Temperate bug control agent and temperate bug control method

Abstract

Provided is a temperate bug control agent that has excellent control effects on drug-resistant temperate bugs. The temperate bug control agent of the present invention for controlling drug-resistant temperate bugs comprises a specific pyrethrin compound having a vapor pressure of 6.6661 x 10 －3 -6.6661 x 10-3 Pa or more at 25°C, and is used for contact control or space control. The temperate bug control agent of the present invention for controlling drug-resistant temperate bugs comprises a specific pyrethrin compound having a vapor pressure of 6.6661 x 10 －3 -6.6661 x 10-3 Pa or more at 25°C, and is used for contact control or space control. The temperate bug control agent of the present invention for controlling drug-resistant temperate bugs comprises a specific pyrethrin compound having a vapor pressure of 6.6661 x 10 －3 -6.6661 x 10-3 Pa or more at 25°C, and is used for contact control or space control. The temperate bug control agent of the present invention for controlling drug-resistant temperate bugs comprises a specific pyrethrin compound having a vapor pressure of 6.6661 x 10 －3 -6.6661 x 10-3 Pa or more at 25°C, and is used

Description

Technical Field

[0001] This invention relates to a modifier for controlling drug-resistant temperate bed bugs (Cimex lectularius) and a method for controlling temperate bed bugs. Background Technology

[0002] In recent years, the damage caused by temperate bed bugs has become a problem, requiring targeted measures. Temperate bed bugs have different habits from other pests; they hide during the day in narrow crevices and cracks in bedding, walls, etc., and emerge at night to feed on blood. Therefore, considering the difficulty in delivering pesticides such as DEET to the habitats of temperate bed bugs, the following method is proposed: applying the pesticide with a deliberately reserved space relative to the habitat, thereby preventing the spread of temperate bed bugs from their habitat to the surrounding area (see Patent Document 1).

[0003] On the other hand, among temperate bed bugs, there exist resistant temperate bed bugs that are resistant to insecticidal components such as pyrethroid compounds. Therefore, in order to control resistant temperate bed bugs, it is proposed to use tetrafluorobenzyl as an insecticidal compound containing a polyfluorobenzyl moiety alone, and in combination with other insecticides (insecticides other than those containing a polyfluorobenzyl moiety) (see Patent Document 2).

[0004] Existing technical documents

[0005] Patent documents

[0006] Patent Document 1: Japanese Patent Application Publication No. 2015-214507

[0007] Patent Document 2: Japanese Patent Publication No. 2016-503426 Summary of the Invention

[0008] The problem that the invention aims to solve

[0009] While Patent Document 1 describes controlling temperate bedbugs by placing the pesticide in suitable locations, it does not focus on the pesticide's effectiveness itself, making it difficult to claim high control efficacy. Furthermore, it does not address the control effect on pyrethroid-resistant temperate bedbugs, leaving its effectiveness unclear.

[0010] In Patent Document 2, although tetrafluorobenzyl is used as the agent, it is difficult to say that tetrafluorobenzyl itself has a high control effect on resistant temperate bed bugs.

[0011] The present invention is proposed in view of the above-mentioned problems, and its purpose is to provide a temperate bed bug control agent and a temperate bed bug control method with excellent control effect against drug-resistant temperate bed bugs.

[0012] Methods for solving problems

[0013] To address the aforementioned issues, the inventors conducted in-depth research and discovered that, as in Patent Document 2, if a pyrethroid compound simply possesses a polyfluorobenzyl moiety (structure) in its molecule, it cannot exhibit high control efficacy against resistant temperate bedbugs. Based on this insight, those skilled in the art conducted further research and discovered that pyrethroid compounds with specific vapor pressures exhibit high control efficacy against resistant temperate bedbugs, thus completing this invention.

[0014] The temperate bed bug control agent of the present invention, which is used to solve the above-mentioned problems, is characterized in that it is used to control drug-resistant temperate bed bugs, and contains a vapor pressure of 6.6661 × 10⁻⁶ at 25°C. -3 Specific pyrethroid compounds with a Pa level above 1.

[0015] According to this formulation, the temperate bed bug control agent has a vapor pressure of 6.6661 × 10⁻⁶ at 25°C. -3 Certain pyrethroid compounds with a Pa level or higher exhibit excellent control effects against resistant temperate bedbugs.

[0016] In the temperate bed bug control agent of the present invention, the above-mentioned specific pyrethroid compounds are preferably propargyl and / or fenvalerate.

[0017] According to this temperate bed bug control agent, the vapor pressure at 25°C is 6.6661 × 10⁻⁶. -3 The specific pyrethroid compounds with a Pa level above 1 are propargite and / or fenvalerate, which can further improve the control effect against resistant temperate bedbugs.

[0018] The temperate bed bug control agent of the present invention is preferably used for contact control or spatial control.

[0019] According to the temperate bed bug control agent of this formulation, when the temperate bed bug control agent is for contact control, by adhering the temperate bed bug control agent to the surface of the ground, wall and / or objects where resistant temperate bed bugs may lurk or appear, the temperate bed bug control agent can contact the resistant temperate bed bugs, resulting in a vapor pressure of 6.6661 × 10 at 25°C. -3Specific pyrethroid compounds at Pa or higher act on resistant temperate bed bugs. When the temperate bed bug control agent is used for space control, by spraying or evaporating the agent into the space where resistant temperate bed bugs may exist, the agent can volatilize within the space, allowing the aforementioned specific pyrethroid compounds to act on the resistant bed bugs in this atmosphere. By using the temperate bed bug control agent for contact or space control in this way, the specific pyrethroid compounds can act more appropriately on the resistant temperate bed bugs, thus further improving the control effect.

[0020] In the temperate bed bug control agent of the present invention, the preferred amount of the specific pyrethroid compound is 1 to 30 w / v.

[0021] According to the temperate bed bug control agent of this formulation, by adjusting the amount of a specific pyrethroid compound within the above-mentioned range, the control effect against resistant temperate bed bugs can be further improved.

[0022] In the temperate bed bug control agent of the present invention, the above-mentioned temperate bed bug control agent is preferably used for contact control, and the application amount is set such that the specific pyrethroid compound adheres to the target surface at a concentration of 15 mg / m². 2 above.

[0023] According to the temperate bed bug control agent of this formulation, when the temperate bed bug control agent is used for contact control, by setting its application amount to such that the amount of a specific pyrethroid compound adhering to the target surface is within the range mentioned above, the contact control effect can be further improved.

[0024] In the temperate bed bug control agent of the present invention, the above-mentioned temperate bed bug control agent is preferably used for space control, and the application amount is set such that the application amount of the above-mentioned specific pyrethroid compound in the target space is 1000 mg / m². 3 above.

[0025] According to the temperate bed bug control agent of this formulation, when the temperate bed bug control agent is used for space control, by setting its application amount to such that the application amount of a specific pyrethroid compound to the target space is within the range mentioned above, the space control effect can be further improved.

[0026] Another feature of the present invention for controlling temperate bed bugs to solve the above-mentioned problems is that, for controlling drug-resistant temperate bed bugs, it includes a contact application step in which the temperate bed bug control agent is applied to the surface of the ground, wall and / or articles where the drug-resistant temperate bed bugs may lurk or appear.

[0027] According to the temperate bed bug control method of this invention, by adhering the temperate bed bug repellent to the surface of the ground, walls, and / or objects where resistant temperate bed bugs may lurk or appear, the repellent can contact the resistant temperate bed bugs, resulting in a vapor pressure of 6.6661 × 10⁻⁶ at 25°C. -3 Specific pyrethroid compounds at Pa levels act on resistant temperate bed bugs. By implementing such methods to control temperate bed bugs, resistant temperate bed bugs can be eradicated.

[0028] Another feature of the present invention for controlling temperate bed bugs to solve the above-mentioned problems is that, for controlling drug-resistant temperate bed bugs, it includes a space application step in which the temperate bed bug control agent is sprayed, evaporated, or volatilized into the space where the drug-resistant temperate bed bugs may exist.

[0029] According to the temperate bed bug control method of this invention, by spraying, evaporating, or volatilizing a temperate bed bug repellent into a space where resistant temperate bed bugs may exist, the repellent can be volatilized within the space, achieving a vapor pressure of 6.6661 × 10⁻⁶ at 25°C under this atmosphere. -3 Specific pyrethroid compounds at Pa levels act on resistant temperate bed bugs. By implementing such methods to control temperate bed bugs, resistant temperate bed bugs can be eradicated.

[0030] In the temperate bed bug control method of the present invention, the above-mentioned space application step preferably includes a setting application step, in which the temperate bed bug control agent or a drug carrier containing the temperate bed bug control agent is set on the ground, walls and / or objects where the above-mentioned drug-resistant temperate bed bugs may lurk or appear, or in their vicinity.

[0031] According to the temperate bed bug control method of this configuration, by means of a spatial application step, a temperate bed bug repellent or a carrier containing the temperate bed bug repellent is placed on the ground, walls and / or objects where resistant temperate bed bugs may lurk or appear, or in their vicinity, so that the vapor pressure at 25°C from the temperate bed bug repellent is 6.6661 × 10⁻⁶. -3 Specific pyrethroid compounds at concentrations above Pa act on resistant temperate bed bugs. This allows resistant temperate bed bugs to be exposed to higher concentrations of the insecticide, thus achieving a greater control effect. Detailed Implementation

[0032] The following describes embodiments of the temperate bed bug control agent and method of the present invention. However, the present invention is not intended to be limited to the configurations described in the embodiments below.

[0033] [Temperate Bedbug Control Agent]

[0034] The temperate bed bug control agent of this embodiment is a temperate bed bug control agent used to control drug-resistant temperate bed bugs. It should be noted that the term "control" in this specification means repelling, knocking down, or killing drug-resistant temperate bed bugs.

[0035] Drug-resistant temperate bed bugs

[0036] The resistant temperate bed bugs targeted by the temperate bed bug control agent of this invention are those that are difficult to control with pyrethroid compounds. Previously, pyrethroid compounds such as deltamethrin, permethrin, and deltamethrin were used for the control of temperate bed bugs; however, in recent years, resistant temperate bed bugs have been discovered that are resistant to these pyrethroid compounds. Therefore, in this invention, such resistant temperate bed bugs are targeted for control. Specifically, the term "resistant temperate bed bug" in this specification refers to bed bugs that are resistant to pyrethroid compounds (with a vapor pressure of 6.6661 × 10⁻⁶ at 25°C). -3 Temperate bedbugs resistant to pyrethroid compounds other than specific pyrethroid compounds (i.e., conventional pyrethroid compounds, especially permethrin) at Pa or above.

[0037] The vapor pressure at <25℃ is 6.6661 × 10⁻⁶. -3 Pyrethroid compounds above Pa >

[0038] The temperate bedbug control agent of this embodiment contains a vapor pressure of 6.6661 × 10⁻⁶ at 25°C. -3 Pa (5.0 × 10) -5 Pyrethroid compounds (hereinafter referred to as "specific pyrethroid compounds") of 1.02658 mmHg or higher can be used as insecticidal ingredients. Specific pyrethroid compounds exhibit lethal activity even against resistant temperate bed bugs, a novel insight previously unknown. By including specific pyrethroid compounds in temperate bed bug control agents, excellent control effects can be achieved even against resistant temperate bed bugs that are difficult to control with pyrethroid compounds such as deltamethrin, permethrin, and cypermethrin. Examples of specific pyrethroid compounds include, for instance, propofol (1.02658 × 10⁻⁶ mmHg). -2 Pa (7.7×10) -5 mmHg), fenpyroxene (2.19981×10 -2 Pa (16.5×10) -5 (mmHg) Here, the unit of vapor pressure is 1 mmHg = 1.33322 × 10⁻⁶. 2Pa, with the unit mmHg indicated in parentheses after Pa. Vapor pressure can be determined, for example, by the Donovan method (Journal of Chromatography A. Volume 749, Issues 1-2, 1996, Pages 123-129, “New method forestimating vapor pressure by the use of gas chromatography”). Profenofibrate and fenpyrethroids are highly effective against resistant temperate bedbugs and are suitable specific pyrethroid compounds in this invention. It should be noted that these specific pyrethroid compounds contain optical isomers and geometric isomers based on chiral carbon atoms, which are also included in the specific pyrethroid compounds of this invention.

[0039] The amount of a specific pyrethroid compound in the temperate bed bug control agent is not particularly limited, but is preferably 0.1 to 100 w / v, more preferably 0.5 to 80 w / v, even more preferably 1 to 60 w / v, and particularly preferably 1 to 30 w / v.

[0040] <Other Ingredients>

[0041] (Other insecticidal ingredients)

[0042] Temperate bed bug control agents may contain, in addition to specific pyrethroid compounds, transfluthrin, metofluthrin, momfluorothrin, phthalthrin, resmethrin, cyfluthrin, phenothrin, permethrin, cyphenothrin, allethrin, prallethrin, and furamethrin. Insecticides include pyrethrin, bifenthrin, ethfenprox, pyrethrin, and other pyrethrin compounds; silicon compounds such as silafluofen; organophosphorus compounds such as dichlorvos and fenitrothion; carbamate compounds such as propoxur; diamide compounds such as broflanilide; and neonicotinoid compounds such as dinotefuran and imidacloprid. Temperate bedbug control agents can also contain other compounds in addition to specific pyrethrin compounds to create comprehensive insecticides (insecticide products).

[0043] When the temperate bed bug control agent contains the other insecticidal ingredients mentioned above, the total amount of the specific pyrethroid compound and the other insecticidal ingredients is not particularly limited, but is preferably 0.1 to 100 w / v%, more preferably 0.5 to 80 w / v%, and even more preferably 1 to 60 w / v.

[0044] (solvent)

[0045] In the temperate bedbug control agent of this embodiment, a solvent can be incorporated. Examples of solvents include water, as well as various organic solvents such as alcohols, ketones, glycols, glycol ethers, higher fatty acid esters, and hydrocarbons. As an alcohol solvent, lower alcohols with 2 to 3 carbon atoms, such as ethanol and isopropanol, are preferred, with ethanol being more preferred. As a ketone solvent, acetone is preferred. As a glycol solvent, hexanediol, 1,3-butanediol, propylene glycol, and dipropylene glycol can be used. As a glycol ether solvent, diethylene glycol monobutyl ether and propylene glycol monomethyl ether can be used. As a higher fatty acid ester solvent, solvents with a total carbon number of 13 to 30 are preferred, with solvents with a total carbon number of 16 to 24 being more preferred; examples include isopropyl myristate, butyl myristate, hexyl laurate, and isopropyl palmitate. As a hydrocarbon solvent, examples include n-alkanes and isoalkanes.

[0046] (surfactant)

[0047] In the temperate bedbug control agent of this embodiment, a surfactant or the like can be used as a solubilizer. The surfactant can be any of a cationic surfactant, anionic surfactant, or nonionic surfactant.

[0048] (Ingredients other than those mentioned above)

[0049] In the drug-resistant temperate bedbug control agent of this embodiment, antifungal agents, antibacterial agents, bactericides, fragrances, deodorizers, stabilizers, antistatic agents, defoamers, excipients, etc., targeting molds and fungi, may also be appropriately combined. Examples of antifungal agents, antibacterial agents, and bactericides include juniper alcohol, 2-mercaptobenzothiazole, 2-(4-thiazolyl)benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one, cyprofen, 3-methyl-4-isopropylphenol, and o-phenylphenol. As fragrance agents, examples include orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, sweet orange oil, jasmine oil, cypress oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, phenethyl alcohol, pentyl cinnamaldehyde, p-isopropylbenzaldehyde, benzyl acetate, and other aromatic components, as well as chlorinol, known as "green fragrance," and chlorinaldehyde, which are blending fragrance components.

[0050] <Formulation>

[0051] The temperate bedbug control agent of this embodiment can be used in various formulations (products) depending on the location where resistant temperate bedbugs may exist and the surrounding conditions. These formulations can include, for example, oils, emulsions, wettable powders, suspensions (water suspensions, water emulsions, etc.), microcapsules, powders, granules, tablets, aerosols, sprays, carbon dioxide formulations, heated vaporizers (fumigants, insecticidal incense sticks, electrothermal insecticidal tablets, wick-type heated vaporizers, etc.), non-heated vaporizers (resin vaporizers, fan-type volatiles, etc.), and tablets. From the viewpoint of ease of application, aerosols, sprays, non-heated vaporizers, and heated vaporizers are preferred.

[0052] The temperate bedbug control agent of this embodiment can be used for contact control or space control, for example.

[0053] When using temperate bed bug control agents for contact control, the agents can be applied to surfaces of the ground, walls, and / or objects where resistant temperate bed bugs may lurk or appear (hereinafter referred to as the target surface). In this case, the temperate bed bug control agent can be used in formulations such as powders, granules, aerosols, sprays, heated vaporized products, unheated vaporized products, and flakes. By allowing the temperate bed bug control agent to act directly on resistant temperate bed bugs or to adhere to (contact with) the target surface, the agent can contact the resistant temperate bed bugs, thereby enabling the specific pyrethroid compound to exert its effect. More specifically, for example, (1) for powders and granules, they are applied to the resistant temperate bed bugs and the target surface; (2) for aerosols and sprays, they are sprayed onto the resistant temperate bed bugs and the target surface; (3) for heated and unheated vaporized products, the temperate bed bug repellent is evaporated or dispersed from these products into the space and adhered to the target surface in the space; (4) for sheet products, the target surface is wiped with the product or the sheet product itself is placed on the target surface. In these ways, the temperate bed bug repellent can be applied directly or indirectly to the resistant temperate bed bugs, thereby achieving control. From the perspective of being able to efficiently apply the temperate bed bug repellent to the resistant temperate bed bugs and the target surface, powders, granules, aerosols, sprays, and sheet products are preferred. In particular, from the perspective of ease of use, aerosols and sprays are preferred.

[0054] When using a temperate bed bug control agent for space control, it can be sprayed or evaporated into the space where resistant temperate bed bugs may exist. In this case, the temperate bed bug control agent can be used in the form of powder, granules, aerosol products, spray products, heated evaporated products, unheated evaporated products, tablet products, etc. These products allow the temperate bed bug control agent to evaporate into the space, where a specific pyrethroid compound acts on the resistant temperate bed bugs in the atmosphere. More specifically, aerosol products, spray products, heated evaporated products, and unheated evaporated products can control resistant temperate bed bugs by directly applying the temperate bed bug control agent into the space through spraying or evaporation. For other formulations, the temperate bed bug control agent can be evaporated from the application surface after application in the same manner as in contact control (1) and (4) described above. It should be noted that aerosol, spray, heated vaporization, and non-heated vaporization products can not only be applied directly to the space as a temperate bed bug repellent, but also, similar to the contact control methods mentioned above, be applied by adhering to the ground, walls, objects, etc., allowing the temperate bed bug repellent to slowly evaporate from the adhered surface, thereby controlling resistant temperate bed bugs. Considering the efficient application of temperate bed bug repellents into the space, aerosol, spray, heated vaporization, and non-heated vaporization products are preferred, especially considering ease of use. It should be noted that heated vaporization and non-heated vaporization products, by being directly placed on or near specific items such as the ground, walls, and suitcases where resistant temperate bed bugs may lurk or appear (setting up an application step), expose resistant temperate bed bugs to higher concentrations of the repellent, thus achieving a higher control effect. Such prevention and control measures are specifically referred to as "setting up prevention and control".

[0055] By applying temperate bed bug control agents to contact or space control in this way, specific pyrethroid compounds can be applied more appropriately to resistant temperate bed bugs, thus further improving control effectiveness.

[0056] When using the temperate bedbug control agent of this embodiment in the form of an aerosol product, the aerosol product mainly consists of a pressure-resistant container, a spray valve, and a spray nozzle. The spray valve is connected to a spray button, which is an actuating part for spraying a solution (concentrate) containing a specific pyrethroid compound, other arbitrary co-occurring ingredients, and various solvents. The spray nozzle has a spray port that sprays the solution from the aerosol container to the outside. Furthermore, the spray valve is preferably a conventional continuous spray valve capable of spraying a fixed amount of solution each time, and a metered spray valve is preferred. The spray volume of the solution when the spray button of the metered spray aerosol product is pressed once is preferably set to 0.1 to 3 mL, more preferably 0.2 to 1 mL. Within this range, the spray particles sprayed from the metered spray valve can effectively exert a control effect. Regarding the particle size of the sprayed particles, the 50% particle size (D50) in the volumetric cumulative distribution at 25°C and a spraying distance of 15 cm is preferably set to 10–120 μm, more preferably 15–100 μm, and even more preferably 20–85 μm. Within this range, in the aforementioned contact or spatial application, the sprayed particles can reliably adhere to the surface of the target object (including resistant temperate bed bugs), or allow the specific pyrethroid compound to act on the resistant temperate bed bugs in a volatile or vaporized state.

[0057] The nozzle diameter of the spray nozzle is preferably set to 0.2–1.0 mm, more preferably 0.7–1.0 mm. Within this range, a suitable spray pattern can be obtained, facilitating the adhesion of the sprayed particles to the target object (including resistant temperate bed bugs), allowing the specific pyrethroid compound to act directly on the resistant temperate bed bugs, either directly or in a volatile or vaporized state. In such an aerosol product, the specific pyrethroid compound can be adjusted to contain 1–30 w / v% in the concentrate. With this range, even a small spray volume can allow the specific pyrethroid compound to act on resistant temperate bed bugs.

[0058] When using the temperate bed bug control agent of this embodiment in the form of a spray product, a spray product can be obtained by selecting a stock solution (pesticide solution) containing a specific pyrethroid compound, other arbitrary co-occurring components, various solvents, and a spray agent to be used as needed, and sealing them in a pressure-resistant container or a trigger-type or pump-type spray container. The spray product can be sprayed onto the ground, walls, and / or surfaces of objects where resistant temperate bed bugs may lurk or appear (contact application), or sprayed into spaces where resistant temperate bed bugs may exist (space application). This allows the specific pyrethroid compound contained in the spray particles to act on the resistant temperate bed bugs. In such a spray product, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v% in the stock solution. If adjusted to such a range, even a small spray volume can allow the specific pyrethroid compound to act on the resistant temperate bed bugs.

[0059] When using the temperate bedbug control agent of this embodiment in the form of a non-heated vaporized product, a stock solution (pesticide solution) containing a specific pyrethroid compound, any combined components, and various solvents is loaded onto a carrier by means of coating, impregnation, kneading, etc., thereby obtaining a non-heated vaporized product. The non-heated vaporized product can be applied to the ground, walls, and / or objects where resistant temperate bedbugs may lurk or appear, or to their vicinity, through evaporation at room temperature or using a fan or other blowing mechanism (placement application), or through evaporation into spaces where resistant temperate bedbugs may exist (space application). This allows the specific pyrethroid compound to act on the resistant temperate bedbugs. In such a non-heated vaporized product, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v% in the stock solution. If adjusted to such a range, even a small loading amount can allow the specific pyrethroid compound to act on the resistant temperate bedbugs.

[0060] There are no particular limitations on the carriers used in non-heated vaporized products; however, examples include clays such as kaolin, diatomaceous earth, bentonite, and acid clay; inorganic minerals such as talc, ceramics, or calcium carbonate; sublimable substances that are solid at room temperature, such as trioxane, naphthalene, p-dichlorobenzene, camphor, and adamantane; as well as paper, wool, silk, cotton, hemp, pulp, various polymers, nonwoven fabrics, cellulose foams, and porous materials. Examples of polymers include films, solid or fibrous molded bodies formed from polyethylene, polypropylene, acrylonitrile / butadiene / styrene copolymer (ABS), ethylene / vinyl acetate copolymer (EVA), ethylene / methyl methacrylate copolymer (EMMA), styrene-based diblock polymers, styrene-based triblock polymers, thermoplastic elastomers (TPE, TPO), silicone rubber, and silicone resins. Among these considerations, sheet-like or board-like paper, pulp, fibers, and felt are preferred as carriers, considering their ability to allow the medicinal liquid to penetrate an absorbent carrier and to utilize volatility based on natural evaporation. To thicken these carriers, multiple thin sheets of material can be layered. Furthermore, to ensure that pulp boards and felts efficiently absorb the medicinal liquid while maintaining their shape, they can be bent, perforated, or embossed. Additionally, the medicinal liquid can be carried on adhesive carriers with a sealing layer for bonding. These carriers can be used directly or stored in breathable containers, and appropriate fixing mechanisms (adhesive seals, hooks and loops, etc.) can be used during use.

[0061] When using the temperate bed bug control agent of this embodiment in the form of a heat-evaporating product, a stock solution (medicinal liquid) containing a specific pyrethroid compound, other arbitrary co-formulated components, and various solvents is contained in a container and heated by a heat source, thereby obtaining a liquid-type (wick-type) heat-evaporating product. Alternatively, the aforementioned medicinal liquid can be impregnated into a carrier as described above and heated by a heat source, thereby obtaining a pad-type heat-evaporating product. The heat-evaporating product allows the temperate bed bug control agent to adhere to the surface of the ground, walls, and / or objects where resistant temperate bed bugs may lurk or appear (contact application), or to evaporate into spaces where resistant temperate bed bugs may exist (space application). This allows the specific pyrethroid compound to act on resistant temperate bed bugs. In such a heat-evaporating product, the specific pyrethroid compound can be adjusted to contain 1 to 30 w / v in the stock solution. If adjusted to this range, even a small amount of pesticide solution can enable specific pyrethroid compounds to act on resistant temperate bedbugs.

[0062] When using the temperate bed bug control agent of this embodiment for space application, the space used can be any space where resistant temperate bed bugs may exist; there are no particular limitations. It can be an indoor or outdoor space. However, considering the potential for greater control effectiveness, indoor spaces are preferred. Examples of indoor spaces include those smaller than 2.0m². 3 The gap space ranges from 2.0 to 18.8m. 3 The narrow space on both sides, equivalent to a room of 4.5 to 8 tatami mats, has a volume of 18.8 to 33.3 m². 3 Approximately (area 7.5–13.3 m²) 2 An interior space with a height of 2.2–3.0m, equivalent to a room of 8–16 tatami mats, has a volume of 33.3–66.6m². 3 Approximately (area 13.3–26.6 m²) 2 Spacious indoor spaces (2.2–3.0 m high) are suitable. The temperate bedbug control agent of this embodiment is particularly suitable for spaces with a volume of 33.3 m³. 3 It performs exceptionally well in the following types of narrow, confined, and interior spaces, especially in narrow spaces. Examples of narrow spaces include suitcases (or clothes inside suitcases), closets, Japanese-style closets, wardrobes, sideboards, furniture, and gaps between furniture pieces. Examples of confined spaces include toilets, bathrooms, storage rooms, and car interiors. Examples of interior spaces include living rooms, dining rooms, and storage rooms.

[0063] [Methods for controlling bedbugs in temperate zones]

[0064] In the method for controlling temperate bed bugs in this embodiment, the above-mentioned temperate bed bug control agent is used to control drug-resistant temperate bed bugs.

[0065] One method for controlling temperate bed bugs includes a contact application step, in which the aforementioned temperate bed bug repellent is applied to the surface of the ground, walls, and / or objects where resistant temperate bed bugs may lurk or appear. In this case, a temperate bed bug repellent prepared in a suitable formulation, as illustrated above, can be used, for example, an aerosol, spray, or heat-dispersible formulation. According to this temperate bed bug control method, by applying the aforementioned temperate bed bug repellent to the surface of the ground, walls, and / or objects where resistant temperate bed bugs may lurk or appear, the repellent can contact the resistant temperate bed bugs, allowing the specific pyrethroid compound to exert its effect. By implementing such a temperate bed bug control method, resistant temperate bed bugs can be controlled. Regarding the dosage of the temperate bed bug repellent, it is preferable that the amount of the specific pyrethroid compound adhering to the target surface is 15 mg / m². 2 The above, more preferably 20 mg / m²2 The above is further preferred to be 50 mg / m³. 2 The above applies to the use of temperate bed bug control agents for contact control. By setting the application amount of the temperate bed bug control agent to ensure that the amount of a specific pyrethroid compound adhering to the target surface is within the range described above, the contact control effect can be further improved.

[0066] Another method for controlling temperate bed bugs includes a space application step, in which the aforementioned temperate bed bug repellent is sprayed or evaporated into a space where resistant temperate bed bugs may exist. In this case, a temperate bed bug repellent prepared in an appropriate formulation, as illustrated above, can be used, such as an aerosol, spray, non-heated vaporizing agent, or heated vaporizing agent. According to this temperate bed bug control method, by spraying or evaporating the temperate bed bug repellent into a space where resistant temperate bed bugs may exist, the repellent can be made to evaporate within the space, allowing specific pyrethroid compounds to act on the resistant temperate bed bugs in this atmosphere. By implementing such a temperate bed bug control method, resistant temperate bed bugs can be controlled.

[0067] In particular, by implementing a spatial application process (installation control) that places heated and non-heated vaporized products near the ground, walls, and / or objects where resistant temperate bed bugs may lurk or appear, resistant temperate bed bugs can be exposed to higher concentrations of the temperate bed bug control agent, thus achieving a higher control effect. As for the amount of temperate bed bug control agent applied to the target space, a volatilization rate of the specific pyrethroid compound in the target space is preferably 0.5 mg / m². 3 The above, more preferably 1 mg / m² 3 The above is further preferred to be 3 mg / m³. 3 The above, especially preferred, is 10 mg / m². 3 That's all. Furthermore, especially when applying temperate bed bug control agents by adhering them to the ground, walls, objects, etc., it is preferable to use a specific pyrethroid compound at a dosage of 1000 mg / m² for the target space. 3 The above, more preferably 2000 mg / m² 3 The above is further preferred to be 3000 mg / m². 3 The above, especially preferred, is 5000 mg / m². 3 The above applies to the use of temperate bed bug control agents for space control. By setting the application rate of the temperate bed bug control agent to the range described above for the application rate of a specific pyrethroid compound to the target space, the space control effect can be further improved.

[0068] Example

[0069] The present invention will be further described in detail below through embodiments and comparative examples; however, the present invention is not limited to the embodiments.

[0070] [Raw Materials Used]

[0071] (Insecticidal ingredient)

[0072] • Specific pyrethroid compounds:

[0073] Procymidone

[0074] Enzyme

[0075] • Non-specific pyrethroid compounds:

[0076] Tetrafluorobenzene

[0077] Methoxybenzylfluorometholone

[0078] Permethrin

[0079] Non-pyrethroid compounds:

[0080] Oxyphenidone

[0081] (solvent)

[0082] Ketone solvents:

[0083] acetone

[0084] • Alcohol-based solvents:

[0085] ethanol

[0086] Isopropanol

[0087] [Experimental Insects]

[0088] (Temperate bedbugs)

[0089] • Pesticide-resistant temperate bed bugs (pesticide-resistant temperate bed bugs, adults):

[0090] Drug-resistant temperate bed bugs (I): Itami strain (a strain that shows more than 30,000 times resistance to permethrin compared to the sensitive strain [Japanese environmental strain])

[0091] Drug-resistant temperate bed bugs (II): Amagasaki strain (a strain that shows more than 30,000 times resistance to permethrin compared to the sensitive strain [Japanese environmental strain])

[0092] Drug-resistant temperate bed bugs (III): Osaka strain (a strain that shows more than 30,000 times resistance to permethrin compared to the sensitive strain [Japanese environmental strain])

[0093] • Sensitive temperate bed bugs (non-drug-resistant temperate bed bugs):

[0094] Japanese Environmental Series

[0095] (German cockroach)

[0096] • Pyrethroid-resistant German cockroaches (resistant cockroaches, adult females):

[0097] Compared to the Fukuchiyama strain (a sensitive strain [Dai Nippon strain]), this strain exhibits more than 49 times the resistance to permethrin.

[0098] • Sensitive German cockroach (non-resistant cockroach, adult female):

[0099] Dai Nippon strain

[0100] [Experimental Example 1] Control effect based on contact application

[0101] The control efficacy of contact application of temperate bed bug control agents against resistant and non-resistant temperate bed bugs was compared. The same evaluation method was also used to evaluate the control efficacy against resistant and non-resistant cockroaches.

[0102] <Examples 1-6, Comparative Examples 1-6, Reference Example 1>

[0103] According to the formulations shown in Tables 1-2, insecticidal ingredients and solvents were combined to obtain temperate bed bug control agents for use as liquid pesticides in Examples 1-6, Comparative Examples 1-6, and Reference Example 1. The control efficacy of the temperate bed bug control agents from Examples 1-6, Comparative Examples 1-6, and Reference Example 1 against resistant temperate bed bugs (resistant temperate bed bug (I), resistant temperate bed bug (II), resistant temperate bed bug (III)), non-resistant temperate bed bugs, resistant cockroaches, and non-resistant cockroaches based on contact application was evaluated using the following evaluation methods.

[0104] <Control Efficacy Test Based on Contact Application>

[0105] Use a glass petri dish with a diameter of 9cm and a height of 2cm (volume: 127.17cm). 3 =0.00012717m 3 Add the pesticide solution to a glass petri dish to achieve the dosage of the insecticide shown in Tables 1 and 2, and evenly coat the entire bottom surface of the dish. Then, place a given number of test insects into the bottom of the dish, allowing the pesticide solution (insecticide) to directly contact the insects. After 24 hours from the time of insect introduction, collect the insects into a plastic cup lined with filter paper. After 72 hours from the time of insect introduction (48 hours from the time of collection), count the number of dead insects and calculate the mortality rate (%). Thereafter, evaluate the control effect according to the following criteria.

[0106] (Judgment Criteria)

[0107] A: The mortality rate is over 90%.

[0108] B: The mortality rate is above 80% but less than 90%.

[0109] C: Fatality less than 80%

[0110]

[0111]

[0112] Examples 1-3, 5, and 6 of Examples 1-6, which contain specific pyrethroid compounds as insecticidal ingredients, showed excellent control efficacy against resistant temperate bedbugs (I)-(III) when applied by contact, receiving an "A" rating (lethality rate: 100% or 90%). Although the control results for resistant temperate bedbugs (I)-(III) in Example 4 were not evaluated, based on the relationship between Examples 1-3 containing 2 w / v% propofol and Example 5 containing 10 w / v propofol, it can be inferred that if the relationship between Example 4 containing 2 w / v% enythrin and Example 6 containing 10 w / v enythrin also shows a similar trend, then Example 4, like Example 6, would also exhibit excellent control efficacy against resistant temperate bedbugs (I)-(III). Based on these results, it can be concluded that Examples 1-6 are effective against all resistant temperate bedbugs. Furthermore, Examples 1-3 show that even when acetone, ethanol, and isopropanol are used as solvents, the control effect of the specific pyrethroid compound against resistant temperate bed bugs is not hindered, and it exerts a useful control effect against resistant temperate bed bugs (I) to (III). Based on this result, it can be considered that the type of solvent does not affect the control effect against resistant temperate bed bugs. It should be noted that in Examples 1-3, propofol was used as the specific pyrethroid compound; however, when using specific pyrethroid compounds other than propofol, the type of solvent will not affect the control effect against resistant temperate bed bugs, and this is considered to be the same.

[0113] Examples 1-6 all achieved an "A" rating for control of non-resistant temperate bed bugs (lethality rate: 100%). The specific pyrethroid compounds showed excellent control effects not only against resistant temperate bed bugs but also against non-resistant temperate bed bugs.

[0114] Based on the results of Examples 5 and 6 of Examples 1-6, when the content of the specific pyrethroid compound was high, the control effect on resistant cockroaches was rated "C" (lethality rate of Example 5: 0%, mortality rate of Example 6: 10%), indicating extremely low control efficacy. However, the control effect on non-resistant cockroaches was rated "A" (lethality rate: 100%), showing excellent control efficacy. On the other hand, based on the results of Examples 1-3, when the content of the specific pyrethroid compound was low, the control effect on resistant cockroaches was rated "C" (lethality rate: 0%), indicating extremely low control efficacy. Furthermore, the control effect on non-resistant cockroaches was also rated "C" (lethality rate of Example 1: 7.5%, mortality rate of Example 2: 10%, mortality rate of Example 3: 10%), indicating extremely low control efficacy. The results indicate that when the concentration of a specific pyrethroid compound is low enough to be ineffective against non-resistant cockroaches, it also fails to control resistant cockroaches. Although it is essentially ineffective against non-resistant cockroaches, it exhibits excellent control against resistant temperate bedbugs (I) to (III), as mentioned above. Considering this, it is clear that even at low concentrations, the contact application-based control effect of the specific pyrethroid compound is highly specific, particularly for temperate bedbugs. It should be noted that while propofol was used as the specific pyrethroid compound in Examples 1-3, the aforementioned effect (effective against resistant temperate bedbugs despite being ineffective against non-resistant cockroaches) when the specific pyrethroid compound is set at a low concentration is also considered to be achieved when using a specific pyrethroid compound other than propofol.

[0115] In contrast, in Comparative Examples 1-6, which contained tetrafluorobenzyl, methoxyfenozide, and permethrin (all non-specific pyrethroid compounds) as insecticidal ingredients, the control efficacy against resistant temperate bedbugs (I) was rated "C" (mortality rate of Comparative Examples 1-3: 0%, mortality rate of Comparative Example 4: 70%, mortality rate of Comparative Example 5: 20%, mortality rate of Comparative Example 6: 0%), indicating poor control efficacy compared to Examples 1-6.

[0116] Based on the results of Comparative Examples 1 to 6, the non-specific pyrethroid compounds were rated "A" (lethality rate: 100%) for control of non-resistant temperate bedbugs, demonstrating excellent control efficacy.

[0117] Based on the results of Comparative Examples 4-6, the control efficacy of non-specific pyrethroid compounds against resistant cockroaches was rated "C" (mortality rate of Comparative Example 4: 10%, mortality rate of Comparative Example 5: 30%, mortality rate of Comparative Example 6: 15%), indicating extremely low control efficacy. However, the control efficacy against non-resistant cockroaches was rated "A" (mortality rate: 100%), demonstrating excellent control efficacy.

[0118] Generally speaking, the larger the insect, the less effective the pesticide is; conversely, the smaller the insect, the more effective the pesticide is. Considering this, in Comparative Examples 4-6, it could be expected that the control effect against resistant temperate bed bugs would be greater than that against resistant cockroaches (at least this is a natural assumption). However, in reality, in Comparative Examples 4-6, the control effect against resistant temperate bed bugs received a "C" rating, which is extremely low. Furthermore, although the pesticide content in Comparative Examples 4-6 was at the same high level (10 w / v%) as in Examples 5 and 6, the control effect against resistant temperate bed bugs was inferior to that in Examples 5 and 6. Considering these results, it can be concluded that the control effect against resistant temperate bed bugs is a characteristic effect of the specific pyrethroid compound.

[0119] Reference Example 1, which uses oxadiazon, a non-pyrethroid compound, as the insecticidal ingredient, received a "B" rating (mortality rate: 83%) for its control of resistant temperate bedbugs (I), indicating that its control effect was inferior to that of Examples 1-6. While oxadiazon, generally considered effective against resistant insects, achieved a high control effect of "A" (mortality rate: 100%) against resistant cockroaches, it is evident that its control effect against resistant temperate bedbugs (I) was inferior to that of the specific pyrethroid compounds (propargyl, fenvalerate, etc.) in Examples 5 and 6.

[0120] As described above, in contact application, specific pyrethroid compounds showed higher control efficacy against resistant temperate bed bugs than non-specific pyrethroid compounds and non-pyrethroid compounds. Furthermore, specific pyrethroid compounds showed a trend of high control efficacy not only against resistant temperate bed bugs but also against non-resistant ones. Additionally, at higher concentrations of specific pyrethroid compounds, the control efficacy against non-resistant cockroaches was higher than against resistant cockroaches. In contrast, while non-specific pyrethroid compounds were confirmed to be effective against non-resistant temperate bed bugs, their efficacy against resistant ones was low. Furthermore, at higher concentrations, there was a trend of higher control efficacy against non-resistant cockroaches than against resistant ones. Based on these results, it can be understood that, in contact application, the relationship between the presence or absence of resistance and control efficacy exhibits completely different trends in temperate bed bugs and cockroaches. Furthermore, the high control efficacy against both resistant and non-resistant temperate bed bugs in contact application can be attributed to the specific pyrethroid compound.

[0121] [Experimental Example 2] Control Effect Based on Spatial Application

[0122] The efficacy of using temperate bed bug control agents for space application against resistant and non-resistant temperate bed bugs was compared. The same evaluation method was also used to evaluate the efficacy against resistant and non-resistant cockroaches.

[0123] <Examples 7-11, Comparative Examples 7-9, Reference Example 2>

[0124] According to the formulations shown in Tables 3 and 4, insecticidal ingredients and solvents were combined to obtain temperate bed bug control agents for use as liquid pesticides in Examples 7-11, Comparative Examples 7-9, and Reference Example 2. The control efficacy of the temperate bed bug control agents of Examples 7-11, Comparative Examples 7-9, and Reference Example 2, applied in a spatial manner, against resistant temperate bed bugs (resistant temperate bed bug (I), resistant temperate bed bug (II), resistant temperate bed bug (III)), non-resistant temperate bed bugs, resistant cockroaches, and non-resistant cockroaches was evaluated using the evaluation methods described below.

[0125] <Experiment on the effectiveness of pest control based on spatial application>

[0126] Use a glass petri dish with a diameter of 9cm and a height of 2cm (volume: 127.17cm). 3 =0.00012717m 3The glass culture dish was prepared with a lid that could seal it. The pesticide solution was dripped onto the bottom surface of the lid (the top surface when the lid is on) to achieve the dosage of the insecticide shown in Tables 3 and 4, and evenly spread over the entire bottom surface of the lid. Then, a given number of test insects were placed on the bottom surface of the glass culture dish, and the dish was sealed, exposing the insects to the pesticide solution (insecticide). In this case, the pesticide solution did not directly contact the insects; rather, the insecticide evaporated from the solution acted on the insects. Twenty-four hours after the introduction of the insects, the lid of the glass culture dish was opened, and the insects were collected into a plastic cup lined with filter paper. Seventy-two hours after the introduction of the insects, the number of dead insects was counted, and the mortality rate (%) was calculated. Thereafter, the control effect was evaluated according to the following criteria.

[0127] (Judgment Criteria)

[0128] A: The mortality rate is over 90%.

[0129] B: The mortality rate is above 80% but less than 90%.

[0130] C: Fatality less than 80%

[0131]

[0132]

[0133] Examples 7-11, which use specific pyrethroid compounds as insecticidal ingredients, were applied spatially and demonstrated excellent control efficacy against resistant temperate bedbugs (I)-(III), receiving an "A" rating (mortality rate: 100% or 90%) or a "B" rating (mortality rate: 85%). Based on these results, it can be concluded that Examples 7-11 are effective against all resistant temperate bedbugs. Furthermore, it was shown that the use of acetone, ethanol, and isopropanol as solvents did not hinder the control efficacy of the specific pyrethroid compounds against resistant temperate bedbugs, and they exhibited excellent control efficacy against resistant temperate bedbugs (I)-(III). Based on these results, it can be concluded that the type of solvent does not affect the control efficacy against resistant temperate bedbugs.

[0134] In Examples 7-11, the control effect on non-resistant temperate bed bugs was rated "A" (mortality rate: 100%). The specific pyrethroid compounds showed excellent control effects not only on resistant temperate bed bugs but also on non-resistant temperate bed bugs.

[0135] In Examples 7-11, the control efficacy against resistant cockroaches was rated "C" (lethality rate: 0%), and the control efficacy against non-resistant cockroaches was also rated "C" (lethality rate: 0%). The specific pyrethroid compound showed extremely low control efficacy against both resistant and non-resistant cockroaches. In Examples 1-6 above, the control efficacy against non-resistant cockroaches was excellent when the concentration of the specific pyrethroid compound was high. Considering this, it can be said that the control efficacy against non-resistant cockroaches differed between contact application and space application.

[0136] In contrast, in Comparative Examples 7-9, which contain tetrafluorobenzyl, methoxybenzylflufenoxam, and permethrin (which are non-specific pyrethroid compounds) as insecticidal ingredients, the control effect on resistant temperate bed bugs (I) was rated as "C" (mortality rate: 0%), indicating that the control effect on resistant temperate bed bugs (I) was extremely poor.

[0137] In Comparative Examples 7 and 8, the control efficacy against non-resistant temperate bed bugs was rated "A" (mortality rate: 100%). Among the non-specific pyrethroid compounds, tetrafluorobenzyl and methoxyfenozide showed excellent control efficacy against non-resistant temperate bed bugs. On the other hand, according to the results of Comparative Example 9, among the non-specific pyrethroid compounds, permethrin showed a control efficacy of "C" (mortality rate: 0%) against non-resistant temperate bed bugs, indicating extremely poor control efficacy.

[0138] In Comparative Examples 7-9, the control efficacy against resistant cockroaches was rated "C" (lethality rate: 0%), and the control efficacy against non-resistant cockroaches was also rated "C" (lethality rate: 0%), indicating that the non-specific pyrethroid compounds were extremely ineffective against non-resistant cockroaches. Therefore, if it is ineffective against non-resistant cockroaches, it will naturally be ineffective against resistant cockroaches as well. Here, as mentioned above, generally speaking, the larger the insect, the less effective the pesticide is; conversely, the smaller the insect, the more effective the pesticide is. Considering this, in Comparative Examples 7-9, it can be expected that the control efficacy against resistant temperate bedbugs will be greater than the control efficacy against resistant cockroaches (rated "C") (at least this is a natural assumption). However, contrary to expectations, in Comparative Examples 7-9, the control efficacy against resistant temperate bed bugs was rated "C," which is also a very low rating, similar to the control efficacy against resistant cockroaches ("C" rating). Furthermore, the control efficacy of Comparative Examples 7-9 against resistant temperate bed bugs was inferior to that of Examples 7-11 ("A" or "B" rating). Thus, in Comparative Examples 7-9 using non-specific pyrethroid compounds, both the control efficacy against resistant cockroaches and resistant temperate bed bugs was rated "C." However, in Examples 7-11 using specific pyrethroid compounds, the control efficacy against resistant cockroaches was rated "C," while the control efficacy against resistant temperate bed bugs was rated "A" or "B." Considering this, it can be argued that the control efficacy against resistant temperate bed bugs in spatial applications is a unique effect of specific pyrethroid compounds.

[0139] In Reference Example 2, which uses oxadiazon, a non-pyrethroid compound, as the insecticidal ingredient, the control efficacy against resistant temperate bed bugs (I) was rated "C" (mortality rate: 0%), indicating extremely poor control efficacy against resistant temperate bed bugs. Furthermore, in Reference Example 2, the control efficacy against non-resistant temperate bed bugs, resistant cockroaches, and non-resistant cockroaches was also rated "C" (mortality rate: 0%), indicating extremely poor control efficacy against these insecticides.

[0140] As described above, similarly in spatial application, specific pyrethroid compounds exhibit higher control efficacy against resistant temperate bed bugs than non-specific pyrethroid compounds and non-pyrethroid compounds. Furthermore, specific pyrethroid compounds show a trend towards high control efficacy not only against resistant temperate bed bugs but also against non-resistant temperate bed bugs. Therefore, the high control efficacy against both resistant and non-resistant temperate bed bugs, both in contact and spatial application, is a characteristic effect of specific pyrethroid compounds.

[0141] On the other hand, as mentioned above, contact application is highly effective against non-resistant cockroaches, while spatial application is less effective against them. Regarding the control of other insects, it can be said that the trend of spatial application is different from that of contact application.

[0142] Industrial availability

[0143] The temperate bed bug control agent and method of the present invention are effective in controlling drug-resistant temperate bed bugs, and are particularly suitable for use in places where drug-resistant temperate bed bugs inhabit and may lurk or appear.

Claims

1. A temperate bed bug control agent, used to control pesticide-resistant temperate bed bugs, The temperate bed bug control agent contains a specific pyrethroid compound having a vapor pressure of 6.6661 x 10 －3 Pa or more at 25°C.

2. The temperate bed bug control agent according to claim 1, wherein, The specific pyrethroid compound is propofol and / or fenvalerate.

3. The temperate bed bug control agent according to claim 1 or 2, which is used for contact control or space control.

4. The temperate bed bug control agent according to claim 1 or 2, wherein, The specific pyrethroid compound is formulated in amounts ranging from 1 w / v% to 30 w / v.

5. The temperate bedbug control agent according to claim 1 or 2, wherein, The temperate bedbug control agent is used for contact control, and its application rate is set to achieve an adhesion level of 15 mg / m² of the specific pyrethroid compound on the target surface. 2 above.

6. The temperate bed bug control agent according to claim 1 or 2, wherein, The temperate bedbug control agent is used for space control, and its application rate is set to ensure that the specific pyrethroid compound is applied at a rate of 1000 mg / m² in the target space. 3 above.

7. A method for controlling temperate bedbugs, used to control pesticide-resistant temperate bedbugs. The method for controlling temperate bed bugs includes a contact application step, in which the temperate bed bug control agent according to claim 1 or 2 is applied to the surface of the ground, wall and / or objects where resistant temperate bed bugs may lurk or appear.

8. A method for controlling temperate bedbugs, used to control pesticide-resistant temperate bedbugs. The method for controlling temperate bed bugs includes a space application step, in which the temperate bed bug control agent according to claim 1 or 2 is sprayed, evaporated, or volatilized into the space where the drug-resistant temperate bed bugs may exist.

9. The method for controlling bedbugs in temperate regions according to claim 8, wherein, The spatial application process includes a setting application process in which the temperate bed bug repellent or a carrier containing the temperate bed bug repellent is placed on the ground, walls and / or objects where the drug-resistant temperate bed bugs may lurk or appear, or in their vicinity.

Images