Mild antidandruff composition of selenium disulfide, a cosmetic and a method of preparation

Abstract

The application relates to the technical field of cosmetics, and particularly discloses a mild selenium disulfide anti-dandruff composition, a cosmetic and a preparation method thereof. The mild selenium disulfide anti-dandruff composition comprises the following components: selenium disulfide, a plant extract combination, a polypeptide combination, a saccharide isomerate combination and a polyquaternium salt combination; the plant extract combination comprises radix sophorae flavescentis extract, radix angelicae sinensis extract and biota leaf extract. The mild selenium disulfide anti-dandruff composition has the advantages that flavonoids and polyphenol substances rich in the radix sophorae flavescentis extract, the radix angelicae sinensis extract and the biota leaf extract are combined with polypeptides to form flavonoid-polypeptide complexes, and the saccharide isomerate and the polyquaternium salt are synergistically combined to repel excessive deposition of the selenium disulfide; therefore, the complexes have stronger affinity on the scalp surface than free selenium disulfide, are preferentially adsorbed on the scalp cuticle, form a competitive binding barrier and weaken stimulation.

Description

Technical Field

[0001] This application relates to the field of cosmetic technology, and more specifically, to a mild anti-dandruff composition of selenium disulfide, a cosmetic product, and a method for preparing the same. Background Technology

[0002] With the fast pace of modern life, irregular schedules, and increased exposure to environmental pollutants, scalp health problems are becoming more common and diverse. Dandruff, itchy scalp, sensitive scalp, and dry, brittle hair have become core pain points for many consumers. Consumers' demands for shampoos have evolved from traditional, single-function cleansing to a more diversified and high-quality demand for "effective dandruff removal, gentle repair, and synergistic hair conditioning," placing higher demands on product efficacy, gentleness, stability, and user experience. However, currently available anti-dandruff shampoos still generally suffer from numerous technical bottlenecks and defects, failing to meet consumers' core needs.

[0003] Selenium disulfide, as a highly effective and broad-spectrum antifungal ingredient, has excellent inhibitory effects on Malassezia and is currently recognized as one of the core active ingredients for dandruff control in the anti-dandruff shampoo industry. However, selenium disulfide is highly irritating and can easily damage the scalp's stratum corneum structure, leading to dryness, tightness, and redness. Long-term use can damage the scalp barrier function and is not suitable for people with sensitive scalps, seborrheic scalps, or other fragile scalps.

[0004] Currently, the following methods are commonly used to improve the irritation problem of selenium disulfide, but the results are unsatisfactory: 1) Adding soothing and repairing ingredients: By combining bisabolol, ceramides, panthenol, and plant extracts, this method can exert anti-inflammatory and barrier-repairing effects after the irritation occurs. However, selenium sulfide irritates the scalp due to its "keratolytic" mechanism, which occurs immediately during shampooing. Soothing ingredients intervene after the irritation occurs and cannot block it at the source.

[0005] 2) Polymer encapsulation / microencapsulation: Selenium disulfide is encapsulated using chitosan quaternary ammonium salt, starch microcapsules, and wax. While this method reduces the contact between selenium disulfide and the scalp and hair, thus minimizing irritation, the encapsulation layer not only isolates the scalp but also hinders the contact between selenium disulfide and Malassezia, leading to a decrease in dandruff-reducing effectiveness. Summary of the Invention

[0006] To address the technical problem that selenium disulfide anti-dandruff products are highly irritating and existing improvement solutions are ineffective, this application provides a mild anti-dandruff composition of selenium disulfide, a cosmetic product, and a method for preparing the same.

[0007] In a first aspect, this application provides a mild anti-dandruff composition of selenium disulfide, employing the following technical solution: A mild anti-dandruff composition of selenium disulfide, comprising the following components: Selenium disulfide, Plant extract combination polypeptide combination, Assemblance of carbohydrate isomers Polyquaternium salt combinations; The combination of plant extracts includes: Sophora angstinica root extract, Angelica polymorha sinensis root extract, and Platycladus orientalis leaf extract.

[0008] By employing the above technical solution: the irritant properties of selenium disulfide arise from its ability to promote keratin exfoliation (keratinization) on the scalp surface, weakening the scalp barrier, exposing nerve endings, and causing irritation. The solution in this application is based on the following two points: With the help of Sophora angsufola root extract, Angelica polymorpha sinensis root extract, and Biotah orientalis leaf extract, the flavonoids and polyphenols rich in these three ingredients can form hydrogen bonds with the amide groups of polypeptides through their phenolic hydroxyl groups. At the same time, the hydrophobic ring structure of flavonoids / polyphenols can interact with the hydrophobic side chains of polypeptides to form a weakly bound complex. 2. By covalently binding one end of the glycosyl isomer to the ε-amino group of lysine in hair keratin and binding the other end to polyquaternium salt via hydrogen bonding / electrostatic interaction, the polyquaternium salt is stably anchored to the hair surface. Firstly, this changes the hair surface from hydrophobic to hydrophilic, reducing the adsorption of hydrophobic selenium disulfide particles. Secondly, its positive charge generates electrostatic repulsion with the selenium disulfide particles (which have a negative charge on their surface), thereby reducing the excessive deposition of selenium disulfide.

[0009] Compared with "free selenium disulfide", "flavonoid-peptide complex" has a stronger affinity on the scalp surface, thus preferentially adsorbing onto the scalp stratum corneum and forming a competitive binding barrier between selenium disulfide and the scalp, thereby reducing the direct deposition and contact of selenium disulfide on the scalp.

[0010] Optionally, the polypeptide combination includes myristoyl pentapeptide-4, acetyl tetrapeptide-3, hexapeptide-3, and palmitoyl tripeptide-1.

[0011] Optionally, the plant extract combination is a mixture of water, butylene glycol, Sophora flavescens root extract, Angelica sinensis root extract, Platycladus orientalis leaf extract, 1,2-hexanediol and p-hydroxyacetophenone. The polypeptide combination is a mixture of glycerol, water, myristoyl pentapeptide-4, acetyl tetrapeptide-3, hexapeptide-3 and palmitoyl tripeptide-1; The carbohydrate isomer combination is a mixture of carbohydrate isomers, water, citric acid, and sodium citrate; The polyquaternary ammonium salt combination includes polyquaternary ammonium salt-7, polyquaternary ammonium salt-10, and polyquaternary ammonium salt-11.

[0012] By adopting the above technical solution, plant extracts, peptides, sugar isomers, and polyquaternium salts, as active substances, are easily deactivated, which is not conducive to storage after procurement on the industrial production line. By adding them in combination with other substances, the deactivation of active substances is reduced, ensuring that the composition / shampoo product itself can fully exert its effect.

[0013] Optional components may include the following parts by weight: 1 part of selenium disulfide; Water / Butylene glycol / Sophora angustifolia root extract / Angelica polymorpha sinensis root extract / Biota orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone 0.8-1.2 parts; Glycerin / Water / Myristoyl Pentapeptide-4 / Acetyl Tetapeptide-3 / Hexapeptide-3 / Palmitoyl Tripeptide-1 0.8-1.2 parts; Carbohydrate isomers / water / citric acid / sodium citrate 0.4-0.6 parts; 1 part water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol; Polyquaternium-10 0.1 parts; Polyquaternium-11 / water / 1,2-hexanediol 0.05 parts.

[0014] Optionally, the composition further includes 0.6 parts of a liquid crystal suspension assembly comprising ethylene glycol distearate, ethylene glycol stearate, and cocoamide MEA.

[0015] By employing the above technical solution: ethylene glycol distearate (EGDS) dissolves in a surfactant system at high temperature, crystallizes during cooling to form flat, plate-like crystals, producing a pearlescent luster; cocoamide MEA is embedded between the EGDS crystal layers, enhancing the structural strength of the liquid crystal network. This layered liquid crystal network forms a three-dimensional framework structure, physically encapsulating and stably suspending selenium disulfide particles, preventing sedimentation and stratification.

[0016] Secondly, this application provides a cosmetic product, which adopts the following technical solution: A cosmetic product comprising the aforementioned mild anti-dandruff composition of selenium disulfide, and cosmetic excipients.

[0017] Optionally, the cosmetic excipients may include one or more of surfactants, humectants, thickeners, pH adjusters, chelating agents, preservatives, fragrances, anti-dandruff agents, and water.

[0018] Optionally, the cosmetic excipients include sodium C14-16 olefin sulfonate / water, lauryl betaine / water / sodium chloride, water / acrylate copolymer, glycerin, water / sodium methyl cocoyl taurate / p-hydroxyacetophenone / ethylhexylglycerin, fragrance, 1,2-hexanediol, p-hydroxyacetophenone, Argania spicosa kernel oil, guar gum hydroxypropyltrimethylammonium chloride / water, piroctone ketone ethanolamine salt, cocamidomethyl MEA / glycerin, citric acid, disodium EDTA, and water.

[0019] By adopting the above technical solution: the above cosmetic excipients are all commonly used raw materials in the cosmetic field. Among them, Argan kernel oil is rich in tocopherol (a vitamin E derivative), providing antioxidant effects in the oil phase, and synergistically delaying the oxidative discoloration of selenium disulfide with p-hydroxyacetophenone; piroctone ethanolamine salt, as an auxiliary anti-dandruff agent, complements the anti-dandruff effect of selenium disulfide; sodium methyl cocoyl taurate is an amino acid-type surfactant with good mildness, further reducing the irritation of the system. After the above excipients are compounded with the mild anti-dandruff composition of selenium disulfide, as verified by Examples 1-3, a uniform orange-yellow liquid with a pH value of 4.5-7.0 can be obtained, which meets the characteristic fragrance and has excellent overall performance.

[0020] Thirdly, this application provides a method for preparing a cosmetic product, employing the following technical solution: A method for preparing a cosmetic product includes the following steps: Preparation of phases S1, A, C, and D: Weigh water (30.77% of the total shampoo volume) and add it to the mixing bowl. Turn on the stirring and set the stirring speed to 25-30 rpm. Add guar gum hydroxypropyltrimethylammonium chloride / water and polyquaternium salt-10, and mix. Then add 1,2-hexanediol, p-hydroxyacetophenone, cocamide MEA, disodium EDTA, and ethylene glycol distearate / ethylene glycol stearate. Heat to 85-90℃ and stir until dissolved. Keep warm for 10-15 minutes to obtain phase A for later use. Mix water and water / acrylate copolymer, which together account for 10% of the total shampoo volume, to obtain phase C for later use; Glycerol and selenium disulfide were mixed to obtain phase D for later use; S2. Cool phase A to 60-65℃, add sodium C14-16 olefin sulfonate / water, lauryl betaine / water / sodium chloride, water / sodium methyl cocoyl taurate / p-hydroxyacetophenone / ethylhexylglycerin, water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol, piroctone ketone ethanolamine salt, cocamidomethyl MEA / glycerin, polyquaternium-11 / water / 1,2-hexanediol, stir at 25-30 rpm until dissolved, keep warm for 10-15 minutes, and continue cooling; S3. Continue to cool the system to 50-55℃, add the premixed C phase, stir at 25-30 rpm until dissolved, keep warm for 10-15 minutes, and continue to cool. S4. Cool the system to 45-50℃, grind the premixed D phase three times and add it to the main pot. Then add water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone, glycerin / water / myristoyl pentapeptide-4 / acetyl tetrapeptide-3 / hexapeptide-3 / palmitoyl tripeptide-1, fragrance, sugar isomers / water / citric acid / sodium citrate, Argan kernel oil, citric acid. Stir at 15-20 rpm, keep warm for 10-15 minutes, and continue to cool. S5. Cool down to below 45℃, take samples for testing, and the pH range is 4.5-7.0.

[0021] By adopting the above technical solutions: (1) the liquid crystal suspension combination is dissolved at a high temperature of 85-90℃ and then slowly cooled to form a stable layered liquid crystal network, thereby realizing the self-suspension of selenium disulfide; (2) selenium disulfide is added at a low temperature of 40-45℃ to avoid high temperature accelerating the oxidation and discoloration of selenium disulfide, thus ensuring the stability of the product appearance; (3) heat-sensitive active ingredients such as plant extract combination, polypeptide combination, and sugar isomer combination are added at a low temperature below 40℃ to fully protect their biological activity and ensure the effective formation of flavonoid-polypeptide complex; (4) the stepwise cooling process allows each component to be added under the optimal temperature conditions, which not only ensures the full dissolution and dispersion of each functional component, but also avoids the damage of heat-sensitive components to high temperature, thus ensuring the efficacy stability of the product.

[0022] In summary, this application has the following beneficial effects: 1. This application utilizes flavonoids and polyphenols abundant in Sophora flavescens root extract, Angelica sinensis root extract, and Platycladus orientalis leaf extract to form a flavonoid-peptide complex with polypeptides. At the same time, the synergistic effect of saccharide isomers and polyquaternium salts creates a rejection of excessive selenium disulfide deposition. Thus, this complex has a stronger affinity for the scalp surface than free selenium disulfide, and can preferentially adsorb to the stratum corneum of the scalp, forming a competitive binding barrier between selenium disulfide and the scalp, thereby reducing irritation. 2. In this application, a layered liquid crystal network formed by ethylene glycol distearate and cocoamide MEA is used to achieve the self-suspension stability of selenium disulfide, which shows no sedimentation after 30 days of standing. 3. The method of this application, through a step-by-step temperature control process, adds the heat-sensitive active ingredients at temperatures below 50°C, ensuring the efficacy stability of the product. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of Embodiment 1 of this application. Detailed Implementation

[0024] The present application will be further described in detail below with reference to the embodiments. The manufacturer's model or formula of each raw material is as follows, and the components are sourced from commercially available products unless otherwise specified below: C14-16 olefin sulfonate sodium / water, Hunan Lichen Aowei Industrial Co., Ltd., RSAW AOS35 / ZA; Lauryl betaine / water / sodium chloride, Migen Corporation, MITAINE L; Water / acrylate copolymer, Lubrizol Advanced Materials, Carbopol® Aqua SF-1; Glycerin, Wilmar Oils & Fats Technology Co., Ltd. Water / Sodium Methyl Cocoyl Taurate / p-Hydroxyacetophenone / Ethylhexylglycerin, Zhangjiagang Grete Chemical Co., Ltd., GREMOL CMT-30C; Fragrance & Flavor (Shanghai) Co., Ltd., RH017265; 1,2-Hexanediol, OSAKA ORGANIC CHEMICAL INDUSTRY LTD., 1,2-Hexanediol (KMO-6); p-Hydroxyacetophenone, Symrise Fragrance & Flavor (Nantong) Co., Ltd., SYMSAVE H; Cocamide MEA, BASF (China) Co., Ltd., COMPERLAN® 100 C; Argania spicosa kernel oil, DSM Nutrition Products Ltd., argan oil; Guar Gum Hydroxypropyltrimethylammonium Chloride / Water, Solvay Investment Ltd., JAGUAR C 14 S; Piroctone ethanolamine salt, Yantai Dongfang Chemical Co., Ltd., octopirox; Cocamide methyl MEA / glycerol, Shanghai Kao Chemical Co., Ltd., AMINON C-11S; Citric acid, Huaifang Yingxuan Industrial Co., Ltd., anhydrous citric acid; Ethylene glycol distearate / ethylene glycol stearate contains 90% ethylene glycol distearate and 10% ethylene glycol stearate. Selenium disulfide, Zhejiang Saikai Pharmaceutical Technology Co., Ltd. The mixture comprises water, butylene glycol, sophora flavescens root extract, angelica sinensis root extract, arborvitae leaf extract, 1,2-hexanediol, and p-hydroxyacetophenone, wherein the ingredients are 80% water, 12% butylene glycol, 4.4% sophora flavescens root extract, 1.8% angelica sinensis root extract, 1% arborvitae leaf extract, 0.4% 1,2-hexanediol, and 0.4% p-hydroxyacetophenone, obtained by conventional blending. Glycerol / water / myristoyl pentapeptide-4 / acetyl tetrapeptide-3 / hexapeptide-3 / palmitoyl tripeptide-1, wherein the components are 70% glycerol, 29.9% water, 0.043% myristoyl pentapeptide-4, 0.021% acetyl tetrapeptide-3, 0.021% hexapeptide-3, and 0.015% palmitoyl tripeptide-1, obtained by conventional blending; A mixture of water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol, comprising 59.45% water, 40% polyquaternium-7, 0.05% ethylhexylglycerin, and 0.5% phenoxyethanol, obtained by conventional blending; A mixture of carbohydrate isomers / water / citric acid / sodium citrate, comprising 61.5% carbohydrate isomers, 37.5% water, 0.5% citric acid, and 0.5% sodium citrate, obtained by conventional blending; Polyquaternium-10, Dow Chemical (Shanghai) Co., Ltd., Polymer JR 400; Polyquaternium-11 / water / 1,2-hexanediol, wherein the polyquaternium-11 contains 20%, water 77%, and 1,2-hexanediol 3%, is obtained by conventional blending.

[0025] Preparation Examples 1-3, Comparative Preparation Examples 1-6

[0026] A mild anti-dandruff composition of selenium disulfide, the components and their corresponding weights are shown in Table 1, and is obtained by conventional blending of the components.

[0027] Table 1. Components and their weights (g) in Preparation Examples 1-3 and Comparative Preparation Examples 1-6

[0028] Comparative preparation example 7

[0029] A mild anti-dandruff composition of selenium disulfide, which differs from Preparation Example 2 in that selenium disulfide particles coated with an equal amount of chitosan quaternary ammonium salt are used instead of selenium disulfide, sugar isomer / water / citric acid / sodium citrate.

[0030] Comparative Preparation Example 8

[0031] A mild anti-dandruff composition of selenium disulfide, differing from Preparation Example 2 in that a mixture of equal amounts of bisabolol, ceramide, and panthenol in a weight ratio of 0.35:0.08:0.3 is used instead of water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone.

[0032] Irritation test of the composition

[0033] Take the compositions of Preparation Examples 1-3 and Comparative Preparation Examples 1-6, add water to make up to 100g, and use it as a sample. Take 0.2mL of the sample and test it according to the "Chicken Embryo Allantoic Membrane Vascular Test" in the "Cosmetic Safety Technical Specification". The judgment criteria are: IS<1 is non-irritating, 1≤IS<5 is mild irritation, 5≤IS<10 is moderate irritation, and IS≥10 is strong irritation.

[0034] Test results

[0035] Table 2 Performance Test Results

[0036] Referring to Table 2, the compositions of Preparation Examples 1-3 have relatively low irritation. This is because the "flavonoid / polyphenol-peptide complex" has a stronger affinity for the scalp surface compared to "free selenium disulfide". It can preferentially adsorb onto the stratum corneum of the scalp and form a competitive binding barrier between selenium disulfide and the scalp, thereby reducing the direct contact of selenium disulfide on the scalp and significantly reducing irritation.

[0037] In contrast, Preparation Example 1, which did not contain the combination of water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone, and Preparation Example 2, which did not contain the combination of glycerol / water / myristoyl pentapeptide-4 / acetyl tetrapeptide-3 / hexapeptide-3 / palmitoyl tripeptide-1, respectively, lacked one of the flavonoids / polyphenols or polypeptides, and thus exhibited significantly enhanced irritation compared to Preparation Examples 1-3.

[0038] In contrast, in Preparation Example 8, bisabolol, ceramide, panthenol, and other post-exposure repair substances were used instead of water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone. The irritation was still relatively high, indicating that "post-exposure repair" can only alleviate the irritation that has already occurred and cannot prevent it from the source.

[0039] Examples 1-3 A cosmetic product, specifically an anti-dandruff shampoo, includes cosmetic excipients and a mild anti-dandruff composition of selenium disulfide, wherein the mild anti-dandruff composition of selenium disulfide comprises selenium disulfide, water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone, glycerin / water / myristoyl pentapeptide-4 / acetyl tetrapeptide-3 / hexapeptide-3 / palmitoyl tripeptide-1, water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol, saccharide isomer / water / citric acid / sodium citrate, polyquaternium-10, polyquaternium-11 / water / 1,2-hexanediol.

[0040] The components of the dandruff remover and their corresponding weights are shown in Table 3, and were prepared by the following steps: Preparation of phases S1, A, C, and D: Weigh out 30.77% of the total shampoo volume of deionized water and add it to the main pot. Turn on the stirrer at 30 rpm. Add guar gum hydroxypropyltrimethylammonium chloride / water and polyquaternium salt-10, and stir until well mixed. Then add 1,2-hexanediol, p-hydroxyacetophenone, cocamide MEA, disodium EDTA, and ethylene glycol distearate / ethylene glycol stearate. Heat to 90°C and stir until completely dissolved. Keep warm for 15 minutes to obtain phase A for later use. Weigh out 10% of the total shampoo volume of deionized water and water / acrylate copolymer, mix them in a conventional manner to obtain phase C for later use; mix glycerin and selenium disulfide in a conventional manner to obtain phase D for later use. S2. Cool phase A to 65°C, add sodium C14-16 olefin sulfonate / water, lauryl betaine / water / sodium chloride, water / sodium methyl cocoyl taurate / p-hydroxyacetophenone / ethylhexylglycerin, water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol, piroctone ketone ethanolamine salt, cocamidomethyl MEA / glycerin, polyquaternium-11 / water / 1,2-hexanediol, stir at 30 rpm until completely dissolved, keep warm for 15 minutes, and continue cooling; S3. Continue cooling the system to 55°C, add the premixed C phase, stir at 30 rpm until completely dissolved, keep warm for 15 minutes, and continue cooling. S4. Cool the system to 50℃, grind the premixed D phase three times with a grinder and add it to the main pot. Then add water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone, glycerol / water / myristoyl pentapeptide-4 / acetyl tetrapeptide-3 / hexapeptide-3 / palmitoyl tripeptide-1, fragrance, sugar isomers / water / citric acid / sodium citrate, Argan kernel oil, citric acid. Stir at 20 rpm and keep warm for 15 minutes. Then continue to cool. S5. Cool down to 45℃, take a sample for testing. The pH range is 6.1, the appearance is orange-yellow liquid, and it meets the characteristic aroma. After passing the test, the material is discharged. It should be noted that the preparation process conditions in the shampoo of this application can be selected within a certain range, depending on the amount of raw materials used, production line requirements, etc. Specific selections are as follows. These selections do not significantly affect the performance of the product itself. This embodiment only describes one of these selections, but it does not affect the application of other selections in other embodiments of this application. Specific selections are as follows: In S1, water is added to the main pot, and the stirring speed is 25-30 rpm. After adding ethylene glycol distearate / ethylene glycol stearate / polyquaternium-11, the temperature rises to 85-90℃, and the holding time is 10-15 minutes. In S2, phase A is cooled to 60-65℃, and after adding polyquaternium-11 / water / 1,2-hexanediol, the stirring speed is 25-30 rpm, and the holding time is 10-15 minutes. In S3, the system temperature drops to 50-55℃, and after adding phase C, the stirring speed is 25-30 rpm, and the holding time is 10-15 minutes. In S4, the system temperature is 45-50℃, and after adding Argan kernel oil and citric acid, the stirring speed is 15-20 rpm, and the holding time is 10-15 minutes. In S5, the pH range is 4.5-7.0.

[0041] Table 2. Components and their weights (g) in Examples 1-3

[0042] Comparative Examples 1-6

[0043] A cosmetic product, specifically an anti-dandruff shampoo, includes cosmetic excipients and a mild anti-dandruff composition of selenium disulfide. The difference from Example 2 is that the amounts of each component in the mild anti-dandruff composition of selenium disulfide are different, as detailed in Table 3.

[0044] Table 3. Components and their weights (g) in Comparative Examples 1-6

[0045] Comparative Example 7

[0046] A cosmetic product, specifically an anti-dandruff shampoo, differs from Example 2 in that it uses selenium disulfide particles coated with an equal amount of chitosan quaternary ammonium salt instead of selenium disulfide, sugar isomers / water / citric acid / sodium citrate.

[0047] Comparative Example 8

[0048] A cosmetic product, specifically an anti-dandruff shampoo, differs from Example 2 in that it uses an equal amount of bisabolol, ceramide, and panthenol in a weight ratio of 0.35:0.08:0.3 instead of water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone.

[0049] Performance testing

[0050] The shampoos prepared in the examples and comparative examples were subjected to the following performance tests, and the test results are recorded in Table 4.

[0051] Detection methods

[0052] 1. Selenium disulfide residue detection in hair strands: Take a 5g standard hair strand, rub it with 5g of shampoo for 2 minutes, rinse with water for 1 minute, and repeat once. After the hair strand is dried, the selenium content of the hair strand is determined by microwave digestion-inductively coupled plasma optical emission spectrometry (ICP-OES), and expressed as selenium residue (μg / g hair strand). The lower the selenium residue, the better the anti-deposition effect.

[0053] 2. Suspension stability test: Place the shampoo sample in a 50mL stoppered graduated cylinder and let it stand at room temperature for 30 days, observing the stratification. Record the height of the sedimentation layer (mm) and calculate the sedimentation rate (height of sedimentation layer / total height × 100%). A sedimentation rate <5% is acceptable, and a sedimentation rate ≥5% is unacceptable.

[0054] 3. Dandruff Removal Efficacy Test: Recruit 30 volunteers with dandruff problems to use the shampoo 3 times a week for 4 consecutive weeks. Use an ASI scalp analyzer to measure the percentage of dandruff area and calculate the dandruff removal rate as (1 - dandruff area after use / dandruff area before use) × 100%.

[0055] Test results

[0056] Table 4 Performance Test Results

[0057] Referring to Table 4, the shampoos in Examples 1-3 of this application exhibit low hair residue, low sedimentation rate, and high dandruff removal rate, meeting optimal usage requirements. The reason for this is that a composition stabilizing selenium disulfide is added to the shampoo. During the shampooing process, the composition utilizes sugar isomers and polyquaternary ammonium salts to reduce excessive selenium disulfide deposition, thus lowering selenium residue while ensuring excellent dandruff removal.

[0058] In contrast, the combination of water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol in Comparative Example 3 and the combination of sugar isomers / water / citric acid / sodium citrate in Comparative Example 4 showed significantly higher levels of selenium residue.

[0059] The difference between Comparative Example 7 and Example 2 is that selenium disulfide particles coated with an equal amount of chitosan quaternary ammonium salt were used instead of selenium disulfide, sugar isomers / water / citric acid / sodium citrate. The test results showed that the selenium residue in the hair increased and the dandruff removal rate decreased to 88.2%, indicating that the method of directly coating selenium disulfide could not achieve the technical effect of this application.

[0060] The difference between Comparative Example 8 and Example 2 is that a mixture of equal amounts of bisabolol, ceramide, and panthenol in a weight ratio of 0.35:0.08:0.3 was used instead of water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone. Testing showed that the dandruff-removing effect remained good, but the selenium residue in the hair was high, failing to prevent irritation from the source.

[0061] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A mild anti-dandruff composition of selenium disulfide, characterized in that, It includes the following components: Selenium disulfide, Plant extract combination polypeptide combination, Assemblance of carbohydrate isomers Polyquaternium salt combinations; The combination of plant extracts includes: Sophora flavescens root extract, Angelica sinensis root extract, and Platycladus orientalis leaf extract.

2. The mild anti-dandruff composition of selenium disulfide according to claim 1, characterized in that: The polypeptide combination includes myristoyl pentapeptide-4, acetyl tetrapeptide-3, hexapeptide-3, and palmitoyl tripeptide-1.

3. The mild anti-dandruff composition of selenium disulfide according to any one of claims 1-2, characterized in that: The plant extract combination is a mixture of water, butylene glycol, Sophora flavescens root extract, Angelica sinensis root extract, Platycladus orientalis leaf extract, 1,2-hexanediol and p-hydroxyacetophenone. The polypeptide combination is a mixture of glycerol, water, myristoyl pentapeptide-4, acetyl tetrapeptide-3, hexapeptide-3 and palmitoyl tripeptide-1; The carbohydrate isomer combination is a mixture of carbohydrate isomers, water, citric acid, and sodium citrate; The polyquaternium salt combination includes polyquaternium salt-7, polyquaternium salt-10, and polyquaternium salt-11.

4. The mild anti-dandruff composition of selenium disulfide according to claim 3, characterized in that: The components include the following parts by weight: 1 part of selenium disulfide; Water / Butylene glycol / Sophora angustifolia root extract / Angelica polymorpha sinensis root extract / Biota orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone 0.8-1.2 parts; Glycerin / Water / Myristoyl Pentapeptide-4 / Acetyl Tetapeptide-3 / Hexapeptide-3 / Palmitoyl Tripeptide-1 0.8-1.2 parts; Carbohydrate isomers / water / citric acid / sodium citrate 0.4-0.6 parts; 1 part water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol; Polyquaternium-10 0.1 parts; Polyquaternium-11 / water / 1,2-hexanediol 0.05 parts.

5. The mild anti-dandruff composition of selenium disulfide according to claim 1, characterized in that: The composition further includes 0.6 parts of a liquid crystal suspension assembly, which comprises ethylene glycol distearate, ethylene glycol stearate, and cocoamide MEA.

6. A cosmetic product comprising a mild anti-dandruff composition of selenium disulfide as described in any one of claims 1-5, and cosmetic excipients.

7. The cosmetic product according to claim 6, characterized in that: The cosmetic excipients include one or more of the following: surfactants, moisturizers, thickeners, pH adjusters, chelating agents, preservatives, fragrances, anti-dandruff agents, and water.

8. The cosmetic product according to claim 7, characterized in that: The cosmetic excipients include sodium C14-16 olefin sulfonate / water, lauryl betaine / water / sodium chloride, water / acrylate copolymer, glycerin, water / sodium methyl cocoyl taurate / p-hydroxyacetophenone / ethylhexylglycerin, fragrance, 1,2-hexanediol, p-hydroxyacetophenone, Argania spp. kernel oil, guar gum hydroxypropyltrimethylammonium chloride / water, piroctone ketone ethanolamine salt, cocamidomethyl MEA / glycerin, citric acid, disodium EDTA, and water.

9. A method for preparing the cosmetic according to claim 8, characterized in that: Includes the following steps: Preparation of phases S1, A, C, and D: Weigh water (30.77% of the total shampoo volume) and add it to the mixing bowl. Turn on the stirring and set the stirring speed to 25-30 rpm. Add guar gum hydroxypropyltrimethylammonium chloride / water and polyquaternium salt-10, and mix. Then add 1,2-hexanediol, p-hydroxyacetophenone, cocamide MEA, disodium EDTA, and ethylene glycol distearate / ethylene glycol stearate. Heat to 85-90℃ and stir until dissolved. Keep warm for 10-15 minutes to obtain phase A for later use. Mix water and water / acrylate copolymer, which together account for 10% of the total shampoo volume, to obtain phase C for later use; Glycerol and selenium disulfide were mixed to obtain phase D for later use; S2. Cool phase A to 60-65℃, add sodium C14-16 olefin sulfonate / water, lauryl betaine / water / sodium chloride, water / sodium methyl cocoyl taurate / p-hydroxyacetophenone / ethylhexylglycerin, water / polyquaternium-7 / ethylhexylglycerin / phenoxyethanol, piroctone ketone ethanolamine salt, cocamidomethyl MEA / glycerin, polyquaternium-11 / water / 1,2-hexanediol, stir at 25-30 rpm until dissolved, keep warm for 10-15 minutes, and continue cooling; S3. Continue to cool the system to 50-55℃, add the premixed C phase, stir at 25-30 rpm until dissolved, keep warm for 10-15 minutes, and continue to cool. S4. Cool the system to 45-50℃, grind the premixed D phase three times and add it to the main pot. Then add water / butanediol / Sophora flavescens root extract / Angelica sinensis root extract / Platycladus orientalis leaf extract / 1,2-hexanediol / p-hydroxyacetophenone, glycerin / water / myristoyl pentapeptide-4 / acetyl tetrapeptide-3 / hexapeptide-3 / palmitoyl tripeptide-1, fragrance, sugar isomers / water / citric acid / sodium citrate, Argan kernel oil, citric acid. Stir at 15-20 rpm, keep warm for 10-15 minutes, and continue to cool. S5. Cool down to below 45℃, take samples for testing, and the pH range is 4.5-7.0.

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