A cream dispersion containing realgar and a preparation method thereof
Patent Information
- Application Number
- CN202611086786.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-07-21
- Publication Date
- 2026-08-21
AI Technical Summary
[0003]然而，雄黄在临床应用中存在显著问题：雄黄难溶于水，生物利用度极低
本发明将纳米雄黄以固体分散体形式均匀分散于水包油型乳膏基质中，解决了雄黄在外用制剂中分散不均匀、易沉降团聚的问题。
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Figure CN122604825A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of pharmaceutical preparation technology, specifically relating to a cream dispersion containing realgar and its preparation method. Background Technology
[0002] Realgar is a traditional mineral medicine, its main component being arsenic disulfide (As2S2), which has the effects of detoxification, insecticidal properties, drying dampness and dispelling wind, and resolving phlegm and eliminating stagnation. Recent studies have shown that realgar has demonstrated good efficacy in treating malignant hematological diseases such as acute promyelocytic leukemia and chronic myeloid leukemia.
[0003] However, realgar presents significant challenges in clinical applications: it is poorly soluble in water and has extremely low bioavailability. To improve the bioavailability of realgar, researchers have attempted to prepare it into nanoscale formulations. Using polymer melt co-extrusion technology, hydrophilic nano-realgar can be prepared, which rapidly disintegrates in simulated gastric acid and intestinal fluid to form a colloidal solution, increasing the bioavailability of the original realgar by more than 12 times. Furthermore, nano-realgar liposomes can be prepared using a combination of chemical precipitation and high-pressure homogenization for thin-film dispersion. The resulting liposomes have an average particle size of approximately 102.3 nm and a drug encapsulation efficiency of 82.78%, showing good inhibitory effects on HepG2 liver cancer cells in vitro.
[0004] Regarding topical formulations, studies have employed a star-point design-response surface methodology to optimize the formulation of realgar creams. These studies investigated the effects of petrolatum dosage, emulsifier dosage, HLB value, and the transdermal absorption enhancer laurocapram on the in vitro transdermal absorption of realgar. The results indicate that simply optimizing the cream matrix coordination is insufficient to fundamentally solve the transdermal penetration problem of realgar; modification of the realgar microparticles themselves is necessary. Traditionally, realgar is often used topically in powder form to treat skin diseases such as postherpetic neuralgia. However, powders present problems such as inconvenience in use, inaccurate dosage, and easy drug detachment. Furthermore, there are safety concerns regarding topical realgar, as it contains small amounts of toxic components; long-term, large-area use may increase the risk of transdermal absorption and poisoning.
[0005] Therefore, developing a topical cream formulation that is uniformly dispersed, stable, highly permeable to the skin, and has controllable safety is of great value for expanding the clinical application of realgar. Summary of the Invention
[0006] The purpose of this invention is to overcome the shortcomings of the prior art and provide a cream dispersion containing realgar and its preparation method. This invention uses a water-soluble polymer as a carrier and employs a low-temperature solvent evaporation method to prepare a nano-realgar solid dispersion, which is then uniformly dispersed in an oil-in-water cream matrix. Simultaneously, the continuous aqueous phase of the oil-in-water cream matrix rapidly dissolves the water-soluble polymer carrier, promoting the release of realgar nanoparticles. Combined with the addition of a penetration enhancer, this significantly improves the dispersion uniformity, stability, and transdermal permeability of realgar, without causing skin irritation.
[0007] The technical solution of the present invention is as follows: A cream dispersion containing realgar, the cream dispersion comprising nano-realgar, a water-soluble polymeric carrier, a cream matrix, and a penetration enhancer; wherein, The mass ratio of the water-soluble polymer carrier to nano-realgar is 2-8:1; The water-soluble polymeric carrier is selected from one or more of polyvinylpyrrolidone, polyethylene glycol, and poloxamer. The cream base is an oil-in-water type cream base.
[0008] Furthermore, the cream base is prepared by the following method: dissolving the emulsifier in the aqueous phase, heating the aqueous phase and oil phase to 75-80°C respectively, adding the oil phase to the aqueous phase, stirring and emulsifying for 15-30 minutes, and cooling to room temperature to obtain the final product. Further, by weight, the oil phase composition is: 4-8 parts petrolatum, 1-3 parts lanolin, 1-4 parts octadecyl alcohol, 1-3 parts glyceryl monostearate, and 2-5 parts liquid paraffin. The aqueous phase composition is: 60-75 parts purified water, 3-8 parts glycerol, and 2-5 parts propylene glycol. The emulsifier is: 1-3 parts poloxamer and 0.3-1.0 parts sodium dodecyl sulfate.
[0009] Further, by weight, the cream dispersion comprises: 1 part nano-realgar, 2-8 parts water-soluble polymer carrier, 0.1-2 parts penetration enhancer, and 80-120 parts cream matrix.
[0010] Furthermore, the particle size of the nano-realgar is 50-500 nm.
[0011] Furthermore, the penetration enhancer is selected from one or more of azone, propylene glycol, and menthol.
[0012] On the other hand, the present invention provides a method for preparing the above-mentioned realgar-containing cream dispersion, comprising the following steps: S1. Preparation of realgar solid dispersion: Under nitrogen protection, the water-soluble polymer carrier was dissolved in anhydrous ethanol, nano-realgar and a penetration enhancer were added, and the mixture was ultrasonically dispersed evenly. The ethanol was removed under vacuum at 40-60℃, and the mixture was ground and sieved to obtain a realgar solid dispersion. S2. Preparation of an oil-in-water cream base: Dissolve the emulsifier in the aqueous phase, heat the aqueous phase and oil phase to 75-80℃ respectively, add the oil phase to the aqueous phase, stir and emulsify for 15-30 minutes, and cool to room temperature to obtain the product; S3: Preparation of cream dispersion by mixing: The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and stirred evenly to obtain a realgar-containing cream dispersion.
[0013] Further, in step S1, the vacuum condition is -0.06 to -0.08 MPa; the method for removing ethanol is rotary evaporation.
[0014] The present invention also provides the use of the above-mentioned realgar-containing cream dispersion in the preparation of medicaments for treating skin diseases.
[0015] Furthermore, the skin diseases include psoriasis, skin tumors, chronic ulcers, and viral skin diseases. The beneficial effects of this invention are: This invention uniformly disperses nano-realgar in the form of a solid dispersion in an oil-in-water emulsion matrix, solving the problems of uneven dispersion and easy sedimentation and agglomeration of realgar in topical preparations.
[0016] This invention uses a low-temperature solvent evaporation method to prepare realgar solid dispersion, avoiding the oxidative decomposition of realgar caused by high temperature and ensuring the stability of the drug; it selects an oil-in-water emulsion matrix, which utilizes its continuous aqueous phase to rapidly dissolve water-soluble polymer carriers, promotes the release of realgar nanoparticles, and improves the transdermal permeability of realgar.
[0017] This invention incorporates a penetration enhancer into the solid dispersion, further enhancing the transdermal absorption of realgar. The cream dispersion prepared by this invention has a light texture, is easy to apply, exhibits good patient compliance, and is suitable for long-term topical treatment. Attached Figure Description
[0018] Figure 1 These are comparison images of in vitro percutaneous penetration in Examples 1 and 1-4 of the present invention. Detailed Implementation
[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.
[0020] Example 1 A cream dispersion containing realgar, wherein the mass ratio of water-soluble polymeric carrier to nano-realgar is 5:1; Its preparation method includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 5g of polyvinylpyrrolidone K30 was dissolved in 50mL of anhydrous ethanol, and 1g of realgar with a particle size of 100nm and 0.5g of azone were added. The mixture was ultrasonically dispersed for 20min. The dispersion was transferred to a rotary evaporator and the ethanol was removed by rotary evaporation at 50℃ and -0.08 MPa vacuum. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of oil-in-water cream base Oil phase: 6g petrolatum, 2g lanolin, 3g octadecanol, 2g glyceryl monostearate, 4g liquid paraffin; Aqueous phase: 65g purified water, 5g glycerin, 3g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium lauryl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0021] Example 2 A cream dispersion containing realgar, wherein the mass ratio of water-soluble polymeric carrier to nano-realgar is 2:1; Its preparation method includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 2 g of polyethylene glycol 4000 was dissolved in 40 mL of anhydrous ethanol, 1 g of realgar with a particle size of 200 nm and 0.3 g of propylene glycol were added, and the mixture was ultrasonically dispersed for 20 min. The dispersion was then transferred to a rotary evaporator and the ethanol was removed by rotary evaporation at 50 °C and -0.07 MPa vacuum. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of oil-in-water cream base Oil phase: 5g petrolatum, 2g lanolin, 3g octadecanol, 2g glyceryl monostearate, 4g liquid paraffin; Aqueous phase: 68g purified water, 5g glycerin, 3g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium dodecyl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0022] Example 3 A cream dispersion containing realgar, wherein the mass ratio of water-soluble polymeric carrier to nano-realgar is 4:1; Its preparation method includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 4 g of poloxamer 188 was dissolved in 45 mL of anhydrous ethanol, 1 g of realgar with a particle size of 150 nm and 0.4 g of azone were added, and the mixture was ultrasonically dispersed for 20 min. The dispersion was then transferred to a rotary evaporator and the ethanol was removed by rotary evaporation at 50 °C and -0.08 MPa vacuum. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of oil-in-water cream base Oil phase: 7g petrolatum, 2g lanolin, 3g octadecanol, 2g glyceryl monostearate, 4g liquid paraffin; Aqueous phase: 62g purified water, 6g glycerin, 3g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium dodecyl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0023] Example 4 A cream dispersion containing realgar, wherein the mass ratio of water-soluble polymeric carrier to nano-realgar is 8:1; Its preparation method includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 8g of polyvinylpyrrolidone K30 was dissolved in 60mL of anhydrous ethanol, and 1g of realgar (particle size 100nm), 0.3g of azone, and 0.3g of propylene glycol were added. The mixture was ultrasonically dispersed for 20min. The dispersion was then transferred to a rotary evaporator and evaporated at 50℃ and -0.08 MPa vacuum to remove the ethanol. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of oil-in-water cream base Oil phase: 6g petrolatum, 2g lanolin, 4g octadecanol, 2g glyceryl monostearate, 5g liquid paraffin; Aqueous phase: 64g purified water, 5g glycerin, 4g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium lauryl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0024] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that in Comparative Example 1, nano-realgar was directly added to the oil-in-water emulsion matrix, and no realgar solid dispersion was prepared.
[0025] A cream dispersion containing realgar, the preparation method of which includes the following steps: S1. Preparation of an oil-in-water cream base Oil phase: 6g petrolatum, 2g lanolin, 3g octadecanol, 2g glyceryl monostearate, 4g liquid paraffin; Aqueous phase: 65g purified water, 5g glycerin, 3g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium lauryl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S2. Preparation of cream dispersion by mixing Take 1g of realgar with a particle size of 100nm and 0.5g of azone, add them to the obtained oil-in-water cream matrix, and grind them 3 times in a three-roll mill to disperse the nano realgar in the cream matrix, thus obtaining a cream dispersion containing realgar.
[0026] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the mass ratio of water-soluble polymer carrier to nano-realgar in Comparative Example 2 is 1:1.
[0027] A cream dispersion containing realgar, wherein the mass ratio of water-soluble polymeric carrier to nano-realgar is 1:1; Its preparation method includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 1 g of polyvinylpyrrolidone K30 was dissolved in 20 mL of anhydrous ethanol, and 1 g of realgar with a particle size of 100 nm and 0.5 g of azone were added. The mixture was ultrasonically dispersed for 20 min. The dispersion was transferred to a rotary evaporator and the ethanol was removed by rotary evaporation at 50 °C and -0.08 MPa vacuum. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of oil-in-water cream base Oil phase: 6g petrolatum, 2g lanolin, 3g octadecanol, 2g glyceryl monostearate, 4g liquid paraffin; Aqueous phase: 65g purified water, 5g glycerin, 3g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium lauryl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0028] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that the mass ratio of water-soluble polymer carrier to nano-realgar in Comparative Example 3 is 10:1.
[0029] A cream dispersion containing realgar, wherein the mass ratio of water-soluble polymeric carrier to nano-realgar is 10:1; Its preparation method includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 10g of polyvinylpyrrolidone K30 was dissolved in 100mL of anhydrous ethanol, and 1g of realgar with a particle size of 100nm and 0.5g of azone were added. The mixture was ultrasonically dispersed for 20min. The dispersion was transferred to a rotary evaporator and the ethanol was removed by rotary evaporation at 50℃ and -0.08MPa vacuum. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of oil-in-water cream base Oil phase: 6g petrolatum, 2g lanolin, 3g octadecanol, 2g glyceryl monostearate, 4g liquid paraffin; Aqueous phase: 65g purified water, 5g glycerin, 3g propylene glycol; Emulsifier: 2g poloxamer 188, 0.5g sodium lauryl sulfate; The emulsifier was dissolved in the aqueous phase. The aqueous and oil phases were heated to 78°C respectively. The oil phase was slowly added to the aqueous phase while stirring. After the addition was complete, the speed was increased to 1200 rpm and the mixture was continuously stirred and emulsified for 20 minutes to form a uniform emulsion. The mixture was then stirred and cooled to room temperature to obtain an oil-in-water cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0030] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that Comparative Example 4 uses an oil-in-water cream base. A cream dispersion containing realgar, the preparation method of which includes the following steps: S1. Preparation of Realgar Solid Dispersion Under nitrogen protection, 5g of polyvinylpyrrolidone K30 was dissolved in 50mL of anhydrous ethanol, and 1g of realgar with a particle size of 100nm and 0.5g of azone were added. The mixture was ultrasonically dispersed for 20min. The dispersion was transferred to a rotary evaporator and the ethanol was removed by rotary evaporation at 50℃ and -0.08 MPa vacuum. The mixture was then ground and sieved to obtain a solid dispersion of realgar. S2. Preparation of water-in-oil cream base Oil phase: 8g petrolatum, 3g lanolin, 5g octadecanol, 1g glyceryl monostearate, 6g liquid paraffin; Aqueous phase: 3mL 0.5% methylcellulose solution, 1g glycerin, 1g propylene glycol; Emulsifiers: 1g Span20, 4g poloxamer F68; Span20 was dissolved in the oil phase and poloxamer F68 was dissolved in the aqueous phase. The oil and aqueous phases were heated to 75°C respectively. The aqueous phase was slowly added to the oil phase while stirring. After the addition was complete, the mixture was stirred rapidly to emulsify it. Stirring was continued and the mixture was cooled to room temperature to obtain a water-in-oil cream base. S3. Preparation of cream dispersion by mixing The obtained realgar solid dispersion was added to the obtained water-in-oil cream matrix and ground three times in a three-roll mill to uniformly disperse the solid dispersion in the cream matrix, thus obtaining a realgar-containing cream dispersion.
[0031] Effect Example The realgar-containing cream dispersions prepared in Examples 1-4 and Comparative Examples 1-4 were sealed and stored at room temperature and 40°C for 3 months, respectively. Samples were taken at 0, 1, 2 and 3 months to observe the appearance changes. The particle size distribution (D90) of the realgar particles was determined by a laser particle size analyzer, and the As2O3 content in the realgar was determined according to the pharmacopoeia method. The results are shown in Table 1.
[0032] Table 1. Particle size, As2O3 content, and stability of the cream dispersion (room temperature)
[0033] (40℃, March)
[0034] As shown in Table 1, Examples 1-4 maintained a uniform and delicate appearance under all conditions, with no layering or sedimentation, and the particle size D90 remained below 300 nm. The As2O3 content did not increase significantly, indicating that the present invention has good stability and effectively prevents the oxidation and agglomeration of realgar. In vitro percutaneous permeation experiment Skin was taken from the back of male SD rats, subcutaneous fat and tissue were removed, and the sample was fixed in a Franz diffusion cell with a receiving cell volume of 7 mL and an effective diffusion area of 1.77 cm². 0.5 g of samples prepared in Example 1 and Comparative Examples 1-4 were uniformly applied to the skin surface. Physiological saline was added to the receiving cell, and the mixture was kept at a constant temperature of 37°C with stirring. Samples were taken at 1, 2, 4, 6, 8, 12, and 24 hours, with 1 mL of sample taken each time and immediately replenished with an isothermal volume of fresh receiving solution. The arsenic content in the receiving solution was determined by atomic fluorescence spectrometry, and the cumulative permeability per unit area (Q, μg / cm²) was calculated. The results are shown in Table 2.
[0035] Table 2 Results of in vitro percutaneous permeation experiments
[0036] As shown in Table 2, the cumulative penetration amount of realgar in Examples 1-4 was relatively high, ranging from 16.2 to 18.6 μg / cm², which was significantly higher than that in the comparative examples. The results indicate that the present invention significantly improves the transdermal permeability of realgar through the synergistic effect of the solid dispersion and the oil-in-water emulsion matrix, combined with the optimized carrier ratio and the addition of the penetration enhancer.
[0037] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.
Claims
1. A cream dispersion containing realgar, characterized in that, The cream dispersion comprises nano-realgar, a water-soluble polymeric carrier, a cream matrix, and a penetration enhancer; wherein, The mass ratio of the water-soluble polymer carrier to nano-realgar is 2-8:1; The water-soluble polymeric carrier is selected from one or more of polyvinylpyrrolidone, polyethylene glycol, and poloxamer. The cream base is an oil-in-water type cream base.
2. The cream dispersion containing realgar according to claim 1, characterized in that, The cream base is prepared by the following method: dissolving the emulsifier in the aqueous phase, heating the aqueous phase and oil phase to 75-80℃ respectively, adding the oil phase to the aqueous phase, stirring and emulsifying for 15-30 minutes, and cooling to room temperature to obtain the cream base.
3. The cream dispersion containing realgar according to claim 2, characterized in that, The oil phase composition, by weight, is: 4-8 parts petrolatum, 1-3 parts lanolin, 1-4 parts octadecanol, 1-3 parts glyceryl monostearate, and 2-5 parts liquid paraffin. The aqueous phase composition is: 60-75 parts purified water, 3-8 parts glycerol, and 2-5 parts propylene glycol. The emulsifier is: 1-3 parts poloxamer and 0.3-1.0 parts sodium dodecyl sulfate.
4. The cream dispersion containing realgar according to claim 1, characterized in that, By weight, the cream dispersion comprises: 1 part nano-realgar, 2-8 parts water-soluble polymer carrier, 0.1-2 parts penetration enhancer, and 80-120 parts cream matrix.
5. The realgar-containing cream dispersion according to claim 1, characterized in that, The particle size of the nano-realgar is 50-500 nm.
6. The cream dispersion containing realgar according to claim 1, characterized in that, The penetration enhancer is selected from one or more of azone, propylene glycol, and menthol.
7. A method for preparing a realgar-containing cream dispersion according to any one of claims 1-6, characterized in that, Includes the following steps: S1. Preparation of realgar solid dispersion: Under nitrogen protection, a water-soluble polymer carrier was dissolved in anhydrous ethanol, nano-realgar and a penetration enhancer were added, and the mixture was ultrasonically dispersed evenly. The ethanol was removed under vacuum at 40-60℃, and the mixture was ground and sieved to obtain a realgar solid dispersion. S2. Preparation of an oil-in-water emulsion base: Dissolve the emulsifier in the aqueous phase, heat the aqueous phase and oil phase to 75-80℃ respectively, add the oil phase to the aqueous phase, stir and emulsify for 15-30 minutes, and cool to room temperature to obtain the product; S3: Preparation of cream dispersion by mixing: The obtained realgar solid dispersion was added to the obtained oil-in-water cream matrix and stirred evenly to obtain a realgar-containing cream dispersion.
8. The method for preparing a realgar-containing cream dispersion according to claim 7, characterized in that, In step S1, the vacuum condition is -0.06 to -0.08 MPa; the method for removing ethanol is rotary evaporation.
9. The use of the realgar-containing cream dispersion according to any one of claims 1-6 in the preparation of a medicament for treating skin diseases.
10. The application according to claim 9, characterized in that, The skin diseases mentioned include psoriasis, skin tumors, chronic ulcers, and viral skin diseases.