A composition for the treatment of dandruff and its use

Abstract

The present application provides a kind of anti-dandruff composition and its application, the anti-dandruff composition includes sclareolide, climbazole, beta-glucan and phenoxyethanol.The present application creatively finds that sclareolide, climbazole, beta-glucan and phenoxyethanol have synergistic effect, not only can effectively clean grease and dirt on the scalp and hair, have conditioning effect, while taking into account the mild anti-dandruff performance, long-term use can improve the stability of scalp barrier.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical technology, specifically relating to an anti-dandruff composition and its application. Background Technology

[0002] CN107961212A discloses an oil-controlling and antibacterial shampoo, comprising the following components in parts by weight: 22-28 parts conditioning agent, 2-8 parts citric acid, 0.5-2 parts Bacillus subtilis, 1-4 parts lauramidopropyl betaine, 21-31 parts cocoyl diethanolamine, 2-7 parts methylparaben, 0.5-2 parts methylchloroisothiazolinone, 2-6 parts antibacterial and antipruritic agent, 2-5 parts dried ginger, 2-6 parts guar gum hydroxypropyltrimethylammonium chloride, and 0.8-2.3 parts ethyl butyrate; wherein the antibacterial and antipruritic agent comprises a mixture of ketoconazole, selenium disulfide, and clomiphene citrate.

[0003] CN114917135A discloses a shampoo based on salicylic acid and sulfur, comprising the following components: solvent, pH adjuster, anti-dandruff agent, moisturizer, binder, cooling agent, fragrance, chelating agent, thickener mixture, surfactant mixture, hair conditioning agent mixture, and preservative mixture. The anti-dandruff agent is salicylic acid, and the hair conditioning agent contains sulfur.

[0004] Current shampoos generally achieve their claimed dandruff-removing effects by adding traditional chemical ingredients with strong anti-dandruff activity. These mainly include powerful bactericides such as selenium sulfide, ketoconazole, zinc pyrithione, and salicylic acid. These ingredients exfoliate the scalp, disrupting the scalp's microecological balance, leading to dryness, sensitivity, and even increased itching with repeated washing—treating the symptoms but not the root cause. Popular online remedies using broad-spectrum bactericidal agents like sulfur or iodine are far more harmful than beneficial, disrupting the scalp's pH balance and natural barrier, causing strong irritation, and posing a risk of staining. Furthermore, commercially available shampoos containing relatively mild anti-dandruff ingredients like piroctone olamine salts can also easily disrupt the scalp's microbiome balance with long-term, frequent use. Some products add prebiotics and specific plant extracts to regulate the scalp's microecological balance, promoting beneficial bacteria and inhibiting harmful bacteria. However, this technology is technologically advanced, with issues such as activity preservation and transdermal delivery; the raw materials are expensive, and many are added only as conceptual ingredients with minimal effect.

[0005] In general, current dandruff removal technology is developing towards greater precision and gentleness, but there is still no shampoo that can effectively and gently remove dandruff, be used long-term without sacrificing scalp health, and repair the scalp barrier and regulate the scalp microecology. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the purpose of this invention is to provide an anti-dandruff composition and its application. This invention creatively discovers that styracil lactone, clomiphene, β-glucan and phenoxyethanol have a synergistic effect, which can gently remove dandruff and maintain the stability of the scalp barrier.

[0007] To achieve this objective, the present invention adopts the following technical solution: In a first aspect, the present invention provides an anti-dandruff composition comprising styracil lactone, clomiphene citrate, β-glucan, and phenoxyethanol.

[0008] Perilla lactone is derived from the natural plant cudweed, with a well-defined structure. It can not only reduce sticky and loose dandruff, but also stabilize and soothe the scalp, and reduce erythema and itching. Clomid can effectively remove dandruff, relieve itching and control oil. β-glucan has good repairing and moisturizing effects. Phenoxyethanol can help inhibit microorganisms on the scalp surface, indirectly reducing dandruff and itching caused by bacterial imbalance.

[0009] This invention creatively discovers that succinyl perilla lactone, clomiphene, β-glucan, and phenoxyethanol have a synergistic effect, which can not only effectively clean the oil and dirt on the scalp and hair and have a conditioning effect, but also take into account the gentle dandruff removal performance. Long-term use can improve the stability of the scalp barrier.

[0010] Preferably, the anti-dandruff composition comprises, by weight, 0.05-1 parts of styrax lactone, 0.02-0.4 parts of clomiphene, 0.05-1 parts of β-glucan and 0.02-0.4 parts of phenoxyethanol.

[0011] The weight parts of the sage lactone can be 0.05 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, or 1 part, etc.

[0012] The weight parts of the clomibazole can be 0.02 parts, 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, or 0.4 parts, etc.

[0013] The weight parts of the β-glucan can be 0.05 parts, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, or 1 part, etc.

[0014] The phenoxyethanol can be present in parts by weight of 0.02, 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, or 0.4 parts, etc.

[0015] In a second aspect, the present invention provides the use of the anti-dandruff composition as described in the first aspect in the preparation of hair cosmetics.

[0016] Preferably, the hair cosmetic includes any one of shampoo, conditioner, hair oil, or hair mask.

[0017] Preferably, the content of the anti-dandruff composition in the hair cosmetic is 0.1~10wt%, for example, it can be 0.1wt%, 0.5wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, or 10wt%.

[0018] Preferably, the hair cosmetic further includes any one or a combination of at least two of the following: surfactants, hair conditioning agents, emulsifying stabilizers, pH adjusters, antioxidants, moisturizers, emulsifiers, thickeners, fragrances, preservatives, or solvents.

[0019] Thirdly, the present invention provides an anti-dandruff shampoo, wherein the anti-dandruff shampoo comprises, by weight, 0.1 to 10 parts of the anti-dandruff composition as described in the first aspect, 30 to 60 parts of surfactant, 0.01 to 2 parts of hair conditioning agent, 0.2 to 1 part of emulsifying stabilizer, 0.1 to 0.5 parts of pH adjuster and 25 to 70 parts of solvent.

[0020] The weight parts of the dandruff-removing composition can be 0.1 parts, 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, or 10 parts, etc.

[0021] The surfactant can be present in parts by weight of 30, 35, 40, 45, 50, 55, or 60 parts, etc.

[0022] The hair conditioning agent can be present in weight parts of 0.01, 0.1, 0.2, 0.5, 0.7, 1, 1.3, 1.5, 1.8, or 2 parts, etc.

[0023] The emulsifying stabilizer can be present in parts by weight of 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1 part, etc.

[0024] The pH adjuster can be present in weight parts of 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, or 0.5, etc.

[0025] The solvent can be in parts by weight of 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70 parts, etc.

[0026] The anti-dandruff shampoo provided by this invention meets all the standards of commercially available shampoos, has superior cleansing, foaming and smoothing properties, significantly inhibits Malassezia furfur, gently removes dandruff, and can improve the stability of the scalp barrier with long-term use.

[0027] Preferably, the surfactant comprises any one or a combination of at least two of sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoaminopropionate, lauryl hydroxysulfonate betaine, or cocoyl monoethanolamine.

[0028] Preferably, the surfactant includes sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoaminopropionate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine.

[0029] In this invention, sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine have a synergistic effect, which synergistically improves the various properties of the shampoo.

[0030] Preferably, the mass ratio of sodium methyl cocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, lauryl hydroxysulfonate betaine and cocoyl monoethanolamine is (12~15):(10~13):(5~10):(5~10):(1~3).

[0031] The specific point values ​​in (12~15) can be 12, 12.5, 13, 13.5, 14, 14.5 or 15, etc.

[0032] The specific point values ​​in (10~13) can be 10, 10.2, 10.5, 10.7, 11, 11.3, 11.5, 11.8, 12, 12.5, 13, etc.

[0033] The specific point values ​​in the first (5~10) can be 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5 or 10, etc.

[0034] The specific point values ​​in the first (5~10) can be 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5 or 10, etc.

[0035] The specific point values ​​in (1~3) can be 1, 1.2, 1.5, 1.7, 2, 2.3, 2.5, 2.8 or 3, etc.

[0036] Preferably, the hair conditioning agent includes any one or a combination of at least two of polyquaternium-10, lauryl dimethylammonium hydroxypropyl hydrolyzed keratin, coconut oil, or sunflower seed oil.

[0037] Preferably, the emulsifying stabilizer comprises any one or a combination of at least two of sodium chloride, styrene / acrylate copolymers, or cocoyl glucoside.

[0038] Preferably, the pH adjuster comprises any one or a combination of at least two of citric acid monohydrate, lactic acid, potassium hydroxide, or sodium hydroxide.

[0039] Preferably, the solvent comprises a polyol and / or water.

[0040] Preferably, the polyol includes any one or a combination of at least two of the following: decanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, or dipropylene glycol.

[0041] Fourthly, the present invention provides a method for preparing an anti-dandruff shampoo as described in the third aspect, the method comprising: A pH adjuster, solvent, and surfactant are mixed, and then homogenized with a hair conditioning agent, an emulsion stabilizer, and an anti-dandruff composition as described in the first aspect to obtain the anti-dandruff shampoo.

[0042] Preferably, the mixing temperature is 80~90℃, for example, it can be 80℃, 81℃, 82℃, 83℃, 84℃, 85℃, 86℃, 87℃, 88℃, 89℃ or 90℃, etc.

[0043] Preferably, the mixing speed is 1000~2000 rpm, for example, it can be 1000 rpm, 1100 rpm, 1200 rpm, 1300 rpm, 1400 rpm, 1500 rpm, 1600 rpm, 1700 rpm, 1800 rpm, 1900 rpm or 2000 rpm, etc.

[0044] Preferably, the mixing time is 10 to 30 minutes, for example, 10 minutes, 12 minutes, 15 minutes, 17 minutes, 20 minutes, 23 minutes, 25 minutes, 28 minutes or 30 minutes.

[0045] Preferably, the homogenization temperature is 40~50℃, for example, it can be 40℃, 41℃, 42℃, 43℃, 44℃, 45℃, 46℃, 47℃, 48℃, 49℃ or 50℃, etc.

[0046] Preferably, the rotational speed of the homogenizer is 1000~3000 rpm, for example, it can be 1000 rpm, 1200 rpm, 1500 rpm, 1700 rpm, 2000 rpm, 2300 rpm, 2500 rpm, 2800 rpm or 3000 rpm, etc.

[0047] Preferably, the homogenization time is 5 to 15 minutes, for example, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 11 minutes, 12 minutes, 13 minutes, 14 minutes or 15 minutes.

[0048] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0049] Compared with the prior art, the present invention has the following beneficial effects: This invention creatively discovers that styracil lactone, clomiphene, β-glucan, and phenoxyethanol have a synergistic effect. The shampoo prepared by this combination meets the standards of commercially available shampoos in all aspects, and has superior cleansing, foaming, and smoothing properties. It significantly inhibits Malassezia furfur, gently removes dandruff, and can improve the stability of the scalp barrier with long-term use. Attached Figure Description

[0050] Figure 1 The flocculation curves are for the anti-dandruff shampoo and commercially available shampoo products provided in Examples 1-3 and Comparative Example 5. Detailed Implementation

[0051] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0052] Where specific techniques or conditions are not specified in the examples, they shall be performed in accordance with the techniques or conditions described in the literature in this field, or in accordance with the product instructions. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased through legitimate channels.

[0053] The sources of materials used in the following specific embodiments are as follows: Example 1 This embodiment provides an anti-dandruff shampoo, which comprises the following components by weight: The preparation method includes: heating the pH adjuster, solvent and surfactant to 85°C, mixing at 1500 rpm for 20 min; cooling to 45°C, adding hair conditioning agent, emulsifying stabilizer and anti-dandruff composition, homogenizing at 2000 rpm for 10 min, and obtaining the product.

[0054] Example 2 This embodiment provides an anti-dandruff shampoo, which comprises the following components by weight: The preparation method includes: heating the pH adjuster, solvent and surfactant to 80°C, mixing at 2000 rpm for 10 min; cooling to 50°C, adding hair conditioning agent, emulsifying stabilizer and anti-dandruff composition, homogenizing at 1000 rpm for 15 min, and obtaining the product.

[0055] Example 3 This embodiment provides an anti-dandruff shampoo, which comprises the following components by weight: The preparation method includes: heating the pH adjuster, solvent and surfactant to 90°C, mixing at 1000 rpm for 30 min; cooling to 40°C, adding hair conditioning agent, emulsifying stabilizer and anti-dandruff composition, homogenizing at 3000 rpm for 5 min, and obtaining the product.

[0056] Example 4 This embodiment provides an anti-dandruff shampoo, which differs from Embodiment 1 only in that: sodium methyl cocoyl taurate is not added to the surfactant, and its reduced amount is proportionally allocated to sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine, while the remaining raw materials remain unchanged.

[0057] Example 5 This embodiment provides an anti-dandruff shampoo, which differs from Embodiment 1 only in that: sodium C14-16 olefin sulfonate is not added to the surfactant, and its reduced amount is proportionally allocated to sodium methyl cocoyl taurate, sodium cocoyl aminopropionate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine, while the remaining raw materials remain unchanged.

[0058] Example 6 This embodiment provides an anti-dandruff shampoo, which differs from Embodiment 1 only in that: sodium cocoaminopropionate is not added to the surfactant, and its reduced amount is proportionally allocated to sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine, while the remaining raw materials remain unchanged.

[0059] Example 7 This embodiment provides an anti-dandruff shampoo, which differs from Embodiment 1 only in that: lauryl hydroxysulfonate is not added to the surfactant, and its reduced amount is proportionally allocated to sodium methyl cocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, and cocoyl monoethanolamine, while the remaining raw materials remain unchanged.

[0060] Example 8 This embodiment provides an anti-dandruff shampoo, which differs from Embodiment 1 only in that: no cocoyl monoethanolamine is added to the surfactant, and its reduced amount is proportionally allocated to sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, and lauryl hydroxysulfonate betaine, while the remaining raw materials remain unchanged.

[0061] Comparative Example 1 This comparative example provides an anti-dandruff shampoo, which differs from Example 1 only in that: no styracil lactone is added to the anti-dandruff composition, and its reduced amount is allocated proportionally to clomiphene, β-glucan, and phenoxyethanol, while the remaining raw materials remain unchanged.

[0062] Comparative Example 2 This comparative example provides an anti-dandruff shampoo, which differs from Example 1 only in that: clomiphene citrate is not added to the anti-dandruff composition, and its reduced amount is allocated proportionally to styracil lactone, β-glucan, and phenoxyethanol, while the remaining raw materials remain unchanged.

[0063] Comparative Example 3 This comparative example provides an anti-dandruff shampoo, which differs from Example 1 only in that: β-glucan is not added to the anti-dandruff composition, and its reduced amount is allocated proportionally to styracil lactone, clomiphene, and phenoxyethanol, while the remaining raw materials remain unchanged.

[0064] Comparative Example 4 This comparative example provides an anti-dandruff shampoo, which differs from Example 1 only in that: phenoxyethanol is not added to the anti-dandruff composition, and its reduced amount is allocated proportionally to styracil lactone, clomiphene, and β-glucan, while the remaining raw materials remain unchanged.

[0065] Comparative Example 5 This comparative example provides an anti-dandruff shampoo, which differs from Example 1 only in that: no anti-dandruff composition is added, the reduction is made up by piroctone ethanolamine salt, and all other ingredients remain unchanged.

[0066] Test Example 1 During shampooing, the shampoo is diluted, causing the anionic surfactant and cationic polymer to dissociate. This leads to a decrease in the apparent charge of the cationic polymer, resulting in phase separation and precipitation from the system, forming flocculation. The resulting flocculent material promotes the deposition of conditioning oils onto the hair surface. Therefore, flocculation experiments can characterize the smoothness of hair; the lower the light transmittance, the smoother the hair.

[0067] Examples 1-3 and Comparative Example 5, specifically the anti-dandruff shampoo and a commercially available product (Schwarzkopf Amino Acid Revitalizing Repair Shampoo), were serially diluted with deionized water at volume ratios of 1:1 to 1:100 to prepare shampoo aqueous solutions. The solution was calibrated to zero using deionized water to ensure no air bubbles were present in the test sample. The transmittance of the shampoo aqueous solution at 600 nm was recorded using a UV spectrophotometer, and a curve was plotted as a function of dilution factor and transmittance.

[0068] The flocculation curve of the shampoo is as follows Figure 1 As shown, the dandruff shampoo provided by the present invention has a flocculation effect comparable to commercially available shampoos and exhibits excellent smoothing properties during rinsing.

[0069] Test Example 2 By simulating the mechanical action in actual use, the shampoo sample solution was made to produce foam, and the foam volume at different time points was measured to evaluate the product's instant foaming ability and foam stability.

[0070] The anti-dandruff shampoos provided in Examples 1-8 and Comparative Example 5, as well as the commercially available product (Schwarzkopf Amino Acid Revitalizing Repair Shampoo), were diluted to 1 vol% aqueous solutions using 150 ppm hard water (simulating actual water quality). The solutions were then incubated in a 40°C constant temperature water bath for 30 minutes to ensure the test temperature closely approximates the water temperature used for human shampooing. 50 mL of the incubated test sample solution was poured into a clean 250 mL stoppered graduated cylinder, shaken vertically 10 times, and immediately placed on the experimental table. A stopwatch was started. At the instant the timing began (0 seconds), the total volume of the foam layer was read and recorded as test number 1. Subsequently, the total volume of the foam layer was read and recorded again at fixed time points (minutes 1, 2, 3, 4, 5, and 6), recorded as test numbers 2-7. The entire observation period was 6 minutes to assess foam decay. Each sample was tested in triplicate, and the final result was the average value to ensure data reliability.

[0071] The test results are shown in Table 1. The foam height and foam stability of the anti-dandruff shampoo of this invention meet the standards of commercially available shampoos, exhibiting superior foam richness and excellent cleaning and foaming performance. As demonstrated in Examples 4-8, sodium methyl cocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine have a synergistic effect, synergistically enhancing the shampoo's immediate foaming ability and foam stability.

[0072] Table 1 Test Example 3 Malassezia furfur (ATCC 44344) was prepared into 1×10 5The CFU bacterial suspension was evenly spread onto Leeming & Notman agar plates and dried in a sterile operating table. The anti-dandruff shampoos provided in Examples 1-3 and Comparative Examples 1-5, and a commercially available product (Schwarzkopf Amino Acid Revitalizing Repair Shampoo) were diluted to 50 vol% aqueous solutions. 20 μL of the shampoo solution was quantitatively added to the above plates and incubated at 30°C for 72 h. The diameter of the inhibition zone was recorded. Each sample was tested in triplicate, and the final result was the average value to ensure data reliability.

[0073] The test results are shown in Table 2. The anti-dandruff shampoo of this invention has a good inhibitory effect on Malassezia furfur, effectively removing dandruff and relieving itching. Comparative Examples 1-4 show that styracil lactone, clomiphene citrate, β-glucan, and phenoxyethanol have a synergistic effect.

[0074] Table 2 Test Example 4 The subjects were healthy men and women aged 18-60 years with hair length of 5-40 cm, damaged scalp barrier, and prone to oiliness. They had not undergone any special hair styling treatments such as dyeing, perming, or styling within the past month, and their hair was not dyed or permed during the test period. They were divided into groups of 10, using the anti-dandruff shampoo provided in Examples 1-3 and Comparative Examples 1-5, or a commercially available product (Schwarzkopf Amino Acid Revitalizing Repair Shampoo), and used the shampoo once daily. The scalp skin stratum corneum moisture content (higher values ​​indicate higher skin moisture content) and scalp skin transepidermal water loss (lower values ​​indicate better skin barrier function) were measured using an instrument probe. The rate of change of each indicator compared to before use was calculated after 28 and 56 days of continuous shampoo use.

[0075] The test results are shown in Table 3. The anti-dandruff shampoo provided by this invention showed less transepidermal water loss in the scalp after 28 and 56 days of continuous use, and a significant increase in the moisture content of the scalp's stratum corneum. Long-term use can repair the scalp skin barrier. Comparative Examples 1-4 show that perilla lactone, clomiphene, β-glucan, and phenoxyethanol have a synergistic effect.

[0076] Table 3 This invention illustrates an anti-dandruff composition and its application through the above embodiments. However, this invention is not limited to the above embodiments, meaning that this invention does not necessarily rely on the above embodiments for implementation. Those skilled in the art should understand that any improvements to this invention, equivalent substitutions of the raw materials in the product, addition of auxiliary components, and selection of specific methods, all fall within the protection and disclosure scope of this invention.

[0077] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0078] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. An anti-dandruff composition, characterized in that, The anti-dandruff composition includes perilla lactone, clomiphene, β-glucan, and phenoxyethanol.

2. The anti-dandruff composition according to claim 1, characterized in that, The anti-dandruff composition comprises, by weight, 0.05-1 part of perillaldehyde, 0.02-0.4 parts of clomiphene, 0.05-1 part of β-glucan and 0.02-0.4 parts of phenoxyethanol.

3. The use of the anti-dandruff composition according to claim 1 or 2 in the preparation of hair cosmetics.

4. The application according to claim 3, characterized in that, The hair cosmetics include any one of shampoo, conditioner, hair oil or hair mask; Preferably, the anti-dandruff composition is present in the hair cosmetic at a concentration of 0.1-10 wt%. Preferably, the hair cosmetic further includes any one or a combination of at least two of the following: surfactants, hair conditioning agents, emulsifying stabilizers, pH adjusters, antioxidants, moisturizers, emulsifiers, thickeners, fragrances, preservatives, or solvents.

5. An anti-dandruff shampoo, characterized in that, The anti-dandruff shampoo comprises, by weight, 0.1-10 parts of the anti-dandruff composition as described in claim 1 or 2, 30-60 parts of surfactant, 0.01-2 parts of hair conditioning agent, 0.2-1 parts of emulsifying stabilizer, 0.1-0.5 parts of pH adjuster, and 25-70 parts of solvent.

6. The anti-dandruff shampoo according to claim 5, characterized in that, The surfactant includes any one or a combination of at least two of the following: sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoaminopropionate, lauryl hydroxysulfonate betaine, or cocoyl monoethanolamine. Preferably, the surfactant includes sodium methylcocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoylaminopropionate, lauryl hydroxysulfonate betaine, and cocoyl monoethanolamine; Preferably, the mass ratio of sodium methyl cocoyl taurate, sodium C14-16 olefin sulfonate, sodium cocoyl aminopropionate, lauryl hydroxysulfonate betaine and cocoyl monoethanolamine is (12~15):(10~13):(5~10):(5~10):(1~3).

7. The anti-dandruff shampoo according to claim 5 or 6, characterized in that, The hair conditioning agent includes any one or a combination of at least two of the following: polyquaternium-10, lauryl dimethylammonium hydroxypropyl hydrolyzed keratin, coconut oil, or sunflower seed oil; Preferably, the emulsifying stabilizer comprises any one or a combination of at least two of sodium chloride, styrene / acrylate copolymer, or cocoyl glucoside; Preferably, the pH adjuster comprises any one or a combination of at least two of citric acid monohydrate, lactic acid, potassium hydroxide, or sodium hydroxide; Preferably, the solvent comprises a polyol and / or water; Preferably, the polyol includes any one or a combination of at least two of the following: decanediol, 1,2-butanediol, 1,2-pentanediol, 1,2-hexanediol, or dipropylene glycol.

8. The method for preparing the anti-dandruff shampoo according to any one of claims 5 to 7, characterized in that, The preparation method includes: A pH adjuster, solvent, and surfactant are mixed, and then homogenized with a hair conditioning agent, an emulsion stabilizer, and the anti-dandruff composition according to claim 1 or 2 to obtain the anti-dandruff shampoo.

9. The preparation method according to claim 8, characterized in that, The mixing temperature is 80~90℃; Preferably, the mixing speed is 1000~2000 rpm; Preferably, the mixing time is 10 to 30 minutes.

10. The preparation method according to claim 8 or 9, characterized in that, The homogenization temperature is 40~50℃; Preferably, the rotational speed of the homogenizer is 1000~3000 rpm; Preferably, the homogenization time is 5 to 15 minutes.

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