A traditional Chinese medicine composition for treating chronic hand eczema, a preparation method and application thereof

Abstract

The application provides a traditional Chinese medicine composition for treating chronic hand eczema and a preparation method and application thereof. The traditional Chinese medicine composition comprises six traditional Chinese medicines, i.e., gallnut, tribulus terrestris, cannabis sativa, bletilla striata, cnidium fruit and sophora flavescens. The traditional Chinese medicine composition is used for treating chronic hand eczema and has the effects of dispelling wind and relieving itching, promoting blood circulation and moistening dryness. The gallnut and bletilla striata have the effects of astringing and healing skin, and the tribulus terrestris has the effects of dispelling wind and relieving itching, soothing liver and moistening dryness. The cannabis sativa has the effects of promoting blood circulation and moistening dryness, and nourishing skin. The traditional Chinese medicine composition has the effects of dispelling wind and relieving itching, promoting blood circulation and moistening dryness. The traditional Chinese medicine composition has the effects of relieving itching and moistening dryness, and has the characteristics of simplicity, convenience and verification. The traditional Chinese medicine composition can be prepared into granules and the like, and is given by soaking after being dissolved, which is beneficial to the transdermal absorption of the effective components of the medicine, and is especially suitable for treating the keratosis hypertrophy type chronic hand eczema.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating chronic hand eczema and its preparation method. Background Technology

[0002] Hand eczema is a common and frequently occurring clinical condition. Recent epidemiological surveys show that the prevalence, 1-year prevalence, and lifetime prevalence of hand eczema in the general population are as high as 4.0%, 9.1%, and 14.5%, respectively (Loh EW, Contact Dermatitis, 2022). Chronic hand eczema is defined as hand eczema that occurs ≥2 times per year, or each episode lasts for more than three months. Its main clinical features include thickened skin, lichenification, and hyperkeratosis.

[0003] Currently, topical medications for treating chronic hand eczema mainly include corticosteroids, calcineurin inhibitors, and retinoids. Long-term use can easily cause adverse reactions such as skin atrophy, telangiectasia, and skin barrier damage. Traditional Chinese medicine (TCM) external washes for treating chronic hand eczema have a long history, definite clinical efficacy, few side effects, and a low recurrence rate. Chinese patent CN202410007693.0 discloses a TCM preparation for treating hand eczema, composed of eight herbs including osmanthus, dried plum, salvia miltiorrhiza, purslane, and turmeric, which improves chapped hands and moisturizes the skin. However, this TCM preparation for treating hand eczema is mainly an ointment, with limited transdermal absorption efficiency, and lacks large-scale, high-quality evidence-based medicine. Further clinical validation is needed, and its clinical efficacy remains to be evaluated. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition for treating chronic hand eczema, which has the effects of dispelling wind and relieving itching, promoting blood circulation and moisturizing dryness, as well as its preparation method and application. The traditional Chinese medicine composition of this invention is formulated into granules or other dosage forms, and administered via soaking after dissolution, which facilitates the transdermal absorption of the active ingredients, making it particularly suitable for the treatment of hyperkeratotic chronic hand eczema.

[0005] To solve the above-mentioned technical problems, the present invention provides the following technical solution: A traditional Chinese medicine composition for treating chronic hand eczema, comprising the following raw material components: Gallnut 15-45 parts by weight, Tribulus terrestris 15-45 parts by weight, Cannabis sativa seed 15-45 parts by weight, Bletilla striata 5-15 parts by weight, Cnidium monnieri 5-15 parts by weight, Sophora flavescens 5-15 parts by weight.

[0006] The raw material components of the traditional Chinese medicine composition for treating chronic hand eczema are further preferably: 20 parts by weight of Gallnut, 20 parts by weight of Tribulus terrestris, 20 parts by weight of Cannabis sativa seed, 10 parts by weight of Bletilla striata, 10 parts by weight of Cnidium monnieri, and 10 parts by weight of Sophora flavescens.

[0007] The preparation method of the traditional Chinese medicine composition for treating chronic hand eczema includes the following steps: (1) Take each Chinese herb according to the above weight proportions, wash them, and set aside; (2) Add water to each of the Chinese herbs obtained in step (1), and decoct, filter and concentrate them in sequence to obtain the clear extract of each Chinese herb; (3) The Chinese herbal extracts obtained in step (2) are spray-dried and sieved to obtain Chinese herbal powders; (4) The powders of each Chinese medicine are thoroughly mixed and granulated to obtain the Chinese medicine composition.

[0008] In step (2), the gallnut extract is prepared by the following method: take gallnut, add water and decoct twice, each time adding water in amounts 5-9 times the weight of the medicinal material, decoct for 0.5-2 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.03-1.07 (40℃).

[0009] In step (2), the Tribulus terrestris extract is prepared by the following method: take Tribulus terrestris, add water and decoct twice, each time adding water at a rate of 7-11 times the weight of the medicinal material, decoct for 0.5-2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.07-1.11 (40℃).

[0010] In step (2), the hemp seed extract is prepared by the following method: take hemp seeds, add water and decoct twice, each time adding water at a rate of 7-13 times the weight of the medicinal material, decoct for 1-2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.05-1.09 (40℃).

[0011] In step (2), the Bletilla striata extract is prepared by the following method: take Bletilla striata, add water and decoct once, the amount of water is 10-16 times the weight of the medicinal material, decoct for 0.5-3 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.00-1.04 (40℃).

[0012] In step (2), the Cnidium monnieri extract is prepared by the following method: take Cnidium monnieri, add water and decoct once, the amount of water is 10-16 times the weight of the medicinal material, decoct for 0.5-2.5 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.10-1.14 (40℃); The Sophora flavescens extract is prepared by the following method: Sophora flavescens is taken, and water is added and decocted once. The amount of water added is 12-18 times the weight of the medicinal material. The decoction is decocted for 1-2.5 hours, the decoction is filtered, and the filtrate is concentrated to a clear extract with a relative density of 1.08-1.12 (40℃).

[0013] In step (3), the spray drying temperature is 70-120℃, and the particle size of the Chinese herbal powder obtained after sieving is 80-120 mesh; In step (4), the particle size of the particles obtained after dry granulation is 12-30 mesh.

[0014] The application of the traditional Chinese medicine composition in the preparation of a medicine for treating chronic hand eczema.

[0015] The traditional Chinese medicine composition described in this invention can be manufactured into various pharmaceutically acceptable dosage forms, including granules, lotions, and ointments, using conventional pharmaceutical processes. The production process is simple, product quality is stable and controllable, and the risk of contamination is low. Granules, in particular, have advantages such as long shelf life, ease of transportation and carrying, and convenient clinical use, which helps improve patient medication adherence.

[0016] Gallnut, with a sour and astringent taste and cold nature, has the effects of astringing the lungs and reducing heat, stopping cough and sweating, astringing the intestines and stopping diarrhea, consolidating essence and stopping seminal emission, astringing and stopping bleeding, and astringing dampness and healing sores. It is mainly used to treat cough, hemoptysis, spontaneous sweating, night sweats, chronic diarrhea, chronic dysentery, seminal emission, spermatorrhea, metrorrhagia, hematochezia, hemorrhoidal bleeding, damp sores, and carbuncles.

[0017] Tribulus terrestris, bitter and pungent in taste, slightly warm in nature. It soothes the liver and relieves depression, invigorates blood and dispels wind, improves eyesight, and relieves itching. It is mainly used to treat headaches and dizziness, chest and rib pain, mastitis, red and pterygium, and itchy rashes.

[0018] Hemp seeds are sweet in taste and neutral in nature. They moisten the intestines and relieve constipation. They are mainly used for blood deficiency and fluid depletion, and constipation due to intestinal dryness.

[0019] Bletilla striata has a bitter, sweet, and astringent taste, and is slightly cold in nature. It has astringent and hemostatic properties, reduces swelling, and promotes tissue regeneration. It is mainly used to treat hemoptysis, hematemesis, traumatic bleeding, sores and carbuncles, and chapped skin.

[0020] Cnidium monnieri has a pungent and bitter taste, and is warm in nature. It dries dampness and dispels wind, kills parasites and relieves itching, and warms the kidneys and strengthens yang. It is mainly used for vaginal itching and leukorrhea, eczema and itching, dampness-induced lower back pain, kidney deficiency and impotence, and infertility due to cold uterus.

[0021] Sophora flavescens has a bitter taste and is cold in nature. It clears heat and dries dampness, kills parasites, and promotes urination. It is used for dysentery, hematochezia, jaundice and urinary retention, leukorrhea, vulvar swelling and itching, eczema, damp sores, pruritus, scabies, and leprosy; externally, it is used to treat trichomonal vaginitis.

[0022] Compared with the prior art, the present invention has the following beneficial effects: This invention provides a traditional Chinese medicine composition for treating chronic hand eczema. The raw materials include six herbs: Gallnut, Tribulus terrestris, Cannabis sativa seed, Bletilla striata, Cnidium monnieri, and Sophora flavescens. This formula targets chronic hand eczema and has the effects of dispelling wind and relieving itching, promoting blood circulation and moisturizing dryness. Gallnut and Bletilla striata astringe and promote tissue regeneration, astringing sores and protecting the skin; Tribulus terrestris dispels wind and relieves itching, calms the liver and moisturizes dryness; Cannabis sativa seed promotes blood circulation, moisturizes dryness, and nourishes the skin. The synergistic combination of these herbs achieves the effects of relieving itching, dispelling wind, promoting blood circulation and moisturizing dryness. The traditional Chinese medicine composition of this invention is simple in composition yet possesses both moisturizing and antipruritic effects, reflecting the characteristics of a simple, convenient, and effective formula. The traditional Chinese medicine composition can be made into granules or other dosage forms, and can be administered by soaking after dissolution, which is conducive to the transdermal absorption of the active ingredients, especially suitable for the treatment of hyperkeratotic chronic hand eczema. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 The chart shows a stacked bar chart of the percentage of clinical efficacy in the experimental and control groups of patients in this invention. Figure 2 The images shown are before and after photos of three patients treated with the traditional Chinese medicine composition described in Example 1 of this invention. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of this invention, and not all of them. Based on the embodiments of this invention, all other implementation methods obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0026] In the following examples, 1 part by weight represents 1g, and the relative density of all extracts was measured at 40°C.

[0027] Example 1 This embodiment provides a traditional Chinese medicine composition for treating chronic hand eczema, the raw material components of which include: 20 parts by weight of Gallnut, 20 parts by weight of Tribulus terrestris, 20 parts by weight of Cannabis sativa seed, 10 parts by weight of Bletilla striata, 10 parts by weight of Cnidium monnieri, and 10 parts by weight of Sophora flavescens.

[0028] The preparation method of the traditional Chinese medicine composition for treating chronic hand eczema includes the following steps: (1) Take each Chinese herb according to the above weight proportions, select and remove impurities, wash and set aside; (2) The Chinese medicines obtained in step (1) are processed as follows to obtain the Chinese medicine extracts, as follows: Gallnut extract is prepared by the following method: take gallnut, add water and decoct twice, each time adding water at a rate of 7 times the weight of the medicinal material, decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.05. The Tribulus terrestris extract was prepared as follows: Tribulus terrestris was taken, and water was added and decocted twice. The amount of water added each time was 9 times the weight of the medicinal material. Each decoction was 1.5 hours. The decoctions were combined, filtered, and the filtrate was concentrated to a clear extract with a relative density of 1.09. The hemp seed extract is prepared by the following method: take hemp seeds, add water and decoct twice, each time adding water in a volume 10 times the weight of the medicinal material, decoct for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.07. The preparation of Bletilla striata extract is as follows: Take Bletilla striata, add water and decoct once. The amount of water added is 13 times the weight of the medicinal material. Decoction is carried out for 2 hours. The decoction is filtered and the filtrate is concentrated to a clear extract with a relative density of 1.02. The herb extract is prepared as follows: Take the herb Cnidium monnieri, add water and decoct once. The amount of water added is 13 times the weight of the herb. Decoction is taken for 1.5 hours. The decoction is filtered and the filtrate is concentrated to a clear extract with a relative density of 1.12. The Kushen extract is prepared by the following method: Take Kushen, add water and decoct once, the amount of water is 15 times the weight of the medicinal material, decoct for 1.5 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.10; (3) The Chinese herbal extracts obtained in step (2) are spray-dried and sieved at 85°C to obtain Chinese herbal powders with a particle size of 100 mesh. (4) The powders of each Chinese medicine are thoroughly mixed and granulated by dry method to obtain a Chinese medicine composition with a particle size of 20 mesh.

[0029] Example 2 This embodiment provides a traditional Chinese medicine composition for treating chronic hand eczema, the raw material components of which include: Gallnut 15 parts by weight, Tribulus terrestris 45 parts by weight, Cannabis sativa seed 15 parts by weight, Bletilla striata 15 parts by weight, Cnidium monnieri 5 parts by weight, Sophora flavescens 15 parts by weight.

[0030] The preparation method of the traditional Chinese medicine composition for treating chronic hand eczema includes the following steps: (1) Take each Chinese herb according to the above weight proportions, select and remove impurities, wash and set aside; (2) The Chinese medicines obtained in step (1) are processed as follows to obtain the Chinese medicine extracts, as follows: Gallnut extract is prepared by the following method: take gallnut, add water and decoct twice, each time adding water in a volume of 5 times the weight of the medicinal material, decoct for 2 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.03. The preparation of Tribulus terrestris extract is as follows: Take Tribulus terrestris, add water and decoct twice, each time adding water at a rate of 7 times the weight of the medicinal material, and decoct for 2.5 hours each time. Combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.07. The hemp seed extract is prepared by the following method: take hemp seeds, add water and decoct twice, each time adding water at a rate of 7 times the weight of the medicinal material, decoct for 2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.05. The preparation of Bletilla striata extract is as follows: take Bletilla striata, add water and decoct once, the amount of water is 10 times the weight of the medicinal material, decoct for 3 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.00. The herb extract is prepared as follows: Take the herb Cnidium monnieri, add water and decoct once. The amount of water added is 10 times the weight of the herb. Decoction is carried out for 2.5 hours. The decoction is filtered and the filtrate is concentrated to a clear extract with a relative density of 1.10. The Sophora flavescens extract is prepared by the following method: Sophora flavescens is taken, and water is added and decocted once. The amount of water added is 12 times the weight of the medicinal material. The decoction is decocted for 2.5 hours, the decoction is filtered, and the filtrate is concentrated to a clear extract with a relative density of 1.08. (3) The Chinese herbal extracts obtained in step (2) are spray-dried and sieved at 100°C to obtain Chinese herbal powders with a particle size of 120 mesh. (4) The powders of each Chinese medicine are thoroughly mixed and granulated by dry method to obtain a Chinese medicine composition with a particle size of 12 mesh.

[0031] Example 3 This embodiment provides a traditional Chinese medicine composition for treating chronic hand eczema, the raw material components of which include: Gallnut 45 parts by weight, Tribulus terrestris 15 parts by weight, Cannabis sativa seed 45 parts by weight, Bletilla striata 5 parts by weight, Cnidium monnieri 15 parts by weight, Sophora flavescens 5 parts by weight.

[0032] The preparation method of the traditional Chinese medicine composition for treating chronic hand eczema includes the following steps: (1) Take each Chinese herb according to the above weight proportions, select and remove impurities, wash and set aside; (2) The Chinese medicines obtained in step (1) are processed as follows to obtain the Chinese medicine extracts, as follows: Gallnut extract is prepared by the following method: take gallnut, add water and decoct twice, each time adding water in a volume 9 times the weight of the medicinal material, decoct for 0.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.07; The preparation of Tribulus terrestris extract is as follows: Take Tribulus terrestris, add water and decoct twice, each time adding water in an amount 11 times the weight of the medicinal material, decoct for 0.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.11. The hemp seed extract is prepared by the following method: take hemp seeds, add water and decoct twice, each time adding water in a volume 13 times the weight of the medicinal material, decoct for 1 hour each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.09. The preparation of Bletilla striata extract is as follows: Take Bletilla striata, add water and decoct once, the amount of water being 16 times the weight of the medicinal material, decoct for 0.5 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.04. The herb extract is prepared as follows: Take the herb Cnidium monnieri, add water and decoct once. The amount of water added is 16 times the weight of the herb. Decoction is taken for 0.5 hours. The decoction is filtered and the filtrate is concentrated to a clear extract with a relative density of 1.14. The Kushen extract is prepared by the following method: Take Kushen, add water and decoct once, the amount of water is 18 times the weight of the medicinal material, decoct for 1 hour, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.12. (3) The herbal extracts obtained in step (2) are spray-dried and sieved at 110°C to obtain herbal powders with a particle size of 120 mesh. (4) The powders of each Chinese medicine are thoroughly mixed and granulated by dry method to obtain a Chinese medicine composition with a particle size of 30 mesh.

[0033] Experimental Example 1 1. Case selection and grouping From March 2025 to March 2026, patients meeting the diagnostic criteria for chronic hand eczema of the blood deficiency and wind-dryness type were recruited at the dermatology outpatient clinic of a traditional Chinese medicine hospital. The main clinical manifestations were erythema, desquamation, fissures, and severe itching on the hands. Currently, 56 patients have completed the treatment course and follow-up, and were randomly divided into an experimental group and a control group, with 28 patients in each group. The experimental group was treated with the traditional Chinese medicine composition of Example 1 of this invention, while the control group was treated with mometasone furoate cream. There were no statistically significant differences between the two groups in baseline data such as gender, age, course of disease, body mass index (BMI), and lesion site. P > 0.05), which is comparable.

[0034] 2. Evaluation Indicators The primary efficacy endpoints were the Hand Eczema Severity Index (HECSI) score and the Numerical Rating Scale for Pruritus (NRS) score; secondary efficacy endpoints were the Investigator Global Assessment (IGA) score, the Dermatology Quality of Life Index (DLQI) score, the Patient Self-Assessment Scale for Eczema (POEM) score, and the area of ​​target lesions. Overall clinical efficacy was determined by the rate of decrease in the sum of the HECSI and NRS scores.

[0035] 3. Efficacy and safety results (1) Main efficacy: After 4 weeks of treatment, the HECSI score and NRS score of the experimental group were better than those of the control group. Regarding the speed of onset, at week 2 of treatment, the mean decrease in NRS score from baseline in the experimental group was significantly greater than that in the control group. P =0.010), indicating that the herbal composition of the present invention has the advantage of quickly relieving itching in the early stage.

[0036] (2) Secondary efficacy: Intragroup longitudinal comparisons showed that the target lesion area was significantly reduced from baseline at weeks 2 and 4 of treatment in the experimental group. P < 0.05); the DLQI score and POEM score, which reflect the patient's quality of life, also decreased significantly from baseline at weeks 2 and 4 of treatment. P < 0.05).

[0037] (3) Clinical efficacy rate: After 4 weeks of treatment, the total clinical efficacy rate in the experimental group was 71.4%. The clinical efficacy rate in the experimental group was 35.7%, significantly higher than that in the control group (10.7%), and the difference between the two groups was statistically significant. P < 0.05).

[0038] Specifically, see Table 1 and... Figure 1-2 As shown.

[0039] Table 1 - Clinical efficacy rates in the experimental and control groups Note: ▲ indicates P < 0.05; The Mann-Whitney U test was used, and the statistic was . Z b. The chi-square test was used, and the statistical value was χ². 2 .

[0040] (4) Safety: No serious adverse reactions were reported in either group of patients during the study period, and no significant abnormalities were found in vital signs and laboratory test indicators, indicating that the traditional Chinese medicine composition of the present invention has good safety.

[0041] The present invention discloses a traditional Chinese medicine composition for treating chronic hand eczema. The raw materials include six herbs: Gallnut, Tribulus terrestris, Cannabis sativa seed, Bletilla striata, Cnidium monnieri, and Sophora flavescens. This formula targets chronic hand eczema and has the effects of dispelling wind and relieving itching, promoting blood circulation and moisturizing dryness. Gallnut and Bletilla striata astringe and promote tissue regeneration, and heal sores and protect the skin; Tribulus terrestris dispels wind and relieves itching, calms the liver and moisturizes dryness; Cannabis sativa seed promotes blood circulation, moisturizes dryness, and nourishes the skin. The synergistic combination of these herbs achieves the effects of relieving itching, dispelling wind, promoting blood circulation and moisturizing dryness. The traditional Chinese medicine composition of the present invention is simple in composition yet possesses both moisturizing and antipruritic effects, reflecting the characteristics of a simple, convenient, and effective formula. The traditional Chinese medicine composition can be formulated into granules or other dosage forms, and can be administered by soaking after dissolution, which is conducive to the transdermal absorption of the active ingredients, especially suitable for the treatment of hyperkeratotic chronic hand eczema.

[0042] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating chronic hand eczema, characterized in that, The raw material components include: Gallnut 15-45 parts by weight, Tribulus terrestris 15-45 parts by weight, Cannabis sativa seed 15-45 parts by weight, Bletilla striata 5-15 parts by weight, Cnidium monnieri 5-15 parts by weight, Sophora flavescens 5-15 parts by weight.

2. The traditional Chinese medicine composition for treating chronic hand eczema according to claim 1, characterized in that, The raw material components include: 20 parts by weight of Gallnut, 20 parts by weight of Tribulus terrestris, 20 parts by weight of Cannabis sativa seed, 10 parts by weight of Bletilla striata, 10 parts by weight of Cnidium monnieri, and 10 parts by weight of Sophora flavescens.

3. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to any one of claims 1-2, characterized in that, Includes the following steps: (1) Take each Chinese herb according to the above weight proportions, wash them, and set aside; (2) Add water to each of the Chinese herbs obtained in step (1), and decoct, filter and concentrate them in sequence to obtain the clear extract of each Chinese herb; (3) The Chinese herbal extracts obtained in step (2) are spray-dried and sieved to obtain Chinese herbal powders; (4) The powders of each Chinese medicine are thoroughly mixed and granulated to obtain the Chinese medicine composition.

4. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to claim 3, characterized in that, In step (2), the gallnut extract is prepared by the following method: take gallnut, add water and decoct twice, each time adding water at a rate of 5-9 times the weight of the medicinal material, decoct for 0.5-2 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.03-1.

07.

5. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to claim 4, characterized in that, In step (2), the Tribulus terrestris extract is prepared by the following method: take Tribulus terrestris, add water and decoct twice, each time adding water at a rate of 7-11 times the weight of the medicinal material, decoct for 0.5-2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.07-1.

11.

6. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to claim 3, characterized in that, In step (2), the hemp seed extract is prepared by the following method: take hemp seeds, add water and decoct twice, each time adding water at a rate of 7-13 times the weight of the medicinal material, decoct for 1-2.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.05-1.

09.

7. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to claim 3, characterized in that, In step (2), the Bletilla striata extract is prepared by the following method: take Bletilla striata, add water and decoct once, the amount of water is 10-16 times the weight of the medicinal material, decoct for 0.5-3 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.00-1.

04.

8. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to claim 3, characterized in that, In step (2), the Cnidium monnieri extract is prepared by the following method: take Cnidium monnieri, add water and decoct once, the amount of water is 10-16 times the weight of the medicinal material, decoct for 0.5-2.5 hours, filter the decoction, and concentrate the filtrate to a clear extract with a relative density of 1.10-1.14; The Sophora flavescens extract is prepared by the following method: Sophora flavescens is taken, and water is added and decocted once. The amount of water added is 12-18 times the weight of the medicinal material. The decoction is decocted for 1-2.5 hours, the decoction is filtered, and the filtrate is concentrated to a clear extract with a relative density of 1.08-1.

12.

9. The method for preparing the traditional Chinese medicine composition for treating chronic hand eczema according to claim 3, characterized in that, In step (3), the spray drying temperature is 70-120℃, and the particle size of the Chinese herbal powder obtained after sieving is 80-120 mesh; In step (4), the particle size of the particles obtained after dry granulation is 12-30 mesh.

10. The use of the traditional Chinese medicine composition according to any one of claims 1-2 or the traditional Chinese medicine composition prepared by the method according to any one of claims 3-9 in the preparation of a medicament for treating chronic hand eczema.

Images