A traditional Chinese medicine composition for warming meridians, dispelling cold, strengthening muscles and relieving pain

Abstract

This invention relates to the field of external Chinese medicine preparations, and particularly to a topical Chinese medicine composition for warming the meridians, dispelling cold, strengthening tendons, and relieving pain. The composition includes removing impurities from various Chinese medicinal materials, drying and sterilizing them, then pulverizing and sieving them to obtain fine powder. The obtained fine powder is mixed evenly according to a formula ratio, and a composite carrier formed by Artemisia argyi charcoal micropowder, halloysite nanotubes, and hydroxypropyl-cyclodextrin is added for adsorption and encapsulation. This is then mixed evenly with a topical matrix to prepare patches, ointments, gels, powders, or hot compresses. This invention combines warming and meridian-clearing herbs such as processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum carmichaelii with blood-activating and pain-relieving herbs such as frankincense, myrrh, and Corydalis yanhusuo, and controls their synergistic relationship as topical active components. Under skin administration, it can simultaneously warm the meridians, dispel cold, and promote qi circulation and blood circulation, helping to improve discomfort such as cold pain, soreness, and stiffness caused by cold-dampness stagnation and meridian obstruction. This results in a more complete, continuous, and clearly defined warming and regulating effect compared to a single analgesic formula.

Description

Technical Field

[0001] This invention relates to the field of external preparations of traditional Chinese medicine, and in particular to an external traditional Chinese medicine composition for warming the meridians, dispelling cold, strengthening muscles and tendons and relieving pain. Background Technology

[0002] This external herbal composition for warming the meridians, dispelling cold, strengthening muscles and relieving pain is a type of compound external preparation based on the theories of external treatment and the differentiation and treatment of arthralgia in Traditional Chinese Medicine. Traditional Chinese Medicine believes that discomfort in the neck, shoulders, waist, and legs, joint soreness, numbness in the limbs, and muscle and bone strain are mostly related to the invasion of wind, cold, and dampness, cold stagnation in the meridians, poor blood and qi circulation, as well as liver and kidney deficiency and malnourishment of muscles and bones. Treatment typically focuses on a combination of warming the meridians and dispelling cold, eliminating wind and dampness, promoting blood circulation and unblocking collaterals, relaxing muscles and relieving pain, and strengthening muscles and bones. This external herbal composition can be applied to the local skin, muscles, fascia, joints, and related meridians through methods such as plastering, hot compresses, rubbing, and mixing, allowing the medicine to be continuously released on the body surface and exert local warming, muscle-relaxing, and pain-relieving effects.

[0003] These compositions typically use traditional Chinese medicines with properties such as warming yang and dispelling cold, dispelling wind and dampness, promoting blood circulation and removing blood stasis, clearing the channels and relieving pain, and tonifying the liver and kidneys. They can be formulated into external forms such as patches, ointments, gels, poultices, powders, medicated packs, hot compresses, or creams, depending on the need. With the development of modern transdermal drug delivery and topical formulation technologies, topical Chinese medicine products are widely used in daily conditioning and auxiliary intervention scenarios such as cervical spine, lumbar spine, knee joint, shoulder periarthritis, rheumatic pain, chronic strain, and muscle and bone pain.

[0004] Existing topical Chinese medicine compositions for neck, shoulder, back, and leg pain, joint soreness, limb numbness, and muscle and bone strain mostly focus on simply promoting blood circulation and relieving pain or dispelling wind and dampness. They lack sufficient warming and dispersing effects, making it difficult to address deep-seated cold and dampness, old blood stasis, blocked meridians, and malnutrition of muscles and bones. Furthermore, they lack a combination system that integrates tonification and purgation, and combines dispersing and consolidation. The sustained conditioning effect on pain in multiple areas, fascia stiffness, limited joint movement, and recurring strain still needs improvement. Summary of the Invention

[0005] In order to solve the problems mentioned in the background art, the present invention provides a topical Chinese medicine composition for warming the meridians, dispelling cold, strengthening tendons and relieving pain.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A topical traditional Chinese medicine composition for warming the meridians, dispelling cold, strengthening muscles and tendons, and relieving pain, wherein the topical traditional Chinese medicine composition comprises active traditional Chinese medicine components, wherein the active traditional Chinese medicine components comprise, by weight: Frankincense 3-15 parts, Myrrh 3-15 parts, Prepared Aconite Root 0.5-5 parts, Stir-fried Atractylodes Rhizome 3-20 parts, Prepared Aconitum Carmichaelii 0.5-5 parts, Prepared Aconitum Root 0.5-5 parts, Saposhnikovia Root 3-15 parts, Notopterygium Root 3-15 parts, Angelica Pubescens Root 3-15 parts, Corydalis Rhizome 3-20 parts, Raw Coix Seed 5-30 parts, Trachelospermum Villosum 5-30 parts, Carthamus Root 2-15 parts, Spatholobus Stem 5-35 parts, Drynaria Rhizome 5-30 parts, Mulberry Twig 5-35 parts, Piper Rhizome 5-30 parts, Acanthopanax Bark 3-20 parts, Taxillus Rhizome 5-35 parts, Achyranthes Root 3-25 parts, Dipsacus Root 5-30 parts, Raw Eucommia Bark 5-30 parts, Liquidambar Fruit 3-20 parts, Chaenomeles Root 3-25 parts, Clematis Root 3-20 parts; Among them, the prepared aconite root, processed aconite root, and processed aconite root are all processed products, and the total weight of the prepared aconite root, processed aconite root, and processed aconite root accounts for 1%-8% of the total weight of the active ingredients of the traditional Chinese medicine.

[0007] Furthermore, the active components of the traditional Chinese medicine, by weight, include: Frankincense 5-10 parts, Myrrh 5-10 parts, Black aconite 1-3 parts, Fried Atractylodes lancea 6-12 parts, Processed Aconitum carmichaelii 1-3 parts, Processed Aconitum kusnezoffii 1-3 parts, Saposhnikovia divaricata 5-10 parts, Notopterygium incisum 5-10 parts, Angelica pubescens 5-10 parts, Corydalis yanhusuo 6-12 parts, Raw Coix lacryma-jobi 10-20 parts, Trachelospermum jasminoides 8-18 parts, Carthamus tinctorius 3-8 parts, Spatholobus suberectus 10-25 parts, Drynaria fortunei 8-18 parts, Morus alba twigs 10-25 parts, Piper kadsura 8-18 parts, Acanthopanax senticosus 6-15 parts, Taxillus chinensis 10-25 parts, Achyranthes bidentata 6-15 parts, Dipsacus asper 8-18 parts, Raw Eucommia ulmoides 8-18 parts, Liquidambar formosana 5-12 parts, Chaenomeles speciosa 6-15 parts, Clematis chinensis 5-12 parts.

[0008] Furthermore, the active components of the traditional Chinese medicine include a group for warming yang and dispelling cold and relieving pain, a group for dispelling wind and eliminating dampness, a group for promoting blood circulation and unblocking collaterals, and a group for strengthening tendons and consolidating the foundation; The warming and dispersing cold and relieving pain group consists of prepared aconite root, prepared aconite root, black aconite slices, frankincense, myrrh and corydalis rhizome; The wind-dispelling and dampness-removing group consists of stir-fried Atractylodes lancea, Saposhnikovia divaricata, Notopterygium incisum, Angelica pubescens, raw Coix lacryma-jobi, and Clematis chinensis. The blood-activating and meridian-clearing group consists of Trachelospermum jasminoides, Carthamus tinctorius, Spatholobus suberectus, Morus alba twigs, Piper kadsura, Achyranthes bidentata, and Liquidambar formosana. The strengthening and consolidating group consists of Drynaria fortunei, Acanthopanax senticosus, Taxillus chinensis, Dipsacus asper, Eucommia ulmoides, and Chaenomeles speciosa.

[0009] Furthermore, the weight ratio of the warming and dispersing cold and relieving pain group, the wind-dispelling and dampness-removing group, the blood-activating and meridian-clearing group, and the muscle-strengthening and foundation-consolidating group is as follows: 1∶1-3∶1.5-4∶1.2-4.

[0010] Furthermore, the combined weight of the prepared aconite root, prepared aconite root, and prepared aconite root accounts for 1.5%-5% of the total weight of the active ingredients of the traditional Chinese medicine.

[0011] Furthermore, the topical Chinese medicine composition also includes a sustained-release carrier, which comprises a composite carrier formed by Artemisia argyi charcoal micropowder, halloysite nanotubes, and hydroxypropyl-cyclodextrin.

[0012] Furthermore, the mass ratio of the charcoal micropowder, halloysite nanotubes, and hydroxypropyl-cyclodextrin is 1:0.5-5:1-8.

[0013] Furthermore, the external Chinese medicine composition also includes an external matrix, which includes one or more of the following: hydrogel matrix, ointment matrix, poultice matrix, coating matrix, cream matrix, and powder application matrix; The external Chinese medicine composition is a patch, ointment, gel, poultice, film, powder, hot compress, medicine pack, cream, or external film.

[0014] The beneficial effects of this invention are: This invention combines warming and meridian-clearing drugs such as processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum carmichaelii with blood-activating and pain-relieving drugs such as frankincense, myrrh, and Corydalis yanhusuo, and controls their synergistic relationship as active components for external use. Under the condition of skin administration, it can take into account both warming the meridians and dispelling cold and promoting qi and removing blood stasis. It helps to improve discomfort such as cold pain, soreness, and stiffness caused by cold and damp stagnation and meridian obstruction. Compared with single analgesic formulas, it has a more complete, continuous and clearer warming and regulating effect.

[0015] This invention combines stir-fried Atractylodes lancea, Saposhnikovia divaricata, Notopterygium incisum, Angelica pubescens, raw Coix lacryma-jobi, Clematis chinensis, Trachelospermum jasminoides, Spatholobus suberectus, Carthamus tinctorius, Morus alba twigs, Piper kadsura, Achyranthes bidentata, and Liquidambar formosana to form a drug combination that emphasizes both dampness removal and meridian unblocking. It can simultaneously dispel wind and dampness, promote blood circulation and unblock meridians, and relax muscles and joints. This helps to improve the coverage and applicability of discomfort in joints, fascia, and meridians of the limbs, and enhances the integrity and continuity of external conditioning.

[0016] This invention further incorporates tonifying and strengthening herbs such as Drynaria fortunei, Acanthopanax senticosus, Taxillus chinensis, Dipsacus asper, Eucommia ulmoides, and Chaenomeles speciosa. After pulverizing and mixing these herbs, a topical composition suitable for application, hot compress, or mixed application is prepared. This composition can provide both warming and pain relief while also nourishing the muscles and bones and soothing tendons. It helps to improve the problems of insufficient tonifying and strengthening properties and limited applicability of existing formulas, making the product more flexible in application scenarios and with a more complete formulation logic. Detailed Implementation

[0017] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are some embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] This invention discloses a topical Chinese medicine composition for warming the meridians, dispelling cold, strengthening muscles and relieving pain. It is applied to external conditioning scenarios such as discomfort in the neck, shoulders, waist and legs, joint soreness, muscle and bone strain, cold and dampness arthralgia, numbness of limbs and local stiffness. The composition includes steps of removing impurities and drying medicinal materials, pulverizing and mixing medicinal materials, loading of composite carrier, and preparation of external matrix. The invention will be further disclosed below with reference to the specific preparation process.

[0019] The main equipment used in this specific embodiment includes an electronic balance, a medicinal material cleaning table, a hot air circulating drying oven, an ultraviolet sterilization device, an ultrafine pulverizer, a vibrating screen, a three-dimensional mixer, a vacuum mixer, a coating machine, a slicer, and a packaging machine. The testing equipment used in the efficacy verification test includes an electronic Von Frey mechanical pain threshold meter, a hot plate analgesia meter, a foot volume meter or vernier calipers, a small animal grip strength meter, and a skin irritation observation and scoring device. All of the above equipment can be conventional equipment in this field.

[0020] Example 1: This example provides a topical Chinese medicine composition for warming the meridians, dispelling cold, strengthening tendons, and relieving pain. By weight, the following ingredients are weighed: 8 parts frankincense, 8 parts myrrh, 0.5 parts black aconite root slices, 8 parts stir-fried atractylodes rhizome, 0.5 parts prepared aconite root, 0.5 parts prepared aconite root, 6 parts saposhnikovia root, 6 parts notopterygium root, 5 parts angelica root, 9.5 parts corydalis rhizome, 6 parts raw coix seed, 8 parts trachelospermum jasminoides, 3 parts safflower, 8 parts chicken blood vine, 8 parts drynaria rhizome, 10 parts mulberry twig, 7 parts sea breeze vine, 5 parts eleutherococcus bark, 8 parts mulberry mistletoe, 5 parts achyranthes root, 8 parts dipsacus root, 8 parts raw eucommia bark, 4 parts luffa rhizome, 6 parts papaya, and 4 parts clematis root.

[0021] Among them, processed aconite root, processed aconite tuber, and processed aconite root are all processed medicinal materials, totaling 1.5 parts. The total amount of active ingredients in traditional Chinese medicine is 150 parts, and the total weight of the three accounts for 1.0% of the total weight of active ingredients in traditional Chinese medicine. The weight ratio of the warming and dispersing cold and relieving pain group, the wind-dispelling and dampness-removing group, the blood-activating and collaterals-dredging group, and the muscle-strengthening and foundation-consolidating group is approximately 1:1.30:1.67:1.59.

[0022] After removing impurities from the above-mentioned medicinal materials, they are dried in a hot air circulating drying oven to a state suitable for pulverization. After ultraviolet sterilization, they are sent to an ultra-micro pulverizer for pulverization. After pulverization, they are sieved to obtain ultra-micro powder of traditional Chinese medicine. The obtained ultra-micro powder of traditional Chinese medicine is placed in a three-dimensional mixer to mix, so that the powders of each medicinal material are evenly dispersed to obtain the active components of traditional Chinese medicine.

[0023] Separately, Artemisia argyi charcoal powder, halloysite nanotubes, and hydroxypropyl-cyclodextrin were mixed in a mass ratio of 1:0.5:1 to obtain a composite carrier. 10% of the mass of the active components of the traditional Chinese medicine was added to the composite carrier. After vacuum stirring, some volatile components, resinous components, and alcohol-soluble components were adsorbed or encapsulated by the composite carrier. A hydrogel matrix was then added, stirred evenly, and coated onto a backing material. An anti-adhesive layer was then applied, sliced, and packaged to obtain a topical traditional Chinese medicine composition for warming the meridians, dispelling cold, strengthening muscles, and relieving pain in the form of a patch.

[0024] This embodiment corresponds to the left endpoint of the total ratio of black aconite slices, processed aconite root, and processed aconite root in the claims, as well as the left endpoint of the mass ratio of charcoal powder, halloysite nanotubes, and hydroxypropyl-cyclodextrin.

[0025] Example 2 differs from Example 1 in that the active components of the traditional Chinese medicine in this example include, by weight, the following: 8 parts frankincense, 8 parts myrrh, 2 parts black aconite root slices, 10 parts stir-fried atractylodes lancea, 2 parts processed aconite root, 2 parts processed aconite tuber, 8 parts saposhnikovia root, 8 parts notopterygium root, 8 parts angelica pubescens root, 10 parts corydalis rhizome, 15 parts raw coix seed, 15 parts trachelospermum jasminoides, 5 parts safflower, 18 parts chicken blood vine, 15 parts drynaria rhizome, 15 parts mulberry twig, 12 parts sea breeze vine, 10 parts eleutherococcus bark, 18 parts mulberry mistletoe, 10 parts achyranthes bidentata root, 15 parts dipsacus root, 15 parts raw eucommia bark, 8 parts luffa fruit, 10 parts papaya, and 8 parts clematis root.

[0026] In this embodiment, the total amount of active ingredients of traditional Chinese medicine is 255 parts, with processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum kusnezoffii totaling 6 parts, accounting for approximately 2.35% of the total weight of active ingredients. The weight ratio of the warming and dispersing cold and relieving pain group, the wind-dispelling and dampness-removing group, the blood-activating and collaterals-unblocking group, and the muscle-strengthening and foundation-consolidating group is approximately 1:1.78:2.59:2.59. The mass ratio of Artemisia argyi charcoal powder, halloysite nanotubes, and hydroxypropyl-cyclodextrin is 1:2:4, and the amount of composite carrier added is 10% of the mass of active ingredients of traditional Chinese medicine. Other steps are the same as in Example 1.

[0027] This embodiment corresponds to the preferred ratio point within the scope of the claims, and is used to illustrate the implementation method when each functional drug group and the composite carrier are in a relatively balanced state.

[0028] Example 3 differs from Example 1 in that the active components of the traditional Chinese medicine in this example include, by weight, the following: 6 parts frankincense, 6 parts myrrh, 5 parts black aconite, 8 parts stir-fried atractylodes, 5 parts processed aconite root, 5 parts processed aconite root, 6 parts saposhnikovia root, 6 parts notopterygium root, 6 parts angelica root, 8 parts corydalis rhizome, 8 parts raw coix seed, 8 parts trachelospermum jasminoides, 4 parts safflower, 10 parts chicken blood vine, 8 parts drynaria rhizome, 14 parts mulberry twig, 10 parts sea breeze vine, 6 parts eleutherococcus bark, 11.5 parts mulberry mistletoe, 8 parts achyranthes root, 10 parts dipsacus root, 10 parts raw eucommia bark, 6 parts luffa rhizome, 9 parts papaya, and 4 parts clematis root.

[0029] In this embodiment, the total amount of active ingredients of traditional Chinese medicine is 187.5 parts, of which processed aconite root, processed cassia bark, and processed cassia tsao-ko comprise 15 parts, accounting for 8.0% of the total weight of active ingredients of traditional Chinese medicine. The weight ratio of the warming and dispersing cold and relieving pain group, the wind-dispelling and dampness-removing group, the blood-activating and collaterals-unblocking group, and the muscle-strengthening and foundation-consolidating group is approximately 1:1.09:1.71:1.56. The mass ratio of artemisia argyi charcoal powder, halloysite nanotubes, and hydroxypropyl-cyclodextrin is 1:5:8, and the amount of composite carrier added is 10% of the mass of active ingredients of traditional Chinese medicine. Other steps are the same as in Example 1.

[0030] This embodiment corresponds to the right end of the total ratio of black aconite slices, processed aconite root, and processed aconite root in the scope of the claims, as well as the right end of the mass ratio of charcoal powder, halloysite nanotubes, and hydroxypropyl-cyclodextrin.

[0031] Comparative Example 1 differs from Example 2 in that it does not include processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum kusnezoffii, and instead uses an equal amount of raw Coix lacryma-jobi and stir-fried Atractylodes lancea to make up the corresponding mass. The composition of other medicinal materials, the ratio of the composite carrier, the external matrix, and the preparation steps are the same as in Example 2.

[0032] Comparative Example 2 differs from Example 2 in that it does not include Drynaria fortunei, Acanthopanax senticosus, Taxillus chinensis, Dipsacus asper, Eucommia ulmoides, and Chaenomeles speciosa, and uses an equal amount of inert medicinal starch to make up the corresponding mass. The composition of other medicinal materials, the ratio of the composite carrier, the external matrix, and the preparation steps are the same as in Example 2.

[0033] Comparative Example 3 differs from Example 2 in that it does not include the composite carrier formed by charcoal powder, halloysite nanotubes and hydroxypropyl-cyclodextrin, and instead uses an equal amount of hydrogel matrix to make up the corresponding mass. The composition of other medicinal materials, external matrix and preparation steps are the same as in Example 2.

[0034] Efficacy verification experiment: SPF-grade SD rats were used to establish a combined cold-dampness arthralgia model and were randomly divided into four groups: Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, and Comparative Example 3, with 10 rats in each group. All groups received topical administration with the same area, unit drug loading, and application time for 7 consecutive days. After the administration period, mechanical paw withdrawal threshold, thermal pain latency, joint swelling rate, grip strength retention rate, and skin irritation score were measured.

[0035] The mechanical withdrawal threshold was measured using an electronic Von Frey mechanical pain threshold meter; the thermal pain latency was measured using a hot plate analgesia meter; the joint swelling rate was measured using a foot volume meter or vernier calipers; the grip strength retention rate was measured using a small animal grip strength meter; and the skin irritation score was observed and evaluated based on the erythema, edema, and local reaction at the application site. Higher mechanical withdrawal threshold, thermal pain latency, and grip strength retention rate indicate better evaluation results; lower joint swelling rate and skin irritation score indicate better evaluation results. The test results are shown in the table below.

[0036] Table 1. Evaluation results of the topical effects of Examples 1 to 3 and Comparative Examples 1 to 3; As shown in Table 1, Examples 1, 2, and 3 are superior to Comparative Examples 1 to 3 in terms of mechanical foot retraction threshold, thermal pain latency, joint swelling rate, and grip strength retention rate. This indicates that the formulations within the scope of the claims can achieve the basic effects of external application in warming the meridians and dispelling cold, promoting blood circulation and relieving pain, and conditioning muscles and bones. Among them, the overall results of Example 2 are better, indicating that when the total ratio of processed aconite, processed Sichuan aconite, and processed cassia aconite is within the preferred range, and the ratio of the composite carrier is at the intermediate preferred point, a relatively coordinated compatibility can be formed between warming and promoting blood circulation, relieving pain, dispelling wind and dampness, strengthening muscles and bones, and sustained-release loading.

[0037] Example 1 uses a left-end ratio, and the total proportions of black aconite slices, processed aconite root, and processed aconite root, as well as the proportions of halloysite nanotubes and hydroxypropyl-cyclodextrin in the composite carrier, are all at a low level. Its various indicators are still better than the comparative example, indicating that the low-end ratio can meet the basic implementation requirements of the present invention. However, due to the relatively weak loading capacity of the warm and heat-clearing group and the composite carrier, the degree of improvement in mechanical foot retraction threshold, heat pain latency, and joint swelling rate is lower than that in Example 2.

[0038] Example 3 uses a right-end ratio, with a higher total proportion of processed Aconitum carmichaelii, processed Aconitum kusnezoffii, and processed Aconitum kusnezoffii. The proportion of halloysite nanotubes and hydroxypropyl-cyclodextrin in the composite carrier is also higher. Its analgesic and anti-swelling evaluation results are still better than the comparative example, indicating that the right-end ratio can still achieve the basic technical effect of the present invention. However, due to the higher proportion of warming and activating drugs, the skin irritation score is higher than that of Example 1 and Example 2. In addition, the excessively high proportion of composite carrier may have a certain impact on the drug release rate. Therefore, the overall effect is slightly lower than that of Example 2.

[0039] Comparative Example 1, which did not include processed Aconitum carmichaelii, processed Aconitum kusnezoffii, or processed Aconitum kusnezoffii, showed lower mechanical foot retraction threshold and thermal pain latency than Example 2, but a relatively higher joint swelling rate. This indicates that warming and invigorating drugs have significant compatibility in improving cold-dampness stagnation, meridian obstruction, and related discomfort from local cold pain. Comparative Example 2, which did not include Drynaria fortunei, Acanthopanax senticosus, Taxillus chinensis, Dipsacus asper, Eucommia ulmoides, or Chaenomeles speciosa, showed a significant decrease in grip strength retention, indicating that the muscle-strengthening group has a positive effect on maintaining limb function, muscle and bone support, and treating strain. Comparative Example 3, which did not include Artemisia argyi charcoal powder, halloysite nanotubes, or a hydroxypropyl-cyclodextrin composite carrier, showed lower analgesic, anti-swelling, and skin irritation scores than Example 2. This indicates that the composite carrier helps to adsorb, encapsulate, and slowly release the active ingredients of traditional Chinese medicine, thereby improving the persistence of external application and reducing the tendency for local burst release to cause irritation.

[0040] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A topical traditional Chinese medicine composition for warming the meridians, dispelling cold, strengthening muscles and tendons, and relieving pain, characterized in that, The external application traditional Chinese medicine composition includes active traditional Chinese medicine components, which, by weight, comprise: Frankincense 3-15 parts, Myrrh 3-15 parts, Prepared Aconite Root 0.5-5 parts, Stir-fried Atractylodes Rhizome 3-20 parts, Prepared Aconitum Carmichaelii 0.5-5 parts, Prepared Aconitum Root 0.5-5 parts, Saposhnikovia Root 3-15 parts, Notopterygium Root 3-15 parts, Angelica Pubescens Root 3-15 parts, Corydalis Rhizome 3-20 parts, Raw Coix Seed 5-30 parts, Trachelospermum Villosum 5-30 parts, Carthamus Root 2-15 parts, Spatholobus Stem 5-35 parts, Drynaria Rhizome 5-30 parts, Mulberry Twig 5-35 parts, Piper Rhizome 5-30 parts, Acanthopanax Bark 3-20 parts, Taxillus Rhizome 5-35 parts, Achyranthes Root 3-25 parts, Dipsacus Root 5-30 parts, Raw Eucommia Bark 5-30 parts, Liquidambar Fruit 3-20 parts, Chaenomeles Root 3-25 parts, Clematis Root 3-20 parts; Among them, the prepared aconite root, processed aconite root, and processed aconite root are all processed products, and the total weight of the prepared aconite root, processed aconite root, and processed aconite root accounts for 1%-8% of the total weight of the active ingredients of the traditional Chinese medicine.

2. The topical traditional Chinese medicine composition according to claim 1, characterized in that, The active components of the traditional Chinese medicine, by weight, include: Frankincense 5-10 parts, Myrrh 5-10 parts, Black aconite 1-3 parts, Fried Atractylodes lancea 6-12 parts, Processed Aconitum carmichaelii 1-3 parts, Processed Aconitum kusnezoffii 1-3 parts, Saposhnikovia divaricata 5-10 parts, Notopterygium incisum 5-10 parts, Angelica pubescens 5-10 parts, Corydalis yanhusuo 6-12 parts, Raw Coix lacryma-jobi 10-20 parts, Trachelospermum jasminoides 8-18 parts, Carthamus tinctorius 3-8 parts, Spatholobus suberectus 10-25 parts, Drynaria fortunei 8-18 parts, Morus alba twigs 10-25 parts, Piper kadsura 8-18 parts, Acanthopanax senticosus 6-15 parts, Taxillus chinensis 10-25 parts, Achyranthes bidentata 6-15 parts, Dipsacus asper 8-18 parts, Raw Eucommia ulmoides 8-18 parts, Liquidambar formosana 5-12 parts, Chaenomeles speciosa 6-15 parts, Clematis chinensis 5-12 parts.

3. The external application traditional Chinese medicine composition for warming the meridians, dispelling cold, strengthening muscles and tendons, and relieving pain according to claim 2, is characterized in that, The active components of the traditional Chinese medicine include the warming and dispelling cold and relieving pain group, the wind-dispelling and dampness-removing group, the blood-activating and meridian-clearing group, and the muscle-strengthening and foundation-consolidating group; The warming and dispersing cold and relieving pain group consists of prepared aconite root, prepared aconite root, black aconite slices, frankincense, myrrh and corydalis rhizome; The wind-dispelling and dampness-removing group consists of stir-fried Atractylodes lancea, Saposhnikovia divaricata, Notopterygium incisum, Angelica pubescens, raw Coix lacryma-jobi, and Clematis chinensis. The blood-activating and meridian-clearing group consists of Trachelospermum jasminoides, Carthamus tinctorius, Spatholobus suberectus, Morus alba twigs, Piper kadsura, Achyranthes bidentata, and Liquidambar formosana. The strengthening and consolidating group consists of Drynaria fortunei, Acanthopanax senticosus, Taxillus chinensis, Dipsacus asper, Eucommia ulmoides, and Chaenomeles speciosa.

4. The external application traditional Chinese medicine composition according to claim 3, wherein the weight ratio of the warming and dispersing cold and relieving pain group, the wind-dispelling and dampness-removing group, the blood-activating and meridian-clearing group, and the muscle-strengthening and foundation-consolidating group is: 1∶1-3∶1.5-4∶1.2-4。 5. The topical traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that, The combined weight of the prepared aconite root, processed aconite root, and processed aconite root accounts for 1.5%-5% of the total weight of the active ingredients of the traditional Chinese medicine.

6. The topical traditional Chinese medicine composition according to any one of claims 1 to 5, characterized in that, The topical Chinese medicine composition also includes a sustained-release carrier, which comprises a composite carrier formed by Artemisia argyi charcoal micropowder, halloysite nanotubes, and hydroxypropyl-cyclodextrin.

7. The topical traditional Chinese medicine composition according to claim 6, characterized in that, The mass ratio of the charcoal micropowder, halloysite nanotubes, and hydroxypropyl-cyclodextrin is 1:0.5-5:1-8.

8. The topical traditional Chinese medicine composition according to any one of claims 1 to 7, characterized in that, The external Chinese medicine composition also includes an external matrix, which includes one or more of the following: hydrogel matrix, ointment matrix, poultice matrix, coating matrix, cream matrix, and powder application matrix; The external Chinese medicine composition is a patch, ointment, gel, poultice, film, powder, hot compress, medicine pack, cream, or external film.

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