Optogenetic delivery devices and methods of use thereof

Abstract

A surgical catheter comprising a first end, a second end, a main tube connecting the first end to the second end, a fluid delivery tube connected with the main tube, a fiber optic cable extending from the second end through the main tube, a button located adjacent to the fluid delivery tube, and a needle hub unit in the first end, the needle hub unit having a needle extending through the needle hub unit into the main tube.

Description

Background Technology

[0001] Optogenetics is a biological research method that involves optical and genetic techniques to control events in the cells of living animal tissues. Optogenetics manipulation involves injecting a marker to identify target cells for gene therapy. A laser of a predetermined wavelength is then applied to this area to assist the absorption of gene therapy by the target cells.

[0002] Optogenetics manipulation requires a high degree of skill and precision to label target cells, deliver therapeutic agents, and apply lasers. Current methods require removing the injection device and repositioning the laser after injection to complete the procedure. Removing the injection device before laser application reduces the accuracy of the procedure due to the need for post-injection laser repositioning.

[0003] Therefore, there is a need for a device that can perform injections and laser applications without removing the injection or laser device from the treatment area during the procedure. Summary of the Invention

[0004] One embodiment of this application includes a modular plug system comprising: a plug housing including a top surface, a bottom surface and two opposing sides, a front end and an opening opposite the front end, and a cavity extending from the front end to a rear end opening; and a load bar sized to engage the cavity in the modular plug, the load bar including two extensions on an upper surface of the load bar, the extensions being sized to engage the two openings in the top surface of the plug housing when the load bar is inserted into the cavity.

[0005] One embodiment of this application includes a surgical catheter that may have a first end, a second end, a main tube connecting the first end to the second end, a fluid delivery tube connected to the main tube, an optical fiber cable extending from the second end through the main tube, a button located near the fluid delivery tube, and a needle hub unit in the first end having a needle extending through the needle hub unit into the main tube.

[0006] In another embodiment, the button is connected to a light source that transmits light through the fiber optic cable.

[0007] In another embodiment, the optical fiber cable includes an inner core and a protective film surrounding the inner core.

[0008] In another embodiment, the protective film is removed from the fiber optic cable before it is inserted into the conduit.

[0009] In another embodiment, a guide on the second end of the conduit positions the optical fiber cable within a channel in the main tube.

[0010] In another embodiment, the fiber optic cable is located at a first position that allows fluid to flow from the fluid delivery tube into the needle.

[0011] In another embodiment, the fiber optic cable is located in a second position, in which the fiber optic cable extends through the main tube and the needle, such that the end of the fiber optic cable extends beyond the end of the needle.

[0012] In another embodiment, the diameter of the fiber optic cable allows the fluid to flow around the fiber optic cable within the needle.

[0013] In another embodiment, FGNRs / plasmid fluid is injected through the fluid delivery tube.

[0014] In another embodiment, the needle is sized to accommodate the optical fiber cable without the protective film.

[0015] In another embodiment, the fiber optic cable is sealed within a metal tube that slides along a seal of the injection device, allowing the fiber optic cable to move through the needle. Therefore, the seal is not on the fiber optic cable but on the metal tube.

[0016] Another embodiment of this application includes a method for gene therapy using a surgical catheter, comprising the steps of: inserting an optical fiber cable via a second opening into a main tube connecting a first opening and a second opening in the catheter; injecting fluid into a patient via a fluid delivery tube connected to the main tube and a needle connected to the first opening via a needle hub unit; positioning the optical fiber cable in the needle after the fluid is injected; and pressing a button located near the fluid delivery tube to transmit light through the optical fiber cable.

[0017] Another embodiment includes the step of pressing the button to activate a light source that transmits light through the fiber optic cable.

[0018] In another embodiment, the optical fiber cable includes an inner core and a protective film surrounding the inner core.

[0019] Another embodiment includes the step of removing the protective film from the optical fiber cable before inserting the optical fiber cable into the conduit.

[0020] Another embodiment includes the step of guiding the fiber optic cable into the main pipe via a guide at the second end of the conduit.

[0021] Another embodiment includes the step of positioning the fiber optic cable at a first position that allows the fluid to flow from the fluid delivery tube into the needle.

[0022] Another embodiment includes the step of positioning the optical fiber cable in a second position, in which the optical fiber cable extends through the main tube and the needle, such that the end of the optical fiber cable extends beyond the end of the needle.

[0023] In another embodiment, the diameter of the fiber optic cable allows the fluid to flow around the fiber optic cable within the needle.

[0024] In another embodiment, FGNRs / plasmid fluid is injected through the fluid delivery tube.

[0025] In another embodiment, the needle is sized to accommodate the optical fiber cable without the protective film.

[0026] Another embodiment may include the step of: waiting a predetermined time before transmitting the light to the injection site, wherein the predetermined time is sufficient for the fluid to be distributed in the patient's body before the light is transmitted. Attached Figure Description

[0027] The invention and its many accompanying advantages can be more fully understood by referring to the following detailed description taken in conjunction with the accompanying drawings, in which: Figure 1 A perspective view of a catheter used to inject fluid during surgical procedures is shown. Figure 2 A cross-sectional side view of the duct is shown; Figure 3 An unfolded view of the needle hub unit that engages with the opening in the first end of the catheter is shown; Figure 4 An unfolded diagram of the needle hub unit is shown; Figure 5 The first position of the fiber optic cable core in the conduit is shown; Figure 6 The second position of the fiber optic cable core within the conduit is shown; and Figure 7 A schematic diagram of the method using a surgical catheter is shown. Detailed Implementation

[0028] The specific embodiments described below are intended to illustrate various configurations of the present technology and are not intended to represent the only configuration in which the present technology can be practiced. The accompanying drawings are incorporated herein and form part of the specific embodiments. The specific embodiments include particular details to provide a thorough understanding of the present technology. However, the present technology is not limited to the specific details set forth herein and can be practiced using one or more implementations. In one or more cases, structures and components are shown in simplified form to avoid obscuring the concept of the present technology.

[0029] In the accompanying drawings referenced herein, reference numerals denote the same or corresponding portions throughout several views or embodiments.

[0030] Figure 1 A perspective view of a catheter 100 for injecting fluid during a medical procedure is shown. The catheter 100 includes a first end 102, a second end 104, a main tube 106 connecting the first end 102 to the second end 104, a fluid delivery tube 108 connected to the main tube 106, an optical fiber cable 110 extending from the second end 104 through the main tube 106, and a button 112 located near the fluid delivery tube 108. A needle hub unit 114 is inserted into the first end 102, and a needle 116 extends through the needle hub unit 114 into the main tube 106. The catheter 100 may be made of any material suitable for surgical instruments, including but not limited to plastics, polyvinyl chloride, silicone rubber, polyurethane, polyethylene, terephthalate, latex, and thermoplastic elastomers.

[0031] The catheter 100 allows fluid to be injected from the fluid delivery tube 108 through the main tube 106, needle hub unit 114, and needle 116 into an area on the patient's body. After injection, the fiber optic cable 110 is moved so that its end extends through the needle 116 to deliver light to the injection area. When button 112 is pressed, light is emitted through the fiber optic cable 116 to the injection area without removing the surgical catheter 100 from the injection area or the fiber optic cable 110 from the surgical catheter 100. Because the surgical catheter 100 remains in the area where the patient is receiving fluid, the light emitted from the fiber optic cable 110 is focused on the exact area of ​​injection, thereby improving the effectiveness of phototherapy.

[0032] Figure 2 A cross-sectional side view of the conduit 100 is shown. An optical fiber cable 110 enters a channel 202 in a main tube 106 via an opening 204. The optical fiber cable 110 consists of an inner core 206 made of a transparent material (such as glass) and an outer coating made of a solid material (such as plastic or rubber). The opening 204 is sized to accommodate the inner core 206 of the optical fiber cable 110, with the outer portion of the opening 204 angled toward the channel 202 to form a guide 208 to guide the optical fiber cable into the channel 202. In one embodiment, the channel 202 comprises a material forming a fluid seal with the inner core 206 of the optical fiber cable 110. The channel 202 extends from a second end 104 of the conduit 100 to a first end 102. A needle seat unit 114 engages an opening 210 in the first end 102 of the conduit 100. In one embodiment, the needle seat unit 114 has a threaded end that engages with the threaded inner wall of the opening 210. The needle seat unit 114 is located in the opening 210 such that a needle channel 212 is concentric with the channel 202. The needle channel 212 extends through the needle base unit 114 and the needle 116, so that the inner core 206 of the fiber optic cable 110 extends beyond the end of the needle 116.

[0033] The fluid delivery tube 108 is positioned at an angle θ to the top surface of the main tube 106. In one embodiment, angle θ is forty-five degrees. In another embodiment, angle θ is less than forty-five degrees. In yet another embodiment, angle θ is greater than forty-five degrees and less than ninety degrees. The fluid delivery tube 108 is secured to the main tube 106 by a support unit 214, which connects to the lower surface of the fluid delivery tube 108 and the top surface of the main tube 106. In one embodiment, the edge of the support unit 214 furthest from the needle 116 is concave to accommodate the shape of a user's finger. In another embodiment, a button 112 is located on the support unit 214, allowing the user of the catheter to press the button while using the catheter. A tube channel 216 extends along the entire length of the fluid delivery tube 108 through its center. The tube channel 216 extends into a channel 202, allowing fluid to be delivered through the tube channel 216 and into the main tube 202 for insertion through the needle 116. The injection unit 218 is located at the end of the fluid delivery tube 108 to allow the syringe to inject fluid into the channel 202 for delivery by the needle 116.

[0034] In one embodiment, the inner core 206 of the fiber optic cable 110 engages with a tube 220 located in a channel 202. The tube 220 is sized to allow free movement within the channel 202. The inner core 206 of the fiber optic cable 110 engages with the inner channel of the tube 220 such that the inner core 206 of the fiber optic cable 110 and the inner channel of the tube 220 form a liquid-tight seal, preventing liquid injected into the channel from flowing through the inner channel of the tube 220. In one embodiment, the tube 220 is made of metal. In another embodiment, the inner channel of the tube 220 includes a compression material that engages with the inner core 206 of the fiber optic cable 110. In yet another embodiment, the inner core 206 of the fiber optic cable 110 engages with the inner channel of the tube 220 such that the inner core 206 extends to the end of the needle 116 in a first position and is positioned within the channel 202 without extending into the needle in a second position. The position of the tube 220 is controlled by a user by moving the fiber optic cable 110 into and out of the channel 202. In another embodiment, the tube 220 forms a seal with the channel 202 to prevent fluid from moving around the tube 220 in the channel 202.

[0035] Figure 3A developed view of the needle seat unit 114 engaging an opening 210 in the first end 102 of the conduit 100 is shown. The inner core 206 of the fiber optic cable 110 passes through the channel 202 and enters the needle channel 212. In one embodiment, the needle channel 212 is formed by an inner opening of a needle 116, sized to accommodate the inner core 206 of the fiber optic cable 110. By allowing the inner core 206 of the fiber optic cable 110 to pass through the needle, the inner core 206 is supported by the needle. Furthermore, the needle 116 prevents light from scattering from the inner core 206, thereby reducing the effectiveness of the fiber optic cable 210. The needle seat unit 114 includes a flange 302 extending around the periphery of the portion of the needle seat unit 114 that engages with the opening 210. The opening 210 includes a thread 304 on its inner surface, which engages with the flange 302 to secure the needle seat unit 114 within the opening 210.

[0036] Figure 4 A developed view of the needle hub unit 114 is shown. The inner core 206 of the fiber optic cable 110 extends through the needle hub unit 114 and the needle 116, such that the end 402 of the inner core 206 extends beyond the end of the needle 116. In one embodiment, the end 402 of the inner core 206 is dome-shaped to control light scattering in the treatment area. The inner core 206 is located within the channel 202, the needle hub unit 114, and the needle 116, allowing it to move within the channel 202 toward and away from the needle 116. By moving the inner core 206 to different positions within the channel 202, the operator of the catheter 100 can inject fluid while delivering light to the injection area without removing the catheter 100.

[0037] Figure 5 The inner core 206 of the fiber optic cable 110 is shown in a first position within the catheter 100. When the inner core 206 is in the first position within the channel 202, fluid can be delivered through the fluid delivery tube 108 and the channel 202 to the needle hub unit 114 and the needle 116. In one embodiment, the user of the catheter 100 moves the inner core 206 of the fiber optic cable 110 to the first position within the channel. The user injects fluid into the fluid delivery tube 108 with a force sufficient to push fluid into the channel 202 and through the needle hub unit 114 and the needle 116. The fluid flows out from the needle 116 and into the patient's body at the site of treatment. In one embodiment, the fluid injected into the patient is an FGNRs / plasmid fluid. In one embodiment, the diameter of the inner core 206 of the fiber optic cable 110 is designed to allow fluid to flow around the inner core 206 and through the needle hub unit 114 and the needle 116.

[0038] Figure 6The inner core 206 of the fiber optic cable 110 is shown in a second position within the conduit 100. In this second position, the inner core 206 of the fiber optic cable 110 extends through the channel 202 into the needle hub unit 114 and through the needle 116. An end 402 of the inner core 206 extends beyond the end of the needle 216 to allow light to be applied to the area previously injected with fluid. In one embodiment, the wavelength of the light transmitted through the inner core 206 is 620-750 nm. In one embodiment, a mechanical stop is provided within the channel 202 to limit movement of the fiber optic cable 110 between the first and second positions.

[0039] Figure 7 A schematic diagram of a method using a surgical catheter 100 is shown. In step 702, an optical fiber cable 110 is inserted into a channel 202 in the catheter 100. The optical fiber cable 110 includes a core surrounded by an insulating layer. In one embodiment, a guide in the opening into which the optical fiber cable 110 is inserted guides the optical fiber cable 110 into the channel 202 in the catheter 100. In step 704, the optical fiber cable 110 is positioned at a first location in the channel 202. The first location allows fluid to flow from a fluid delivery tube through the channel 202 and into a needle 116 for injection into the patient. In step 706, the needle 116 is positioned above the injection site. In step 708, fluid is injected with sufficient force into the fluid delivery tube 108 to push the fluid through the fluid delivery tube 108 into the main channel 202 and through the needle 116. In step 710, fluid is injected into the treatment area using the force generated by injecting fluid into the fluid delivery tube 108.

[0040] In step 712, the fiber optic cable 110 is moved to a second position. In one embodiment, the second position is where the end of the fiber optic cable 110 extends beyond the end of the needle 116. In another embodiment, the second position is where the fiber optic cable 110 is located inside the needle, but allows light to be transmitted from the open end of the needle 116 to the treatment area. In step 714, button 112 on the catheter is pressed, and light is emitted from the fiber optic cable 110 to the treatment area. In another embodiment, moving the fiber optic cable 110 to the second position forces any residual fluid in the needle 116 to drain from the needle 116 and into the injection area. In one embodiment, light is transmitted through the fiber optic cable 110 while injecting fluid into the injection area, allowing the FGNR to help the fluid cross the tissue barrier.

[0041] In one embodiment, the process of moving the fiber optic cable 110 is automated, causing the fiber optic cable 110 to move in a predetermined manner to a first position and a second position. In another embodiment, the transmission of light is automated, turning the light on and off within a predetermined time after injection into the patient. In yet another embodiment, the predetermined time is based on the type of material in the fluid, the length and type of the FGNRs, the amount of light required to enhance the injection, the time required for the fluid to disperse within the patient, and the effect of the light on the patient after injection. In yet another embodiment, the automation of the injection prevents prolonged exposure to light to avoid negative effects on the injection and burns to the injection site.

[0042] In addition to the embodiments disclosed herein, various embodiments of the invention are contemplated. The above embodiments should be considered as examples of the invention and not as limiting its scope. A review of the detailed description and drawings will reveal other embodiments of the invention beyond those described above. Therefore, many combinations, arrangements, variations, and modifications of the above embodiments of the invention not explicitly set forth herein will still fall within the scope of the invention.

[0043] In one embodiment, a catheter, including a surgical catheter, includes: a first end; a second end; a main tube connecting the first end to the second end; a fluid delivery tube connected to the main tube; an optical fiber cable extending from the second end through the main tube; a button located near the fluid delivery tube; and a needle hub unit in the first end having a needle extending through the needle hub unit into the main tube. In one embodiment, the catheter, including the surgical catheter, has an optical fiber that is multi-lumen.

[0044] In one embodiment, the invention includes a surgical catheter in which the fiber optic cable is hollow and the needle can retract through a hollow opening in the fiber optic cable. In another embodiment, the surgical catheter includes a lumen for injecting a therapeutic agent, wherein the catheter body is a light-guiding fiber optic cable. In one embodiment, the therapeutic agent is a protein, peptide, nucleic acid, or small molecule. In another embodiment, the therapeutic agent is a genetic element (AAV, lentivirus, or other nucleic acid) for gene therapy. In yet another embodiment, the therapeutic agent is an analgesic, including NSAIDs, opioids, aspirin, or other analgesics.

[0045] In one embodiment, the catheter, including a surgical catheter, has a reflective coating on its outer surface to limit transmitted light. In another embodiment, the catheter, including a surgical catheter, includes a reflective coating coated with a biocompatible membrane. In yet another embodiment, the catheter, including a surgical catheter, includes a reflective coating on its outer surface to limit transmitted light.

[0046] Figure 3A developed view of the needle hub unit 114 engaging an opening 210 in the first end 102 of the conduit 100 is shown. The inner core 206 of the fiber optic cable 110 passes through the channel 202 and enters the needle channel 212. In one embodiment, the needle channel 212 is formed by an inner opening of a needle 116, sized to accommodate the inner core 206 of the fiber optic cable 110. By allowing the inner core 206 of the fiber optic cable 110 to pass through the needle, the inner core 206 is supported by the needle. Furthermore, the needle 116 prevents light from scattering from the inner core 206, thereby reducing the effectiveness of the fiber optic cable 210. The needle hub unit 114 includes a flange 302 extending around the periphery of a portion of the needle hub unit 114 engaging the opening 210. The opening 210 includes threads 304 on its inner surface that engage the flange 302 to secure the needle hub unit 114 within the opening 210.

[0047] Figure 4 An unfolded view of the needle hub unit 114 is shown. The inner core 206 of the fiber optic cable 110 passes through the needle hub unit 114 and the needle 116, such that the end 402 of the inner core 206 extends beyond the end of the needle 116. In one embodiment, the end 402 of the inner core 206 is dome-shaped to control light scattering in the treatment area. The inner core 206 is positioned within the channel 202, the needle hub unit 114, and the needle 116, allowing it to move within the channel 202 toward and away from the needle 116. By moving the inner core 206 to different positions within the channel 202, the operator of the catheter 100 can inject fluid while delivering light to the injection area without removing the catheter 100.

[0048] Figure 5 The diagram shows the inner core 206 of the fiber optic cable 110 in a first position within the conduit 100. When the inner core 206 is in the first position within the channel 202, fluid can be delivered through the fluid delivery tube 108 and the channel 202 to the needle hub unit 114 and the needle 116. In one embodiment, the user of the conduit 100 moves the inner core 206 of the fiber optic cable 110 to the first position within the channel. The user injects fluid into the fluid delivery tube 108 with sufficient force to push the fluid into the channel 202 and through the needle hub unit 114 and the needle 116. The fluid flows out from the needle 116 and into the patient's body at the site of treatment. In one embodiment, the fluid injected into the patient is an FGNRs / plasmid fluid. In one embodiment, the diameter of the inner core 206 of the fiber optic cable 110 is designed to allow fluid to flow around the inner core 206 and through the needle hub unit 114 and the needle 116.

[0049] Figure 6The diagram shows a second position of the inner core 206 of the fiber optic cable 110 within the conduit 100. In this second position, the inner core 206 of the fiber optic cable 110 passes through the channel 202 into the needle holder unit 114 and through the needle 116. The end 402 of the inner core 206 extends beyond the end of the needle 216 to allow light to be applied to the area previously injected with fluid. In one embodiment, the wavelength of the light transmitted through the inner core 206 is 620-750 nm. In one embodiment, a mechanical stop is provided within the channel 202 to limit movement of the fiber optic cable 110 between the first and second positions.

[0050] Figure 7 A schematic diagram of a method using a surgical catheter 100 is shown. In step 702, an optical fiber cable 110 is inserted into a channel 202 in the catheter 100. The optical fiber cable 110 includes a core surrounded by an insulating layer. In one embodiment, a guide inserted into an opening of the optical fiber cable 110 guides the optical fiber cable 110 into the channel 202 in the catheter 100. In step 704, the optical fiber cable 110 is positioned at a first location in the channel 202. The first location allows fluid to flow from a fluid delivery tube through the channel 202 and into a needle 116 for injection into the patient. In step 706, the needle 116 is positioned above the injection site. In step 708, fluid is injected with sufficient force into the fluid delivery tube 108 to push the fluid through the fluid delivery tube 108 into the main conduit 202 and through the needle 116. In step 710, fluid is injected into the treatment area using the force generated by injecting fluid into the fluid delivery tube 108.

[0051] In step 712, the fiber optic cable 110 is moved to a second position. In one embodiment, the second position is where the end of the fiber optic cable extends beyond the end of the needle 116. In another embodiment, the second position is where the fiber optic cable 110 is located inside the needle, but allows light to be transmitted from the open end of the needle 116 to the treatment area. In step 714, button 112 on the catheter is pressed, and light is emitted from the fiber optic cable 110 to the treatment area. In another embodiment, moving the fiber optic cable 110 to the second position forces any residual fluid in the needle 116 to drain from the needle 116 and into the injection area. In one embodiment, light is transmitted through the fiber optic cable 110 while fluid is injected into the injection area, allowing FGNRs to assist the fluid in crossing the tissue barrier.

[0052] In one embodiment, the process of moving the fiber optic cable 110 is automated, causing the fiber optic cable 110 to move in a predetermined manner to a first position and a second position. In another embodiment, the transmission of light is automated to turn the light on and off for a predetermined amount of time after injection into the patient. In another embodiment, the predetermined time is based on the type of material in the fluid, the length and type of the FGNRs, the amount of light required to enhance the injection, the time required for the fluid to disperse within the patient, and the effect of the light on the patient after injection. In yet another embodiment, the automation of the injection prevents prolonged exposure to light to avoid negative effects on the injection and burns to the injection site.

[0053] In addition to the embodiments disclosed herein, various embodiments of the invention are contemplated. The above embodiments should be considered as examples of the invention and not as limiting its scope. A review of the detailed description and drawings will reveal other embodiments of the invention beyond the above embodiments. Therefore, many combinations, arrangements, variations, and modifications of the above embodiments of the invention not explicitly set forth herein will still fall within the scope of the invention.

[0054] In one embodiment, a catheter, including a surgical catheter, includes: a first end; a second end; a main tube connecting the first end and the second end; a fluid delivery tube connected to the main tube; an optical fiber cable extending from the second end through the main tube; a button located near the fluid delivery tube; and a needle hub unit in the first end having a needle extending through the needle hub unit into the main tube. In one embodiment, the catheter, including the surgical catheter, has an optical fiber that is multi-lumen.

[0055] In one embodiment, the invention includes a surgical catheter in which the fiber optic cable is hollow and the needle can retract through a hollow opening in the fiber optic cable. In another embodiment, a surgical catheter includes a lumen for injecting a therapeutic agent, wherein the catheter body is a light-guiding fiber optic cable. In one embodiment, the therapeutic agent is a protein, peptide, nucleic acid, or small molecule. In another embodiment, the therapeutic agent is a genetic element (AAV, lentivirus, or other nucleic acid) for gene therapy. In yet another embodiment, the therapeutic agent is an analgesic, including NSAIDs, opioids, aspirin, or other analgesics.

[0056] In one embodiment, the catheter, including a surgical catheter, has a reflective coating on its outer surface to limit transmitted light. In another embodiment, the catheter, including a surgical catheter, includes a reflective coating coated with a biocompatible membrane. In yet another embodiment, the catheter, including a surgical catheter, includes a reflective coating on its outer surface to limit transmitted light.

Claims

1. A surgical catheter, characterized in that, include: First end; The second end; The main connector that connects the first end to the second end; A fluid delivery pipe connected to the main pipe; An optical fiber cable extends from the second end through the main tube; The button is located near the fluid delivery pipe; as well as The needle hub unit in the first end has a needle extending through the needle hub unit into the tube.

2. The surgical catheter according to claim 1, characterized in that, The button is connected to a light source that transmits light through the fiber optic cable.

3. The surgical catheter according to claim 1, characterized in that, The optical fiber cable includes an inner core and a protective film surrounding the inner core.

4. The surgical catheter according to claim 3, characterized in that, The protective film is removed from the fiber optic cable before it is inserted into the conduit.

5. The surgical catheter according to claim 1, characterized in that, The guide on the second end of the conduit positions the optical fiber cable within a channel in the main tube.

6. The surgical catheter according to claim 1, characterized in that, The fiber optic cable is located at a first position that allows fluid to flow from the fluid delivery tube into the needle.

7. The surgical catheter according to claim 6, characterized in that, The fiber optic cable is located in a second position, in which the fiber optic cable extends through the main tube and the needle, such that the end of the fiber optic cable extends beyond the end of the needle.

8. The surgical catheter according to claim 6, characterized in that, The diameter of the fiber optic cable allows the fluid to flow around the fiber optic cable in the needle.

9. The surgical catheter according to claim 1, characterized in that, FGNRs / plasmid fluid is injected through the fluid delivery tube.

10. The surgical catheter according to claim 1, characterized in that, Any FGNRs and pharmaceutical products can be injected through the fluid delivery tube.

11. The surgical catheter according to claim 1, characterized in that, The wavelength of the light corresponds to the length of the FGNRs to achieve maximum efficiency.

12. The surgical catheter according to claim 4, characterized in that, The needle is sized to accommodate the optical fiber cable without the protective film.

13. A method for gene therapy using a surgical catheter, characterized in that, Includes the following steps: The fiber optic cable is inserted through the second opening into the main pipe connecting the first opening and the second opening in the conduit; Fluid is injected into the patient through the tube via a fluid delivery tube connected to the tube and a needle connected to the first opening via a needle hub unit; After the fluid is injected, the optical fiber cable is positioned in the needle; as well as Press the button located near the fluid delivery tube to transmit light through the fiber optic cable.

14. The method according to claim 13, characterized in that, The steps include: pressing the button to activate the light source that transmits light through the fiber optic cable.

15. The method according to claim 13, characterized in that, The optical fiber cable includes an inner core and a protective film surrounding the inner core.

16. The method according to claim 15, characterized in that, The procedure includes removing the protective film from the optical fiber cable before inserting it into the conduit.

17. The method according to claim 13, characterized in that, The procedure includes the step of guiding the optical fiber cable into the main tube through a guide on the second end of the conduit.

18. The method according to claim 13, characterized in that, The step includes: positioning the fiber optic cable at a first position that allows the fluid to flow from the fluid delivery tube into the needle.

19. The method according to claim 18, characterized in that, The method includes the following steps: positioning the optical fiber cable in a second position, in which the optical fiber cable extends through the main tube and the needle, such that the end of the optical fiber cable extends beyond the end of the needle.

20. The method according to claim 18, characterized in that, The diameter of the fiber optic cable allows the fluid to flow around the fiber optic cable in the needle.

21. The method according to claim 13, characterized in that, FGNRs / plasmid fluid is injected through the fluid delivery tube.

22. The method according to claim 16, characterized in that, The needle is sized to accommodate the optical fiber cable without the protective film.

23. The method according to claim 13, characterized in that, The injection of the fluid is automated.

24. The method according to claim 13, characterized in that, The procedure includes: waiting a predetermined time before transmitting the light to the injection site, wherein the predetermined time is sufficient for the fluid to be distributed in the patient's body before the light is transmitted.

25. The method according to claim 13, characterized in that, The laser is activated while the fluid is being injected, allowing the FGNRs to assist the fluid in crossing the tissue barrier.

26. The surgical catheter according to claim 1, characterized in that, The optical fiber is hollow, and the needle can be retracted.

27. The surgical catheter according to claim 1, characterized in that, The catheter lumen is used for gene therapy injection, and the main body of the catheter is optical fiber.

28. The surgical catheter according to claim 26, characterized in that, The conduit has a reflective coating on its outer surface to limit the transmitted light.

29. The surgical catheter according to claim 26, characterized in that, The reflective coating of the catheter is coated with a biocompatible membrane.

30. The surgical catheter according to claim 1, characterized in that, The optical fiber is multi-cavity.

31. The surgical catheter according to claim 26, characterized in that, The catheter is multi-lumen.

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