Intelligent configuration device for biological anti-tumor experimental drugs

Abstract

The application discloses a kind of biological anti-tumor experimental drug intelligent configuration device, belong to biomedical technology field, the present application includes shell and the closed block of sliding installation in the front side of the shell, the shell is opened with medicine outlet, the inside of the shell is fixed with containing block, and the middle part of containing block is provided with the carrying area, the carrying area is used to place capsule, and the left and right sides of carrying area are powder area, the lower end of powder area is connected with suction channel, suction channel is used to suck the medicine powder in powder area, the inside of powder area is provided with separation kit, and separation kit is used to split capsule.The biological anti-tumor experimental drug intelligent configuration device, by setting the symmetrical distribution separation kit, the two ends of capsule are wrapped and limited by separation kit, the capsule is automatically separated by the relative movement of separation kit, the internal medicine powder is scattered, to prevent the generation of small skin chips.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to an intelligent preparation device for experimental biological anti-tumor drugs. Background Technology

[0002] With the rapid development of molecular targeted therapy and immunotherapy, the routes of administration for anti-tumor drugs are also constantly being innovated. Inhalation, as a non-invasive local drug delivery method, can deliver drugs directly to the lung tumor site, achieving high drug concentration accumulation at the lesion site, while significantly reducing systemic toxic side effects. Dry powder inhalers, as an important inhalation drug delivery device, have advantages such as painless, rapid, precise, and direct drug delivery. Compared with oral and injection drug delivery methods, inhaled dry powder drug delivery can bypass gastrointestinal degradation and first-pass metabolism in the liver, achieving efficient drug delivery.

[0003] For example, a tumor experimental drug preparation device with publication number CN120478786A includes an inhaler for preparing and administering dry powder tumor drugs. The inhaler includes a housing, and a partition is fixed inside the housing. The housing is divided by the partition to form a preparation chamber and a processing chamber. The preparation chamber is located above the processing chamber. An inhalation tube is fixed on the housing. One end of the inhalation tube is installed and fixed to the bottom of the partition. Through the preparation function of the inhaler, a quantitative amount of anti-tumor drugs is directly delivered to the tumor site in the lungs of the human body. During the use of the inhaler, the tumor experimental drugs after cutting are fully separated and partial spillage is inhibited through the cooperation of the cutting and releasing component, the anti-overflow communication component and the air intake control component. The existing technologies mentioned above have the following technical problems: When releasing powder from inside a capsule, the existing drug preparation device usually uses cutting or puncturing the capsule. However, whether cutting or puncturing, it is easy to cause some small epidermal debris to be generated from the capsule. When the debris is inhaled by the patient, it can easily interfere with the patient's treatment. At the same time, the puncture method is also easy to cause difficulty in the subsequent inhalation of the powder due to the small size of the puncture hole.

[0004] Therefore, we propose an intelligent preparation device for experimental biological anti-tumor drugs to address the problems mentioned above. Summary of the Invention

[0005] The purpose of this invention is to provide an intelligent preparation device for experimental biological anti-tumor drugs, in order to solve the problem mentioned in the background art. Currently available drug preparation devices on the market typically release powder from capsules by cutting or piercing them. However, whether cutting or piercing, it is easy to cause some fine epidermal debris to be generated from the capsule. When the debris is inhaled by the patient, it can easily interfere with the patient's treatment. At the same time, the piercing method is also prone to problems such as difficulty in subsequent powder inhalation due to the small piercing hole.

[0006] To achieve the above objectives, the present invention provides the following technical solution: an intelligent preparation device for experimental biological anti-tumor drugs, comprising an outer shell and a sealing block slidably mounted on the front side of the outer shell, the outer shell having a drug dispensing port, a receiving block fixed inside the outer shell, and a loading area in the middle of the receiving block, the loading area being used to place capsules, and the left and right sides of the loading area being powder dropping areas, the lower end of the powder dropping area being connected to a drug suction channel for sucking up the drug powder in the powder dropping area, and a separation kit being provided inside the powder dropping area for disassembling the capsules.

[0007] Preferably, the powder-falling area and the drug-absorption channel are interconnected, and a negative pressure sensor is installed on the side of the drug-absorption channel, with the detection end of the negative pressure sensor extending into the interior of the drug-absorption channel.

[0008] By adopting the above technical solution, the negative pressure sensor can be set up to intelligently detect the suction strength and remind patients to use sufficient suction to draw out the powder.

[0009] Preferably, the separation kit includes a movable column inserted into the powder-falling area, and an adjustment frame is fixedly connected to one end of the movable column outside the powder-falling area. The upper end of the adjustment frame is connected to a power plate via a first spring, and an assisting pressure plate is fixed to the upper end of the power plate. The assisting pressure plate can slide on the outer shell, and the assisting pressure plate is connected to the outer shell via a second spring.

[0010] By adopting the above technical solution, the sliding of the assisting pressure plate on the outer shell can drive the power plate to move synchronously. The second spring facilitates the reset of the assisting pressure plate after movement.

[0011] Preferably, the spring constant of the first spring is greater than that of the second spring, and the power plate can slide on the adjustment frame.

[0012] By adopting the above technical solution, and through the difference in stiffness coefficients of the first spring and the second spring, when the pressure plate moves, the power plate and the adjusting frame can be pushed to move synchronously first. When the adjusting frame moves to its limit, the power plate moves on the adjusting frame.

[0013] Preferably, a central screw is installed in the middle of the moving column, and one end of the central screw extending into the interior of the moving column is rotatably connected to the piston block. The piston block is located in the air guiding chamber inside the moving column, and the air guiding chamber is connected to each other through an air supply hose and a positioning rubber sleeve. The positioning rubber sleeve is located inside the snap-fit ​​cover, and the snap-fit ​​cover is rotatably connected to the end of the moving column through a rotating shaft. A torsion spring that provides a reset elastic force is installed on the rotating shaft of the snap-fit ​​cover.

[0014] By adopting the above technical solution, the airflow inside the guide air chamber is forced into the interior of the positioning rubber sleeve, thereby causing the positioning rubber sleeve to expand.

[0015] Preferably, the central screw and the moving column are connected by a thread at their middle parts, and the piston block rotatably connected to the end of the central screw is wrapped with a sealing ring on its outer wall, and the piston block can slide inside the air guiding chamber.

[0016] By adopting the above technical solution, when the central screw rotates on the moving column, it can push the piston block to move. The sealing ring wrapped around the outer wall of the piston block can improve the sealing between the piston block and the inside of the guide air chamber.

[0017] Preferably, the interior of the positioning sleeve is hollow, the longitudinal section of the positioning sleeve is annular, and the inner ring surface of the positioning sleeve is roughened.

[0018] By adopting the above technical solution, the annular structure of the longitudinal section of the positioning sleeve facilitates the wrapping of the capsule, and the rough surface of the inner ring of the positioning sleeve can improve the contact friction with the capsule.

[0019] Preferably, the upper end of the snap-fit ​​cover is fixed with a protrusion, and a pressing post is provided above the protrusion. A vertical rod is inserted into the middle of the pressing post, and the vertical rod is connected to the pressing post through a return spring. The lower end of the pressing post and the upper end of the vertical rod are both set as arc-shaped structures.

[0020] By adopting the above technical solution, the arc shape at the lower end of the pressing column is used to squeeze the protrusion after the snap-fit ​​cover moves, causing the snap-fit ​​cover to rotate and tilt downwards.

[0021] Preferably, the upper end of the vertical insertion rod is provided with a plurality of pressure blocks fixed to the lower surface of the power plate, and the longitudinal section of the pressure blocks is also set to be arc-shaped, so that the vertical insertion rod can slide on the pressure column.

[0022] By adopting the above technical solution, the vertical insertion rod can be intermittently squeezed by the pressure block through the movement of the power plate, so that the vertical insertion rod can move up and down reciprocally.

[0023] Compared with the prior art, the beneficial effects of the present invention are: the intelligent preparation device for biological anti-tumor experimental drugs, by setting symmetrically distributed separation kits, uses the separation kits to wrap and limit the two ends of the capsule, and automatically separates the capsule by the relative movement of the separation kits, allowing the internal drug powder to scatter and preventing the generation of fine epidermal debris; 1. By moving the piston block inside the air guide chamber of the moving column, the airflow inside the air guide chamber can be squeezed through the air delivery hose into the positioning sleeve. The expansion of the positioning sleeve after inflation can wrap and limit the end of the capsule. By moving the moving column, the two ends of the capsule can be automatically separated, which makes it easier for the patient to inhale the powder inside the capsule and avoids the need for puncture or cutting, which would cause some small capsule skin. 2. The pressure column can squeeze the protrusion on the snap-fit ​​cover, causing it to rotate downwards to an inclined position. After the snap-fit ​​cover rotates to the inclined position, the separated capsule also rotates synchronously. The inclined capsule makes it easier for the powder inside to fall out. At the same time, the reciprocating movement of the vertical rod on the pressure column can make the snap-fit ​​cover shake slightly. The shaking of the snap-fit ​​cover can also accelerate the falling of the powder, preventing the powder from accumulating inside the capsule and making it easier for the patient to inhale. Attached Figure Description

[0024] Figure 1 This is a frontal perspective view of the present invention; Figure 2 This is a schematic diagram of the structure of the sealing block of the present invention after it slides open on the outer shell; Figure 3 This is a schematic diagram of the front cross-sectional structure of the present invention; Figure 4 This is a schematic diagram of the structure of the loading area and the powder dropping area of ​​the present invention; Figure 5 This is a schematic diagram of the movable column and snap-fit ​​cover structure of the present invention; Figure 6 This is a schematic diagram of the positioning sleeve and snap-fit ​​cover structure of the present invention; Figure 7 For the present invention Figure 3 Enlarged structural diagram at point A in the middle; Figure 8 This is a schematic diagram of the power plate and vertical insertion rod structure of the present invention; Figure 9 For the present invention Figure 8 Enlarged structural diagram at point B.

[0025] In the diagram: 1. Outer shell; 2. Sealing block; 3. Dispensing port; 4. Container block; 5. Loading area; 6. Powder dropping area; 7. Separation kit; 701. Moving column; 702. Adjusting frame; 703. Power plate; 704. First spring; 705. Assisting pressure plate; 706. Second spring; 707. Central screw; 708. Piston block; 709. Guide air chamber; 7010. Air delivery hose; 7011. Positioning sleeve; 7012. Snap-fit ​​cover; 7013. Protrusion; 8. Suction channel; 9. Negative pressure sensor; 10. Pressure column; 11. Vertical insertion rod; 12. Return spring; 13. Pressure block. Detailed Implementation

[0026] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] Example 1: Please refer to Figures 1-9Existing drug preparation devices typically release powder from capsules by cutting or piercing them. However, both cutting and piercing can easily cause small epidermal debris to be generated from the capsule. When this debris is inhaled by the patient, it can interfere with treatment. Furthermore, piercing can result in small holes, making subsequent powder inhalation difficult. To address this technical problem, this embodiment discloses the following technical content: an intelligent preparation device for biological anti-tumor experimental drugs, including a shell 1 and a sealing block 2 slidably mounted on the front side of the shell 1. The shell 1 has a drug dispensing port 3, and a receiving block 4 is fixed inside the shell 1, containing... Block 4 has a loading area 5 in the middle for placing capsules. The left and right sides of the loading area 5 are powder dropping areas 6. The lower end of the powder dropping area 6 is connected to a suction channel 8 for sucking up the powder from the powder dropping area 6. A separation kit 7 is located inside the powder dropping area 6 for separating the capsules. The powder dropping area 6 and the suction channel 8 are interconnected. A negative pressure sensor 9 is installed on the side of the suction channel 8, with its detection end extending into the suction channel 8. The separation kit 7 includes a movable column 701 inserted into the powder dropping area 6. An adjusting frame 702 is fixedly connected to one end of the movable column 701 outside the powder dropping area 6. The upper end of the adjusting frame 702... A power plate 703 is connected to a first spring 704, and an assisting pressure plate 705 is fixed to the upper end of the power plate 703. The assisting pressure plate 705 can slide on the outer shell 1. The assisting pressure plate 705 is connected to the outer shell 1 through a second spring 706. The stiffness coefficient of the first spring 704 is greater than that of the second spring 706. The power plate 703 can slide on the adjusting frame 702. A central screw 707 is installed in the middle of the moving column 701, and one end of the central screw 707 that extends into the moving column 701 is rotatably connected to a piston block 708. The piston block 708 is located in the air guide chamber 709 inside the moving column 701, and the air guide chamber 709 is connected to an air delivery hose 70 10 and positioning sleeve 7011 are interconnected. Positioning sleeve 7011 is located inside snap-fit ​​cover 7012, and snap-fit ​​cover 7012 is rotatably connected to the end of moving column 701 via a rotating shaft. A torsion spring providing reset elasticity is installed on the rotating shaft of snap-fit ​​cover 7012. The center screw 707 and the middle part of moving column 701 are threadedly connected, and the piston block 708 rotatably connected to the end of center screw 707 is wrapped with a sealing ring on its outer wall. The piston block 708 can slide inside the guide air chamber 709. The interior of positioning sleeve 7011 is set as a hollow structure, and the longitudinal section of positioning sleeve 7011 is set as an annular structure. The inner ring surface of positioning sleeve 7011 is set as a rough surface.

[0028] When the capsule powder needs to be inhaled, push the sealing block 2 on the outer shell 1. After the sealing block 2 moves, the dispensing port 3 opens. At this time, push the assisting pressure plate 705 to the outside of the outer shell 1. After the assisting pressure plate 705 moves, it can drive the moving column 701 to move through the power plate 703 and the adjusting frame 702. After placing the capsule on the mounting area 5 in the middle of the receiving block 4, release the assisting pressure plate 705. After the assisting pressure plate 705 is released, it will reset under the action of the second spring 706. The snap-fit ​​cover 7012 at the end of the moving column 701 moves to the outside of the end of the capsule. Rotate the center screw 707. After the center screw 707 rotates, it can push the piston block 708 to move in the air guide chamber 709 inside the moving column 701. The movement of the piston block 708 can squeeze the airflow inside the air guide chamber 709 through the air delivery hose 7010 into the interior of the positioning sleeve 7011. After inflation, the capsule's ends are wrapped and limited. The rough surface of the positioning sleeve 7011 increases the contact friction between the positioning sleeve 7011 and the capsule. The sealing block 2 is pushed down to continue sealing the drug dispensing port 3. After wrapping and limiting both ends of the capsule, the assisting pressure plate 705 can be pushed to the outside of the outer shell 1. The movement of the assisting pressure plate 705 can drive the moving column 701 and the end snap-fit ​​cover 7012 to move synchronously. The movement of the snap-fit ​​cover 7012 can automatically separate the two ends of the capsule. Since the drug suction channel 8 and the powder drop area 6 are interconnected, the patient can inhale the drug powder in the capsule separated in the powder drop area 6 through the drug suction channel 8. By splitting the capsule, the method of cutting or puncturing the capsule is avoided, which would cause some small capsule skin to be inhaled by the patient along with the drug powder. Meanwhile, a negative pressure sensor 9 is installed on the inhalation channel 8. The negative pressure sensor 9 can intelligently detect the patient's suction power to prevent the patient from inhaling the powder incompletely due to insufficient suction power.

[0029] Example 2: The technical content disclosed in this example is a further improvement based on Example 1 described above, such as... Figure 6 and Figure 8 As shown, the following technical content is disclosed in this embodiment: a protrusion 7013 is fixed at the upper end of the snap-fit ​​cover 7012, and a pressing post 10 is provided above the protrusion 7013. A vertical insertion rod 11 is inserted into the middle of the pressing post 10, and the vertical insertion rod 11 is connected to the pressing post 10 through a reset spring 12. The lower end of the pressing post 10 and the upper end of the vertical insertion rod 11 are both set as arc-shaped structures. A plurality of pressing blocks 13 fixed to the lower surface of the power plate 703 are provided at the upper end of the vertical insertion rod 11, and the longitudinal section of the pressing block 13 is also set as arc-shaped. The vertical insertion rod 11 can slide on the pressing post 10.

[0030] When the assisting pressure plate 705 is pushed towards the outside of the outer shell 1, the assisting pressure plate 705 can drive the power plate 703 and the adjusting frame 702 to move synchronously. After the adjusting frame 702 moves, it can move the moving column 701 and the end retaining cover 7012. At this time, after the retaining cover 7012 moves, its upper protrusion 7013 is pushed by the lower end of the pressing column 10. After the retaining cover 7012 is pressed, it rotates downward. When the retaining cover 7012 rotates downward, it is convenient to pour the separated capsule powder downward. At the same time, when the adjusting frame 702 moves to the limit and touches the outer shell 1, when the assisting pressure plate 705 continues to move, it can... The power plate 703 moves on the adjusting frame 702. After the power plate 703 moves, the pressing block 13 on it can release the pressure from the vertical insertion rod 11 and push the vertical insertion rod 11 downward. After the vertical insertion rod 11 moves downward, it can push the snap-fit ​​cover 7012 downward. When the pressing block 13 and the vertical insertion rod 11 are separated, the vertical insertion rod 11 can be reset under the action of the return spring 12. At this time, the snap-fit ​​cover 7012 is also reset under the action of the torsion spring. This allows the snap-fit ​​cover 7012 to perform a small-amplitude reciprocating vibration, thereby further improving the effect of the powder falling inside the capsule after separation and preventing the powder from adhering to the inside of the capsule.

[0031] The contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0032] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A smart preparation device for experimental biological antitumor drugs, comprising an outer shell (1) and a sealing block (2) slidably mounted on the front side of the outer shell (1), wherein the outer shell (1) has a drug dispensing port (3), characterized in that: The outer shell (1) has a fixed accommodating block (4) inside, and a loading area (5) is provided in the middle of the accommodating block (4). The loading area (5) is used to place capsules, and the left and right sides of the loading area (5) are powder dropping areas (6). The lower end of the powder dropping area (6) is connected to a drug suction channel (8), which is used to suck up the drug powder in the powder dropping area (6). A separation kit (7) is provided on the inner side of the powder dropping area (6), and the separation kit (7) is used to separate the capsules.

2. The intelligent preparation device for experimental biological antitumor drugs according to claim 1, characterized in that: The powder drop area (6) and the drug absorption channel (8) are interconnected, and a negative pressure sensor (9) is installed on the side of the drug absorption channel (8), with the detection end of the negative pressure sensor (9) extending into the inside of the drug absorption channel (8).

3. The intelligent preparation device for experimental biological antitumor drugs according to claim 1, characterized in that: The separation kit (7) includes a movable column (701) inserted into the powder drop area (6), and an adjustment frame (702) is fixedly connected to one end of the movable column (701) outside the powder drop area (6). The upper end of the adjustment frame (702) is connected to a power plate (703) via a first spring (704), and an assisting pressure plate (705) is fixed to the upper end of the power plate (703). The assisting pressure plate (705) can slide on the outer shell (1), and the assisting pressure plate (705) is connected to the outer shell (1) via a second spring (706).

4. The intelligent preparation device for experimental biological antitumor drugs according to claim 3, characterized in that: The spring constant of the first spring (704) is greater than that of the second spring (706), and the power plate (703) can slide on the adjustment frame (702).

5. The intelligent preparation device for experimental biological antitumor drugs according to claim 4, characterized in that: A central screw (707) is installed in the middle of the moving column (701), and one end of the central screw (707) extending into the moving column (701) is rotatably connected to the piston block (708). The piston block (708) is located in the air guide chamber (709) inside the moving column (701), and the air guide chamber (709) is connected to each other through the air supply hose (7010) and the positioning sleeve (7011). The positioning sleeve (7011) is located inside the snap-fit ​​cover (7012), and the snap-fit ​​cover (7012) is rotatably connected to the end of the moving column (701) through a rotating shaft. A torsion spring that provides a reset elastic force is installed on the rotating shaft of the snap-fit ​​cover (7012).

6. The intelligent preparation device for experimental biological antitumor drugs according to claim 5, characterized in that: The central screw (707) and the moving column (701) are connected by a thread in the middle, and the piston block (708) rotatably connected to the end of the central screw (707) is wrapped with a sealing ring on its outer wall. The piston block (708) can slide inside the air guiding chamber (709).

7. The intelligent preparation device for experimental biological antitumor drugs according to claim 6, characterized in that: The positioning sleeve (7011) has a hollow interior and a ring-shaped longitudinal section. The inner ring surface of the positioning sleeve (7011) is roughened.

8. The intelligent preparation device for experimental biological antitumor drugs according to claim 7, characterized in that: The upper end of the snap-fit ​​cover (7012) is fixed with a protrusion (7013), and a pressing post (10) is provided above the protrusion (7013). A vertical insert (11) is inserted into the middle of the pressing post (10), and the vertical insert (11) is connected to the pressing post (10) through a return spring (12). The lower end of the pressing post (10) and the upper end of the vertical insert (11) are both set as arc-shaped structures.

9. The intelligent preparation device for experimental biological antitumor drugs according to claim 8, characterized in that: The upper end of the vertical insert (11) is provided with multiple pressure blocks (13) fixed on the lower surface of the power plate (703), and the longitudinal section of the pressure block (13) is also set to be arc-shaped, so that the vertical insert (11) can slide on the pressure column (10).

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