An analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine

Abstract

The application discloses a continuous flow microchannel reaction synthesizer for 2-acetylpyrazine, and relates to the technical field of 2-acetylpyrazine reaction analysis, and comprises a support, and a first groove is formed in the side wall of the support. The application can realize multi-directional displacement and multi-angle attitude fine adjustment of the connecting pipeline, can accurately match microchannel reactor modules of different specifications and different arrangement modes, does not need to replace the connecting piece according to the position and inclination angle of the module inlet and outlet, greatly simplifies the multi-module series connection docking process, and improves the connection efficiency. Meanwhile, the fixed disc and the mounting bolt are used for realizing sealed and fastened connection, and the flexible compensation characteristics of the threaded telescopic pipe are used, so that the sealing property of the pipeline docking can be ensured, reaction liquid leakage and gas penetration can be avoided, docking stress can be eliminated, the microchannel reaction system can be continuously and stably operated, and the problems of poor adaptability and complicated docking of the connecting piece in the prior art are solved.

Description

Technical Field

[0001] This invention belongs to the field of 2-acetylpyrazine reaction analysis technology, and particularly relates to an analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine. Background Technology

[0002] In the field of fine chemical intermediate synthesis, the continuous flow microchannel reaction process of 2-acetylpyrazine is gradually replacing the traditional batch synthesis mode due to its advantages of high efficiency, safety and controllability. Online analysis and detection of the reaction process is the core link to achieve intelligent process control.

[0003] Dedicated analytical equipment for the continuous flow microchannel synthesis of 2-acetylpyrazine still suffers from several inherent defects: existing microchannel modules mostly use fixed connectors for docking, which cannot adapt to differences in inlet and outlet positions and tilt angles of microchannel modules of different specifications and arrangements. This requires frequent replacement of adapters, which is not only cumbersome and inefficient, but also prone to leakage and gas ingress due to poor pipeline sealing and stress concentration, directly disrupting the continuity of the reaction. At the same time, existing detection equipment mostly adopts offline sampling mode, which requires interruption of the reaction process for sampling and testing. It cannot capture the real reaction status in real time, and the bubbles and dissolved gases entrained in the reaction liquid will cause serious scattering interference to the spectral sensing detection, greatly reducing the detection accuracy of smart sensors. It is difficult to accurately reflect the reaction progress, product purity, and raw material conversion status, which cannot meet the actual needs of the smart sensor industry for online, accurate, and intelligent detection of microfluidic reactions, thus restricting the intelligent upgrading of the continuous flow synthesis process of 2-acetylpyrazine.

[0004] To address these issues, we propose an analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine. Summary of the Invention

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine includes a support, a first groove formed on the side wall of the support, a connecting component for sealing the openings of multiple microchannel modules fixedly connected to the inner wall of the first groove, and an analytical component for detecting and analyzing the reaction progress of 2-acetylpyrazine during the reaction process on one side of the connecting component.

[0007] Preferably, the connecting assembly includes a first electric slide rail fixedly connected to the inner wall of a first groove, a plurality of first slide plates slidably connected to the side wall of the first electric slide rail, a mounting plate fixedly connected to the side wall of each of the first slide plates, a second electric slide rail fixedly connected to the inner wall of the mounting plate, and a second slide plate slidably connected to the side wall of each of the second electric slide rails.

[0008] Preferably, a first electric telescopic rod is fixedly connected to the side wall of the second slide plate, a U-plate is fixedly connected to the telescopic end of the first electric telescopic rod, a round rod is rotatably connected to the inner wall of the U-plate, a first motor is fixedly connected to the side wall of the U-plate, and the output end of the first motor passes through the side wall of the U-plate and is fixedly connected to one end of the round rod.

[0009] Preferably, a second motor is fixedly connected to the inner wall of the second groove, a first support rod is fixedly connected to the output end of the second motor, a first connecting pipe is fixedly connected to one end of the first support rod, a threaded telescopic pipe is fixedly connected to the side wall of the first connecting pipe, and a second connecting pipe is fixedly connected to one end of the threaded telescopic pipe.

[0010] Preferably, the outer walls of the second connecting pipe and the first connecting pipe are both fixedly connected to a fixing plate. The side wall of the fixing plate is provided with multiple screw holes, and the corresponding screw holes are threaded and rotatably connected with mounting bolts. The side wall of the U plate is fixedly connected to a support rod. One end of the support rod is fixedly connected to a first fixing plate. The inner wall of the first fixing plate is fixedly connected to a third electric slide rail. The side wall of the third electric slide rail is slidably connected to a third sliding plate.

[0011] Preferably, a second fixing plate is fixedly connected to the side wall of the third sliding plate, a fourth electric slide rail is fixedly connected to the inner wall of the second fixing plate, a fourth sliding plate is slidably connected to the side wall of the fourth electric slide rail, and a second electric telescopic rod is fixedly connected to the side wall of the fourth sliding plate.

[0012] Preferably, a fixing block is fixedly connected to the telescopic end of the second electric telescopic rod, a third groove is provided on the side wall of the fixing block, a side rod is rotatably connected to the inner wall of the third groove, a third motor is fixedly connected to the side wall of the fixing block, and the output end of the third motor passes through the side wall of the fixing block and is fixedly connected to one end of the side rod.

[0013] Preferably, the side rod has a fourth groove in its wall, a fourth motor is fixedly connected to the inner wall of the fourth groove, a second support rod is fixedly connected to the output end of the fourth motor, and one end of the second support rod is fixedly connected to the outer wall of the second connecting pipe.

[0014] Preferably, the analysis component includes a detection shell fixedly connected to the bottom side wall of the first connecting tube, the detection shell having a communicating opening on the side wall adjacent to the first connecting tube, and a first solenoid valve being provided inside the corresponding opening, a hydrophobic and breathable membrane being fixedly connected to the inner wall of the detection shell, and an ultraviolet spectrometer being fixedly connected to the top inner wall of the detection shell.

[0015] Preferably, a vacuum pump is fixedly connected to the bottom side wall of the detection shell, the air inlet of the vacuum pump extends inward through the side wall of the detection shell, a through hole is opened in the side wall of the detection shell, and a second solenoid valve is arranged inside the corresponding through hole, the second solenoid valve is located above the hydrophobic and breathable membrane.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0017] This invention, through the coordinated operation of multiple sets of electric slide rails, electric telescopic rods, and drive motors, enables multi-directional displacement and multi-angle attitude fine-tuning of connecting pipelines. It can accurately match microchannel reactor modules of different specifications and arrangements, eliminating the need to individually replace connectors based on the position and tilt angle of the module's inlet and outlet, greatly simplifying the multi-module series docking process and improving connection efficiency. At the same time, relying on the fixed plate and mounting bolts to achieve a sealed and secure connection, combined with the flexible compensation characteristics of the threaded telescopic tube, it can not only ensure the sealing of the pipeline docking, preventing reaction liquid leakage and gas infiltration, but also eliminate docking stress, ensuring the continuous and stable operation of the microchannel reaction system, solving the problems of poor connector compatibility and cumbersome docking in the prior art.

[0018] This invention employs an in-situ sampling and detection mode, directly sampling through the microchannel module connection pipeline without interrupting the reaction process, enabling real-time capture of the actual state of the 2-acetylpyrazine reaction. A vacuum degassing structure is formed by combining a hydrophobic and gas-permeable membrane with a vacuum pump. Utilizing the membrane's gas-permeable but liquid-impermeable characteristic, it efficiently removes bubbles and dissolved gases from the reaction solution, completely eliminating the scattering and interference of bubbles on spectral detection. Combined with intelligent sensing detection by an ultraviolet spectrometer, it can accurately analyze the reaction solution components and accurately determine the reaction progress, product purity, and raw material conversion. Compared to existing offline detection technologies, the detection results are more consistent with actual reaction conditions, significantly improving data reliability and detection accuracy. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0020] Figure 2 This is a partial structural diagram of the present invention. Figure 1 ;

[0021] Figure 3 This is a partial structural diagram of the present invention. Figure 2 ;

[0022] Figure 4 This is a partial structural diagram of the present invention. Figure 3 ;

[0023] Figure 5 For the present invention Figure 4 Enlarged view of part A;

[0024] Figure 6 This is a cross-sectional view of part of the structure of the present invention.

[0025] In the diagram: 1. First groove; 2. Connecting assembly; 21. First electric slide rail; 22. First sliding plate; 23. Mounting plate; 24. Second electric slide rail; 25. Second sliding plate; 26. First electric telescopic rod; 27. U-plate; 28. Round rod; 29. ​​First motor; 210. Second groove; 211. Second motor; 212. First support rod; 213. First connecting pipe; 214. Threaded telescopic pipe; 215. Second connecting pipe; 216. Fixing plate; 217. Mounting bolt; 218. First fixing plate; 219. Third electric slide rail 220. Rail; 221. Third slide plate; 222. Second fixed plate; 223. Fourth electric slide rail; 224. Fourth slide plate; 225. Second electric telescopic rod; 226. Fixed block; 227. Third groove; 228. Side rod; 229. Third motor; 230. Fourth groove; 231. Fourth motor; 232. Second support rod; 233. Support rod; 3. Analysis component; 31. Detection shell; 32. First solenoid valve; 33. Hydrophobic and breathable membrane; 34. Ultraviolet spectrometer; 35. Vacuum pump; 36. Second solenoid valve; 4. Bracket. Detailed Implementation

[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0027] The following electrical components are all electrically connected to the external PLC controller.

[0028] Reference Figure 1 - Figure 6 An analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine includes a support 4, a first groove 1 is provided on the side wall of the support 4, a connecting component 2 for sealing the openings of multiple microchannel modules is fixedly connected to the inner wall of the first groove 1, and an analysis component 3 is provided on one side of the connecting component 2 for detecting and analyzing the reaction progress of 2-acetylpyrazine during the reaction process.

[0029] In this embodiment, the connecting component 2 includes a first electric slide rail 21 fixedly connected to the inner wall of the first groove 1, a plurality of first slide plates 22 slidably connected to the side wall of the first electric slide rail 21, an mounting plate 23 fixedly connected to the side wall of each of the first slide plates 22, a second electric slide rail 24 fixedly connected to the inner wall of the mounting plate 23, and a second slide plate 25 slidably connected to the side wall of each of the second electric slide rails 24.

[0030] The side walls of the second slide plate 25 are all fixedly connected to the first electric telescopic rod 26. The telescopic end of the first electric telescopic rod 26 is fixedly connected to the U plate 27. The inner wall of the U plate 27 is rotatably connected to the round rod 28. The side wall of the U plate 27 is fixedly connected to the first motor 29. The output end of the first motor 29 passes through the side wall of the U plate 27 and is fixedly connected to one end of the round rod 28.

[0031] The rod wall of the round rod 28 has a second groove 210. The inner wall of the second groove 210 is fixedly connected to a second motor 211. The output end of the second motor 211 is fixedly connected to a first support rod 212. One end of the first support rod 212 is fixedly connected to a first connecting pipe 213. The side wall of the first connecting pipe 213 is fixedly connected to a threaded telescopic pipe 214. One end of the threaded telescopic pipe 214 is fixedly connected to a second connecting pipe 215.

[0032] The second connecting pipe 215 and the outer wall of the first connecting pipe 213 are both fixedly connected to a fixing plate 216. The side wall of the fixing plate 216 is provided with multiple screw holes, and the corresponding screw holes are threaded and rotatably connected to mounting bolts 217. The side wall of the U plate 27 is fixedly connected to a support rod 233. One end of the support rod 233 is fixedly connected to a first fixing plate 218. The inner wall of the first fixing plate 218 is fixedly connected to a third electric slide rail 219. The side wall of the third electric slide rail 219 is slidably connected to a third sliding plate 220.

[0033] The side wall of the third slide plate 220 is fixedly connected to the second fixed plate 221, the inner wall of the second fixed plate 221 is fixedly connected to the fourth electric slide rail 222, the side wall of the fourth electric slide rail 222 is slidably connected to the fourth slide plate 223, and the side wall of the fourth slide plate 223 is fixedly connected to the second electric telescopic rod 225.

[0034] The telescopic end of the second electric telescopic rod 225 is fixedly connected to a fixing block 226. A third groove 227 is provided on the side wall of the fixing block 226. A side rod 228 is rotatably connected to the inner wall of the third groove 227. A third motor 229 is fixedly connected to the side wall of the fixing block 226. The output end of the third motor 229 passes through the side wall of the fixing block 226 and is fixedly connected to one end of the side rod 228.

[0035] The side rod 228 has a fourth groove 230 on its wall. A fourth motor 231 is fixedly connected to the inner wall of the fourth groove 230. A second support rod 232 is fixedly connected to the output end of the fourth motor 231. One end of the second support rod 232 is fixedly connected to the outer wall of the second connecting pipe 215.

[0036] Specifically, the first groove 1 provides installation and fixing space for the first electric slide rail 21, ensuring that the connecting component 2 is installed neatly and preventing the outward protrusion of components from interfering with the operation of other mechanisms; the first electric slide rail 21 provides lateral sliding force, driving multiple first slide plates 22 to move along a preset trajectory, realizing the coarse adjustment of the position of the first slide plate 22 and subsequent components; the first slide plate 22 serves as the bearing base of the mounting plate 23, transmitting the sliding force of the first electric slide rail 21, driving the mounting plate 23 to simultaneously realize lateral position adjustment; the mounting plate 23 provides an installation carrier for the second electric slide rail 24, fixing the position of the second electric slide rail 24 and ensuring the operational stability of the second electric slide rail 24; the second electric slide rail 24 provides longitudinal sliding force, driving the second slide plate 25 along a direction perpendicular to the first electric slide rail 21. The displacement enables precise positioning of the second slide plate 25 and subsequent components; the second slide plate 25, as the bearing base of the first electric telescopic rod 26, transmits the sliding force of the second electric slide rail 24, driving the first electric telescopic rod 26 to synchronously achieve longitudinal position adjustment; the first electric telescopic rod 26 provides axial extension and retraction power, driving the U-plate 27 to move closer to or away from the microchannel reactor module, achieving precise adjustment of the docking distance; the U-plate 27 provides a rotational support carrier for the round rod 28, and at the same time provides a mounting base for the first motor 29, constraining the rotational trajectory of the round rod 28 and ensuring rotational coaxiality; the round rod 28, as the connecting base between the first support rod 212 and the second motor 211, transmits the rotational power of the first motor 29, driving the first support rod 212 to achieve circumferential attitude adjustment; the first electric... The machine 29 provides the driving power for the rotation of the circular rod 28, controls the start, stop and rotation angle of the circular rod 28, and realizes the initial calibration of the posture of the first connecting tube 213. The second groove 210 provides an embedded installation space for the second motor 211, avoiding the second motor 211 from protruding outward and causing motion interference, and at the same time fixing the position of the second motor 211. The second motor 211 provides the driving power for the deflection of the first support rod 212, controls the deflection angle of the first support rod 212, and realizes the precise fine adjustment of the orientation of the first connecting tube 213. The first support rod 212 connects the output end of the second motor 211 to the first connecting tube 213, transmits the deflection power of the second motor 211, and drives the first connecting tube 213 to realize orientation adjustment. The first connecting tube 213 serves as the connecting pipeline at the outlet end of the microchannel reactor module. The first connecting pipe 213 and the second connecting pipe 215 are flexibly connected by a threaded telescopic pipe 214, which adaptively compensates for displacement differences during the docking process, ensuring the sealing and stability of the pipeline. The second connecting pipe 215 serves as the connecting pipeline at the inlet end of the microchannel reactor module, transporting the reaction liquid conducted by the first connecting pipe 213 to the next microchannel module, realizing multi-module series connection. The fixed plate 216 increases the contact area between the first connecting pipe 213, the second connecting pipe 215 and the microchannel reactor module, ensuring the sealing of the docking and providing a connection carrier for the mounting bolt 217. The screw hole provides threaded connection space for the mounting bolt 217, constrains the installation position of the mounting bolt 217, and ensures uniform tightening force.The mounting bolt 217 is screwed into the screw hole to achieve a sealed and secure connection between the fixing plate 216 and the microchannel reactor module, preventing leakage of liquid or gas at the pipeline connection point; the support rod 233 supports and fixes the first fixing plate 218, transmits the supporting force of the U-plate 27, and ensures the installation stability of the first fixing plate 218 and the subsequent slide rail mechanism; the first fixing plate 218 provides an installation carrier for the third electric slide rail 219, fixes the position of the third electric slide rail 219, and ensures smooth sliding of the third electric slide rail 219; the third electric slide rail 219 provides lateral sliding force, driving the third slide plate 220 to move, realizing the lateral position adjustment of the second fixing plate 221 and subsequent components; the third slide plate 220 serves as the first The second fixed plate 221 serves as the supporting base, transmitting the sliding force of the third electric slide rail 219, and driving the second fixed plate 221 to simultaneously achieve lateral position adjustment. The second fixed plate 221 provides an installation carrier for the fourth electric slide rail 222, fixing the position of the fourth electric slide rail 222 and ensuring that the fourth electric slide rail 222 operates without deviation. The fourth electric slide rail 222 provides longitudinal sliding force, driving the fourth sliding plate 223 to move, and realizing the longitudinal position adjustment of the second electric telescopic rod 225 and subsequent components. The fourth sliding plate 223, as the supporting base of the second electric telescopic rod 225, transmits the sliding force of the fourth electric slide rail 222, and drives the second electric telescopic rod 225 to simultaneously achieve longitudinal position adjustment. The second electric telescopic rod 225 provides axial telescopic power, driving the fixed block 226 to move closer to or further away from the microchannel reactor module, achieving precise adjustment of the docking distance of the second connecting pipe 215. The fixed block 226 provides a rotational support carrier for the side rod 228 and a mounting base for the third motor 229, constraining the rotation trajectory of the side rod 228. The third groove 227 provides an embedded rotational space for the side rod 228, preventing frictional interference between the side rod 228 and the fixed block 226 during rotation. The side rod 228 serves as the connection base between the second support rod 232 and the fourth motor 231, transmitting the rotational power of the third motor 229, driving the second support rod 232 to achieve circumferential attitude adjustment. 229 provides the driving power for the rotation of the side rod 228, controlling the start, stop, and rotation angle of the side rod 228 to achieve preliminary calibration of the posture of the second connecting tube 215. The fourth groove 230 provides an embedded installation space for the fourth motor 231, avoiding motion interference caused by the outward protrusion of the fourth motor 231, and fixing the position of the fourth motor 231. The fourth motor 231 provides the driving power for the deflection of the second support rod 232, controlling the deflection angle of the second support rod 232 to achieve precise fine-tuning of the orientation of the second connecting tube 215. The second support rod 232 connects the output end of the fourth motor 231 to the second connecting tube 215, transmitting the deflection power of the fourth motor 231 to drive the second connecting tube 215 to achieve orientation adjustment.

[0037] In this embodiment, the analysis component 3 includes a detection shell 31 fixedly connected to the bottom side wall of the first connecting tube 213. The side wall of the detection shell 31 adjacent to the first connecting tube 213 has a communicating opening, and a first solenoid valve 32 is provided inside the corresponding opening. A hydrophobic and breathable membrane 33 is fixedly connected to the inner wall of the detection shell 31, and an ultraviolet spectrometer 34 is fixedly connected to the top inner wall of the detection shell 31.

[0038] A vacuum pump 35 is fixedly connected to the bottom side wall of the detection housing 31. The air inlet of the vacuum pump 35 extends inward through the side wall of the detection housing 31. A through hole is opened on the side wall of the detection housing 31, and a second solenoid valve 36 is installed inside the corresponding through hole. The second solenoid valve 36 is located above the hydrophobic and breathable membrane 33.

[0039] Specifically, the detection shell 31 provides a sealed chamber for the detection of the reaction liquid, and also provides a mounting carrier for the hydrophobic and breathable membrane 33, the ultraviolet spectrometer 34, and the vacuum pump 35, ensuring a sealed and interference-free detection environment. The opening connects the first connecting pipe 213 to the internal chamber of the detection shell 31, enabling the sampling and diversion of the reaction liquid. The first solenoid valve 32 controls the opening and closing of the opening, allowing the reaction liquid to be sampled as needed, and closes after sampling to prevent the main reaction liquid from continuously flowing into the detection shell 31. The hydrophobic and breathable membrane 33 utilizes its gas-permeable but liquid-impermeable properties to separate the gas and liquid in the reaction liquid, providing a separation mechanism for vacuum degassing. The ultraviolet spectrometer 34, as the core component of the intelligent sensor, performs spectral detection on the degassed reaction liquid to analyze the reaction progress and product purity of 2-acetylpyrazine. The vacuum pump 35 extracts gas from the inside of the detection shell 31 to form a negative pressure environment, providing power for the gas-liquid separation of the hydrophobic and breathable membrane 33, and extracting bubbles and dissolved gases from the reaction liquid. The through hole serves as a discharge channel for the reaction liquid after detection, enabling the smooth discharge of detection waste liquid. The second solenoid valve 36 controls the opening and closing of the through hole. It opens after detection to discharge waste liquid and closes during detection to ensure the internal airtightness of the detection shell 31.

[0040] The operating principle of the present invention is described as follows:

[0041] In this invention, before the analyzer is put into use, the support 4 is placed at the adaptation position of the continuous flow microchannel reactor. The support 4 is used to achieve stable support and positioning of the overall mechanism, laying the foundation for subsequent automated docking and testing operations. When the testing operation is started, the first electric slide rail 21 is driven to run, which drives the first slide plate 22 to slide along the preset trajectory, accurately moving the first connecting pipe 213 on the side of the first slide plate 22 to the corresponding position at the outlet of each module of the microchannel reactor, completing the initial positioning. Then the second electric slide rail 24 is started, which drives the second slide plate 25 to perform adaptive sliding. With the extension and retraction of the first electric telescopic rod 26, the U plate 27 and the connected components are driven to move, so that the first connecting pipe 213 is accurately aligned with the outlet end of the corresponding microchannel reactor module, achieving precise alignment before docking.

[0042] After alignment is completed, the first motor 29 is started. The output of the first motor 29 drives the round rod 28 to rotate. During the rotation of the round rod 28, the first support rod 212 and the first connecting tube 213 are simultaneously adjusted in a circumferential manner until the tilt of the first connecting tube 213 is completely matched with the tilt angle of the outlet end of the microchannel reactor module. Then the first motor 29 is turned off to lock the attitude. Then the second motor 211 is started. The output of the second motor 211 drives the first support rod 212 to deflect, further fine-tuning the orientation of the first connecting tube 213 so that the orientation of the port of the first connecting tube 213 is completely matched with the orientation of the outlet end of the microchannel reactor module, ensuring docking sealing and conductivity.

[0043] After the attitude calibration is completed, the first electric slide rail 21 and the second electric slide rail 24 are linked again to drive the first slide plate 22 and the second slide plate 25 to move in coordination. This causes the fixing plate 216 on the outer wall of the first connecting pipe 213 to fit tightly against the side wall of the outlet end of the microchannel reactor module. By screwing the mounting bolt 217 into the corresponding screw hole, a sealed and tight connection is achieved between the fixing plate 216 and the outlet of the microchannel reactor module, ensuring that there is no leakage between the first connecting pipe 213 and the port of the microchannel reactor module. Following the above logic, multiple sets of first connecting pipes 213 are sealed and connected to the outlet ends of the corresponding microchannel reactor modules to ensure the compatibility of simultaneous detection of multiple modules.

[0044] After the first connecting tube 213 is connected, the third motor 229 is started. The output of the third motor 229 drives the side rod 228 to rotate. During the rotation of the side rod 228, the second support rod 232 and the second connecting tube 215 are adjusted in attitude until the tilt of the second connecting tube 215 matches the inlet angle of the microchannel reactor module. Then the third motor 229 is turned off. Subsequently, the fourth motor 231 is started. The output of the fourth motor 231 drives the second support rod 232 to deflect, finely adjusting the orientation of the port of the second connecting tube 215 so that it is consistent with the orientation of the inlet of the microchannel reactor module.

[0045] Then, the third electric slide rail 219 and the fourth electric slide rail 222 are linked to drive the third slide plate 220 and the fourth slide plate 223 to move in coordination. With the extension and retraction of the second electric telescopic rod 225, the side fixing plate 216 of the second connecting pipe 215 is tightly pressed against the side wall of the inlet end of the microchannel reactor module. The second connecting pipe 215 and the inlet end of the microchannel reactor module are sealed and fastened by the mounting bolt 217. The first connecting pipe 213 and the second connecting pipe 215 are flexibly connected by the threaded telescopic pipe 214. The threaded telescopic pipe 214 can adaptively compensate for the docking displacement difference, ensuring that the conduction state of the two is not affected by the adjustment action. Thus, the sealed connection and detection circuit between multiple sets of microchannel reactor modules are completed. There is no need to manually change the connecting parts according to the position and tilt angle of the module port. The docking efficiency is improved by relying on automatic adjustment, ensuring the stability of continuous reaction operation.

[0046] After the detection circuit is completed, 2-acetylpyrazine synthesis raw materials are introduced into the microchannel reactor module. The raw materials flow and react continuously in each module to achieve continuous synthesis of the target product. During the reaction, the first solenoid valve 32 is opened as needed to divert part of the reaction liquid flowing through the first connecting pipe 213 into the detection shell 31. After the sampling amount is reached, the first solenoid valve 32 is closed to achieve micro-scale in-situ sampling and avoid interference with the main reaction process.

[0047] After sampling, the vacuum pump 35 is started and continuously extracts the gas inside the detection shell 31, creating a negative pressure environment inside the detection shell 31. The detection shell 31 is equipped with a hydrophobic and breathable membrane 33. When the reaction liquid flows over the hydrophobic and breathable membrane 33, relying on the property of the hydrophobic and breathable membrane 33 that it is only permeable to air and not to liquid, under the action of negative pressure, the air bubbles, dissolved trace amounts of air and small molecule gases produced by the reaction are extracted by the vacuum pump 35 through the hydrophobic and breathable membrane 33. The reaction liquid remains on the membrane due to surface tension and the hydrophobic property of the membrane, completely eliminating the scattering interference of air bubbles on the detection light path and ensuring detection accuracy.

[0048] After degassing, the ultraviolet spectrometer 34 is activated. Relying on intelligent spectral sensing technology, the 2-acetylpyrazine reaction solution in the detection shell 31 is qualitatively and quantitatively analyzed. The spectral signal of the reaction solution is acquired in real time, and the reaction process, product purity and raw material conversion are analyzed to realize intelligent online monitoring of the reaction process. After a single round of detection is completed, the second solenoid valve 36 is opened to discharge the detected reaction solution from the detection shell 31, emptying the detection chamber and preparing for the next round of in-situ detection, thus realizing cyclic detection and analysis.

[0049] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. An analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine, comprising a support (4), characterized in that, The side wall of the support (4) is provided with a first groove (1), and the inner wall of the first groove (1) is fixedly connected with a connecting component (2) for sealing the openings of multiple microchannel modules. One side of the connecting component (2) is provided with an analysis component (3) for detecting and analyzing the reaction progress of 2-acetylpyrazine during the reaction process.

2. The analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine according to claim 1, characterized in that, The connecting component (2) includes a first electric slide rail (21) fixedly connected to the inner wall of the first groove (1), a plurality of first slide plates (22) slidably connected to the side wall of the first electric slide rail (21), an mounting plate (23) fixedly connected to the side wall of each of the first slide plates (22), a second electric slide rail (24) fixedly connected to the inner wall of the mounting plate (23), and a second slide plate (25) slidably connected to the side wall of each of the second electric slide rails (24).

3. The analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine according to claim 2, characterized in that, The second slide (25) is fixedly connected to the side wall of the first electric telescopic rod (26). The telescopic end of the first electric telescopic rod (26) is fixedly connected to the U plate (27). The inner wall of the U plate (27) is rotatably connected to the round rod (28). The side wall of the U plate (27) is fixedly connected to the first motor (29). The output end of the first motor (29) passes through the side wall of the U plate (27) and is fixedly connected to one end of the round rod (28).

4. The analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine according to claim 3, characterized in that, The rod (28) has a second groove (210) on its wall. A second motor (211) is fixedly connected to the inner wall of the second groove (210). A first support rod (212) is fixedly connected to the output end of the second motor (211). A first connecting pipe (213) is fixedly connected to one end of the first support rod (212). A threaded telescopic pipe (214) is fixedly connected to the side wall of the first connecting pipe (213). A second connecting pipe (215) is fixedly connected to one end of the threaded telescopic pipe (214).

5. The analyzer for the continuous flow microchannel reaction synthesis of 2-acetylpyrazine according to claim 4, characterized in that, The second connecting pipe (215) and the outer wall of the first connecting pipe (213) are both fixedly connected to a fixing plate (216). The side wall of the fixing plate (216) is provided with multiple screw holes, and the corresponding screw holes are threaded and rotatably connected to mounting bolts (217). The side wall of the U plate (27) is fixedly connected to a support rod (233). One end of the support rod (233) is fixedly connected to a first fixing plate (218). The inner wall of the first fixing plate (218) is fixedly connected to a third electric slide rail (219). The side wall of the third electric slide rail (219) is slidably connected to a third sliding plate (220).

6. The analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine according to claim 5, characterized in that, The side wall of the third slide plate (220) is fixedly connected to a second fixed plate (221), the inner wall of the second fixed plate (221) is fixedly connected to a fourth electric slide rail (222), the side wall of the fourth electric slide rail (222) is slidably connected to a fourth slide plate (223), and the side wall of the fourth slide plate (223) is fixedly connected to a second electric telescopic rod (225).

7. The analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine according to claim 6, characterized in that, The telescopic end of the second electric telescopic rod (225) is fixedly connected to a fixing block (226). The side wall of the fixing block (226) is provided with a third groove (227). The inner wall of the third groove (227) is rotatably connected to a side rod (228). The side wall of the fixing block (226) is fixedly connected to a third motor (229). The output end of the third motor (229) passes through the side wall of the fixing block (226) and is fixedly connected to one end of the side rod (228).

8. The analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine according to claim 7, characterized in that, The side rod (228) has a fourth groove (230) on its wall. A fourth motor (231) is fixedly connected to the inner wall of the fourth groove (230). A second support rod (232) is fixedly connected to the output end of the fourth motor (231). One end of the second support rod (232) is fixedly connected to the outer wall of the second connecting pipe (215).

9. The analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine according to claim 4, characterized in that, The analysis component (3) includes a detection shell (31) fixedly connected to the bottom side wall of the first connecting tube (213). The side wall of the detection shell (31) adjacent to the first connecting tube (213) has a communicating opening, and a first solenoid valve (32) is provided inside the corresponding opening. A hydrophobic and breathable membrane (33) is fixedly connected to the inner wall of the detection shell (31), and an ultraviolet spectrometer (34) is fixedly connected to the top inner wall of the detection shell (31).

10. The analyzer for the continuous flow microchannel reactive synthesis of 2-acetylpyrazine according to claim 9, characterized in that, A vacuum pump (35) is fixedly connected to the bottom side wall of the detection shell (31). The air inlet of the vacuum pump (35) extends inward through the side wall of the detection shell (31). A through hole is opened on the side wall of the detection shell (31), and a second solenoid valve (36) is provided inside the corresponding through hole. The second solenoid valve (36) is located above the hydrophobic and breathable membrane (33).

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