Targeted and controllable drug delivery device for oral mucositis induced by chemotherapy

Abstract

The application relates to the technical field of oral mucositis administration, in particular to a targeted and pasted controllable administration auxiliary device for oral mucositis caused by radiotherapy and chemotherapy, which comprises an inner rubber sleeve, a medicine storage assembly for storing liquid medicine is arranged on the surface of the inner rubber sleeve, and a connecting pipe is fixedly connected to the outer wall of the medicine storage assembly. By arranging a layered pasting administration structure, the inner rubber sleeve and the outer rubber sleeve are pasted to the inner wall of the oral cavity in a double-layered and elliptical rubber sleeve mode, and the overall device is stably pasted to the lesion by relying on the occlusal pressure of the oral cavity; the slidable plastic shell positioning assembly is matched, the administration area can be slidably adjusted according to the position of the oral mucosal ulcer and erosion of the patient, the corresponding position block is removed, and the point release of medicine is realized, the problems of the deviation of the administration site of the traditional administration device and the loss and dilution of the liquid medicine are solved, the target administration of the lesion is realized, the inner rubber sleeve and the outer rubber sleeve store the liquid medicine to continuously maintain the high drug concentration of the mucosal affected area, and the anti-inflammatory, analgesic and mucosal repair effects are improved.

Description

Technical Field

[0001] This invention relates to the field of oral mucositis drug delivery technology, specifically to a targeted and controllable drug delivery auxiliary device for oral mucositis caused by radiotherapy and chemotherapy. Background Technology

[0002] Chemotherapy and radiotherapy are core treatments for head and neck tumors and systemic malignant tumors. However, while killing tumor cells, they can severely damage the rapidly proliferating epithelial cells of the oral mucosa, disrupting the mucosal barrier structure and inducing chemotherapy-induced oral mucositis. This complication has an extremely high clinical incidence, exceeding 80% in patients receiving radiotherapy alone and over 90% in patients receiving concurrent chemoradiotherapy. It is one of the most common and challenging acute adverse reactions during cancer treatment. Currently, clinical treatment for chemoradiotherapy-induced oral mucositis mainly involves systemic and local oral administration. However, systemic oral anti-inflammatory, analgesic, and restorative drugs have significant limitations. After systemic metabolism, the drug concentration at the oral lesion is low, resulting in poor targeting and limited therapeutic effect. Furthermore, long-term use can increase the metabolic burden on the liver and kidneys, increasing the risk of systemic adverse reactions. Therefore, these drugs are not suitable for cancer patients who are physically weak during chemoradiotherapy.

[0003] For example, a self-administered oral mucosa drug delivery device with publication number CN118949247A can concentrate the drug to the affected mucosa for targeted treatment, avoiding the drug's effectiveness from being affected by microorganisms and enzymes in saliva. Furthermore, it can perform periodic self-administered drug delivery based on the patient's active operation, enhancing the treatment effect on the oral affected area. However, the drug delivery tube is not stably fixed, which can easily cause the released drug solution to deviate from the affected area during the patient's wearing and drug delivery process. This can easily lead to drug dilution and reduced concentration, or drug loss from the affected area, resulting in the failure to achieve the expected therapeutic effect. Summary of the Invention

[0004] To address the problems in the prior art, this invention provides a targeted, adhesive, and controllable drug delivery aid for oral mucositis caused by radiotherapy and chemotherapy.

[0005] The technical solution adopted by the present invention to solve its technical problem is: a targeted and controllable drug delivery auxiliary device for oral mucositis caused by radiotherapy and chemotherapy, including an inner rubber sleeve, a drug storage component for storing drug solution is provided on the surface of the inner rubber sleeve, a connecting tube is fixedly connected to the outer wall of the drug storage component, a positioning component for positioning the drug delivery position is movably sleeved on the surface of the drug storage component, a drug delivery component for releasing drug solution is movably sleeved on the surface of the positioning component, a drug addition component for adding drug solution to the drug storage component is snapped to the other end of the connecting tube, and an adjustment component for controlling the flow of drug solution is provided inside the drug addition component; The drug storage assembly includes an outer rubber sleeve, which is fixedly fitted onto the surface of an inner rubber sleeve, and the surface of the outer rubber sleeve has multiple strip-shaped openings. The positioning component includes a plastic shell, which is slidably fitted onto the surface of an outer sleeve. Multiple through holes are arrayed on the surface of the plastic shell, and plugs are engaged inside the through holes. The drug delivery component includes a coating gel, which is fitted onto the surface of a plastic shell, and the surface of the coating gel has multiple fine pores.

[0006] Specifically, the plurality of strip-shaped openings correspond to the plurality of through holes, and the plurality of through holes correspond to the plurality of fine holes.

[0007] Specifically, both the outer and inner rubber sleeves have elliptical surfaces, and a gap is provided between them.

[0008] Specifically, the dosing assembly includes a medicine box, a rubber tube fixedly connected to the lower side wall of the medicine box, the rubber tube being snapped into the inside of the connecting tube, a blocking plate fixedly connected to the inner wall of the rubber tube, a round hole being formed on the surface of the blocking plate, a rubber sealing plate being snapped into the upper end of the medicine box, and an air hole being formed at the center of the rubber sealing plate.

[0009] Specifically, the adjustment component includes a rotating shaft rotatably connected to the surface of the medicine box. One end of the rotating shaft is fixedly connected to a rotating block, which fits against the blocking plate. The surface of the rotating block has a groove corresponding to the circular hole. A fixing sleeve is fixedly fitted onto the surface of the rotating shaft. A rotating strip is fixedly connected to the end of the rotating shaft located outside the medicine box. Two fixing strips are fixedly connected to the surface of the medicine box, and the fixing strips are arranged at right angles around the rotating shaft.

[0010] Specifically, one end of the fixing sleeve is fitted with the rotating block, and the other end of the fixing sleeve is fitted with the inner wall of the medicine box.

[0011] The beneficial effects of this invention are: (1) The radiotherapy and chemotherapy oral mucositis targeted adhesive controllable drug delivery auxiliary device of the present invention, by setting a layered adhesive drug delivery structure, the inner and outer double-layered elliptical rubber sleeves are attached to the inner wall of the oral cavity, and the overall device is stably attached to the lesion by relying on the oral occlusal pressure; with the sliding plastic shell positioning component, the drug delivery area can be adjusted according to the location of the patient's oral mucosal ulcers and erosions, and the corresponding block can be removed to release the drug at the point, which solves the problems of drug delivery site deviation and drug loss and dilution of traditional drug delivery devices, and realizes targeted drug delivery to the lesion. The drug stored in the inner and outer rubber sleeves continuously maintains a high drug concentration in the mucosal lesion, and improves the anti-inflammatory, analgesic and mucosal repair effects. (2) The targeted and controllable drug delivery auxiliary device for oral mucositis caused by radiotherapy and chemotherapy described in this invention achieves drug filling through the drug delivery component and adjustment component. Rotating the external rotating strip drives the rotating block to rotate, and adjusting the overlapping area of ​​the groove and the circular hole of the plug plate can deliver drug to the inner and outer rubber sleeves without removing the device for secondary drug delivery, ensuring uniform and continuous drug delivery. It eliminates the need for patients to repeatedly add drugs themselves and is suitable for long-term use by weak patients undergoing radiotherapy and chemotherapy. (3) The targeted and controllable drug delivery auxiliary device for oral mucositis caused by radiotherapy and chemotherapy described in this invention adopts a three-layer interconnected drug release channel. The outer rubber sleeve strip opening, the plastic shell through hole, and the coating gel fine hole correspond one-to-one. The coating gel directly adheres to the damaged mucosa. The gel matrix can isolate saliva rinsing and reduce the degradation of drug by salivary enzymes. The plug can be disassembled and installed as needed. The drug release channel is opened only for the lesion area, while the healthy mucosa area is closed, avoiding large-area waste of drugs, reducing the total amount of drugs used, and reducing local drug irritation and discomfort. Attached Figure Description

[0012] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0013] Figure 1 This is a schematic diagram of the targeted and controllable drug delivery auxiliary device for oral mucositis treated with radiotherapy and chemotherapy provided by the present invention. Figure 2 A schematic cross-sectional view of the targeted, adhesive, and controllable drug delivery aid device for oral mucositis treated with radiotherapy and chemotherapy provided by this invention. Figure 1 ; Figure 3 A schematic diagram of the drug storage component of the targeted and controllable drug delivery auxiliary device for oral mucositis treated with radiotherapy and chemotherapy provided by the present invention. Figure 4 A schematic diagram of the positioning component structure of the targeted and controllable drug delivery auxiliary device for oral mucositis treated with radiotherapy and chemotherapy provided by the present invention; Figure 5 A schematic diagram of the drug delivery component structure of the targeted, adhesive, and controllable drug delivery auxiliary device for oral mucositis treated with radiotherapy and chemotherapy provided by the present invention; Figure 6 This is a schematic diagram of the drug delivery component of the targeted, adhesive, and controllable drug delivery auxiliary device for oral mucositis treated with radiotherapy and chemotherapy provided by the present invention; Figure 7 This is a schematic diagram of the adjustment component structure of the targeted and controllable drug delivery auxiliary device for oral mucositis treated with radiotherapy and chemotherapy provided by the present invention.

[0014] In the diagram: 1. Inner rubber sleeve; 2. Drug storage component; 21. Outer rubber sleeve; 22. Strip-shaped opening; 3. Connecting tube; 4. Positioning component; 41. Plastic shell; 42. Through hole; 43. Block; 5. Drug application component; 51. Coated gel; 52. Fine hole; 6. Drug dosing component; 61. Drug box; 62. Rubber tube; 63. Blocking plate; 64. Round hole; 65. Rubber sealing plate; 66. Air hole; 7. Adjustment component; 71. Rotating shaft; 72. Rotating block; 73. Groove; 74. Fixing sleeve; 75. Rotating strip; 76. Fixing strip. Detailed Implementation

[0015] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0016] Please see Figures 1 to 7 The present invention provides the following technical solutions: Example 1: A targeted, adhesive, and controllable drug delivery auxiliary device for oral mucositis caused by radiotherapy and chemotherapy, comprising an inner rubber sleeve 1, a drug storage component 2 for storing drug solution is provided on the surface of the inner rubber sleeve 1, a connecting tube 3 is fixedly connected to the outer wall of the drug storage component 2, a positioning component 4 for positioning the drug delivery position is movably sleeved on the surface of the drug storage component 2, a drug delivery component 5 for releasing drug solution is movably sleeved on the surface of the positioning component 4, and a drug addition component 6 for adding drug solution to the drug storage component 2 is snapped at the other end of the connecting tube 3, and an adjustment component 7 for controlling the flow of drug solution is provided inside the drug addition component 6; The drug storage component 2 includes an outer rubber sleeve 21, which is fixedly fitted onto the surface of the inner rubber sleeve 1. Multiple strip-shaped openings 22 are provided on the surface of the outer rubber sleeve 21. Both the inner rubber sleeve 1 and the outer rubber sleeve 21 are made of medical-grade flexible silicone material. Their outlines are designed to be elliptical according to the shape of the human oral vestibule. A closed hollow drug storage cavity is formed in the middle of the double rubber sleeves, which can store therapeutic liquids for anti-inflammatory, analgesic, and repair purposes of the oral mucosa. The strip-shaped openings 22 distributed on the surface of the outer rubber sleeve 21 serve as the first delivery channel for the liquid to permeate outward. The positioning component 4 includes a plastic shell 41, which is slidably fitted onto the surface of the outer sleeve 21. Multiple through holes 42 are arrayed on the surface of the plastic shell 41, and a plug 43 is snapped into the inside of the through holes 42. The plastic shell 41 is made of medical-grade hard and safe plastic and can slide and adjust the area arbitrarily along the outer wall of the outer sleeve 21. The plug 43 is made of medical-grade silicone and can be freely inserted and removed. Removing the plug 43 at the corresponding position of the lesion will open the drug release channel. The area where the plug 43 is retained will be completely sealed to block the leakage of the drug solution and achieve targeted drug delivery only to the ulcer wound. The drug delivery component 5 includes a coating gel 51, which is fitted onto the surface of the plastic shell 41. The surface of the coating gel 51 has multiple fine pores 52. The coating gel 51 is soft and moist, and can closely adhere to the damaged oral mucosa. The gel matrix can isolate the rinsing of saliva and block the enzymes in saliva from decomposing the drug solution. The fine pores 52 on the surface of the gel serve as the terminal channels for the drug solution to contact the mucosa, and continuously and stably deliver the drug to the wound.

[0017] Multiple strip-shaped openings 22 correspond to multiple through holes 42, and multiple through holes 42 correspond to multiple fine holes 52. The three are aligned to form a continuous three-layer drug release pathway, ensuring that the drug in the storage cavity can be directionally penetrated to the target mucosal area. Drug can seep out normally in areas without blockage 43, while drug is completely intercepted in areas with blockage 43.

[0018] Both the outer rubber sleeve 21 and the inner rubber sleeve 1 have elliptical surfaces. There is a gap between the outer rubber sleeve 21 and the inner rubber sleeve 1, which forms an independent drug storage cavity. The pressure generated by the patient's upper and lower jaws biting together makes the double-layered rubber sleeves fit tightly against the inner wall of the oral cavity, fixing the entire device from displacement. At the same time, the biting pressure can help push the liquid medicine in the storage cavity to be transported outward.

[0019] The dosing assembly 6 includes a medicine box 61. A rubber tube 62 is fixedly connected to the lower side wall of the medicine box 61. The rubber tube 62 is snapped into the inside of the connecting tube 3. A blocking plate 63 is fixedly connected to the inner wall of the rubber tube 62. A round hole 64 is opened on the surface of the blocking plate 63. A rubber sealing plate 65 is snapped into the upper end of the medicine box 61. An air hole 66 is opened at the center of the rubber sealing plate 65. The medicine box 61 is used to store spare treatment liquid. The rubber tube 62 is sealed and snapped into the connecting tube to achieve passage communication. The round hole 64 of the blocking plate 63 is the liquid flow channel. The air hole 66 on the rubber sealing plate 65 balances the air pressure inside and outside the medicine box 61, ensuring that the liquid flows smoothly downward into the storage chamber.

[0020] The adjusting component 7 includes a rotating shaft 71, which is rotatably connected to the surface of the medicine box 61. One end of the rotating shaft 71 is fixedly connected to a rotating block 72, which fits against the blocking plate 63. The surface of the rotating block 72 has a groove 73 corresponding to the round hole 64. A fixing sleeve 74 is fixedly fitted onto the surface of the rotating shaft 71. A rotating strip 75 is fixedly connected to the end of the rotating shaft 71 located outside the medicine box 61. Two fixing strips 76 are fixedly connected to the surface of the medicine box 61. The fixing strips 76 are set at right angles around the rotating shaft 71. When the operator rotates the outer rotating strip 75, the inner rotating block 72 can be rotated, changing the overlapping area of ​​the groove 73 and the round hole 64 on the blocking plate 63. This allows for stepless adjustment of the flow rate of the medicine liquid. The larger the overlapping area, the faster the medicine liquid is delivered. If they are completely misaligned, the medicine liquid passage is completely closed.

[0021] One end of the fixed sleeve 74 is in contact with the rotating block 72, and the other end of the fixed sleeve 74 is in contact with the inner wall of the medicine box 61. The fixed sleeve 74 provides a limiting support for the rotating shaft 71, preventing the rotating block 72 from shifting or leaking, and ensuring the sealing and stability of the flow regulation structure.

[0022] In use, slide the plastic shell 41 onto the outside of the outer sleeve 21. Move the plastic shell 41 to the corresponding area according to the location of the patient's oral mucositis lesion. Manually remove the plug 43 inside the through hole 42 at the lesion location. Leave the plug 43 in place to seal the other through holes 42, thus defining the targeted drug release area. Completely attach the coating gel 51 to the outside of the plastic shell 41, completing the assembly of the three-layer main body structure of the drug storage component 2, positioning component 4, and drug delivery component 5, ensuring the proper fit of the strip-shaped opening 22 and the through hole 42. With the three channels of the fine hole 52 aligned and connected, the drug delivery component 6 is not yet installed. The therapeutic solution is filled into the drug storage chamber between the inner rubber sleeve 1 and the outer rubber sleeve 21 through the port of the connecting tube 3. After injection, the residual solution at the port of the connecting tube is wiped clean. The rubber tube 62 is aligned with the connecting tube 3 and snapped in place, thus connecting the drug box 61 to the drug storage chamber. Then, sufficient reserve solution is filled into the drug box 61, and the rubber sealing plate 65 is closed. In the initial state, the rotating bar 75 is moved to the fully closed position, and the rotating block 72 is fully engaged. The circular hole 64 of the fully sealed blocking plate 63 blocks the supply of liquid from the drug cartridge 61 to the drug storage cavity. The entire device is placed in the patient's mouth, with the inner rubber sleeve 1 fitting the tongue and the device secured by the occlusion of the upper and lower jaws. The outer layer of gel 51 adheres tightly to the mucosal erosion surface. Rotating the rotating strip 75 opens the liquid channel, allowing the liquid to continuously permeate from the drug storage cavity through the three-layer channel to the lesion surface. The gel prevents saliva from washing away the liquid, maintaining a stable local drug concentration. During continuous wear and administration of the device, the liquid inside the drug storage cavity is continuously consumed and its volume decreases. When the medication is administered, the outer rotating bar 75 is directly turned to increase the overlapping area of ​​the groove 73 and the round hole 64. The prepared medicine in the medicine box 61 flows into the medicine storage chamber through the rubber tube 62 and the connecting tube 3 under the action of air pressure balance to complete the medication replenishment. After the medication is administered, the rotating bar 75 is turned to the fully closed position, the oral device is removed, the rubber tube 62 and the connecting tube 3 are separated, the covering gel 51 and the plastic shell 41 are removed in sequence, the residual liquid in the medicine storage chamber is drained, and each component is disassembled for cleaning and disinfection. The covering gel 51 can be replaced once.

[0023] Example 2: The technical solution in this example, which differs from Example 1, includes: a thin silicone anti-slip pad integrally molded on the inner side of the plastic shell 41. The thickness of the silicone anti-slip pad is controlled at 0.3mm, and it is soft with a high coefficient of friction. It fits tightly against the outer wall of the outer sleeve 21. After the plastic shell 41 is slidably adjusted to the corresponding position of the lesion, it achieves self-locking and positioning by relying on the friction between the silicone anti-slip pad and the outer wall of the outer sleeve 21. No manual support or additional clips are required, reducing the difficulty of assembly. All plugs 43 have small annular pull rings integrally injection molded at their outer ends. The pull rings are 3mm in diameter, without sharp edges, and are suitable for the patient's hand grip. The plugs 43 can be quickly inserted and removed by hand without the need for tweezers, cotton swabs, or other auxiliary tools. A single person can complete the opening and closing of the drug release channel. The silicone anti-slip pad and the pull rings of the plugs 43 are made of food-grade medical silicone material, which is odorless, does not irritate the oral mucosa, and can be sterilized at high temperatures and reused repeatedly.

[0024] In use, the first step of assembly is positioning and opening the hole. After sliding the plastic shell 41 to the corresponding area of ​​the lesion, release your hand. The silicone anti-slip pad will immediately lock the plastic shell 41 in place, preventing slippage. Simply hook your finger on the outer pull ring of the plug 43 and pull it outward to quickly remove the plug 43 from the lesion area. All other through holes 42 are sealed with plugs 43. The subsequent layered connection, initial drug injection into the drug storage chamber, installation of the drug delivery component 6, oral insertion, drug replenishment during use, and disassembly and cleaning after use are all consistent with the steps and sequence of Example 1. Only the positioning and opening step is more labor-saving and convenient, making it suitable for patients with limited mobility or weak hand strength who are undergoing radiotherapy and chemotherapy to independently complete the device assembly, greatly reducing the workload of medical staff in assisting the operation.

[0025] Example 3: The technical solution in this example, which differs from Example 2, includes the following upgrades: Based on the optimized structure of Example 2, the structure of the drug dispensing component 6 is further upgraded. Uniform transparent graduation lines are printed vertically along the side wall of the medicine box 61, with the graduation unit being ml, a minimum of 5ml, and a maximum of 30ml. The graduation lines are highly transparent, allowing for direct observation of the remaining medication volume inside the medicine box 61. This facilitates precise control of the single dispensing volume by medical personnel, preventing excessive overflow or frequent refills due to insufficient medication. A thin medical waterproof and breathable membrane is bonded inside the central vent 66 of the rubber sealing plate 65. This membrane allows only air circulation to balance the internal and external air pressure, completely preventing backflow of oral saliva, moisture, and microorganisms into the medicine box 61, thus contaminating the stored medication and extending its shelf life. The medicine box 61 is made entirely of transparent medical PC material. Combined with the graduation lines, it allows for simultaneous observation of medication turbidity, sedimentation, and deterioration, enabling timely replacement of the medication and improving medication safety.

[0026] In use, the initial positioning and opening, layering, and initial drug injection process of the drug storage chamber are exactly the same as in Example 2. When adding the reserve drug solution by assembling the drug delivery component 6, the volume is precisely controlled through the transparent drug box 61 and the scale lines. During the drug administration process, saliva and moisture inside the mouth cannot seep into the drug box 61 through the pores and contaminate the drug solution, resulting in a higher purity of the stored drug solution. When the drug solution in the storage chamber is consumed during use, the drug solution in the drug box 61 will not be diluted or deteriorated by moisture when the adjustment component 7 is used to replenish the drug. This can significantly extend the duration of continuous drug administration per session, reduce the frequency of patients removing the device to change the drug solution, and alleviate the discomfort caused by oral pain and difficulty opening the mouth in patients undergoing radiotherapy and chemotherapy. The convenience of clinical use and the safety of drug administration are significantly improved.

[0027] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of protection claimed by the present invention. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A targeted, adhesive, and controllable drug delivery aid device for oral mucosal inflammation treated with radiotherapy and chemotherapy, characterized in that: The device includes an inner rubber sleeve (1), on the surface of which a drug storage component (2) for storing liquid medicine is provided. A connecting pipe (3) is fixedly connected to the outer wall of the drug storage component (2). A positioning component (4) for positioning the drug application position is movably sleeved on the surface of the drug storage component (2). A drug application component (5) for releasing liquid medicine is movably sleeved on the surface of the positioning component (4). The other end of the connecting pipe (3) is snapped with a drug addition component (6) for adding liquid medicine to the drug storage component (2). An adjustment component (7) for controlling the flow of liquid medicine is provided inside the drug addition component (6). The drug storage component (2) includes an outer rubber sleeve (21), which is fixedly fitted onto the surface of the inner rubber sleeve (1), and a plurality of slots (22) are provided on the surface of the outer rubber sleeve (21). The positioning component (4) includes a plastic shell (41), which is slidably sleeved on the surface of the outer sleeve (21). Multiple through holes (42) are arrayed on the surface of the plastic shell (41), and a plug (43) is engaged inside the through hole (42). The drug delivery component (5) includes a coating gel (51), which is fitted onto the surface of a plastic shell (41), and the surface of the coating gel (51) has a plurality of fine pores (52).

2. The targeted, adhesive, controllable drug delivery aid device for oral mucositis treated with radiotherapy and chemotherapy according to claim 1, characterized in that: The plurality of the strip-shaped openings (22) correspond to the plurality of through holes (42), and the plurality of through holes (42) correspond to the plurality of fine holes (52).

3. The targeted, adhesive, controllable drug delivery aid device for oral mucositis treated with radiotherapy and chemotherapy according to claim 1, characterized in that: The surfaces of the outer rubber sleeve (21) and the inner rubber sleeve (1) are both elliptical, and a gap is provided between the outer rubber sleeve (21) and the inner rubber sleeve (1).

4. The targeted, adhesive, controllable drug delivery aid device for oral mucositis treated with radiotherapy and chemotherapy according to claim 1, characterized in that: The dosing assembly (6) includes a medicine box (61), a rubber tube (62) is fixedly connected to the lower side wall of the medicine box (61), the rubber tube (62) is snapped into the inside of the connecting tube (3), a blocking plate (63) is fixedly connected to the inner wall of the rubber tube (62), a round hole (64) is opened on the surface of the blocking plate (63), a rubber sealing plate (65) is snapped into the upper end of the medicine box (61), and an air hole (66) is opened at the center of the rubber sealing plate (65).

5. The targeted, adhesive, controllable drug delivery aid device for oral mucositis treated with radiotherapy and chemotherapy according to claim 4, characterized in that: The adjustment component (7) includes a rotating shaft (71), which is rotatably connected to the surface of the medicine box (61). One end of the rotating shaft (71) is fixedly connected to a rotating block (72), which is in contact with the blocking plate (63). The rotating block (72) has a groove (73) corresponding to the round hole (64) on its surface. A fixing sleeve (74) is fixedly fitted onto the surface of the rotating shaft (71). A rotating strip (75) is fixedly connected to one end of the rotating shaft (71) outside the medicine box (61). Two fixing strips (76) are fixedly connected to the surface of the medicine box (61). The fixing strips (76) are arranged at right angles around the rotating shaft (71).

6. The targeted, adhesive, controllable drug delivery aid device for oral mucositis treated with radiotherapy and chemotherapy according to claim 5, characterized in that: One end of the fixing sleeve (74) is attached to the rotating block (72), and the other end of the fixing sleeve (74) is attached to the inner wall of the medicine box (61).

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