Compositions containing inorganic uv filters and nitrogen-containing compounds

Abstract

This invention relates to a cosmetic composition for skin and / or lips, comprising, in a physiologically acceptable medium, at least: (i) a nitrogen-containing compound of formula (I), wherein *(aa) represents a single or double bond; *R 1 and R 3 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl); *R 2 and R 4 Each is independently selected from H, oxo group, thio group, and NR. x R y C1-C, alkyl, halogen or optionally substituted 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl); *R x and R y Each can independently represent H or C1-C6 alkyl; *R 5 and R 6 Each C1-C group is independently selected from H, oxo, thio, or optionally substituted. 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl), or *R 5 and R 6 (ii) together with the carbon atoms to which they are bonded, they form optionally substituted aryl or optionally substituted imidazolyl groups, and one or more inorganic UV filters.

Description

Technical Field

[0001] This invention relates to the field of cosmetic compositions for use as care and / or cosmetic keratin materials, the cosmetic compositions comprising inorganic UV filters. Background Technology

[0002] It is known that daily exposure to ultraviolet (UV) radiation, even for short periods under normal conditions, can lead to irregular browning and / or pigmentation of the skin (e.g., age spots, uneven skin tone), as well as degradation of collagen and elastin fibers, thereby altering the skin's micro-texture and causing signs of aging (e.g., wrinkles).

[0003] Daily application of sunscreen is essential for preventing sunburn and protecting the skin from UVA / UVB rays. Therefore, numerous compositions for skin photoprotection (UV-A and / or UV-B) have been developed to date, comprising water-soluble and / or lipid-soluble organic UV filters and / or inorganic UV filters capable of selectively absorbing UV radiation. These filters (and their amounts) are selected, in particular, based on the desired Sun Protection Factor (SPF), defined as the ratio between the amount of energy required to produce minimal erythema on sunscreen-protected skin and the amount of energy required to produce the same level of erythema on unprotected skin. Choosing a sunscreen with an appropriate SPF also helps optimize the aesthetics and duration of a tan.

[0004] However, inorganic UV filters, especially titanium dioxide and zinc oxide, often cause a white cast in formulations or on the skin. In the case of cosmetic compositions, this white cast can also affect the darkest shades; it becomes difficult to maintain a high SPF while avoiding a white cast to achieve the desired shade. In the case of sunscreen products, it is also difficult to obtain high SPF products that do not leave a white layer on the skin upon application, and this white layer can persist, which is generally unsightly and therefore disliked by users.

[0005] Therefore, there is still a need to develop new cosmetic products that provide good protection through the presence of inorganic UV filters, but the composition (especially for cosmetic products) or the film applied to the skin (especially for skincare products) does not have a whitening effect.

[0006] The applicant has precisely developed a composition that meets these expectations. It has been unexpectedly demonstrated that the use of nitrogen-containing compounds of formula (I), particularly guanine, can enhance the protective effect provided by inorganic UV filters (also known as the "SPF enhancer" effect) and thus reduce the content of inorganic UV filters, thereby reducing whitening of compositions or films applied to the skin.

[0007] The nitrogen-containing compounds of formula (I), especially guanine, differ from conventional organic compounds used in sunscreen compositions in that they are insoluble.

[0008] According to the present invention, "insoluble compound" refers to a compound in particulate form that is insoluble in water, ethanol or any proportion of water / ethanol mixture at a concentration of 0.5% by weight at room temperature (25°C).

[0009] Although its particulate and insoluble form may provide covering power, the compositions obtained according to the present invention have perfectly acceptable covering power without masking or whitening effects.

[0010] Furthermore, unlike conventional organic compounds used in sunscreen compositions that are known to cause a sticky feeling, nitrogen-containing compounds of formula (I), particularly guanine, provide a pleasant skin feel when applied to keratinous materials.

[0011] Therefore, the combination according to the invention can yield a sunscreen composition containing mineral sunscreen agents and having a very good SPF, with acceptable coverage and good sensory properties even without soluble sunscreen agents, and the formulation or film applied to the skin does not have a mask-like effect or whitening effect. Summary of the Invention

[0012] Therefore, the present invention particularly relates to a cosmetic composition for skin and / or lips, comprising at least: (i) Nitrogen-containing compounds of formula (I) , in Indicates a single bond or a double bond. R 1 and R 3 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl), R 2 and R 4 Each is independently selected from H, oxo group, thio group, and NR. x R y Halogenated or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). R x and R y Independently representing H or C1-C6 alkyl, R 5 and R 6 Each is independently selected from H, oxo group, thio group, or optionally substituted C1-C group. 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). or R 5 and R 6 Together with the carbon atoms they are bonded to, they form optionally substituted aryl or optionally substituted imidazolyl groups, and (ii) One or more inorganic UV filters.

[0013] Preferably, the nitrogen-containing compound of formula (I), preferably guanine, accounts for 0.5% to 20% by weight of the total weight of the composition.

[0014] According to a particular and preferred embodiment, the composition of the present invention comprises only a nitrogen-containing compound of formula (I) and an inorganic UV filter as a sunscreen agent; in other words, it does not contain any other sunscreen agents, let alone soluble sunscreen agents.

[0015] Therefore, using nitrogen-containing compounds of formula (I), such as guanine, in combination with inorganic UV filters can reduce the amount of inorganic UV filters in the formulation while maintaining a comparable SPF. Furthermore, since guanine is less white than titanium dioxide or zinc oxide, its presence causes less whitening to the formulation or skin. Finally, unlike conventional inorganic UV filters, guanine appears to be readily biodegradable and does not bioaccumulate, resulting in a smaller environmental impact.

[0016] Therefore, the combination of compounds of formula (I) according to the invention (e.g., guanine) with inorganic UV filters can provide good sun protection without impairing the coloring and / or covering properties of the composition, the coloring and / or covering properties of which are related to the whitening effect of the inorganic UV filters: the combination according to the invention can achieve all shade ranges in foundation, including dark shades, and can achieve acceptable coverage for care products and sunscreens, while the formulation or film applied to the skin has no whitening effect.

[0017] According to a particular implementation, the nitrogen-containing compound of formula (I) is guanine.

[0018] The present invention also relates to a non-therapeutic cosmetic method for caring for and / or beautifying the skin and / or lips, comprising applying a composition as defined in the present invention to said skin and / or lips.

[0019] Another subject of the present invention is the use of a nitrogen-containing compound (preferably guanine) of formula (I) as defined in the present invention as an enhancer in a composition comprising one or more inorganic UV filters for protecting keratinous materials from UV radiation and / or reducing whitening of the composition containing the inorganic UV filter and / or whitening of the skin when the composition is applied.

[0020] The present invention also relates to a composition comprising a nitrogen-containing compound of formula (I) as defined according to the present invention and one or more inorganic UV filters, for use in preventing and / or treating the harmful effects of ultraviolet radiation on the skin and / or lips. Detailed Implementation

[0021] Therefore, a first object of the present invention is a cosmetic composition for skin and / or lips, which contains at least [amount missing] in a physiologically acceptable medium. (i) Nitrogen-containing compounds of formula (I) , in Indicates a single bond or a double bond; R 1 and R 3 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). R 2 and R 4 Each is independently selected from H, oxo group, thio group, and NR. x R y Halogenated or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). R x and R y Independently representing H or C1-C6 alkyl, R 5 and R 6 Each is independently selected from H, oxo group, thio group, or optionally substituted C1-C group. 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). or R 5 and R 6Together with the carbon atoms they are bonded to, they form optionally substituted aryl or optionally substituted imidazolyl groups, and (ii) One or more inorganic UV filters.

[0022] "Cosmetic composition" means any composition intended for cosmetic purposes, i.e., for aesthetic purposes, which may come into contact with parts of the human body, more particularly with keratinous materials, especially human skin and / or lips.

[0023] "Physiologically acceptable medium" means any excipient suitable for topical application that is non-toxic, non-compatible, unstable and / or poses no risk of allergic reaction when in contact with keratin materials.

[0024] According to the invention, "keratinous material" means skin and / or its appendages, more particularly human skin and / or lips. Specifically, this refers to the skin of the face and / or neck and / or body, as well as the lips. In the context of this invention, keratinous material is healthy, i.e., does not exhibit symptoms or diseases belonging to a pathological state (an "unhealthy" subject suffering from a pathological condition). The terms healthy skin and / or lips or skin and / or lips will be used interchangeably throughout the remainder of the specification.

[0025] Nitrogen-containing compounds of formula (I) Therefore, the compositions according to the invention comprise at least one nitrogen-containing compound of formula (I). , in Indicates a single bond or a double bond. R 1 and R 3 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). R 2 and R 4 Each is independently selected from H, oxo group, thio group, and NR. x R y Halogenated or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). R x and R y Independently representing H or C1-C6 alkyl, R 5 and R 6Each is independently selected from H, oxo group, thio group, or optionally substituted C1-C group. 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl). or R 5 and R 6 Together with the carbon atoms they are bonded to, they form optionally substituted aryl or optionally substituted imidazolyl groups.

[0026] It should be understood that in the compounds of formula (I), This indicates a single or double bond, making each atom in the ring neutral. In other words, the oxidation state of each nitrogen atom in the ring is 3, and the oxidation state of each carbon atom in the ring is 4.

[0027] In some implementation schemes, R 1 and R 3 They are either absent or selected from H and C1-C6 alkyl groups, especially alkyl groups.

[0028] In some implementation schemes, R 2 and R 4 Each is independently selected from H, oxo group, thio group, and NR. x R y And C1-C6 alkyl groups, especially alkyl groups. Preferably, R 2 and R 4 Each group is independently selected from H, oxo, thio, and NH2. Typically, R... 2 and R 4 At least one of them represents an oxo group or a thio group. Preferably, R 4 It indicates an oxo group or a thio group, especially an oxo group.

[0029] In some implementation schemes, R 5 and R 6 Each is independently selected from H, oxo groups and C1-C6 alkyl groups, especially methyl.

[0030] In other implementation schemes, R 5 and R 6 Together with the carbon atoms to which they are bonded, they form optionally substituted aryl groups, especially optionally substituted phenyl groups, or optionally substituted imidazolyl groups. Preferably, the aryl group (especially phenyl) or imidazolium is optionally substituted with one or more substituents, preferably with one or two substituents selected from C1-C6 alkyl, OH, and O-C1-C6 alkyl (e.g., methoxy) groups.

[0031] According to a particular and preferred embodiment, the composition of the present invention comprises a compound of formula (I) corresponding to formula (IA): , in, R 7 Selected from H, C1-C6 alkyl, oxo, OH, thio, SH and O-C1-C6 alkyl. and R 1 To R 4 As mentioned above, and R 8 and R 9 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl).

[0032] R 7 Especially selected from H and oxo groups.

[0033] Preferably, in (IA), R 1 and R 3 Independently does not exist or represents H, R 2 Selected from H, oxo group and NH2, R 4 It is an oxygen group, R 7 Selected from H and oxo groups.

[0034] In one particular embodiment, the compound of formula (I) is selected from: , , , .

[0035] According to a preferred embodiment, the composition of the present invention comprises a compound selected from compounds of formula (I) of formula (IA): , Xanthine, hypoxanthine, uric acid and guanine are preferred, with guanine being more preferred.

[0036] Preferably, in the compound of formula (IA), R 1 It does not exist, R 2 R is an NH2 group. 3 For H and R 4 It is an oxo group. In this embodiment, the compound of formula (I) corresponds to guanine of the following formula: .

[0037] Within the meaning of this invention, "[Cx -C y "Aliphatic chain" should be understood to mean a saturated, straight-chain or branched monovalent hydrocarbon chain containing x to y, especially 1 to 12 carbon atoms. According to the present invention, aliphatic chain encompasses straight-chain or branched substituted or unsubstituted alkyl, alkenyl or alkynyl groups.

[0038] Within the meaning of this invention, "(C x -C y "alkyl" should be understood to mean a monovalent hydrocarbon chain containing x to y, preferably x to y, saturated, straight or branched carbon atoms. Examples include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl or hexyl.

[0039] Within the meaning of this invention, "(C x -C y "Alkenyl" should be understood to mean a monovalent straight-chain or branched hydrocarbon chain containing at least one double bond and x to y carbon atoms, where x is greater than or equal to 2. Examples include vinyl, propenyl, allyl, butenyl, pentenyl, or hexenyl.

[0040] Within the meaning of this invention, "(C x -C y "Alynyl" should be understood to mean a monovalent straight-chain or branched hydrocarbon chain containing at least one triple bond and x to y carbon atoms, where x is greater than or equal to 2. Examples include ethynyl, propynyl, butynyl, pentynyl, or hexynyl.

[0041] Within the meaning of this invention, "halogen atom" or "halogen" should be understood to mean fluorine, chlorine, bromine, and iodine atoms.

[0042] Within the meaning of this invention, "aryl" should be understood to mean an aromatic hydrocarbon group, preferably containing 6 to 10 carbon atoms, and comprising one or more connecting rings, such as phenyl or naphthyl. Advantageously, it is phenyl.

[0043] Within the meaning of this invention, "heteroaryl" or "heteroaryl" should be understood to mean an aromatic group comprising 5 to 10 ring atoms (including one or more heteroatoms, advantageously 1 to 4, or even more advantageously 1 or 2), such as sulfur, nitrogen, or oxygen atoms, and the other ring atoms being carbon atoms. Examples of heteroaryl groups are furanyl, thiophene, pyrrole, pyridinyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, oxadiazolyl, thiazolyl, pyridazinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, quinoxalinyl, or indoleyl.

[0044] Within the meaning of this invention, "optionally substituted" should be understood to mean that the group is optionally substituted by one or more substituents (preferably 1 to 4, especially 1 or 2), said substituents being selected from halogen atoms, C1-C6 alkyl, OH, oxo, aryl, N3, CN, NO2, aralkyl, NR a R b COR c CO2R d CONR e R f and OR g , where R a To R g Independently representing H, C1-C6 alkyl, C1-C6 haloalkyl, or aryl, preferably H or C1-C6 alkyl. Preferably, the substituent is selected from C1-C6 alkyl, oxo, or NR. a R b .

[0045] According to a particular implementation, the nitrogen-containing compound of formula (I) is insoluble.

[0046] According to the present invention, "insoluble compound" refers to a compound in particulate form that is insoluble in water, ethanol or any proportion of water / ethanol mixture at a concentration of 0.5% by weight at room temperature (25°C).

[0047] Although its particulate and insoluble form may provide covering power, the compositions obtained according to the present invention have perfectly acceptable covering power without masking or whitening effects.

[0048] According to a particular embodiment, the compound of formula (Ia) is guanine. .

[0049] Guanine (Cl 75170) is typically in the form of a white to pale yellow powder. It has a refractive index close to 1.8, lower than that of titanium dioxide (TiO2) (2.2) and zinc oxide (ZnO) (2.0), and thus can reduce the opacity and whitening effect produced by the inorganic UV filters associated with it in the compositions of this invention.

[0050] Therefore, the applicant demonstrates in the following embodiments that a comparable level of SPF protection can be maintained by halving the required amount of TiO2 and replacing it with a material having a much lower refractive index. Furthermore, guanine is a biodegradable material with a smaller environmental impact.

[0051] In the composition of the present invention, the content of the nitrogen-containing compound (preferably guanine) of formula (I) is particularly 0.5% to 20% by weight, particularly 1% to 10% by weight, and preferably 5% to 10% by weight relative to the total weight of the composition.

[0052] Therefore, for care compositions, especially care compositions for sun protection, the content of nitrogen-containing compounds (especially guanine) of formula (I) is generally 1% to 20% by weight relative to the total weight of the composition, especially 1% to 10% by weight, preferably 5% to 10% by weight.

[0053] Therefore, for cosmetic compositions, especially foundation compositions, the content of nitrogen-containing compounds (especially guanine) of formula (I) is generally 0.5% to 10% by weight, especially 1% to 5% by weight, relative to the total weight of the composition.

[0054] The compositions of the present invention also contain one or more inorganic UV filters.

[0055] Inorganic UV filters The inorganic UV filter used in this invention is a metal oxide pigment.

[0056] In particular, the inorganic UV filter of the present invention is a metal oxide particle with an average primary particle size of less than or equal to 0.5 μm, more preferably between 0.1 and 0.5 μm, even more preferably between 0.1 and 0.3 μm, or even 0.1 to 0.2 μm.

[0057] They are particularly selected from oxides of titanium, zinc, iron, zirconium and cerium or mixtures thereof.

[0058] According to a particular embodiment of the present invention, the inorganic UV filter is selected from zinc oxide, titanium dioxide, and mixtures thereof.

[0059] According to a particular and preferred embodiment, the composition of the present invention comprises at least titanium dioxide.

[0060] Preferably, the titanium dioxide and zinc oxide particles used in this invention are not nanoparticles, i.e., they are not substances as defined in Article 3 of Regulation 1907 / 2006 (CE), i.e., intentionally manufactured at the nanoscale, containing particles in unbound or aggregated or agglomerated form, wherein in the quantity size distribution, the smallest proportion of particles (50%) has one or more external dimensions between 1 nm and 100 nm.

[0061] Titanium dioxide (Ti02) Titanium dioxide is usually in rutile form.

[0062] It may or may not have undergone surface treatment.

[0063] According to a particular embodiment, titanium dioxide will be surface treated with stearic acid, and preferably with alumina and stearic acid.

[0064] It can be in powder or dispersion form.

[0065] Powdered forms particularly include the Solaveil SpeXtra titanium dioxide powder series from CRODA, especially Solaveil. TM XTP-1, with the INCI name of Titanium Dioxide (and) Stearic Acid (and) Alumina, has an average particle size of 179 nm, with over 99% of the particles smaller than 300 nm and less than 5% smaller than 100 nm. Therefore, it is not nanoparticle TiO2. Particle size was measured using Brookhaven X-ray disc centrifuge (XRDC) technology to measure dispersion on C 12 -C 14 Particle size distribution of SolaveyilSpeXtra powder in alkyl benzoate.

[0066] In another embodiment, a dispersion of TiO2 particles in an oily dispersant is used.

[0067] Examples include, in particular, Solaveyil SpeXtra TM The dispersion product line, especially the following reference products: - Solaveil TM XT-100, its INCI name is Titanium Dioxide (and) C12-C15 Alkyl Benzoate (and) Polyhydroxystearic Acid (and) Stearic Acid (and) Alumina (TiO2 content: approximately 47%). - Solaveil TMXT-300, its INCI name is Titanium Dioxide (and) Caprylic / Capric Triglyceride (and) Polyhydroxystearic Acid (and) Stearic Acid (and) Alumina (TiO2 content: approximately 47%). - Solaveil TM XT-40W, its INCI name is titanium dioxide (and) water (and) polyglycerol-2-decanoate (and) sucrose stearate (and) jojoba ( Simmondsia Chinensis (TiO2 content: approximately 42%).

[0068] According to a particular and preferred embodiment, TiO2 in powder form treated with a lipophilic agent, such as Solaveyil, is used. TM XTP-1, whose INCI name is Titanium Dioxide (and) Stearic Acid (and) Alumina.

[0069] The TiO2 content in the composition of the present invention is typically 1% to 10% by weight relative to the total weight of the composition.

[0070] Zinc oxide (ZnO) Zinc oxide particles are usually in the form of a white powder.

[0071] Average particle size One can especially mention the commercially available Zinc Oxide Gold Seal B from UNIVAR.

[0072] The ZnO content in the composition of the present invention is typically 1% to 10% by weight relative to the total weight of the composition.

[0073] Dispersants Metal oxide particles, particularly TiO2 and / or ZnO, are dispersed in a dispersant and / or wetting agent and ground, for example, using a three-roll mill.

[0074] Dispersants and / or wetting agents particularly include fatty acids such as stearic acid or hydroxystearic acid, fatty acid triglycerides such as caprylic / capric triglycerides, polyglycerol esters of fatty acids such as polyglycerol-3 polyricinoleate, and mixtures thereof.

[0075] Examples include, in particular, the Applecare PDS-300 MB from DKSH, whose INCI name is Polyhydroxystearic acid (and) Caprylic / Capric Triglyceride (and) Isostearic acid (and) Lecithin (and) Polyglycerol-3 Polyricinoleate.

[0076] According to a particular embodiment, the composition of the present invention comprises at least one compound of formula (I) (particularly guanine) and titanium dioxide as an inorganic UV filter.

[0077] According to another particular embodiment, the composition of the present invention comprises at least one compound of formula (I) (particularly guanine) and zinc oxide as an inorganic UV filter.

[0078] According to another particular and preferred embodiment, the composition of the present invention comprises at least one compound of formula (I) (particularly guanine) and titanium dioxide and zinc oxide as inorganic UV filters.

[0079] According to a particular embodiment of the invention and the desired SPF, the total content of the inorganic UV filter relative to the total weight of the composition is from 0.1 wt% to 30 wt%, particularly from 0.5 wt% to 20 wt%, more particularly from 1 wt% to 30 wt%, particularly from 2 wt% to 20 wt%. According to a particular embodiment, the total content of the inorganic UV filter relative to the total weight of the composition is from 1 wt% to 15 wt%, preferably from 5 wt% to 10 wt%.

[0080] For care compositions, especially sun protection compositions, it is advantageous to seek an SPF in the range of 10 to 50, especially 10 to 30, preferably 15 to 30.

[0081] For cosmetic compositions, such as foundation, an SPF range of 5 to 15 would be advantageously sought.

[0082] According to a specific implementation scheme, the sun protection factor (SPF) is determined in vitro using a protocol based on the methods described in the following publications: Validation of an In vitro sun protection factor (SPF) method inblinded ring-testing. Pissavini, M., et al. (2018), Int J Cosmet Sci, 40: 263-268. (https: / / doi.org / 10.1111 / ics.12459).

[0083] As described in the examples below, each formulation was administered at doses of 1.3 and 1.2 mg / cm³, respectively. 2 The ratio was applied to 3 HD6 PMMA boards (HelioScreen) and 3 SB6 PMMA boards (HelioScreen). The spreading was performed using an HD-SPREADMASTER robot (HelioScreen; the application probe was covered with nitrile finger sleeves pre-saturated with the product).

[0084] To measure blank spectra, plates of each type were prepared using 15 μL of petroleum jelly. Absorbance was measured using an OL756 spectroradiometer (OPTRONICS LABORATORIES). In vitro SPF values ​​were then calculated using the following formula: , in E(λ) = the erythema spectrum described in CIE I(λ) = Total spectral irradiance at midsummer, noon, and 40°N; dλ = No measurement (1 nm) , in CHD6 = 0.225 CSB6 = 0.800 Those skilled in the art will adjust the respective contents of the inorganic UV filter (TiO2 and / or ZnO) and the nitrogen-containing compound (especially guanine) of formula (I) accordingly to achieve this SPF protection performance while reducing the white appearance of the composition or film applied to the skin (for skin care compositions) and the effect on color variation (for cosmetic compositions).

[0085] In the case of a binary combination (one inorganic UV filter and one nitrogen-containing compound of formula (I) (e.g., guanine)), a ratio of 2:1 to 1:2, preferably 1:1, of the inorganic UV filter to the nitrogen-containing compound of formula (I) can be used advantageously.

[0086] If a sunscreen composition with a high SPF is sought, the composition contains at least TiO2 as an inorganic UV filter.

[0087] In the case of a ternary combination (two inorganic UV filters and one nitrogen-containing compound of formula (I) such as guanine), a ratio of 2:2:1 to 1:1:2, preferably 1:1:1, of inorganic UV filter 1, inorganic UV filter 2 and nitrogen-containing compound of formula (I) can be used.

[0088] Therefore, for care compositions, especially sun protection compositions, the content of inorganic UV filters is typically 10% to 20% by weight relative to the total weight of the composition, especially 5% to 10% by weight.

[0089] Furthermore, the content of nitrogen-containing compounds (especially guanine) in formula (I) is typically 1% to 20% by weight, especially 5% to 10% by weight, relative to the total weight of the composition.

[0090] Therefore, for cosmetic compositions, especially foundation compositions, the total content of inorganic UV filters is typically 1% to 10% by weight, especially 2% to 10% by weight, relative to the total weight of the composition.

[0091] Furthermore, the content of nitrogen-containing compounds (especially guanine) in formula (I) is typically 0.5% to 10% by weight, especially 1% to 5% by weight, relative to the total weight of the composition.

[0092] According to a particular embodiment, the care composition or sunscreen composition according to the invention will contain at least: (i) The nitrogen-containing compound of formula (I) (especially guanine), in a content of 1% to 10% by weight relative to the total weight of the composition, preferably 5% to 10% by weight, and (ii) One or more inorganic UV filters, preferably selected from TiO2 and ZnO, wherein the total content is from 1% to 15% by weight, preferably from 5% to 10% by weight, relative to the total weight of the composition.

[0093] The composition according to the invention, especially when it contains at least TiO2 as an inorganic UV filter, typically has an SPF in the range of 10 to 30, and preferably 15 to 30.

[0094] According to a particular embodiment, the cosmetic composition according to the invention will comprise at least: (i) The nitrogen-containing compound of formula (I) (especially guanine), in a content of 1% to 5% by weight relative to the total weight of the composition, and (ii) One or more inorganic UV filters, preferably selected from TiO2 and ZnO, in a total content of 2% to 10% by weight relative to the total weight of the composition.

[0095] The composition according to the invention typically has an SPF in the range of 5 to 15.

[0096] According to a particular embodiment, the composition of the present invention does not contain any sunscreen agent other than (i) the nitrogen-containing compound of formula (I) and (ii) the inorganic UV filter described above; in particular, it does not contain soluble sunscreen agents.

[0097] "Soluble" sunscreens should be understood in particular to mean organic UV filters that can be completely dissolved in a liquid aqueous phase in molecular form or in colloidal form (e.g., micelles) in a liquid aqueous phase.

[0098] Oil phase The compositions of the present invention comprise an oil phase.

[0099] "Oil phase" should be understood as referring to oil or a mixture of oils that are miscible with each other.

[0100] "Oil" should be understood as referring to a fatty substance that is liquid at 25°C and atmospheric pressure and is insoluble in water.

[0101] The oil may be selected from hydrocarbon oils, silicone oils, and mixtures thereof.

[0102] According to the present invention, "hydrocarbon oil" should be understood to mean oil that mainly contains hydrogen atoms and carbon atoms.

[0103] According to the present invention, "silicone oil" should be understood to mean an oil containing at least one silicon atom, especially at least one Si-O group.

[0104] Hydrocarbon oil is preferred.

[0105] In particular, straight chains or branched chains C8-C can be mentioned. 19 Alkanes, oils selected from plant-derived hydrocarbon oils, C 10 -C 40 Synthetic ethers, C 10 -C 40 Synthetic esters, C 12 -C 26 fatty alcohols and C 12 -C 22 Higher fatty acids and their mixtures.

[0106] According to a particular and preferred embodiment, the composition comprises one or more straight-chain or branched C8-C chains. 19 Alkanes, especially: C8-C 16 Isoparaffins (also known as isoparaffins), such as isododecane, isodecane, and isohexadecane, as well as oils such as those marketed under the trade names ISOPAR® or PERMETYL®, Straight-chain alkanes, which have - C9-C 17 C 10 -C 14 C 11 -C 13 Hydrocarbon chains, such as mixtures of undecane and tridecane, are marketed by BASF CareCreations under the name Cetiol® Ultimate. - C9-C 12 C 12 -C 14 Hydrocarbon chains, such as those produced by BIOSYNTHIS under the name VEGELIGHT® SILK (INCI name C9- 12 Alkanes), those sold by VEGELIGHT® 1214LC, - n-Dodecane (C 12 ) and n-tetradecane (C 14 ), especially those sold by Sasol as reference products PARAFOL® 12-97 and PARAFOL® 14-97 respectively, and - C 15 -C 19 Hydrocarbon chains, such as those marketed by Seppic under the name EMOGREEN® L15, and its mixtures.

[0107] According to a preferred embodiment, the composition comprises at least one component selected from C9-C. 12 Mixtures of alkanes, C 15 -C 19 Mixtures of alkanes and mixtures of their mixtures.

[0108] According to another particular embodiment, the composition comprises at least one ester oil.

[0109] "Ester oils" (polar) especially include: - Hydroxy esters, preferably hydroxy esters with a total carbon number of 35 to 70, such as polyglycerol-2 triisostearate, lactate isostearate, octyl dodecyl hydroxystearate, diisostearate malate, propyl gallate; glyceryl stearate; diethylene glycol diisonononate; - Fatty acid esters, especially fatty acid esters with 4 to 22 carbon atoms, - Synthetic esters, such as oils of the formula R1COOR2, where R1 represents a straight-chain or branched fatty acid residue containing 4 to 40 carbon atoms, and R2 represents a hydrocarbon chain, especially a branched chain containing 4 to 40 carbon atoms, provided that R1+R2≥16, for example, isononyl isononanoate, ethyl 2-hexyl palmitate, octyl dodecyl neopentyl ester, octyl-2-dodecyl stearate, isostearate isostearate, octyl-2-dodecyl benzoate, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, 2-ethylhexyl palmitate, 2-hexyldecyl laurate, 2-octyldecyl palmitate, 2-octyldodecyl myristate, 2-diethylhexyl succinate; - Straight-chain fatty acid esters with a total carbon number ranging from 35 to 70; - Esters of aromatic acids and alcohols containing 4 to 22 atoms; - Fatty alcohols or branched C 24 -C 28 Fatty acid esters; - A polyester obtained by esterification of at least one hydroxylated carboxylic acid triglyceride with an aliphatic monocarboxylic acid and an aliphatic dicarboxylic acid (optionally unsaturated); and its mixtures.

[0110] According to a particular and preferred embodiment, the composition of the present invention comprises at least one selected from C9-C. 12 Or C 15 -C 19 A mixture of alkane mixtures and ester oils.

[0111] The following reference products can be mentioned in particular: - VEGELIGHT 1214 LC D, its INCI name is C 9-12 Alkane and coco-caprylate / caprate (C9-12 ALKANE and COCO-CAPRYLATE / CAPRATE), from BIOSYNTHIS. - CETIOL C 5C MB, its INCI name is COCO-CAPRYLATE / CAPRATE and TOCOPHEROL, from BASF. And a mixture thereof is preferred.

[0112] The oil phase of the composition according to the invention is typically 20% to 55% by weight relative to the total weight of the composition, preferably 30% to 45% by weight.

[0113] Aqueous phase The compositions of the present invention typically also contain an aqueous phase.

[0114] The aqueous phase of the composition comprises water and optionally a water-soluble solvent.

[0115] According to the present invention, "water-soluble solvent" should be understood to mean a compound that is liquid at room temperature and miscible with water (miscible in water at 25°C and atmospheric pressure greater than 50% by weight). These particularly include: - Lower C1-C5 monools, such as ethanol, isopropanol and mixtures thereof, preferably ethanol; - C2-C8 diols, such as ethylene glycol, propylene glycol, 1,3-butanediol, pentanediol, dipropylene glycol and mixtures thereof, preferably C3-C5 diols; - C2-C 32 Polyols, such as glycerol, polyglycerol, polyethylene glycol, and mixtures thereof, and its mixtures.

[0116] It may also include hydrophilic gelling agents, antioxidants, preservatives, and mixtures thereof.

[0117] The aqueous phase of the composition according to the invention is typically 45% to 80% by weight relative to the total weight of the composition, preferably 55% to 70% by weight relative to the total weight of the composition.

[0118] Therefore, according to a particular embodiment, the composition of the present invention further comprises one or more additional components selected from the following: glycols, C2-C5 monools, oils, fatty acid esters, fatty acids, dispersants, emulsifiers, gelling agents, film-forming agents, fillers, dyes (especially pigments), antioxidants, fragrances, preservatives, cosmetic active ingredients, and mixtures thereof.

[0119] Dyes According to a particular embodiment of the invention, particularly for colored care or cosmetic compositions, the composition comprises at least one dye.

[0120] Within the meaning of this invention, "dye" should be understood to mean a compound that, when formulated in sufficient quantities in a suitable cosmetic medium, can produce colored optical effects.

[0121] The dyes may be selected from organic or inorganic dyes, materials with optical effects, and mixtures thereof, which may or may not be soluble in the oil phase of the present invention.

[0122] According to a particular embodiment, the dye is a pigment, particularly selected from mineral pigments, organic pigments, and mixtures thereof.

[0123] "Pigment" should be understood as referring to white or colored mineral or organic particles that are insoluble in aqueous solution and are intended to color and / or opaque the resulting sediment.

[0124] According to a particular embodiment, the pigment is particularly selected from inorganic and / or organic pigments, composite pigments (based on inorganic and / or organic materials), pearlescent substances or pearlescent pigments and mixtures thereof.

[0125] "Mineral pigments" include, for example, titanium dioxide (rutile or anatase), optionally with surface treatment; black, yellow, red and brown iron oxides; manganese violet; ultramarine blue; chromium oxide, hydrated chromium oxide and iron blue.

[0126] "Organic pigments" include, for example, pigments D&C Red No. 19, D&C Red No. 9, D&C Red No. 22, D&C Red No. 21, D&C Red No. 28, D&C Yellow No. 6, D&C Orange No. 4, D&C Orange No. 5, D&C Red No. 27, D&C Red No. 13, D&C Red No. 7, D&C Red No. 6, D&C Yellow No. 5, D&C Red No. 36, D&C Red No. 33, D&C Orange No. 10, D&C Yellow No. 6, D&C Red No. 30, D&C Red No. 3, D&C Blue No. 1, carbon black, and lakes based on cochineal red.

[0127] According to a particular embodiment, the composition of the present invention comprises at least one iron oxide.

[0128] Advantageously, the pigment is surface-treated with at least one hydrophobic or lipophilic treatment agent to better disperse it in the oil phase. The hydrophobic treatment agent is particularly selected from metal soaps, N-acylated amino acids or their salts, lecithin and its derivatives, isopropyl triisostearyl titanate, diisostearyl sebacate, natural plant or animal waxes, synthetic polar waxes, fatty esters, phospholipids and mixtures thereof, especially N-acylated amino acids or their salts.

[0129] When the composition contains dyes, especially pigments, particularly in the case of color care or cosmetic compositions, their content is typically from 0.1% to 25% by weight, preferably from 8% to 15% by weight, relative to the total weight of the composition.

[0130] preparation The composition is preferably intended for application to the skin and / or lips, particularly the skin of the face and / or body.

[0131] According to a particular embodiment, the compositions of the present invention are skin and / or lip care compositions, sun protection compositions, or cosmetic compositions, particularly care compositions or foundations.

[0132] According to the first embodiment, it is a composition for use with keratinous materials, particularly for the skin of the body or face, preferably for facial care and / or sun protection.

[0133] In particular, the compositions of the present invention may be provided in the form of anti-aging care compositions for the skin of the body or face, especially the face.

[0134] According to another embodiment, the compositions of the present invention may be provided in the form of photoprotective compositions (e.g., sunscreens).

[0135] According to another embodiment, it is a cosmetic composition for facial skin, particularly a foundation.

[0136] In particular, it can be provided in the form of emulsions, especially in the form of oil-in-water emulsions or water-in-oil emulsions, lotions, aqueous gels, emulsions, oils, serums, creams or ointments.

[0137] According to a particular embodiment, the compositions of the present invention are provided in the form of a water-in-oil (W / O) emulsion.

[0138] In the case of care compositions, especially sun protection care compositions, they can be creams, lotions, oils, ointments or self-tanning agents, particularly SPF 50 or SPF 30 sunscreen lotions, SPF 50 or SPF 30 sunscreen lotions, SPF 15 sunscreen oils, after-sun lotions, after-sun balms, self-tanning agents or after-sun oils for the face and / or body.

[0139] According to one particular embodiment, the composition is a protective composition applied before exposure to sunlight.

[0140] According to one particular embodiment, the composition is applied after sun exposure to enhance tanning and bronzening, improve the durability of tanning and bronzening, or provide a cooling and comfortable sensation to the skin.

[0141] It can also be an oil, balm, or stick used on the lips.

[0142] In the case of cosmetic compositions, these can be foundation, primer, or lipstick.

[0143] Methods and uses The present invention also relates to a non-therapeutic cosmetic method for caring for and / or beautifying the skin and / or lips, comprising applying a composition as defined in the present invention to said skin and / or said lips.

[0144] In the context of this invention, the keratin material (skin and / or lips) is healthy, i.e., does not present a condition or ailment belonging to a pathological state (an "unhealthy" subject suffering from a pathological condition).

[0145] According to a particular embodiment, the non-therapeutic cosmetic method according to the invention aims to limit skin darkening and / or improve the color and / or evenness of skin tone.

[0146] According to another embodiment, the non-therapeutic cosmetic method according to the invention is intended to prevent and / or treat signs of skin aging.

[0147] "Prevention" means reducing and / or slowing down the appearance of signs of skin aging, especially changes in the biomechanical properties of the epidermis associated with the degradation of collagen and elastin fibers.

[0148] According to a particular and preferred embodiment, the composition of the invention is applied to the skin before and during sun exposure to protect the skin from UV radiation.

[0149] According to another embodiment, the composition of the present invention is applied to the skin after sun exposure to enhance tanning and bronzening, improve the durability of tanning and bronzening, or provide a cooling and comfortable sensation to the skin.

[0150] The present invention also relates to the use of a nitrogen-containing compound (preferably guanine) of formula (I) as defined above as an enhancer in a composition comprising one or more inorganic UV filters for protecting keratinous materials from UV radiation and / or reducing whitening of the composition containing the inorganic UV filter and / or whitening of the skin when the composition is applied.

[0151] The applicant has indeed demonstrated that the use of guanine can enhance the protective effect of inorganic UV filters. This is referred to as an "SPF enhancer" or "sunscreen activator." The presence of guanine in the compositions of this invention does indeed reduce the content of inorganic UV filters while maintaining the protective effect (SPF).

[0152] The examples shown below demonstrate that, according to the invention, compositions containing a nitrogen-containing compound (e.g., guanine) of formula (I) can increase SPF by at least 10%, particularly at least 20%, and preferably at least 30%, compared to the same compositions without the nitrogen-containing compound of formula (I).

[0153] In other words, the combination of nitrogen-containing compounds (e.g., guanine) of formula (I) with inorganic UV filters has a synergistic effect on SPF protection.

[0154] Therefore, this enhancing effect of the nitrogen-containing compound of formula (I) can reduce the content of inorganic UV filter in the composition, and thus reduce the disadvantages of inorganic UV filter (a non-biodegradable compound that gives the composition and the film applied to the skin a white appearance, making it difficult to use inorganic UV filter in the dark color range of cosmetic compositions, and causing the film of skin care compositions, especially sunscreen compositions, to have an unsightly white appearance).

[0155] Another object is the use of compositions comprising a nitrogen-containing compound of formula (I) according to the invention and one or more inorganic UV filters for the prevention and / or treatment of the harmful effects of ultraviolet radiation on the skin and / or lips. In particular, the compositions prevent photoaging of the skin.

[0156] The invention will now be described by way of the following non-limiting examples. Unless otherwise stated, all percentages refer to weight percentages relative to the total weight of the composition.

[0157] Example Example 1: The effect of combining guanine with UV filters in foundation (SPF and tone) Prepare foundation compositions and describe them in the table below: [Table 1] [Table 2] These compositions are prepared at room temperature according to the following scheme, except for the candlewood resin, which requires preheating.

[0158] The A1 phase was heated to 95°C using a water bath.

[0159] Weigh the A3 phase components (pigment, TiO2, ZnO, and guanine) into a dish, homogenize them thoroughly with a scraper, and then grind them using a three-roll mill.

[0160] Weigh the A4 phase into a dish, homogenize it thoroughly with a scraper, and then grind it using a three-roll mill.

[0161] Weigh out the components of aqueous phase B1, and after all the powders have been fully dissolved, add phase B2 and homogenize with RAYNERI.

[0162] Weigh the components of the fat phase A2 and homogenize the phase with ULTRA-TURRAX for 5 min.

[0163] Phase A1 was added to phase A2, and the mixture was homogenized for 5 min using ULTRA-TURRAX.

[0164] Then add phase A3 to A1+A2, and then stir the mixture in RAYNERI for 10 min.

[0165] Under RAYNERI stirring, the mixture (B1+B2) was gradually added to the phase (A1+A2+A3) to form an emulsion; then B3 was added under RAYNERI stirring, followed by C, and the whole mixture was stirred at 950 rpm for 15 min.

[0166] The composition is then evaluated according to various criteria (SPF and body color).

[0167] In vitro SPF The sun protection factor (SPF) was determined in vitro using a protocol based on the methods described in the following publications: Validation of an In vitro sun protection factor (SPF) method in blinded ring-testing. Pissavini, M., et al. (2018), Int J Cosmet Sci, 40: 263-268. (https: / / doi.org / 10.1111 / ics.12459).

[0168] Each formulation was administered at doses of 1.3 and 1.2 mg / cm³, respectively. 2 The ratio was applied to 3 HD6 PMMA boards (HelioScreen) and 3 SB6 PMMA boards (HelioScreen). Spreading was performed using an HD-SPREADMASTER robot (HelioScreen), with the application probe covered with nitrile finger sleeves pre-saturated with the product.

[0169] To measure blank spectra, plates of each type were prepared using 15 μL of petroleum jelly. Absorbance was measured using an OL756 spectroradiometer (OPTRONICS LABORATORIES). In vitro SPF values ​​were then calculated using the following formula: , in E(λ) = the erythema spectrum described in CIE I(λ) = Total spectral irradiance at midsummer, noon, and 40°N; dλ = No measurement (1 nm) , in CHD6 = 0.225 CSB6 = 0.800 Material body color measurement Place the formulation into a 0.5 mm deep cup; smooth the surface of the formulation, then place the cup in the holder. Immediately perform colorimetric measurements using an MA98 multi-angle color spectrophotometer (XRITE) placed on the holder.

[0170] The measurement and operating conditions are as follows: Direct geometry: the light source is at 45° relative to the normal, and the measurement angle is at 0° relative to the normal; the light source is D65; the observer's angle is 10°.

[0171] Then, the color values ​​are calculated in the CIELAB color space. The lightness difference ΔL* and saturation difference ΔC* are calculated based on the values ​​obtained from the control formulation and various test formulations (NF EN ISO / CIE 11664-4:2019).

[0172] A positive ΔL* value indicates that the sample is brighter than the control, while a negative ΔL* value indicates that the sample is darker than the control. A positive ΔC* value indicates that the sample is more vibrant than the control, while a negative ΔC* value indicates that the sample is darker than the control.

[0173] The results are presented in the table below: [Table 3] These results indicate that the combination of guanine with inorganic UV filters (TiO2 or ZnO) provides SPF protection close to the control, but with a reduced white appearance and improved hue brightness (ΔL* negative and ΔC* positive). The hue is less dull and grayish compared to the indicator. Therefore, the use of guanine results in a brighter hue and SPF protection across the entire hue range.

[0174] [Table 4] These illustrative embodiments of the present invention confirm the previous results: due to the presence of guanine, near-control SPF protection is maintained and the hue is improved.

[0175] Example 2: The effect of guanine combined with inorganic UV filter in care compositions (SPF and coverage). [Table 5] These compositions were prepared at room temperature using RAYNERI according to the following protocol: The A4 phase was transferred to a small three-roll mill.

[0176] Phase A1 was homogenized with TURAX, and then phases A2 and A3 were added sequentially, with the mixture homogenized with TURAX after each introduction until a homogeneous phase was obtained.

[0177] Phase B was prepared as follows: water was heated to 70°C to dissolve chlorphenesin, then cooled, and then each phase was added sequentially, stirring for 5 min between each RAYNERI treatment.

[0178] Then, using RAYNERI, phase B was added to phase A through a mesh screen, the rotation speed was increased to 900 rpm, and then stirred at 900 rpm for 15 min.

[0179] These compositions were then evaluated according to various criteria: SPF was determined according to the scheme described in Example 1, and opacity (coverage) was determined according to the following scheme.

[0180] Opacity (covering power) measurement The formulation is spread onto a "comparison card" type carrier having at least one black area and one white area. Spreading is performed using an automated device and BIRD-type rods with a gap of 30 µm.

[0181] The film was dried in a controlled manner at 40°C for 2 h.

[0182] After drying, measurements were taken using a spectrophotometer (COLOR I7800, XRITE).

[0183] The measurement conditions are: d / 8° integrating sphere geometry, including specular reflection.

[0184] For each sample, measurements were performed: Yft was measured on the black area of ​​the color chart coated with the cosmetic product, and Yfb was measured on the white area of ​​the color chart coated with the cosmetic product. The resulting luminance Y ratio was then calculated. O = Opacity = Yft / Yfb Opacity can range between 0 (zero opacity) and 100 (total opacity).

[0185] For each formulation, three measurements were performed, and the resulting mean and standard deviation were calculated to represent the opacity.

[0186] The results are shown below.

[0187] [Table 6] These results particularly indicate that: - At the equivalent level, compared with the ZnO + TiO2 combination, the guanine + TiO2 combination improved the SPF of TiO2 (guanine 41.0 vs ZnO 30.6) while having acceptable masking power; - Guanine improved the SPF of ZnO (7.0 vs 4.9) while maintaining the hiding power, and did not make the composition appear whiter.

[0188] Therefore, the use of guanine in sunscreen compositions containing high levels of inorganic UV filters can improve SPF while maintaining acceptable coverage, without leaving the skin appearing white after application.

Claims

1. A cosmetic composition for use on skin and / or lips, comprising, in a physiologically acceptable medium, at least: (i) Nitrogen-containing compounds of formula (I) ， in Indicates a single bond or a double bond. R 1 and R 3 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl), R 2 and R 4 Each is independently selected from H, oxo group, thio group, and NR. x R y Halogenated or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl), R x and R y Independently representing H or C1-C6 alkyl, R 5 and R 6 Each is independently selected from H, oxo group, thio group, or optionally substituted C1-C group. 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl), or R 5 and R 6 Together with the carbon atoms they are bonded to, they form optionally substituted aryl or optionally substituted imidazolyl groups, and (ii) One or more inorganic UV filters, Its features are, The nitrogen-containing compound of formula (I) preferably contains guanine at a content of 0.5% to 20% by weight relative to the total weight of the composition.

2. The composition according to claim 1, characterized in that, The nitrogen-containing compound of formula (I) corresponds to the following formula (IA): ， in R 7 Selected from H, C1-C6 alkyl, oxo, OH, thio, SH and O-C1-C6 alkyl. and R 1 To R 4 As mentioned above, and R 8 and R 9 Each of the following is independent of or selected from H, or optionally substituted C1-C 12 Aliphatic chains, wherein one or more of the aliphatic chains, preferably one to four methylene units, are optionally replaced by O, C(O), NH or N (C1-C6 alkyl).

3. The composition according to claim 1 or claim 2, characterized in that, In the nitrogen-containing compounds of formula (IA), R 1 and R 3 Independently does not exist or represents H, R 2 Selected from H, oxo group and NH2, R 4 It is an oxygen group, R 7 Selected from H and oxo groups.

4. The composition according to any one of claims 1 to 3, characterized in that, The nitrogen-containing compounds of formula (IA) are selected from the following compounds: ， Xanthine, hypoxanthine, uric acid and guanine are preferred, with guanine being more preferred.

5. The composition according to any one of claims 1 to 4, characterized in that, The inorganic UV filter is selected from zinc oxide, titanium dioxide, and mixtures thereof.

6. The composition according to claim 5, characterized in that, It contains at least titanium dioxide.

7. The composition according to any one of claims 1 to 6, characterized in that, The total content of the inorganic UV filter is from 0.1% to 30% by weight relative to the total weight of the composition, particularly from 0.5% to 20% by weight, and even more particularly from 1% to 30% by weight relative to the total weight of the composition, particularly from 2% to 20% by weight.

8. The composition according to any one of claims 1 to 7, characterized in that, The nitrogen-containing compound of formula (I) preferably contains guanine at a content of 1% to 10% by weight relative to the total weight of the composition.

9. The composition according to any one of claims 1 to 8, characterized in that, It also contains one or more additional ingredients selected from the following: glycols, C2-C5 monools, oils, fatty acid esters, fatty acids, dispersants, emulsifiers, gelling agents, film-forming agents, fillers, pigments, and mixtures thereof.

10. The composition according to any one of claims 1 to 9, characterized in that, The composition contains a total pigment content of 0.1% to 25% by weight, particularly 8% to 15% by weight, relative to the total weight of the composition.

11. The composition according to any one of claims 1 to 10, characterized in that, The composition is a skin and / or lip care composition, sun protection composition, or cosmetic composition, particularly a care composition or foundation.

12. The composition according to any one of claims 1 to 11, characterized in that, It takes the form of emulsions, lotions, aqueous gels, milks, oils, serums, creams, or ointments, especially water-in-oil emulsions.

13. The nitrogen-containing compound of formula (I) according to any one of claims 1 to 4, preferably guanine, is used as an agent for reducing whitening of the composition containing one or more inorganic UV filters in a composition containing inorganic UV filters.

14. A composition comprising a nitrogen-containing compound of formula (I) according to any one of claims 1 to 4 and one or more inorganic UV filters, for use in preventing and / or treating the harmful effects of ultraviolet radiation on the skin and / or lips.

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