A multi-parameter linkage control method for traditional Chinese medicinal material ultra-high pressure treatment

Abstract

The application discloses a multi-parameter linkage control method for traditional Chinese medicinal material ultrahigh pressure treatment, relates to the technical field of parameter linkage control, and is used for solving the problem that tissue dissociation is insufficient in different batches or different tissue characteristic traditional Chinese medicinal material treatment. Whether the traditional Chinese medicinal material enters an effective compression response state is judged based on cavity pressure change in the initial stage of traditional Chinese medicinal material ultrahigh pressure treatment, and a tissue evaluation mechanism is triggered. In a response period, a volume rebound amount is obtained through controlled pressure relief, a compression rebound index is calculated, an elastic attenuation weight is generated in combination with pressure holding time, a tissue dissociation state is comprehensively evaluated, and comparison is made with a target dissociation interval, and a continuous pressure increasing or stage switching strategy is selected. After stage switching, component dissolution amount feedback is introduced, the target dissociation interval is adaptively adjusted, and a treatment termination condition is determined in combination with impurity content, so that the effective component dissolution rate is improved, and the non-target impurity content is significantly reduced.

Description

Technical Field

[0001] This invention relates to the field of parameter linkage control technology, and more specifically, to a multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials. Background Technology

[0002] Ultra-high pressure processing technology, as a typical physical intensification method, has been widely used in the structural modification and component release processes of food, agricultural products and plant raw materials. In the industrial pre-processing of Chinese medicinal materials, ultra-high pressure processing is usually used to destroy cell wall structure, promote the dissolution of effective components and shorten the time of subsequent extraction processes. It is especially suitable for Chinese medicinal materials with high fiber content and dense tissue.

[0003] The existing technology has the following shortcomings:

[0004] Currently, existing technologies mainly employ a control method combining preset pressure plateau values ​​and fixed holding times to regulate the ultra-high pressure treatment process. This lacks a real-time sensing and quantitative assessment mechanism for the tissue compression response and structural dissociation state of medicinal materials under ultra-high pressure. Consequently, it cannot dynamically adjust pressurization, holding, and depressurization strategies based on changes in the tissue state of the medicinal materials. This leads to insufficient tissue dissociation or excessive damage in the treatment of different batches or with different tissue characteristics, resulting in unstable dissolution of effective components and increased content of non-target impurities. Therefore, a multi-parameter linkage control method for ultra-high pressure treatment of medicinal materials is proposed.

[0005] The information disclosed in the background section is only intended to enhance the understanding of the background of this disclosure, and therefore may include information that does not constitute prior art known to those skilled in the art. Summary of the Invention

[0006] To overcome the aforementioned deficiencies of the prior art, embodiments of the present invention provide a multi-parameter linkage control method for ultra-high pressure processing of Chinese medicinal materials. This method addresses the problems mentioned in the background art by employing a tissue response triggering mechanism based on changes in chamber pressure, a tissue elasticity quantification model based on volume rebound during the depressurization stage, and an adaptive adjustment strategy for the target dissociation interval based on component dissolution feedback.

[0007] To achieve the above objectives, the present invention provides the following technical solution: a multi-parameter linkage control method for ultra-high pressure treatment of traditional Chinese medicinal materials, comprising the following steps:

[0008] Step S1: Before subjecting the Chinese medicinal materials to ultra-high pressure treatment, monitor the cavity pressure, analyze the compression response state of the Chinese medicinal materials based on the cavity pressure, and determine whether the tissue evaluation mechanism is triggered. After triggering the tissue evaluation mechanism, set the response period.

[0009] Step S2: Perform a depressurization operation on the pressure equipment within the response cycle, detect the volume rebound of the Chinese medicinal materials and generate the compression rebound index, access the control database to retrieve the holding time and target dissociation interval, and calculate the elastic decay weight based on the holding time.

[0010] Step S3: Evaluate the tissue dissociation state of Chinese medicinal materials by comprehensively considering the compression rebound index and elastic decay weight. Combine the target dissociation range to select either a continuous pressurization strategy or a phase switching strategy. When the phase switching strategy is executed, collect the dissolution amount of Chinese medicinal materials.

[0011] Step S4: Adjust the target dissociation range using the component dissolution rate, conduct a second evaluation of the tissue dissociation state based on the adjusted target dissociation range, detect the impurity content of the Chinese medicinal materials, and determine whether to stop the current ultra-high pressure treatment based on the evaluation results.

[0012] In a preferred embodiment, in step S1, a pressure device is used to apply controlled external pressure to the Chinese medicinal materials, i.e., ultra-high pressure treatment, in order to change the internal tissue structure of the Chinese medicinal materials.

[0013] Pressure equipment is a compression device used to process Chinese medicinal herbs under ultra-high pressure.

[0014] Before performing ultra-high pressure treatment on Chinese medicinal materials, the real-time pressure status inside the treatment chamber is continuously monitored to obtain the chamber pressure.

[0015] The cavity pressure at adjacent sampling times is differentially calculated to obtain the cavity pressure change rate.

[0016] In a preferred embodiment, in step S1, when the rate of change of cavity pressure is less than a preset response trigger pressure threshold, the Chinese medicinal materials are determined to be in an initial loose state.

[0017] When the rate of change of cavity pressure is greater than or equal to the preset response trigger pressure threshold, it is determined that the Chinese medicinal material has entered the compression response state from the initial loose state.

[0018] Upon detecting that the Chinese medicinal materials have entered a compression response state, the tissue assessment mechanism is triggered;

[0019] In the organizational evaluation mechanism, a response period is set, which is used to limit the time window for collecting and calculating subsequent organizational response parameters.

[0020] In a preferred embodiment, in step S2, after triggering the tissue assessment mechanism and entering the response cycle, a controlled depressurization operation is performed on the pressure equipment within the response cycle.

[0021] The depressurization operation involves reducing the pressure in the processing chamber while maintaining a controlled depressurization path and rate, so that the Chinese medicinal materials transition from a pressurized state to a low-pressure state.

[0022] During the depressurization operation, the volume rebound of the Chinese medicinal materials is obtained by detecting the return flow of the medium in the hydraulic system during the depressurization phase.

[0023] After obtaining the volume rebound, the corresponding volume compression is further obtained. The volume compression is the volume change of the Chinese medicinal material relative to its initial state during the pressurization stage.

[0024] Divide the volumetric rebound by the volumetric compression to obtain the compression rebound index.

[0025] In a preferred embodiment, in step S2, the access control database is accessed to retrieve the holding time and target dissociation interval corresponding to the current processing batch.

[0026] The pressure holding time is the cumulative duration for which the pressure equipment maintains a constant cavity pressure under the target pressure platform;

[0027] The target dissociation range is a pre-defined target range for tissue dissociation states;

[0028] A control database refers to a data storage unit connected to the control system of pressure equipment;

[0029] The elastic decay weight is obtained by performing a monotonic mapping operation on the holding time using a normalization function.

[0030] In a preferred embodiment, in step S3, the ratio of elastic decay weight to compression rebound index is taken as the tissue dissociation state and compared with the target dissociation interval:

[0031] If the tissue dissociation state is less than the lower limit of the target dissociation interval, the tissue dissociation degree is determined to be insufficient.

[0032] If the dissociation state of the organization is greater than or equal to the lower limit of the target dissociation interval and less than or equal to the upper limit of the target dissociation interval, then the degree of dissociation of the organization is determined to be effective dissociation.

[0033] If the dissociation state of the organization is greater than the upper limit of the target dissociation interval, the degree of dissociation of the organization is determined to be excessive dissociation;

[0034] When the current degree of tissue dissociation of Chinese medicinal materials is insufficient, a continuous pressure strategy is selected.

[0035] When the current tissue dissociation degree of Chinese medicinal materials is either effective dissociation or excessive dissociation, the execution phase switching strategy should be selected.

[0036] In a preferred embodiment, in step S3, when selecting a stage switching strategy, a dissolution collection cycle is preset, and the target components of the Chinese medicinal materials are obtained by accessing the Chinese medicinal material component configuration library.

[0037] The components of the extract formed during the ultra-high pressure treatment were detected by an ultraviolet-visible spectroscopy detection device to obtain the concentration data of the target components in the extract. At the same time, the outflow volume data of the target components in the extract was obtained by a flow meter.

[0038] The concentration data of the target component in the extract and the volume data of the extract are multiplied together to obtain the dissolution amount of the component of the Chinese medicinal material.

[0039] In a preferred embodiment, in step S4, the historical database is accessed to obtain the historical component dissolution benchmark corresponding to the current Chinese medicinal material variety and target component, and the ratio of component dissolution amount to component dissolution benchmark is used as the component dissolution achievement coefficient.

[0040] The ratio of the component dissolution achievement coefficient to the preset component dissolution achievement threshold is used as the dissociation interval adjustment coefficient, and the interval shift offset is calculated using the dissociation interval adjustment coefficient.

[0041] When the dissociation interval adjustment coefficient is less than 1, the interval translation offset is added to the upper and lower limits of the current target dissociation interval to obtain the adjusted upper and lower limits, and then combined to form the adjusted target dissociation interval.

[0042] When the dissociation interval adjustment coefficient is equal to 1, the target dissociation interval remains unchanged;

[0043] When the dissociation interval adjustment coefficient is greater than 1, the upper and lower limits of the current target dissociation interval are subtracted by the interval translation offset to obtain the adjusted upper and lower limits, which are then combined to form the adjusted target dissociation interval.

[0044] In a preferred embodiment, in step S4, the tissue dissociation state of the Chinese medicinal material is compared with the adjusted target dissociation range, and the current tissue dissociation state of the Chinese medicinal material is evaluated a second time to obtain the current tissue dissociation degree of the Chinese medicinal material.

[0045] When the degree of organizational dissociation is effective dissociation, the secondary assessment is judged to be in a state of dissociation coordination.

[0046] When the degree of tissue dissociation is insufficient, the secondary assessment determines that dissociation has not been achieved.

[0047] When the degree of tissue dissociation is excessive dissociation, the secondary assessment determines it to be a state of dissociation imbalance.

[0048] When the secondary evaluation result is in a state of dissociation coordination or dissociation imbalance, the detection operation of the impurity content of Chinese medicinal materials is triggered. The optical scattering signal of the Chinese medicinal material extract is obtained by an online turbidimeter, and the impurity content is extracted based on the optical scattering signal.

[0049] In a preferred embodiment, in step S4, when the secondary evaluation result is a dissociation and coordination state and the impurity content is greater than the preset impurity control threshold, it is determined to trigger the termination of the current ultra-high pressure processing.

[0050] When the secondary evaluation result is a state of dissociation imbalance, further judgment is made based on the impurity content: if the impurity content is greater than the preset impurity control threshold, the ultra-high pressure processing is stopped; otherwise, the subsequent control loop is entered, and the process trigger of step S1 is called to re-trigger the organization evaluation mechanism.

[0051] The technical effects and advantages of this invention are as follows:

[0052] This invention determines whether Chinese medicinal materials have entered an effective compression response state based on changes in chamber pressure during the initial stage of ultra-high pressure treatment, triggering a tissue assessment mechanism. Within the response period, controlled depressurization is used to obtain volume rebound, calculating the compression rebound index and generating an elastic decay weight based on the holding time. Further, the tissue dissociation state is comprehensively assessed and compared with the target dissociation range, selecting either continuous pressurization or a phased switching strategy. After phase switching, feedback on component dissolution is introduced to adaptively adjust the target dissociation range, and the treatment termination condition is determined based on impurity content. Through this multi-parameter linkage and phased control, the dissolution rate of effective components is improved while significantly reducing the content of non-target impurities, achieving a shift from experience-based control to precise structural state regulation in ultra-high pressure treatment. Attached Figure Description

[0053] Figure 1 This is a flowchart illustrating the implementation of a multi-parameter linkage control method for ultra-high pressure processing of Chinese medicinal materials according to the present invention.

[0054] Figure 2 This is a schematic diagram illustrating the steps of a multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials according to the present invention. Detailed Implementation

[0055] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0056] This invention determines whether Chinese medicinal materials have entered an effective compression response state based on changes in chamber pressure during the initial stage of ultra-high pressure treatment, triggering a tissue assessment mechanism. Within the response period, controlled depressurization is used to obtain volume rebound, calculating the compression rebound index and generating an elastic decay weight based on the holding time. Further, the tissue dissociation state is comprehensively assessed and compared with the target dissociation range. A strategy of continuous pressurization or phase switching is selected. After phase switching, component dissolution feedback is introduced to adaptively adjust the target dissociation range, and the treatment termination condition is determined based on impurity content. Through this multi-parameter linkage and phased control, the dissolution rate of effective components is improved while significantly reducing the content of non-target impurities.

[0057] Example 1, such as Figures 1 to 2 As shown, a multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials includes the following steps:

[0058] Step S1: Before subjecting the Chinese medicinal materials to ultra-high pressure treatment, monitor the cavity pressure, analyze the compression response state of the Chinese medicinal materials based on the cavity pressure, and determine whether the tissue evaluation mechanism is triggered. After triggering the tissue evaluation mechanism, set the response period.

[0059] Step S2: Perform a depressurization operation on the pressure equipment within the response cycle, detect the volume rebound of the Chinese medicinal materials and generate the compression rebound index, access the control database to retrieve the holding time and target dissociation interval, and calculate the elastic decay weight based on the holding time.

[0060] Step S3: Evaluate the tissue dissociation state of Chinese medicinal materials by comprehensively considering the compression rebound index and elastic decay weight. Combine the target dissociation range to select either a continuous pressurization strategy or a phase switching strategy. When the phase switching strategy is executed, collect the dissolution amount of Chinese medicinal materials.

[0061] Step S4: Adjust the target dissociation range using the component dissolution rate, conduct a second evaluation of the tissue dissociation state based on the adjusted target dissociation range, detect the impurity content of the Chinese medicinal materials, and determine whether to stop the current ultra-high pressure treatment based on the evaluation results.

[0062] The specific implementation is as follows:

[0063] In step S1, during the modern processing of Chinese medicinal materials, a pressure device is used to apply controlled external pressure to the Chinese medicinal materials, namely ultra-high pressure treatment, in order to change the internal tissue structure of the Chinese medicinal materials, thereby achieving the processing objectives such as sterilization, penetration promotion, tissue dissociation, or optimization of component release conditions.

[0064] Pressure equipment is a compression device used to process Chinese medicinal materials under ultra-high pressure. It can establish and maintain a controllable pressure environment higher than normal pressure within a sealed processing chamber.

[0065] Before performing ultra-high pressure treatment on Chinese medicinal materials, the real-time pressure status within the treatment chamber is continuously monitored to obtain the chamber pressure. The chamber pressure originates from pressure sensors installed on the pressure inlet pipeline of the treatment chamber, reflecting the actual pressure exerted on the Chinese medicinal materials by the medium within the chamber per unit time, and characterizing the initiation of a pressure response in the tissue of the Chinese medicinal materials.

[0066] It should be noted that a pressure sensor is a pressure detection device installed on the pressure inlet pipeline of the processing chamber, which is used to collect the instantaneous pressure value of the pressure transmission medium at the pipeline and the inlet of the chamber in real time.

[0067] During the continuous increase of cavity pressure, the compression response state of the Chinese medicinal materials is analyzed based on the changing trend of cavity pressure. Specifically, the cavity pressure at adjacent sampling times is differentially calculated to obtain the cavity pressure change rate. The cavity pressure change rate is used to characterize the transient intensity of the pressure loading process. The larger the value, the stronger the compressive driving force acting on the Chinese medicinal material tissue per unit time, and the higher the rate of deformation of the internal tissue structure of the Chinese medicinal material; the smaller the value, the more gradual the pressure loading process, and the internal tissue of the Chinese medicinal material is mainly in a state of slow compression or has not yet formed an effective structural response.

[0068] Compare the rate of change of chamber pressure with the preset response trigger pressure threshold:

[0069] When the rate of change of cavity pressure is less than the preset response trigger pressure threshold, it indicates that the pressure loading rate is insufficient to induce significant deformation of the internal structure of the Chinese medicinal material. The volume change of the Chinese medicinal material mainly comes from the compaction of the loading gap, the filling of the medium, or the adjustment of the material position. An effective compression response that can be used to characterize the mechanical properties of the tissue has not yet been formed, and the Chinese medicinal material is judged to be in an initial loose state.

[0070] When the rate of change of cavity pressure is greater than or equal to the preset response trigger pressure threshold, it indicates that the pressure loading rate has reached or exceeded the critical condition for the response of the Chinese medicinal material's tissue structure. It is determined that the Chinese medicinal material has entered the compression response state from the initial loose state. At this time, the internal cell walls, fibrous skeletons and other structures of the Chinese medicinal material begin to participate in the pressure bearing process, and its deformation behavior has the significance of tissue structure characterization.

[0071] It should be noted that the response trigger pressure threshold is a pressure value preset according to the type of Chinese medicinal material and the loading conditions. It is used to distinguish between the state in which Chinese medicinal materials only undergo medium filling or position adjustment in the low-pressure stage and the state in which they begin to produce real tissue compression and structural response in the higher-pressure stage. Specifically, based on historical test data of the same type of Chinese medicinal materials at different pressure loading rates, the range of cavity pressure change rate corresponding to the transition of Chinese medicinal materials from the loose compaction stage to the real tissue compression stage is statistically analyzed, and a representative critical value is selected within this range as the response trigger pressure threshold.

[0072] After detecting that the Chinese medicinal materials have entered the compression response state, the tissue evaluation mechanism is triggered. In the tissue evaluation mechanism, a response period is set, which is used to limit the time window for the collection and calculation of subsequent tissue response parameters.

[0073] Through the above method, step S1 realizes the identification of the compression response state of Chinese medicinal materials based on the change of cavity pressure in the early stage of high pressure treatment, and promptly triggers the tissue evaluation mechanism and establishes a unified response cycle when the tissue of Chinese medicinal materials begins to generate an effective compressive response, so as to provide a consistent data basis for the quantitative evaluation of the tissue structure state in the future.

[0074] In step S2, after triggering the tissue evaluation mechanism and entering the response cycle, a controlled depressurization operation is performed on the pressure equipment during the response cycle to obtain the volume rebound behavior of the Chinese medicinal materials during the depressurization process.

[0075] The depressurization operation involves reducing the pressure within the processing chamber while maintaining a controlled depressurization path and rate, thereby transitioning the medicinal materials from a pressurized state to a low-pressure state and inducing an elastic recovery response in their internal structure.

[0076] During the depressurization operation, information on the volume change of Chinese medicinal materials is collected to obtain the volume rebound amount of the Chinese medicinal materials. The volume rebound amount comes from the equivalent volume change data of the pressure transmission medium in the hydraulic system of the pressure equipment, which is specifically obtained by detecting the medium return flow of the hydraulic system during the depressurization stage.

[0077] Volume rebound is used to characterize the ability of Chinese medicinal materials to rebound from a state of compressive deformation to their original structural state under pressure release conditions. The larger the value, the higher the degree of elastic recovery of the internal tissue structure of the Chinese medicinal material and the lower the degree of pressure damage to the cell and fiber structure. The smaller the value, the more obvious the elasticity of the internal tissue structure of the Chinese medicinal material has been significantly reduced, and the tissue structure is difficult to recover after being compressed.

[0078] After obtaining the volume rebound, the corresponding volume compression is further obtained. The volume compression is the volume change of the Chinese medicinal material relative to its initial state during the pressurization stage, which is also calculated from the equivalent volume change data of the pressure transmission medium in the hydraulic system.

[0079] Dividing the volumetric rebound by the volumetric compression yields the compression rebound index, which reflects the degree of elasticity retention of the tissue structure of Chinese medicinal materials after undergoing the processes of pressurization and depressurization. The value ranges from 0 to 1. The closer the value is to 1, the more intact the elasticity of the tissue structure of Chinese medicinal materials is; the closer the value is to 0, the more obvious the elasticity decay of the tissue structure of Chinese medicinal materials is, and the higher the degree of irreversible deformation of the cell wall and fibrous skeleton.

[0080] After generating the compression rebound index, access the control database to retrieve the holding time and target dissociation interval corresponding to the current processing batch.

[0081] The holding time is the cumulative time that the pressure equipment maintains a constant cavity pressure under the target pressure platform. It is used to reflect the intensity of the continuous pressure on Chinese medicinal materials in a high-pressure environment. The larger the value, the longer the continuous action that the tissue structure of the Chinese medicinal materials endures under high pressure.

[0082] The target dissociation range is a pre-defined target range of tissue dissociation state, used to limit the degree of tissue dissociation that is expected to be achieved in the subsequent processing or extraction of Chinese medicinal materials.

[0083] It should be noted that the control database refers to the data storage unit connected to the pressure equipment control system, used to store and manage control parameters, process configuration parameters, and historical processing data related to the ultra-high pressure treatment of Chinese medicinal materials; the target pressure platform refers to the stable pressure range established and maintained by the pressure equipment during the ultra-high pressure treatment of Chinese medicinal materials, corresponding to the predetermined pressure level required for effective treatment of the Chinese medicinal materials. Under the target pressure platform, the cavity pressure within the treatment chamber is controlled within the allowable fluctuation range and remains basically constant to ensure that the Chinese medicinal materials are continuously pressurized under the required pressure conditions.

[0084] Based on the retrieved holding time, the elastic decay weight is further calculated. The elastic decay weight is used to characterize the degree of influence of holding time on the elastic decay of Chinese medicinal materials. The calculation method is to use a normalization function to perform a monotonic mapping operation on the holding time, so that the elastic decay weight increases with the increase of holding time.

[0085] The larger the value of the elastic decay weight, the stronger the cumulative effect of the holding time on the elastic decay of the Chinese medicinal material tissue, and the higher its weight in the subsequent determination of the tissue dissociation state.

[0086] Through the above process, step S2 obtains the volume rebound behavior of Chinese medicinal materials through controlled decompression within a unified response period, constructs a compression rebound index, and generates an elastic decay weight by combining the holding time, thereby providing a quantifiable and comparable key parameter basis for the comprehensive determination of the subsequent tissue dissociation state.

[0087] In step S3, the ratio of elastic decay weight to compression rebound index is taken as the tissue dissociation state, reflecting the degree of tissue dissociation progress of Chinese medicinal materials under the combined influence of the cumulative effect of pressure holding time and pressure relief rebound capacity.

[0088] The larger the compression rebound index, the smaller the tissue dissociation state, indicating that Chinese medicinal materials still maintain a strong volume rebound ability after decompression, have strong tissue structure reversibility, and a low degree of dissociation.

[0089] The greater the elastic decay weight, the greater the tissue dissociation state, indicating that the cumulative decay effect of holding time is stronger, the tissue elastic decay is more obvious, and the degree of dissociation is higher.

[0090] Furthermore, the tissue dissociation state is compared with the target dissociation interval. If the tissue dissociation state is less than the lower limit of the target dissociation interval, the current tissue dissociation degree of the Chinese medicinal material is determined to be insufficient.

[0091] If the tissue dissociation state is greater than or equal to the lower limit of the target dissociation interval and less than or equal to the upper limit of the target dissociation interval, then the current tissue dissociation degree of the Chinese medicinal material is determined to be effective dissociation.

[0092] If the tissue dissociation state is greater than the upper limit of the target dissociation interval, the current tissue dissociation degree of the Chinese medicinal material is determined to be excessive dissociation;

[0093] Based on the current degree of tissue dissociation of the Chinese medicinal materials, either a continuous pressure strategy or a phase switching strategy will be implemented. Specifically:

[0094] When the current degree of tissue dissociation of Chinese medicinal materials is insufficient, a continuous pressure strategy is selected.

[0095] When the current tissue dissociation degree of Chinese medicinal materials is effective dissociation or excessive dissociation, select the execution phase switching strategy;

[0096] Among them, the continuous pressurization strategy refers to calling the set of continuous pressurization parameters pre-configured and stored in the control database to continue to apply control actions to promote dissociation in the ultra-high pressure processing process; the stage switching strategy refers to switching the processing target from continuing to promote dissociation to maintaining stability and suppressing excessive damage, calling the pre-set and stored stage switching strategy parameters, and constraining and managing the tissue dissociation process by reducing the pressure regulation intensity or limiting the pressure disturbance range.

[0097] When the continuous pressurization strategy is selected, the feedback collection of component dissolution is not triggered. After the strategy is completed, the tissue dissociation status is reassessed to determine whether to continue the continuous pressurization strategy or switch to the stage switching strategy.

[0098] When selecting the stage switching strategy, the dissolution collection cycle is preset, and the target components of Chinese medicinal materials are obtained by accessing the Chinese medicinal material component configuration library. The target components refer to the types of effective components required in the extraction process of Chinese medicinal materials.

[0099] The UV-Vis spectroscopy detection device retrieves the absorption wavelength range corresponding to the target component from the component wavelength database, and performs component detection on the extract formed during the ultra-high pressure treatment based on the absorption wavelength range to obtain the concentration data of the target component in the extract.

[0100] At the same time, the flow meter is used to obtain the outflow volume data of the target component in the extract;

[0101] The concentration data of the target component in the extract and the volume data of the extract are multiplied together to obtain the dissolution amount of the component of the Chinese medicinal material.

[0102] It should be noted that the preset dissolution collection cycle can be set according to the diffusion characteristics of the target component in the extraction medium and the extraction process cycle; the Chinese medicinal material component configuration library is used to store the target component information corresponding to different Chinese medicinal materials; the component wavelength database is used to store the characteristic absorption wavelength range corresponding to different components of Chinese medicinal materials; the ultraviolet-visible spectroscopy detection device is an online component detection device that performs spectral detection of the extract based on the light absorption characteristics of the target component within a specific wavelength range.

[0103] In step S4, the historical database is accessed to obtain the historical component dissolution benchmark corresponding to the current Chinese medicinal material variety and target component. The historical component dissolution benchmark is the statistical result of the dissolution amount of the target component that achieved effective extraction in the historical treatment.

[0104] The ratio of the component dissolution amount to the component dissolution benchmark is used as the component dissolution achievement coefficient. The larger the value, the closer the release of the target component is to or exceeds the historical effective extraction level. The smaller the value, the more room there is for improvement in the current tissue dissociation state to promote component release.

[0105] Furthermore, the ratio of the component dissolution achievement coefficient to the preset component dissolution achievement threshold is used as the dissociation interval adjustment coefficient. The absolute value of the difference between the dissociation interval adjustment coefficient and 1 is calculated and multiplied by the interval width of the target dissociation interval to obtain the interval translation offset.

[0106] The target dissociation interval is corrected using the dissociation interval adjustment coefficient. Specifically, when the dissociation interval adjustment coefficient is less than 1, the release degree of the target component is insufficient. The interval shift offset is added to the lower limit of the current target dissociation interval to obtain the adjusted lower limit of the interval. The interval shift offset is added to the upper limit of the current target dissociation interval to obtain the adjusted upper limit of the interval. The adjusted lower limit of the interval and the adjusted upper limit of the interval constitute the adjusted target dissociation interval.

[0107] When the dissociation interval adjustment coefficient is equal to 1, the target dissociation interval remains unchanged;

[0108] When the dissociation interval adjustment coefficient is greater than 1, it indicates that the release of the target component has reached or exceeded the target requirements. Subtract the interval shift offset from the current target dissociation interval lower limit to obtain the adjusted interval lower limit. Subtract the interval shift offset from the current target dissociation interval upper limit to obtain the adjusted interval upper limit. The adjusted interval lower limit and the adjusted interval upper limit constitute the adjusted target dissociation interval.

[0109] The tissue dissociation state of the Chinese medicinal materials is compared with the adjusted target dissociation range to conduct a secondary evaluation of the current tissue dissociation state, thereby obtaining the current degree of tissue dissociation of the Chinese medicinal materials. Specifically:

[0110] When the current degree of tissue dissociation of Chinese medicinal materials is effective dissociation, the secondary assessment is judged to be in a state of coordinated dissociation, indicating that the ultra-high pressure treatment process is in a controllable and effective dissociation stage;

[0111] If the current degree of tissue dissociation of Chinese medicinal materials is insufficient, then the secondary assessment is judged to be in a state of incomplete dissociation, indicating that the target components have not been fully released;

[0112] When the current degree of tissue dissociation of Chinese medicinal materials is excessive dissociation, the secondary assessment will determine that the dissociation is unbalanced, indicating the possibility of excessive damage to the tissue structure and increased risk of impurities.

[0113] When the secondary evaluation result is a state of dissociation coordination or dissociation imbalance, the detection operation of the impurity content of Chinese medicinal materials is further triggered to judge the quality risks that may arise during the ultra-high pressure treatment process.

[0114] The impurity content of Chinese medicinal materials reflects the degree of release of non-target components introduced by the destruction of the tissue structure of Chinese medicinal materials;

[0115] Optical scattering signals corresponding to insoluble solids in the extract of Chinese medicinal materials are obtained by an online turbidimeter. Turbidity mapping curves matching insoluble solids are retrieved from the calibration parameter library. The optical scattering signals are processed based on the turbidimetric mapping curves, and the scattering components corresponding to insoluble solids are extracted. The product of the scattering components and the preset volume correction factor is taken as the impurity content of the Chinese medicinal materials.

[0116] Among them, the solution processing refers to the baseline correction and proportional inversion calculation of the optical scattering signal after inputting the turbidity mapping coefficient into the turbidity inversion unit. The turbidity inversion unit is a functional module used to receive the optical scattering signal and the turbidity mapping coefficient, and to perform signal correction according to the preset conversion rules.

[0117] When the secondary evaluation result is in a dissociation and coordination state, and the impurity content is greater than the preset impurity control threshold, it is determined to trigger the termination of the current ultra-high pressure treatment to avoid the decline in the quality of Chinese medicinal materials due to continued treatment.

[0118] When the secondary evaluation result is a state of dissociation imbalance, further judgment is made based on the impurity content: if the impurity content is greater than the preset impurity control threshold, the ultra-high pressure processing is stopped; otherwise, the subsequent control loop is entered, and the process trigger of step S1 is called to re-trigger the organization evaluation mechanism.

[0119] It should be noted that the historical database is a data unit used to store parameters such as the dissolution rate of components in previous batches of Chinese medicinal materials; the preset component dissolution threshold can be set according to the process requirements of the target component or the statistical results of historical batch data; the calibration parameter library is a parameter library used to store turbidity-content mapping coefficients; the preset volume correction factor can be set according to the optical path length of the sensor; the online turbidimeter is a real-time detection device based on the principle of light scattering; and the preset impurity control threshold can be set according to the impurity tolerance range of the subsequent extraction process.

[0120] Finally, it should be noted that in this paper, relational terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0121] Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0122] In this document, the singular forms “a,” “an,” and “the” may also include the plural forms unless the context clearly indicates otherwise. It should also be understood that terms such as “comprising / including” or “having” specify the presence of the stated features, integrals, steps, operations, components, parts, or combinations thereof, but do not preclude the possibility of the presence or addition of one or more other features, integrals, steps, operations, components, parts, or combinations thereof. Meanwhile, the term “and / or” as used in this specification includes any and all combinations of the associated listed items.

[0123] The various embodiments in this specification are described in a progressive manner. Each embodiment focuses on the differences from other embodiments. The various embodiments can be combined as needed, and the same or similar parts can be referred to each other.

[0124] The above description of the disclosed embodiments will enable those skilled in the art to make or use various modifications to these embodiments. It will be readily apparent to those skilled in the art that the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials, characterized in that: Includes the following steps: Step S1: Before subjecting the Chinese medicinal materials to ultra-high pressure treatment, monitor the cavity pressure, analyze the compression response state of the Chinese medicinal materials based on the cavity pressure, and determine whether the tissue evaluation mechanism is triggered. After triggering the tissue evaluation mechanism, set the response period. Step S2: Perform a depressurization operation on the pressure equipment within the response cycle, detect the volume rebound of the Chinese medicinal materials and generate the compression rebound index, access the control database to retrieve the holding time and target dissociation interval, and calculate the elastic decay weight based on the holding time. Step S3: Evaluate the tissue dissociation state of Chinese medicinal materials by comprehensively considering the compression rebound index and elastic decay weight. Select either a continuous pressurization strategy or a phase switching strategy based on the target dissociation range. When the phase switching strategy is executed, collect the dissolution amount of components from the Chinese medicinal materials. Step S4: Adjust the target dissociation range using the component dissolution rate, conduct a second evaluation of the tissue dissociation state based on the adjusted target dissociation range, detect the impurity content of the Chinese medicinal materials, and determine whether to stop the current ultra-high pressure treatment based on the evaluation results.

2. The multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials according to claim 1, characterized in that: In step S1, a pressure device is used to apply controlled external pressure to the Chinese medicinal materials, i.e., ultra-high pressure treatment, in order to change the internal tissue structure of the Chinese medicinal materials. Pressure equipment is a compression device used to process Chinese medicinal herbs under ultra-high pressure. Before performing ultra-high pressure treatment on Chinese medicinal materials, the real-time pressure status inside the treatment chamber is continuously monitored to obtain the chamber pressure. The cavity pressure at adjacent sampling times is differentially calculated to obtain the cavity pressure change rate.

3. The multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials according to claim 2, characterized in that: In step S1, when the rate of change of cavity pressure is less than the preset response trigger pressure threshold, the Chinese medicinal materials are determined to be in an initial loose state. When the rate of change of cavity pressure is greater than or equal to the preset response trigger pressure threshold, it is determined that the Chinese medicinal material has entered the compression response state from the initial loose state. Upon detecting that the Chinese medicinal materials have entered a compression response state, the tissue assessment mechanism is triggered; In the organizational evaluation mechanism, a response period is set, which is used to limit the time window for collecting and calculating subsequent organizational response parameters.

4. The multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials according to claim 1, characterized in that: In step S2, after the organization assessment mechanism is triggered and the response cycle is entered, a controlled depressurization operation is performed on the pressure equipment within the response cycle. The depressurization operation involves reducing the pressure in the processing chamber while maintaining a controlled depressurization path and rate, so that the Chinese medicinal materials transition from a pressurized state to a low-pressure state. During the depressurization operation, the volume rebound of the Chinese medicinal materials is obtained by detecting the return flow of the medium in the hydraulic system during the depressurization phase. After obtaining the volume rebound, the corresponding volume compression is further obtained. The volume compression is the volume change of the Chinese medicinal material relative to its initial state during the pressurization stage. Divide the volumetric rebound by the volumetric compression to obtain the compression rebound index.

5. A multi-parameter linkage control method for ultra-high pressure treatment of traditional Chinese medicinal materials according to claim 1, characterized in that: In step S2, the access control database is used to retrieve the holding time and target dissociation interval corresponding to the current processing batch; The pressure holding time is the cumulative duration for which the pressure equipment maintains a constant cavity pressure under the target pressure platform; The target dissociation range is a pre-defined target range for tissue dissociation states; A control database refers to a data storage unit connected to the control system of pressure equipment; The elastic decay weight is obtained by performing a monotonic mapping operation on the holding time using a normalization function.

6. A multi-parameter linkage control method for ultra-high pressure treatment of traditional Chinese medicinal materials according to claim 5, characterized in that: In step S3, the ratio of elastic decay weight to compression rebound index is taken as the tissue dissociation state and compared with the target dissociation interval: If the tissue dissociation state is less than the lower limit of the target dissociation interval, the tissue dissociation degree is determined to be insufficient. If the dissociation state of the organization is greater than or equal to the lower limit of the target dissociation interval and less than or equal to the upper limit of the target dissociation interval, then the degree of dissociation of the organization is determined to be effective dissociation. If the dissociation state of the organization is greater than the upper limit of the target dissociation interval, the degree of dissociation of the organization is determined to be excessive dissociation; When the current degree of tissue dissociation of Chinese medicinal materials is insufficient, a continuous pressure strategy is selected. When the current tissue dissociation degree of Chinese medicinal materials is either effective dissociation or excessive dissociation, the execution phase switching strategy should be selected.

7. The multi-parameter linkage control method for ultra-high pressure treatment of Chinese medicinal materials according to claim 1, characterized in that: In step S3, when selecting a stage switching strategy, a dissolution collection cycle is preset, and the target components of the Chinese medicinal materials are obtained by accessing the Chinese medicinal material component configuration library. The components of the extract formed during the ultra-high pressure treatment were detected by an ultraviolet-visible spectroscopy detection device to obtain the concentration data of the target components in the extract. At the same time, the outflow volume data of the target components in the extract was obtained by a flow meter. The concentration data of the target component in the extract and the volume data of the extract are multiplied together to obtain the dissolution amount of the component of the Chinese medicinal material.

8. A multi-parameter linkage control method for ultra-high pressure treatment of traditional Chinese medicinal materials according to claim 1, characterized in that: In step S4, the historical database is accessed to obtain the historical component dissolution benchmark corresponding to the current Chinese medicinal material variety and target component, and the ratio of component dissolution amount to component dissolution benchmark is used as the component dissolution achievement coefficient. The ratio of the component dissolution achievement coefficient to the preset component dissolution achievement threshold is used as the dissociation interval adjustment coefficient, and the interval shift offset is calculated using the dissociation interval adjustment coefficient. When the dissociation interval adjustment coefficient is less than 1, the interval translation offset is added to the upper and lower limits of the current target dissociation interval to obtain the adjusted upper and lower limits, and then combined to form the adjusted target dissociation interval. When the dissociation interval adjustment coefficient is equal to 1, the target dissociation interval remains unchanged; When the dissociation interval adjustment coefficient is greater than 1, the upper and lower limits of the current target dissociation interval are subtracted by the interval translation offset to obtain the adjusted upper and lower limits, which are then combined to form the adjusted target dissociation interval.

9. A multi-parameter linkage control method for ultra-high pressure treatment of traditional Chinese medicinal materials according to claim 6, characterized in that: In step S4, the tissue dissociation state of the Chinese medicinal material is compared with the adjusted target dissociation range, and a second evaluation is performed on the current tissue dissociation state of the Chinese medicinal material to obtain the current tissue dissociation degree of the Chinese medicinal material. When the degree of organizational dissociation is effective dissociation, the secondary assessment is judged to be in a state of dissociation coordination. When the degree of tissue dissociation is insufficient, the secondary assessment determines that dissociation has not been achieved. When the degree of tissue dissociation is excessive dissociation, the secondary assessment determines it to be a state of dissociation imbalance. When the secondary evaluation result is in a state of dissociation coordination or dissociation imbalance, the detection operation of the impurity content of Chinese medicinal materials is triggered. The optical scattering signal of the Chinese medicinal material extract is obtained by an online turbidimeter, and the impurity content is extracted based on the optical scattering signal.

10. A multi-parameter linkage control method for ultra-high pressure treatment of traditional Chinese medicinal materials according to claim 9, characterized in that: In step S4, when the secondary evaluation result is in a dissociation and coordination state and the impurity content is greater than the preset impurity control threshold, it is determined to trigger the termination of the current ultra-high pressure processing. When the secondary evaluation result is a state of dissociation imbalance, further judgment is made based on the impurity content: if the impurity content is greater than the preset impurity control threshold, the ultra-high pressure processing is stopped. Conversely, if the condition is not met, the subsequent control loop will be entered, and the process trigger of step S1 will be invoked to re-trigger the organizational evaluation mechanism.

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