A medicine-food homologous composition with the functions of benefiting qi and tonifying blood and a preparation method thereof

Abstract

The present application relates to the technical field of functional food, in particular to a medicine-food homologous composition with the functions of tonifying qi and nourishing blood and a preparation method thereof.The composition comprises clouded angelica, soybean, jujube, astragalus root and longan aril.The composition provided by the present application is a medicine-food homologous substance, has a mild effect and high safety.Meanwhile, the present prescription has the effects of tonifying heart and spleen, tonifying qi and nourishing blood, has a good conditioning effect on people with weak spleen and stomach and qi-blood deficiency, and can relieve symptoms such as body fatigue, dizziness, palpitation, shortness of breath, spontaneous sweating and lack of spirit caused by weak spleen and stomach and qi-blood deficiency.

Description

Technical Field

[0001] This invention relates to the field of functional food technology, and in particular to a medicinal and edible composition that invigorates qi and nourishes blood, and its preparation method. Background Technology

[0002] Qi and blood deficiency is caused by factors such as irregular diet, overwork, insufficient sleep, emotional depression, and physiological blood loss, leading to symptoms such as fatigue, dizziness, palpitations, shortness of breath, spontaneous sweating, and lethargy. Some people may also experience symptoms such as sallow complexion, pale lips and nails, insomnia, and excessive dreaming. It is especially common in people with congenitally weak constitutions, postpartum women, middle-aged and elderly people, and those who work under high-intensity conditions for extended periods. Prolonged qi and blood deficiency not only affects normal work, life, and study, and reduces the body's resistance, but may also further induce menstrual irregularities, limb numbness, and decreased organ function, accelerating aging and posing a potential threat to health. Furthermore, qi and blood are closely related to spleen and stomach function and the harmony between the heart and spleen. People with qi and blood deficiency often have weak spleen and stomach, and insufficient heart and spleen function. The spleen is the source of qi and blood production; if the spleen and stomach malfunction, qi and blood production will be insufficient, and if the heart and spleen are imbalanced, qi and blood cannot properly nourish the body, leading to qi and blood deficiency.

[0003] Traditional Chinese medicine (TCM) believes that Qi and blood are fundamental to maintaining human life. "Qi is the commander of blood, and blood is the mother of Qi." Healthy Qi and blood depend on "harmony between the heart and spleen, abundant Qi and blood, and normal metabolism." When the spleen and stomach are weak, or the heart and spleen are deficient, the generation and circulation of Qi and blood are impaired, leading to a lack of nourishment and symptoms such as fatigue, dizziness, palpitations, shortness of breath, and spontaneous sweating. The TCM concept of "tonifying the heart and spleen, replenishing Qi and blood, and strengthening the spleen's digestive function" is the main approach to improving Qi and blood deficiency. By regulating spleen and stomach function, nourishing the heart and spleen, and replenishing Qi and blood, the symptoms of Qi and blood deficiency can be alleviated at their root. Summary of the Invention

[0004] To address the aforementioned problems, this invention provides a medicinal and edible homologous composition with qi-tonifying and blood-nourishing properties, along with its preparation method. The composition provided by this invention consists entirely of medicinal and edible homologous substances, exhibiting mild effects and no toxic side effects. Furthermore, this formula tonifies the heart and spleen, and nourishes qi and blood. It has a good conditioning effect on individuals with weak spleen and stomach, and qi and blood deficiency, and can alleviate symptoms such as fatigue, dizziness, palpitations, shortness of breath, spontaneous sweating, and lethargy caused by weak spleen and stomach and qi and blood deficiency.

[0005] To achieve the above objectives, the present invention provides the following technical solution: This invention provides a food-medicine composition that invigorates qi and nourishes blood, including Angelica sinensis, soybean, jujube, Astragalus membranaceus, and longan pulp.

[0006] Preferably, the amounts of each ingredient in the composition are: 3g of Angelica sinensis, 60g of soybeans, 57g of jujubes, 18g of Astragalus membranaceus, and 54g of longan pulp.

[0007] The present invention also provides a method for preparing the composition described in the above technical solution, comprising the following steps: 1) Soak the Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp in water to obtain a soaking material; 2) Boil the soaking material obtained in step 1), and dry the resulting decoction to obtain the composition.

[0008] Preferably, in step 1), the total mass ratio of Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp to water is 1:10.

[0009] Preferably, the soaking time in step 1) is 2 hours.

[0010] Preferably, the conditions for decocting in step 2) include: decocting twice, for 30 minutes each time.

[0011] Preferably, the drying conditions in step 2) include: combining the decoctions obtained from two decoctions and filtering them, concentrating the filtrate to obtain an extract, and drying the extract at 60°C to a constant weight to obtain the composition.

[0012] The present invention also provides the application of the composition described in the above technical solution in the preparation of qi-tonifying and blood-nourishing products.

[0013] The present invention also provides a composition that invigorates qi and nourishes blood, comprising the composition described above and food-acceptable excipients.

[0014] Preferably, the dosage form of the composition includes decoction, granules, pills or capsules.

[0015] The principal ingredients are longan pulp and jujube. Longan pulp is sweet and warm, entering the heart and spleen meridians, specifically nourishing heart blood and calming the mind. The *Compendium of Materia Medica* states that it is "an essential medicine for the heart and spleen." For those suffering from palpitations, forgetfulness, insomnia, and excessive dreaming due to excessive thinking or overwork damaging the heart and spleen, nothing else can remedy this. Jujube is sweet and warm, entering the spleen and stomach meridians, tonifying the middle energizer, replenishing qi, nourishing blood, and calming the mind. The *Compendium of Materia Medica* calls jujube "the fruit of the spleen." The heavy use of jujube aims to strongly tonify the qi of the spleen and stomach, thus providing the source for the generation of qi and blood. The two ingredients complement each other, tonifying both the heart and spleen, regulating qi and blood, and jointly achieving the effects of tonifying the heart and spleen, nourishing blood, and calming the mind.

[0016] Assistant herb: Astragalus. Astragalus is sweet and slightly warm, serving as an assistant herb. Its purpose is twofold: to replenish qi and generate blood. Astragalus is the commander of qi and the mother of blood. When using large doses of longan and jujube to replenish blood, it is essential to supplement with qi-tonifying herbs, ensuring that abundant qi leads to blood generation, and sufficient blood provides a foundation for qi. Astragalus replenishes the qi of the spleen and lungs, assisting the principal herb in transforming the essence of food and water into new blood; it also raises the clear yang qi, allowing the essence of food and water to ascend to the heart and lungs, nourishing the head and eyes, and relieving symptoms such as dizziness, fatigue, and weakness. When combined with longan and jujube, astragalus replenishes both qi and blood, achieving a synergistic effect.

[0017] Assistant herb: Angelica sinensis. Angelica sinensis is sweet, pungent, and warm in nature, serving as both an assistant and guiding herb. The *Compendium of Materia Medica* records Angelica sinensis as a "holy medicine for blood," capable of guiding other herbs into the blood, making the overall blood-tonifying effect of the formula more focused. Angelica sinensis can invigorate blood and remove stagnation; large doses of tonifying herbs can easily cause congestion, but its pungent and warm nature allows for dispersion, ensuring that tonification is not stagnant, achieving a balance of stillness and movement. Combined with Astragalus membranaceus, it subtly aligns with the concept of "Angelica sinensis blood-tonifying decoction." Angelica sinensis's pungent and warm nature harmonizes the other herbs, ensuring that the entire formula is tonifying without being cloying, and warming without being drying.

[0018] Guiding herb: Angelica sinensis (also used). Angelica sinensis, with its pungent and warm properties, can guide other herbs through the twelve meridians, especially directing them into the blood level of the heart and liver. Furthermore, the combination of Angelica sinensis and Astragalus membranaceus, one promoting qi and the other blood, one ascending and the other dispersing, ensures that the entire formula nourishes without stagnation and moves without dispersion.

[0019] Beneficial effects: The compositions provided by this invention are all food-grade medicinal materials, with mild effects and no toxic side effects. Furthermore, this formula has the effects of tonifying the heart and spleen, replenishing qi and nourishing blood. It has a good conditioning effect on people with weak spleen and stomach, and deficiency of qi and blood, and can relieve symptoms such as fatigue, dizziness, palpitations, shortness of breath, spontaneous sweating, and lethargy caused by weak spleen and stomach, and deficiency of qi and blood. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings used in the embodiments will be briefly described below.

[0021] Figure 1 Analysis of the results of the running exhaustion test in mice and the effects of the composition on anal temperature, food intake, and water intake in mice with qi and blood deficiency; *P<0.05, **P<0.01, compared with the control group; #P<0.05, ##P<0.01, compared with the model group.

[0022] Figure 2 The effect of the composition on the immune organs of mice with qi and blood deficiency was as follows: *P<0.05, **P<0.01, compared with the control group; #P<0.05, ##P<0.01, compared with the model group.

[0023] Figure 3The effect of the composition on the number of red blood cells and hemoglobin content in mice with qi and blood deficiency; *P<0.05, **P<0.01, compared with the control group; #P<0.05, ##P<0.01, compared with the model group. Detailed Implementation

[0024] This invention provides a composition for invigorating qi and nourishing blood, comprising Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp. In this invention, the dosage of each ingredient in the composition is 3g of Angelica sinensis, 60g of soybeans, 57g of jujubes, 18g of Astragalus membranaceus, and 54g of longan pulp. This invention does not have any special limitations on the source of the above ingredients; commercially available ingredients are acceptable.

[0025] The present invention also provides a method for preparing the composition described in the above technical solution, comprising the following steps: 1) Soak the Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp in water to obtain a soaking material; 2) Boil the soaking material obtained in step 1), and dry the resulting decoction to obtain the composition.

[0026] This invention involves soaking a mixture of Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp in water to obtain a soaking solution. In this invention, the preferred mass ratio of the total mass of the Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp to the mass of water is 1:10. The preferred soaking time in this invention is 2 hours.

[0027] This invention involves decocting the obtained soaking material, drying the resulting decoction, and obtaining a composition. Preferably, the decoction conditions include: decocting twice, 30 minutes each time. Preferably, the drying conditions include: combining the decoctions obtained from the two decoctions, filtering, concentrating the filtrate to obtain an extract, and drying the extract at 60°C to constant weight to obtain the composition.

[0028] The present invention also provides the application of the composition described above in the preparation of products that invigorate qi and nourish blood.

[0029] This invention also provides a composition that invigorates qi and nourishes blood, comprising the composition described above and food-grade excipients. In this invention, the dosage form of the composition preferably includes decoctions, granules, pills, or capsules. This invention does not impose any particular limitation on the preparation method of the above-mentioned decoctions, granules, pills, or capsules; conventional preparation methods are acceptable.

[0030] To further illustrate the present invention, the following detailed description is provided in conjunction with embodiments, but these should not be construed as limiting the scope of protection of the present invention.

[0031] Example A medicinal and edible composition with qi-tonifying and blood-nourishing properties and its preparation method comprises the following steps: 1) Mix the total mass of 3g of Angelica sinensis, 60g of soybeans, 57g of jujubes, 18g of Astragalus membranaceus, and 54g of longan pulp with water at a mass ratio of 1:10 and soak for 2 hours to obtain the soaking material; 2) The soaking material obtained in step 1) is decocted, and the resulting decoction is dried to obtain the composition; wherein, the decoction is decocted twice, each time for 30 minutes; the decoctions obtained from the two decoctions are combined and filtered, and the filtrate is concentrated by a rotary evaporator to obtain an extract. The extract is placed in a 60°C oven and dried to constant weight to obtain the composition.

[0032] Functional verification test The powdered composition prepared in the examples was mixed with purified water to prepare a solution with a concentration of 160 mg / mL.

[0033] After 3 days of acclimatization, SPF-grade Kunming mice were randomly divided into three groups of six mice each: a control group, a model group, and a drug group. Except for the control group, all mice underwent a running fatigue test from day 1 to day 7, with an electrical stimulation intensity of 4.5 mA, until the mice could no longer run on the track. On days 2 and 4, the two groups of mice were subcutaneously injected with acetylphenylhydrazine at doses of 20 and 40 mg / kg, respectively. From day 4 to day 7, cyclophosphamide was administered intraperitoneally at a dose of 50 mg / kg daily.

[0034] Mice in the Drug group were administered the drug from day 1 of modeling until day 13. The Control and Model groups were given an equal volume of physiological saline. After the last administration, the mice were fasted overnight for 12 hours. The mice were weighed the following morning, and after anesthesia, their eyeballs were removed for blood collection. They were then euthanized by cervical dislocation, and their spleen, thymus, and other biological materials were dissected and collected for indicator testing.

[0035] Indicator Testing: 1. Running exhaustion test in mice and detection of rectal temperature, food intake, and water intake. Rectal temperature of mice was measured one day before sacrifice. The distance run by the mice on an animal treadmill was then recorded. Simultaneously, food and water intake in the 24 hours prior to sacrifice were calculated and recorded.

[0036] 2. Organ Index Calculation Mice were euthanized by cervical dislocation, and the spleen and thymus were dissected. Surrounding connective tissue was removed, and the weight of the two organs was accurately measured using an electronic balance. Combined with the mouse's pre-euthanasia body weight, the organ index was calculated using the formula (organ weight = organ weight / body weight) to assess the function of the mouse's immune organs.

[0037] 3. Detection of mouse red blood cells and hemoglobin On day 14 of the experiment, peripheral blood was collected from mice using the enucleation method and injected into pre-labeled EDTA-2 anticoagulant tubes. The tubes were gently shaken to ensure thorough mixing of the blood and anticoagulant. Subsequently, a fully automated blood analyzer was used to detect and record the number of red blood cells and hemoglobin concentration to assess the hematopoietic function of the mice.

[0038] Results and Analysis: (1) Analysis of the results of the running exhaustion test in mice and the effects of the composition on rectal temperature, food intake and water intake in mice with qi and blood deficiency. Figure 1 Data showed that compared with the Control group, the Model group had significantly lower running distance, rectal temperature, food intake, and water intake. Compared with the Model group, the Drug group had significantly higher running distance, rectal temperature, food intake, and water intake, indicating that the composition can effectively improve the decreased exercise endurance, low body temperature, and insufficient food and water intake in mice with qi and blood deficiency, and has a significant regulatory and protective effect on the physiological functions of mice.

[0039] (2) Effects of the composition on the immune organs of mice with qi and blood deficiency like Figure 2 As shown, compared with the Control group, the spleen index and thymus index of mice in the Model group were significantly reduced. After intervention with the composition, the spleen index and thymus index of mice in the Drug group were significantly increased, suggesting that the composition can improve the atrophy of immune organs in mice with qi and blood deficiency and enhance the body's immune function.

[0040] (3) Effects of the composition on the number of red blood cells and hemoglobin content in mice with qi and blood deficiency like Figure 3 As shown, compared with the Control group, the Model group mice showed a significant decrease in red blood cell count and hemoglobin concentration. Compared with the Model group, the Drug group significantly increased the decrease in red blood cell count and hemoglobin concentration induced by the modeling drug, indicating that the composition can effectively improve the anemia state of mice with qi and blood deficiency and has a significant protective and improving effect on the body's hematopoietic function.

[0041] In summary, the composition can improve symptoms such as low exercise endurance, low body temperature, insufficient food and water intake, atrophy of immune organs, and anemia in mice with qi and blood deficiency. It comprehensively regulates the physiological functions of mice and has a significant effect on improving the state of qi and blood deficiency.

[0042] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A medicinal and edible composition with the functions of invigorating qi and nourishing blood, characterized in that, It includes Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp.

2. The composition according to claim 1, characterized in that, The dosage of each ingredient in the composition is as follows: Angelica sinensis 3g, soybeans 60g, jujubes 57g, Astragalus membranaceus 18g, and longan pulp 54g.

3. A method for preparing the composition according to claim 1 or 2, characterized in that, Includes the following steps: 1) Soak the Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp in water to obtain a soaking material; 2) Boil the soaking material obtained in step 1), and dry the resulting decoction to obtain the composition.

4. The preparation method according to claim 3, characterized in that, Step 1) The total mass ratio of Angelica sinensis, soybeans, jujubes, Astragalus membranaceus, and longan pulp to water is 1:

10.

5. The preparation method according to claim 3, characterized in that, The soaking time in step 1) is 2 hours.

6. The preparation method according to claim 3, characterized in that, Step 2) The conditions for decocting include: decocting twice, 30 minutes each time.

7. The preparation method according to claim 3, characterized in that, Step 2) The drying conditions include: combining the decoctions obtained from two decoctions and filtering them, concentrating the filtrate to obtain an extract, and drying the extract at 60°C to constant weight to obtain the composition.

8. The use of the composition according to claim 1 or 2 in the preparation of qi-tonifying and blood-nourishing products.

9. A composition having the function of invigorating qi and nourishing blood, comprising the composition of claim 1 or 2 and food-acceptable excipients.

10. The composition according to claim 9, characterized in that, The dosage form of the composition includes decoction, granules, pills or capsules.

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