Shampoo with anti-itching effect containing greenish-green mold and preparation method thereof

Abstract

The application discloses a bath foam with antipruritic effect containing green phenol and a preparation method thereof. The bath foam adopts a formula structure with water as a continuous phase, is composed of a surfactant, a thickening agent, a preservative, a pH regulator and green phenol, and the mass percentage of the green phenol is 0.01%-1%. Through a preparation process of controlling temperature and speed in stages, the components are fully dispersed in the system and a stable structure is formed, and finally, the bath foam product in a viscous liquid dosage form is obtained. The bath foam prepared by the application can effectively reduce the stimulation to the skin while ensuring good cleaning performance, and the patch test verifies that the bath foam has good soothing and antipruritic effect. Meanwhile, the product has small pH change, uniform appearance, is not easy to separate or separate water under high-temperature and low-temperature storage conditions, and has good system stability. The bath foam prepared by the application is suitable for frequent bathing and sensitive skin groups, and has good application prospect.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, and in particular to a shower gel containing chlorophenol kojic acid and having an antipruritic effect, and its preparation method. Background Technology

[0002] Shower gel is a type of daily chemical product used for cleansing human skin. It primarily removes sweat, sebum, and dirt from the skin's surface through a surfactant system, thus maintaining skin cleanliness and hygiene. With improved living standards and increased awareness of personal hygiene, bathing frequency has significantly increased, with some people even bathing once or more daily, greatly increasing the contact frequency between shower gel and skin. Human skin has numerous pores, sweat glands, and sebaceous glands, which normally secrete sebum and sweat to form a natural protective barrier. However, under the influence of frequent cleansing, chemical irritants, temperature changes, and mechanical friction, the skin barrier is easily damaged, inducing inflammatory reactions and leading to discomfort such as dryness, tightness, redness, and itching. These problems are particularly pronounced in people with sensitive skin.

[0003] Phosphoric acid koji is a bioactive functional ingredient. Studies have shown that it can regulate the expression of skin inflammation-related factors to some extent, alleviating skin discomfort caused by external stimuli and demonstrating good application potential in soothing the skin and reducing itching. However, phosphoric acid koji is rarely incorporated as a functional ingredient into cleansing formulations in existing shower gels, and its application methods and stable implementation in daily bath products still require further exploration. Summary of the Invention

[0004] To address the aforementioned problems, this invention proposes a shower gel containing chlorophyll kojic acid with antipruritic effects and its preparation method. This invention solves the problem that existing shower gels easily irritate the skin and cause discomfort such as itching during frequent cleansing, and lack effective soothing and antipruritic functional ingredients.

[0005] This invention can be achieved through the following technical solutions: A method for preparing a shower gel containing chlorophenol koji with antipruritic effects includes the following steps: Step 1: Add water to the emulsification pot, and add surfactant and thickener in sequence while stirring at 300-600 rpm. Heat the resulting mixture and control the temperature at 75-80℃, and continue stirring for 20-40 minutes to fully disperse the surfactant and thickener and form a homogeneous basic system. Step 2: Cool the base system to 40-45℃, then add the preservative and pH adjuster in sequence, and continue stirring for 10-20 minutes. Then add chlorophenol koji and continue stirring at 200-400 rpm for 5-15 minutes until the chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects.

[0006] Preferably, the mass percentage of water, surfactant, and thickener in step 1 is (50-80)%:(15-20)%:(1-6)%.

[0007] Preferably, the surfactant is one or more of sodium lauryl ether sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, potassium cocoyl glycinate, sodium lauroyl sarcosinate, and decyl glucoside.

[0008] Preferably, the thickener is one or more of PEG-150 distearate, cocamide MEA, and PEG-120 methyl glucoside.

[0009] Preferably, the uniform basic system in step 1 is in a uniform and transparent state.

[0010] Preferably, in step 2, the mass percentages of preservative, pH adjuster, and chlorophenol koji are (0.1-1)%:(0.1-0.4)%:(0.1-1)%.

[0011] Preferably, the preservative is one or more of 1,2-hexanediol, 1,2-pentanediol, p-hydroxyacetophenone, phenoxyethanol, and ethylhexylglycerin.

[0012] Preferably, the pH adjuster is one or more of citric acid, sodium citrate, and sodium hydroxide.

[0013] Preferably, the shower gel is a viscous liquid formulation.

[0014] The beneficial effects of this invention are: This invention, by rationally introducing chlorophenol koji into the shower gel formulation system, effectively reduces the product's skin irritation while ensuring its basic cleansing performance. Chlorphenol koji, as a bioactive functional ingredient, can form a relatively mild interface on the skin surface. Its molecular structure helps reduce the direct irritation of the skin barrier by surfactants, thereby minimizing interference with the skin's microenvironment during cleansing. Simultaneously, chlorophenol koji can, to some extent, regulate the release level of skin surface irritation-related factors, weakening the transmission intensity of external stimulus signals to nerve endings, thus alleviating itching.

[0015] Patch testing verified that the shower gel prepared according to this invention did not induce significant adverse skin reactions in multiple time-point tests, demonstrating good skin tolerance and stable soothing and antipruritic effects. It can significantly improve the problem of skin itching and discomfort easily caused by frequent use of existing shower gels. Furthermore, tests on pH value, appearance, and system stability show that the shower gel of this invention maintains a stable weakly acidic environment and uniform appearance under both high and low temperature storage conditions. The system is not prone to stratification, water separation, or significant viscosity changes, indicating good environmental adaptability and storage stability. In summary, this invention not only effectively balances cleansing, gentleness, and antipruritic functions, but also improves the long-term stability and safety of the product through synergistic design of the formulation and process, possessing high practical application value. Attached Figure Description

[0016] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings: Figure 1 These are the results of the pH stability test. Detailed Implementation

[0017] The following provides a detailed description of the embodiments of the present invention: These embodiments are implemented based on the technical solution of the present invention, and provide detailed implementation methods and processes. However, the scope of protection of the present invention is not limited to the following embodiments. Experimental methods in the following embodiments that do not specify specific conditions are generally performed under conventional conditions.

[0018] Example 1 A method for preparing a shower gel containing chlorophenol koji with antipruritic effects includes the following steps: Step 1: Add 78.9% water to the emulsifying pot, and add 18% sodium lauryl ether sulfate, cocamidopropyl betaine, sodium lauroyl amphoteric acetate, 2% PEG-150 distearate, and cocamidopropyl MEA in sequence while stirring at 400 rpm. Heat the resulting mixture and control the temperature at 80°C, and continue stirring for 20 minutes to form a homogeneous and transparent basic system. Step 2: Cool the base system to 45°C, then add 0.5% 1,2-hexanediol, p-hydroxyacetophenone, 0.1% citric acid, and sodium citrate in sequence, and continue stirring for 10-20 minutes. Then add 0.5% chlorophenol koji and continue stirring at 200 rpm for 15 minutes until chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects. This shower gel is a viscous liquid formulation.

[0019] Example 2 A method for preparing a shower gel containing chlorophenol koji with antipruritic effects includes the following steps: Step 1: Add 80% water to the emulsifying pot, and add 20% potassium cocoyl glycinate, sodium lauroyl sarcosinate, decyl glucoside and 6% PEG-120 methyl glucodioleate in sequence while stirring at 600 rpm. Heat the resulting mixture and control the temperature at 80°C. Continue stirring for 20 minutes to fully disperse the surfactant and thickener and form a uniform and transparent basic system. Step 2: Cool the base system to 45°C, then add 1% 1,2-pentanediol, phenoxyethanol and 0.4% sodium hydroxide in sequence, continue stirring for 20 minutes, then add 1% chlorophenol koji, and continue stirring at 400 rpm for 5 minutes until chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects. This shower gel is a viscous liquid formulation.

[0020] Example 3 A method for preparing a shower gel containing chlorophenol koji with antipruritic effects includes the following steps: Step 1: Add 65% water to the emulsification pot, and add 17.5% sodium lauryl ether sulfate and 3.5% PEG-150 distearate in sequence while stirring at 450 rpm. Heat the resulting mixture and control the temperature at 75°C. Continue stirring for 30 minutes to fully disperse the surfactant and thickener and form a uniform and transparent basic system. Step 2: Cool the base system to 40°C, then add 0.55% ethylhexylglycerin and 0.25% citric acid in sequence, continue stirring for 15 minutes, then add 0.55% chlorophenol koji, and continue stirring at 300 rpm for 10 minutes until the chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects. This shower gel is a viscous liquid formulation.

[0021] Example 4 A method for preparing a shower gel containing chlorophenol koji with antipruritic effects includes the following steps: Step 1: Add 50% water to the emulsification pot, and add 15% sodium lauroyl sarcosinate and 1% cocoamide MEA in sequence while stirring at 300 rpm. Heat the resulting mixture and control the temperature at 75°C. Continue stirring for 40 minutes to fully disperse the surfactant and thickener and form a uniform and transparent basic system. Step 2: Cool the base system to 40°C, then add 0.1% p-hydroxyacetophenone and 0.1% sodium citrate in sequence, continue stirring for 10 minutes, then add 0.1% chlorophenol koji, and continue stirring at 200 rpm for 15 minutes until chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects. This shower gel is a viscous liquid formulation.

[0022] Comparative Example 1: The difference between this comparative example and Example 1 is that no chlorophenol koji is added.

[0023] A method for preparing a shower gel with antipruritic effects includes the following steps: Step 1: Add 78.9% water to the emulsifying pot, and add 18% sodium lauryl ether sulfate, cocamidopropyl betaine, sodium lauroyl amphoteric acetate, 2% PEG-150 distearate, and cocamidopropyl MEA in sequence while stirring at 400 rpm. Heat the resulting mixture and control the temperature at 80°C, and continue stirring for 20 minutes to form a homogeneous and transparent basic system. Step 2: Cool the base system to 45℃, then add 0.5% 1,2-hexanediol, p-hydroxyacetophenone, 0.1% citric acid, and sodium citrate in sequence, and continue stirring for 10-20 minutes to obtain a shower gel with antipruritic effects. This shower gel is a viscous liquid formulation.

[0024] Comparative Example 2: The difference between this comparative example and Example 1 is that the amount of chlorophenol koji added is 0.1%.

[0025] A method for preparing a shower gel containing chlorophenol koji with antipruritic effects includes the following steps: Step 1: Add 78.9% water to the emulsifying pot, and add 18% sodium lauryl ether sulfate, cocamidopropyl betaine, sodium lauroyl amphoteric acetate, 2% PEG-150 distearate, and cocamidopropyl MEA in sequence while stirring at 400 rpm. Heat the resulting mixture and control the temperature at 80°C, and continue stirring for 20 minutes to form a homogeneous and transparent basic system. Step 2: Cool the base system to 45°C, then add 0.5% 1,2-hexanediol, p-hydroxyacetophenone, 0.1% citric acid, and sodium citrate in sequence, and continue stirring for 10-20 minutes. Then add 0.1% chlorophenol koji and continue stirring at 200 rpm for 15 minutes until chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects. This shower gel is a viscous liquid formulation.

[0026] Performance testing 1. Patch test for skin irritation and itch relief Thirty healthy volunteers who meet the trial requirements will be recruited. One week prior to the trial, volunteers will cease using any functional skincare or cleansing products on the test area. A sample of the shower gel prepared according to this invention will be added to a standard closed patch applicator at a dosage of 0.02 mL–0.025 mL. The patch will be applied to the flexor surface of the subject's forearm and held for 24 hours. After 24 hours, the patch will be removed, and observations and records will be made at 0.5 h, 24 h, and 48 h after removal. Skin reactions at each time point will be recorded, along with the skin reaction grade and the corresponding number of participants.

[0027] Table 1. Results of patch tests related to skin irritation and itch relief

[0028] Table 1 shows that in Examples 1-3, skin reactions at 0.5h, 24h, and 48h were predominantly grade 0, with no moderate or severe irritation reactions observed. This indicates that the shower gel prepared in this invention has excellent skin tolerance and significant soothing and antipruritic effects. In contrast, Comparative Example 1, without chlorophenol koji, showed a higher proportion of grade 1 and 2 skin reactions at 0.5h and 24h, indicating that shower gels relying solely on basic cleansing systems still have some irritant properties when frequently in contact with the skin. Comparative Example 2 added 0.1% chlorophenol koji; however, due to the small proportion of chlorophenol koji used, the soothing effect was minimal, and the number of people experiencing skin reactions was still lower than the overall level of the Examples 1-3. These results demonstrate that chlorophenol koji, when added in a reasonable amount, can effectively reduce the skin's reaction to external stimuli and continuously exert a soothing and antipruritic effect during bathing, thereby significantly improving the product's skin safety.

[0029] 2 pH stability test The pH stability of the shower gel was tested according to GB / T 13531.1-2008 standard.

[0030] Table 2 pH stability test results

[0031] Table 2 shows that the initial pH of Examples 1-4 was controlled between 5.7 and 6.0, meeting the weakly acidic requirements of mild cleansing shower gels. After storage at 45℃ for 7 days and -5℃ for 48 hours, the pH change range of the sample samples was 0.2, demonstrating excellent pH stability. In contrast, the pH change of Comparative Example 1 (without chlorophenol koji) was 0.5, and the pH change of Comparative Example 2 (with too low chlorophenol koji content) was 0.6, both greater than those of the Examples, indicating that the appropriate addition of chlorophenol koji helps maintain the acid-base balance and stability of the system.

[0032] 3. Appearance and System Stability Testing Take the shower gel samples prepared according to this invention and place them in transparent sealed containers. Observe their initial appearance, including color, transparency, and uniformity, at room temperature. Then, place the samples in a high-temperature environment (45±2℃) and a low-temperature environment (-5±2℃) for a specified time, and then return them to room temperature to observe whether the samples show stratification, precipitation, water separation, or significant viscosity changes. At the same time, gently shake the samples and let them stand, recording their appearance recovery and overall uniformity changes.

[0033] Table 3. Results of Appearance and System Stability Tests

[0034] Table 3 shows that Examples 1-3 did not exhibit stratification, water separation, or significant precipitation under both 45℃ and −5℃ high-temperature and low-temperature conditions. The samples maintained a uniform and stable appearance after returning to room temperature, indicating a complete system structure and good stability. In contrast, Comparative Example 1 showed stratification at high temperatures and significant turbidity at low temperatures, with a slow recovery process; Comparative Example 2 also exhibited localized stratification and slight water separation, indicating significantly insufficient system stability. These results demonstrate that the components in the shower gel formulation of this invention have good compatibility. The stable dispersion of chlorophenol koji in the system helps maintain the continuous phase structure constructed by the surfactant and thickener, thereby significantly improving the appearance and system stability of the product under different environmental conditions.

[0035] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A method for preparing a shower gel containing chlorophenol koji with antipruritic effects, characterized in that, Includes the following steps: Step 1: Add water to the emulsification pot, and add surfactant and thickener in sequence while stirring at 300-600 rpm. Heat the resulting mixture and control the temperature at 75-80℃, and continue stirring for 20-40 minutes to fully disperse the surfactant and thickener and form a homogeneous basic system. Step 2: Cool the base system to 40-45℃, then add the preservative and pH adjuster in sequence, and continue stirring for 10-20 minutes. Then add chlorophenol koji and continue stirring at 200-400 rpm for 5-15 minutes until the chlorophenol koji is evenly dispersed in the system. Continue cooling to room temperature to obtain a shower gel containing chlorophenol koji with antipruritic effects.

2. The method for preparing the shower gel containing chlorophyll and having antipruritic effects according to claim 1, characterized in that, In step 1, the mass percentages of water, surfactant, and thickener are (50-80)%: (15-20)%: (1-6)%.

3. The method for preparing the shower gel containing chlorophyll koji with antipruritic effect according to claim 2, characterized in that, The surfactant is one or more of sodium lauryl ether sulfate, cocamidopropyl betaine, sodium lauroamphoacetate, potassium cocoyl glycinate, sodium lauroyl sarcosinate, and decyl glucoside.

4. The method for preparing the shower gel containing chlorophyll and having antipruritic effects according to claim 2, characterized in that, The thickener is one or more of PEG-150 distearate, cocoamide MEA, and PEG-120 methyl glucoside dioleate.

5. The method for preparing the shower gel containing chlorophyll and having antipruritic effects according to claim 1, characterized in that, The uniform basic system in step 1 is in a uniform and transparent state.

6. The method for preparing the shower gel containing chlorophyll koji with antipruritic effect according to claim 1, characterized in that, In step 2, the mass percentages of preservative, pH adjuster, and chlorophenol koji are (0.1-1)%:(0.1-0.4)%:(0.1-1)%.

7. The method for preparing the shower gel containing chlorophyll and having antipruritic effects according to claim 6, characterized in that, The preservative is one or more of 1,2-hexanediol, 1,2-pentanediol, p-hydroxyacetophenone, phenoxyethanol, and ethylhexylglycerin.

8. The method for preparing a shower gel containing chlorophenol koji with antipruritic effects according to claim 6, characterized in that, The pH adjuster is one or more of citric acid, sodium citrate, and sodium hydroxide.

9. The method for preparing the shower gel containing chlorophyll and having antipruritic effects according to claim 1, characterized in that, The shower gel is a viscous liquid formulation.

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