A pet oral cleaning lozenge and a preparation method thereof

Abstract

This invention discloses a pet oral cleaning lozenge and its preparation method. The pet oral cleaning lozenge of this invention is made from the following raw materials in the indicated weight percentages: 50%~65% rapid-disintegrating matrix, 1%~2% lysozyme, 3%~5% tea polyphenols, 0.5%~1% DL-panthenol, 0.5%~1% vitamin C, 1%~2% licorice extract, 2%~3% peppermint extract, 0.5%~2% honeysuckle extract, 0~1% cactus extract, 0~1% ophiopogon japonicus extract, 2.5%~4% nutrients, 5%~8% flavor modifier, and the balance being filler. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria cocos powder, with the mass ratio of kudzu root powder, yam powder, coix seed powder, and poria cocos powder being 0.3~0.5:0.2~0.3:0.1~0.3:0.1~0.2. The pet oral cleaning lozenges of the present invention can achieve rapid disintegration without the use of traditional disintegrants, and have good hardness and storage stability, as well as excellent teeth cleaning, gum protection and breath freshening effects.

Description

Technical Field

[0001] This invention relates to the field of pet oral care technology, specifically to a pet oral cleaning lozenge and its preparation method. Background Technology

[0002] With the increasing pet ownership rate, pet oral health issues are receiving more and more attention. Bad breath, plaque, tartar, and gingivitis not only affect pets' quality of life, but can also lead to periodontal disease and even affect their internal organ health in the long run. Currently, pet oral hygiene products on the market mainly include dental chews, dental toothpaste, and regular dental tablets, but they have many drawbacks: dental chews require pets to chew them, making them unsuitable for picky eaters, senior pets with loose teeth, or puppies and kittens; dental toothpaste requires brushing, which pets generally resist, making it inconvenient to use; regular dental tablets disintegrate slowly, some products are prone to absorbing moisture and disintegrating, making storage inconvenient, and their cleaning and protective effects are limited, with incomplete odor removal.

[0003] Furthermore, some dry-pressed dental chewing tablets incorporate pharmaceutical excipients such as microcrystalline cellulose, crospovidone, and low-substituted hydroxypropyl cellulose. However, crospovidone and low-substituted hydroxypropyl cellulose are highly cross-linked or insoluble polymeric disintegrants. While they can promote tablet disintegration in the moist oral environment, they themselves lack water solubility or can only swell to a limited extent. After the tablet disintegrates, these components often cannot be completely dissolved, remaining in the oral cavity as hard, undispersed microparticles or incompletely dispersed flocculent aggregates. These hard, insoluble particles resulting from incomplete disintegration significantly contribute to a gritty and rough sensation, severely affecting the smoothness of the mouthfeel and the overall user experience during dissolution, and also impacting the release of the active ingredients to some extent. Furthermore, most existing products only soothe surface discomfort of the gums and cannot simultaneously repair damaged gum barriers, failing to address the root cause of gum sensitivity and fragility. Current manufacturing processes often employ wet granulation followed by tableting, a cumbersome process with high production costs. The granulation process may also affect the activity of disintegrating and active ingredients. Additionally, existing products do not optimize disintegration rates for different tablet thicknesses, resulting in significant differences in disintegration rates for different thicknesses, making it impossible to accurately match the oral conditions and usage needs of different pets. More importantly, the existing oral disintegrating tablets have an unreasonable hardness design, lacking sufficient rigidity, making them prone to breakage during transportation and handling, affecting product appearance and effectiveness, increasing production costs and losses. Therefore, the development of a pet oral cleaning lozenge that eliminates microcrystalline cellulose, crospovidone, and low-substituted hydroxypropyl cellulose, adopts a direct compression process from traditional Chinese medicine powder, achieves precise disintegration and transport to prevent breakage through synergistic optimization of thickness and hardness, balances sealing stability and high-speed disintegration, and adds ingredients that can repair the gingival barrier, and has excellent dental care and deodorizing effects, has become an urgent need in the current pet care field. Summary of the Invention

[0004] In view of the above problems, the purpose of this invention is to provide a pet oral cleaning lozenge and its preparation method. The pet oral cleaning lozenge can achieve rapid disintegration without the use of traditional disintegrants, and has good hardness and storage stability, as well as excellent teeth cleaning, gum protection and breath freshening effects.

[0005] To achieve the above objectives, the present invention provides a pet oral cleaning lozenge, made from the following raw materials in the indicated weight percentages: 48%~55% disintegrating matrix, 1%~2% lysozyme, 3%~5% tea polyphenols, 0.5%~1% DL-panthenol, 0.5%~1% vitamin C, 1%~2% licorice extract, 2%~3% peppermint extract, 0.5%~2% honeysuckle extract, 0~1% cactus extract, 0~1% ophiopogon japonicus extract, 2.5%~4% nutrients, 5%~8% flavor modifier, and the balance being filler. The disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria cocos powder, with the mass ratio of kudzu root powder, yam powder, coix seed powder, and poria cocos powder being 0.3~0.5:0.2~0.3:0.1~0.3:0.1~0.2.

[0006] Compared with existing technologies, the pet oral cleaning lozenges of the present invention (hereinafter sometimes referred to as lozenges) can achieve rapid disintegration without the use of traditional disintegrants, and have better hardness and storage stability, as well as excellent teeth cleaning, gum protection and breath freshening effects, as detailed below: (1) In the prior art, kudzu root, yam, coix seed powder, and poria cocos powder, which are both food and medicine, are rich in starch and cellulose. They mainly play the roles of binding, filling, or their respective effects. To achieve rapid disintegration in the oral cavity, traditional chemical disintegrants such as cross-linked povidone, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose are usually required. However, through extensive formulation screening during the research and development process, the inventors discovered that by compounding kudzu root powder, yam powder, coix seed powder, and poria cocos powder in a specific ratio (0.3~0.5:0.2~0.3:0.1~0.3:0.1~0.2), rapid disintegration (disintegration time of 10s~30s) can be achieved without the use of traditional disintegrants, and the lozenges of the present invention have better hardness and storage stability. The inventors speculate that this may be because kudzu root powder and yam powder have good formability and stability, allowing for direct tableting and providing the lozenges with good hardness, thus ensuring their stability during storage and transportation. These two substances also possess a certain degree of water absorption and good flowability, laying the foundation for rapid disintegration. Poria cocos powder has a high amount of coarse fiber, resulting in good water permeability. Coix seed powder has excellent water absorption and swelling properties; when combined with Poria cocos powder, it rapidly absorbs water and swells upon contact with moisture (saliva), causing the lozenges to break down and disperse quickly. The resulting disintegration products are fine and do not contain hard, insoluble particles. Therefore, through the synergistic combination of these four substances, the stability of the lozenges during sealed storage, their direct tableting formability, and the hardness required for transportation are ensured, while also achieving rapid disintegration upon contact with moisture (saliva).

[0007] (2) The lysozyme and tea polyphenols in the lozenges of the present invention can achieve a good effect on removing dental plaque; the synergistic effect of DL-panthenol, vitamin C and licorice extract can achieve a good effect on protecting gums; peppermint extract, honeysuckle extract, cactus extract and / or ophiopogon japonicus extract can achieve a good effect on eliminating odors. Moreover, the disintegration matrix of the present invention can effectively promote the disintegration and release of the aforementioned active ingredients and increase the disintegration rate. Therefore, the oral cleaning lozenges of the present invention have excellent effects on cleaning teeth, protecting gums and freshening breath.

[0008] As a preferred technical solution, the mass ratio of kudzu root powder, yam powder, coix seed powder and poria powder in this invention is 0.4:0.25:0.2:0.15.

[0009] As a preferred technical solution, the enzyme activity of the lysozyme of the present invention is not less than 20000U / mg.

[0010] As a preferred technical solution, the purity of the tea polyphenols in this invention is not less than 98%.

[0011] As a preferred technical solution, the purity of DL-panthenol of the present invention is not less than 95%.

[0012] As a preferred technical solution, the filler of the present invention is maltodextrin.

[0013] As a preferred technical solution, the nutritional components of the present invention include at least one of trace elements and amino acids.

[0014] As a preferred technical solution, the flavor modifier of the present invention includes at least one of natural chicken extract and natural fish extract.

[0015] As a preferred technical solution, the pet oral cleaning lozenge of the present invention has a diameter of 5mm~10mm, a thickness of 3mm~5mm, a hardness of 9MPa~16MPa, and a disintegration time of 10s~30s.

[0016] Another aspect of the present invention provides a method for preparing the aforementioned pet oral cleaning lozenges, comprising the steps of: (1) The raw materials are crushed, sieved and dried to obtain raw material pretreatment material; (2) Weigh out the pre-treated raw materials according to the formula and mix them evenly to obtain the mixture; (3) Compress the mixture into tablets.

[0017] As a preferred technical solution, step (1) specifically includes crushing the raw materials in a pulverizer and passing them through a 60~120 mesh sieve, and drying them in an environment with a temperature of 20℃~25℃ and a relative humidity of ≤40% to obtain a raw material pretreatment material with a moisture content of no more than 3%.

[0018] As a preferred technical solution, in step (2), the mixing and stirring are carried out in a mixer, the mixing speed is 2000r / min~2500r / min, and the time is 10min~30min.

[0019] As a preferred technical solution, in step (3), the tableting process is carried out in a tablet press, the tableting pressure is 10MPa~16MPa, and the tableting speed is 30~50 tablets / minute. Detailed Implementation

[0020] The pet oral cleaning lozenges of the present invention can achieve rapid disintegration without the use of traditional disintegrants, and have good hardness and storage stability, as well as excellent teeth cleaning, gum protection and breath freshening effects. Specifically, the pet oral cleaning lozenges of the present invention are made from the following raw materials in the following weight percentages: 48%~55% rapid disintegrating matrix, 1%~2% lysozyme, 3%~5% tea polyphenols, 0.5%~1% DL-panthenol, 0.5%~1% vitamin C, 1%~2% licorice extract, 2%~3% peppermint extract, 0.5%~2% honeysuckle extract, 0~1% cactus extract, 0~1% ophiopogon japonicus extract, 2.5%~4% nutrients, 5%~8% flavor modifiers and the balance being fillers.

[0021] The mass percentage of the rapid-disintegrating matrix can be, but is not limited to, 48%, 49%, 50%, 51%, 52%, 53%, 54%, or 55%. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria powder. The mass ratio of kudzu root powder, yam powder, coix seed powder, and poria powder can be 0.3~0.5:0.2~0.3:0.1~0.3:0.1~0.2. Further, the preferred mass ratio is 0.4:0.25:0.2:0.15. Using kudzu root powder, yam powder, coix seed powder, and poria powder in a mass ratio of 0.4:0.25:0.2:0.15 can most effectively shorten the disintegration time, promote the disintegration and release of active ingredients, and improve the disintegration rate.

[0022] The mass percentage of lysozyme may be, but is not limited to, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0%. The mass percentage of tea polyphenols may be, but is not limited to, 3.0%, 3.2%, 3.4%, 3.5%, 3.6%, 3.8%, 4.0%, 4.2%, 4.4%, 4.5%, 4.6%, 4.8%, or 5.0%. The lysozyme must be food-grade animal-derived lysozyme with an enzyme activity of not less than 20,000 U / mg. Lysozyme can effectively disrupt the cell walls of harmful bacteria in the oral cavity, inhibit the growth of harmful bacteria, reduce plaque formation, and strengthen the surface protection of pet teeth, preventing tooth wear and cavities. The tea polyphenols are green tea extracts with a purity of not less than 98%. Tea polyphenols can penetrate deep into dental plaque, gradually dissolving plaque and tartar on the tooth surface, preventing tartar formation at its source. They also have antibacterial properties, helping to protect oral health and neutralize bad breath. Therefore, combining lysozyme and tea polyphenols can achieve excellent dental care results.

[0023] The mass percentage of Vitamin C may be, but is not limited to, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%. The mass percentage of Licorice Extract may be, but is not limited to, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0%. The mass percentage of DL-Panthenol may be, but is not limited to, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%, and the DL-Panthenol must be food-grade DL-Panthenol with a purity of not less than 95%. Licorice extract can gently soothe swollen and inflamed gums and relieve oral discomfort in pets; Vitamin C can enhance gum resistance and prevent gum bleeding; DL-panthenol can effectively repair the gum barrier, penetrate the gum surface, repair damaged gum mucosa, enhance gum barrier function, and relieve gum sensitivity and fragility. It can also work synergistically with Vitamin C and licorice extract to further enhance the gum protection effect and improve pet gum health from the root.

[0024] The mass percentage of peppermint extract may be, but is not limited to, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, or 3.0%. The mass percentage of honeysuckle extract may be, but is not limited to, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2.0%. The mass percentage of cactus extract may be, but is not limited to, 0%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%. The mass percentage of Ophiopogon japonicus extract may be, but is not limited to, 0%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%. Peppermint extract quickly neutralizes bad breath, providing a fresh taste, while honeysuckle extract has antibacterial, anti-inflammatory, and breath-freshening effects. The combination of these two ingredients effectively eliminates the root causes of bad breath (such as volatile sulfur compounds produced by the fermentation of food residue), achieving a long-lasting fresh breath effect. Further introduction of Ophiopogon japonicus extract and cactus extract further enhances the removal of volatile sulfur compounds.

[0025] The percentage of nutrients by mass may be, but is not limited to, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, or 4.0%. Nutrients include at least one of trace elements and amino acids. Trace elements (such as calcium, phosphorus, and zinc) supplement the nutrients needed for pet tooth growth and strengthen teeth; amino acids enhance the pet's immunity, achieving the dual effect of cleaning teeth and supplementing nutrition.

[0026] The flavor modifier's mass percentage may be, but is not limited to, 5.0%, 5.2%, 5.4%, 5.5%, 5.6%, 5.8%, 6.0%, 6.2%, 6.4%, 6.5%, 6.6%, 6.8%, 7.0%, 7.2%, 7.4%, 7.5%, 7.6%, 7.8%, or 8.0%. The flavor modifier includes at least one of natural chicken extract and natural fish extract. The flavor modifier can be tailored to the taste preferences of cats and dogs, increasing pet acceptance and addressing the issue of pets resisting dental cleaning products.

[0027] The filler can be maltodextrin. Maltodextrin has good formability and solubility, which can further ensure the hardness of the lozenges and the flowability of direct compression, while not affecting the disintegration rate and the release of active ingredients, and helping to improve the lozenges' resistance to breakage.

[0028] The preparation method of the pet oral cleaning lozenge of the present invention includes the following steps: (1) crushing, sieving and drying the raw materials to obtain raw material pretreatment materials; (2) weighing the formula amount of each raw material pretreatment material and mixing and stirring evenly to obtain a mixture; (3) compressing the mixture into tablets.

[0029] Step (1) specifically includes crushing the raw materials in a pulverizer and passing them through a 100-150 mesh sieve, then drying them in an environment with a temperature of 20℃-25℃ and a relative humidity of ≤40% to obtain a pre-treated raw material with a moisture content of no more than 3%. Specifically, the mesh size of the sieve can be, but is not limited to, 100 mesh, 105 mesh, 110 mesh, 115 mesh, 120 mesh, 125 mesh, 130 mesh, 135 mesh, 140 mesh, 145 mesh, or 150 mesh; the drying temperature can be, but is not limited to, 20℃, 21℃, 22℃, 23℃, 24℃, or 25℃; and the relative humidity can be, but is not limited to, 40%, 38%, 36%, 35%, 34%, 32%, 30%, or 28%.

[0030] In step (2), the mixing is carried out in a mixer at a speed of 2000 r / min to 2500 r / min for a time of 10 min to 30 min. Specifically, the mixing speed can be, but is not limited to, 2000 r / min, 2050 r / min, 2100 r / min, 21500 r / min, 2200 r / min, 2250 r / min, 2300 r / min, 2350 r / min, 2400 r / min, 2450 r / min, or 2500 r / min; and the mixing time can be, but is not limited to, 10 min, 15 min, 20 min, 25 min, or 30 min.

[0031] In step (3), the tableting process is carried out in a tablet press. The tableting pressure is 10MPa~16MPa, and the tableting speed is 30~50 tablets / minute. The tableting pressure can be, but is not limited to, 10MPa, 11MPa, 12MPa, 13MPa, 14MPa, 15MPa, or 16MPa; the tableting speed can be, but is not limited to, 30 tablets / minute, 35 tablets / minute, 40 tablets / minute, 45 tablets / minute, or 50 tablets / minute. Specifically, when compressing tablets with a diameter of 8mm~10mm and a thickness of 3mm~5mm, the relative humidity of the environment is maintained at ≤40% during the tableting process to prevent premature disintegration due to moisture absorption. Simultaneously, precise control of thickness and pressure ensures uniform hardness and avoids the risk of breakage during transportation. More specifically, when preparing pet oral cleaning lozenges with a thickness of 3mm, the compression pressure can be 10MPa~12MPa, ensuring a hardness of 9MPa~10MPa and rapid disintegration in about 15s; when preparing pet oral cleaning lozenges with a thickness of 4mm, the compression pressure can be 12MPa~14MPa, ensuring a hardness of 10MPa~12MPa and rapid disintegration in about 20s; when preparing pet oral cleaning lozenges with a thickness of 5mm, the compression pressure can be 14MPa~16MPa, ensuring a hardness of 12MPa~14MPa and rapid disintegration in about 30s. After compression, the lozenges are screened to remove damaged, unevenly sized, unqualified hardness (deviation from the preset hardness range for the corresponding thickness), or excessive thickness deviation products. Qualified lozenges are individually packaged in small aluminum foil packets, each containing a desiccant, thus obtaining the pet oral cleaning lozenges of this invention.

[0032] To better illustrate the purpose, technical solution, and beneficial effects of this invention, the invention will be further described below with reference to specific embodiments. It should be noted that the methods described below are further explanations of this invention and should not be construed as limiting it.

[0033] In the embodiments and comparative examples of this invention, kudzu root powder was purchased from Xi'an Jincuifang Plant Technology Development Co., Ltd., with a purity of over 95%; yam powder was purchased from Hebei Hongtao Bioengineering Co., Ltd., with a purity of over 95%; coix seed powder was purchased from Xi'an Jincuifang Plant Technology Development Co., Ltd., with a purity of over 95%; poria cocos powder was purchased from Hebei Hongtao Bioengineering Co., Ltd., with a purity of over 95%; lysozyme was purchased from Nanning Pangbo Bioengineering Co., Ltd., with an enzyme activity of 20000 U / mg; tea polyphenols were purchased from Jinhua Baikang Bioengineering Co., Ltd., with a purity of over 95%; DL-panthenol was purchased from Shanghai Yuanye Biotechnology Co., Ltd., with a purity of 99%; and licorice extract was purchased from Hebei Hongtao Bioengineering Co., Ltd. The following raw materials were purchased from various companies: Mint extract (pureness ≥ 95%), Honeysuckle extract (pureness ≥ 95%), Ophiopogon japonicus extract (pureness ≥ 95%), Cactus extract (pureness ≥ 95%), Trace elements (pureness ≥ 99%), Amino acids (pureness ≥ 99%), Natural chicken extract (pureness ≥ 99%), and Natural fish extract (pureness ≥ 99%). All other raw materials not specified herein are commercially available.

[0034] Example 1 This embodiment provides a pet oral cleaning lozenge made from the following raw materials in the indicated weight percentages: 50% rapid-disintegrating matrix, 1% lysozyme, 3% tea polyphenols, 0.5% DL-panthenol, 0.5% vitamin C, 1% licorice extract, 2% peppermint extract, 1% honeysuckle extract, 0.5% trace elements, 2% amino acids, 5% natural chicken extract, and 33.5% maltodextrin. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria cocos powder in a weight ratio of 0.4:0.25:0.2:0.15.

[0035] This embodiment also provides a method for preparing the pet oral cleaning lozenge, including the following steps: (1) Crush the raw materials in a pulverizer and pass them through an 80-mesh sieve. Place them in an environment with a temperature of 20℃ and a relative humidity of 35% to dry them for later use. Ensure that the moisture content of the raw materials is ≤3% and the particle size is uniform to obtain the raw material pretreatment material. (2) Weigh the pre-treated raw materials according to the formula, put them into a high-speed mixer, adjust the speed to 2000 r / min, and mix for 20 min to obtain the mixture; (3) Place the mixture in a tablet press, adjust the tableting pressure to 11MPa, the tableting speed to 30 tablets / minute, and press it into a thin sheet with a diameter of 8mm and a thickness of 3mm. The relative humidity of the tableting environment is 35%, and the thickness deviation of the tablet is controlled to be ≤±0.1mm. Qualified tablets are screened, and products with excessive thickness deviation or damage are removed. The tablets are individually packaged in aluminum foil, and a desiccant is placed inside the package to obtain pet oral cleaning tablets.

[0036] Example 2 This embodiment provides a pet oral cleaning lozenge made from the following raw materials in the indicated weight percentages: 52% rapid-disintegrating matrix, 1.5% lysozyme, 4% tea polyphenols, 1.0% DL-panthenol, 0.8% vitamin C, 1.5% licorice extract, 2.5% peppermint extract, 1.5% honeysuckle extract, 0.7% trace elements, 2.5% amino acids, 6.5% natural fish extract, and 25.5% maltodextrin. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria powder in a weight ratio of 0.4:0.25:0.2:0.15.

[0037] This embodiment also provides a method for preparing the pet oral cleaning lozenge, including the following steps: (1) The raw materials are crushed in a pulverizer and passed through a 90-mesh sieve. They are then dried in an environment with a temperature of 22°C and a relative humidity of 38% to ensure that the moisture content of the raw materials is ≤3% and the particle size is uniform to obtain the raw material pretreatment material. (2) Weigh the pre-treated raw materials according to the formula, put them into a high-speed mixer, adjust the speed to 2200 r / min, and mix for 18 min to obtain the mixture; (3) Place the mixture in a tablet press, adjust the tableting pressure to 13MPa, the tableting speed to 40 tablets / minute, and press it into a thin sheet with a diameter of 9mm and a thickness of 4mm. The relative humidity of the tableting environment is 38%, and the thickness deviation of the tablet is controlled to be ≤±0.1mm. Qualified tablets are screened, and products with excessive thickness deviation or damage are removed. The tablets are individually packaged in aluminum foil, and a desiccant is placed inside the package to obtain pet oral cleaning tablets.

[0038] Example 3 This embodiment provides a pet oral cleaning lozenge made from the following raw materials in the indicated weight percentages: 55% rapid-disintegrating matrix, 2% lysozyme, 5% tea polyphenols, 1.5% DL-panthenol, 1.0% vitamin C, 2% licorice extract, 3% peppermint extract, 2% honeysuckle extract, 1.0% trace elements, 3% amino acids, 8% natural chicken extract, and 16.5% maltodextrin. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria cocos powder in a weight ratio of 0.4:0.25:0.2:0.15.

[0039] This embodiment also provides a method for preparing the pet oral cleaning lozenge, including the following steps: (1) Crush the raw materials in a pulverizer and pass them through a 100-mesh sieve. Place them in an environment with a temperature of 25℃ and a relative humidity of 40% to dry them for later use. Ensure that the moisture content of the raw materials is ≤3% and the particle size is uniform to obtain the raw material pretreatment material. (2) Weigh the pretreated raw materials according to the formula, put them into a high-speed mixer, adjust the speed to 2500 r / min, and mix for 15 min to obtain the mixture; (3) Place the mixture in a tablet press, adjust the tableting pressure to 15MPa, the tableting speed to 50 tablets / minute, and press it into a thin sheet with a diameter of 10mm and a thickness of 5mm. The relative humidity of the tableting environment is 40%, and the thickness deviation of the tablet is controlled to be ≤±0.1mm. Qualified tablets are screened, and products with excessive thickness deviation or damage are removed. The tablets are individually packaged in aluminum foil, and a desiccant is placed inside the package to obtain pet oral cleaning tablets.

[0040] Example 4 The difference between this embodiment and Embodiment 2 is that the rapid-disintegration matrix is ​​composed of kudzu root powder, yam powder, coix seed powder and poria powder in a mass ratio of 0.45:0.20:0.25:0.1.

[0041] Everything else is the same as in Example 2.

[0042] Example 5 This embodiment provides a pet oral cleaning lozenge made from the following raw materials in the indicated weight percentages: 52% rapid-disintegrating matrix, 1.5% lysozyme, 4% tea polyphenols, 1.0% DL-panthenol, 0.8% vitamin C, 1.5% licorice extract, 2.5% peppermint extract, 1.5% honeysuckle extract, 0.5% cactus extract, 0.5% ophiopogon japonicus extract, 0.7% trace elements, 2.5% amino acids, 6.5% natural fish extract, and 24.5% maltodextrin. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria cocos powder in a weight ratio of 0.4:0.25:0.2:0.15.

[0043] The pet oral cleaning lozenges were prepared according to the preparation method of Example 2.

[0044] Comparative Example 1 The difference between this comparative example and Example 2 is that the rapid-disintegrating matrix is ​​a combination of microcrystalline cellulose, cross-linked polyvinylpyrrolidone and low-substituted hydroxypropyl cellulose, and the mass ratio of the three is 1:1:1.

[0045] Everything else is the same as in Example 2.

[0046] Comparative Example 2 The difference between this comparative example and Example 2 is that the rapid-disintegration matrix does not contain kudzu root powder, while the rest are the same as in Example 2.

[0047] Comparative Example 3 The difference between this comparative example and Example 2 is that the rapid-disintegration matrix does not contain yam powder, while the rest are the same as in Example 2.

[0048] Comparative Example 4 The difference between this comparative example and Example 2 is that the rapid-disintegration matrix does not contain coix seed powder, while all other aspects are the same as in Example 2.

[0049] Comparative Example 5 The difference between this comparative example and Example 2 is that the rapid-disintegration matrix does not contain Poria cocos powder, while the rest are the same as in Example 2.

[0050] Comparative Example 6 The difference between this comparative example and Example 2 is that the Poria cocos powder in the rapid-disintegration matrix is ​​replaced with lotus seed powder without the core, while the rest is the same as in Example 2.

[0051] Comparative Example 7 The difference between this comparative example and Example 2 is that the rapid-disintegration matrix is ​​52% kudzu root powder (that is, it does not contain yam powder, coix seed powder and poria powder), and the rest are the same as in Example 2.

[0052] Comparative Example 8 The difference between this comparative example and Example 2 is that the kudzu root powder, yam powder, coix seed powder and poria powder are composed in a mass ratio of 0.2:0.15:0.4:0.15.

[0053] The pet oral cleaning lozenges prepared in Examples 1-5 and Comparative Examples 1-8 were tested for storage stability, hardness, disintegration time and disintegration rate. The test methods are as follows, and the test results are shown in Table 1.

[0054] Storage stability: The pet oral cleaning tablets prepared in the examples and comparative examples were stored in a sealed environment for 24 months to observe whether moisture absorption or disintegration occurred.

[0055] Hardness: Take 10 pet oral cleaning lozenges prepared in each example and comparative example, according to the General Rules of Part IV of the 2025 edition of the Chinese Pharmacopoeia, record the unit area pressure when the lozenge breaks as the hardness, and take the average value.

[0056] Comprehensive evaluation of disintegration behavior: Artificial feline saliva (or CatSaliva (BZ301)) was equilibrated in a constant temperature water bath at 37±0.5℃. Thirteen 10 mL portions of artificial feline saliva were added to thirteen 50 mL beakers. A single tablet was tested in each beaker, and the disintegration time, disintegration product state, and disintegration rate were measured.

[0057] Disintegration time: Gently place a single lozenge (one of Examples 1-5 and Comparative Examples 1-8) on the liquid surface, start timing immediately, and observe the disintegration of the lozenge. When no disintegration is observed by the naked eye after gentle stirring, the disintegration is considered complete, and the time at this time is recorded as the disintegration time. State of disintegration products: After disintegration, visually inspect the disintegration products for hard, insoluble particles. Check for adhesion, binding, or failure to disintegrate. Disintegration rate: Accurately weigh the initial mass W0 of a single lozenge (choose one from Examples 1-5 and Comparative Examples 1-8), place the lozenge in artificial simulated saliva to disintegrate, filter it through a 0.45 μm aqueous filter membrane, and wash it twice with 2 mL of 4°C cold water. Place the filter membrane and the residue in a 60°C vacuum drying oven to constant weight, and weigh the residue W. r Meanwhile, single lozenges from each embodiment and comparative example were soaked in artificial simulated saliva for 60 minutes, and the insoluble substance content W was obtained according to the aforementioned method. b The disintegration rate is calculated using the following formula.

[0058] Disintegration rate = (W0 - W) r ) / (W0-W b ) × 100% The aforementioned disintegration behavior was comprehensively evaluated by testing each embodiment and comparative example five times, and the average value was taken.

[0059] Table 1. Performance test results of pet oral cleaning lozenges in the examples and comparative examples.

[0060] As can be seen from the test results in Table 1, compared with Comparative Examples 1-8, Examples 1-5 of the present invention have better overall storage stability, hardness, shorter disintegration time and active ingredient release rate. This also shows that the combination of kudzu root powder, yam powder, coix seed powder and poria powder of the present invention in a specific ratio can achieve rapid disintegration, and make the lozenges of the present invention have better hardness and storage stability. At the same time, it can also effectively promote the disintegration and release of each active ingredient and improve the disintegration rate.

[0061] Test case 1. Test materials Test sample: Pet oral cleaning lozenges prepared in Examples 2 and 5 of this invention.

[0062] Control sample: Basic refreshing lozenges (thin sheets with a diameter of 9 mm and a thickness of 4 mm, made from mannitol 50%, microcrystalline cellulose 29.9%, pregelatinized starch 10%, croscarmellose sodium 7%, croscarmellose 3% and menthol 0.1%) Experimental animals: 40 healthy adult Bichon Frises and 40 British Shorthair cats, weighing 2-7 kg, all with mild to moderate halitosis and dental plaque, but no severe periodontal disease or oral ulcers.

[0063] Trial period: Feed one tablet daily for 28 consecutive days, placed at the base of the pet's tongue and allowed to dissolve naturally.

[0064] 2. Experimental Grouping Eighty pets were divided into four groups (10 Bichon Frises and 10 British Shorthair cats in each group), designated as Experimental Group 1, Experimental Group 2, Control Group, and Blank Group. Experimental Group 1 and Experimental Group 2 were fed the oral cleaning lozenges of Example 2 and Example 5 of this invention, respectively. The Control Group was fed basic freshening lozenges, and the Blank Group was not given any oral cleaning products.

[0065] 3. Detection Indicators and Methods Fresh breath test: Before feeding on day 28, the oral volatile sulfur compound (VSC, ppm) content was measured using a breath analyzer. Then feeding was carried out. After feeding, the oral volatile sulfur compound (VSC, ppm) content was measured every hour. Improvement rate = (content before feeding - content after 8 hours of feeding) / content before feeding × 100%. The results are shown in Table 2.

[0066] Dental plaque inhibition effect: Basic fuchsin staining + ImageJ analysis, dental plaque coverage (%) was measured weekly, and the improvement rate = (dental plaque coverage before feeding - dental plaque coverage after four weeks of feeding) / dental plaque coverage before feeding × 100%. The results are shown in Table 3.

[0067] Gum health status: 0~5 grade (the lower the score, the better). The redness, bleeding and sensitivity are assessed weekly by a professional veterinarian. Improvement rate = (gingival score before feeding - gingival score after four weeks of feeding) / gingival score before feeding × 100%. The results are shown in Table 4.

[0068] Table 2. Test results of VSC content in each group

[0069] Table 3. Plaque coverage rate of each group

[0070] Table 4. Gingival health scores for each group

[0071] As shown in Tables 2-4, the pet oral hygiene lozenges of the present invention have excellent breath-freshening effects, effectively reducing the content of volatile sulfur compounds in the oral cavity, with an improvement rate of 43.2%-48.6%, far higher than the control group (20.2%) and the blank group (-3.8%). They can effectively remove dental plaque and inhibit its formation, with a plaque improvement effect of 57.8%-59.6%, far higher than the control group (29.1%) and the blank group (-17.6%). Simultaneously, they can effectively improve gum health, with a gum-protecting effect far superior to the control group and the blank group. This indicates that the pet oral hygiene lozenges of the present invention have excellent effects in cleaning teeth, protecting gums, and freshening breath.

[0072] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, it is not limited to those listed in the embodiments. Those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A pet oral cleaning lozenge, characterized in that, It is made from the following raw materials in the following mass percentages: 48%~55% rapid-disintegrating matrix, 1%~2% lysozyme, 3%~5% tea polyphenols, 0.5%~1% DL-panthenol, 0.5%~1% vitamin C, 1%~2% licorice extract, 2%~3% peppermint extract, 0.5%~2% honeysuckle extract, 0~1% cactus extract, 0~1% ophiopogon japonicus extract, 2.5%~4% nutrients, 5%~8% flavor modifiers, and the balance being fillers. The rapid-disintegrating matrix is ​​composed of kudzu root powder, yam powder, coix seed powder, and poria cocos powder, and the mass ratio of kudzu root powder, yam powder, coix seed powder, and poria cocos powder is 0.3~0.5:0.2~0.3:0.1~0.3:0.1~0.

2.

2. The pet oral cleaning lozenge according to claim 1, characterized in that, The mass ratio of the kudzu root powder, the yam powder, the coix seed powder, and the poria powder is 0.4:0.25:0.2:0.

15.

3. The pet oral cleaning lozenge according to claim 1, characterized in that, The enzyme activity of the lysozyme is not less than 20,000 U / mg.

4. The pet oral cleaning lozenge according to claim 1, characterized in that, The purity of the tea polyphenols is not less than 98%, and the purity of the DL-panthenol is not less than 95%.

5. The pet oral cleaning lozenge according to claim 1, characterized in that, The filler is maltodextrin, the nutritional components include at least one of trace elements and amino acids, and the flavor modifier includes at least one of natural chicken extract and natural fish extract.

6. The pet oral cleaning lozenge according to claim 1, characterized in that, The diameter is 5mm~10mm, the thickness is 3mm~5mm, the hardness is 9MPa~16MPa, and the disintegration time is 15s~30s.

7. The method for preparing pet oral cleaning lozenges according to any one of claims 1 to 6, characterized in that, Including the following steps: (1) The raw materials are crushed, sieved, and dried to obtain raw material pretreatment material; (2) Weigh out the pre-treated raw materials according to the formula and mix them evenly to obtain a mixture; (3) The mixture is compressed into tablets.

8. The method for preparing pet oral cleaning lozenges according to claim 7, characterized in that, Step (1) specifically includes crushing the raw materials in a pulverizer and passing them through a 60-120 mesh sieve, and drying them in an environment with a temperature of 20℃-25℃ and a relative humidity of ≤40% to obtain a pre-treated raw material with a moisture content of no more than 3%.

9. The method for preparing pet oral cleaning lozenges according to claim 7, characterized in that, In step (2), the mixing is carried out in a mixer at a speed of 2000 r / min to 2500 r / min for a time of 10 min to 30 min.

10. The method for preparing pet oral cleaning lozenges according to claim 7, characterized in that, In step (3), the tableting process is carried out in a tablet press, the tableting pressure is 10MPa~16MPa, and the tableting speed is 30~50 tablets / minute.

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