A composition for repairing burn and scald wounds and its use and external preparation

Abstract

This invention relates to the field of pharmaceutical technology, and more particularly to a composition for repairing burns and scalds, its application, and a topical medication. The composition of this invention comprises the following components in parts by weight: 2-8 parts of *Phyllanthus yunnanensis* essential oil, 3-10 parts of *Sanguisorba officinalis* extract, 1-5 parts of *Lithospermum erythrorhizon* extract, 1-4 parts of *Bletilla striata* extract, and 0.5-3 parts of *Scutellaria barbata* extract. The composition of this invention, when prepared as a topical medication, can achieve anti-inflammatory and analgesic effects, broad-spectrum antibacterial properties, and promote wound repair, providing a basis for the development of burn and scald medications.

Description

Technical Field

[0001] This invention relates to the field of medical technology, and in particular to a composition for repairing burn wounds and its application as a topical medicine. Background Technology

[0002] Burns and scalds are common types of skin trauma in clinical practice. After the wound is damaged, symptoms such as vasodilation, tissue edema, inflammatory exudation, burning pain, etc. will appear rapidly. Staphylococcus aureus, Pseudomonas aeruginosa, etc. in the environment can easily colonize and infect the wound, causing inflammatory reactions such as suppuration and ulceration.

[0003] Currently, commonly used topical burn preparations in clinical practice mainly include silver sulfadiazine cream and moist burn ointment. However, these preparations have limitations to varying degrees: long-term use of some chemical drugs can easily lead to drug resistance, and their effect on promoting wound healing is limited; while existing traditional Chinese medicine preparations have certain therapeutic effects, they often suffer from problems such as narrow antibacterial spectrum, unsatisfactory anti-inflammatory and analgesic effects, and poor preparation stability.

[0004] Gaultheria leucocarpa var. yunnanensis, a plant belonging to the genus Gaultheria in the family Ericaceae, possesses properties such as clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and dispelling wind and dampness. Modern pharmacological studies have shown that Gaultheria leucocarpa has a wide range of pharmacological effects, including anti-inflammatory, analgesic, antibacterial, and antioxidant properties.

[0005] There are currently no reports on the preparation of Yunnan white pearl into burn wound repair agents using existing technologies. Summary of the Invention

[0006] The purpose of this invention is to provide a composition for repairing burns and scalds, as well as its application and topical medication. The composition of this invention uses Yunnan white pearl essential oil, Sanguisorba officinalis extract, Lithospermum erythrorhizon extract, Bletilla striata extract, and Scutellaria barbata extract as active ingredients to achieve anti-inflammatory, analgesic, broad-spectrum antibacterial, and wound-healing effects.

[0007] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a composition for repairing burn wounds, comprising the following components in parts by weight: 2-8 parts of Yunnan white pearl essential oil, 3-10 parts of Sanguisorba officinalis extract, 1-5 parts of Lithospermum erythrorhizon extract, 1-4 parts of Bletilla striata extract, and 0.5-3 parts of Scutellaria barbata extract.

[0008] Preferably, the components include the following parts by mass: 4-6 parts of Yunnan white pearl essential oil, 5-8 parts of Sanguisorba officinalis extract, 2-4 parts of Lithospermum erythrorhizon extract, 2-3 parts of Bletilla striata extract, and 1.5-2.5 parts of Scutellaria barbata extract.

[0009] Preferably, the components include the following parts by mass: Five parts of Yunnan white pearl essential oil, 6.5 parts of Sanguisorba officinalis extract, 3 parts of Lithospermum erythrorhizon extract, 2.5 parts of Bletilla striata extract, and 2 parts of Scutellaria barbata extract.

[0010] The present invention also provides the use of the composition in the preparation of topical medications for repairing burn and scald wounds.

[0011] Preferably, the dosage form of the topical medication is a cream or a gel.

[0012] This invention also provides a topical cream for repairing burns and scalds, comprising the following components in parts by weight: The composition comprises 10-28 parts petrolatum, 4-8 parts stearic acid, 6-10 parts cetyl alcohol, 3-5 parts glyceryl monostearate, 2-4 parts sodium lauryl sulfate, 0.5-1.5 parts glycerin, 8-12 parts azone, 0.5-1.5 parts ethylparaben, 0.05-0.1 parts water.

[0013] This invention also provides a method for preparing a topical ointment for repairing burns and scalds, comprising the following steps: (1) Weigh each component according to the mass fractions of the topical cream described above; (2) Mix petrolatum, stearic acid, cetyl alcohol and glyceryl monostearate, heat to 70~85℃, stir and melt to obtain the oil phase; (3) Glycerol, sodium dodecyl sulfate and water are mixed to obtain an aqueous phase; (4) Mix the oil phase and water phase, stir for 10-30 minutes, add the composition, azone and ethylparaben, stir evenly to obtain the topical cream.

[0014] This invention also provides a topical gel for repairing burn and scald wounds, comprising the following components in parts by weight: The composition comprises 10-20 parts of a gelling agent, 0.8-1.2 parts of a humectant, 10-20 parts of a preservative, and 60-70 parts of water. The gelling agent is one or more of carbomer, hydroxypropyl methylcellulose, hydroxyethylcellulose, sodium alginate, and poloxamer. The moisturizer is one or more of glycerin, propylene glycol and hyaluronic acid; The preservative is one or more of ethylparaben, sodium benzoate, and potassium sorbate.

[0015] This invention also provides a method for preparing a topical gel for repairing burns and scalds, comprising the following steps: 1) Weigh each component according to the mass fractions of the external gel described above; 2) Mix the gelling agent and water, let it stand and swell for 8-12 hours to obtain the gel matrix; 3) Mix the composition with the gel matrix to obtain a mixture; 4) Mix the mixture with a moisturizer and a preservative to obtain a topical gel.

[0016] The present invention also provides the application of the aforementioned topical cream, the topical cream prepared by the aforementioned preparation method, the topical gel, or the topical gel prepared by the aforementioned preparation method in the preparation of a drug for repairing burn and scald wounds.

[0017] Beneficial effects

[0018] (1) In the composition of the present invention, Bletilla striata has the unique function of forming film, protecting wounds and preventing adhesion. Combined with the fast-acting analgesic and antibacterial properties of Dianbaizhu essential oil, the astringent and wound-healing properties of Sanguisorba officinalis, the anti-scar and regenerating properties of Lithospermum erythrorhizon, and the antibacterial and anti-inflammatory properties of Scutellaria barbata, the effects of each component are complementary and there is no mutual antagonism. It achieves the effects of anti-inflammatory and analgesic, broad-spectrum antibacterial, and promoting wound repair. It can also accelerate wound healing and reduce scar formation.

[0019] (2) The combination of the present invention has a more obvious antibacterial effect than the single component, and is particularly effective in inhibiting Staphylococcus aureus and Pseudomonas aeruginosa, and can effectively prevent and control burn wound infection.

[0020] (3) The compositions of the present invention are all commonly used Chinese medicines with good safety. They are prepared as external preparations to avoid the side effects of oral administration.

[0021] (4) The composition of the present invention is prepared into an ointment and a gel. The ointment has a high oil content and is suitable for wounds with less exudation. The gel has a high water content and good air permeability and is suitable for wounds with more exudation. Detailed Implementation

[0022] In this invention, Yunnan white pearl essential oil has rapid anti-inflammatory and analgesic effects, broad-spectrum antibacterial properties, and quickly controls acute inflammation and pain in wounds; Sanguisorba officinalis exerts astringent and desquamating effects, stops bleeding and promotes wound healing, quickly stopping tissue fluid exudation and laying the foundation for wound healing; Bletilla striata has film-forming and wound-protecting effects, promotes epithelial regeneration, and assists in antibacterial action. Bletilla striata can form a breathable protective film on the wound, preventing secondary infection and adhesion during dressing changes, and accelerating skin epithelial repair; Lithospermum erythrorhizon has long-lasting anti-inflammatory effects and inhibits scar hyperplasia; Scutellaria barbata has heat-clearing and detoxifying, blood-activating and diuretic effects, which can promote local blood circulation in the wound, accelerate the excretion of metabolic waste, assist in improving wound repair efficiency, and reduce the risk of infection. The five herbs combined have heat-clearing and detoxifying, astringent and hemostatic, tissue-regenerating and wound-healing, antibacterial and analgesic effects; the herbs complement each other without antagonistic effects, achieving anti-inflammatory and analgesic effects, broad-spectrum antibacterial effects, and promoting wound repair, accelerating wound healing and reducing scar formation.

[0023] The following detailed description of the solutions provided by the present invention, in conjunction with the embodiments, should not be construed as limiting the scope of protection of the present invention.

[0024] The preparation method of Yunnan white pearl essential oil in this embodiment of the invention includes the following steps: (1) Select fresh branches and leaves of Yunnan white pearl without mold or impurities, wash them with deionized water, drain the water, and then chop them into pieces with a chopper to a particle size of 1.5cm to obtain Yunnan white pearl fragments. (2) Place the crushed Yunnan white pearl into a distillation kettle, add distilled water at a mass ratio of 1:5, and carry out steam distillation. The distillation conditions are: temperature 100℃, time 1.5h, and pressure 0.03MPa. (3) Collect the distillation product and condense it to obtain condensate; let the condensate stand at 25°C for 30 min to separate the layers, and then separate the oil and water. The upper aqueous phase is Yunnan white pearl hydrosol, and the lower oil phase is Yunnan white pearl crude oil. (4) Distill the crude oil of Yunnan white pearl at a temperature of 80℃, a vacuum of 180Pa, a feed rate of 5mL / min, a scraping speed of 160rpm, and a cooling temperature of 8℃ to obtain Yunnan white pearl essential oil.

[0025] The preparation method of Sanguisorba officinalis extract in this embodiment of the invention includes the following steps: The dried Sanguisorba officinalis root was cleaned and purified, then pulverized and passed through a 50-mesh sieve to obtain Sanguisorba officinalis powder. The Sanguisorba officinalis powder was mixed with 70% ethanol at a mass-to-volume ratio of 1g:10mL, and ultrasonically extracted at 50℃ and 300W for 40min to obtain the extract. The extract was centrifuged at 4000rpm for 15min, the supernatant was collected, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 1.25 at 60℃. The extract was then freeze-dried under vacuum to obtain the Sanguisorba officinalis extract.

[0026] The preparation method of the comfrey extract in this embodiment of the invention includes the following steps: The dried Lithospermum root was pulverized and passed through a 60-mesh sieve to obtain Lithospermum powder. The Lithospermum powder was mixed with 75% ethanol at a mass-volume ratio of 1g:9mL and extracted twice at 60℃ in the dark for 1 hour each time. The extracts were combined and concentrated under reduced pressure to a paste with a relative density of 1.3 at 60℃. The paste was then freeze-dried under vacuum to obtain Lithospermum extract.

[0027] The preparation method of Bletilla striata extract in this embodiment of the invention includes the following steps: The dried Bletilla striata tubers were pulverized and passed through a 50-mesh sieve to obtain Bletilla striata powder. The Bletilla striata powder was mixed with 50% ethanol at a mass-to-volume ratio of 1 g:10 mL, and extracted twice by reflux at 60°C for 2 hours each time. The extracts were combined, filtered, and the filtrate was collected. The filtrate was concentrated to 1 / 3 of its original volume at 60°C, and anhydrous ethanol was added to make the alcohol content of the solution reach 70%. The mixture was allowed to stand overnight, and the precipitate was collected, dried, and the Bletilla striata extract was obtained.

[0028] The preparation method of the Scutellaria barbata extract in this embodiment of the invention includes the following steps: The Scutellaria barbata was pulverized and passed through a 50-mesh sieve to obtain Scutellaria barbata powder. The Scutellaria barbata powder was mixed with 70% ethanol at a mass-to-volume ratio of 1 kg:10 L, and extracted twice by reflux at 60°C for 2 hours each time. The extracts were combined, filtered, and the filtrate was concentrated to an extract with a relative density of 1.15 at 60°C. The extract was then freeze-dried under vacuum to obtain the Scutellaria barbata extract.

[0029] The Staphylococcus aureus in the experimental examples of this invention is ATCC 6538; The Pseudomonas aeruginosa in the experimental examples of this invention is ATCC 9027.

[0030] Example 1

[0031] Preparation of topical creams for repairing burn and scald wounds

[0032] Accurately weigh 5 kg of Yunnan white pearl essential oil, 3 kg of Sanguisorba officinalis extract, 5 kg of Lithospermum erythrorhizon extract, 3 kg of Bletilla striata extract, and 2 kg of Scutellaria barbata extract and mix them to obtain the composition.

[0033] Take 5 kg of petrolatum, 8 kg of stearic acid, 4 kg of cetyl alcohol and 3 kg of glyceryl monostearate, heat to 80°C, stir to melt and mix evenly to obtain the oil phase.

[0034] Take 10 kg of glycerol, 1 kg of sodium dodecyl sulfate and 50 kg of purified water and mix them at 80 °C to obtain the aqueous phase.

[0035] At 300 rpm, the aqueous phase was slowly added to the oil phase and stirred for 20 min. When the temperature was lowered to 40°C, the above composition, 1 kg azone and 0.05 kg ethylparaben were added, stirred evenly, and cooled to room temperature to obtain a topical cream.

[0036] Example 2

[0037] Preparation of a topical gel for repairing burn and scald wounds

[0038] Accurately weigh 5 kg of Yunnan white pearl essential oil, 6 kg of Sanguisorba officinalis extract, 3 kg of Lithospermum erythrorhizon extract, 3 kg of Bletilla striata extract and 2 kg of Scutellaria barbata extract, mix them to obtain the composition, and set aside for later use.

[0039] Mix 1 kg of carbomer 940 and 60 kg of purified water, let stand for 10 h to swell, and obtain a gel matrix.

[0040] The composition was added to the gel matrix and homogenized at 8000 rpm for 15 min. Then, 8 kg of glycerin, 5 kg of propylene glycol, and 0.1 kg of ethylparaben were added and mixed evenly to obtain a topical gel.

[0041] Experimental Example 1

[0042] Physicochemical performance testing

[0043] Appearance inspection: The topical cream of Example 1 and the topical gel of Example 2 were taken respectively and observed under natural light. The results are shown in Table 1.

[0044] pH: The pH of the topical cream of Example 1 and the topical gel of Example 2 was measured at 25°C using a pH meter. Ten samples were taken for each sample, and the average value was calculated.

[0045] Particle size distribution: The particle size distribution of the topical cream of Example 1 and the topical gel of Example 2 were observed by microscopy. The results are shown in Table 1. Particles smaller than 180 μm should not be detected.

[0046] Viscosity test: The viscosity of the topical cream of Example 1 and the topical gel of Example 2 at 25°C was measured using a rotational viscometer. The results are shown in Table 1.

[0047] Table 1. Results of Physicochemical Performance Tests

[0048] As shown in Table 1, uniform and delicate creams and transparent gels can be prepared using the compositions of the present invention.

[0049] Experiment Example 2

[0050] Microbial limits

[0051] The number of bacteria and fungi in the topical cream of Example 1 and the topical gel of Example 2 was determined by plate counting. The topical cream of Example 1 and the topical gel of Example 2 were placed at 25°C for 3 months, 6 months, 9 months, and 12 months, and the number of bacteria and fungi was determined by plate counting. The results are shown in Table 2.

[0052] Table 2. Number of microorganisms in topical medications after different storage times.

[0053] Table 2 shows that no bacteria or fungi were detected in the topical cream and gel of the present invention within 6 months. A very small number of bacteria were detected at 9 months, and the number of bacteria increased and fungi also appeared at 12 months. This indicates that the topical cream and gel of the present invention are stable for at least 6 months.

[0054] Experimental Example 3

[0055] Antibacterial test

[0056] Staphylococcus aureus and Pseudomonas aeruginosa were inoculated separately onto TSA agar plates and incubated at 37°C for 20 h. Single colonies were then picked and inoculated onto TSB agar plates and incubated at 37°C with shaking for 20 h. The bacterial concentration was adjusted to 1.0 × 10⁻⁶ with sterile physiological saline. 6 cfu / mL.

[0057] Take a sterile petri dish with a diameter of 90 mm, pour in 20 mL of MHA culture medium, and let it solidify before use. Use a sterile cotton swab to dab the above bacterial solution and spread it evenly on the surface of the MHA plate. Spread it 3 times, rotating the plate 60° each time to ensure even inoculation.

[0058] Take sterile filter paper discs (6 mm in diameter) and immerse them in the topical cream of Example 1, the topical gel of Example 2, the positive control silver sulfadiazine cream, negative control 1 (the blank matrix of Example 1, where the cream was prepared from components other than the composition of Example 1) and negative control 2 (the blank matrix of Example 2, where the gel was prepared from components other than the composition of Example 2) for 30 minutes to obtain drug-containing paper discs. Place the drug-containing paper discs on the surface of MHA plates inoculated with bacterial culture, 4 discs per plate, and prepare 3 parallel plates for each sample. Gently press the paper discs with sterile forceps to ensure close contact with the culture medium.

[0059] The plates were inverted and incubated in a 37℃ incubator for 20 hours. The diameter of the inhibition zone (including the diameter of the filter paper) was measured using calipers. The results are shown in Table 3.

[0060] Table 3 Results of antibacterial test

[0061] A zone with an inhibition zone diameter >6mm has an antibacterial effect.

[0062] Table 3 shows that the topical cream of Example 1 and the topical gel of Example 2 can effectively inhibit Staphylococcus aureus and Pseudomonas aeruginosa.

[0063] Experiment Example 4

[0064] Second-degree burn model in mice

[0065] SPF-grade Kunming mice, half male and half female, 6-8 weeks old, weighing 18-22g (purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd.), were used to establish models in each group of mice before the experiment.

[0066] Hair removal was performed on the backs of mice using an 8% sodium sulfide solution in a 2cm x 2cm area. After hair removal, the area was washed with warm water. The mice were only used for modeling after the skin in the hair-removed area showed no redness, swelling, or breakage. Mice were anesthetized by intraperitoneal injection of a 1% sodium pentobarbital solution at a dose of 50 mg / kg. A circular scalding head (1.5cm in diameter) was heated to 100℃ using a scalding device and applied vertically to the hair-removed skin area on the mouse's back with a constant pressure of 5g for 5 seconds. The burned skin became pale and hardened, exhibiting typical deep second-degree burn characteristics, indicating a successful mouse model.

[0067] Thirty-nine mice that successfully developed the model were randomly divided into six groups: a model control group (n=5), a negative control group 1 (n=5), a negative control group 2 (n=5), a positive control group (n=8), an example group 1 (n=8), and an example group 2 (n=8). Immediately after modeling, each mouse was injected intraperitoneally with 1 mL of 0.9% sodium chloride solution to treat shock.

[0068] Drug administration was performed 2 hours after model establishment. Control mice received no drug. Negative control group 1 mice were given the cream prepared from the components of Example 1 (excluding the composition), negative control group 2 mice were given the gel prepared from the components of Example 2 (excluding the composition), positive control group mice were given silver sulfadiazine cream, Example 1 mice were given the topical cream prepared in Example 1, and Example 2 mice were given the topical gel prepared in Example 2. The drug was evenly applied to the wound surface in each group to a thickness of 2 mm, ensuring complete coverage. Administration was once daily. The wound was cleaned with sterile saline before each administration.

[0069] On days 0, 5, 10, 15 and 20 after the first administration, the wound edges were traced with a transparent film, and the wound area was calculated using ImageJ image analysis software after scanning. The wound healing rate was also calculated.

[0070] Wound healing rate = (wound area on day 0 - current wound area) / wound area on day 0 × 100%. The results are shown in Table 4.

[0071] Table 4 Wound healing rate at different treatment durations

[0072] As shown in Table 4, after 20 days of administration, the healing rate of the wounds in the groups of Examples 1 and 2 of the present invention can reach more than 90%, indicating that the composition of the present invention can effectively treat wounds, and the wounds are almost completely healed after 20 days.

[0073] The time it took for the wounds of each group of mice to completely close without forming a scab or for the scab to fall off naturally was recorded. The results are shown in Table 5.

[0074] Table 5. Wound healing time in mice of different groups

[0075] It is evident that the topical ointment and gel of this invention resulted in complete wound healing within 21 days.

[0076] On days 5 and 15 after drug administration, two mice from each group were taken, and blood was collected by enucleation. Serum was separated, and the levels of TNF-α and IL-6 in the serum were detected by ELISA. The results are shown in Table 6.

[0077] Table 6. Effects of different drugs on serum inflammatory factors

[0078] Table 6 shows that the topical medications of Examples 1 and 2 of this invention have significant anti-inflammatory effects and can effectively inhibit the content of inflammatory factors.

[0079] Application Example 1

[0080] Ms. Sun, 78 years old, suffered severe second-degree burns to her left thigh due to a gas cylinder explosion at home. She applied the topical ointment of Example 1 of this invention three times a day for 28 days, and the wounds healed.

[0081] As can be seen from the above embodiments, the present invention provides a composition for repairing burn and scald wounds, its application, and a topical medication. The composition of the present invention uses Yunnan white pearl essential oil, Sanguisorba officinalis extract, Lithospermum erythrorhizon extract, Bletilla striata extract, and Scutellaria barbata extract as active ingredients. The active ingredients have complementary effects and no antagonistic interactions, achieving anti-inflammatory and analgesic effects, broad-spectrum antibacterial activity, and promoting wound repair, thus accelerating wound healing and reducing scar formation. This provides a basis for the development of burn and scald medications.

[0082] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A composition for repairing burn wounds, characterized in that, The components include the following parts by mass: 2-8 parts of Yunnan white pearl essential oil, 3-10 parts of Sanguisorba officinalis extract, 1-5 parts of Lithospermum erythrorhizon extract, 1-4 parts of Bletilla striata extract, and 0.5-3 parts of Scutellaria barbata extract.

2. The composition according to claim 1, characterized in that, The components include the following parts by mass: 4-6 parts of Yunnan white pearl essential oil, 5-8 parts of Sanguisorba officinalis extract, 2-4 parts of Lithospermum erythrorhizon extract, 2-3 parts of Bletilla striata extract, and 1.5-2.5 parts of Scutellaria barbata extract.

3. The composition according to claim 1, characterized in that, The components include the following parts by mass: Five parts of Yunnan white pearl essential oil, 6.5 parts of Sanguisorba officinalis extract, 3 parts of Lithospermum erythrorhizon extract, 2.5 parts of Bletilla striata extract, and 2 parts of Scutellaria barbata extract.

4. The use of the composition according to any one of claims 1 to 3 in the preparation of a topical medicine for repairing burn and scald wounds.

5. The application according to claim 4, characterized in that, The dosage form of the topical medication is a cream or a gel.

6. A topical ointment for repairing burns and scalds, characterized in that, The components include the following parts by mass: The composition according to any one of claims 1 to 3 comprises 10 to 28 parts of petrolatum, 4 to 8 parts of stearic acid, 6 to 10 parts of cetyl alcohol, 3 to 5 parts of glyceryl monostearate, 2 to 4 parts of sodium lauryl sulfate, 0.5 to 1.5 parts of glycerin, 8 to 12 parts of azone, 0.5 to 1.5 parts of ethylparaben, 0.05 to 0.1 parts of ethylparaben, and 40 to 60 parts of water.

7. A method for preparing a topical ointment for repairing burns and scalds, characterized in that, The steps include the following: (1) Weigh each component according to the mass fractions of the topical cream as described in claim 6; (2) Mix petrolatum, stearic acid, cetyl alcohol and glyceryl monostearate, heat to 70~85℃, stir and melt to obtain the oil phase; (3) Glycerol, sodium dodecyl sulfate and water are mixed to obtain an aqueous phase; (4) Mix the oil phase and water phase, stir for 10-30 minutes, add the composition, azone and ethylparaben, stir evenly to obtain the topical cream.

8. A topical gel for repairing burn and scald wounds, characterized in that, The components include the following parts by mass: The composition according to any one of claims 1 to 3 comprises 10 to 20 parts, gelling agent 0.8 to 1.2 parts, moisturizer 10 to 20 parts, preservative 0.05 to 0.15 parts, and water 60 to 70 parts; The gelling agent is one or more of carbomer, hydroxypropyl methylcellulose, hydroxyethylcellulose, sodium alginate, and poloxamer. The moisturizer is one or more of glycerin, propylene glycol and hyaluronic acid; The preservative is one or more of ethylparaben, sodium benzoate, and potassium sorbate.

9. A method for preparing a topical gel for repairing burn and scald wounds, characterized in that, The steps include the following: 1) Weigh each component according to the mass fractions of the topical gel as described in claim 8; 2) Mix the gelling agent and water, let it stand and swell for 8-12 hours to obtain the gel matrix; 3) Mix the composition with the gel matrix to obtain a mixture; 4) Mix the mixture with a moisturizer and a preservative to obtain a topical gel.

10. The application of the topical cream of claim 6, the topical cream prepared by the preparation method of claim 7, the topical gel of claim 8, or the topical gel prepared by the preparation method of claim 9 in the preparation of a drug for repairing burn and scald wounds.

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