A net penetration astringent wet compress solution and its preparation method and application

Abstract

This invention belongs to the field of cosmetic technology, specifically relating to a cleansing and astringent wet compress solution, its preparation method, and its application. By weight, the cleansing and astringent wet compress solution comprises the following ingredients: 5-20 parts of stir-fried Tribulus terrestris, 5-20 parts of Centella asiatica, 5-15 parts of Kochia scoparia, 5-10 parts of Paeonia suffruticosa, 1-5 parts of dried ginger, and 2-10 parts of Spirodela polyrhiza. By mixing the above ingredients according to specific weight proportions, each ingredient can work synergistically to not only gently cleanse skin of oil and dirt, soothe itching, redness, and sensitivity, but also effectively inhibit inflammation, improve acne and pimples, promote pigment metabolism, fade acne scars, and brighten skin tone. Through oil control, pore tightening, and barrier repair, it improves enlarged pores, leaving the skin delicate and clear. This product is green and safe, has a good skin feel, and excellent effects.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a cleansing and astringent wet compress liquid, its preparation method, and its application. Background Technology

[0002] Modern lifestyles are often disrupted by irregular sleep patterns, stress, environmental pollution, and hormonal fluctuations, leading to widespread issues such as enlarged pores, excessive sebum production, frequent blackheads and acne, and dull, rough skin, severely impacting people's lives and social interactions. Wet compresses, with their high hydration, enhanced penetration, and immediate soothing properties, have become a mainstream approach to addressing these problems.

[0003] However, existing wet compress products have the following defects: (1) Single efficacy. Due to the relatively simple main ingredients of wet compress liquid (such as witch hazel, alcohol, and aluminum salt), it can only achieve immediate pore shrinkage and cannot deeply dissolve oil, dead skin cells and blackheads in the pores, which can easily lead to repeated enlargement of pores. Some cleansing products can unclog pores, but they are highly irritating and can easily cause redness, stinging and barrier damage. They can also easily dry out the skin after oil control, which can disrupt the water-oil balance. (2) Insufficient gentleness. That is, the effect is significant in the short term, but long-term use may damage the skin barrier and induce problems such as sensitivity, acne and blackhead aggravation. (3) Poor skin feel and user experience. For example, high concentrations of active ingredients can easily lead to a sticky skin feel, slow absorption, and strong residue after wet compress, which affects subsequent skin care steps. That is, existing products lack the synergistic effects of cleansing, tightening, moisturizing and repairing, which are prone to rebound and have a poor skin feel. Therefore, if a wet compress product could be provided that combines cleansing and itch relief, acne removal and whitening, and pore shrinking, while also being green, safe, and having a pleasant skin feel, it would fully meet market demand. Summary of the Invention

[0004] The purpose of this invention is to provide a cleansing and astringent wet compress solution, its preparation method and application, which has the effects of cleansing and relieving itching, removing acne and whitening, shrinking pores, and is green, safe and has a good skin feel.

[0005] This invention provides a cleansing and astringent wet compress solution, comprising the following ingredients by weight: Stir-fried Tribulus terrestris 5-20 parts, Centella asiatica 5-20 parts, Kochia scoparia 5-15 parts, Paeonia suffruticosa 5-10 parts, dried ginger 1-5 parts, and duckweed 2-10 parts.

[0006] Preferably, the ingredients, by weight, include the following raw materials: 10 parts stir-fried Tribulus terrestris, 10 parts Centella asiatica, 10 parts Kochia scoparia, 5 parts Paeonia suffruticosa, 3 parts dried ginger, and 5 parts duckweed.

[0007] This invention provides a method for preparing the cleansing and astringent wet compress solution described in the above technical solution, comprising the following steps: S1 mixes and crushes Centella asiatica and duckweed to obtain a first crushed material; mixes the first crushed material with water for soaking, first decoction, and filtration to obtain filtrate and first residue; refrigerates the filtrate to obtain a first filtrate. S2 involves mixing the first filter residue, water, and a compound enzyme for enzymatic hydrolysis, enzyme inactivation, and filtration to obtain an enzymatic hydrolysate; the compound enzyme includes bromelain and cellulase. S3 mixes stir-fried Tribulus terrestris, Kochia scoparia, Paeonia suffruticosa and dried ginger, freezes and pulverizes them to obtain a second pulverized material; mixes the second pulverized material with water for a second decoction and filtration to obtain a second residue and a second filtrate; S4 mixes and soaks the second filter residue with glycerin, then extracts it by high-vacuum distillation to obtain the distillate; combine the first filtrate, enzymatic hydrolysate, distillate and second filtrate to obtain the cleansing and astringent wet compress solution.

[0008] Preferably, in step S1, the mass ratio of the first pulverized material to water is 1:20-30; the first decoction time is 30-40 minutes, and the temperature is 85-100℃.

[0009] Preferably, in step S2, the mass ratio of the first filter residue, water, and compound enzyme is 1:15-20:0.01-0.03; and the mass ratio of bromelain to cellulase in the compound enzyme is 1.8-2.3:1. The enzymatic hydrolysis is performed at a temperature of 45-52℃ for 30-45 minutes.

[0010] Preferably, in step S3, the mass ratio of the second pulverized material to water is 1:15-25; the second decoction time is 20-30 minutes, and the temperature is 85-100℃.

[0011] Preferably, in step S4, the second filter residue is mixed with glycerol at a mass ratio of 1:2-3 and soaked for 10-15 minutes at 25-30°C. The vacuum degree of the high-vacuum distillation extraction is 110-130 mPa, and the time is 1-1.5 h.

[0012] Preferably, in step S1, the refrigeration temperature is 5-10°C and the time is 3-5 hours; In step S3, the mixed raw materials are frozen at -10°C to -1°C for 1-2 hours.

[0013] This invention provides the application of the above-described cleansing and astringent wet compress solution in the preparation of skin care products.

[0014] Preferably, the skin care product has at least one of the following effects (1)-(3): (1) Cleanses and relieves itching; (2) Acne removal and skin whitening; (3) Shrink pores.

[0015] Beneficial effects: This invention provides a cleansing and astringent wet compress solution, comprising the following ingredients by weight: 5-20 parts of stir-fried Tribulus terrestris, 5-20 parts of Centella asiatica, 5-15 parts of Kochia scoparia, 5-10 parts of Paeonia suffruticosa, 1-5 parts of dried ginger, and 2-10 parts of Spirodela polyrhiza. By mixing these ingredients in specific weight proportions, each ingredient works synergistically to gently cleanse skin of oil and dirt, soothe itching, redness, and sensitivity, effectively inhibit inflammation, improve acne and pimples, promote pigment metabolism, fade acne scars, and brighten skin tone. Through oil control, pore tightening, and barrier repair, it improves enlarged pores, leaving skin smooth and clear.

[0016] Based on the aforementioned technical advantages, this invention also provides a method for preparing the cleansing and astringent wet compress solution. This method involves extracting the solution according to the characteristics of different raw materials, fully preserving the active ingredients, and improving the bioavailability of these active ingredients. Therefore, the cleansing and astringent wet compress solution provided by this invention is green and safe, has a good skin feel, and is highly effective. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 The facial features of patient 1 during the initial diagnosis provided by this invention; Figure 2 The facial condition of patient 1 during a follow-up visit provided by this invention; Figure 3 The initial facial features of patient 2 provided by this invention; Figure 4 The facial condition of patient 2 during a follow-up visit provided by this invention. Detailed Implementation

[0019] In this invention, unless otherwise specified, the raw materials, equipment and methods used are all conventional selections.

[0020] Tribulus terrestris ( Tribulus terrestris L.), the usable part is the dried, ripe fruit; Centella asiatica ( Centella asiatica (L.) Urb.), the whole herb is usable; Kochia scoparia ( Kochia scoparia (L.) Schrad.), the usable part is the dried, ripe fruit; Moutan bark (Paeonia suffruticosa Andr.), the usable part is the dried root bark; Dried ginger ( Zingiber officinale Roscoe The usable part is the dried rhizome; duckweed( Lemna minor The usable part of L. is the dried whole herb.

[0021] To further illustrate the present invention, the solutions provided by the present invention will be described in detail below with reference to the accompanying drawings and embodiments, but these should not be construed as limiting the scope of protection of the present invention.

[0022] Example 1 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica and 5g of duckweed and then crush them to obtain a first crushed material with a particle size <0.1cm. At room temperature (25-30℃), mix the first crushed material with water at a mass ratio of 1:20 and soak for 10min. Then, boil the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, the filtrate and filter residue (labeled as the first filter residue) are obtained. Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate. S2. The first filter residue, water and compound enzyme (bromelain and cellulase were mixed at a mass ratio of 1.8:1 to obtain compound enzyme) from step S1 were mixed at a mass ratio of 1:20:0.01 and enzymatically hydrolyzed at 45℃ for 30 min. After enzyme inactivation treatment, the mixture was centrifuged and filtered. The resulting supernatant was recorded as the enzymatic hydrolysate. S3. Mix 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and freeze at -1℃ for 2 hours. After freezing, pulverize to obtain a second pulverized material (particle size <0.1cm). Mix the second pulverized material with water at a mass ratio of 1:25, decoct at 95-100℃ for 20 minutes, and centrifuge and filter to obtain the filtrate (referred to as the second filtrate) and the residue (referred to as the second residue). S4. At 25-30℃, the second filter residue from step S3 is mixed with glycerol at a mass ratio of 1:2 and soaked for 15 min. Then, the mixture is extracted by high vacuum distillation at 130 mPa for 1 h to obtain the distillate. Combine the first filtrate, the enzymatic hydrolysate, the second filtrate, and the distillate to obtain a cleansing and astringent wet compress solution.

[0023] Example 2 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 5g of Centella asiatica and 8g of duckweed and then crush them to obtain a first crushed material with a particle size <0.1cm. At room temperature (25-30℃), mix the first crushed material with water at a mass ratio of 1:30 and soak for 10min. Then, boil the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, obtain the filtrate and filter residue (labeled as the first filter residue). Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate. S2. The first filter residue, water and compound enzyme (bromelain and cellulase were mixed at a mass ratio of 2.3:1 to obtain compound enzyme) from step S1 were mixed at a mass ratio of 1:20:0.01 and enzymatically hydrolyzed at 45℃ for 30 min. After enzyme inactivation treatment, the mixture was centrifuged and filtered. The resulting supernatant was recorded as the enzymatic hydrolysate. S3. Mix 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 1g of dried ginger, and freeze at -1℃ for 2 hours. After freezing, pulverize to obtain a second pulverized material (particle size <0.1cm). Mix the second pulverized material with water at a mass ratio of 1:25, decoct at 95-100℃ for 20 minutes, and centrifuge and filter to obtain the filtrate (referred to as the second filtrate) and the residue (referred to as the second residue). S4. At 25-30℃, the second filter residue from step S3 is mixed with glycerol at a mass ratio of 1:2 and soaked for 15 min. Then, the mixture is extracted by high vacuum distillation at 130 mPa for 1 h to obtain the distillate. Combine the first filtrate, the enzymatic hydrolysate, the second filtrate, and the distillate to obtain a cleansing and astringent wet compress solution.

[0024] Comparative Example 1 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica, 5g of duckweed, 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and then pulverize them to obtain the first pulverized material with a particle size <0.1cm. At room temperature (25-30℃), mix the first pulverized material with water at a mass ratio of 1:20 and soak for 10min. Then, decoct the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, obtain the filtrate and residue (labeled as the first residue). Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate, which is the cleansing and astringent wet compress solution.

[0025] Comparative Example 2 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica, 5g of duckweed, 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and then pulverize them to obtain a first pulverized material with a particle size <0.1cm. At room temperature (25-30℃), mix the first pulverized material with water at a mass ratio of 1:20 and soak for 10min. Then, decoct the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, obtain the filtrate and the residue (labeled as the first residue). Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate. S2. The first filter residue, water and compound enzyme (bromelain and cellulase were mixed at a mass ratio of 1.8:1 to obtain compound enzyme) from step S1 were mixed at a mass ratio of 1:20:0.01 and enzymatically hydrolyzed at 45℃ for 30 min. After enzyme inactivation treatment, the mixture was centrifuged and filtered. The resulting supernatant was recorded as the enzymatic hydrolysate. Combine the first filtrate and the enzymatic hydrolysate to obtain a cleansing and astringent wet compress solution.

[0026] Comparative Example 3 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica, 5g of duckweed, 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and freeze at -1℃ for 2 hours. After freezing, pulverize to obtain a second pulverized material (particle size <0.1cm). Mix the second pulverized material with water at a mass ratio of 1:25, decoct at 95-100℃ for 20 minutes, and centrifuge and filter to obtain the filtrate (referred to as the second filtrate) and the residue (referred to as the second residue). S2. At 25-30℃, the second filter residue from step S1 is mixed with glycerol at a mass ratio of 1:2 and soaked for 15 min. Then, the mixture is extracted by high vacuum distillation at 130 mPa for 1 h to obtain the distillate. Combine the second filtrate and the distillate to obtain a cleansing and astringent wet compress solution.

[0027] Comparative Example 4 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica and 15g of duckweed and then crush them to obtain a first crushed material with a particle size <0.1cm. At room temperature (25-30℃), mix the first crushed material with water at a mass ratio of 1:20 and soak for 10min. Then, boil the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, the filtrate and filter residue (labeled as the first filter residue) are obtained. Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate. S2. The first filter residue, water and compound enzyme (bromelain and cellulase were mixed at a mass ratio of 1.8:1 to obtain compound enzyme) from step S1 were mixed at a mass ratio of 1:20:0.01 and enzymatically hydrolyzed at 45℃ for 30 min. After enzyme inactivation treatment, the mixture was centrifuged and filtered. The resulting supernatant was recorded as the enzymatic hydrolysate. S3. Mix 1g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and freeze at -1℃ for 2 hours. After freezing, pulverize to obtain a second pulverized material (particle size <0.1cm). Mix the second pulverized material with water at a mass ratio of 1:25, decoct at 95-100℃ for 20 minutes, and centrifuge and filter to obtain the filtrate (referred to as the second filtrate) and the residue (referred to as the second residue). S4. At 25-30℃, the second filter residue from step S3 is mixed with glycerol at a mass ratio of 1:2 and soaked for 15 min. Then, the mixture is extracted by high vacuum distillation at 130 mPa for 1 h to obtain the distillate. Combine the first filtrate, the enzymatic hydrolysate, the second filtrate, and the distillate to obtain a cleansing and astringent wet compress solution.

[0028] Comparative Example 5 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica and 5g of duckweed and then crush them to obtain a first crushed material with a particle size <0.1cm. At room temperature (25-30℃), mix the first crushed material with water at a mass ratio of 1:20 and soak for 10min. Then, boil the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, the filtrate and filter residue (labeled as the first filter residue) are obtained. Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate. S2. The first filter residue, water and compound enzyme (bromelain and cellulase are mixed at a mass ratio of 1:2 to obtain compound enzyme) from step S1 are mixed at a mass ratio of 1:20:0.01 and enzymatically hydrolyzed at 45℃ for 30 min. After enzyme inactivation treatment, the mixture is centrifuged and filtered. The resulting supernatant is recorded as the enzymatic hydrolysate. S3. Mix 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and freeze at -1℃ for 2 hours. After freezing, pulverize to obtain a second pulverized material (particle size <0.1cm). Mix the second pulverized material with water at a mass ratio of 1:25, decoct at 95-100℃ for 20 minutes, and centrifuge and filter to obtain the filtrate (referred to as the second filtrate) and the residue (referred to as the second residue). S4. At 25-30℃, the second filter residue from step S3 is mixed with glycerol at a mass ratio of 1:2 and soaked for 15 min. Then, the mixture is extracted by high vacuum distillation at 130 mPa for 1 h to obtain the distillate. Combine the first filtrate, the enzymatic hydrolysate, the second filtrate, and the distillate to obtain a cleansing and astringent wet compress solution.

[0029] Comparative Example 6 The steps for preparing a cleansing and astringent wet compress solution are as follows: S1. Mix 10g of Centella asiatica and 5g of duckweed and then crush them to obtain a first crushed material with a particle size <0.1cm. At room temperature (25-30℃), mix the first crushed material with water at a mass ratio of 1:20 and soak for 10min. Then, boil the soaked mixture at 95-100℃ for 30min. After centrifugation and filtration, the filtrate and filter residue (labeled as the first filter residue) are obtained. Refrigerate the filtrate at 5℃ for 5h to obtain the first filtrate. S2. The first filter residue, water and compound enzyme (bromelain and cellulase were mixed at a mass ratio of 1.8:1 to obtain compound enzyme) from step S1 were mixed at a mass ratio of 1:20:0.01 and enzymatically hydrolyzed at 45℃ for 30 min. After enzyme inactivation treatment, the mixture was centrifuged and filtered. The resulting supernatant was recorded as the enzymatic hydrolysate. S3. Mix 10g of stir-fried Tribulus terrestris, 10g of Kochia scoparia, 5g of Paeonia suffruticosa, and 3g of dried ginger, and freeze at -1℃ for 2 hours. After freezing, pulverize to obtain a second pulverized material (particle size <0.1cm). Mix the second pulverized material with water at a mass ratio of 1:25, decoct at 95-100℃ for 20 minutes, and centrifuge and filter to obtain the filtrate (referred to as the second filtrate) and the residue (referred to as the second residue). Combine the first filtrate, the enzymatic hydrolysate, and the second filtrate to obtain a cleansing and astringent wet compress solution.

[0030] Antibacterial effect verification Sterilize filter paper discs with a diameter of 6 mm, then soak them in the cleansing and astringent wet compress solutions prepared in Examples 1-2 and Comparative Examples 1-6 for 30 min, remove them and air dry them to obtain drug sensitivity tablets. A suspension of Propionibacterium acnes with a turbidity of 0.5 McFarland units was taken with a sterile cotton swab and evenly spread on a plate. After drying, drug sensitivity tablets of Examples 1-2 and Comparative Examples 1-6 were attached to the plate. The plate was anaerobically incubated at 37°C for 48 hours. The diameter of the inhibition zone of the drug sensitivity tablet was measured by the cross-sectional method. The diameter of the inhibition zone was obtained by subtracting 6 mm from the measured diameter. A sterile cotton swab was used to collect samples with an effective live bacteria count of 10. 5 CFU / mL Staphylococcus aureus bacterial suspension was evenly spread on a plate. After drying, drug sensitivity tablets of Examples 1-2 and Comparative Examples 1-6 were attached to the plate. The plate was incubated at 37°C for 24 hours. The diameter of the inhibition zone of the drug sensitivity tablet was measured by the cross-sectional method. The diameter of the inhibition zone was obtained by subtracting 6 mm from the measured diameter. A sterile cotton swab was used to collect samples with an effective live bacteria count of 10. 5CFU / mL Staphylococcus epidermidis bacterial suspension was evenly spread on a plate. After drying, drug sensitivity tablets of Examples 1-2 and Comparative Examples 1-6 were attached to the plate. The plate was incubated at 37°C for 24 hours. The diameter of the inhibition zone of the drug sensitivity tablet was measured by the cross-sectional method. The diameter of the inhibition zone was obtained by subtracting 6 mm from the measured diameter. Each bacterial culture was considered as one treatment, and each treatment was performed in three parallel replicates (the mean value was taken). The results are shown in Table 1.

[0031] Table 1. Diameter of inhibition zones under different treatments

[0032] As can be seen from the data in Table 1, the cleansing and astringent wet compresses prepared in Examples 1 and 2 all exhibit good inhibitory effects against Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Therefore, the above-mentioned cleansing and astringent wet compresses can effectively inhibit and kill bacteria, cleanse and care for damaged skin, and achieve the purpose of treating acne.

[0033] Itch relief efficacy verification The astringent and purifying wet compress solutions prepared in Examples 1, 2, 1, and 5 were selected as test solutions for the following verification: Fifty Kunming mice (half male and half female) were randomly divided into 5 groups: Example 1 group, Example 2 group, Comparative Example 1 group, Comparative Example 5 group, and blank control group. The backs of the mice in each group were shaved without damaging the skin (shaved area 3×3cm). 1.5mL of the test solution was applied to the shaved area of ​​each mouse (applied according to the mouse group; the blank group received an equal volume of sterile water). After 1 hour, if no abnormalities were observed, each mouse was subcutaneously injected with 0.01ml·g of the test solution into its back. -1 A 0.02% 4-aminopyridine solution (prepared with physiological saline) was used. The scratching latency and the number of scratching responses in mice within 30 minutes were recorded. The results are shown in Table 2.

[0034] Table 2. Effects of different treatments on antipruritic effects in mice.

[0035] As shown in Table 2, after using the penetrating and astringent wet compress solution prepared in Examples 1 and 2 of this invention, even with subcutaneous injection of 4-aminopyridine solution into mice, the scratching latency period was effectively prolonged and the number of scratching responses was reduced. Therefore, the penetrating and astringent wet compress solution provided by this invention has a good antipruritic effect and can be used to relieve itching caused by various reasons.

[0036] Whitening efficacy verification The astringent and purifying wet compress solutions prepared in Examples 1, 2, 1, and 5 were selected as test solutions for the following verification: Thirty healthy, brown-yellow guinea pigs weighing 240-260g at 10 weeks of age were selected and, after acclimatization without abnormalities, were randomly divided into 5 groups of 6 each. The groups were labeled as: Example 1 group, Example 2 group, Comparative Example 1 group, Comparative Example 5 group, and blank control group. Hair was removed from the backs of guinea pigs in each group, with a hair removal area of ​​4cm×4cm. The L value of the skin area on the back of each treated guinea pig was measured using a colorimeter, and the mean L value of each group was recorded (referred to as the L value before verification). Two mL of the above-mentioned test solution was applied to the skin of each guinea pig's hair-removed area (applied according to the guinea pig group). Mice in the blank control group were applied with an equal volume of sterile water. Application was repeated once daily for 30 consecutive days (new hair growth in the hair-removed area was monitored and treated as needed during the experiment). On days 3, 5, 7, and 9 after application, the hair-removed area on the guinea pig's back was irradiated with UVB light (i.e., 4 irradiations). The specific procedure was as follows: UVB light irradiation was performed 2 hours after application, with the lamp 15 cm away from the back, a UV wavelength of 280-320 nm, and a total irradiation dose of 200 mJ / cm² per session. 2 Thirty days after medication, the L value of the skin area on the back of each treatment guinea pig was measured using a colorimeter, and the mean L value of each group was recorded (referred to as the L value after validation). The change in L value (ΔL) for each treatment was calculated as L value after validation - L value before validation. The results are shown in Table 3.

[0037] Table 3. Effects of different treatments on skin brightening and whitening effects

[0038] Based on the data in Table 3, it can be seen that, compared with the comparative example and the blank control, the clearing and astringent wet compress prepared in Examples 1 and 2 can significantly improve UV-induced skin pigmentation in mice and can be used to brighten skin tone or to prepare whitening products.

[0039] Safety test Using the 2015 "Cosmetic Safety Technical Specifications" as a reference standard, Example 1 was analyzed. The prepared astringent and purifying compress solution was evaluated for cosmetic irritation, with an age of 16 years and above as the baseline. The following test was conducted on a sample of 50 people aged 65 and older: Test method: Place the test substance into the spot tester (the amount used is 0.020). (0.025 mL) The patch applicator containing the test substance is applied to the back or flexor side of the forearm of the subject using non-irritating cloth adhesive tape. Gently press with the palm of the hand to ensure even adhesion to the skin surface. Leave on for 24 hours. Remove the patch applicator 30 minutes after the pressure mark disappears and observe the skin reaction. If the result is negative, repeat the observation at 24 hours and 48 hours after the patch test.

[0040] Evaluation criteria: Grade 0: Negative reaction; Grade 1: Suspicious reaction, with only slight erythema; Grade 2: Weak positive reaction, erythema, infiltration, edema, and possible papules; Grade 3: Strong positive reaction, erythema, infiltration, edema, papules may be present, and the reaction may extend beyond the test area; Grade 4: Extremely positive reaction, with obvious erythema, severe infiltration, edema, confluent herpes, and reaction extending beyond the test area.

[0041] Test results: All subjects showed negative skin reactions. This demonstrates that the cleansing and astringent compress solutions prepared in Examples 1 and 2 are gentle and non-irritating to the skin, and safe to use.

[0042] Verification of pore-shrinking effect Thirty volunteers aged 22-35 (15 males and 15 females) were selected. Requirements included: visible blackheads, no history of skin diseases or allergies, and no use of cosmetics for two days prior to and during the verification process. These volunteers were randomly divided into three groups (Example 1 group, Example 2 group, and blank control group). The cleansing and astringent compress solution prepared in Examples 1 and 2 was used. A compress cloth was completely soaked in the solution for 10 minutes, and then applied to the face for 5-10 minutes, 3-4 times per week for two consecutive months. The blank control group used water instead of the cleansing and astringent compress solution.

[0043] The nose area of ​​volunteers was selected as the test site (pores were photographed at the same location). The pore size was measured with a skin image analyzer. The mean pore size before using the cleansing and astringent compress was recorded as the previous mean, and the mean pore size after using the cleansing and astringent compress was recorded as the next mean. The difference between the previous mean and the next mean was calculated. The results are shown in Table 4.

[0044] Table 4. Effects of different treatments on pore size

[0045] As shown in Table 4, after using the cleansing and astringent compress solutions from Examples 1 and 2, the pore size of the skin decreased, while the pore size in the blank control tended to increase. Therefore, the cleansing and astringent compress solution provided by this invention has a significant effect on shrinking pores.

[0046] Clinical efficacy (1) Patient Guo XX, male, 26 years old, programmer.

[0047] Initial diagnosis (before use): Primarily acne on the forehead, face, and cheeks, with yellow pustules, redness, swelling, itching, no pain, large pores, and oily skin. Figure 1 ).

[0048] After cleansing, apply the cleansing and astringent compress solution prepared in Example 1 to the face for 5-10 minutes, once a day. Store the compress solution in the refrigerator and use it immediately.

[0049] Two weeks later, at the follow-up visit, the patient's acne had significantly improved. There were no new pimples, no pus, no itching, and the skin tone was clear and bright, with reduced oil production from the pores. In other words, compared to the initial visit, the patient's acne scars were lighter, there was no redness or swelling, and the shine was less. Figure 2 ).

[0050] (2) Patient Li XX, female, 21 years old, is a college student.

[0051] Initial diagnosis (before use): Facial acne, mainly on the nose and cheeks, red, swollen, painful, itchy, hard to the touch, with pustules, large pores, and excessive oil production. A few small whiteheads (about the size of rice grains) on the forehead and chin. Figure 3 ).

[0052] After cleansing, apply the cleansing and astringent compress solution prepared in Example 1 to the face for 5-10 minutes, once a day. Store the compress solution in the refrigerator and use it immediately.

[0053] Two weeks later, at the follow-up visit, the patient's facial acne had significantly improved, with no new acne, no tenderness upon pressure, no redness or itching, finer pores, and a clear complexion. The patient reported that makeup did not cake or cake and that her skin was not oily. Figure 4 ).

[0054] In summary, this invention combines roasted Tribulus terrestris, Centella asiatica, Kochia scoparia, Paeonia suffruticosa, dried ginger, and duckweed. The ingredients work synergistically to gently cleanse skin of oil and dirt, soothe itching, redness, and sensitivity, effectively inhibit inflammation, improve acne and pimples, promote pigment metabolism, fade acne scars, and brighten skin tone. Through oil control, pore tightening, and barrier repair, it improves enlarged pores, leaving skin smooth and clear. This product is green, safe, has a pleasant feel, and is highly effective.

[0055] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A cleansing and astringent wet compress solution, characterized in that, By weight, it includes the following raw materials: Stir-fried Tribulus terrestris 5-20 parts, Centella asiatica 5-20 parts, Kochia scoparia 5-15 parts, Paeonia suffruticosa 5-10 parts, dried ginger 1-5 parts, and duckweed 2-10 parts.

2. The cleansing and astringent wet compress solution according to claim 1, characterized in that, By weight, it includes the following raw materials: 10 parts stir-fried Tribulus terrestris, 10 parts Centella asiatica, 10 parts Kochia scoparia, 5 parts Paeonia suffruticosa, 3 parts dried ginger, and 5 parts duckweed.

3. The method for preparing the cleansing and astringent wet compress solution according to claim 1 or 2, characterized in that, Includes the following steps: S1 mixes and crushes Centella asiatica and duckweed to obtain a first crushed material; mixes the first crushed material with water for soaking, first decoction, and filtration to obtain filtrate and first residue; refrigerates the filtrate to obtain a first filtrate. S2 involves mixing the first filter residue, water, and compound enzyme for enzymatic hydrolysis, enzyme inactivation, and filtration to obtain the enzymatic hydrolysate. The complex enzyme includes: bromelain and cellulase; S3 mixes stir-fried Tribulus terrestris, Kochia scoparia, Paeonia suffruticosa and dried ginger, freezes and pulverizes them to obtain a second pulverized material; mixes the second pulverized material with water for a second decoction and filtration to obtain a second residue and a second filtrate; S4 mixes and soaks the second filter residue with glycerin, then extracts it by high-vacuum distillation to obtain the distillate; combine the first filtrate, enzymatic hydrolysate, distillate and second filtrate to obtain the cleansing and astringent wet compress solution.

4. The preparation method according to claim 3, characterized in that, In step S1, the mass ratio of the first pulverized material to water is 1:20-30; the first decoction time is 30-40 minutes, and the temperature is 85-100℃.

5. The preparation method according to claim 3, characterized in that, In step S2, the mass ratio of the first filter residue, water, and compound enzyme is 1:15-20:0.01-0.03; in the compound enzyme, the mass ratio of bromelain and cellulase is 1.8-2.3:

1. The enzymatic hydrolysis is performed at a temperature of 45-52℃ for 30-45 minutes.

6. The preparation method according to claim 3, characterized in that, In step S3, the mass ratio of the second pulverized material to water is 1:15-25; the second decoction time is 20-30 minutes, and the temperature is 85-100℃.

7. The preparation method according to claim 3, characterized in that, In step S4, the second filter residue is mixed with glycerol at a mass ratio of 1:2-3 and soaked for 10-15 minutes at 25-30℃. The vacuum degree of the high-vacuum distillation extraction is 110-130 mPa, and the time is 1-1.5 h.

8. The preparation method according to claim 3, characterized in that, In step S1, the refrigeration temperature is 5-10℃, and the time is 3-5 hours; In step S3, the mixed raw materials are frozen at -10°C to -1°C for 1-2 hours.

9. The use of the cleansing and astringent wet compress liquid according to claim 1 or 2 in the preparation of skin care products.

10. The application according to claim 9, characterized in that, The skin care product has at least one of the following effects (1)-(3): (1) Cleanses and relieves itching; (2) Acne removal and skin whitening; (3) Shrink pores.

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