A traditional Chinese medicine composition for resisting radiation

Abstract

The present application relates to a kind of traditional Chinese medicine composition and its application of anti-radiation.It is prepared with effective component and pharmaceutically acceptable excipient into preparation, wherein effective component is prepared with the raw material medicine of following weight ratio: 8-12 parts of fuzilu, 8-12 parts of schisandra chinensis.The beneficial effects of the present application mainly reflect: formula is simple, raw material is cheap and easy to obtain and effect is remarkable, with good application prospect.

Description

Technical Field

[0001] This invention relates to a traditional Chinese medicine composition, specifically a traditional Chinese medicine composition for radiation protection. Background Technology

[0002] With the widespread use of radiation sources (such as nuclear technology, radiotherapy, and electronic products), radiation hazards have become a significant threat to human health. Chemical anti-radiation drugs are limited in application due to their high toxicity, while traditional Chinese medicine, through its principles of "strengthening the body's resistance and eliminating pathogens" and "treatment based on syndrome differentiation," has become a hot topic in anti-radiation research due to its advantages of low toxicity and multi-target effects.

[0003] The anti-radiation traditional Chinese medicine composition disclosed in CN116270830B uses "tonifying blood and qi, clearing heat and detoxifying" as its core treatment principle. Its core components include Angelica sinensis (24 parts), Glycyrrhiza uralensis (10 parts), Citrus reticulata peel (10 parts), Scutellaria baicalensis (10 parts), Platycladus orientalis leaf (12 parts), and Schisandra chinensis (6 parts). Its pharmacological mechanism is "supporting the body's resistance and eliminating pathogenic factors simultaneously": Angelica sinensis is the principal herb, nourishing blood and replenishing deficiency; Glycyrrhiza uralensis, Scutellaria baicalensis, and Platycladus orientalis leaf are the assistant herbs, tonifying qi and detoxifying; Citrus reticulata peel regulates qi and strengthens the spleen; and Schisandra chinensis astringes yin and generates fluids, acting as the guiding herb, collectively resisting "heat and toxic syndrome" caused by radiation. Experimental verification shows that this composition can significantly improve the survival rate of mice irradiated by X-rays. CN102319322B discloses a pharmaceutical composition for radiation damage to the reproductive system, with the core principle of "tonifying the kidneys, replenishing essence, and invigorating qi." The basic formulation contains wolfberry (90-150 parts), dodder seed (90-150 parts), cistanche (40-70 parts), raspberry (40-70 parts), and prepared rehmannia root (25-40 parts). The optimized formulation adds ginseng, yam, and plantain seed. The complete formulation (carnation granules) further adds deer antler (1.5-3 parts), poria, and angelica, totaling 20 kinds of traditional Chinese medicine. CN102948559A discloses a natural anti-radiation health tea for daily electromagnetic radiation protection. The ingredients are mainly based on "clearing heat and nourishing yin, strengthening the spleen and invigorating qi," including 14 kinds of medicinal materials such as wild chrysanthemum, cassia seed, licorice, poria, ginkgo, wolfberry, angelica, ophiopogon, schisandra, jujube, lotus seed, rose petals, lily, and cordyceps. This plan designs differentiated formulas for different body constitutions: the formula for men with a positive constitution contains 5% wild chrysanthemum, 4% cassia seed, and 4% cordyceps; the formula for women with a negative constitution contains 3% wild chrysanthemum, 5% cassia seed, and 5% cordyceps, aiming to reduce the effects of computer radiation on the skin and eyes (such as skin aging and vision damage) through daily consumption. CN107854565B discloses an anti-radiation traditional Chinese medicine composition with "tonifying qi and nourishing yin, benefiting essence and generating blood" as its core, the ingredients of which include angelica (2-15 parts), astragalus (10-70 parts), purslane (6-40 parts), poria (5-30 parts), hawthorn (3-20 parts), American ginseng (2-15 parts), wolfberry (4-25 parts), and white peony root (4-25 parts). The optimal formula is: 6 parts Angelica sinensis, 30 parts Astragalus membranaceus, 15 parts Portulaca oleracea, 12 parts Poria cocos, 7 parts Crataegus pinnatifida, 6 parts Panax quinquefolius, 10 parts Lycium barbarum, and 10 parts Paeonia lactiflora.

[0004] The aforementioned anti-radiation compositions are complex in composition, some containing precious medicinal materials such as deer antler, leading to difficulties in quality control (e.g., fluctuations in the content of deer antler velvet ketone), batch-to-batch consistency is hard to guarantee, and production costs are high. Therefore, obtaining a simple, high-quality, and effective anti-radiation traditional Chinese medicine composition is crucial. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine composition for radiation protection and its application.

[0006] The technical solution adopted in this invention is: an anti-radiation pharmaceutical composition, characterized in that: it is a preparation made from an active ingredient and pharmaceutically acceptable excipients, wherein the active ingredient is prepared from raw materials in the following weight ratio: 8-12 parts of Poria cocos and 8-12 parts of Schisandra chinensis; preferably 8-10 parts of Poria cocos and 10-12 parts of Schisandra chinensis; more preferably 10 parts of Poria cocos and 10 parts of Schisandra chinensis.

[0007] Poria cocos is a traditional Chinese medicine with diuretic, spleen-strengthening, and mind-calming effects. It is often used to improve edema, spleen deficiency, and insomnia. Schisandra chinensis is a relatively common Chinese herbal medicine with good effects for many people. Schisandra chinensis is sweet and sour in taste and warm in nature. It has the effects of tonifying the kidneys and calming the mind, replenishing qi and promoting body fluids, and consolidating the exterior and stopping sweating. It is often used for lung and kidney deficiency with asthma, internal heat and thirst, and can improve night sweats, palpitations, and insomnia.

[0008] The formula in this invention, composed of Poria cocos and Schisandra chinensis, has the effects of strengthening the spleen and kidneys, calming the mind and replenishing qi. Traditional Chinese medicine believes that the kidneys are the foundation of innate essence, storing essence, governing growth, development, and reproduction, and are the root of life. Essence is the material basis of human life activities. Sufficient kidney essence can be transformed into defensive qi through the process of "refining essence into qi." Defensive qi is an important defense against external pathogens, warming and nourishing the skin and pores, and resisting the invasion of external pathogens such as wind, cold, summer heat, dampness, dryness, and fire. If kidney essence is insufficient, the generation of defensive qi is inadequate, leading to restlessness, decreased immunity, and susceptibility to colds, infections, and other diseases. Furthermore, the kidneys govern the vaporization and transformation of body fluids, maintaining the body's fluid balance. Normal fluid metabolism helps with the circulation of qi and blood and the coordination of organ functions. If the kidneys' fluid metabolism function is abnormal, it may lead to internal retention of dampness or insufficient body fluids, affecting the generation and circulation of qi and blood, thereby weakening immunity. The spleen, considered the "foundation of acquired constitution," is the source of qi and blood production. It is responsible for transforming and transporting the essence of food and water into qi and blood, providing nutrition to the body, strengthening its vital energy, enhancing immunity, and helping to resist disease. The spleen's function relies on the warming and transforming effect of kidney yang, while kidney essence needs continuous replenishment through the spleen's transformation of food and water. Conversely, prolonged spleen deficiency can affect the kidneys, and kidney deficiency can also impair spleen function; the two are interdependent. Therefore, strengthening the spleen and kidneys, calming the mind and replenishing qi are often used to consolidate the foundation, support the body's resistance, and eliminate pathogens, thus preventing damage caused by radiation. In this formula, Poria cocos strengthens the spleen, calms the mind, and promotes diuresis; Schisandra chinensis tonifies the kidneys, calms the mind, replenishes qi, and generates fluids. The combination of these two herbs strengthens the spleen and kidneys, calms the mind, and replenishes qi, achieving the goal of "nourishing the innate constitution with acquired constitution" while calming the mind and replenishing qi, ensuring harmony between the heart and kidneys and smooth flow of qi and blood.

[0009] The formula of this invention is simple, the medicinal materials are cheap and readily available, and it has significant effects in anti-radiation. Detailed Implementation

[0010] The present invention will be further described below with reference to specific embodiments, but this is not intended to further limit the scope of protection of the present invention.

[0011] Example 1 Table 1 Pharmaceutical Compositions A 16 portions of Poria cocos B Schisandra chinensis 16 portions C0 Poria cocos (4 parts) + Schisandra chinensis (16 parts) C1 Poria cocos (8 parts) + Schisandra chinensis (12 parts) C2 Poria cocos (10 parts) + Schisandra chinensis (10 parts) C3 Poria cocos (12 parts) + Schisandra chinensis (8 parts) C4 Poria cocos (16 parts) + Schisandra chinensis (4 parts) According to the proportions of the drug composition in Table 1, add 10 times the amount of water to Poria cocos and Schisandra chinensis, decoct twice, 40 minutes each time, filter and combine, concentrate and dry to obtain the final product.

[0012] Example 2 Take 112 parts of wolfberry, 112 parts of dodder seed, 56 parts of cistanche, 56 parts of raspberry, 33.6 parts of prepared rehmannia root, 14 parts of ginseng, 14 parts of yam, 28 parts of plantain seed, 14 parts of schisandra fruit, 2.1 parts of deer antler, 8.4 parts of poria cocos, 8.4 parts of angelica sinensis, 8.4 parts of ophiopogon japonicus, 2.8 parts of phellodendron bark, 8.4 parts of achyranthes bidentata, 8.4 parts of eucommia ulmoides, 8.4 parts of cnidium monnieri, 8.4 parts of polygala tenuifolia, 8.4 parts of morinda officinalis, and 2.8 parts of licorice root. Soak in water for 4 hours, decoct twice, 2 hours each time, filter and combine, concentrate into a clear extract with a relative density of 1.34-1.40 (60-65℃). Add an appropriate amount of honey to the clear extract and dry under reduced pressure at 60℃ to obtain drug composition D.

[0013] Example 3 Wild chrysanthemum 3%, Cassia seed 5%, Poria cocos 5%, Ginkgo 6%, Schisandra chinensis 2%, Lycium barbarum 1%, Jujube 2%, Angelica sinensis 1%, Ophiopogon japonicus 1%, Lotus seed 5%, Rose petals 5%, Lily bulb 4%, Cordyceps sinensis 5%, Licorice 3%. The medicinal materials are pulverized, passed through a 20-40 mesh sieve, mixed evenly, and then combined with aloe vera extract and Auricularia auricula-judae extract to form a paste, thus obtaining drug composition E.

[0014] Example 4: [Regarding...] 60 Effects of Co irradiation on immune function in mice Establishment of a mouse immunosuppression model: administering immunosuppression to mice 60 Co irradiation with gamma rays, a single whole-body irradiation, to establish 60 A mouse immunosuppressive model was established by Co irradiation, with an irradiation dose of 4 Gy and a dose rate of 2.05 Gy / min.

[0015] Grouping and Dosing: Normal group: No modeling was performed; the same volume of distilled water was administered by gavage daily for 10 consecutive days. Model group: After modeling, the same volume of distilled water was administered by gavage daily for 10 consecutive days.

[0016] Each drug group was prepared according to the method in Table 1. The drug was dissolved thoroughly in 2 ml of distilled water. Mice were administered 2 ml of the drug solution once daily by gavage for 10 consecutive days. Except for the control group, all other groups of mice received the drug on the fourth day. 60Co-γ rays. The positive group was given LEUCOMAX (Gamma-ray Glucosamine) 1 μg subcutaneously.

[0017] One hour after the last administration, blood was collected from the eyeballs of mice, serum was separated, white blood cell count was measured, the mice were dissected, and the thymus and spleen were weighed and statistically analyzed.

[0018] Table 2 Drug Effects 60 Effects of Co irradiation on the immune organs thymus, spleen, and serum leukocyte markers in mice ( (n=10) normal group -- 128.33±13.20 38.59±5.01 16.59±5.01 Model group -- 96.09±12.78## 25.92±7.80## 8.55±4.01## positive group 1μg 124.07±11.03** 32.07±6.53** 15.55±5.53** A 0.0106g 105.46±9.68 30.06±6.01 9.60±4.87 B 0.0106g 105.06±8.34 30.16±4.33 9.98±4.65 C0 0.0134g 106.21±10.66 30.92±7.72 9.65±5.67 C1 0.0134g 124.33±9.85** 32.31±5.87** 15.21±4.83** C2 0.0134g 127.46±9.68*** 36.56±6.22*** 16.15±4.85*** C3 0.0134g 119.75±10.34* 32.06±4.36** 12.23±3.86* C4 0.0134g 106.29±14.55 30.97±7.95 9.78±6.24 D 0.0134g 124.42±9.67** 32.11±7.86** 15.18±7.64** E 0.0134g 123.33±10.85** 31.31±5.87** 15.25±5.23** Note: Comparison between the model group and the normal group. ##P<0.01 Compared with the model group, P>0.05, *P<0.05, **P< 0.01，***P<0.001 .

[0019] The results showed that, compared with the normal group, the levels of thymus, spleen, and serum leukocytes in the model group mice were significantly reduced. P< 0.01 This indicates successful model establishment; compared with the model group, the LEUCOMAX positive group significantly improved the levels of thymus and spleen and white blood cell count in the immune organs of mice affected by radiation exposure. P<0.01 Groups C1, D, and E significantly improved the levels of immune organ markers (thymus and spleen) and white blood cell count in mice affected by radiation exposure. P<0.01 C2 significantly improved the effects of radiation exposure on the levels of immune organs such as the thymus and spleen, and white blood cell count in mice. P<0.001 Group C3 significantly improved the effects of radiation exposure on the thymus and white blood cell count in mice. P<0.05 Significantly improved the effects of radiation exposure on spleen markers, an immune organ in mice. P<0.01 Groups A, B, C0, and C4 did not significantly improve the effects of radiation exposure on the levels of immune organs such as the thymus and spleen, and white blood cell count in mice. P>0.05 ).

[0020] Example 5 (1) To 60 Effects of Co irradiation on immune function in mice The same method as in Case 1 was used to establish a model and administer high, medium, and low doses of drug C2, observing the effects of different doses on... 60 Effects of Co irradiation on the immune function of mice. The positive group was given LEUCOMAX (GM-CSF) by subcutaneous injection of 1 μg.

[0021] Table 3 Drug Effects 60 Effects of Co irradiation on the immune organs thymus, spleen, and serum leukocyte markers in mice ( (n=10) normal group -- 138.33±12.51 46.56±6.33 17.81±5.64 Model group -- 104.33±12.52## 27.88±7.76## 9.99±5.58## positive group 1μg 137.27±12.10*** 43.43±6.83*** 16.68±6.64*** C2 high dose 0.0268g 137.54±9.91*** 43.57±7.98*** 16.05±7.03*** C2 medium dose 0.0134g 129.35±8.74** 40.34±6.51** 15.10±5.75** C2 low dose 0.0067g 124.12±9.47* 34.21±9.72* 14.56±7.32* Note: Comparison between the model group and the normal group. ##P<0.01 Compared with the model group, *P<0.05, **P<0.01, ***P< 0.001 .

[0022] The results showed that, compared with the normal group, the levels of thymus, spleen, and serum leukocytes in the model group mice were significantly reduced. P< 0.01 This indicates successful model establishment; compared with the model group, the LEUCOMAX positive group significantly improved the levels of thymus and spleen and white blood cell count in the immune organs of mice affected by radiation exposure. P<0.001 Group C2 significantly improved the levels of thymus and spleen markers and white blood cell count in mice affected by radiation exposure, with a certain dose-dependent effect. High doses showed a highly significant improvement in the levels of thymus and spleen markers and white blood cell count in mice affected by radiation exposure. P<0.001 ).

[0023] (2) Effects on immune function of rats after a single whole-body X-ray irradiation Establishment of a rat model of immunosuppression by a single whole-body irradiation with X-rays: A rat model of immunosuppression by X-ray irradiation was established by administering a single whole-body irradiation with an irradiation dose of 5 Gy and a dose rate of 1 Gy / min.

[0024] Grouping and Dosing: Normal group: No modeling was performed; the same volume of distilled water was administered by gavage daily for 10 consecutive days. Model group: After modeling, the same volume of distilled water was administered by gavage daily for 10 consecutive days.

[0025] Rats were administered C2 high, medium, and low doses of the drug once daily by gavage for 10 consecutive days. Except for the normal group, all other groups of rats were exposed to X-rays on day 7. The positive group was LEUCOMAX (Gastrointestinal Glucosamine GM-CSF).

[0026] One hour after the last administration, blood was collected from the rats' eyeballs, serum was separated, white blood cell count was measured, the rats were dissected, and their thymus and spleen were weighed and statistically analyzed.

[0027] Table 4. Effects of the drug on the immune organs thymus, spleen, and serum leukocyte indicators in rats irradiated by X-rays ( (n=10) normal group -- 1381.21±120.33 491.89±90.67 170.89±50.88 Model group -- 1115.33±123.54## 278.75±90.78## 90.65±70.59## positive group 5μg 1137.43±112.34*** 438.43±60.83*** 160.74±60.89*** C2 high dose 0.134g 1137.56±90.87*** 433.63±70.03*** 160.65±70.11*** C2 medium dose 0.067g 1149.05±80.76** 400.36±60.43** 150.17±50.54** C2 low dose 0.033g 1124.43±90.44* 340.91±90.65* 140.82±70.44* Note: Comparison between the model group and the normal group. ##P<0.01 Compared with the model group, *P<0.05, **P<0.01, ***P< 0.001 .

[0028] The results showed that, compared with the normal group, the levels of thymus, spleen, and serum leukocytes in rats in the X-ray single whole-body irradiation immune function model group were significantly reduced.P<0.01 This indicates successful model establishment; compared with the model group, the LEUCOMAX positive group significantly improved the levels of the thymus and spleen, and the white blood cell count, in rats after a single whole-body X-ray irradiation. P<0.001 Group C2 significantly improved the levels of thymus and spleen markers and white blood cell count in rats after a single whole-body X-ray irradiation, with a certain dose-dependent effect. High doses showed extremely significant improvement in the levels of thymus and spleen markers and white blood cell count in rats after a single whole-body X-ray irradiation. P<0.001 ).

Claims

1. A radiation-resistant pharmaceutical composition, characterized in that: It is a preparation made from active ingredients and pharmaceutically acceptable excipients, wherein the active ingredients are prepared from raw materials in the following weight ratio: Poria cocos 8-12 parts and Schisandra chinensis 8-12 parts.

2. The anti-radiation pharmaceutical composition according to claim 1, characterized in that, The active ingredients are prepared from raw materials in the following weight ratio: 8-10 parts of Poria cocos and 10-12 parts of Schisandra chinensis.

3. The anti-radiation pharmaceutical composition according to claim 1, characterized in that, The active ingredients are prepared from raw materials in the following weight ratio: 10 parts Poria cocos and 10 parts Schisandra chinensis.

4. A method for extracting the traditional Chinese medicine composition according to any one of claims 1-3, the method comprising: Mix and grind Poria cocos and Schisandra chinensis, add 10 times the amount of water, decoct twice, 40 minutes each time, filter and combine, concentrate and dry to obtain the final product.

5. The use of the traditional Chinese medicine composition as described in any one of claims 1-4 in the preparation of an anti-radiation drug.