A combined extrusion process of mutually insoluble systems, its use and microfluidic device

Abstract

The application belongs to the technical field of microfluidics, and discloses a combined non-miscible system process, application and microfluidic device, the process comprising: S1, mixing and homogenizing: mixing two or more than two non-miscible components and homogenizing to obtain a non-miscible mixture; S2, microfluidic shearing: taking the non-miscible mixture as an internal phase, immediately after homogenization, the non-miscible mixture is introduced into a microfluidic device, an aqueous phase and sheared oil are introduced into the microfluidic device, droplet shearing is performed, and an oil-in-water-in-oil composite droplet is formed; wherein the sheared oil contains an initiator, and the aqueous phase contains a solidified material triggered by the initiator, in the process of shearing droplets, the initiator reacts with the solidified material to solidify, and microbeads wrapping the non-miscible mixture are formed. The application uses real-time homogenization and microfluidic technology to continuously and uniformly encapsulate non-miscible components in microspheres, realizes the combination of non-miscible systems, and prepares more ornamental and innovative layered microbead products.

Description

Technical Field

[0001] This invention belongs to the field of microfluidics technology, specifically relating to a combination of characterization processes for immiscible systems, their applications, and microfluidic devices. Background Technology

[0002] Layered cosmetics are widely favored by consumers in the beauty and personal care industry due to their novel appearance and unique visual effects. These products are typically composed of two or more immiscible oil / water phase systems, which naturally separate into layers based on the density differences between the components, forming a layered appearance similar to a rainbow cocktail.

[0003] Currently, the preparation method of traditional layered cosmetics is relatively simple, mainly involving the direct mixing and filling of immiscible liquid phases. The final product is obtained by allowing the system to separate into layers based on its density difference. While this process is simple and low-cost, with market development, product homogenization is severe. The process relies mainly on simple filling and natural layering to achieve the desired appearance, resulting in highly similar formulas and forms, lacking differentiation, and failing to meet the market's demand for novel, high-end, and personalized cosmetics. Furthermore, the final layered state of the product is unstable. The liquid phase system lacks a bound structure, making it prone to layer mixing and breakage during transportation, shaking, or temperature changes. This makes it impossible to maintain a stable and uniform layered appearance over a long period, affecting product quality and user experience. Moreover, due to the immiscibility of oils, directly mixed immiscible oils are prone to rapid aggregation and separation, making it impossible to ensure the uniform distribution of each oil component in the system, resulting in significantly insufficient uniformity in product appearance and efficacy.

[0004] In summary, it is necessary to propose a process that can stably encapsulate immiscible components, achieve combined properties, and also produce a novel appearance. Summary of the Invention

[0005] To address the aforementioned technical problems, the present invention aims to provide a combined characterization process for immiscible systems, its application, and a microfluidic device. By utilizing real-time homogenization and microfluidic technology, immiscible components are continuously and uniformly encapsulated within microspheres, achieving combined characterization of immiscible components and producing more aesthetically pleasing and innovative layered microbead products.

[0006] To achieve the above-mentioned objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention proposes a combined characterization process for immiscible systems, comprising the following steps: S1. Mixing and homogenization: Mixing and homogenizing two or more immiscible components to obtain an immiscible mixture; S2, Microfluidic shearing: Using an immiscible mixture as the internal phase, it is immediately introduced into a microfluidic device after homogenization. At the same time, the aqueous phase and shearing grease are also introduced into the microfluidic device to perform droplet shearing and form an oil-in-water-in-oil composite droplet. The shearing grease contains an initiator, and the aqueous phase contains a curing material triggered by the initiator. During the shearing droplet process, the initiator in the shearing grease reacts and solidifies with the curing material in the aqueous phase, forming microbeads that encapsulate an immiscible mixture.

[0007] Preferably, two or more immiscible components are mixed and then subjected to a first homogenization process, followed by a second homogenization process after being introduced into a microfluidic device, and then sheared immediately after the second homogenization process is completed.

[0008] Preferably, the flow rate ratio of the immiscible mixture phase, the aqueous phase, and the sheared oil phase is 1:(1~5):(1~25), and the total flow rate of the three phases is 1~10 ml / min.

[0009] Preferably, the immiscible components include any one of an immiscible combination of oils and fats, an aqueous solution and an oil, and an aqueous solution and an immiscible oil, wherein the aqueous solution refers to an aqueous solution containing a hydrophilic but non-lipophilic substance.

[0010] Preferred immiscible oil combinations include combinations of silicone oil and castor oil, combinations of white oil and castor oil, combinations of C15-19 alkane and castor oil, and combinations of soybean oil and silicone oil, wherein C15-19 alkane is a mixture of alkanes with 15 to 19 carbon atoms. Preferably, the aqueous solution includes one or both of dextran aqueous solution and PEG aqueous solution.

[0011] Preferably, in the aqueous phase, the curing material includes sodium alginate and calcium ethylenediaminetetraacetate; in the shear oil, the initiator includes oil-soluble organic or inorganic acids.

[0012] More preferably, the shearing oil includes an organic solvent, and the initiator is dissolved in the organic solvent; Organic solvents include one or more of white oil, isononyl isononanoate, and glyceryl caprylate / capric acid.

[0013] More preferably, the aqueous phase further includes one or more of a water-soluble pigment, a thickener, and a water-soluble surfactant; the sheared oil further includes one or two of an oil-soluble pigment and an oil-soluble surfactant.

[0014] In a second aspect, the present invention proposes an application of the above-described combination of immiscible systems in the cosmetics field.

[0015] In a third aspect, the present invention provides a microfluidic device comprising a mixture conduit, an aqueous phase conduit, and a shearing grease conduit arranged coaxially, wherein one end of the mixture conduit is located inside the aqueous phase conduit and the outer diameter of the mixture conduit is smaller than the inner diameter of the aqueous phase conduit, and one end of the aqueous phase conduit is located inside the shearing grease conduit and the outer diameter of the aqueous phase conduit is smaller than the inner diameter of the shearing grease conduit. The mixture pipeline is divided into a first cavity and a second cavity. The first cavity and the second cavity are connected by a material conveying hole. The second cavity is connected to the water phase pipeline. The number of material conveying holes is ≥1.

[0016] Preferably, the inner diameter of the mixture pipe is 1~2 mm, the inner diameter of the water phase pipe is 2~3 mm, and the inner diameter of the shear pipe is 4~5 mm.

[0017] More preferably, the diameter of the feed hole is 0.6~1 mm and the length of the feed hole is 0.8~1.5 mm.

[0018] Beneficial effects: This invention utilizes real-time homogenization and microfluidic technology to continuously and uniformly encapsulate immiscible components within microspheres, achieving combined property of immiscible components and obtaining layered microbead products with innovative functions, which are more aesthetically pleasing. Attached Figure Description

[0019] Figure 1 The diagram shown is a process flow chart of the present invention.

[0020] Figure 2 The diagram shows a schematic of the microfluidic device of the present invention. Figure 1 .

[0021] Figure 3 The diagram shows a schematic of the microfluidic device of the present invention. Figure 2 .

[0022] Reference numerals: 1-mixture pipe, 2-aqueous phase pipe, 3-shearing grease pipe, 4-feeding port, 5-homogeneous structure, 6-first cavity, 7-second cavity. Detailed Implementation

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the specific implementation methods of the present invention will be described below with reference to the accompanying drawings. Obviously, the drawings described below are merely some embodiments of the present invention. For those skilled in the art, other drawings and other implementation methods can be obtained based on these drawings without any creative effort.

[0024] like Figure 1 As shown, this invention proposes a combined characterization process for immiscible systems, comprising the following steps: S1. Mixing and homogenization: Mixing and homogenizing two or more immiscible components to obtain an immiscible mixture; S2, Microfluidic shearing: Using an immiscible mixture as the internal phase, it is immediately introduced into a microfluidic device after homogenization. At the same time, the aqueous phase and shearing grease are also introduced into the microfluidic device to perform droplet shearing and form an oil-in-water-in-oil composite droplet. The shearing grease contains an initiator, and the aqueous phase contains a curing material triggered by the initiator. During the shearing droplet process, the initiator in the shearing grease reacts and solidifies with the curing material in the aqueous phase, forming microbeads that encapsulate an immiscible mixture.

[0025] In step S1, multiple immiscible components are mixed and homogenized in a predetermined ratio. After subsequent shearing to form oil cores, the immiscible components within the microspheres also conform to the predetermined ratio. Preferably, after mixing two or more immiscible components, a first homogenization process is performed, followed by a second homogenization process after introducing the microfluidic device. Shearing is then performed immediately after the second homogenization process. Corresponding to the process steps of this invention, the first homogenization process is performed in step S1 to achieve complete mixing of multiple immiscible components. Preferably, this mixing can be performed within a homogenizer. The second homogenization process is performed in step S2 to ensure that the multiple oils in the composite droplets during shearing meet the design requirements and avoid any discrepancies in the ratio. This second homogenization process can be performed within the inner phase channel of the microfluidic device.

[0026] Preferably, the immiscible components include any one of an immiscible combination of oils and fats, an aqueous solution and an oil, and an aqueous solution and an immiscible oil, wherein the aqueous solution refers to an aqueous solution containing a hydrophilic but non-lipophilic substance.

[0027] According to the above description, immiscible components actually include three situations: (1) Immiscible oil combination: a mixture of two or more immiscible oils; (2) Aqueous solution and oil combination: a mixture of aqueous solution and oil phase, in which the effective components in the aqueous solution (i.e., hydrophilic but not lipophilic substances) do not dissolve in the oil phase, thus forming an immiscible system; (3) Aqueous solution and immiscible oil combination: an aqueous solution mixed with two or more immiscible oils, in which the effective components in the aqueous solution do not dissolve in any of the oils.

[0028] It should be noted that when immiscible components contain aqueous solutions, the aqueous solution and the aqueous phase will not dissolve during shearing, but rather form an aqueous two-phase system. An aqueous two-phase system is a two-phase aqueous solution system spontaneously formed by two or more water-soluble components under specific concentration conditions due to thermodynamic incompatibility. This system differs from traditional oil-water extraction systems; both phases use water as the main solvent, exhibiting characteristics such as low interfacial tension, rapid mass transfer, mild system environment, and the absence of organic solvents. Conventional water-soluble polymers, inorganic salts, and ionic liquids can form homogeneous and stable aqueous solutions when dissolved individually in water. However, when two hydrophilic components are combined and reach a critical concentration, steric hindrance, hydration competition, and mutual repulsion exist between molecules. The mixing entropy of the system is insufficient to maintain a homogeneous state, thus spontaneously separating into two immiscible aqueous phases with different properties.

[0029] Preferably, the immiscible oil combinations include combinations of silicone oil and castor oil, combinations of white oil and castor oil, combinations of C15-19 alkanes and castor oil, and combinations of soybean oil and silicone oil. Preferably, the mass ratio of the two oil components in the combination is (0.1~1):(0.1~1). Wherein, C15-19 alkanes are a mixture of alkanes with 15 to 19 carbon atoms.

[0030] Preferably, the aqueous solution comprises one or both of a dextran aqueous solution and a PEG aqueous solution. More preferably, the dextran aqueous solution contains 4-10% dextran by mass. Even more preferably, the PEG aqueous solution contains 6-20% PEG by mass, and most preferably 4%.

[0031] In step S2, the immiscible mixture serves as the inner phase. The immiscible mixture is first sheared into droplets by the aqueous phase. Subsequently, the aqueous phase, encapsulating the droplet-shaped immiscible mixture, is sheared by the shearing grease to form composite droplets. During this process, the aqueous phase reacts with the components in the shearing grease, causing the aqueous phase to solidify and encapsulate the immiscible mixture located in the core.

[0032] In step S2, the flow rate ratio of the immiscible mixture phase, the aqueous phase, and the sheared oil phase is 1:(1~5):(1~25), and the total flow rate of the three phases is 1~10 ml / min.

[0033] In this invention, the curing material in the aqueous phase and the initiator in the shearing grease are matched. The curing material in the aqueous phase is a water-soluble material, and the initiator in the shearing grease is an oil-soluble material. Any matching curing material and initiator that can achieve the above-mentioned functions is applicable to this invention. Preferably, in the aqueous phase, the curing material includes sodium alginate and calcium ethylenediaminetetraacetate. Preferably, the mass fraction of the curing material in the aqueous phase is 0.1-3%, and in the shearing grease, the initiator includes an oil-soluble organic acid or inorganic acid. Preferably, the mass fraction of the initiator in the shearing grease is 0.05-2%. Preferably, the initiator includes one or more of naphthenic acids, dodecylbenzenesulfonic acid, salicylic acid, oleic acid, and acetic acid; more preferably, the initiator is acetic acid. Sodium alginate and calcium EDTA undergo a cross-linking reaction under acidic conditions to form a three-dimensional network structure, namely an oil core, which is locked in the aqueous phase. In the aqueous phase that forms the gel structure, the oil core is fixed in a spherical state. Due to the density differences of different oils and the effect of tension, the oil core will gradually stratify in the future, thus forming a layered structure similar to a cocktail.

[0034] This invention utilizes real-time homogenization and microfluidic technology to continuously and uniformly encapsulate immiscible mixtures within microspheres, thereby achieving the combined properties of immiscible mixtures and obtaining layered microbead products with innovative functions, which are more aesthetically pleasing.

[0035] Preferably, in step S2, the aqueous phase further includes a water-soluble pigment, which is used to adjust the color of the composite droplets to produce products with different appearances. Preferably, the mass fraction of the water-soluble pigment in the aqueous phase is 0.1% to 1%.

[0036] More preferably, the aqueous phase further includes a thickener. More preferably, the thickener includes one or more of carbomer, cellulose, and xanthan gum. Preferably, the mass fraction of the thickener in the aqueous phase is 0.1-2%.

[0037] More preferably, the aqueous phase also includes one or more water-soluble surfactants, such as Tween 80, sodium lauryl ether sulfate, sodium lauroamphoacetate, fatty alcohol polyoxyethylene ether-7, PEG-40 hydrogenated castor oil, and cetyltrimethylammonium chloride. Preferably, the mass fraction of the water-soluble surfactant in the aqueous phase is 0.5% to 5%.

[0038] Preferably, in step S2, the shearing oil includes an organic solvent, that is, the main component of the shearing oil is an organic solvent, and the initiator is dissolved in the organic solvent. More preferably, the organic solvent includes one or more of white oil, isononyl isononanoate, and glyceryl caprylate.

[0039] More preferably, the sheared oil also includes an oil-soluble pigment, which is used to adjust the color of the composite droplets to produce products with different appearances. Preferably, the mass fraction of the oil-soluble pigment in the sheared oil is 0.1% to 1%.

[0040] More preferably, the shearing oil also includes one or more oil-soluble surfactants, such as Span 80, CO40, polyglycerol-3 diisostearate, polyglycerol-2 oleate, PGPR, etc. Preferably, the mass fraction of the oil-soluble surfactant in the shearing oil is 0.5% to 5%.

[0041] In this invention, appropriate surfactants are added to both the sheared oil and the aqueous phase to stabilize the droplets and prevent them from coalescing. The addition of surfactants to the sheared oil stabilizes the intermediate aqueous droplets, ensuring the stability of the aqueous phase. The aqueous phase dissolves the hydrophilic surfactant, while the oil dissolves the lipophilic surfactant. This combination of multiple surfactants enhances the stabilizing effect.

[0042] like Figure 2-3 As shown, based on the process of the present invention, the present invention also proposes a suitable microfluidic device, including a mixture pipe, an aqueous phase pipe and a shearing grease pipe arranged coaxially. One end of the mixture pipe is located inside the aqueous phase pipe, and the outer diameter of the mixture pipe is smaller than the inner diameter of the aqueous phase pipe. One end of the aqueous phase pipe is located inside the shearing grease pipe, and the outer diameter of the aqueous phase pipe is smaller than the inner diameter of the shearing grease pipe.

[0043] The working principle of this microfluidic device is as follows: an aqueous phase is introduced into the aqueous phase pipeline, and shearing grease is introduced into the shearing grease pipeline. The homogenized, immiscible mixture is then fed into the aqueous phase through the mixture pipeline. At the end face of the mixture pipeline, the immiscible mixture is sheared by the aqueous phase, forming droplets. Subsequently, the aqueous phase containing these droplets is sheared by the shearing grease at the end face of the aqueous phase pipeline, forming composite droplets. Based on this microfluidic device, continuous production can be achieved, and the shearing grease containing composite droplets can be collected. After settling, the various immiscible components in the oil core gradually separate into layers.

[0044] Preferably, the inner diameter of the mixing pipe is 1 to 2 mm, and more preferably, the diameter of the mixing pipe is 1.5 mm.

[0045] Preferably, the inner diameter of the water phase pipe is 2 to 3 mm, and more preferably, the diameter of the water phase pipe is 2.5 mm.

[0046] Preferably, the diameter of the shearing pipe is 4-5 mm, and more preferably, the diameter of the shearing pipe is 4 mm.

[0047] Furthermore, the microfluidic device preferably has a homogenization function, which allows the immiscible mixture to be homogenized and mixed again before being sheared by the aqueous phase, thus avoiding the agglomeration of oils and the resulting large changes in the oil composition ratio in the oil core. Specifically, the interior of the mixture pipeline is divided into a first cavity and a second cavity, which are connected to the first cavity through a feed hole. The second cavity is connected to the aqueous phase pipeline, wherein the diameter of the feed hole is 0.6~1 mm.

[0048] In this invention, the number of conveying holes is ≥1. When there is only one conveying hole, it is preferably coaxially arranged with the mixing pipe, and the diameter of the conveying hole is necessarily smaller than the inner diameter of the mixing pipe. When there are ≥2 conveying holes, the multiple conveying holes are evenly distributed. Preferably, the number of conveying holes is 1.

[0049] When the immiscible mixture is fed into the mixing pipeline, it first enters the first chamber and then enters the second chamber through the feed hole. During this process, since the feed hole is a narrow-diameter channel, the immiscible mixture undergoes a sudden change in flow channel size as it flows through the feed hole. At the narrowing point, the flow velocity increases sharply, generating a jet. This breaks down and homogenizes the immiscible mixture entering the second chamber. Subsequently, the immiscible mixture entering the second chamber is sheared by the aqueous phase.

[0050] In a mixing pipeline, a feed orifice that is too small will result in excessive flow resistance, while a feed orifice that is too large will lead to poor homogenization. The preferred diameter of the feed orifice is 0.6 to 1 mm, and more preferably 0.8 mm.

[0051] Within the mixing pipeline, the distance between the first and second cavities, i.e., the length of the feed orifice, is subject to certain requirements. The feed orifice is situated within a homogeneous structure, and its axial length is equivalent to the thickness of this homogeneous structure. Excessive thickness of the homogeneous structure increases flow resistance and leads to a significant increase in pressure within the mixing pipeline; conversely, insufficient thickness poses a risk of the structure being ruptured by the material. Preferably, the length of the feed orifice is 0.8–1.5 mm. More preferably, the length of the feed orifice is 1 mm.

[0052] In addition to the microfluidic devices mentioned above, devices capable of preparing oil-in-water-in-oil composite droplets should also be within the scope of this invention.

[0053] The technical solution of the present invention will be described in detail below with specific embodiments.

[0054] Example 1 In this embodiment, in the microfluidic device, the diameter of the mixing pipe is 1 mm, the diameter of the aqueous phase pipe is 2 mm, and the diameter of the shearing pipe is 4 mm. The diameter of the feed orifice in the mixing pipe is 0.8 mm, and the length of the feed orifice is 1 mm.

[0055] In this embodiment, the immiscible oils are silicone oil and castor oil.

[0056] The steps in this embodiment are as follows: S1. Mixing and homogenizing: Mix silicone oil and castor oil in a mass ratio of 1:1 and perform pre-homogenization. The rotation speed is 7000 rpm and the homogenization process is 3 min to obtain an immiscible mixture. S2. Microfluidic shearing: Using an immiscible mixture as the internal phase, it is immediately introduced into a microfluidic device after homogenization. At the same time, the aqueous phase and shearing oil are also introduced into the microfluidic device. The flow rate ratio of the immiscible mixture, aqueous phase and shearing oil is controlled at 1:3:8, and the total flow rate is controlled at 6 ml / min to perform droplet shearing and form an oil-in-water-in-oil composite droplet. In the aqueous phase, sodium alginate has a mass percentage of 0.7% and calcium ethylenediaminetetraacetate has a mass percentage of 0.01%; in the sheared oil, the organic solvent is glyceryl caprylate and octanoate, and the mass percentage of acetic acid is 0.1%.

[0057] Collect the composite droplets and let them stand to obtain a microbead product with a bilayer internal phase.

[0058] Example 2 In this embodiment, in the microfluidic device, the diameter of the mixing pipe is 1 mm, the diameter of the aqueous phase pipe is 2 mm, and the diameter of the shearing pipe is 4 mm. The diameter of the feed orifice in the mixing pipe is 0.8 mm, and the length of the feed orifice is 1 mm.

[0059] In this embodiment, the immiscible oils are silicone oil, castor oil, and a dextran solution (mass concentration of 8%).

[0060] The steps in this embodiment are as follows: S1. Mixing and homogenizing: Mix silicone oil, castor oil and dextran solution in a mass ratio of 1:1:1 and perform pre-homogenization. The rotation speed is 7000 rpm and the homogenization process is 3 min to obtain an immiscible mixture. S2. Microfluidic shearing: Using an immiscible mixture as the internal phase, it is immediately introduced into a microfluidic device after homogenization. At the same time, the aqueous phase and shearing oil are also introduced into the microfluidic device. The flow rate ratio of the immiscible mixture, aqueous phase and shearing oil is controlled at 1:3:8, and the total flow rate is controlled at 6 ml / min to perform droplet shearing and form an oil-in-water-in-oil composite droplet. In the aqueous phase, sodium alginate has a mass percentage of 0.7% and calcium ethylenediaminetetraacetate has a mass percentage of 0.01%; in the sheared oil, the organic solvent is glyceryl caprylate and octanoate, and the mass percentage of acetic acid is 0.1%.

[0061] Collect the composite droplets and let them stand to obtain a microbead product with a three-layered internal phase.

[0062] The embodiments provided by the present invention have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of the present invention, and the descriptions of the embodiments above are only for the purpose of helping to understand the core ideas of the present invention. It should be noted that those skilled in the art can make several improvements and modifications to the present invention without departing from the principles of the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.

Claims

1. A combined property treatment process for immiscible systems, characterized in that, Includes the following steps: S1. Mixing and homogenization: Mixing and homogenizing two or more immiscible components to obtain an immiscible mixture; S2, Microfluidic shearing: Using an immiscible mixture as the internal phase, it is immediately introduced into a microfluidic device after homogenization. At the same time, the aqueous phase and shearing grease are also introduced into the microfluidic device to perform droplet shearing and form an oil-in-water-in-oil composite droplet. The shearing grease contains an initiator, and the aqueous phase contains a curing material triggered by the initiator. During the shearing droplet process, the initiator in the shearing grease reacts and solidifies with the curing material in the aqueous phase to form microbeads that encapsulate an immiscible mixture. The flow rate ratio of the immiscible mixture phase, the aqueous phase, and the sheared oil phase is 1:(1~5):(1~25), and the total flow rate of the three phases is 1~10 ml / min.

2. The combined characterization process for the immiscible system according to claim 1, characterized in that, Two or more immiscible components are mixed and then subjected to a first homogenization process. After being introduced into a microfluidic device, a second homogenization process is performed. Shearing is then performed immediately after the second homogenization process is completed.

3. The combined characterization process for the immiscible system according to claim 1, characterized in that, Immiscible components include any one of the following: an immiscible combination of fats and oils, an aqueous solution and a fat or oil, and an aqueous solution and an immiscible fat or oil. The aqueous solution refers to an aqueous solution containing a hydrophilic but non-lipophilic substance.

4. The combined characterization process for the immiscible system according to claim 3, characterized in that, Immiscible oil combinations include combinations of silicone oil and castor oil, white oil and castor oil, C15-19 alkane and castor oil, and soybean oil and silicone oil. C15-19 alkane is a mixture of alkanes with 15 to 19 carbon atoms.

5. The combined characterization process for the immiscible system according to claim 3, characterized in that, Aqueous solutions include one or both of dextran aqueous solutions and PEG aqueous solutions.

6. The combined characterization process for the immiscible system according to claim 1, characterized in that, In the aqueous phase, the curing materials include sodium alginate and calcium ethylenediaminetetraacetate; in the shear oil, the initiator includes oil-soluble organic or inorganic acids.

7. The combined characterization process for the immiscible system according to claim 6, characterized in that, Shearing oils contain organic solvents, and the initiator is dissolved in the organic solvent; Organic solvents include one or more of white oil, isononyl isononanoate, and glyceryl caprylate / capric acid.

8. The combined characterization process for the immiscible system according to claim 1, characterized in that, The aqueous phase also includes one or more water-soluble pigments, thickeners, and water-soluble surfactants; the sheared oil also includes one or two oil-soluble pigments and oil-soluble surfactants.

9. The application of a combined characterization process for an immiscible system, characterized in that, The combined characterization process of the immiscible system according to any one of claims 1-8 is used in the cosmetics field.

10. A microfluidic device for a combined characterization process of the immiscible system according to any one of claims 1-8, characterized in that, It includes a mixture pipe, a water phase pipe, and a shearing grease pipe arranged coaxially. One end of the mixture pipe is inside the water phase pipe, and the outer diameter of the mixture pipe is smaller than the inner diameter of the water phase pipe. One end of the water phase pipe is inside the shearing grease pipe, and the outer diameter of the water phase pipe is smaller than the inner diameter of the shearing grease pipe. The mixture pipeline is divided into a first cavity and a second cavity. The first cavity and the second cavity are connected by a material conveying hole. The second cavity is connected to the water phase pipeline. The number of material conveying holes is ≥1.

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