequency of the sound stimulus signal (denoted as the first preset frequency) can be set as needed. According to the example embodiment, a 40Hz sound stimulus signal is generated.

[0082] A power amplifier module is used to amplify the acoustic stimulus signal to obtain rhythmic sound waves.

[0083] The power amplifier module amplifies the acoustic stimulus signal and outputs a stable sound pressure level signal (rhythmic sound wave), with limiting and filtering functions to ensure that the sound signal is stable and distortion-free.

[0084] A sound-generating component module for applying the rhythmic sound waves to the subject.

[0085] The sound-generating component module can be selected according to the actual situation, and a comfortable wearing structure can be provided to improve the user experience.

[0086] The sound intensity monitoring module is used to detect the sound intensity of the rhythmic sound wave in real time. When the sound intensity exceeds the sound intensity safety threshold, it generates unsafe information and sends it to the control unit 110.

[0087] The sound intensity monitoring module monitors rhythmic sound waves in real time. When the sound intensity exceeds the sound intensity safety threshold, it automatically generates an unsafe information and sends it to the control unit 110 to trigger an alarm and / or automatically interrupt the stimulation output to prevent auditory discomfort or damage.

[0088] According to the example embodiment, the sound intensity safety threshold is 80 dB.

[0089] In some embodiments, the sound-generating component module includes closed-back headphones.

[0090] The sound-generating module uses closed-back headphones, whose sound generators have a comfortable wearing structure to improve the user experience for test subjects.

[0091] Furthermore, in the specific implementation process, before stimulation, an appropriate sound intensity should be selected according to the subject's hearing status, and the wearing position of the closed-back headphones should be adjusted to ensure symmetrical stimulation of both ears. A quiet environment should be maintained during stimulation to avoid external noise interference; the operator can monitor the output sound pressure and signal waveform in real time through the interactive interface module. After stimulation, the sound intensity should be automatically reduced to a safe level and the output should stop to ensure auditory adaptation and recovery.

[0092] According to the example embodiment, the technical parameters of the acoustic stimulator subunit 122 are shown in Table 2.

[0093] Table 2 Technical parameters of acoustic stimulator subunit 122

[0094] The photostimulation subunit 123 is further described below. In some embodiments, the stimulation output of the photostimulation subunit 123 is a rhythmic flash of light, used to provide photostimulation to the subject.

[0095] The light stimulation subunit 123 is used to non-invasively regulate the rhythm of brain neural activity through the visual pathway. This unit uses flashing light stimulation at a second preset frequency as its core, and promotes neural plasticity and coordination of brain function by regulating the rhythmic activity of relevant neural circuits.

[0096] The photostimulation subunit 123 can be used independently or in conjunction with the electrical stimulation subunit 121 and / or the acoustic stimulation subunit 122.

[0097] According to the example embodiment, the second preset frequency is 40Hz; in other embodiments, the preset frequency can also be set to other frequencies according to actual application requirements.

[0098] The photostimulation subunit 123 includes: The light signal generating module is used to generate a flash signal of a second preset frequency as the rhythmic flash.

[0099] The light signal generating module is powered by the control unit 110, and the frequency of the flash signal (denoted as the second preset frequency) can be set as needed. According to the example embodiment, a 40Hz flash signal is generated.

[0100] A light source component module for applying the rhythmic flashes to the subject.

[0101] The light source module can output different spectra (e.g., white, blue, or red light) to suit different experimental needs. The illumination is uniform, the flicker is stable, and the brightness is adjustable within a safe range, thus applying stable light stimulation to the subject through the generated rhythmic flashes.

[0102] The drive control module is used to adjust the stable output of light intensity and flicker rhythm.

[0103] The drive control module is used to adjust the stable output of light intensity and flicker rhythm. It has constant current drive, anti-interference and overload protection functions to ensure the accuracy and stability of light output.

[0104] The light intensity monitoring module is used to detect the light intensity and / or flicker frequency of the rhythmic flash in real time. When the light intensity and / or flicker frequency exceed the light intensity safety threshold and / or flicker frequency safety threshold, it generates unsafe information and sends it to the control unit.

[0105] The light intensity monitoring module monitors the light intensity in real time. When the light intensity and / or flicker frequency exceed the corresponding safety threshold, it automatically generates an unsafe information and sends it to the control unit 110 to automatically trigger an alarm and / or interrupt the stimulation output to prevent visual fatigue or retinal stimulation.

[0106] In some embodiments, the light source component module includes an LED array.

[0107] The light source module uses a high-brightness, low-heat LED array as the light source and has a programmable control interface, which can apply rhythmic flashes to the subject as needed.

[0108] Furthermore, in the specific implementation process, before use, output parameters such as flicker frequency, light intensity, spectral type, and stimulation duration should be set according to the experimental or treatment plan. During stimulation, the subject should maintain a comfortable sitting posture, keep a fixed distance between their eyes and the light source, and avoid looking directly at the high-intensity light spot. The operator can monitor the light intensity and flicker status in real time through the interactive interface module and adjust the parameters in a timely manner based on the subject's feedback. After stimulation, the light intensity should be automatically reduced and the light source should be turned off to avoid discomfort caused by instantaneous brightness changes.

[0109] According to the example embodiment, the technical parameters of the photostimulation subunit 123 are shown in Table 3.

[0110] Table 3 Technical parameters of photostimulation subunit 123

[0111] According to the example embodiment, the system adopts an integrated portable host structure. The shell is made of SPCC cold-rolled steel sheet with powder coating and a frosted, stain-resistant finish, combining lightweight and durability. A high-definition touch screen is set on the front of the host as an interactive interface module for parameter display and human-computer interaction; modular interfaces are provided on the top and sides for connecting electrical stimulation electrode pads, acoustic stimulation headphones, and light source component modules. The overall appearance of the device is mainly white and light gray, complemented by blue and red status indicator lights.

[0112] In one specific embodiment, the host is as follows: Figure 2 As shown.

[0113] Furthermore, the light source component module of the photostimulation subunit 123 is embedded in the wearable glasses to apply photostimulation to the user.

[0114] Based on this, an embodiment of a non-invasive neuromodulation system based on acoustic-optical-electric stimulation is given, such as... Figure 3 As shown, the control unit 110 generates a time rhythm and simultaneously manages electrical stimulation, light stimulation, and sound stimulation according to the corresponding synchronous trigger signal. It controls the electrical stimulation subunit 121, sound stimulation subunit 122, and light stimulation subunit 123 to perform transcranial current stimulation, sound stimulation, and light stimulation through output parameters. The operating data (i.e., operating status information) of the electrical stimulation subunit 121, sound stimulation subunit 122, and light stimulation subunit 123 are returned to the control unit 110 for display on the interactive interface module. The safety control module monitors the safety status of the electrical stimulation subunit 121, sound stimulation subunit 122, and light stimulation subunit 123. When abnormal / unsafe information occurs, it feeds back to the control unit 110 to automatically interrupt the stimulation output and / or trigger an alarm program. Simultaneously, the control unit 110 can also adjust based on the feedback to achieve comprehensive regulation of neural electrical activity, brain rhythm, etc., thereby improving neural function and enhancing neural plasticity.

[0115] The non-invasive neuromodulation method based on acoustic-optical-electric stimulation provided by the present invention will be described below. The non-invasive neuromodulation method based on acoustic-optical-electric stimulation described below can be referred to in correspondence with the non-invasive neuromodulation system based on acoustic-optical-electric stimulation described above. Figure 4 This is a schematic diagram of the non-invasive neuromodulation method based on acoustic-optical-electric stimulation provided by the present invention, as shown below. Figure 4 As shown, the method includes: Step 410: Based on the control unit, control the output mode and output parameters of the acoustic-optical-electric stimulation unit, and perform safety control on the acoustic-optical-electric stimulation unit, wherein the output mode includes independent operation and joint operation based on a pre-generated time rhythm.

[0116] Step 420: According to the output mode and the output parameters, apply non-invasive acoustic-optical-electric stimulation to the subject based on the acoustic-optical-electric stimulation unit, wherein the acoustic-optical-electric stimulation includes electrical stimulation applied based on the electrical stimulation subunit, acoustic stimulation applied based on the acoustic stimulation subunit, and / or light stimulation applied based on the light stimulation subunit.

[0117] The method performs similar functions to the system provided earlier. Other functions can be found in the previous descriptions and will not be repeated here.

[0118] Figure 5 An example is a schematic diagram of the physical structure of an electronic device, such as... Figure 5As shown, the electronic device may include a processor 510, a communication interface 520, a memory 530, and a communication bus 540, wherein the processor 510, the communication interface 520, and the memory 530 communicate with each other via the communication bus 540. The processor 510 can call logical instructions in the memory 530 to execute a non-invasive neuromodulation method based on acoustic-optical-electric stimulation. This method includes: controlling the output mode and output parameters of the acoustic-optical-electric stimulation unit based on a control unit, and performing safety control on the acoustic-optical-electric stimulation unit, wherein the output mode includes independent operation and combined operation based on a pre-generated time rhythm; and applying non-invasive acoustic-optical-electric stimulation to the subject based on the output mode and the output parameters, wherein the acoustic-optical-electric stimulation includes electrical stimulation applied based on an electrical stimulation subunit, acoustic stimulation applied based on an acoustic stimulation subunit, and / or optical stimulation applied based on an optical stimulation subunit.

[0119] Furthermore, the logical instructions in the aforementioned memory 530 can be implemented as software functional units and, when sold or used as independent products, can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present invention, or the part that contributes to the prior art, or a part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of the present invention. The aforementioned storage medium includes various media capable of storing program code, such as USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.

[0120] On the other hand, the present invention also provides a computer program product, which includes a computer program that can be stored on a non-transitory computer-readable storage medium. When the computer program is executed by a processor, the computer is able to execute the non-invasive neuromodulation method based on acoustic-optical-electric stimulation provided by the above methods. The method includes: controlling the output mode and output parameters of the acoustic-optical-electric stimulation unit based on a control unit, and performing safety control on the acoustic-optical-electric stimulation unit, wherein the output mode includes independent operation and joint operation based on a pre-generated time rhythm; applying non-invasive acoustic-optical-electric stimulation to the subject based on the output mode and the output parameters, wherein the acoustic-optical-electric stimulation includes electrical stimulation applied based on an electrical stimulation subunit, acoustic stimulation applied based on an acoustic stimulation subunit, and / or optical stimulation applied based on an optical stimulation subunit.

[0121] In another aspect, the present invention also provides a non-transitory computer-readable storage medium storing a computer program thereon, which, when executed by a processor, implements the non-invasive neuromodulation method based on acoustic-optical-electric stimulation provided by the methods described above. The method includes: controlling the output mode and output parameters of an acoustic-optical-electric stimulation unit based on a control unit, and performing safety control on the acoustic-optical-electric stimulation unit, wherein the output mode includes independent operation and combined operation based on a pre-generated time rhythm; and applying non-invasive acoustic-optical-electric stimulation to a subject based on the output mode and the output parameters, wherein the acoustic-optical-electric stimulation includes electrical stimulation applied based on an electrical stimulation subunit, acoustic stimulation applied based on an acoustic stimulation subunit, and / or optical stimulation applied based on an optical stimulation subunit.

[0122] The system embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the modules can be selected to achieve the purpose of this embodiment according to actual needs. Those skilled in the art can understand and implement this without any creative effort.

[0123] Through the above description of the embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus necessary general-purpose hardware platforms, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solutions, in essence or the part that contributes to the prior art, can be embodied in the form of a software product. This computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, magnetic disk, optical disk, etc., and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute the methods described in the various embodiments or some parts of the embodiments.

[0124] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A non-invasive neuromodulation system based on acoustic-optical-electric stimulation, characterized in that, include: A control unit is used to control the output mode and output parameters of the acoustic-optical-electric stimulation unit and to perform safety control on the acoustic-optical-electric stimulation unit, wherein the output mode includes independent operation and joint operation based on a pre-generated time rhythm; An acoustic-optical-electric stimulation unit is used to apply non-invasive acoustic-optical-electric stimulation to a subject according to the output mode and the output parameters. It includes an electrical stimulation subunit, an acoustic stimulation subunit, and an optical stimulation subunit, which operate independently or in combination according to the output mode and the output parameters.

2. The system according to claim 1, characterized in that, The control unit includes: The control module is used to control the acoustic-optical-electric stimulation unit to operate according to the output mode based on the time rhythm, and to control the output parameters of the acoustic-optical-electric stimulation unit according to the interface input and / or preset requirements. A current module is used to provide electrical energy output to the acoustic-optical-electric stimulation unit; The interactive interface module is used to receive input output modes and output parameters, as well as to visualize the intensity information of the stimulation output of the acoustic-optical-electric stimulation unit and the operating status information of the system. The safety control module is used to control the stimulation output of the acoustic-optical-electric stimulation unit within a preset safety range, and to interrupt the stimulation output of the acoustic-optical-electric stimulation unit and / or trigger an alarm program when abnormal or unsafe information is detected.

3. The system according to claim 1, characterized in that, The stimulation output of the electrical stimulation subunit is a constant current or alternating current, used to provide electrical stimulation to the subject. The electrical stimulation subunit includes: The constant current output module is used to generate a preset amount of constant current or alternating current. An electrode assembly module includes electrode pads and connecting wires, wherein the electrode pads and the connecting wires are movably connected, and the electrode pads are placed at a preset position on the subject to apply the constant current or alternating current to the subject. The impedance detection module is used to detect the contact impedance between the subject's skin and the electrode pads in real time. When the contact impedance exceeds the impedance safety threshold, an abnormal message is generated and sent to the control unit.

4. The system according to claim 3, characterized in that, The electrode sheet is made of a flexible conductive material and includes at least one anode and one cathode.

5. The system according to claim 1, characterized in that, The stimulation output of the acoustic stimulation subunit is a rhythmic sound wave, which is used to stimulate the subject. The acoustic stimulation subunit includes: The sound signal generation module is used to generate a sound stimulation signal of a first preset frequency; A power amplifier module is used to amplify the acoustic stimulus signal to obtain rhythmic sound waves; A sound-generating component module for applying the rhythmic sound waves to the subject; The sound intensity monitoring module is used to detect the sound intensity of the rhythmic sound wave in real time, and when the sound intensity exceeds the sound intensity safety threshold, it generates unsafe information and sends it to the control unit.

6. The system according to claim 5, characterized in that, The sound-generating component module includes closed-back headphones.

7. The system according to claim 1, characterized in that, The stimulation output of the photostimulation subunit is a rhythmic flash, used to provide photostimulation to the subject. The photostimulation subunit includes: A light signal generating module is used to generate a flash signal of a second preset frequency as the rhythmic flash; A light source component module for applying the rhythmic flashes to the subject; The drive control module is used to adjust the stable output of light intensity and flicker rhythm; The light intensity monitoring module is used to detect the light intensity and / or flicker frequency of the rhythmic flash in real time. When the light intensity and / or flicker frequency exceed the light intensity safety threshold and / or flicker frequency safety threshold, it generates unsafe information and sends it to the control unit.

8. The system according to claim 7, characterized in that, The light source component module includes an LED array.

9. A non-invasive neuromodulation method based on acoustic-optical-electric stimulation, employing the non-invasive neuromodulation system based on acoustic-optical-electric stimulation as described in any one of claims 1-8, characterized in that, include: Based on the control unit, the output mode and output parameters of the acoustic-optical-electric stimulation unit are controlled, and the acoustic-optical-electric stimulation unit is safely controlled. The output mode includes independent operation and joint operation based on a pre-generated time rhythm. According to the output mode and the output parameters, non-invasive acoustic-optical-electric stimulation is applied to the subject based on the acoustic-optical-electric stimulation unit, wherein the acoustic-optical-electric stimulation includes electrical stimulation applied based on the electrical stimulation subunit, acoustic stimulation applied based on the acoustic stimulation subunit, and / or optical stimulation applied based on the optical stimulation subunit.

10. An electronic device comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, characterized in that, When the processor executes the program, it implements the non-invasive neuromodulation method based on acoustic-optical-electric stimulation as described in any one of claims 9.

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