A safe antibacterial heating patch with stable heating and a preparation method thereof

Abstract

The application relates to the technical field of warm pads, and particularly discloses a safe antibacterial warm pad with stable heating and a preparation method thereof. The safe antibacterial warm pad with stable heating comprises a gelatin layer, a non-woven fabric bag made of antibacterial melt-blown cloth and antibacterial heating materials filled in the non-woven fabric bag, the gelatin layer is attached to the surface of the non-woven fabric bag, the antibacterial melt-blown cloth comprises melt-blown polypropylene master batches and compounded antibacterial agents; the compounded antibacterial agents comprise the following raw materials: a nano-silver ion antibacterial agent, nano-zinc oxide, sharp-titanium type nano-titanium dioxide and magnesium stearate. The obtained warm pad has the highest antibacterial rates of 99.8% and 99.9% respectively after 4 hours and 8 hours, has high antibacterial property, and the antibacterial time efficiency is basically synchronous with the heating time length of the warm pad, so that the whole process protection during the use of the warm pad can be realized.

Description

Technical Field

[0001] This application relates to the field of heat patch technology, and more specifically, it relates to a safe antibacterial heat patch with stable heating and a method for preparing the same. Background Technology

[0002] Heat packs, also known as hand warmers, are portable, instant-heating products invented in Japan in the 1970s. Large-scale production began in China in 2006, and after more than two decades of development, they have become widely popular. The heating principle of heat packs utilizes a self-heating system composed of iron powder, activated carbon, and inorganic salts. Through an oxidation-reduction reaction with oxygen in the air, chemical energy is converted into heat energy. The heating rate and duration are controlled by the oxygen permeability of the breathable membrane, thus providing continuous warmth to a localized area of ​​the body. They can also be used for joint heat therapy to relieve pain and improve peripheral blood circulation. Traditional heat packs typically include a breathable inner bag to hold the heating material, a sealed outer bag to isolate the air, and a gelatin layer for easy contact with skin or clothing. With the increasing trend of health-conscious consumption, consumer demand for heat packs has evolved from simply providing warmth to providing warmth, health, and safety.

[0003] Heat patches are typically worn close to underwear in hot, humid environments, sometimes needing to be worn for five, six, or even ten hours or more. This makes them highly susceptible to bacterial growth, potentially leading to skin flora imbalance and even skin infections. Even after removing the heat patch, the risk of bacterial residue remains at the application site. For menstruating women, those with sensitive skin, or people who spend long periods outdoors without being able to change their heat patches, antibacterial properties are particularly important. However, current industry standards do not specify antibacterial or sterile requirements during the production of heat patches, and the raw materials used are not sterilized, making it difficult to address the risk of bacterial residue.

[0004] Therefore, it is necessary to develop a safe antibacterial heat patch with high antibacterial properties and stable heating. Summary of the Invention

[0005] In order to make the heat patch have high antibacterial properties, this application provides a safe antibacterial heat patch with stable heating.

[0006] In a first aspect, this application provides a safe antibacterial heat patch with stable heating, which adopts the following technical solution: A safe antibacterial heat patch with stable heating includes a gelatin layer, a non-woven bag made of antibacterial meltblown fabric, and an antibacterial heating material filled inside the non-woven bag, wherein the gelatin layer is adhered to the surface of the non-woven bag. Based on the total mass of the antibacterial meltblown fabric, the antibacterial meltblown fabric comprises the following raw materials in parts by weight: 90-100 parts of meltblown polypropylene masterbatch and 1-10 parts of compound antibacterial agent; Based on the total mass of the compound antibacterial agent, the compound antibacterial agent comprises the following raw materials in parts by weight: 25-30 parts of nano silver ion antibacterial agent, 20-25 parts of nano zinc oxide, 15-20 parts of anatase nano titanium dioxide, and 4-6 parts of magnesium stearate. The raw materials of the antibacterial heating material contain heating system antibacterial agents and heating system antibacterial microcapsules; the heating system antibacterial microcapsules are quaternary ammonium salt antibacterial agents with a surface coating of hot-melt material.

[0007] By adopting the above technical solution, a non-woven bag made of antibacterial meltblown fabric is prepared and filled with antibacterial heating material, so that the heat patch has the effects of long-lasting broad-spectrum antibacterial, safe and skin-friendly, and stable heating performance.

[0008] Adding a compound antibacterial agent to meltblown polypropylene masterbatch imparts antibacterial properties to the meltblown fabric. Specifically, nano-silver ion antibacterial agents slowly release silver ions under warm conditions, disrupting cell membrane integrity, inhibiting enzyme activity, and blocking bacterial energy metabolism and DNA replication, ultimately achieving a bactericidal effect. Nano-zinc oxide releases zinc ions, damaging bacterial cell membranes and interfering with metabolism; it can also physically puncture bacterial cell membranes, accelerating the loss of intracellular substances. The porous structure of anatase nano-titanium dioxide adsorbs nano-silver ion particles, preventing the aggregation of nano-silver ion antibacterial agents and nano-zinc oxide ions in the meltblown polypropylene masterbatch system. Simultaneously, it binds to silver and zinc ions through surface hydroxyl groups, regulating the silver ion release rate, ensuring both bactericidal efficacy and extended antibacterial duration.

[0009] By incorporating an antibacterial agent into the heating system, bacterial growth in warm and humid environments is inhibited without interfering with the core heating function of the heat patch, and the antibacterial effect is precisely matched with the heating duration of the heat patch. Quaternary ammonium salt antibacterial agents are added as antibacterial microcapsules to the surface of the heat-melting material. When the heat patch heats up to 35-65℃, the surface heat-melting material melts, releasing the internal quaternary ammonium salt antibacterial agents, extending the antibacterial effect. The simultaneous addition of both the heating system antibacterial agent and the antibacterial microcapsules ensures a continuous output of antibacterial components throughout the entire heating period of the heat patch.

[0010] Preferably, based on the total mass of the antibacterial heating material, the antibacterial heating material comprises the following raw materials in parts by weight: 40-60 parts iron powder, 4-8 parts vermiculite, 10-20 parts activated carbon powder, 3-5 parts antibacterial agent for the heating system, 2-3 parts antibacterial microcapsules for the heating system, 1-3 parts inorganic salt, and 70-100 parts water; the antibacterial microcapsules for the heating system are antibacterial agents with a surface coating of a heat-fusible material.

[0011] By adopting the above scheme, the antibacterial heating material uses iron powder as raw material. The iron powder reacts with oxygen in the air to produce an oxidation reaction, which releases a large amount of heat. Vermiculite is a layered porous silicate mineral. Its porous structure can adsorb a large amount of moisture, maintain the humid environment required for the heating reaction, and prevent the reaction from being interrupted due to rapid evaporation of moisture. The layered structure has a low thermal conductivity, which can lock in the heat generated by the oxidation of iron powder, reduce heat loss, and prolong the heating time of the heat pack. In addition, it adsorbs particles such as iron powder and activated carbon to prevent the heating material from clumping due to the reaction and ensures that the heat is released evenly.

[0012] Activated carbon powder and iron powder form a galvanic cell structure, with activated carbon as the positive electrode, iron powder as the negative electrode, and the electrolyte solution as the conductive medium. This significantly accelerates the oxygen absorption corrosion rate of the iron powder, allowing the heat patch to rapidly heat up to 50-65℃ within 5-10 minutes. Activated carbon adsorbs oxygen from the air, continuously providing an oxidant for the heating reaction, while also adsorbing antibacterial components, improving the uniformity of dispersion of the antibacterial agent and antibacterial microcapsules in the heating material. Inorganic salts enhance the conductivity of the iron powder-activated carbon galvanic cell, accelerate electron transfer, thereby accelerating the oxidation rate of iron powder, reducing the surface tension of water, promoting water penetration to the surface of iron powder particles, maintaining a continuous oxygen absorption corrosion reaction, and accelerating the heating reaction. Adding water to wet all components ensures the fluidity and uniformity of the heating material, while also promoting the slow release of antibacterial ions from the antibacterial agent in the heating system, meeting the moisture requirements throughout the heating reaction and preventing the heat patch from drying out and failing prematurely.

[0013] By incorporating an antibacterial agent into the heating system, bacterial growth in warm and humid environments is inhibited without interfering with the core heating function of the heat patch, and the antibacterial effect is precisely matched with the heating duration of the heat patch. Quaternary ammonium salt antibacterial agents are added as antibacterial microcapsules to the surface of the heat-melting material. When the heat patch heats up to 35-65℃, the surface heat-melting material melts, releasing the internal quaternary ammonium salt antibacterial agents, extending the antibacterial effect. The simultaneous addition of both the heating system antibacterial agent and the antibacterial microcapsules ensures a continuous output of antibacterial components throughout the entire heating period of the heat patch.

[0014] Preferably, the antibacterial microcapsules of the heating system are prepared by the following steps: S1. Heat the hot-melt material PEG-1000 until it is completely melted, add the quaternary ammonium salt antibacterial agent, stir, and get the mixture A. Pour the mixture A into deionized water at 25°C and stir continuously to get antibacterial microcapsules A. S2. Heat the hot-melt material PEG-1500 until it is completely melted, add the quaternary ammonium salt antibacterial agent, stir, and get the mixture B. Pour the mixture B into deionized water at 25°C and stir continuously to get the antibacterial microcapsules B. S3. Heat the hot-melt material PEG-2000 until it is completely melted, add the quaternary ammonium salt antibacterial agent, stir, and obtain a mixture C. Pour the mixture C into deionized water at 25°C and stir continuously to obtain antibacterial microcapsules C. S4. Mix antibacterial microcapsules A, B and C in proportion, dry them, and obtain the heating system antibacterial microcapsules. The heat-melting material is PEG of different molecular weights. The heat-melting material used in antibacterial microcapsule A is PEG-1000, the heat-melting material used in antibacterial microcapsule B is PEG-1500, and the heat-melting material used in antibacterial microcapsule C is PEG-2000.

[0015] By adopting the above scheme, antibacterial microcapsules A, B, and C were obtained by coating quaternary ammonium salt antibacterial agents with PEG of different molecular weights. PEG with a molecular weight of 1000 melts first at the initial stage of the heat patch heating, i.e., 35-40℃. After the shell of antibacterial microcapsule A melts, the first batch of quaternary ammonium salt antibacterial agents is released, inhibiting the initial growth of bacteria in the heating material in advance. When the heat patch heats up to 40-45℃, the shell of PEG-1500 melts, releasing the second batch of quaternary ammonium salt antibacterial agents, connecting the antibacterial activity and avoiding the "antibacterial window period". When the temperature of the heat patch is 45-65℃, the shell of PEG-2000 melts, releasing the third batch of quaternary ammonium salt antibacterial agents. The antibacterial microcapsules of the heating system melt in a stepwise manner, releasing the internal quaternary ammonium salt antibacterial agents batch by batch, ensuring continuous output of antibacterial components throughout the entire heating period of the heat patch, and improving the antibacterial properties of the heat patch.

[0016] Preferably, the mass ratio of the antibacterial microcapsules A, B, and C is 2:3:5.

[0017] By adopting the above technical solution, the mass ratio of antibacterial microcapsules A, B, and C is controlled at 2:3:5, and the release of quaternary ammonium salt antibacterial agents is ensured by coordinating the temperature range of each stage, thereby further improving the antibacterial properties of the heat patch, extending the antibacterial effect, and ensuring the continuous output of antibacterial components throughout the entire heating period of the heat patch.

[0018] As a preferred embodiment, the antibacterial agent of the heating system comprises the following raw materials in parts by weight, based on the total mass of the antibacterial agent in the heating system: 4-8 parts of nano silver ion antibacterial agent, 4-6 parts of nano zinc oxide, 3-5 parts of nano copper oxide, 1-2 parts of nano tourmaline powder, 3-5 parts of carvacrol, 1-3 parts of p-cymene, 1-1.5 parts of silane coupling agent, and 0.5-1 parts of chitosan quaternary ammonium salt.

[0019] By employing the above technical solutions, the nano-silver ion antibacterial agent in the heating system releases silver ions, which penetrate the bacterial cell membrane, resulting in high bactericidal efficiency. Nano-zinc oxide releases zinc ions, balancing the ions in the bacterial cell membrane. Its surface hydroxyl groups coordinate with silver and copper ions, regulating the sustained-release efficiency of silver and copper ions. The addition of nano-copper oxide releases copper ions, targeting and inhibiting fungi, compensating for the weak antifungal activity of nano-silver ions and nano-zinc oxide. The porous layered structure of nano-tourmaline powder can load nano-silver ions, nano-zinc oxide, and nano-copper oxide, improving their dispersibility in the heating material system. Furthermore, the nano-tourmaline powder itself can release trace amounts of negative ions, regulating the surface microenvironment of the heating material, inhibiting bacterial adhesion, and further enhancing the antibacterial properties of the heating material.

[0020] Carvacrol is low in cost, has good antibacterial effects, and exhibits high volatility at 40-70℃. The volatiles can penetrate bacterial cell membranes, disrupt metabolic systems, and exert a bactericidal effect, inhibiting bacteria, fungi, and molds. Para-cymene also has high volatility at 40-70℃, with its volatiles possessing high antibacterial properties. Furthermore, para-cymene enhances membrane permeability, assisting carvacrol in entering cells and further improving its antibacterial effect. The addition of carvacrol and para-cymene, which can volatilize at 40-70℃, creates gaseous antibacterial molecules that compensate for the limitations of nano-silver ion antibacterial agents and nano-zinc oxide, which can only kill bacteria directly in contact with the non-woven bag surface. This expands the contact blind zone of the antibacterial components, thereby enhancing the antibacterial effect of the heat pack. Furthermore, the working temperature of heat patches is generally 40-65℃, which is exactly the efficient volatilization range of carvacrol and paracymene antibacterial ingredients. When the heat patch heats up, the antibacterial ingredients will automatically release gaseous molecules as the temperature rises. The antibacterial effect is basically synchronized with the heating time of the heat patch, achieving full protection during the use of the heat patch. It is more suitable for special groups such as women during menstruation and those with sensitive skin. Bacteria are not easily generated when the heat patch is applied to the skin for a long time. Moreover, the antibacterial ingredients are highly safe, and the volatile odor of the antibacterial ingredients is mild and will not irritate the respiratory tract.

[0021] Simultaneous use of silane coupling agents and chitosan quaternary ammonium salts allows the silane coupling agent to penetrate into the tiny gaps or surface defects of nanoparticles, forming a precise chemical anchor. Chitosan quaternary ammonium salts, being polymers, can further coat the remaining sites on the particle surface, further improving the dispersibility of the antibacterial components and significantly enhancing the antibacterial effect. Furthermore, chitosan quaternary ammonium salts themselves possess contact bactericidal activity, providing a dual effect.

[0022] Preferably, the weight ratio of p-cymene to carvacrol is 1:(2-4).

[0023] By adopting the above scheme and adjusting the weight ratio of p-cymene to carvacrol, the antibacterial effect of carvacrol can be further enhanced, thereby improving the antibacterial properties of meltblown fabric.

[0024] Preferably, the weight ratio of the chitosan quaternary ammonium salt to the silane coupling agent is 1:(1.5-2.5).

[0025] By adopting the above technical solution and adjusting the weight ratio of chitosan quaternary ammonium salt to silane coupling agent, the dispersion uniformity of nano silver ion antibacterial agent, nano zinc oxide, nano copper oxide and nano tourmaline powder in antibacterial heating material can be further improved, thereby further enhancing the antibacterial properties of the heating material.

[0026] Secondly, this application provides a method for preparing any of the above-mentioned heat-stable, safe, antibacterial heat-conserving patches, which is specifically achieved through the following technical solution: A method for preparing a safe antibacterial heat patch with stable heat generation includes the following steps: S1. Add an antibacterial agent to meltblown polypropylene masterbatch to prepare antibacterial meltblown fabric; S2. Mix all the raw materials of the antibacterial heating material evenly, put them into a non-woven bag, seal them by heat pressing, attach the gelatin layer and the covering layer, and seal the whole thing to obtain a safe antibacterial heat patch with stable heating.

[0027] In summary, this application includes at least one of the following beneficial technical effects: (1) This application adds compound antibacterial agent to meltblown fabric raw material and adjusts the dosage to make the antibacterial rate of the heat patch 99.3% and 99.4% at 4h and 8h respectively, so that the heat patch has high antibacterial properties. When the heat patch is heated, the antibacterial effect is basically synchronized with the heating duration of the heat patch, so as to achieve full protection during the use of the heat patch.

[0028] (2) This application adds antibacterial agents and antibacterial microcapsules to the heating material and adjusts the mass ratio of antibacterial microcapsules A, B and C in the antibacterial microcapsules of the heating system to make the antibacterial rate of the heat patch 99.5% and 99.7% at 4h and 8h respectively, which can further improve the antibacterial properties of the heat patch and ensure that antibacterial components are continuously output during the entire heating period of the heat patch.

[0029] (3) This application adds p-cymene and carvacrol to the antibacterial agent of the heating system and adjusts the weight ratio of chitosan quaternary ammonium salt and silane coupling agent in the antibacterial agent of the heating system, so that the antibacterial rate of the heat patch is 99.8% and 99.9% at 4h and 8h, respectively, which can further improve the antibacterial properties of the heat patch. Detailed Implementation

[0030] The following detailed description, in conjunction with specific embodiments, further illustrates this application. All the raw materials used in this application are commercially available products and are intended to fully disclose the raw materials used in this application; they should not be construed as limiting the source of the raw materials. Specifically: meltblown polypropylene masterbatch, melt index 1500g / 10min, brand Dawn, grade Z-1500E; nano silver ion antibacterial agent, model JC-4750. The active ingredient content is 99%, with a particle size of 50nm; nano zinc oxide, with a particle size of 20nm; anatase nano titanium dioxide, with a particle size of 5nm; magnesium stearate, with an active ingredient content of 99%; iron powder, with a particle size of 20 mesh; vermiculite, with a particle size of 20 mesh; activated carbon powder, with a particle size of 200 mesh; inorganic salt, sodium chloride, with an active ingredient content of 99%; quaternary ammonium salt antibacterial agent, dodecyltrimethylammonium chloride, with an active ingredient content of 99%; PEG-1000, with an active ingredient content of 99%; PEG-1500, with an active ingredient content of 99%; PEG-2000, with an active ingredient content of 99%; nano copper oxide, with a particle size of 20nm; nano tourmaline powder, with a particle size of 20nm; carvacrol, with an active ingredient content of 99%; p-cymene, with an active ingredient content of 99%; silane coupling agent, KH750; chitosan quaternary ammonium salt, with an active ingredient content of 99%.

[0031] The following is an example of the preparation of antibacterial microcapsules for a heating system: Preparation Example 1 The antibacterial microcapsules of the heating system in Example 1 were prepared by the following steps: S1. Heat 30g of PEG-1000 to 45℃ until completely melted, add 2g of quaternary ammonium salt antibacterial agent, stir at 200r / min for 30min to obtain mixture A, add mixture A dropwise to 70mL of 25℃ deionized water at a dropping rate of 1mL / min, stir continuously at 350r / min for 30min, collect microcapsules by suction filtration, wash twice with 25℃ deionized water, and vacuum dry at 40℃ for 2h to obtain antibacterial microcapsules A; S2. Heat 30g of PEG-1500 to 55℃ until completely melted, add 2g of quaternary ammonium salt antibacterial agent, stir at 250r / min for 30min to obtain mixture B, add mixture B dropwise to 70mL of 25℃ deionized water at a dropping rate of 1mL / min, stir continuously at 400r / min for 30min, collect microcapsules by suction filtration, wash twice with 25℃ deionized water, and vacuum dry at 40℃ for 2h to obtain antibacterial microcapsules B; S3. Heat 30g of PEG-2000 to 60℃ until completely melted, add 2g of quaternary ammonium salt antibacterial agent, stir at 200r / min for 30min to obtain mixture C, add mixture C dropwise to 70mL of 25℃ deionized water at a dropping rate of 1mL / min, stir continuously at 300r / min for 30min, collect microcapsules by suction filtration, wash twice with 25℃ deionized water, and vacuum dry at 40℃ for 2h to obtain antibacterial microcapsules C; S4. Mix antibacterial microcapsules A, B and C in a ratio of 2:3:4 until homogeneous, and dry to obtain the heating system antibacterial microcapsules.

[0032] Preparation Examples 2-3 The preparation method of the heating system antibacterial microcapsules in Preparation Examples 2-3 is the same as that in Preparation Example 1, except that the amounts of antibacterial microcapsules A, B, and C are different. Antibacterial microcapsules A, B, and C are mixed in proportions of 2:3:5 and 2:3:6, respectively, with specific dosages as follows. The types and dosages of the remaining raw materials are the same as those in Preparation Example 1. Example

[0033] The heat-stable, safe, antibacterial heat patch of Example 1 was prepared through the following steps: S1. To prepare antibacterial meltblown fabric, add 8 kg of compound antibacterial agent to 95 kg of meltblown polypropylene masterbatch. Specifically, add the meltblown polypropylene masterbatch and compound antibacterial agent to a high-speed mixer at 1000 r / min and mix for 10 min to obtain a homogeneous mixture. Then, feed the mixture into a twin-screw extruder for melt extrusion. Set the temperatures of each section of the extruder from the hopper to the die as follows: feeding section 180℃, melting section 200℃, and mixing section 21℃. The temperature is set at 0℃, homogenization section at 200℃, extrusion die at 160℃, chamber at 200℃, drawing hot air at 220℃, extruder speed at 80 r / min. Fibers are deposited onto a receiving curtain to form a web at a receiving curtain speed of 1 m / min. After web formation, the web is lightly hot-pressed through hot rollers at 80-90℃, with a distance of 25 cm between the web and the spinneret, and a hot air pressure of 0.1-0.2 MPa. Finally, the web is cured at 25℃ for 24 hours to obtain antibacterial meltblown fabric. The compound antibacterial agent is mixed according to the types and dosages of the raw materials listed in Table 1.

[0034] S2. Mix the raw materials of the antibacterial heating material evenly according to the dosage in Table 2, put them into the antibacterial non-woven bag of the antibacterial meltblown cloth obtained in step S1, seal them by hot pressing, stick the gelatin layer, and seal the whole thing to obtain a safe antibacterial heat patch with stable heating.

[0035] The antibacterial microcapsules of the heating system were prepared by the following steps: 20g of PEG-2000 was heated to 60℃ and completely melted, 2g of quaternary ammonium salt antibacterial agent was added, and the mixture was stirred at 200r / min for 30min to obtain a mixture. The mixture was then added dropwise to 70mL of deionized water at 25℃ at a dropping rate of 1mL / min, and stirred continuously at 300r / min for 30min. The microcapsules were collected by suction filtration, washed twice with deionized water at 25℃, and vacuum dried at 40℃ for 2h to obtain the antibacterial microcapsules of the heating system.

[0036] The antibacterial agent for the heating system was prepared by mixing all the raw materials of the antibacterial agent for the heating system evenly according to the dosage in Table 3.

[0037] Table 1. Dosage of each raw material in the compound antibacterial agent for antibacterial meltblown fabric in Example 1 (kg)

[0038] Table 2. Dosage of each raw material in the antibacterial and exothermic material of Example 1 (kg)

[0039] Table 3. Dosage (kg) of each raw material in the antibacterial agent of the heating system in Example 1.

[0040] Examples 2-4 The heating-stable, safe antibacterial heat packs in Examples 2-4 are prepared in the same way as those in Example 1, using the same methods and raw materials. The difference is that the antibacterial microcapsules of the heating system are selected from the antibacterial microcapsules prepared in Examples 1-3, while the dosage of the remaining raw materials is the same as in Example 3.

[0041] Examples 5-8 The heat-stable, safe antibacterial heat patches of Examples 5-8 are prepared in the same way as those of Example 3 in terms of preparation method and raw material types. The difference lies in the different dosages of each raw material of the antibacterial agent in the heat-generating system of the antibacterial heating material. The specific dosages are shown in Table 4.

[0042] Table 4. Dosage (kg) of each raw material in the antibacterial and exothermic materials of Examples 5-8

[0043] Examples 9-12 The heat-stable, safe antibacterial heat patches of Examples 9-12 are prepared in the same way as those of Example 6 in terms of preparation method and raw material types. The difference lies in the different dosages of each raw material of the antibacterial agent in the heat-generating system of the antibacterial heating material. The specific dosages are shown in Table 5.

[0044] Table 5. Dosage (kg) of each raw material in the antibacterial and exothermic materials of Examples 9-12

[0045] Comparative Example 1 The antibacterial heat patch of Comparative Example 1 was prepared in the same way as that of Example 1, except that no compound antibacterial agent was added to the antibacterial meltblown fabric raw material, and the other raw materials and dosages were the same as those of Example 1.

[0046] Comparative Example 2 The antibacterial heat patch of Comparative Example 2 was prepared in the same way as that of Example 1, except that no antibacterial agent or antibacterial microcapsules of the heating system were added to the raw materials of the antibacterial heating material, while the other raw materials and dosages were the same as those of Example 1.

[0047] Comparative Example 3 The antibacterial heat patch of Comparative Example 3 was prepared in the same way as that of Example 1, except that no antibacterial agent for the heating system was added to the raw materials of the antibacterial heating material, while the other raw materials and dosages were the same as those in Example 1.

[0048] Comparative Example 4 The antibacterial heat patch of Comparative Example 4 was prepared in the same way as that of Example 1, except that the antibacterial heat-generating material raw material did not contain antibacterial microcapsules of the heating system, while the other raw materials and dosages were the same as those of Example 1.

[0049] Performance Testing (Part 1) The antibacterial heat patch and antibacterial meltblown fabric obtained in different Examples 1 and Comparative Example 1 were tested using the following methods. The test results are shown in Table 6.

[0050] Antibacterial rate: The antibacterial meltblown fabric was placed at temperatures of 40℃, 50℃, and 65℃, with humidity controlled at 85%. The antibacterial rate was tested according to GB / T 20944.3-2008 "Evaluation of Antibacterial Properties of Fabrics Part 3: Shaking Method". The sample and control sample (pure cotton) were cut into 5×5mm fragments, and 0.75g of each was added to 70ml of 0.03mol / mL PBS buffer. Escherichia coli bacterial suspension was added, and the antibacterial rate was tested after shaking for 18h. Y = (Wt - Qt) / Wt, where Wt is the viable bacterial concentration (CFU / mL) of the control sample after 18h treatment; Qt is the viable bacterial concentration (CFU / mL) of the test sample after 18h treatment. The meltblown fabrics prepared in Example 1 and Comparative Example 1 were designed as three groups of samples, and the antibacterial rate was the mean of the three groups.

[0051] Table 6 Performance test results of antibacterial meltblown fabric

[0052] The test results in Table 6 show that the meltblown fabric obtained in this application has the highest antibacterial rate of 98.9%, 99.2% and 99.4% at 40℃ / 85%RH, 50℃ / 85%RH and 65℃ / 85%RH, respectively. The obtained meltblown fabric has high antibacterial properties and meets the antibacterial requirements of the high temperature and humid environment for use in heat packs.

[0053] Based on the data of various indicators of meltblown fabric in Comparative Example 1 and Example 1, it was found that the present application adds compound antibacterial agent to meltblown fabric raw material, which makes meltblown fabric have high antibacterial properties.

[0054] Performance Testing (Part 2) The antibacterial properties of the heat patches obtained in different Examples 1-12 and Comparative Examples 1-4 were tested using the following methods. The test results are shown in Table 7.

[0055] Inhibition rate: The Escherichia coli suspension was diluted to 1.0 × 10⁻⁶. 6 CFU / mL, take 0.02mL of diluted bacterial solution and spread it evenly on the surface of a 1cm×1cm bacterial carrier. Use sterile forceps to pick up the bacterial carrier, with the bacterial side facing down, and accurately apply it to the center of the heat patch. Use sterile high-temperature resistant medical tape to fix it. Tear off the gelatin layer of the heat patch and attach the heat patch to the silicone simulated skin surface, ensuring no air bubbles and complete adhesion. Place it in a constant temperature and humidity chamber at 25℃ / 60%RH for 4h and 8h and observe the colony count to calculate the antibacterial rate.

[0056] Table 7 Performance test results of antibacterial heat packs

[0057] The test results in Table 7 show that the antibacterial rates of the heat patch obtained in this application can reach 99.8% and 99.9% at 4h and 8h respectively, which have high antibacterial properties. Moreover, the antibacterial effect is basically synchronized with the heating duration of the heat patch, which can achieve full protection during the use of the heat patch.

[0058] The antibacterial performance tests of the heat packs in Examples 1-4 revealed that the antibacterial rates of the heat pack in Example 3 were 99.5% and 99.7% at 4 hours and 8 hours, respectively, both higher than those in Examples 1-2 and Example 4. This indicates that a mass ratio of 2:3:5 for antibacterial microcapsules A, B, and C in the heating system of the antibacterial heating material is more suitable, which can further improve the antibacterial properties of the heat pack and ensure continuous output of antibacterial components throughout the entire heating period of the heat pack.

[0059] The antibacterial performance tests of the heat packs in Examples 3 and 5-8 revealed that the antibacterial rates of the heat packs in Examples 5-7 were 99.6% and 99.8% after 4 hours and 8 hours, respectively, both higher than those in Examples 3 and 8. This indicates that a weight ratio of cymene to carvacrol in the antibacterial agent of the heating system of 1:(2-4) is more suitable, which improves the antibacterial properties of the heat pack and ensures continuous output of antibacterial components throughout the entire heating period of the heat pack. This shows that antibacterial components such as cymene and carvacrol will automatically release gaseous molecules as the temperature rises, and the antibacterial effect is basically synchronized with the heating duration of the heat pack, achieving full protection during the use of the heat pack.

[0060] The antibacterial performance tests of the heat packs in Examples 6 and 9-12 revealed that the antibacterial rates of the heat packs in Examples 9-11 at 4h and 8h were 99.7-99.8% and 99.9%, respectively, both higher than those in Examples 6 and 12. This indicates that a weight ratio of chitosan quaternary ammonium salt to silane coupling agent of 1:(1.5-2.5) in the antibacterial agent of the heating system in the preparation of antibacterial heating materials is more suitable and can further improve the antibacterial properties of the heat packs.

[0061] Based on the data of various indicators of the heat packs in Comparative Examples 1-4 and Example 1, it was found that adding compound antibacterial agents to the meltblown fabric raw material and adding antibacterial agents and antibacterial microcapsules of the heating system to the antibacterial heating material raw material can improve the antibacterial properties of the heat pack to varying degrees and prolong the antibacterial effect of the heat pack.

[0062] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A safe antibacterial heat patch with stable heating, characterized in that, The heat-stable, safe antibacterial heat patch includes a gelatin layer, a non-woven bag made of antibacterial meltblown fabric, and an antibacterial heat-generating material filled inside the non-woven bag. The gelatin layer is adhered to the surface of the non-woven bag. Based on the total mass of the antibacterial meltblown fabric, the antibacterial meltblown fabric comprises the following raw materials in parts by weight: 90-100 parts of meltblown polypropylene masterbatch and 1-10 parts of compound antibacterial agent; Based on the total mass of the compound antibacterial agent, the compound antibacterial agent comprises the following raw materials in parts by weight: 25-30 parts of nano silver ion antibacterial agent, 20-25 parts of nano zinc oxide, 15-20 parts of anatase nano titanium dioxide, and 4-6 parts of magnesium stearate. The raw materials of the antibacterial heating material contain heating system antibacterial agents and heating system antibacterial microcapsules; the heating system antibacterial microcapsules are quaternary ammonium salt antibacterial agents with a surface coating of hot-melt material.

2. The heat-stable, safe, antibacterial heating patch according to claim 1, characterized in that, Based on the total mass of the antibacterial heating material, the antibacterial heating material comprises the following raw materials in parts by weight: 40-60 parts iron powder, 4-8 parts vermiculite, 10-20 parts activated carbon powder, 3-5 parts antibacterial agent for the heating system, 2-3 parts antibacterial microcapsules for the heating system, 1-3 parts inorganic salt, and 70-100 parts water.

3. The heat-stable, safe, antibacterial heating patch according to claim 2, characterized in that, The antibacterial microcapsules of the heating system are prepared through the following steps: S1. Heat the hot-melt material PEG-1000 until it is completely melted, add the quaternary ammonium salt antibacterial agent, stir, and get the mixture A. Pour the mixture A into deionized water at 25°C and stir continuously to get antibacterial microcapsules A. S2. Heat the hot-melt material PEG-1500 until it is completely melted, add the quaternary ammonium salt antibacterial agent, stir, and get the mixture B. Pour the mixture B into deionized water at 25°C and stir continuously to get the antibacterial microcapsules B. S3. Heat the hot-melt material PEG-2000 until it is completely melted, add the quaternary ammonium salt antibacterial agent, stir, and obtain a mixture C. Pour the mixture C into deionized water at 25°C and stir continuously to obtain antibacterial microcapsules C. S4. Mix antibacterial microcapsules A, B and C in proportion, dry them, and obtain the heating system antibacterial microcapsules. The heat-melting material is PEG of different molecular weights. The heat-melting material used in antibacterial microcapsule A is PEG-1000, the heat-melting material used in antibacterial microcapsule B is PEG-1500, and the heat-melting material used in antibacterial microcapsule C is PEG-2000.

4. The safe antibacterial heat patch with stable heating according to claim 3, characterized in that, The mass ratio of the antibacterial microcapsules A, B, and C is 2:3:

5.

5. The heat-stable, safe, antibacterial heating patch according to claim 2, characterized in that, Based on the total mass of the antibacterial agent in the heating system, the antibacterial agent in the heating system comprises the following raw materials in parts by weight: 4-8 parts of nano silver ion antibacterial agent, 4-6 parts of nano zinc oxide, 3-5 parts of nano copper oxide, 1-2 parts of nano tourmaline powder, 3-5 parts of carvacrol, 1-3 parts of p-cymene, 1-1.5 parts of silane coupling agent, and 0.5-1 parts of chitosan quaternary ammonium salt.

6. The heat-stable, safe, antibacterial heating patch according to claim 5, characterized in that, The weight ratio of p-cymene to carvacrol is 1:(2-4).

7. The heat-stable, safe, antibacterial heating patch according to claim 5, characterized in that, The weight ratio of the chitosan quaternary ammonium salt to the silane coupling agent is 1:(1.5-2.5).

8. A method for preparing a heat-stable, safe, antibacterial heat patch according to any one of claims 1-7, characterized in that, The following steps are included: S1. Add compound antibacterial agent to meltblown polypropylene masterbatch to prepare antibacterial meltblown fabric; S2. Mix all the raw materials of the antibacterial heating material evenly, put them into a non-woven bag, seal them by heat pressing, attach the gelatin layer and the covering layer, and seal the whole thing to obtain a safe antibacterial heat patch with stable heating.

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