Radial chromatography column and method of manufacture

Abstract

This invention discloses a radial chromatography column and its processing method, comprising a column body and a support cylinder. The column body has an upper mounting plate and a lower mounting plate at its upper and lower ends, respectively, connected by a connecting rod. The support cylinder has an upper flow divider plate and a lower flow divider plate at its upper and lower ends, respectively. The upper flow divider plate is connected to the upper mounting plate via a locking member, and the lower flow divider plate is connected to the lower mounting plate via a locking member. An inner screen and an outer screen are sequentially fitted outside the support cylinder, forming a packing cavity between them. The inner screen has a first mounting assembly at its upper and lower ends, and the outer screen has a second mounting assembly at its upper and lower ends. Both the upper first and second mounting assemblies are connected to the upper flow divider plate via locking members, and both the lower first and second mounting assemblies are connected to the lower mounting plate via locking members. This invention can withstand high volumetric flow rates and high pressures, and while ensuring the sealing of the joints, it can reduce the amount and difficulty of welding, and guarantee welding quality.

Description

Technical Field

[0001] This invention relates to the field of separation and purification equipment and processing methods, and in particular to a radial chromatography column and processing method. Background Technology

[0002] Traditional chromatography columns are mostly axial, which suffer from low separation resolution, long separation time, and high back pressure during purification. To address this, radial chromatography columns have emerged. Compared to traditional columns, radial columns have a shorter flow path and larger cross-sectional area, enabling them to withstand high volumetric flow rates without generating high back pressure, making them particularly suitable for processing large-volume samples and high-viscosity fluids. Furthermore, radial chromatography columns can be scaled up linearly, maintaining a constant bed depth while increasing only the vertical height. This design ensures consistency and predictability from pilot-scale to production scale, simplifying the process development process. However, existing radial chromatography columns, such as the radial flow chromatography column disclosed in US Patent 10718744B2, use grooves at both ends for positioning the filter element. This results in low structural strength and poor stability, making the filter element prone to deformation or even damage under pressure. Therefore, it cannot withstand high volumetric flow rates and high pressures, requiring further improvement. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a radial chromatography column with good structural stability, resistance to deformation, and resistance to high volumetric flow rate and high pressure.

[0004] The present invention further provides a method for processing the above-mentioned radial chromatography column.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: A radial chromatography column includes a column body and a support cylinder disposed within the column body. An upper mounting plate and a lower mounting plate are respectively provided at the upper and lower ends of the column body, and the upper and lower mounting plates are connected by a connecting rod. An upper flow divider plate and a lower flow divider plate are respectively provided at the upper and lower ends of the support cylinder. The upper flow divider plate is connected to the upper mounting plate by a locking member, and the lower flow divider plate is connected to the lower mounting plate by a locking member. An inner screen and an outer screen are sequentially sleeved outside the support cylinder, forming a packing cavity between the inner and outer screens. A first mounting assembly is provided at the upper and lower ends of the inner screen, and a second mounting assembly is provided at the upper and lower ends of the outer screen. Both the upper and lower first and second mounting assemblies are connected to the upper flow divider plate by locking members, and both the lower and lower first and second mounting assemblies are connected to the lower mounting plate by locking members.

[0006] As a further improvement to the above technical solution: the outer edge of the first mounting component and the inner edge of the second mounting component both extend into the packing cavity; a first inner seal and a first outer seal are provided between the first mounting component and the upper diverter plate; the upper diverter plate is provided with a locking member for connecting the first mounting component between the first inner seal and the first outer seal; a second inner seal and a second outer seal are provided between the second mounting component and the upper diverter plate; the upper diverter plate is provided with a locking member for connecting the second mounting component between the second inner seal and the second outer seal.

[0007] As a further improvement to the above technical solution, it also includes a sample inlet, a sample outlet, a packing inlet, and a packing outlet. There is a gap between the column and the outer screen to form a first channel, and a gap between the inner screen and the support cylinder to form a second channel. The packing inlet and the packing outlet are both connected to the packing cavity. The sample inlet is connected to the first channel, and the sample outlet is connected to the second channel; or, the sample inlet is connected to the second channel, and the sample outlet is connected to the first channel.

[0008] As a further improvement to the above technical solution: a first flushing gap and a second flushing gap are provided between the upper diverter plate and the first mounting assembly at the upper end. The first flushing gap communicates with the second channel to clean the first inner seal, and the second flushing gap communicates with the packing cavity to clean the first outer seal. A third flushing gap and a fourth flushing gap are provided between the upper diverter plate and the second mounting assembly at the upper end. The third flushing gap communicates with the packing cavity to clean the second inner seal, and the fourth flushing gap communicates with the first channel to clean the second outer seal.

[0009] As a further improvement to the above technical solution: the edge of the upper diversion plate extends to the outer screen, and the upper diversion plate is provided with a plurality of first diversion channels along the circumference inside, and the lower diversion plate is provided with a plurality of second diversion channels along the circumference inside. One end of the first diversion channel is connected to the first channel, one end of the second diversion channel is connected to the second channel, the sample inlet is connected to the other end of the first diversion channel, and the sample outlet is connected to the other end of the second diversion channel.

[0010] As a further improvement to the above technical solution: the edge of the upper diversion plate extends to the outer screen, and the upper diversion plate is provided with a plurality of first diversion channels along the circumference inside, and the lower diversion plate is provided with a plurality of second diversion channels along the circumference inside. One end of the first diversion channel is connected to the first channel, one end of the second diversion channel is connected to the second channel, the sample inlet is connected to the other end of the second diversion channel, and the sample outlet is connected to the other end of the first diversion channel.

[0011] As a further improvement to the above technical solution: the connecting rod is provided in multiple parts, and the multiple connecting rods are distributed at intervals along the circumferential direction.

[0012] As a further improvement to the above technical solution: the lower mounting plate is provided with multiple legs, and the legs are provided with rollers.

[0013] As a further improvement to the above technical solution: both the first mounting component and the second mounting component include a solid transition piece and a mounting flange. The inner and outer sides of the inner screen and the outer screen are welded to the solid transition piece, and the outer side of the solid transition piece is welded to the mounting flange.

[0014] A method for processing a radial chromatography column as described above, wherein the processing steps for the inner and outer screens are as follows: S1. Solid transition pieces are set on two opposite sides of the sieve plate, and the two sides of the sieve plate are welded to the solid transition pieces. S2. Bend the sieve plate and solid transition piece into a cylindrical shape and weld them together. After welding, the solid transition piece is located at both ends of the sieve plate. S3. Install a mounting flange on the solid transition piece and weld the outer side of the solid transition piece to the mounting flange.

[0015] Compared with the prior art, the advantages of the present invention are as follows: The radial chromatography column disclosed in this invention has an inner screen connected to an upper distribution plate and a lower mounting plate at its upper and lower ends via a first mounting assembly, and an outer screen connected to the upper distribution plate and a lower mounting plate at its upper and lower ends via a second mounting assembly. The upper and lower mounting plates are connected by a connecting rod, which allows the inner and outer screens to be locked and fixed from both ends, thereby effectively increasing the structural strength and deformation resistance of the inner and outer screens and achieving the purpose of resisting high pressure and high volumetric flow rates.

[0016] The radial chromatography column processing method disclosed in this invention involves setting solid transition pieces on opposite sides of the sieve plate and welding both sides of the joint. Then, the outer side of the solid transition piece is welded to the mounting flange. Under the premise of ensuring the sealing of the joint, it is not limited by the inner diameter of the mounting flange, which can reduce the amount of welding work and welding difficulty, and ensure the welding quality.

[0017] Other features and advantages of the present invention will be described in detail in the following detailed description section. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the front view structure of the radial chromatography column of the present invention.

[0019] Figure 2 This is a top view of the radial chromatography column of the present invention.

[0020] Figure 3 This is a schematic diagram of the first main cross-sectional structure of the radial chromatography column of the present invention.

[0021] Figure 4 This is a schematic diagram of the second main cross-sectional structure of the radial chromatography column of the present invention.

[0022] Figure 5 This is a schematic diagram of the third main cross-sectional structure of the radial chromatography column of the present invention.

[0023] Figure 6 This is a schematic diagram of the main cross-sectional structure of the outer screen in this invention.

[0024] Figure 7 This is a schematic diagram of the main cross-sectional structure of the inner screen in this invention.

[0025] Figure 8 This is a schematic diagram of the flow path when loading samples onto the radial chromatography column according to the present invention.

[0026] Figure 9 This is an exploded view of the radial chromatography column of the present invention.

[0027] Figure 10 yes Figure 4 Enlarged view of point A in the middle.

[0028] Figure 11 This is a schematic diagram of the processing method of the radial chromatography column of the present invention.

[0029] The labels in the diagram represent: 11. Sample inlet; 12. Sample outlet; 13. Packing inlet; 14. Packing outlet; 15. Column; 16. Upper mounting plate; 17. Lower mounting plate; 18. Connecting rod; 2. Support cylinder; 3. Inner screen; 4. Outer screen; 5. First mounting assembly; 51. First inner seal; 52. First outer seal; 53. First flushing gap; 54. Second flushing gap; 55. Solid transition piece; 56. Mounting flange; 57. Sieve plate; 61. First channel; 62. Second channel; 63. Packing cavity; 7. Second mounting assembly; 71. Second inner seal; 72. Second outer seal; 73. Third flushing gap; 74. Fourth flushing gap; 81. Upper diverter plate; 82. Lower diverter plate; 83. First diverter channel; 84. Second diverter channel; 9. Support leg; 91. Roller. Detailed Implementation

[0030] In the description of this invention, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0031] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0032] In this invention, unless otherwise explicitly specified and limited, the terms "assembly," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0033] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0034] Figures 1 to 10An embodiment of the radial chromatography column of the present invention is shown. The radial chromatography column of this embodiment includes a column body 15 and a support cylinder 2 disposed within the column body 15. The upper and lower ends of the column body 15 are respectively provided with an upper mounting plate 16 and a lower mounting plate 17, which are connected by a connecting rod 18. The upper and lower ends of the support cylinder 2 are respectively provided with an upper flow divider plate 81 and a lower flow divider plate 82. The upper flow divider plate 81 is connected to the upper mounting plate 16 by a locking member, and the lower flow divider plate 82 is connected to the lower mounting plate 17 by a locking member. An inner screen 3 and an outer screen 4 are sequentially sleeved on the outside of the support cylinder 2, forming a packing cavity 63 between the inner screen 3 and the outer screen 4. The upper and lower ends of the inner screen 3 are provided with a first mounting assembly 5, and the upper and lower ends of the outer screen 4 are provided with a second mounting assembly 7. The upper first mounting assembly 5 and the upper second mounting assembly 7 are both connected to the upper flow divider plate 81 by a locking member, and the lower first mounting assembly 5 and the lower second mounting assembly 7 are both connected to the lower mounting plate 17 by a locking member. Preferably, the inner screen 3 and the outer screen 4 adopt a multi-layer structure formed by sintering, with the wire diameter gradually decreasing and the mesh diameter gradually decreasing along the flow direction of the material, thereby gradually improving the filtration accuracy; the upper end of the connecting rod 18 is threadedly connected to the upper mounting plate 16, and the lower end is fixedly connected to the lower mounting plate 17 through a locking component; the locking component can be, for example, a screw or bolt.

[0035] In this embodiment of the radial chromatography column, the inner screen 3 is connected to the upper diversion plate 81 and the lower mounting plate 17 at its upper and lower ends via the first mounting component 5, respectively. The outer screen 4 is connected to the upper diversion plate 81 and the lower mounting plate 17 at its upper and lower ends via the second mounting component 7, respectively. The upper mounting plate 16 and the lower mounting plate 17 are connected by a connecting rod 18, which can lock and fix the inner screen 3 and the outer screen 4 from the upper and lower ends, thereby effectively increasing the structural strength and deformation resistance of the inner screen 3 and the outer screen 4, achieving the purpose of resisting high pressure and high volumetric flow rate (after testing, when the pressure is 5 bar, the maximum deformation of the inner screen 3 and the outer screen 4 is only 0.032 mm; when the pressure is increased to 10 bar, the maximum deformation increases to 0.07 mm; when the pressure is further increased to 15 bar, the maximum deformation is 0.1 mm, which fully meets the usage requirements).

[0036] Specifically, such as Figure 10As shown, further, in this embodiment, the outer edge of the first mounting component 5 and the inner edge of the second mounting component 7 both extend into the packing cavity 63. In other words, the radial thickness of the first mounting component 5 and the second mounting component 7 is greater than the radial thickness of the inner screen 3 and the outer screen 4, which is beneficial to further improve the deformation resistance of the inner screen 3 and the outer screen 4, and at the same time facilitates connection with the upper diversion plate 81 and the lower mounting plate 17. A first inner seal 51 and a first outer seal 52 are provided between the first mounting component 5 and the upper diversion plate 81 (i.e., the first outer seal 52 is located on the outer periphery of the first inner seal 51). The upper diversion plate 81 is provided with a locking member for connecting the first mounting component 5 between the first inner seal 51 and the first outer seal 52. A second inner seal 71 and a second outer seal 72 are provided between the second mounting component 7 and the upper diversion plate 81 (i.e., the second outer seal 72 is located on the outer periphery of the second inner seal 71). The upper diversion plate 81 is provided with a locking member for connecting the second mounting component 7 between the second inner seal 71 and the second outer seal 72. Each sealing element can be a sealing ring or sealing strip, etc. The first inner sealing element 51 and the first outer sealing element 52 can form a two-stage seal between the first mounting assembly 5 and the upper diversion plate 81 and the lower mounting plate 17. The second inner sealing element 71 and the second outer sealing element 72 can form a two-stage seal between the second mounting assembly 7 and the upper diversion plate 81 and the lower mounting plate 17. The sealing effect is good. The locking element is located between the inner and outer two-stage seals, which helps to prevent leakage at the locking element. The structure is reasonable and effective.

[0037] Specifically, such as Figure 8 As shown, in this embodiment, the radial chromatography column further includes a sample inlet 11, a sample outlet 12, a packing inlet 13, and a packing outlet 14. A gap exists between the column body 15 and the outer sieve 4 to form a first channel 61, and a gap exists between the inner sieve 3 and the support cylinder 2 to form a second channel 62. Both the packing inlet 13 and the packing outlet 14 are connected to the packing cavity 63. The sample inlet 11 is connected to the first channel 61, and the sample outlet 12 is connected to the second channel 62. During sample loading, the sample enters the first channel 61 through the sample inlet 11, then flows radially inward through the outer sieve 4 into the packing cavity 63, interacting with the packing material. Samples that do not interact with the packing material and other materials continue to flow radially inward through the inner sieve 3, then enter the second channel 62, and finally exit through the sample outlet 12. This process is repeated until the sample passes the test. Because the sample flows radially, it possesses all the advantages of a radial chromatography column. Of course, in other embodiments, the sample inlet 11 and sample outlet 12 can be interchanged, that is, the sample inlet 11 is connected to the second channel 62, and the sample outlet 12 is connected to the first channel 61. The sample flow path during loading is... Figure 8 Instead, I will not elaborate further.

[0038] In a preferred embodiment, the sample inlet 11 and the packing inlet 13 are located on the upper mounting plate 16, and the sample outlet 12 and the packing outlet 14 are located on the lower mounting plate 17, so that the sample, packing, etc. can flow from top to bottom by gravity.

[0039] Specifically, such as Figure 10 As shown, further, in this embodiment, a first flushing gap 53 and a second flushing gap 54 are provided between the upper diverter plate 81 and the upper first mounting assembly 5. The first flushing gap 53 communicates with the second channel 62 to clean the first inner seal 51, and the second flushing gap 54 communicates with the packing cavity 63 to clean the first outer seal 52. A third flushing gap 73 and a fourth flushing gap 74 are provided between the upper diverter plate 81 and the upper second mounting assembly 7. The third flushing gap 73 communicates with the packing cavity 63 to clean the second inner seal 71, and the fourth flushing gap 74 communicates with the first channel 61 to clean the second outer seal 72. Conventional technical solutions generally require the joint formed by two mating surfaces to be as small as possible. However, this invention differs from conventional technical solutions by leaving gaps between the upper diversion plate 81 and the first mounting component 5, and between the second mounting component 7. While ensuring the sealing function of each seal, the cleaning stage can utilize cleaning media such as cleaning water in the first channel 61, the second channel 62, and the packing cavity 63 to clean the first inner seal 51, the first outer seal 52, the second inner seal 71, and the second outer seal 72, ensuring the cleanliness of each seal and avoiding cross-contamination. The sealing and cleaning structure between the lower mounting plate 17 and the lower first mounting component 5 and the second mounting component 7 can be referenced from the sealing and cleaning structure between the upper diversion plate 81 and the upper first mounting component 5 and the second mounting component 7, and will not be described again.

[0040] Specifically, such as Figure 3 and Figure 9 As shown, in this embodiment, the edge of the upper diversion plate 81 extends to the outer screen 4. Multiple first diversion channels 83 are arranged circumferentially inside the upper diversion plate 81, and multiple second diversion channels 84 are arranged circumferentially inside the lower diversion plate 82. One end of each first diversion channel 83 is connected to the first channel 61, and one end of each second diversion channel 84 is connected to the second channel 62. The sample inlet 11 is connected to the other end of the first diversion channel 83, and the sample outlet 12 is connected to the other end of the second diversion channel 84. During sample loading, after the sample enters the sample inlet 11, it is diverted through each of the first diversion channels 83 before entering the first channel 61. This improves the uniformity of sample distribution within the annular first channel 61, thereby improving the uniformity of sample distribution within the packing cavity 63. Samples and other materials that do not contribute to the flow in the second channel 62 can be collected through each of the second diversion channels 84 and enter the sample outlet 12 for centralized discharge. The structure is reasonable and effective. The number and cross-sectional area of ​​the first diversion channel 83 and the second diversion channel 84 can be determined based on actual factors such as the type of packing.

[0041] Of course, in other embodiments, the sample inlet 11 and the sample outlet 12 can be interchanged, that is, the sample inlet 11 is connected to the other end of the second diversion channel 84, and the sample outlet 12 is connected to the other end of the first diversion channel 83.

[0042] Furthermore, in this embodiment, multiple connecting rods 18 are provided, and these multiple connecting rods 18 are spaced apart along the circumferential direction. After the assembly of the internal components at both ends of the column 15 is completed, the multiple connecting rods 18 arranged in the circumferential direction can bring the upper mounting plate 16 and the lower mounting plate 17 closer together, thereby clamping the inner screen 3 and the outer screen 4 from both ends. This ensures that the inner screen 3 and the outer screen 4 are subjected to uniform force in the circumferential direction, guaranteeing their ability to withstand high pressure and high volumetric flow rate. The structure is reasonable and effective.

[0043] In a preferred embodiment, the lower mounting plate 17 is provided with a plurality of legs 9, and the legs 9 are provided with rollers 91 to facilitate the transfer of the radial chromatography column between different regions.

[0044] See details Figure 11 Furthermore, in this embodiment, both the first mounting component 5 and the second mounting component 7 include a solid transition piece 55 and a mounting flange 56. The inner and outer sides of the inner screen 3 and the outer screen 4 are welded to the solid transition piece 55, and the outer side of the solid transition piece 55 is welded to the mounting flange 56. Welding the inner and outer sides of the inner screen 3 and the outer screen 4 to the solid transition piece 55 helps to ensure the sealing of the joint. The solid transition piece 55 is only welded to the outer side of the mounting flange 56. Under the premise of ensuring the sealing of the joint, the amount of welding work and the welding difficulty can be reduced (if the inner screen 3 and the outer screen 4 are directly welded to the mounting flange 56, to ensure the sealing of the joint, both the inner and outer sides need to be welded. However, the inner diameter of the mounting flange 56 is limited. Welding in the circumferential direction on the inner side of the mounting flange 56 is difficult due to the small operating space, and the welding quality cannot be guaranteed. The solid transition piece 55 is different from the mesh structure of the inner screen 3 and the outer screen 4. It is not easily deformed, and welding the outer side to the mounting flange 56 can ensure the sealing).

[0045] See details Figure 11 The processing method of the radial chromatography column described in this embodiment, specifically the processing of the inner screen 3 and the outer screen 4, is as follows: S1. Solid transition pieces 55 (e.g., metal strips) are provided on two opposite sides of the sieve plate 57. The two sides of the sieve plate 57 (corresponding to the inner and outer sides of the inner sieve 3 and the outer sieve 4) are welded to the solid transition pieces 55. (Since the sieve plate 57 and the solid transition pieces 55 have not yet been bent into a cylindrical shape, welding can be easily completed on both sides to ensure welding quality.) S2. Bend the sieve plate 57 and the solid transition piece 55 into a cylindrical shape and weld them together. After welding, the solid transition piece 55 is located at both ends of the sieve plate 57. S3. Install a mounting flange 56 on the solid transition piece 55 and weld the outer side of the solid transition piece 55 to the mounting flange 56 (this step is done on the outer side of the mounting flange 56, so welding can be easily completed. Since both the solid transition piece 55 and the mounting flange 56 are solid parts, welding only on the outer side can ensure the sealing of the joint).

[0046] The radial chromatography column processing method of this embodiment involves setting solid transition pieces 55 on opposite sides of the sieve plate 57 and welding them on both the inner and outer sides. Then, the outer side of the solid transition piece 55 is welded to the mounting flange 56. Under the premise of ensuring the sealing of the joint, it is not limited by the inner diameter of the mounting flange 56, which can reduce the amount of welding work and welding difficulty, and ensure the welding quality.

[0047] While the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the invention. Any person skilled in the art can make many possible variations and modifications to the technical solutions of the present invention, or modify them into equivalent embodiments, without departing from the scope of the present invention. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention, without departing from the scope of the present invention, should fall within the protection scope of the present invention.

Claims

1. A radial chromatography column, characterized in that: The system includes a column (15) and a support cylinder (2) disposed within the column (15). The column (15) has an upper mounting plate (16) and a lower mounting plate (17) at its upper and lower ends, respectively. The upper mounting plate (16) and the lower mounting plate (17) are connected by a connecting rod (18). The support cylinder (2) has an upper diversion plate (81) and a lower diversion plate (82) at its upper and lower ends, respectively. The upper diversion plate (81) is connected to the upper mounting plate (16) via a locking member, and the lower diversion plate (82) is connected to the lower mounting plate (17) via a locking member. An inner screen (3) and an outer screen (4) are sequentially fitted around the cylinder (2). A filling cavity (63) is formed between the inner screen (3) and the outer screen (4). The inner screen (3) is provided with a first mounting component (5) at its upper and lower ends. The outer screen (4) is provided with a second mounting component (7) at its upper and lower ends. The first mounting component (5) and the second mounting component (7) at the upper end are both connected to the upper diversion plate (81) through locking parts. The first mounting component (5) and the second mounting component (7) at the lower end are both connected to the lower mounting plate (17) through locking parts.

2. The radial chromatography column according to claim 1, characterized in that: The outer edge of the first mounting assembly (5) and the inner edge of the second mounting assembly (7) both extend into the packing cavity (63). A first inner seal (51) and a first outer seal (52) are provided between the first mounting assembly (5) and the upper diversion plate (81). The upper diversion plate (81) is provided with a locking member for connecting the first mounting assembly (5) between the first inner seal (51) and the first outer seal (52). A second inner seal (71) and a second outer seal (72) are provided between the second mounting assembly (7) and the upper diversion plate (81). The upper diversion plate (81) is provided with a locking member for connecting the second mounting assembly (7) between the second inner seal (71) and the second outer seal (72).

3. The radial chromatography column according to claim 2, characterized in that: It also includes a sample inlet (11), a sample outlet (12), a packing inlet (13), and a packing outlet (14). There is a gap between the column (15) and the outer screen (4) to form a first channel (61). There is a gap between the inner screen (3) and the support cylinder (2) to form a second channel (62). The packing inlet (13) and the packing outlet (14) are both connected to the packing cavity (63). The sample inlet (11) is connected to the first channel (61), and the sample outlet (12) is connected to the second channel (62); or, the sample inlet (11) is connected to the second channel (62), and the sample outlet (12) is connected to the first channel (61).

4. The radial chromatography column according to claim 3, characterized in that: A first flushing gap (53) and a second flushing gap (54) are provided between the upper diverter plate (81) and the first mounting assembly (5) at the upper end. The first flushing gap (53) communicates with the second channel (62) to clean the first inner seal (51). The second flushing gap (54) communicates with the packing cavity (63) to clean the first outer seal (52). A third flushing gap (73) and a fourth flushing gap (74) are provided between the upper diverter plate (81) and the second mounting assembly (7) at the upper end. The third flushing gap (73) communicates with the packing cavity (63) to clean the second inner seal (71). The fourth flushing gap (74) communicates with the first channel (61) to clean the second outer seal (72).

5. The radial chromatography column according to claim 3, characterized in that: The upper diversion plate (81) extends to the outer screen (4) at its edge. The upper diversion plate (81) has a plurality of first diversion channels (83) arranged circumferentially inside. The lower diversion plate (82) has a plurality of second diversion channels (84) arranged circumferentially inside. One end of the first diversion channel (83) is connected to the first channel (61), and one end of the second diversion channel (84) is connected to the second channel (62). The sample inlet (11) is connected to the other end of the first diversion channel (83), and the sample outlet (12) is connected to the other end of the second diversion channel (84).

6. The radial chromatography column according to claim 3, characterized in that: The upper diversion plate (81) extends to the outer screen (4) at its edge. The upper diversion plate (81) has a plurality of first diversion channels (83) arranged circumferentially inside. The lower diversion plate (82) has a plurality of second diversion channels (84) arranged circumferentially inside. One end of the first diversion channel (83) is connected to the first channel (61), and one end of the second diversion channel (84) is connected to the second channel (62). The sample inlet (11) is connected to the other end of the second diversion channel (84), and the sample outlet (12) is connected to the other end of the first diversion channel (83).

7. The radial chromatography column according to claim 1, characterized in that: The connecting rod (18) is provided in multiple parts, and the multiple connecting rods (18) are distributed at intervals along the circumferential direction.

8. The radial chromatography column according to claim 1, characterized in that: The lower mounting plate (17) is provided with a plurality of legs (9), and the legs (9) are provided with rollers (91).

9. The radial chromatography column according to any one of claims 1 to 8, characterized in that: Both the first mounting assembly (5) and the second mounting assembly (7) include a solid transition piece (55) and a mounting flange (56). The inner and outer sides of the inner screen (3) and the outer screen (4) are welded to the solid transition piece (55), and the outer side of the solid transition piece (55) is welded to the mounting flange (56).

10. A method for processing a radial chromatography column as described in claim 9, characterized in that: The processing procedures for the inner screen (3) and the outer screen (4) are as follows: S1. Solid transition pieces (55) are provided on two opposite sides of the sieve plate (57), and the two sides of the sieve plate (57) are welded to the solid transition pieces (55). S2. Bend the sieve plate (57) and the solid transition piece (55) into a cylindrical shape and weld them together. After welding, the solid transition piece (55) is located at both ends of the sieve plate (57). S3. Install a mounting flange (56) on the solid transition piece (55) and weld the outer side of the solid transition piece (55) to the mounting flange (56).

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