Energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device

Abstract

This invention relates to the field of CIP (Chemical In-Place Cleaning) technology, specifically to an energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment. The device includes multiple pushing mechanisms, left-right swinging mechanisms, multiple rotating nozzles, and guide tubes connected to the tails of the rotating nozzles. Multiple clearance notches are provided on the reaction vessel, and the top of the guide tube extends through these notches. The pushing mechanism includes a clamping wheel and a pushing roller that hold the outer edge of the guide tube. This energy-saving closed-loop CIP in-situ cleaning device can push the guide tube upwards and rotate it at any angle, enabling thorough cleaning of the corners and crevices inside the pharmaceutical vessel to prevent drug residue. After the guide tube rotates, it can be moved at any angle via the pushing mechanism, and after resetting, the guide tube can be pushed upwards, allowing the rotating nozzles to adaptively reset and adjust to the top inner side of the reaction vessel.

Description

Technical Field

[0001] This invention relates to the field of CIP in-situ cleaning technology, specifically to an energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment. Background Technology

[0002] CIP, or Clean In-Situ, refers to a technology that automatically completes cleaning, disinfection, and rinsing in a closed system without disassembling equipment, pipes, or tanks. The cleaning equipment includes nozzles connected to the tank and external water, acid, and alkali supply systems. During cleaning, the tank interior is cleaned through water washing, alkali washing, acid washing, and then water washing again. Water washing lasts 3–5 minutes at 60°C. Alkali washing lasts 15–30 minutes using 1–2% NaOH at 60–80°C. Acid washing lasts 10–20 minutes using 0.5–1% nitric acid / phosphoric acid at 60–70°C. The final water wash lasts 5–10 minutes using hot, pure water. However, current technologies generally only use rotating nozzles for fixed cleaning of the tank, leaving no corners or crevices untreated. This is particularly problematic in pharmaceutical tanks, where inadequate cleaning can lead to contamination of the next batch of medication if left untreated. Therefore, it is necessary to design an energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment, which can thoroughly clean the corners and crevices inside the pharmaceutical tank to avoid drug residue. Summary of the Invention

[0003] To address the aforementioned technical shortcomings, the purpose of this invention is to provide an energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment, which can thoroughly clean the corners and crevices inside the pharmaceutical tank, thus preventing drug residues.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: The present invention provides an energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment, including multiple pushing mechanisms, left and right swinging mechanisms, multiple rotating nozzles, and guide tubes connected to the tails of the rotating nozzles. Multiple clearance notches are provided on the reaction tank, and the top of the guide tube extends through the clearance notches. The pushing mechanism includes a clamping wheel and a pushing roller that clamp the outer edge of the guide tube. The clamping wheel is connected to an elastic pushing mechanism for pushing it closer to the guide tube. The side of the pushing roller is connected to a rotating mechanism for driving its rotation. The surface of the pushing roller is rough. The left and right swinging mechanism includes a pushing ring and a displacement frame. The displacement frame is installed on the top of the reaction tank and can move horizontally left and right through the pushing mechanism. The pushing ring is rotatably installed on the displacement frame. The top of the guide tube is inserted into the pushing ring. When the guide tube is in a vertical state, the outer edge of the guide tube is in contact with one side of the pushing roller.

[0005] Preferably, the rotating mechanism includes a rotating support, a drive gear ring, an end face gear, and multiple gear sets. The end face gear is rotatably mounted on the top of the reaction vessel via the rotating support. The drive gear ring meshes with the end of the end face gear. The drive gear ring is connected to a drive motor. The end face gear is driven by a push roller via a gear set. The push roller is coaxially connected to one of the gears in the gear set via a connecting shaft.

[0006] Preferably, the elastic pushing mechanism includes a slide rail, a slide plate, a spring, and a guide post. The slide plate is horizontally slidable and mounted on the slide rail. The clamping wheel is rotatably mounted on the slide plate. One end of the guide post is fixedly connected to the slide plate. The spring provides an elastic force to the clamping wheel near the guide tube.

[0007] Preferably, a vertical frame is fixedly installed on the top of the reaction vessel, and a slide rail is horizontally fixedly installed on the vertical frame. A guide hole is provided on the guide column for the guide column to slide.

[0008] Preferably, the pushing mechanism includes multiple individual swing mechanisms and a lifting mechanism. Each individual swing mechanism includes a guide plate, a connecting column, a guide plate, and a second guide column. The guide plate has an inclined groove for the connecting column to slide. The connecting column is fixedly connected to the displacement frame. The second guide column is fixedly installed on the side of the displacement frame. The guide plate is installed on the lifting mechanism. The second guide column is slidably connected to the guide plate. The lifting mechanism is connected to multiple guide plates.

[0009] Preferably, the lifting mechanism includes an electric push rod, a telescopic tube, and multiple supports. The guide plate is fixedly installed on the supports. Each pair of supports is fixedly connected by a connecting beam. The electric push rod and the telescopic tube are both fixedly installed on the top of the reaction vessel. The sliding end of the telescopic tube is fixedly connected to the connecting beam, and the output end of the electric push rod is fixedly connected to the connecting beam.

[0010] Preferably, a rubber sealing gasket is fitted over the top of the clearance notch, and a rigid guide ring is fixedly installed in the middle of the rubber sealing gasket, with the guide tube sleeved on the outer edge of the rigid guide ring.

[0011] Preferably, the surface of the push roller is provided with a rubber anti-slip sleeve.

[0012] Preferably, a connecting flange is provided at the top of the guide tube, and the connecting flange is connected to the main interface of the liquid supply equipment.

[0013] Preferably, the height of the connecting beam and the support is greater than the height of the feed inlet at the top of the reaction vessel.

[0014] The beneficial effects of this invention are as follows: This energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device can push the guide tube upwards, and when pushed to any angle, it can drive the guide tube to rotate, which can thoroughly clean the corners and gaps inside the pharmaceutical tank, avoiding drug residue. After the guide tube rotates to a certain angle, it can be driven to move at any angle by the push mechanism. After resetting, the guide tube can be pushed upwards, so that the rotating nozzle can adaptively reset and adjust to the top of the inner side of the reaction tank. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a perspective view of the present invention.

[0017] Figure 2 This is a partial three-dimensional structural diagram of the present invention.

[0018] Figure 3 This is a partial three-dimensional structural diagram of the left-right swinging mechanism.

[0019] Figure 4 This is a 3D view of the rubber gasket in its installed state.

[0020] Figure 5 This is a schematic diagram of the three-dimensional structure after the rotating nozzle has been adjusted to swing.

[0021] Figure 6 This is a three-dimensional structural diagram of an elastic actuation mechanism.

[0022] Explanation of reference numerals in the attached drawings: 1. Reaction vessel; 1a. Clearance notch; 2. Rotating nozzle; 3. Guide tube; 4. Pushing mechanism; 4a. Clamping wheel; 4b. Pushing roller; 4c. Rotating mechanism; 4c1. Rotating support; 4c2. Drive gear ring; 4c3. End face gear; 4c4. Gear set; 4d. Elastic pushing mechanism; 4d1. Slide rail; 4d2. Slide plate; 4d3. Spring; 4d4. Guide post one; 4e. Vertical frame; 5. Left and right swinging mechanism; 5a. Pushing ring; 5b. Displacement frame; 5d. Guide plate; 5e. Connecting column; 5f. Guide plate; 5h. Guide post two; 5j. Lifting mechanism; 5j1. Connecting beam; 5j2. Electric push rod; 5j3. Telescopic tube; 5j4. Support; 7. Rubber sealing gasket; 7a. Rigid guide ring. Detailed Implementation

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Example: This invention provides an energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment, such as... Figure 1-6 As shown, the reaction vessel 1 includes multiple pushing mechanisms 4, left and right swinging mechanisms 5, multiple rotating nozzles 2, and a guide tube 3 connected to the tail of the rotating nozzle 2. Multiple clearance notches 1a are provided on the reaction vessel 1. The top of the guide tube 3 extends through the clearance notches 1a. The pushing mechanism 4 includes a clamping wheel 4a and a pushing roller 4b that clamp the outer edge of the guide tube 3. The clamping wheel 4a is connected to an elastic pushing mechanism 4d for pushing it closer to the guide tube 3. The side of the pushing roller 4b is connected to a rotating mechanism 4c for driving it to rotate. The surface of the pushing roller 4b is rough. The clamping wheel 4a tightly presses the guide tube 3 against the pushing roller 4b. The pushing roller 4b rotates, thus pushing the guide tube 3 downward by friction. The left-right swaying mechanism 5 includes a pushing ring 5a and a displacement frame 5b. The displacement frame 5b is mounted on the top of the reaction tank 1 and can move horizontally left and right via the pushing mechanism. The pushing ring 5a is rotatably mounted on the displacement frame 5b. The top of the guide tube 3 is inserted into the pushing ring 5a. When the guide tube 3 is in a vertical state, its outer edge is in contact with one side of the push roller 4b. This feature indicates that the guide tube 3 is in a vertical state. When the guide tube 3 is in a vertical state, the rotation of the push roller 4b will push the guide tube 3 to move vertically downwards. It should be noted that if the pushing ring 5a were not limiting the guide tube 3, the guide tube 3 would rotate and deviate when the push roller 4b rotates. The pushing ring 5a, the push roller 4b, and the clamping wheel 4a form a triangular trend, which limits the guide tube 3. When the displacement frame 5b drives the push ring 5a to swing left and right, the clamping wheel 4a presses against the guide tube 3, causing the guide tube 3 to rotate against the push roller 4b. As the guide tube 3 moves, it drives the push ring 5a to rotate along the hinge point with the displacement frame 5b. This rotation of the guide tube 3 changes the spray direction of the rotating nozzle 2 at its bottom, altering the original spray pattern. Figure 1 The spray direction shown is switched to the following: Figure 5The spray direction is shown. This sprayed water flow can thoroughly clean all parts of the interior of the reaction tank 1, and the guide tube 3 can rotate at any position during descent. Most importantly, the length of the guide tube 3 can be automatically adjusted as needed. For both longer and shorter reaction tanks 1, the length of the guide tube 3 can be changed to adapt to different equipment. Furthermore, this structure can set and simultaneously control the displacement of multiple rotating nozzles 2. During reset, even if the downward displacement of the guide tube 3 by the push roller 4b results in frictional failure, the upward push of the guide tube 3 during reset will drive the push roller 4b to rotate several more times, ensuring that the rotating nozzles 2 contact the inner top of the reaction tank 1. This guarantees a consistent initial position during each descent, i.e., it has an adaptive reset function.

[0025] The rotating mechanism 4c includes a rotating support 4c1, a drive gear ring 4c2, an end face gear 4c3, and multiple gear sets 4c4. The end face gear 4c3 is rotatably mounted on the top of the reaction vessel 1 via the rotating support 4c1. The drive gear ring 4c2 meshes with the end of the end face gear 4c3. The drive gear ring 4c2 is connected to a drive motor. The end face gear 4c3 is driven by the gear sets 4c4 and connected to the push roller 4b. The push roller 4b is coaxially connected to one of the gears in the gear set 4c4 via a connecting shaft. Driven by the motor, the drive gear ring 4c2 drives the end face gear 4c3 to rotate. The end face gear 4c3 then drives the multiple gear sets 4c4 to work simultaneously, thereby driving the push roller 4b to rotate. The push roller 4b then drives the guide tube 3 to move vertically up and down through friction.

[0026] The gear set 4c4 includes a bevel gear that meshes with the end face gear 4c3 and a pair of spur gears, one of which is coaxially connected to the bevel gear and the other is coaxially connected to the push roller 4b.

[0027] The elastic pushing mechanism 4d includes a slide rail 4d1, a slide plate 4d2, a spring 4d3, and a guide post 4d4. The slide plate 4d2 is horizontally slidable on the slide rail 4d1, and the clamping wheel 4a is rotatably mounted on the slide plate 4d2. One end of the guide post 4d4 is fixedly connected to the slide plate 4d2. The spring 4d3 provides an elastic force to the clamping wheel 4a near the guide tube 3. The spring 4d3 applies a pushing force to the clamping wheel 4a, and during the pushing process, the slide rail 4d1 guides the movement of the slide plate 4d2.

[0028] A vertical frame 4e is fixedly installed on the top of the reaction vessel 1. A slide rail 4d1 is horizontally fixed on the vertical frame 4e. A guide hole is provided on the guide post 4d4 for sliding. One end of the spring 4d3 abuts against the slide plate 4d2, and the other end of the spring 4d3 abuts against the vertical frame 4e.

[0029] The pushing mechanism includes multiple individual swing mechanisms and a lifting mechanism 5j. Each individual swing mechanism includes a guide plate 5d, a connecting column 5e, a guide plate 5f, and a second guide column 5h. The guide plate 5d has an inclined groove for the connecting column 5e to slide. The connecting column 5e is fixedly connected to the displacement frame 5b. The second guide column 5h is fixedly installed on the side of the displacement frame 5b. The guide plate 5f is installed on the lifting mechanism 5j, and the second guide column 5h is slidably connected to the guide plate 5f. The lifting mechanism 5j is connected to multiple guide plates 5f. By pushing upwards through the lifting mechanism 5j, the displacement frame 5b can be moved up and down as a whole. The pushing ring 5a will slide on the guide tube 3. While the displacement frame 5b is moving, it will drive the connecting column 5e to slide along the inclined groove. The inclined groove will convert the vertical thrust into a horizontal thrust, causing the displacement frame 5b to slide horizontally along the guide plate 5f. By adopting this horizontal pushing method, rather than a direct left-right pushing method, this pushing method can connect multiple guide tubes 3 at the same time, so as to control the rotation angle of multiple guide tubes 3 simultaneously, and enable multiple rotating nozzles 2 at their bottom to change the spray direction of the water flow simultaneously.

[0030] The lifting mechanism 5j includes an electric push rod 5j2, a telescopic tube 5j3, and multiple supports 5j4. A guide plate 5f is fixedly installed on each support 5j4. Each pair of supports 5j4 is fixedly connected by a connecting beam 5j1. The electric push rod 5j2 and the telescopic tube 5j3 are both fixedly installed on the top of the reaction tank 1. The sliding end of the telescopic tube 5j3 is fixedly connected to the connecting beam 5j1, and the output end of the electric push rod 5j2 is fixedly connected to the connecting beam 5j1. Controlling the electric push rod 5j2 causes it to push the connecting beam 5j1 upwards. The connecting beam 5j1 then drives the supports 5j4 upwards, which in turn drives the guide plate 5f upwards, allowing the multiple connected displacement frames 5b to move upwards synchronously.

[0031] A rubber sealing gasket 7 covers the top of the clearance notch 1a, and a rigid guide ring 7a is fixedly installed in the middle of the rubber sealing gasket 7. The guide tube 3 is sleeved on the outer edge of the rigid guide ring 7a. The clearance notch 1a is sealed by the rigid guide ring 7a. However, since the guide tube 3 will rotate, the rubber sealing gasket 7 is the only option to allow the rigid guide ring 7a to move. The rubber sealing gasket 7 has a pleated structure.

[0032] The surface of the push roller 4b is provided with a rubber anti-slip sleeve. The guide tube 3 is pushed downward or upward vertically by the rubber anti-slip sleeve on the surface of the push roller 4b.

[0033] A connecting flange is provided at the top of the guide tube 3, which connects to the main interface of the liquid supply equipment. The main interface will discharge aqueous solution, alkaline solution, and acid solution. The discharged solution will enter along the guide tube 3 and be sprayed out from the rotating nozzle 2, which is a rotating nozzle that is driven to rotate by the water flow during rotation.

[0034] The height of the connecting beam 5j1 and the support 5j4 is greater than the height of the feed inlet at the top of the reaction vessel 1. Through the action of the telescopic pipe 5j3 and the electric push rod 5j2, the connecting beam 5j1 and the support 5j4 can be suspended and supported, maintaining a certain distance between them and the feed inlet, ensuring that the metal pipe can be connected to the feed inlet.

[0035] This energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device can push the guide tube 3 upwards, and can drive the guide tube 3 to rotate at any angle, which can thoroughly clean the corners and gaps inside the pharmaceutical tank to avoid drug residue. After the guide tube 3 rotates, it can be driven to move at any angle by the push mechanism 4. After resetting, the guide tube 3 can be pushed upwards, so that the rotating nozzle 2 can adaptively reset and adjust to the top of the inner side of the reaction tank 1.

[0036] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. An energy-saving closed-loop CIP in-situ cleaning device for pharmaceutical equipment, characterized in that, The reaction vessel (1) includes multiple pushing mechanisms (4), left and right swinging mechanisms (5), multiple rotating nozzles (2), and a guide tube (3) connected to the tail of the rotating nozzles (2). Multiple clearance notches (1a) are provided on the reaction vessel (1). The top of the guide tube (3) extends through the clearance notches (1a). The pushing mechanism (4) includes a clamping wheel (4a) and a pushing roller (4b) that clamp the outer edge of the guide tube (3). The clamping wheel (4a) is connected to an elastic pushing mechanism (4d) for pushing it closer to the guide tube (3). The side of the pushing roller (4b) A rotating mechanism (4c) for driving its rotation is connected. The surface of the push roller (4b) is rough. The left and right swinging mechanism (5) includes a push ring (5a) and a displacement frame (5b). The displacement frame (5b) is installed on the top of the reaction vessel (1) and can move horizontally left and right through the push mechanism. The push ring (5a) is rotatably installed on the displacement frame (5b). The top of the guide tube (3) is inserted into the push ring (5a). When the guide tube (3) is in a vertical state, the outer edge of the guide tube (3) is in contact with one side of the push roller (4b).

2. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 1, characterized in that, The rotating mechanism (4c) includes a rotating support (4c1), a drive gear ring (4c2), an end gear (4c3), and multiple gear sets (4c4). The end gear (4c3) is rotatably mounted on the top of the reaction vessel (1) via the rotating support (4c1). The drive gear ring (4c2) meshes with the end of the end gear (4c3). The drive gear ring (4c2) is connected to a drive motor. The end gear (4c3) is driven and connected to the push roller (4b) via the gear set (4c4). The push roller (4b) is coaxially connected to one of the gears in the gear set (4c4) via a connecting shaft.

3. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 2, characterized in that, The elastic pushing mechanism (4d) includes a slide rail (4d1), a slide plate (4d2), a spring (4d3), and a guide post (4d4). The slide plate (4d2) is horizontally slidably mounted on the slide rail (4d1), and the clamping wheel (4a) is rotatably mounted on the slide plate (4d2). One end of the guide post (4d4) is fixedly connected to the slide plate (4d2), and the spring (4d3) provides an elastic force to the clamping wheel (4a) close to the guide tube (3).

4. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 3, characterized in that, A vertical frame (4e) is fixedly installed on the top of the reaction vessel (1), and a slide rail (4d1) is horizontally fixed on the vertical frame (4e). A guide hole is provided on the guide post (4d4) for the guide post (4d4) to slide.

5. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 1, characterized in that, The pushing mechanism includes multiple individual swing mechanisms and a lifting mechanism (5j). Each individual swing mechanism includes a guide plate (5d), a connecting column (5e), ​​a guide plate (5f), and a second guide column (5h). The guide plate (5d) has an inclined groove for the connecting column (5e) to slide. The connecting column (5e) is fixedly connected to the displacement frame (5b). The second guide column (5h) is fixedly installed on the side of the displacement frame (5b). The guide plate (5f) is installed on the lifting mechanism (5j). The second guide column (5h) is slidably connected to the guide plate (5f). The lifting mechanism (5j) is connected to multiple guide plates (5f).

6. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 5, characterized in that, The lifting mechanism (5j) includes an electric push rod (5j2), a telescopic tube (5j3), and multiple supports (5j4). The guide plate (5f) is fixedly installed on the support (5j4). Each pair of supports (5j4) is fixedly connected by a connecting beam (5j1). The electric push rod (5j2) and the telescopic tube (5j3) are both fixedly installed on the top of the reaction vessel (1). The sliding end of the telescopic tube (5j3) is fixedly connected to the connecting beam (5j1), and the output end of the electric push rod (5j2) is fixedly connected to the connecting beam (5j1).

7. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 1, characterized in that, The top of the clearance notch (1a) is covered with a rubber sealing gasket (7), and a rigid guide ring (7a) is fixedly installed in the middle of the rubber sealing gasket (7). The guide tube (3) is sleeved on the outer edge of the rigid guide ring (7a).

8. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 1, characterized in that, The surface of the push roller (4b) is provided with a rubber anti-slip sleeve.

9. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 1, characterized in that, The top of the guide tube (3) is provided with a connecting flange, which is connected to the main interface of the liquid supply equipment.

10. The energy-saving closed-loop pharmaceutical equipment CIP in-situ cleaning device as described in claim 6, characterized in that, The height of the connecting beam (5j1) and the support (5j4) is greater than the height of the top feed inlet of the reaction vessel (1).

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