A multi-channel magnetic field detection device

Abstract

The application provides a multi-channel magnetic field detection device applied to a cell culture plate including a plurality of culture dishes and including a detection plate and a control circuit; the detection plate includes a plurality of magnetic field detection parts; the plurality of magnetic field detection parts correspond to the plurality of culture dishes one by one and correspond in position; each magnetic field detection part is used for detecting the magnetic field distribution of the culture dish corresponding to the magnetic field detection part; the control circuit is electrically connected with the plurality of magnetic field detection parts; and the control circuit is used for controlling the plurality of magnetic field detection parts so that at most one magnetic field detection part in the plurality of magnetic field detection parts is in a working state in the same time period. In the embodiment of the application, the operation process of manually switching the relative position between the magnetic field detection device and the cell culture plate to perform magnetic field detection in the same test process can be omitted, the operation process is simplified, and the time cost in the test process is saved.

Description

Technical Field

[0001] This application relates to the field of magnetic field therapy technology, specifically to a multi-channel magnetic field detection device. Background Technology

[0002] Alternating magnetic field therapy devices are widely used in cellular-level physical therapy research, such as promoting cell proliferation and inhibiting tumor growth. To verify the therapeutic effect of alternating magnetic field therapy devices on cells in cell culture dishes, it is necessary to accurately measure the magnetic field strength and distribution in each well of the cell culture plate.

[0003] Currently, most treatments use single-point probes as magnetic field detection devices to perform point-by-point magnetic field detection on cultured tissues within cell culture dishes. This method suffers from technical problems such as low measurement efficiency, poor positional repeatability, and the inability to simultaneously acquire triaxial components including the X, Y, and Z axes. Furthermore, when multiple cultured tissues need to be detected simultaneously, the single-point probe must be switched between different cultured tissues for synchronous detection, which is cumbersome. Therefore, there is an urgent need for a magnetic field distribution measurement device specifically designed for cell culture plates that supports multi-point triaxial synchronous detection. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention discloses a multi-channel magnetic field detection device. This device improves upon existing technologies that primarily use single-point probes to detect magnetic fields point-by-point within cultured tissues in cell culture dishes. This method suffers from several technical issues, including low measurement efficiency, poor position repeatability, and the inability to simultaneously acquire triaxial components including the X, Y, and Z axes. Furthermore, when multiple cultured tissues need to be detected simultaneously, the single-point probe must be switched between different cultured tissues for simultaneous detection, resulting in cumbersome operation.

[0005] To achieve the above objectives, this application provides a multi-channel magnetic field detection device, which is applied to a cell culture plate including several culture dishes and includes a detection plate and a control circuit. The detection plate includes several magnetic field detection units; each of the several magnetic field detection units corresponds to one of the several culture dishes, and their positions are corresponding. Each magnetic field detection unit is used to detect the magnetic field distribution of the culture dish corresponding to each magnetic field detection unit; The control circuit is electrically connected to the plurality of magnetic field detection units; the control circuit is used to control the plurality of magnetic field detection units so that at most one magnetic field detection unit is in working state at the same time.

[0006] In one possible embodiment, each magnetic field detection unit is provided with a plurality of triaxial Hall sensors evenly distributed within it. The plurality of triaxial Hall sensors are used to detect the triaxial magnetic field components of the culture dish corresponding to each magnetic field detection unit.

[0007] In one possible embodiment, five triaxial Hall sensors are uniformly distributed within each magnetic field detection unit. The five triaxial Hall sensors are used to detect the spatial magnetic field components along the X, Y, and Z axes of the culture dish corresponding to each magnetic field detection unit.

[0008] In one possible embodiment, each magnetic field detection unit includes a multiplexer; a plurality of triaxial Hall sensors within each magnetic field detection unit are connected to a control circuit via the multiplexer.

[0009] In one possible embodiment, the control circuitry includes an SPI bus; the SPI bus is used to transmit a chip select signal. The enable terminal of the multiplexer in each magnetic field detection unit is connected to the SPI bus via an OR gate.

[0010] In one possible embodiment, the control circuit includes a main control board; The main control board and the detection board are electrically connected to two sets of address lines via the SPI bus.

[0011] In one possible embodiment, the two sets of address lines include 4-bit address lines and 3-bit address lines; the two sets of address lines are used to sequentially select the triaxial Hall sensors in the plurality of magnetic field detection units.

[0012] In one possible embodiment, the multi-channel magnetic field detection device further includes a power supply module; The power supply module includes a charging interface; the detection board and / or the control circuit can complete the charging function through the charging interface.

[0013] In one possible embodiment, the control circuit is used to control the plurality of magnetic field detection units so that the plurality of magnetic field detection units perform detection in at least two detection modes; The control circuit is also used to control several magnetic field detection units so that the several magnetic field detection units can collect data in at least two acquisition modes.

[0014] In one possible embodiment, the at least two detection channels include an X-channel detection mode, a Y-channel detection mode, a Z-channel detection mode, a SUM detection mode, and an AVG detection mode; The acquisition modes include a real-time display mode and a peak mode; when the multi-channel magnetic field detection device performs magnetic field detection in the peak mode, the multi-channel magnetic field detection device is used to detect the dynamic peak value of the culture dish corresponding to each magnetic field detection unit during the first working period.

[0015] The technical solution provided in this application has the following technical effects: In the embodiments of this application, the operation experiment can be carried out by detecting the magnetic field of the culture dish through several magnetic field detection units. Since the several magnetic field detection units correspond one-to-one with several culture dishes and their positions are corresponding, the detection plate can be aligned with each magnetic field detection unit and its corresponding culture dish by means including but not limited to manual alignment or covering. This eliminates the need to manually switch the relative position between the magnetic field detection device and the cell culture plate to perform magnetic field detection in the same test process, which simplifies the operation process and saves time costs in the test process. Attached Figure Description

[0016] To more clearly illustrate the technical solutions and advantages in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the structure of the detection plate of a multi-channel magnetic field detection device provided in an embodiment of this application. Figure 1 ; Figure 2 This is a schematic diagram of the main control board of a multi-channel magnetic field detection device provided in an embodiment of this application. Figure 2 ; Figure 3 This is a schematic diagram of the human-computer interaction interface of a multi-channel magnetic field detection device provided in this application embodiment when switching between detection mode and acquisition mode; Figure 4 This is a schematic diagram showing the human-computer interaction interface of a multi-channel magnetic field detection device provided in this application during the detection process; The labels in the diagram are explained as follows: 1-Detection board; 11-Magnetic field detection unit; 111-Triaxial Hall sensor; 2-Main control board; 3-Power supply module. Detailed Implementation

[0018] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0019] It should be noted that the term "an embodiment" or "embodiment" in the specification of the embodiments of this application refers to a specific feature, structure, or characteristic that can be included in at least one implementation of this application. It should be understood that in the specification, claims, and accompanying drawings of the embodiments of this application, the terms "upper," "lower," "top," "bottom," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application. The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined with "first" and "second" may explicitly or implicitly include one or more of that feature. Moreover, the terms "first," "second," etc., are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence.

[0020] Please see Figures 1 to 4 This application provides a multi-channel magnetic field detection device, which is applied to a cell culture plate including several culture dishes, and includes a detection plate 1 and a control circuit. The detection plate 1 can be a detection device for detecting cell culture dishes, and the control circuit can be used to control the detection plate 1 and transmit data.

[0021] In one possible embodiment, the detection plate 1 includes a plurality of magnetic field detection units 11, each capable of detecting the magnetic field of the culture dish. The plurality of magnetic field detection units 11 correspond one-to-one with the plurality of culture dishes, and their positions are corresponding.

[0022] Since several magnetic field detection units 11 correspond one-to-one with several culture dishes and are positioned accordingly, the detection plate 1 can be aligned with each magnetic field detection unit 11 and its corresponding culture dish by means including but not limited to manual alignment or covering. This eliminates the need to manually switch the relative positions between the magnetic field detection device and the cell culture plate to perform magnetic field detection during the same test process.

[0023] Optionally, each magnetic field detection unit 11 is used to detect the magnetic field distribution of the culture dish corresponding to each magnetic field detection unit 11. During the detection process of the multi-channel magnetic field detection device, the detection process of several magnetic field detection units 11 can be performed individually. At any given time, only one of the several magnetic field detection units 11 on the detection plate 1 is working.

[0024] Optionally, the control circuit can be electrically connected to the plurality of magnetic field detection units 11, and the control circuit can control the plurality of magnetic field detection units 11. The control circuit is used to control the plurality of magnetic field detection units 11 so that at most one magnetic field detection unit 11 is in working state at the same time, thereby preventing mutual interference between different magnetic field detection units 11.

[0025] Therefore, in the embodiments of this application, the operation experiment can be carried out by detecting the magnetic field of the culture dish through a plurality of magnetic field detection units 11. Since the plurality of magnetic field detection units 11 correspond one-to-one with the plurality of culture dishes and are in corresponding positions, the detection plate 1 can be aligned with each magnetic field detection unit 11 and the corresponding culture dish by means including but not limited to manual alignment or covering. This eliminates the need to manually switch the relative position between the magnetic field detection device and the cell culture plate to perform magnetic field detection in the same test process, which simplifies the operation process and saves time costs in the test process.

[0026] In one possible embodiment, each magnetic field detection unit 11 is provided with a plurality of triaxial Hall sensors 111 evenly distributed within it. When each magnetic field detection unit 11 performs magnetic field detection on the cultured tissue in the culture dish, the plurality of triaxial Hall sensors 111 are also evenly distributed within the culture dish, thereby enabling multi-point dispersed detection of the cultured tissue in the culture dish, so that the average value of the multi-point dispersed detection can be taken to improve the accuracy of the detection.

[0027] Optionally, the plurality of triaxial Hall sensors 111 are used to detect the triaxial magnetic field components of the culture dish corresponding to each magnetic field detection unit 11.

[0028] Optionally, the control circuit is used to control the plurality of magnetic field detection units 11 so that at most one triaxial Hall sensor 111 is in working state among the plurality of magnetic field detection units 11 at the same time, so as to prevent different triaxial Hall sensors 111 from interfering with each other.

[0029] In one possible embodiment, each magnetic field detection unit 11 is provided with five triaxial Hall sensors 111 evenly distributed within it. When the magnetic field detection unit 11 is used to detect the magnetic field of the cultured tissue, these five triaxial Hall sensors 111 can be evenly distributed within the culture dish, thereby enabling multi-point dispersed detection of the cultured tissue in the culture dish.

[0030] Optionally, the five triaxial Hall sensors 111 are used to detect the spatial magnetic field components along the X, Y, and Z axes of the culture dish corresponding to each magnetic field detection unit 11, thereby achieving synchronous detection of the spatial magnetic field components of multiple defense lines.

[0031] In one possible embodiment, each magnetic field detection unit 11 includes a multiplexer. A plurality of triaxial Hall sensors 111 within each magnetic field detection unit 11 are connected to a control circuit via the multiplexer.

[0032] The control circuit can use a multiplexer to select multiple sensors in a time-division multiplexing manner with fewer control lines, thereby significantly reducing the pin resources occupied by the control circuit.

[0033] In one possible embodiment, the control circuit includes an SPI bus. The SPI bus is used to send chip select signals to achieve signal transmission with each of the magnetic field detection units 11.

[0034] Optionally, the enable terminal of the multiplexer of each magnetic field detection unit 11 is connected to the SPI bus via an OR gate, and the control circuit can ensure that at any given time, at most one magnetic field detection unit 11 is in working state among the several magnetic field detection units 11 during the same period.

[0035] In one possible embodiment, the control circuit includes a main control board 2, which can be used as the main control unit of the control circuit.

[0036] Optionally, the main control board 2 and the detection board 1 are electrically connected to two sets of address lines via the SPI bus. The main control board 2 can be connected to the detection board 1 via DuPont wires to read the magnetic field data of the X-axis, Y-axis and Z-axis.

[0037] In one possible embodiment, the two sets of address lines include 4-bit address lines and 3-bit address lines. The two sets of address lines are used to sequentially select the triaxial Hall sensors 111 within the plurality of magnetic field detection units 11.

[0038] In one possible embodiment, the multi-channel magnetic field detection device further includes a power supply module 3. The power supply module 3 can be used to charge the main control board 2 and the detection board 1, among other things. The power supply module 3 can be integrated onto the main control board 2.

[0039] Optionally, the power supply module 3 includes a charging interface, which can be a USB interface or a Type-C interface. The detection board 1 and / or the control circuit can complete the charging function through the charging interface, thereby enabling the multi-channel magnetic field detection device to operate offline, improving the portability of the multi-channel magnetic field detection device, and allowing for flexible placement in devices / equipment including but not limited to cell culture rooms, clean benches, and electromagnetic shielding boxes.

[0040] In one possible embodiment, the control circuit is used to control the plurality of magnetic field detection units 11 so that the plurality of magnetic field detection units 11 perform magnetic field detection in at least two detection modes.

[0041] Optionally, the control circuit is also used to control a plurality of magnetic field detection units 11 so that the plurality of magnetic field detection units 11 collect data in at least two acquisition modes.

[0042] Optionally, the control circuit may include a human-machine interface, which may include interactive buttons for human interaction, allowing users to select and switch between detection and acquisition modes.

[0043] Optionally, the human-computer interaction interface can be used to display the remaining battery power and automatically alert when the battery is low.

[0044] In one possible embodiment, the at least two detection channels include an X-channel detection mode, a Y-channel detection mode, a Z-channel detection mode, a SUM detection mode, and an AVG detection mode.

[0045] The acquisition modes include a real-time display mode and a peak mode. When the multi-channel magnetic field detection device uses the real-time display mode for magnetic field detection, the human-machine interface displays the detection data of the detection plate 1 in real time. When the multi-channel magnetic field detection device uses the peak mode for magnetic field detection, the multi-channel magnetic field detection device is used to detect the dynamic peak value of the culture dish corresponding to each magnetic field detection unit 11 during the first working period, and the human-machine interface is used to display the dynamic peak value in real time. The first working period can be in the millisecond or second range, and the user can modulate the first working period according to the actual detection needs.

[0046] The following is the control program for a multi-channel magnetic field detection device detection board and control circuit provided in this application: / * Infinite loop * / / * USER CODE BEGIN WHILE * / while (1) { / * USER CODE END WHILE * / / * USER CODE BEGIN 3 * / HAL_UART_Receive_IT(&huart1, rx_buf,4); / / menu { if(confirm == 0){ if(show == 1 && select == 0){ TFTSPI_P8X8Str(0, 15, "CHN:",u16BLACK,u16GREEN); TFTSPI_P8X8Str(10, 15, "MODE:",u16WHITE,u16BLACK); } if(show == 1 && select == 1){ TFTSPI_P8X8Str(0, 15, "CHN:",u16WHITE,u16BLACK); TFTSPI_P8X8Str(10, 15, "MODE:",u16BLACK,u16GREEN); } if(show == 0){ TFTSPI_P8X8Str(0, 15, "CHN:",u16WHITE,u16BLACK); TFTSPI_P8X8Str(10, 15, "MODE:",u16WHITE,u16BLACK); } TFTSPI_P8X8Str(12, 14, " ",u16WHITE,u16BLACK); } if(confirm == 1){ if(select == 0){ TFTSPI_P8X8Str(0, 15, "CHN:",u16BLACK,u16GREEN); TFTSPI_P8X8Str(10, 15, "MODE:",u16WHITE,u16BLACK); } if(select == 1){ TFTSPI_P8X8Str(0, 15, "CHN:",u16WHITE,u16BLACK); TFTSPI_P8X8Str(10, 15, "MODE:",u16BLACK,u16GREEN); } TFTSPI_P8X8Str(12, 14, "LOCKED",u16WHITE,u16BLACK); } switch(chn){ case 0:TFTSPI_P8X8Str(5, 15, "CH X",u16WHITE,u16BLACK);break; case 1:TFTSPI_P8X8Str(5, 15, "CH Y",u16WHITE,u16BLACK);break; case 2:TFTSPI_P8X8Str(5, 15, "CH Z",u16WHITE,u16BLACK);break; case 3:TFTSPI_P8X8Str(5, 15, "3AVG",u16WHITE,u16BLACK);break; case 4:TFTSPI_P8X8Str(5, 15, "ALL ",u16WHITE,u16BLACK);break; } if(peek == 0)TFTSPI_P8X8Str(15, 15, "NOR ",u16WHITE,u16BLACK); if(peek == 1)TFTSPI_P8X8Str(15, 15, "PEEK",u16WHITE,u16BLACK); } / / menu / / calculating for(enadd = 0;enadd <= 11;enadd++){ for(add = 0;add <= 4;add++){ Address_Select(enadd,add); / / filter max_temp = 0; min_temp = 0; if(enadd == 0 && add == 0){ mag_print = ((float)getXresult() / 32768) * 25; / / mag_print = getXrange(); } mag_x_f = fabsf(getMeasurementNrmlX()); mag_y_f = fabsf(getMeasurementNrmlY()); mag_z_f = fabsf(getMeasurementNrmlZ()); InitTMAG5170(); / / channal select switch(chn){ case 0:mag_temp = mag_x_f;break; case 1:mag_temp = mag_y_f;break; case 2:mag_temp = mag_z_f;break; case 3:mag_temp = (mag_x_f + mag_y_f + mag_z_f) / 3;break; case 4:mag_temp = mag_x_f + mag_y_f + mag_z_f;break; } / / max and min if (mag_temp > max_temp){ max_temp = mag_temp; } if (mag_temp < min_temp){ min_temp = mag_temp; } mag_buf_last[enadd][add] = mag_buf[enadd][add]; mag_buf[enadd][add] = mag_temp; if(mag_buf[enadd][add] > mag_buf_last[enadd][add]){ mag_buf_max[enadd][add] = mag_buf[enadd][add];} else if(mag_buf[enadd][add] < mag_buf_last[enadd][add]){ mag_buf_max[enadd][add] = mag_buf_last[enadd][add];} if(peek == 1){ mag_buf[enadd][add] = mag_buf_max[enadd][add];} / / printf("part:%d,num:%d,vaule:%2.2f\r\n",enadd,add,mag_buf[enadd][add]); printf("part:%d,num:%d,vaule:%2.2f\r\n",enadd,add,mag_print); } result[enadd] = (float)(mag_buf[enadd][0]+mag_buf[enadd][1]+mag_buf[enadd][2]+mag_buf[enadd][3]+mag_buf[enadd][4]) / (float)5; / / printf("part:%d,vaule:%2.2f\r\n",enadd,result[enadd]) } printf("\r\n"); / / end calculate / / display TFT_Showdecimal(0,2,result[3],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(0,4,result[2],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(0,6,result[1],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(0,8,result[0],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(7,2,result[7],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(7,4,result[6],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(7,6,result[5],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(7,8,result[4],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(14,2,result

[11] ,2,2,u16WHITE,u16BLACK); TFT_Showdecimal(14,4,result

[10] ,2,2,u16WHITE,u16BLACK); TFT_Showdecimal(14,6,result[9],2,2,u16WHITE,u16BLACK); TFT_Showdecimal(14,8,result[8],2,2,u16WHITE,u16BLACK); / / TFT_Showdecimal(7,10,mag_print,2,2,u16WHITE,u16PURPLE); } / * USER CODE END 3 * / } It should be noted that the order of the embodiments described above is merely for descriptive purposes and does not represent the superiority or inferiority of the embodiments. Furthermore, specific embodiments have been described above. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps described in the claims can be performed in a different order than that shown in the embodiments and still achieve the desired result. Additionally, the processes depicted in the drawings do not necessarily require a specific or sequential order to achieve the desired result. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.

[0047] The various embodiments in this specification are described in a progressive manner. Similar or identical parts between embodiments can be referred to mutually. Each embodiment focuses on describing the differences from other embodiments. In particular, the device embodiments are basically similar to the method embodiments, so the description is relatively simple; relevant parts can be referred to the descriptions of the method embodiments.

Claims

1. A multi-channel magnetic field detection device, characterized in that, It is applied to cell culture plates comprising several culture dishes and includes a detection plate and control circuitry; The detection plate includes several magnetic field detection units; each of the several magnetic field detection units corresponds to one of the several culture dishes, and their positions are corresponding. Each magnetic field detection unit is used to detect the magnetic field distribution of the culture dish corresponding to each magnetic field detection unit; The control circuit is electrically connected to the plurality of magnetic field detection units; the control circuit is used to control the plurality of magnetic field detection units so that at most one magnetic field detection unit is in working state at the same time.

2. The multi-channel magnetic field detection device according to claim 1, characterized in that, Each magnetic field detection unit is equipped with several triaxial Hall sensors that are evenly distributed within it. The plurality of triaxial Hall sensors are used to detect the triaxial magnetic field components of the culture dish corresponding to each magnetic field detection unit.

3. The multi-channel magnetic field detection device according to claim 2, characterized in that, Each magnetic field detection unit is equipped with five triaxial Hall sensors that are evenly distributed within it. The five triaxial Hall sensors are used to detect the spatial magnetic field components along the X, Y, and Z axes of the culture dish corresponding to each magnetic field detection unit.

4. The multi-channel magnetic field detection device according to claim 2, characterized in that, Each magnetic field detection unit includes a multiplexer; several triaxial Hall sensors within each magnetic field detection unit are connected to the control circuit via the multiplexer.

5. The multi-channel magnetic field detection device according to claim 4, characterized in that, The control circuit includes an SPI bus; the SPI bus is used to send chip select signals. The enable terminal of the multiplexer in each magnetic field detection unit is connected to the SPI bus via an OR gate.

6. The multi-channel magnetic field detection device according to claim 1, characterized in that, The control circuit includes a main control board; The main control board and the detection board are electrically connected to two sets of address lines via the SPI bus.

7. The multi-channel magnetic field detection device according to claim 6, characterized in that, The two sets of address lines include 4-bit address lines and 3-bit address lines; the two sets of address lines are used to sequentially select the triaxial Hall sensors in the plurality of magnetic field detection units.

8. The multi-channel magnetic field detection device according to claim 1, characterized in that, It also includes a power supply module; The power supply module includes a charging interface; the detection board and / or the control circuit can complete the charging function through the charging interface.

9. The multi-channel magnetic field detection device according to claim 1, characterized in that, The control circuit is used to control the plurality of magnetic field detection units so that the plurality of magnetic field detection units perform detection in at least two detection modes; The control circuit is also used to control several magnetic field detection units so that the several magnetic field detection units can collect data in at least two acquisition modes.

10. The multi-channel magnetic field detection device according to claim 9, characterized in that, The at least two detection channels include X-channel detection mode, Y-channel detection mode, Z-channel detection mode, SUM detection mode, and AVG detection mode; The acquisition modes include a real-time display mode and a peak mode; when the multi-channel magnetic field detection device performs magnetic field detection in the peak mode, the multi-channel magnetic field detection device is used to detect the dynamic peak value of the culture dish corresponding to each magnetic field detection unit during the first working period.

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