A traditional Chinese medicine composition for treating eczema and dermatitis and a preparation method and use thereof

Abstract

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating eczema and dermatitis skin diseases and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from raw medicinal materials of Coptis chinensis, Phellodendri chinensis, Angelica sinensis, Evodia rutaecarpa, Curcuma longa, Sanguisorba officinalis, Glycyrrhiza uralensis, Rehmannia glutinosa, Xanthium sibiricum, and Rhus succedaneum, and has the effects of clearing heat and drying dampness, detoxifying and removing blood stasis, counteracting and warming yang, and astringing and relieving itching. The traditional Chinese medicine composition of the present application adds the idea of counteracting and warming yang on the basis of conventional clearing damp-heat, avoids the condition of ice accumulation of damp pathogens caused by pure cold drugs, and is particularly suitable for complex conditions of eczema and dermatitis of damp-heat type, such as delayed recovery, repeated skin lesions, severe itching, and poor effect of long-term use of cold external medicines. Therefore, the traditional Chinese medicine composition of the present application has important clinical significance and broad market application prospect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically a traditional Chinese medicine composition for treating eczema and dermatitis, its preparation method, and its uses. Background Technology

[0002] Eczema is one of the most prevalent chronic inflammatory skin diseases in clinical practice, with damp-heat type eczema accounting for over 60% of adult chronic eczema patients. Current conventional Western medicine treatments often involve interventions such as corticosteroids, antihistamines, and calcineurin inhibitors. While these can quickly relieve acute erythema and itching symptoms, long-term use can easily lead to adverse reactions such as skin atrophy, pigmentation, and increased drug resistance. The relapse rate after discontinuation of medication remains consistently high. For patients with persistent eczema lasting more than 6 months, the long-term control rate of single-treatment Western medicine is less than 30%. Many patients, due to intolerance to the side effects of Western medicine, turn to traditional Chinese medicine (TCM) treatment. These patients often present with recurrent exudation, severe itching, and a prolonged, difficult-to-cure course. Some patients, after prolonged use of cold-natured topical medications, are prone to developing dampness and stagnation, resulting in thickened and persistent skin lesions. Existing clinical treatments have significant limitations.

[0003] Current TCM treatments for eczema primarily focus on clearing heat and dampness, dispelling wind and relieving itching. Commonly used formulas often incorporate bitter and cold herbs such as Coptis chinensis and Phellodendron amurense. While these can alleviate acute redness and oozing symptoms in the short term, long-term, high-dose use of purely cold herbs can damage the local skin's Yang energy, leading to dampness stagnation and blockage deep within the skin, thus prolonging the course of the disease. This is especially true for complex, persistent eczema patients who have not responded well to long-term use of cold topical medications; the effectiveness rate of conventional treatments is less than 45%. Furthermore, existing publicly available TCM formulas for eczema generally lack antagonistic warming and invigorating combinations, failing to address the underlying Yang deficiency in damp-heat syndromes and thus failing to resolve the clinical challenge of lurking dampness.

[0004] Further analysis of existing publicly available Chinese herbal formulas for eczema reveals that most formulas focus solely on the single function of clearing heat and drying dampness, exhibiting severe homogenization in their formulations and a general lack of warming and invigorating herbs. This fails to break the pathological cycle of damp-heat stagnation and stasis. For stubborn eczema with thickened skin lesions and recurrent exudation, long-term use can easily lead to adverse reactions such as cold skin lesions, difficulty in stopping exudation, and recurrent itching, significantly reducing the effectiveness in actual clinical applications.

[0005] To address the shortcomings of existing technologies, this invention proposes a novel approach to the formulation of traditional Chinese medicine compositions. Building upon conventional methods for clearing heat and dampness, it innovatively incorporates a counteracting and warming principle. It selects Coptis chinensis and Phellodendron chinense to clear heat and dry dampness, Angelica sinensis and Curcuma longa to detoxify and disperse blood stasis, and Evodia rutaecarpa to counteract and invigorate Yang. Combined with Sanguisorba officinalis, Polygonum aviculare, Cynanchum paniculatum, Smilax glabra, Galla chinensis, and Glycyrrhiza uralensis for synergistic effects, this approach retains the advantages of traditional Chinese medicine in clearing heat and relieving itching while avoiding the problem of dampness accumulating due to purely cold-natured herbs. This provides a novel technical pathway for treating persistent damp-heat type eczema. Summary of the Invention

[0006] The present invention aims to overcome the shortcomings of the prior art and solve the following core technical problems: how to provide a traditional Chinese medicine composition for treating eczema and dermatitis-like skin diseases (especially atopic dermatitis, seborrheic dermatitis, and neurodermatitis), as well as its preparation method and uses.

[0007] Specifically, the present invention is achieved through the following technical solutions: In a first aspect, the present invention provides a traditional Chinese medicine composition for treating eczema and dermatitis-like skin diseases, the traditional Chinese medicine composition being made from the following raw materials in parts by weight: 10-30 parts of Phellodendron bark, 5-25 parts of Curcuma longa, 5-25 parts of Sanguisorba officinalis, 10-30 parts of Polygonum multiflorum, 10-30 parts of Smilax glabra, 1-20 parts of Angelica sinensis, 1-10 parts of Evodia rutaecarpa, 5-25 parts of Cynanchum paniculatum, 1-20 parts of Galla chinensis, and 1-20 parts of Glycyrrhiza uralensis.

[0008] Alternatively, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 15-25 parts of Phellodendron bark, 10-20 parts of Curcuma longa, 10-20 parts of Sanguisorba officinalis, 15-25 parts of Polygonum multiflorum, 15-25 parts of Smilax glabra, 5-15 parts of Angelica sinensis, 1-5 parts of Evodia rutaecarpa, 10-20 parts of Cynanchum paniculatum, 5-15 parts of Galla chinensis, and 5-15 parts of Glycyrrhiza uralensis.

[0009] As an optional method, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 20 parts of Phellodendron bark, 15 parts of Curcuma longa, 15 parts of Sanguisorba officinalis, 20 parts of Polygonum multiflorum, 20 parts of Smilax glabra, 10 parts of Angelica sinensis, 3 parts of Evodia rutaecarpa, 15 parts of Cynanchum paniculatum, 10 parts of Galla chinensis, and 10 parts of Glycyrrhiza uralensis.

[0010] Alternatively, in the above-mentioned traditional Chinese medicine composition, the traditional Chinese medicine composition has the effects of clearing heat and drying dampness, detoxifying and dispersing blood stasis, counteracting and promoting yang, and astringing sores and relieving itching.

[0011] In a second aspect, the present invention provides a method for preparing the traditional Chinese medicine composition described in the first aspect above, the method comprising the following steps: weighing each raw material in the weight proportions described in the first aspect above, pre-treatment, extraction, and concentration.

[0012] Preferably, in the above preparation method, the traditional Chinese medicine composition of the present invention can be prepared using conventional methods known in the art.

[0013] Preferably, the extraction methods used in this invention include, but are not limited to, decoction extraction, reflux extraction, ultrasonic extraction, and supercritical extraction.

[0014] Preferably, water, commonly used organic solvents in the art, or mixtures thereof can be used to extract the treated active pharmaceutical ingredient.

[0015] Preferably, the organic solvent is methanol, ethanol, propanol, butanol, ethyl acetate, petroleum ether, etc.

[0016] Preferably, the process includes weighing each raw material, pulverizing, extracting, and concentrating.

[0017] Preferably, the extraction method is decoction, and / or the extraction solvent is water or ethanol, and / or the number of decoctions is 1-3, and / or the decoction time for each decoction is 1-3 hours.

[0018] Preferably, water extraction is used (e.g., decoction with water).

[0019] Preferably, the preparation method of the traditional Chinese medicine composition of the present invention includes the following steps: weighing each raw material according to the weight proportions described in the first aspect above, mixing them, soaking them in water for 30-60 minutes, with the amount of water being 8-12 times the total weight of the medicinal materials. First decoction for 1.5-2 hours, filtering to obtain the juice; then adding 6-8 times the amount of water to the dregs, decocting for 1-1.5 hours, and filtering. Combining the two filtrates to prepare a concentrated traditional Chinese medicine paste.

[0020] In a third aspect, the present invention provides the use of the traditional Chinese medicine composition described in the first aspect above, or the traditional Chinese medicine composition prepared by the preparation method described in the second aspect above, in the preparation of a medicament for treating eczema and dermatitis-like skin diseases.

[0021] Alternatively, in the above-described uses, the drug is used to treat damp-heat type dermatitis and eczema.

[0022] Alternatively, in the above-described uses, the dermatitis-related skin disease is atopic dermatitis, seborrheic dermatitis, or neurodermatitis.

[0023] Alternatively, in the above-described uses, the drug may be an oral dosage form or a topical dosage form.

[0024] Alternatively, in the above-mentioned uses, the medicine may be a decoction, powder, oral liquid, ointment, granule, tablet, capsule, wash, ointment, plaster, tincture, or varnish.

[0025] Compared with the prior art, the present invention has the following beneficial effects: The herbal composition of this invention possesses the effects of clearing heat and drying dampness, detoxifying and dispersing blood stasis, counteracting and invigorating yang, and astringing sores and relieving itching. This herbal composition, based on conventional methods of clearing heat and dampness, incorporates counteracting and warming principles, avoiding the situation where purely cold herbs can cause dampness to linger. It is particularly suitable for complex cases of damp-heat type dermatitis and eczema that are persistent, with recurring skin lesions, severe itching, and poor response to prolonged use of cold external medications. Therefore, the herbal composition of this invention has significant clinical value and broad market application prospects. Detailed Implementation

[0026] The traditional Chinese medicine composition of this invention is made from raw materials including Coptis chinensis, Phellodendron chinense, Angelica sinensis, Evodia rutaecarpa, Curcuma longa, Sanguisorba officinalis, Glycyrrhiza uralensis, Polygonum multiflorum, Cynanchum paniculatum, Smilax glabra, and Galla chinensis.

[0027] The core treatment principle of the traditional Chinese medicine composition of this invention is to clear heat and dry dampness, detoxify and disperse blood stasis, counteract and promote yang, and astringe sores and relieve itching. It adds the idea of ​​counteracting and warming on the basis of conventional clearing heat and dampness, avoiding the dampness from being trapped by pure cold medicine. It is especially suitable for complex situations of damp-heat type dermatitis and eczema that are difficult to cure, with repeated exudation of skin lesions, severe itching, and poor effect of long-term use of cold external medicines.

[0028] The compatibility mechanism and formulation explanation of the traditional Chinese medicine composition of this invention are as follows: 1. Principal herbs: Coptis chinensis, Phellodendron chinense Both herbs are bitter and cold, directly clearing damp-heat from the upper and lower burners, directly targeting the core pathogenesis of dermatitis and eczema caused by damp-heat invasion, and quickly eliminating the core lesions of erythema, swelling, and exudation, which is the core support for the efficacy of the whole formula.

[0029] 2. Assistant herbs: Curcuma longa, Sanguisorba officinalis, Polygonum multiflorum, Smilax glabra Turmeric breaks up blood stasis and promotes qi circulation, guiding damp heat to dissipate from the blood; Sanguisorba officinalis cools the blood and astringes, quickly reducing wound exudation; Polygonum multiflorum promotes diuresis and relieves itching, directly acting on the local skin lesions to alleviate redness, swelling and itching; Smilax glabra deeply searches for hidden damp toxins, solving the problem of recurrent chronic eczema. The four herbs work together to assist the principal herb in strengthening the efficacy of clearing heat, drying dampness, detoxifying and dispersing blood stasis.

[0030] 3. Adjuvant herbs: Angelica sinensis, Evodia rutaecarpa, Cynanchum paniculatum, Gallnut Angelica sinensis nourishes and invigorates the blood, avoiding the depletion of yin and blood by large amounts of bitter and cold herbs, while improving local microcirculation in the skin lesions; a small amount of Evodia rutaecarpa is added to counteract the bitter and cold nature of the whole formula with its pungent and hot properties, preventing cold stagnation and dampness from becoming difficult to disperse, while also guiding the medicine into the skin and pores, alleviating the problem of local skin lesions feeling cold and slow to heal in some patients due to long-term external use of cold medicines; Cynanchum paniculatum dispels wind and relieves itching, specifically targeting the migratory and paroxysmal severe itching of eczema, relieving the itching caused by wind evil; Gallnut astringes sores and removes dampness, promoting the rapid healing of eroded and ulcerated skin lesions, while preventing excessive leakage of damp toxins and depletion of vital energy.

[0031] 4. Medicinal herb: Licorice It harmonizes the properties of all the herbs in the formula, moderates the bitter and cold irritation of Coptis chinensis and Phellodendron chinense, and also controls the pungent, hot and dry properties of Evodia rutaecarpa, guiding all the herbs to act precisely on the affected skin area.

[0032] In the pharmaceutical applications described above, the timing, frequency, and duration of administration of the traditional Chinese medicine composition and other active ingredients need to be determined based on the specific diagnostic results of the patient's condition, which is within the technical scope of those skilled in the art. For example, when applying a treatment regimen for mice or rats to humans, the effective dose of all drugs for humans can be converted from the effective dose of the drug for mice or rats, which is easily achievable by those skilled in the art.

[0033] The present invention will be further described below with reference to specific embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of the invention.

[0034] Where specific techniques or conditions are not specified in the examples, they shall be performed in accordance with the techniques or conditions described in the literature in this field, or in accordance with the product instructions. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased through legitimate channels.

[0035] Unless otherwise specified, the experimental methods used in the following embodiments are conventional methods. Unless otherwise specified, the experimental materials used in the following embodiments are commercially available products.

[0036] Unless otherwise stated, all percentages and parts in this invention refer to weight percentages and weight parts.

[0037] Preparation Example: Example 1: A traditional Chinese medicine composition for treating eczema and dermatitis-like skin diseases, the composition being made from the following raw materials: 20 parts of Phellodendron bark, 15 parts of Curcuma longa, 15 parts of Sanguisorba officinalis, 20 parts of Polygonum multiflorum, 20 parts of Smilax glabra, 10 parts of Angelica sinensis, 3 parts of Evodia rutaecarpa, 15 parts of Cynanchum paniculatum, 10 parts of Galla chinensis, and 10 parts of Glycyrrhiza uralensis.

[0038] The preparation method of the traditional Chinese medicine composition includes the following steps: Mix the above 10 medicinal materials, soak them in water for 30 minutes (the amount of water is 8 times the total weight of the medicinal materials), decoct for 2 hours initially, filter to obtain the juice; add 6 times the amount of water to the dregs, decoct for about 1 hour, and filter again. Combine the two filtrates to prepare a concentrated traditional Chinese medicine paste with a relative density of 1.2 ± 0.05 (60℃), vacuum seal it, and store it in a refrigerator at 4℃ for later use.

[0039] Comparative Example 1: A traditional Chinese medicine composition, said composition being made from the following raw materials: 20 parts of Phellodendron bark, 15 parts of Curcuma longa, 15 parts of Sanguisorba officinalis, 20 parts of Smilax glabra, 10 parts of Angelica sinensis, 3 parts of Evodia rutaecarpa, 35 parts of Cynanchum paniculatum, 10 parts of Galla chinensis, and 10 parts of Glycyrrhiza uralensis.

[0040] The preparation method of the traditional Chinese medicine composition is the same as in Example 1.

[0041] Comparative Example 2: A traditional Chinese medicine composition, said composition being made from the following raw materials: 20 parts of Phellodendron bark, 15 parts of Curcuma longa, 15 parts of Sanguisorba officinalis, 20 parts of Polygonum multiflorum, 20 parts of Smilax glabra, 10 parts of Angelica sinensis, 13 parts of Evodia rutaecarpa, 5 parts of Cynanchum paniculatum, 10 parts of Galla chinensis, and 10 parts of Glycyrrhiza uralensis.

[0042] Example of effect: Example of effect 1: The effect of the traditional Chinese medicine composition of the present invention on a mouse model of acute eczema. This experiment selected concentrated herbal extracts with a relative density of 1.2 ± 0.05 (60℃) prepared in Examples 1, 1, and 2, diluted 10 times with purified water, and compared their efficacy against acute eczema using the same dosage of raw herbs. Meanwhile, the commercially available antihistamine loratadine was used as a positive control. The extracts were dissolved in 0.5% sodium carboxymethyl cellulose (1 mg / mL concentration) and administered at 10 mg / kg per dose to verify the therapeutic effect of the herbal composition of this invention on acute contact eczema.

[0043] 1. Test Protocol Fifty-four SPF-grade male ICR mice, weighing 18-22g, were randomly divided into six groups of nine mice each: blank control group, model control group, Example 1 group, comparative example 1 group, comparative example 2 group, and positive control group.

[0044] One day prior to the experiment, a 2 cm × 2 cm area on the back of mice was shaved. Except for the blank control group, mice in all other groups underwent initial sensitization by uniformly applying 100 μL of 7% (w / v, g / 100 mL) 2,4-dinitrochlorobenzene (DNCB) sensitization solution (acetone:soybean oil = 4:1, v / v) to the shaved area. Five days later, mice underwent a second challenge by applying 10 μL of 1% DNCB (w / v, g / 100 mL) challenge solution (acetone:soybean oil = 4:1, v / v) to the inner side of the right ear, and an equal amount of blank matrix was applied to the inner side of the left ear. Mice in the blank control group underwent equal amounts of blank matrix applied to the inner sides of both ears. Twenty-four hours after challenge, groups 1 (Example 1), 1 (Comparative Example 1), and 2 (Comparative Example 2) began daily gavage administration of 0.2 mL for 7 consecutive days. The positive control group also received daily gavage administration of 10 mg / kg for 7 consecutive days. Relevant indicators were measured one hour after the last administration.

[0045] Statistical analysis was performed using SPSS v21.0 (SPSS, USA). Data are expressed as mean ± standard deviation. The Shapiro-Wilk method was used for normality testing, and independent samples t-tests were used for comparisons between two groups. P < 0.05 was considered statistically significant.

[0046] 2. Experimental Results The experimental results (see Table 1) showed that after stimulation, the right ear of the model group mice showed obvious redness and swelling, and the number of scratchings was significantly higher than that of the blank control group, indicating that the acute eczema model was successfully established.

[0047] In Example 1, the number of itching episodes in mice decreased by 56.6% compared to the model group, and ear weight decreased by 36.9% compared to the model group. Both indicators were significantly better than those in the model group. The effect of inhibiting ear swelling was significantly better than that in the loratadine positive control group, and also better than that in Comparative Example 1, which lacked Polygonum multiflorum, and Comparative Example 2, which had a higher dosage of Evodia rutaecarpa. This proves that the specific combination of traditional Chinese medicine in this invention can simultaneously achieve the dual effects of rapid itch relief and anti-inflammatory and swelling reduction. The overall therapeutic effect on acute eczema is significantly better than that in the comparative example group with similar medicinal ingredients and the conventional antihistamine group.

[0048] Table 1 Comparison of the number of itching episodes and right ear weight in mice with acute eczema in each group ( ±s, n=9) Note: Compared with the blank control group This indicates that P < 0.01. This indicates that P < 0.001; compared with the model control group, # This indicates that P < 0.05. ## This indicates that P < 0.01.

[0049] Example 2: Effect of the herbal composition of the present invention on a mouse model of chronic eczema This experiment selected concentrated herbal extracts with a relative density of 1.2±0.05 (60℃) prepared in Examples 1, 1, and 2, diluted 10 times with purified water, and compared their efficacy against chronic eczema using the same dosage of raw herbs. Meanwhile, the commercially available antihistamine loratadine was used as a positive control. The extracts were dissolved in 0.5% sodium carboxymethyl cellulose (1 mg / mL concentration) and administered at 10 mg / kg per dose to verify the therapeutic effect of the herbal composition of this invention on chronic recurrent eczema.

[0050] 1. Test Protocol Fifty-four SPF-grade male ICR mice, weighing 18-22g, were randomly divided into six groups of nine mice each: blank control group, model control group, Example 1 group, comparative example 1 group, comparative example 2 group, and positive control group.

[0051] One day prior to the experiment, a 2 cm × 2 cm area on the back of mice was shaving. Except for the blank control group, all other groups of mice underwent initial sensitization by uniformly applying 100 μL of 7% (w / v, g / 100 mL) 2,4-dinitrochlorobenzene (DNCB) sensitization solution (acetone:soybean oil = 4:1, v / v) to the shaving area. Starting from day 5, every 3 days, 10 μL of 1% DNCB (w / v, g / 100 mL) challenge solution (acetone:soybean oil = 4:1, v / v) was applied to the inner side of the right ear of each mouse for a total of 6 challenges, establishing a chronic recurrent eczema model. An equal amount of blank matrix was applied to the inner side of the left ear; mice in the blank control group had an equal amount of blank matrix applied to the inner sides of both ears. Twenty-four hours after the last challenge, the Example 1 group, Comparative Example 1 group, and Comparative Example 2 group began to receive the drug once a day by gavage, 0.2 mL each time, for 20 consecutive days. The positive drug group also received the drug once a day by gavage, 10 mg / kg each time, for 20 consecutive days. Relevant indicators were tested one hour after the last administration.

[0052] Statistical analysis was performed using SPSS v21.0 (SPSS, USA). Data are expressed as mean ± standard deviation. The Shapiro-Wilk method was used for normality testing, and independent samples t-tests were used for comparisons between two groups. P < 0.05 was considered statistically significant.

[0053] 2. Experimental Results The experimental results (see Table 2) showed that after repeated stimulation, the right ear of the model group mice showed obvious redness and thickening, and the number of scratching due to itching was significantly higher than that of the blank control group, indicating that the chronic recurrent eczema model was successfully established.

[0054] In Example 1, the number of itching episodes in mice decreased by 61.5% compared to the model group, ear weight decreased by 40.1%, and ear thickness decreased by 46.2%, all three indicators being significantly better than the model group. Among them, the inhibition effect on ear swelling (including ear weight and ear thickness) was significantly better than that of the loratadine positive control group, and also better than that of the control group 1 which lacked Polygonum cuspidatum and the control group 2 which had a higher dosage of Evodia rutaecarpa. This proves that the specific combination of traditional Chinese medicine in this invention can simultaneously achieve the dual effects of long-term antipruritic and anti-inflammatory and swelling-reducing effects, and the overall therapeutic effect on chronic recurrent eczema is significantly better than that of the control group with similar medicinal ingredients and the conventional antihistamine group.

[0055] Table 2 Comparison of itching frequency, right ear weight, and right ear thickness in mice with chronic eczema in each group ( ±s, n=9) Note: Compared with the blank control group This indicates that P < 0.01. This indicates that P < 0.001; compared with the model control group,# This indicates that P < 0.05. ## This indicates that P < 0.01.

[0056] The experimental results also showed (see Table 3) that the ear tissue of mice in the chronic eczema model group showed obvious epidermal thickening, and the serum inflammatory factor IL-1β and the total IgE level of allergy index were significantly increased, indicating that the chronic recurrent eczema model was successfully established.

[0057] Compared with the model group, the Example 1 group could downregulate the serum IL-1β level of mice with chronic eczema by 53.9% and the serum total IgE level by 55.3%. Its effect in inhibiting chronic inflammatory infiltration and anti-allergy was significantly better than loratadine and other comparative groups. This proves that the specific combination of traditional Chinese medicine in this invention achieves multiple effects of relieving itching, anti-inflammation and regulating immune imbalance through multi-target synergistic action, and has made significant progress in the overall treatment of chronic eczema.

[0058] Table 3 Comparison of inflammatory factor indices in mice with chronic eczema in each group ( ±s, n=9) Note: Compared with the blank control group This indicates that P < 0.01. This indicates that P < 0.001; compared with the model control group, # This indicates that P < 0.05. ## This indicates that P < 0.01.

[0059] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A traditional Chinese medicine composition for treating eczema and dermatitis-like skin diseases, characterized in that: The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 10-30 parts of Phellodendron bark, 5-25 parts of Curcuma longa, 5-25 parts of Sanguisorba officinalis, 10-30 parts of Polygonum multiflorum, 10-30 parts of Smilax glabra, 1-20 parts of Angelica sinensis, 1-10 parts of Evodia rutaecarpa, 5-25 parts of Cynanchum paniculatum, 1-20 parts of Galla chinensis, and 1-20 parts of Glycyrrhiza uralensis.

2. The traditional Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 15-25 parts of Phellodendron bark, 10-20 parts of Curcuma longa, 10-20 parts of Sanguisorba officinalis, 15-25 parts of Polygonum multiflorum, 15-25 parts of Smilax glabra, 5-15 parts of Angelica sinensis, 1-5 parts of Evodia rutaecarpa, 10-20 parts of Cynanchum paniculatum, 5-15 parts of Galla chinensis, and 5-15 parts of Glycyrrhiza uralensis.

3. The traditional Chinese medicine composition according to claim 2, characterized in that: The traditional Chinese medicine composition is made from the following raw materials in parts by weight: 20 parts of Phellodendron bark, 15 parts of Curcuma longa, 15 parts of Sanguisorba officinalis, 20 parts of Polygonum multiflorum, 20 parts of Smilax glabra, 10 parts of Angelica sinensis, 3 parts of Evodia rutaecarpa, 15 parts of Cynanchum paniculatum, 10 parts of Galla chinensis, and 10 parts of Glycyrrhiza uralensis.

4. The traditional Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition has the effects of clearing heat and drying dampness, detoxifying and dispersing blood stasis, counteracting and promoting yang, and astringing sores and relieving itching.

5. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The preparation method includes the following steps: weighing each raw material according to the weight proportions of any one of claims 1 to 4, pre-treating, extracting, and concentrating.

6. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4, or the traditional Chinese medicine composition prepared by the preparation method according to claim 5, in the preparation of a medicament for treating eczema and dermatitis.

7. The use according to claim 6, characterized in that: The drug is used to treat damp-heat type dermatitis and eczema.

8. The use according to claim 6, characterized in that: The dermatitis-related skin diseases mentioned are atopic dermatitis, seborrheic dermatitis, or neurodermatitis.

9. The use according to claim 6, characterized in that: The drug is available in oral or topical formulations.

10. The use according to claim 9, characterized in that: The medicine is a decoction, powder, oral liquid, ointment, granule, tablet, capsule, external wash, ointment, plaster, tincture or varnish.

Images