Selenium-rich lipid-lowering liver-protecting solid beverage and preparation method thereof

Abstract

The application discloses a kind of selenium-rich lipid-lowering liver-protecting solid beverage and preparation method thereof, it is related to health-care product beverage technical field, product is according to medicine and food homologous lord and minister system compatibility, with ternary compound selenium source as lord material, collocation lipid-lowering subordinate material, blend seasoning and functional subordinate material, compound dietary fiber, rely on gynostemma pentaphyllum total saponins, hawthorn flavone and form active synergic system, product uses core-shell double-layer composite effervescent granule structure, is divided into instant, slow-release component, adds natural anti-knot agent, selenium content is uniform and stable;Preparation method is sequentially through raw material probiotic pre-fermentation, low-temperature wall-breaking ultrafine grinding, subsection temperature control countercurrent extraction, low-temperature concentration freeze-drying, double-layer microcapsule embedding, gradient mixing, low-temperature non-thermal sterilization is made.The selenium-rich lipid-lowering liver-protecting solid beverage and preparation method thereof have the effects of selenium supplementation, lipid-lowering and liver protection, and the low glycemic formula is suitable for special groups.The beverage is convenient to drink, stable in quality, and suitable for long-term consumption by the general public and related groups.

Description

Technical Field

[0001] This invention relates to the field of health food and beverage technology, specifically to a selenium-enriched lipid-lowering and liver-protecting solid beverage and its preparation method. Background Technology

[0002] Selenium is one of the most important trace elements in the human body. In the human body, selenium typically exerts its biological functions in the form of selenoproteins. Different selenoproteins have different physiological functions, playing important roles in anti-inflammatory and analgesic effects, immune regulation, free radical scavenging, cancer prevention and treatment, delaying aging, and antagonizing heavy metals. Selenium also has antioxidant, anti-aging, and immune-boosting preventative and health-promoting effects. Selenium-enriched health drinks are made from natural selenium-rich water or selenium-rich foods. Selenium is an essential trace element for the human body. These products are processed using extraction, blending, and sterilization techniques to retain effective nutrients. They have a refreshing and palatable taste, and long-term moderate consumption can supplement the body's selenium needs, meeting the public's health needs. The drinks are diverse, including selenium-enriched drinking water, fruit and vegetable drinks, and herbal drinks. Strict hygiene and selenium content standards are maintained throughout the production process.

[0003] In the prior art, such as the solid beverage for clearing liver and lowering lipids and its preparation method with application number 201210353141.2, the technical solution is as follows: using the following raw materials in parts by weight: 16-40 parts of wolfberry, 14-25 parts of chrysanthemum, 15-20 parts of cassia seed, 15-45 parts of hawthorn, and 240-380 parts of sucrose, the beverage is obtained by decoction and concentration, mixing and granulation, drying and sieving. Among them, wolfberry can nourish the liver, kidneys, and lungs; chrysanthemum can dispel wind and clear heat, calm the liver and improve eyesight, detoxify and reduce swelling; cassia seed can clear the liver and improve eyesight, promote urination and bowel movement; and hawthorn can aid digestion, strengthen the stomach, and promote qi circulation and blood circulation. The above four medicinal and edible ingredients are combined to form a formula that has the effects of clearing the liver and lowering lipids, improving eyesight and relieving fever, aiding digestion and strengthening the stomach, protecting the cardiovascular system and enhancing immunity. The solid particles prepared by this method are loose in shape, free of lumps, and contain few impurities. The solid beverage retains the aroma of the raw materials, tastes sweet and slightly sour, and contains no added preservatives.

[0004] Currently, mainstream selenium-enriched lipid-lowering and liver-protecting solid beverages on the market suffer from the following technical defects: most existing products use single inorganic selenium or pure plant selenium for exogenous selenium supplementation. Inorganic selenium has low bioavailability and poses a risk of poisoning from excessive intake. Pure plant selenium content fluctuates greatly and is unevenly distributed, resulting in limited overall lipid-lowering, liver-protecting, and selenium-supplementing effects. Most products do not employ the principle of layering and design based on the theory of food and medicine homology. Some products add a large amount of sucrose to adjust the taste, resulting in a high glycemic index, making them unsuitable for special populations such as those with hyperlipidemia, obesity, diabetes, and fatty liver. Herbal ingredients themselves have a bitter and astringent taste, which seriously affects the drinking experience.

[0005] In view of this, in-depth research was conducted on the above issues, which led to the creation of this case.

[0006] To address the aforementioned issues, an innovative design was developed based on the existing lipid-lowering and liver-protecting solid beverage. Summary of the Invention

[0007] The purpose of this invention is to provide a selenium-enriched lipid-lowering and liver-protecting solid beverage and its preparation method, so as to solve the problems of selenium source selection and compatibility defects and insufficient rationality of raw material formulation mentioned in the background art.

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] A selenium-enriched lipid-lowering and liver-protecting solid beverage includes raw material components. These components are formulated according to a traditional Chinese medicine-food homology system, comprising principal, assistant, adjuvant, and guiding ingredients. The principal ingredient comprises 30-40 parts, which is a ternary compound selenium source composed of organic plant selenium, active yeast selenium, and nano-chelated selenium. The organic plant selenium includes selenium-enriched kudzu root, selenium-enriched wolfberry, and selenium-enriched cassia seed. The assistant ingredient comprises 16-28 parts, which includes hawthorn, lotus leaf, and gynostemma pentaphyllum. The adjuvant ingredient comprises 12-22 parts, which includes schisandra chinensis, chrysanthemum, licorice, and Japanese raisin tree fruit. The guiding ingredient comprises 8-18 parts, which includes fructooligosaccharides and steviol glycosides. The solid beverage also contains 7-17 parts dietary fiber, which is psyllium husk and inulin. The raw material components utilize total saponins from gynostemma pentaphyllum, hawthorn flavonoids, and schisandra lignans to form an active synergistic system.

[0010] Preferably, the organic plant selenium contains 14 parts of selenium-enriched kudzu root, 11 parts of selenium-enriched wolfberry, and 9 parts of selenium-enriched cassia seed. The organic plant selenium also contains at least 5.5 parts of selenium-enriched broken cell wall cordyceps, selenium-enriched golden camellia, fermented selenium-enriched black bean, and fermented dandelion. The ternary composite selenium source contains 0.6 parts of active yeast selenium and 0.5 parts of nano-chelated selenium.

[0011] Using the above technical solution, this formula limits the specific components and proportions of organic plant selenium. Based on selenium-enriched kudzu root, selenium-enriched goji berries, and selenium-enriched cassia seeds, it is compounded with a variety of selenium-enriched ingredients such as selenium-enriched cordyceps militaris, and combined with quantitative active yeast selenium and nano-chelated selenium to form a ternary composite selenium source. The multiple selenium-enriched herbs further enrich the nutrition and active substances. The three selenium sources complement each other to improve the stability of selenium and the absorption rate by the human body, avoiding the problems of uneven content and low utilization rate of single selenium sources.

[0012] Preferably, the ingredients include 10 parts hawthorn, 6 parts lotus leaf and 7 parts gynostemma pentaphyllum, the seasonings include 5 parts schisandra, 4 parts chrysanthemum, 3 parts licorice and 5 parts jujube, the spice contains 8 parts fructooligosaccharide and 0.4 parts steviol glycoside, and the dietary fiber contains 6 parts psyllium husk and 5 parts inulin.

[0013] Using the above technical solution, the formula precisely defines the weight proportions of the principal, assistant, adjuvant, and guiding ingredients, dietary fiber, and flavoring agents. The proportions of each component are scientifically and rationally allocated. Hawthorn, lotus leaf, and gynostemma pentaphyllum, among other assistant ingredients, primarily target lipid-lowering effects. Schisandra chinensis and chrysanthemum, among other adjuvant ingredients, assist in liver protection and harmonization. Fructooligosaccharides and steviol glycosides replace traditional sucrose to adjust the flavor. Psyllium husk and inulin are added to supplement dietary fiber. The low-glycemic index adjuvants are suitable for people with high blood lipids and high blood sugar. Dietary fiber can also promote intestinal peristalsis. The overall formula takes into account health benefits, taste, and suitability for different population groups.

[0014] Preferably, the solid beverage has a core-shell double-layer composite particle structure. The core layer is composed of selenium-enriched liver-protecting active powder made from a formula of principal ingredients, secondary ingredients, seasonings, and dietary fiber. The outer shell is composed of a lipid-lowering flavor layer made from a formula of auxiliary ingredients. The solid beverage is an effervescent form, and food-grade citric acid, sodium bicarbonate, and plant buffers are added to the formula to form a natural acid-base effervescent system. Furthermore, the solid beverage is an independently dispensed dosage form, with each bag containing two components: instant granules and sustained-release granules.

[0015] Using the above technical solution, the product adopts a core-shell double-layer composite granule and effervescent formulation. The core layer carries the liver-protecting active ingredients, while the outer shell achieves lipid-lowering and flavoring. The layered structure can distinguish the release rhythm of active ingredients, the effervescent system dissolves quickly, and it is convenient to brew. The individually quantitative packaging is divided into two components: instant and sustained-release, which can realize the time-sharing release of effective ingredients and prolong the duration of action. The dosage form design optimizes the drinking experience. At the same time, the layered structure can isolate different active substances and avoid mutual interference between ingredients, so as to maximize the preservation of lipid-lowering, liver-protecting, and selenium-supplementing activities and meet the needs of daily convenient drinking.

[0016] Preferably, the solid beverage also contains natural anti-caking agents, namely magnesium stearate and modified starch. After the solid beverage is premixed with additives and dispersed by airflow, the selenium content per gram of powder has an error of ≤5%, and the formula is precisely pH controlled to form an acid and alkali resistant system.

[0017] By adopting the above technical solution, adding magnesium stearate and modified starch as natural anti-caking agents can effectively prevent the powder from absorbing moisture and clumping, ensuring the flowability of the particles and the brewing effect. After premixing with additives and air dispersion treatment, the selenium element is highly uniformly distributed, avoiding local selenium content exceeding or falling short of the standard. At the same time, by creating an acid and alkali resistant system through pH control, the product is stable in different water quality and storage environments, the active ingredients are not easily degraded, the shelf life is greatly extended, and the long-term use effect is guaranteed.

[0018] A method for preparing a selenium-enriched lipid-lowering and liver-protecting solid beverage, the method comprising the following steps: Step 1, Raw material pretreatment: Select all raw materials, and carry out solid-state pre-fermentation of selenium-enriched grains and herbal raw materials with compound probiotics. Then, use low-temperature airflow cell wall breaking combined with ultra-fine pulverization technology to pulverize the fermented raw materials. Step 2, segmented temperature-controlled countercurrent extraction: Based on the dissolution characteristics of different components, a low-temperature segment is used to extract selenium and heat-sensitive liver-protecting components, and a medium-temperature segment is used to extract lipid-lowering flavonoids. Step 3, Low-temperature concentration and freeze-drying: After the extract is concentrated using a vacuum low-temperature membrane, it is freeze-dried into powder, with the temperature not exceeding 50℃ throughout the process. Step 4, double-layer microcapsule encapsulation: double-layer microcapsules are prepared using natural wall materials. The inner layer encapsulates selenium and fat-soluble liver-protecting active ingredients, while the outer layer encapsulates lipid-lowering flavonoids and a taste-masking carrier. Step 5, gradient mixing: Mix the microcapsule powder, dietary fiber, and other ingredients in separate sections at low speeds in stages; Step 6, Low-temperature non-thermal sterilization: The mixed materials are treated with low-temperature irradiation sterilization or pulsed light sterilization to obtain the finished selenium-enriched lipid-lowering and liver-protecting solid beverage.

[0019] Using the above technical solution, this preparation method employs six core processes: raw material fermentation, segmented temperature-controlled extraction, low-temperature freeze-drying, double-layer encapsulation, gradient mixing, and low-temperature non-thermal sterilization. The entire process is designed to protect heat-sensitive active ingredients. Probiotic fermentation converts inorganic selenium into organic selenium, improving absorption efficiency; segmented extraction selectively dissolves different functional substances; low-temperature freeze-drying and non-thermal sterilization avoid high-temperature damage to activity; and double-layer microcapsule encapsulation further locks in nutrients. The entire process is seamlessly integrated, improving raw material utilization while ensuring the core efficacy of the finished product in lowering lipids, protecting the liver, and supplementing selenium, making it suitable for industrial-scale production.

[0020] Preferably, in step one, the pre-fermentation treatment involves adding sterile water and 0.5%-1% glucose as a fermentation starter carbon source to the raw material components, and then fermenting with compound probiotics. The compound probiotics ferment into a compound system of lactic acid bacteria and yeast. The small amount of inorganic selenium contained in the raw material components is converted into bound organic selenium raw material. The plant cell walls are broken by low-temperature airflow to release the bound selenium and active ingredients in the cells. The particle size is then controlled to 800-1200 mesh by ultra-fine grinding.

[0021] Using the above technical solution, step one involves pre-fermentation with a compound probiotic of lactic acid bacteria and yeast, with the addition of trace amounts of glucose to initiate fermentation. This process converts the selenite and other inorganic selenium in the raw materials into easily absorbed bound organic selenium, reducing selenium toxicity and improving bioavailability. Combined with low-temperature airflow cell disruption and ultra-fine pulverization, the plant cell walls are fully broken down, releasing the internal selenium and functional components. The powder has a uniform particle size, dissolves faster and leaves no residue when brewed. The entire pretreatment process optimizes the quality of the raw materials from the source, laying a good foundation for subsequent extraction and granulation.

[0022] Preferably, in step two, the temperature for extracting selenium in the low-temperature stage is controlled at ≤45℃, the temperature for extracting heat-sensitive liver-protecting components is controlled at 35℃-45℃, and the countercurrent time in the low-temperature stage is 1-2 hours; the temperature for extracting lipid-lowering flavonoids in the medium-temperature stage is controlled at 55℃-65℃, and the countercurrent time in the medium-temperature stage is 1-1.5 hours.

[0023] Using the above technical solution, step two employs segmented temperature-controlled countercurrent extraction. The low-temperature segment (≤45℃) extracts selenium and heat-sensitive liver-protecting components, while the 35-45℃ range avoids the inactivation of active substances due to high temperatures. 1-2 hours of countercurrent extraction ensures sufficient extraction. The medium-temperature segment (55-65℃) specifically extracts lipid-lowering components such as hawthorn flavonoids and gypenosides, with an extraction time of 1-1.5 hours balancing efficiency and component integrity. This targeted extraction across temperature zones solves the problem of active ingredient loss caused by traditional one-pot extraction, allowing all three types of effective substances—lipid-lowering, liver-protecting, and selenium-supplementing—to achieve optimal extraction rates, thus enhancing the overall health value of the product.

[0024] Preferably, the natural wall material in step four is one or a combination of maltodextrin, gum arabic, and resistant starch.

[0025] Using the above technical solution, step four selects natural substances such as maltodextrin, gum arabic, and resistant starch as microcapsule wall materials. These natural wall materials are highly safe, have no chemical residues, and meet food-grade production standards. Different wall materials have differentiated encapsulation and sustained-release characteristics, and can be used in combination according to the characteristics of the inner layer selenium element, fat-soluble liver-protecting substances, and the outer layer lipid-lowering flavonoids. This effectively isolates the active ingredients from the damage caused by light, oxygen, and humidity. At the same time, the wall materials can mask the bitter taste of the herbal raw materials, improve the product's taste, and achieve the dual functions of preserving the active ingredients and masking the taste.

[0026] Preferably, the low-speed mixing process in step five avoids frictional heating of the materials, and the sterilization process in step six is ​​heat-free, preserving all functional active ingredients of the raw materials.

[0027] Using the above technical solution, step five involves low-speed, step-by-step mixing in designated areas, with temperature control of the materials throughout the process to prevent friction-induced heating and decomposition of active ingredients. Step six employs low-temperature, non-thermal sterilization methods such as irradiation and pulsed light, which do not generate high temperatures or introduce chemical sterilizing agents, thus fully preserving all functional active substances in the raw materials, such as selenium, flavonoids, and lignans. The low-temperature process system runs through the mixing and sterilization stages, solving the defects of traditional high-temperature sterilization and high-speed mixing that lead to efficacy loss, ensuring stable activity in each batch of finished products and strong consistency in product quality.

[0028] Compared with the prior art, the beneficial effects of the present invention are: the selenium-enriched lipid-lowering and liver-protecting solid beverage and its preparation method, 1. The three-element compound selenium source formula is safe and efficient for selenium supplementation. It uses a three-element compound selenium source composed of organic plant selenium, active yeast selenium, and nano chelated selenium. Unlike traditional single inorganic selenium or pure plant selenium formulas, the three selenium sources complement each other. Plant selenium is natural and mild, yeast selenium has a high absorption rate, and nano chelated selenium has strong stability. At the same time, inorganic selenium is converted into organic selenium through probiotic fermentation, which greatly reduces the risk of selenium intake and improves bioavailability. Combined with a variety of selenium-rich herbal ingredients, the selenium content is evenly distributed with small error. It can achieve scientific selenium supplementation, anti-oxidation, and enhanced immunity, while avoiding the defects of single selenium source content fluctuation and easy poisoning. It is suitable for a wider range of people. 2. The three active ingredients work synergistically to enhance the lipid-lowering and liver-protecting effects. The innovative formula combines three active substances: total saponins of Gynostemma pentaphyllum, hawthorn flavonoids, and schisandra lignans. The scientific combination of these three substances forms a synergistic system, breaking through the limitations of single-ingredient effects. The lipid-lowering, anti-inflammatory, and liver damage repair capabilities achieve a synergistic effect, comprehensively improving problems such as dyslipidemia and liver damage. At the same time, following the theory of medicine and food homology, the formula uses compound selenium source as the principal ingredient and lipid-lowering herbs as the assistant ingredients. The combination of medicinal properties is reasonable. The formula abandons high sucrose and selects low glycemic excipients, taking into account both efficacy and health. It is suitable for special groups such as fatty liver, hyperlipidemia, and hyperglycemia. 3. Dietary fiber constructs a gut-liver coordinated protection system. The formula adds psyllium husk and inulin, two types of dietary fiber, which not only help absorb and break down lipids in the body, enhancing the lipid-lowering effect, but also wraps up excess lipids and metabolic waste in the intestines and excretes them with feces. Dietary fiber nourishes the intestinal flora, protects the intestinal mucosa, improves intestinal metabolic function, reduces the accumulation of intestinal toxins, and indirectly reduces the metabolic burden on the liver, forming a gut-liver coordinated protection system. Unlike ordinary solid beverages that only focus on a single effect, this product forms a protective chain from the inside out, making its health benefits more comprehensive and lasting. 4. The low-temperature targeted preparation process maximizes the retention of active ingredients. The entire preparation process is designed around low-temperature preservation, from low-temperature cell wall breaking of raw materials and segmented temperature-controlled targeted extraction to vacuum low-temperature freeze drying, low-temperature mixing, and non-thermal sterilization. The temperature is strictly controlled throughout the process, and there are no high-temperature processes that would damage heat-sensitive substances. Segmented countercurrent extraction targets the extraction of selenium, liver-protecting components, and lipid-lowering components, maximizing the utilization rate of raw materials. Probiotic fermentation, microencapsulation, and other processes further optimize the state and stability of the components. Compared with traditional decoction and high-temperature drying processes, this process fully preserves active substances such as selenium, flavonoids, and lignans, ensuring the health benefits of the product and making it suitable for industrial mass production. Attached Figure Description

[0029] Figure 1 This is a schematic diagram of the process structure of the preparation method of the present invention;

[0030] Figure 2 This is a table showing the blood lipid test results in mice in Example 2 of the present invention;

[0031] Figure 3 This is a table showing the liver function test results in mice in Example 2 of the present invention. Detailed Implementation

[0032] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] Example 1

[0034] Please see Figure 1 The present invention provides a technical solution:

[0035] A selenium-enriched lipid-lowering and liver-protecting solid beverage includes raw material components formulated according to the traditional Chinese medicine principle of "medicine and food homology," comprising principal, assistant, adjuvant, and guiding ingredients. The principal ingredient consists of 30-40 parts, which is a ternary compound selenium source composed of organic plant selenium, active yeast selenium, and nano-chelated selenium. The organic plant selenium includes selenium-enriched kudzu root, selenium-enriched wolfberry, and selenium-enriched cassia seed. The assistant ingredient consists of 16-28 parts, which are hawthorn, lotus leaf, and gynostemma pentaphyllum. The adjuvant ingredient consists of 12-22 parts, which are schisandra chinensis, chrysanthemum, licorice, and jujube seed. The guiding ingredient consists of 8-18 parts, which are fructooligosaccharides and steviol glycosides. The solid beverage also contains 7-17 parts of dietary fiber, which is psyllium husk and inulin. The raw material components utilize total saponins from gynostemma pentaphyllum, hawthorn flavonoids, and schisandra lignans to form an active synergistic system.

[0036] The organic plant selenium formula contains 14 parts selenium-enriched kudzu root, 11 parts selenium-enriched goji berries, and 9 parts selenium-enriched cassia seeds. It also includes at least one of the following: 5.5 parts selenium-enriched cordyceps militaris, selenium-enriched golden camellia, fermented selenium-enriched black beans, and fermented dandelion. The ternary compound selenium source includes 0.6 parts active yeast selenium and 0.5 parts nano-chelated selenium. Other ingredients include 10 parts hawthorn, 6 parts lotus leaf, and 7 parts gynostemma pentaphyllum. Additional ingredients include 5 parts schisandra chinensis, 4 parts chrysanthemum, 3 parts licorice, and 5 parts Japanese raisin tree fruit. Further ingredients include 8 parts fructooligosaccharides and 0.4 parts steviol glycosides. Dietary fiber includes 6 parts psyllium husk and 5 parts inulin. This formula specifies the exact components and proportions of the organic plant selenium, combining selenium-enriched kudzu root, selenium-enriched goji berries, and selenium-enriched cassia seeds with selenium-enriched cordyceps militaris and other selenium-enriched ingredients. This formula combines selenium-rich ingredients with quantitatively controlled active yeast selenium and nano-chelated selenium to form a ternary complex selenium source. Multiple selenium-rich herbs further enrich the nutritional content and active substances. The three selenium sources complement each other, enhancing the stability and absorption rate of selenium, avoiding the problems of uneven content and low utilization of single selenium sources. The formula precisely defines the weight proportions of the main ingredients, dietary fiber, and flavoring agents, with a scientifically reasonable ratio. Hawthorn, lotus leaf, and gynostemma pentaphyllum are used as supporting ingredients to lower lipids, while schisandra and chrysanthemum assist in liver protection and balance. Fructooligosaccharides and steviol glycosides replace traditional sucrose to adjust the flavor. Psyllium husk and inulin supplement dietary fiber. Low-glycemic agents are suitable for people with high blood lipids and high blood sugar. Dietary fiber also promotes intestinal peristalsis. The overall formula balances health benefits, taste, and suitability for different populations.

[0037] The solid beverage features a core-shell double-layer composite granule structure. The core layer comprises a selenium-enriched liver-protecting active powder formulated with ingredients, seasonings, and dietary fiber. The outer shell layer forms a lipid-lowering flavor layer. The solid beverage is an effervescent formulation, incorporating food-grade citric acid, sodium bicarbonate, and plant-based buffers to create a natural acid-base effervescent system. It is also a individually dispensed form, with each sachet containing both instant and slow-release granules. Natural anti-caking agents, namely magnesium stearate and modified starch, are added. After premixing with additives and air-dispersion, the selenium content per gram of powder has an error of ≤5%. The formula is precisely pH-controlled to create an acid-base resistant system. The product utilizes core-shell double-layer composite granules and an effervescent formulation; the core layer carries the liver-protecting active ingredients, while the outer shell provides lipid-lowering and flavoring. The layered structure allows for easy identification of the active ingredients. The effervescent system features a controlled release rhythm for active ingredients, dissolves quickly, and is easy to prepare. Individually packaged in both instant and slow-release formulations, it allows for the phased release of active ingredients, extending the duration of action. The optimized dosage form design enhances the drinking experience, while the layered structure isolates different active substances, preventing interactions and maximizing the retention of lipid-lowering, liver-protecting, and selenium-supplementing activities. Suitable for convenient daily consumption, it incorporates magnesium stearate and modified starch as natural anti-caking agents to effectively prevent moisture absorption and clumping, ensuring granule flowability and brewing effect. Premixing with additives and airflow dispersion ensures highly uniform selenium distribution, preventing localized excessive or insufficient selenium levels. pH control creates an acid and alkali resistant system, ensuring product stability under different water qualities and storage conditions, minimizing deterioration of active ingredients, significantly extending shelf life, and guaranteeing long-term effectiveness.

[0038] A method for preparing a selenium-enriched lipid-lowering and liver-protecting solid beverage, the method comprising the following steps:

[0039] Step 1, Raw material pretreatment: Select all raw materials, and carry out solid-state pre-fermentation of selenium-enriched grains and herbal raw materials with compound probiotics. Then, use low-temperature airflow cell wall breaking combined with ultra-fine pulverization technology to pulverize the fermented raw materials.

[0040] Step 2, segmented temperature-controlled countercurrent extraction: Based on the dissolution characteristics of different components, a low-temperature segment is used to extract selenium and heat-sensitive liver-protecting components, and a medium-temperature segment is used to extract lipid-lowering flavonoids.

[0041] Step 3, Low-temperature concentration and freeze-drying: After the extract is concentrated using a vacuum low-temperature membrane, it is freeze-dried into powder, with the temperature not exceeding 50℃ throughout the process.

[0042] Step 4, double-layer microcapsule encapsulation: double-layer microcapsules are prepared using natural wall materials. The inner layer encapsulates selenium and fat-soluble liver-protecting active ingredients, while the outer layer encapsulates lipid-lowering flavonoids and a taste-masking carrier.

[0043] Step 5, gradient mixing: Mix the microcapsule powder, dietary fiber, and other ingredients in separate sections at low speeds in stages;

[0044] Step 6, Low-temperature non-thermal sterilization: The mixed materials are treated with low-temperature irradiation sterilization or pulsed light sterilization to obtain the finished selenium-enriched lipid-lowering and liver-protecting solid beverage.

[0045] This preparation method employs six core processes: raw material fermentation, segmented temperature-controlled extraction, low-temperature freeze-drying, double-layer encapsulation, gradient mixing, and low-temperature non-thermal sterilization. The entire process is designed to protect heat-sensitive active ingredients. Probiotic fermentation converts inorganic selenium into organic selenium, improving absorption efficiency; segmented extraction targets and dissolves different functional substances; low-temperature freeze-drying and non-thermal sterilization avoid high-temperature degradation of activity; and double-layer microcapsule encapsulation further locks in nutrients. The entire process is seamlessly integrated, improving raw material utilization while ensuring the core efficacy of the finished product in lowering lipids, protecting the liver, and supplementing selenium, making it suitable for large-scale industrial production.

[0046] In step one, the pre-fermentation process involves adding sterile water and 0.5%-1% glucose as a fermentation starter to the raw material components for compound probiotic fermentation. This compound probiotic fermentation results in a system of lactic acid bacteria and yeast. The small amount of inorganic selenium in the raw material components is converted into bound organic selenium. The plant cell walls are broken by low-temperature airflow, releasing the bound selenium and active ingredients within the cells. The particles are then pulverized to a particle size of 800-1200 mesh. Step one uses a compound probiotic pre-fermentation of lactic acid bacteria and yeast, with the addition of trace amounts of glucose to initiate fermentation. This process converts the selenite and other inorganic selenium in the raw materials into easily absorbed bound organic selenium, reducing selenium toxicity and improving bioavailability. Combined with low-temperature airflow cell breaking and ultra-fine pulverization, the plant cell walls are fully broken, releasing the internal selenium and functional components. The powder has a uniform particle size, dissolves faster during brewing, and leaves no residue. This entire pre-treatment process optimizes the quality of the raw materials from the source, laying a good foundation for subsequent extraction and granulation.

[0047] In step two, the temperature for extracting selenium in the low-temperature stage is controlled at ≤45℃, and the temperature for extracting heat-sensitive liver-protecting components is controlled at 35℃-45℃, with a countercurrent time of 1-2 hours in the low-temperature stage. In the medium-temperature stage, the temperature for extracting lipid-lowering flavonoids is controlled at 55℃-65℃, with a countercurrent time of 1-1.5 hours. Step two employs segmented temperature-controlled countercurrent extraction. The low-temperature stage (≤45℃) extracts selenium and heat-sensitive liver-protecting components, while the 35-45℃ range avoids the inactivation of active substances due to high temperatures. The 1-2 hour countercurrent extraction ensures sufficient extraction. The medium-temperature stage (55-65℃) specifically extracts lipid-lowering components such as hawthorn flavonoids and gypenosides, with an extraction time of 1-1.5 hours balancing efficiency and component integrity. This targeted extraction across temperature zones solves the problem of active ingredient loss caused by traditional one-pot extraction, ensuring optimal extraction rates for the three effective substances: lipid-lowering, liver-protecting, and selenium-supplementing, thus enhancing the overall health value of the product.

[0048] In step four, the natural wall material is one or a combination of maltodextrin, gum arabic, and resistant starch. In step five, the low-speed, zoned mixing process avoids frictional heating of the materials, and in step six, the sterilization process is heat-free, preserving all the functional active ingredients of the raw materials. Step four uses natural substances such as maltodextrin, gum arabic, and resistant starch as microcapsule wall materials. These natural wall materials are highly safe, have no chemical residues, and meet food-grade production standards. Different wall materials have differentiated encapsulation and sustained-release characteristics, and can be adapted to the characteristics of the inner layer (selenium, fat-soluble liver-protecting substances) and the outer layer (lipid-lowering flavonoids), effectively isolating the active ingredients from light, oxygen, and humidity. The wall material can mask the bitter odor of the herbal raw materials, improve the taste of the product, and achieve the dual function of preserving the activity and masking the taste. Step five involves low-speed step-by-step mixing in different zones, with the material temperature controlled throughout the process to prevent friction-induced heating and decomposition of active ingredients. Step six uses low-temperature non-thermal sterilization methods such as irradiation and pulsed light, which do not generate high temperatures or introduce chemical sterilizing agents, thus fully preserving all functional active substances in the raw materials, such as selenium, flavonoids, and lignans. The low-temperature process system runs through the mixing and sterilization stages, solving the defects of traditional high-temperature sterilization and high-speed mixing that lead to the loss of efficacy, ensuring the stable activity of each batch of finished products and strong consistency in product quality.

[0049] Example 2

[0050] Please see Figure 2-3 The present invention provides a technical solution:

[0051] I. Raw material ratio (parts by weight): 5.5 parts of selenium-enriched Cordyceps militaris were added to the ternary composite selenium source system. The overall formula was strictly configured according to the claims.

[0052] Junliao (a ternary compound selenium source, totaling 36.1 parts): 14 parts selenium-enriched kudzu root, 11 parts selenium-enriched wolfberry, 9 parts selenium-enriched cassia seed, 5.5 parts selenium-enriched broken-cell wall cordyceps militaris, 0.6 parts active yeast selenium, and 0.5 parts nano-chelated selenium.

[0053] Ingredients (23 portions): 10 portions of hawthorn, 6 portions of lotus leaf, and 7 portions of gynostemma pentaphyllum;

[0054] Seasonings (14 parts): 5 parts Schisandra chinensis, 4 parts Chrysanthemum morifolium, 3 parts Glycyrrhiza uralensis, 5 parts Raisin tree fruit;

[0055] Ingredients (8.4 parts): 8 parts fructooligosaccharides, 0.4 parts steviol glycosides;

[0056] Dietary fiber (11 servings): 6 servings of psyllium husk, 5 servings of inulin;

[0057] Excipients: Food-grade citric acid, sodium bicarbonate, plant-based buffer, magnesium stearate, and modified starch (appropriate amount).

[0058] The formula contains total saponins from Gynostemma pentaphyllum, hawthorn flavonoids, and schisandra lignans, which form a ternary synergistic active system.

[0059] II. Preparation Process

[0060] Raw material pretreatment: All selenium-enriched herbs and Cordyceps militaris raw materials are added with 0.8% glucose and sterile water, and then pre-fermented with a compound probiotic of lactic acid bacteria and yeast; subsequently, the cells are broken down by low-temperature airflow and ultra-finely pulverized to 1000 mesh.

[0061] Segmented temperature-controlled countercurrent extraction: low temperature segment (42℃, 1.5h) extracts selenium and liver-protecting heat-sensitive components; medium temperature segment (60℃, 1.2h) extracts hawthorn flavonoids, total saponins of Gynostemma pentaphyllum, and other lipid-lowering components.

[0062] Low-temperature concentration freeze-drying: The extract is concentrated in a vacuum low-temperature thin film and freeze-dried at ≤50℃ throughout the process to produce powder.

[0063] Double-layer microcapsule encapsulation: using maltodextrin and gum arabic as wall materials, the inner layer encapsulates selenium and fat-soluble liver-protecting components, while the outer layer encapsulates lipid-lowering flavonoids.

[0064] Gradient mixing: Mix all powders, dietary fiber and other ingredients in stages at low speed in separate zones to avoid friction and heating.

[0065] Forming and sterilization: Effervescent granules are made by adding effervescent agents and natural anti-caking agents, and are divided into two components: instant and slow-release. They are sterilized by pulsed light at low temperature and packaged into individually measured bags.

[0066] III. Mouse Animal Experiments

[0067] 1. Experimental animals: Sixty healthy male Kunming mice, weighing 20±2g, were selected and fed in a normal environment for 7 days with free access to water and food.

[0068] 2. Modeling Method: A mouse model of hyperlipidemia and liver damage was established by combining a high-fat diet and alcohol. The model was maintained for 4 weeks. Fifty mice with elevated blood lipids and abnormal liver function were selected and randomly divided into 5 groups of 10 mice each. Ten normal mice were used as a blank control group. Grouping Settings:

[0069] Blank control group: fed normally and administered an equal volume of physiological saline by gavage;

[0070] Model control group: After successful modeling, only an equal volume of physiological saline was administered orally, with no other intervention;

[0071] Low-dose experimental group: Daily oral administration of the solid beverage aqueous solution of this embodiment (0.5g / kg);

[0072] Medium-dose experimental group: Daily oral administration of the solid beverage aqueous solution of this embodiment (1.0 g / kg);

[0073] High-dose experimental group: Daily oral administration of the solid beverage aqueous solution of this embodiment (2.0 g / kg);

[0074] Positive drug control group: Daily oral administration of commercially available lipid-lowering and liver-protecting health drinks (1.0g / kg).

[0075] 3. Feeding and drug administration conditions: Mice in all groups were fed in the same environment and were administered gavage once a day for 4 consecutive weeks. During the experiment, the model group and all experimental groups were fed a high-fat diet, while the control group was fed a normal diet.

[0076] 4. Detection Indicators and Methods: After the experiment, mice were fasted for 12 hours, blood was collected from the orbital sinus, and liver tissue was obtained through dissection. Key indicators were detected.

[0077] Blood lipid indicators: total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C);

[0078] Liver function indicators: alanine aminotransferase (ALT), aspartate aminotransferase (AST);

[0079] Pathological observation of liver tissue: Staining of sections to observe fatty degeneration, inflammation, and damage of hepatocytes;

[0080] In vivo selenium content: The selenium content in mouse serum was measured.

[0081] 5. Experimental Conclusion: According to the appendix of the instruction manual... Figure 2 and 3 The test results show that:

[0082] The product in this embodiment can effectively reduce blood lipid levels in hyperlipidemic model mice, improve lipid metabolism, and has a significant lipid-lowering effect. The product can significantly reduce transaminase, repair liver damage induced by alcohol and hyperlipidemia, and has an outstanding liver-protecting effect. The ternary compound selenium source can stably supplement the body with selenium, and the selenium absorption and utilization rate is high. The total saponins of Gynostemma pentaphyllum, hawthorn flavonoids, and schisandra lignans work synergistically, and together with dietary fiber, they form a gut-liver linkage protection. The overall efficacy is superior to ordinary commercially available similar products, and no poisoning or adverse reactions were observed in mice at the experimental dose, indicating high safety.

[0083] The contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0084] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A selenium-enriched, lipid-lowering, and liver-protecting solid beverage, comprising raw material components, characterized in that: The raw material components are formulated according to the traditional Chinese medicine-food homology system, and the raw material components consist of principal ingredients, assistant ingredients, adjuvant ingredients, and guiding ingredients. The principal ingredient is 30-40 parts, which is a ternary compound selenium source, and the ternary compound selenium source is composed of organic plant selenium, active yeast selenium, and nano-chelated selenium. The organic plant selenium includes selenium-enriched kudzu root, selenium-enriched wolfberry, and selenium-enriched cassia seed. The assistant ingredients are 16-28 parts, which are hawthorn, lotus leaf, and gynostemma pentaphyllum. The adjuvant ingredients are 12-22 parts, which are schisandra, chrysanthemum, licorice, and jujube seed. The guiding ingredients are 8-18 parts, which are fructooligosaccharides and steviol glycosides. The solid beverage also contains 7-17 parts of dietary fiber, which is psyllium husk and inulin. The raw material components use total saponins of gynostemma pentaphyllum, hawthorn flavonoids, and schisandra lignans to form an active synergistic system.

2. The selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 1, characterized in that: The organic plant selenium contains 14 parts of selenium-enriched kudzu root, 11 parts of selenium-enriched wolfberry, and 9 parts of selenium-enriched cassia seed. The organic plant selenium also contains at least one of the following: selenium-enriched broken cell wall cordyceps, selenium-enriched golden camellia, fermented selenium-enriched black bean, and fermented dandelion, in 5.5 parts. The ternary composite selenium source contains 0.6 parts of active yeast selenium and 0.5 parts of nano-chelated selenium.

3. The selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 1, characterized in that: The ingredients include 10 parts hawthorn, 6 parts lotus leaf and 7 parts gynostemma pentaphyllum, and the seasonings include 5 parts schisandra, 4 parts chrysanthemum, 3 parts licorice and 5 parts jujube fruit. The seasonings include 8 parts fructooligosaccharides and 0.4 parts steviol glycosides. The dietary fiber includes 6 parts psyllium husk and 5 parts inulin.

4. The selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 1, characterized in that: The solid beverage has a core-shell double-layer composite particle structure. The core layer is composed of selenium-enriched liver-protecting active powder made from a formula of principal ingredients, secondary ingredients, seasonings, and dietary fiber. The outer shell is composed of a lipid-lowering flavor layer made from a formula of auxiliary ingredients. The solid beverage is an effervescent form, and food-grade citric acid, sodium bicarbonate, and plant buffers are added to the formula to form a natural acid-base effervescent system. The solid beverage is an independently dispensed dosage form, with each bag containing two components: instant granules and slow-release granules.

5. The selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 4, characterized in that: The solid beverage also contains natural anti-caking agents, namely magnesium stearate and modified starch. After the solid beverage is premixed with additives and dispersed by airflow, the selenium content per gram of powder has an error of ≤5%. The formula is precisely controlled by pH to form an acid and alkali resistant system.

6. A method for preparing a selenium-enriched lipid-lowering and liver-protecting solid beverage according to any one of claims 1-5, characterized in that: The preparation method includes the following steps: Step 1, Raw material pretreatment: Select all raw materials, and carry out solid-state pre-fermentation of selenium-enriched grains and herbal raw materials with compound probiotics. Then, use low-temperature airflow cell wall breaking combined with ultra-fine pulverization technology to pulverize the fermented raw materials. Step 2, segmented temperature-controlled countercurrent extraction: Based on the dissolution characteristics of different components, a low-temperature segment is used to extract selenium and heat-sensitive liver-protecting components, and a medium-temperature segment is used to extract lipid-lowering flavonoids. Step 3, Low-temperature concentration and freeze-drying: After the extract is concentrated using a vacuum low-temperature membrane, it is freeze-dried into powder, with the temperature not exceeding 50℃ throughout the process. Step 4, double-layer microcapsule encapsulation: double-layer microcapsules are prepared using natural wall materials. The inner layer encapsulates selenium and fat-soluble liver-protecting active ingredients, while the outer layer encapsulates lipid-lowering flavonoids and a taste-masking carrier. Step 5, gradient mixing: Mix the microcapsule powder, dietary fiber, and other ingredients in separate sections at low speeds in stages; Step 6, Low-temperature non-thermal sterilization: The mixed materials are treated with low-temperature irradiation sterilization or pulsed light sterilization to obtain the finished selenium-enriched lipid-lowering and liver-protecting solid beverage.

7. The preparation method of a selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 6, characterized in that: In step one, the pre-fermentation process involves adding sterile water and 0.5%-1% glucose as a fermentation starter carbon source to the raw material components, followed by compound probiotic fermentation. The compound probiotic fermentation results in a system of lactic acid bacteria and yeast. The small amount of inorganic selenium contained in the raw material components is converted into bound organic selenium raw material. The plant cell walls are broken by low-temperature airflow to release the bound selenium and active ingredients within the cells. The particles are then pulverized to a particle size of 800-1200 mesh.

8. The preparation method of a selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 6, characterized in that: In step two, the temperature for extracting selenium in the low-temperature stage is controlled at ≤45℃, and the temperature for extracting heat-sensitive liver-protecting components is controlled at 35℃-45℃, with a countercurrent time of 1-2 hours in the low-temperature stage; the temperature for extracting lipid-lowering flavonoids in the medium-temperature stage is controlled at 55℃-65℃, with a countercurrent time of 1-1.5 hours in the medium-temperature stage.

9. The preparation method of a selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 6, characterized in that: In step four, the natural wall material is one or more combinations of maltodextrin, gum arabic, and resistant starch.

10. The preparation method of a selenium-enriched lipid-lowering and liver-protecting solid beverage according to claim 6, characterized in that: The low-speed mixing process in step five avoids frictional heating of the materials, and the sterilization process in step six is ​​heat-free, preserving all functional active ingredients of the raw materials.

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