A multi-modal imaging apparatus

Abstract

The application belongs to the technical field of imaging, and provides a multi-mode imaging device, which mainly comprises a box body, a plurality of first imaging units, a first base, and a stage. The plurality of first imaging units are arranged at intervals in the box body and can provide imaging requirements of different wavelengths. The first base is arranged in the box body and is provided with a first support. The first support is provided with a first lens which is arranged obliquely. The first support is arranged to rotate relative to the first base. The stage is arranged in the box body and is provided with a stage surface. The stage surface is arranged close to one side of the first lens. The position of the first lens can correspond to the position of the stage so that part or all of the stage surface is transmitted to the first imaging unit through the first lens. Through the above arrangement, imaging shooting in different wavelength light environments can be realized only by rotating the first support, and multi-mode imaging requirements can be met.

Description

Technical Field

[0001] This invention belongs to the field of imaging technology, and in particular refers to a multi-mode imaging device. Background Technology

[0002] Vivo imaging technology, primarily encompassing bioluminescence and fluorescence, is commonly used for labeling within animals. Utilizing a highly sensitive optical detection system, researchers can directly monitor cellular activity and gene behavior within living organisms. This system allows for the observation of biological processes in living animals, such as tumor growth and metastasis, the development of infectious diseases, and the expression of specific genes. Therefore, visible light imaging technology is widely used in the research and treatment of cancer.

[0003] In the existing technology, imaging devices are relatively simple and can usually only perform imaging experiments under visible light in a specific wavelength range. However, imaging equipment is very expensive. Therefore, limited imaging experimental needs can usually be met by using only one or a few imaging devices, and it is impossible to perform full-band visible light imaging experiments. Furthermore, if the imaging devices are simply stacked, they require a lot of space, increasing the size and weight of the equipment. Therefore, it is necessary to improve the existing single imaging devices to meet various imaging experimental needs. Summary of the Invention

[0004] This invention provides a multi-mode imaging device that solves the problems of single imaging mode and large size of existing imaging devices.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A multi-mode imaging device, comprising:

[0007] The box has a first cavity;

[0008] Multiple first imaging units are disposed in the first cavity of the housing. The multiple first imaging units can provide imaging requirements for different wavelengths. The multiple first imaging units are arranged at intervals in the housing.

[0009] A first base is disposed inside the box. A first support is provided on the first base. A first lens is provided on the first support. The first lens is tilted. The first support is rotatably disposed relative to the first base.

[0010] A stage is disposed inside the housing. The stage has a loading surface, which is positioned close to the first lens. The position of the first lens can correspond to the position of the stage, so that part or all of the loading surface is transmitted to the first imaging unit through the first lens.

[0011] In some embodiments, a plurality of the first imaging units are circumferentially distributed within the housing, and the imaging center axes of the lenses of the plurality of the first imaging units are located in the same plane.

[0012] In some implementations, the angle between the imaging center axes of the lenses of two adjacent first imaging units is the same.

[0013] In some embodiments, a first support is also provided inside the housing, and the first base is provided on the first support, and the first base can reciprocate linearly on the first support.

[0014] In some embodiments, a second imaging unit is provided inside the housing, and a first lens is provided on the first base. The first lens corresponds to the position of the first lens. When light passes through the first lens, the light passes through the first lens and reaches the lens of the second imaging unit.

[0015] In some embodiments, a second base is further provided on the first support, the second base is provided with a second support, and the second support is provided with a second lens. The second base can reciprocate linearly on the first support, and its reciprocating linear movement direction is consistent with the reciprocating movement direction of the first base. The second support is rotatably disposed on the second base.

[0016] In some embodiments, the second base is provided with a second lens, which corresponds to the position of the second lens. Light is transmitted through the second lens and passes through the second lens to the lens of the second imaging unit.

[0017] In some embodiments, the first support is vertically mounted inside the box, with its lifting direction perpendicular to the loading surface of the platform.

[0018] In some embodiments, the system further includes a plurality of third imaging units disposed within the housing, the plurality of third imaging units being circumferentially spaced apart, and the plurality of third imaging units being disposed below the plurality of first imaging units;

[0019] A second support is disposed below the first support. The second support is provided with at least one optical path conversion module. The optical path conversion module includes a third base and a third support rotatably disposed on the third base. The third base can reciprocate linearly relative to the second support. A third lens is disposed on the third support at an angle. The third lens corresponds to the position of the stage so that part or all of the surface of the object is transmitted to the third imaging unit through the third lens.

[0020] In some embodiments, the third base is provided with a third lens, the third lens being positioned corresponding to the third lens, and light passing through the third lens and through the third lens to the lens of the second imaging unit.

[0021] In some embodiments, the imaging center axes of the lenses of the plurality of third imaging units are located in the same plane.

[0022] In some embodiments, the included angle between the imaging center axes of two adjacent third imaging units is the same.

[0023] In some embodiments, the second bracket is vertically detachable within the housing, and the reciprocating direction of the third base is perpendicular to the reciprocating direction of the first base.

[0024] In some embodiments, both the first and second supports are provided with clearance space so that the stage is fully exposed to the imaging angle of the lens of the second imaging unit.

[0025] In some embodiments, the platform is vertically mounted inside the box, and the platform is rotatable relative to the box. The lifting direction of the platform is perpendicular to the rotation direction of the first support.

[0026] In some embodiments, the first imaging unit, the second imaging unit, and the third imaging unit are each provided with different types of filters, so that each of the first imaging unit, the second imaging unit, and the third imaging unit can receive light of different wavelengths.

[0027] Compared with the prior art, the beneficial effects of this invention are:

[0028] This application achieves imaging of light of any wavelength by arranging multiple first imaging units within a housing, each unit meeting the imaging requirements of different wavelengths of light. The first imaging units are circumferentially spaced within the housing. A first base is provided within the housing, and a rotatable first support is mounted on the first base. An inclined first lens is mounted on the first support, with the first lens corresponding to the position of the stage. By rotating the first support relative to the first base, the first lens rotates, allowing the surface of the stage to be exposed within the imaging field of view of each first imaging unit. This enables imaging of light of any wavelength, fulfilling multi-mode imaging requirements. Simultaneously, the reflection by the first lens shortens the space required for actual light transmission, minimizing the overall size of the device while meeting multi-mode imaging needs.

[0029] Additional aspects and advantages of this application will be set forth in part in the description which follows, and will become apparent from the description or may be learned by practice of this application. Attached Figure Description

[0030] Figure 1 This is a perspective view of a multi-mode imaging device of the present invention without the housing;

[0031] Figure 2 for Figure 1 Side view in the middle;

[0032] Figure 3 for Figure 1 Top view in the middle;

[0033] Figure 4 This is a first schematic diagram of the first support of the multi-mode imaging device of the present invention;

[0034] Figure 5 This is a second schematic diagram of the first support of the multi-mode imaging device of the present invention;

[0035] Figure 6 This is a first schematic diagram of light transmission in the multi-mode imaging device of the present invention;

[0036] Figure 7 This is a second schematic diagram of light transmission in the multi-mode imaging device of the present invention. Detailed Implementation

[0037] The present application will be further described in detail below with reference to the accompanying drawings. In the description of the embodiments, unless otherwise stated, the terms "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the present application must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the present application.

[0038] like Figure 1-5 As shown, a multi-mode imaging device provided by the present invention mainly includes a housing with a first cavity, which provides a dark field environment for imaging; multiple first imaging units 10 are disposed in the first cavity of the housing, wherein the multiple first imaging units 10 can meet the imaging requirements of light of different wavelengths, such as imaging environments provided by different light sources such as infrared region I, infrared region II, fluorescence imaging, or ultraviolet light; the multiple first imaging units 10 are arranged at intervals inside the housing, and each first imaging unit 10 includes a camera and a lens, and a filter can be set in front of the lens or between the lens and the camera to realize imaging and shooting of different light sources;

[0039] A first base 11 is disposed within the housing. A first support 112 is provided on the first base 11, and a first lens 1121 is provided on the first support 112. The first lens 1121 is tilted. In this embodiment, the tilt angle is 45 degrees. It should be noted that the first support 112 and the first base are movably connected, and the first support 112 can rotate relative to the first base 11. In this embodiment, the plane formed by the rotation of the first support 112 is parallel to the loading surface of the stage 4. By rotating the first support 112, the first lens 1121 can be made to face the lens of each first imaging unit 10. Combined with the aforementioned, each first imaging unit 10 can satisfy the imaging of light of a unique specific wavelength to meet the imaging requirements of the actual scene.

[0040] The stage 4 is disposed inside the box and located on the bottom wall 5 of the box. A loading surface is provided on the stage 4, and the loading surface is positioned facing the first lens 1121. The position of the first lens 1121 can correspond to the position of the stage 4, so that part or all of the loading surface is transmitted to the first imaging unit 10 through the first lens 1121. In this embodiment, the device is used for live animal imaging research, that is, the animal to be tested is placed on the loading surface. At this time, the first lens 1121 only plays a reflective role. Through the reflection of the first lens 1121, the head image of the animal to be tested can be reflected to the lens of the first imaging unit 10, thereby completing the imaging of the live animal.

[0041] This application covers imaging processing of all wavelengths of light by setting up multiple first imaging units 10. Each first imaging unit 10 is configured as an imaging device for a specific wavelength according to the requirements. By accumulating the effects of multiple different first imaging units 10, full wavelength imaging coverage is achieved. At the same time, by rotating the first support 112, the first lens 1121 on the first support 112 is driven to rotate, so that the first lens 1121 faces one of the first imaging units 10. The viewing angle on the stage 4 is reflected by the first lens 1121 and transmitted to each first imaging unit 10, thereby fulfilling the imaging requirements of different wavelengths of light required in practice.

[0042] In this embodiment, the structure in which the first support 112 rotates relative to the first base 11 can be a gear ring structure or a synchronous belt and synchronous pulley rotation structure. The rotation structure is not the focus of this application. The purpose is simply for the first support 112 to drive the first lens 1121 to rotate.

[0043] Furthermore, such as Figure 2 and Figure 3As shown, for ease of operation, imaging at various specific wavelengths can be achieved simply by rotating the first support 112. Multiple first imaging units 10 are circumferentially distributed within the housing, and the imaging center axes of the lenses of the multiple first imaging units 10 are located in the same plane. Figure 2 As shown, the red line is the first plane 101 formed by the imaging center axis of the lenses of the multiple first imaging units 10.

[0044] Furthermore, such as Figure 3 As shown, the included angle 1011 between the imaging center axes of the lenses of two adjacent first imaging units 10 is the same. In this embodiment, there are 5 first imaging units 10, and the included angle 1011 between the imaging center axes of the lenses of two adjacent first imaging units 10 is 45 degrees. With this setting, the first support 112 only needs to rotate 45 degrees or an integer multiple of 45 degrees each time during rotation, so that the first lens 1121 is directly facing the stage 4 and one of the first imaging units 10, which facilitates the electronic control setting and adjustment of the rotation device.

[0045] Optionally, the included angle 1011 can be set according to actual needs, and a preset value can be set based on the installation space required by the first imaging unit 10 to avoid spatial interference. The size of the included angle 1011 is not limited by the present invention and can be set reasonably according to actual needs. For example, 30 degrees, 40 degrees, 41 degrees or 50 degrees, etc.

[0046] In one embodiment, the device further includes a first support 1 disposed within the housing, and a first base 11 disposed on the first support 1 to provide a support position for the first base 11, wherein the first base 11 can reciprocate linearly on the first support 1.

[0047] Furthermore, a second imaging unit 20 is installed in the upper space of the housing. By movably mounting the first base 11 on the first support 1, when the first base 11 moves away from directly above the stage 4, the second imaging unit 20 can directly image and capture images of the stage 4. Figure 2 As shown.

[0048] In this embodiment, the reciprocating linear movement of the first base 11 can be achieved by a screw-slider structure combined with a guide rod for limiting, or by a synchronous belt and synchronous wheel combined with a guide rod for limiting. The motion mechanism is not the focus of this application; the focus is on achieving the reciprocating linear movement of the first base 11.

[0049] Furthermore, a first lens 111 is provided on the first base 11, and the first lens 111 corresponds in position to the first lens 1121, such as... Figure 4-7As shown. At this time, the first lens 1121 has light-transmitting capability, such as a dichroic mirror. Light passes through the first lens 1121 and then through the first split lens 111 to reach the lens of the second imaging unit 20 for imaging. In this embodiment, the first split lens 111 can be a filter or another different dichroic mirror, which can be preset according to experimental requirements. In this embodiment, when the first lens 1121 is a dichroic mirror, imaging can be performed simultaneously on the first imaging unit 10 and the second imaging unit 20, and its light transmission path is as follows... Figure 6 As shown.

[0050] In one embodiment, to enable imaging options for multiple imaging combinations and facilitate the selection of the first lens 1121 by experimental personnel according to their needs, a second base 12 is provided on the first support 1, a second support 122 is provided on the second base 12, and a second lens 1221 is provided on the second support 122. The second base 12 can reciprocate linearly on the first support 1, and its reciprocating linear movement direction is consistent with the reciprocating movement direction of the first base 11. The second support 122 is rotatably mounted on the second base 12. In this embodiment, the second base 12, the second support 122, and the rotation structure of the second support 122 are all completely consistent with the structures of the first base 11 and the first support 112. The second lens 1221 can be selectively configured according to actual imaging requirements. For example, when the first lens 1121 is a dichroic mirror, the second lens 1221 can be a pure reflective mirror or another different type of dichroic mirror, achieving multiple imaging combinations.

[0051] Furthermore, a second mirror 121 is provided on the second base 12. The second mirror 121 corresponds to the second mirror 1221 in position. Light is transmitted through the second mirror 1221 and then through the second mirror 121 to the lens of the second imaging unit 20. In this embodiment, the first mirror 1121 and the second mirror 1221 can be the same reflector or different dichroic mirrors; the first mirror 111 and the second mirror 121 also have different structures. The second mirror 121 can be a dichroic mirror or a filter, and can be selectively set according to actual needs to meet various imaging and shooting requirements.

[0052] When imaging is required under a specific wavelength of light source, the first lens 1121 or the second lens 1221 can be moved to directly above the stage 4 by moving the first base 11 and the second base 12 to perform imaging. Alternatively, both the first base 11 and the second base 12 can be moved away from above the stage 4 to create clearance space, allowing the lens of the second imaging unit 20 to directly image the stage 4.

[0053] Furthermore, to facilitate position adjustment, the first support 1 can be raised and lowered within the box, with its raising and lowering direction perpendicular to the loading surface of the platform 4, i.e. Figure 2 The vertical direction is shown. This ensures that the centers of the first lens 1121 and the second lens 1221 correspond to the imaging center axis of the lens of the first imaging unit 10, achieving the best imaging effect. In this embodiment, the lifting structure of the first support 1 can be a screw and nut combined with a guide rod structure, or a synchronous belt and synchronous wheel combined with a guide rod structure, or a cylinder lifting structure. Its lifting structure is not limited by the present invention, as long as the first support 1 can be adjusted in height within the housing.

[0054] In one embodiment, in order to meet the imaging and shooting of light across the entire spectrum and reduce the space required for the housing, a plurality of third imaging units 20 are also provided in the housing. The plurality of third imaging units 20 are distributed circumferentially at intervals, consistent with the distribution of the plurality of second imaging units 20. The plurality of third imaging units 30 are disposed below the plurality of first imaging units 10.

[0055] A second support 2 is positioned below the first support 1, and the second support 2 is equipped with at least one optical path conversion module for optical path conversion. In this embodiment, there are two optical path conversion modules, such as... Figure 1 As shown, the optical path conversion module includes a third base and a third support rotatably mounted on the third base. The third base is mounted on the second support 2 and can reciprocate linearly relative to the second support 2. The third support is provided with an inclined third lens. When the third base is directly above the stage 4, the third lens can correspond to the position of the stage 4, so that part or all of the surface of the object is transmitted to the third imaging unit 30 through the third lens. In this embodiment, the structure of the third base and the third support is the same as the structure of the first base 11 and the first support 112.

[0056] In this embodiment, to avoid interference between the first support 1 and the second support 2, the first support 1 and the second support 2 are arranged in an alternating manner. As the best implementation, the first support 1 is arranged perpendicularly to the second support 2 in space, such as... Figure 3 As shown, at this time, the first lens 1121 and the second lens 1221 are facing the lens of one of the first imaging units 10.

[0057] Furthermore, a third lens is provided on the third base. The third lens corresponds to the position of the third lens. Light passes through the third lens and through the third lens to the lens of the second imaging unit 20. Its principle is the same as that of the first lens 1121 and the first lens 111, as mentioned above, and will not be elaborated further here.

[0058] In one embodiment, the imaging center axis of the lens of the third imaging unit 30 lies in the same plane. For example... Figure 2As shown, the second plane 201 (marked in blue) contains the imaging center axes of the lenses of the multiple third imaging units 30. With this configuration, simply rotating the third support aligns the third lens with the center axis of the lens of each third imaging unit 30. The layered arrangement of the third and first imaging units reduces the required installation space.

[0059] Furthermore, the angle between the imaging center axes of two adjacent third imaging units 30 is the same. Their distribution structure and principle are the same as those of the first imaging unit 10, as previously described, and will not be elaborated upon here. In this embodiment, the upper and lower layer positions of the multiple first imaging units and the multiple third imaging units correspond one-to-one, thereby simplifying the control structure.

[0060] In one embodiment, the second bracket 2 can reciprocate linearly up and down within the housing to align the third lens with the imaging center axis of the lens of the third imaging unit. Its principle is the same as the lifting structure of the first bracket 1, and will not be elaborated further here.

[0061] Furthermore, the third base is movably mounted on the second support 2, and the third base can reciprocate linearly relative to the second support, with the reciprocating direction of the third base perpendicular to the reciprocating direction of the first base 11. This arrangement avoids interference between the movements of the first support 1 and the second support 2, and also ensures that the first lens 1121 faces one of the first imaging units 10, and the third lens faces one of the third imaging units 30, simplifying imaging control.

[0062] In one embodiment, to avoid interference from the first support 1 and the second support 2 on the imaging of the second imaging unit 20, clearance spaces are provided on both the first support 1 and the second support 2. In this embodiment, both the first support 1 and the second support 2 are composed of two rods, with a preset distance between the two rods to form clearance spaces. While ensuring the linear movement of the first base 11 and the third base, a certain clearance space can also be formed. When the first base 11, the second base 12, and the third base are not directly above the stage 4, the stage 4 is completely exposed to the imaging field of view of the lens of the second imaging unit 20. At this time, the lens of the second imaging unit 20 can fully cover the stage for imaging.

[0063] Furthermore, to enable the second imaging unit 20 to better image and capture images of the stage 4 and adjust the object distance, the stage 4 can be raised and lowered within the housing, with the raising and lowering direction of the stage 4 perpendicular to the rotation direction of the first support 112. By raising and lowering the stage 4, the object distance between the first lens 1121 or the lens of the second imaging unit 20 can be adjusted to achieve the best shooting effect. Furthermore, the stage 4 can also rotate relative to the housing. This rotation allows the live animal on the stage 4 to be adjusted to different angles to achieve a suitable shooting angle, enabling the same camera to meet shooting needs from different angles. In this embodiment, the stage 4 has a circular structure, with its center being the rotation center. The shape of the stage 4 is not limited, as long as it can rotate within the housing.

[0064] In one embodiment, to achieve imaging of light across the entire wavelength range, the first imaging unit 10, the second imaging unit 20, and the third imaging unit 30 are each equipped with different types of filters, enabling each of these units to receive light in different wavelength bands, thus achieving imaging of light across the entire wavelength range. The structures of the first imaging unit 10, the second imaging unit 20, and the third imaging unit 30 are as shown in application number 202511062155.2, and will not be described in detail here.

[0065] The above description is merely a preferred embodiment of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention. These improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A multi-mode imaging device, characterized in that, include: The box has a first cavity; Multiple first imaging units are disposed in the first cavity of the housing. The multiple first imaging units can provide imaging requirements for different wavelengths. The multiple first imaging units are arranged at intervals in the housing. A first base is disposed inside the box. A first support is provided on the first base. A first lens is provided on the first support. The first lens is tilted. The first support is rotatably disposed relative to the first base. A stage is disposed inside the housing. The stage has a loading surface, which is positioned close to the first lens. The position of the first lens can correspond to the position of the stage, so that part or all of the loading surface is transmitted to the first imaging unit through the first lens.

2. The multi-mode imaging device according to claim 1, characterized in that, Multiple first imaging units are circumferentially distributed within the housing, and the imaging center axes of the lenses of the multiple first imaging units are located in the same plane.

3. The multi-mode imaging device according to claim 2, characterized in that, The angle between the imaging center axes of two adjacent first imaging units is the same.

4. The multi-mode imaging device according to claim 1, characterized in that, It also includes a first support disposed inside the box, and a first base disposed on the first support, the first base being capable of reciprocating linear movement on the first support.

5. A multi-mode imaging device according to claim 4, characterized in that, The housing contains a second imaging unit, and the first base has a first lens. The first lens corresponds to the position of the first lens. When light passes through the first lens, the light passes through the first lens and reaches the lens of the second imaging unit.

6. A multi-mode imaging device according to claim 4, characterized in that, It also includes a second base disposed on the first bracket, the second base having a second support and a second lens disposed on the second support, wherein the second base can reciprocate linearly on the first bracket, and its reciprocating linear movement direction is consistent with the reciprocating movement direction of the first base, and the second support is rotatably disposed on the second base.

7. A multi-mode imaging device according to claim 6, characterized in that, The second base is provided with a second lens, which corresponds to the position of the second lens. Light is transmitted through the second lens and then through the second lens to the lens of the second imaging unit.

8. A multi-mode imaging device according to claim 4, characterized in that, The first support is vertically mounted inside the box, and its lifting direction is perpendicular to the loading surface of the platform.

9. A multi-mode imaging device according to claim 5, characterized in that, It also includes a plurality of third imaging units disposed within the housing, the plurality of third imaging units being circumferentially spaced apart, and the plurality of third imaging units being disposed below the plurality of first imaging units; A second support is disposed below the first support. The second support is provided with at least one optical path conversion module. The optical path conversion module includes a third base and a third support rotatably disposed on the third base. The third base can reciprocate linearly relative to the second support. A third lens is disposed on the third support at an angle. The third lens corresponds to the position of the stage so that part or all of the surface of the object is transmitted to the third imaging unit through the third lens.

10. A multi-mode imaging device according to claim 9, characterized in that, The third base is provided with a third lens, which is positioned corresponding to the third lens. Light passes through the third lens and then through the third lens to the lens of the second imaging unit.

11. A multi-mode imaging device according to claim 9, characterized in that, The imaging center axes of the lenses of the multiple third imaging units are located in the same plane.

12. A multi-mode imaging device according to claim 11, characterized in that, The angle between the imaging center axes of the lenses of two adjacent third imaging units is the same.

13. A multi-mode imaging device according to claim 9, characterized in that, The second bracket is vertically adjustable within the housing, and the reciprocating direction of the third base is perpendicular to the reciprocating direction of the first base.

14. A multi-mode imaging device according to claim 9, characterized in that, Both the first and second supports are provided with clearance space so that the stage is fully exposed to the imaging angle of the lens of the second imaging unit.

15. A multi-mode imaging device according to claim 1, characterized in that, The platform is vertically mounted inside the box, and the platform is rotatable relative to the box. The lifting direction of the platform is perpendicular to the rotation direction of the first support.

16. A multi-mode imaging device according to claim 9, characterized in that, The first imaging unit, the second imaging unit, and the third imaging unit are each equipped with different types of filters so that each of the first imaging unit, the second imaging unit, and the third imaging unit can receive light of different wavelengths.

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