A quantitative tissue sampling gun with quick-change blade box and frozen docking function

Abstract

The application discloses a quantitative tissue sampling gun with a quick-change blade box and a freezing butt joint function, relates to the technical field of tissue sampling, and comprises a shell, a propelling adjusting mechanism arranged at the tail of the shell, a power mechanism arranged at the middle position of the inside of the shell, an executing mechanism arranged at the lower part of the shell, and a cutting and sampling mechanism arranged at the head of the shell. The quantitative tissue sampling gun can quantitatively control the cutting and sampling strength of the cutting and sampling mechanism through the propelling adjusting mechanism, can accurately sample materials, can accurately control the cutting depth, can quickly blow the sample from the cutting and sampling mechanism to a corresponding storage container through a discharging mechanism after sampling, and can lower the temperature in the inside of the shell through a cooling mechanism, so that the cutting and sampling mechanism has a lower temperature before sampling, the influence of the sample is reduced, RNA and proteins are prevented from being rapidly degraded due to long-time picking and transferring at room temperature, and the sampling quality is improved.

Description

Technical Field

[0001] This invention relates to the field of tissue sampling technology, specifically to a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function. Background Technology

[0002] In fields such as life sciences, clinical pathology, drug development, and forensic identification, obtaining high-quality, standardized tissue samples from organisms is fundamental for subsequent molecular biological analysis (such as genomics and proteomics) and pathological diagnosis.

[0003] Existing sampling tools are generally scalpels or ordinary biopsy needles, which rely heavily on the operator's subjective experience. It is difficult to control the sampling force during sampling, thus making it inconvenient to control the sampling accuracy. Moreover, if the sample is small, it is easy to lose it. The existing utility model patent with patent publication number CN208860625U discloses a biological sample collection gun, which improves the accuracy of sampling by setting a fixing device and a sampling device. During the biological sampling process, the sample is fixed first and then sampled. At the same time, the sampling needle is marked with scale marks on the outside, which ensures quantitative sampling of the sample and simplifies the work process. However, this existing technology still has the following problems: After biological tissue is removed from the body, the large molecules such as RNA and protein inside it will undergo thermal degradation due to their own enzyme activity and environmental temperature. The picking and transfer time during the sampling process is long, which can lead to damage to the integrity of biomolecules and affect the test results. Secondly, during sampling, the sampling needle needs to be pushed manually to collect the sample, and the other hand also needs to hold the handle. This is not only inconvenient to operate, but also makes it difficult to observe the sample collection process and the sampling depth of the sampling needle during operation, affecting the sampling accuracy. Summary of the Invention

[0004] The purpose of this invention is to provide a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, which solves the technical problems mentioned in the background art.

[0005] To solve the above-mentioned technical problems, the present invention specifically provides the following technical solution: A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function includes a pistol-shaped outer shell. A propulsion adjustment mechanism is located at the rear of the outer shell. A power mechanism is located in the middle of the inner part of the outer shell, and the propulsion force of the power mechanism is adjusted by the propulsion adjustment mechanism. An actuator for controlling the power mechanism to perform the pushing action is located at the lower part of the outer shell. A cutting and sampling mechanism connected to the power mechanism is located at the front of the outer shell. A sample feeding mechanism that blows off the sample using a jet of air is located on the inner sidewall of the outer shell. A cooling mechanism for reducing the ambient temperature of the cutting and sampling mechanism and a resetting mechanism for pushing the cutting and sampling mechanism back to its original position are located at the bottom of the outer shell.

[0006] As a preferred embodiment of the present invention, the propulsion adjustment mechanism includes an adjustment screw rotatably connected to the tail of the outer shell, one end of the adjustment screw extending to the tail of the outer shell and connected to an adjustment knob, a slider threadedly connected to the adjustment screw, a guide rail provided inside the outer shell, and the slider slidably connected to the guide rail.

[0007] As a preferred embodiment of the present invention, the power mechanism includes a push plate slidably connected in a guide rail, and the end of the guide rail is provided with a limiting protrusion for restricting the push plate from disengaging. The push plate is provided with a clearance hole for the adjustment screw to pass through. A first spring is provided on one side of the push plate, and one end of the first spring is connected to a transmission plate. The cutting and sampling mechanism is connected to the transmission plate, and the transmission plate is controlled to release or fix its position by an actuator.

[0008] As a preferred embodiment of the present invention, the top of the push plate is threadedly connected to a locking screw, the top of the locking screw is provided with a locking knob, and both the outer shell and the guide rail are provided with strip grooves for the movement of the locking screw.

[0009] In a preferred embodiment of the present invention, the actuator includes a trigger rotatably connected inside the housing via a torsion spring and a limiting plate rotatably connected to the inner wall of the housing via a torsion spring. The limiting plate is parallel to the inner bottom of the housing when the torsion spring is not under force. A pressure plate is provided on the top of the trigger for pressing the limiting plate to rotate. A magnetic strip is provided on the inner wall of the housing for magnetically adsorbing and fixing the limiting plate. An unlocking structure is provided on one side of the transmission plate. The unlocking structure releases the magnetic strip from fixing the limiting plate after the cutting and sampling mechanism is reset. A working groove for the trigger to rotate is provided at the bottom of the housing.

[0010] As a preferred embodiment of the present invention, the unlocking structure includes a first connecting plate vertically disposed on the side wall of the transmission plate opposite to the push plate and a second connecting plate vertically disposed on the first connecting plate, a wedge plate vertically disposed on the second connecting plate, and a guide angle disposed on the limiting plate.

[0011] As a preferred embodiment of the present invention, the cutting and sampling mechanism includes a push rod that is perpendicularly connected to the transmission plate, an extension plate is provided on the end of the push rod that is away from the transmission plate, a third connecting plate is perpendicularly connected to the extension plate, an annular cutter is provided on the third connecting plate, and a sampling port for the annular cutter to enter and exit is provided at the end of the outer shell.

[0012] As a preferred embodiment of the present invention, the feeding mechanism includes a micro air pump and a nozzle, and the nozzle is connected to the micro air pump through a pipeline. The micro air pump is connected to a power supply and a switch. A hollow handle is provided at the bottom of the housing. The micro air pump and the power supply are both located inside the handle, and the switch is located on the outer wall of the handle.

[0013] As a preferred embodiment of the present invention, the cooling mechanism includes a slot formed at the bottom of the outer shell, a cooling box slidably inserted into the slot, and a phase change cold storage agent stored in the cooling box. The cooling box is interference-fitted with the slot, a magnetic button is provided at the bottom of the cooling box, and an annular plate is provided on the outside of the outer shell that can be magnetically attracted to the magnetic button.

[0014] As a preferred embodiment of the present invention, the reset mechanism includes a reset rod fixedly sleeved on the push rod, and a reset push block slidably connected to the bottom of the housing is provided at the bottom of the reset rod. A straight groove is provided on the housing for the reset rod to pass through.

[0015] Compared with the prior art, the present invention has the following advantages: This invention enables precise material sampling by quantitatively controlling the cutting and sampling force of the cutting and sampling mechanism through an adjustment mechanism. The cutting depth can be precisely controlled. After sampling, the sample can be quickly blown from the cutting and sampling mechanism into the corresponding storage container through a feeding mechanism. Furthermore, the internal temperature of the outer shell is reduced by a cooling mechanism, so that the cutting and sampling mechanism has a low temperature before sampling, reducing the influence of the sample and avoiding the rapid degradation of macromolecules such as RNA and protein caused by prolonged picking and transferring at room temperature. This improves the quality of sampling and ensures the accuracy of the test results. Attached Figure Description

[0016] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0017] Figure 1 This invention provides a schematic diagram of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function. Figure 1 ; Figure 2 This invention provides a schematic diagram of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function. Figure 2 ; Figure 3This is a partial structural diagram of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, provided in an embodiment of the present invention. Figure 4 This invention provides a cross-sectional view of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, as shown in the embodiment of the invention. Figure 1 ; Figure 5 This invention provides a cross-sectional view of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, as shown in the embodiment of the invention. Figure 2 ; Figure 6 This invention provides a cross-sectional view of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, as shown in the embodiment of the invention. Figure 3 ; Figure 7 This invention provides a cross-sectional view of a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, as shown in the embodiment of the invention. Figure 4 ; Figure 8 Provided for embodiments of the present invention Figure 7 An enlarged structural diagram of part A shown in the figure; Figure 9 Provided for embodiments of the present invention Figure 5 An enlarged structural diagram of part B shown in the figure; Figure 10 Provided for embodiments of the present invention Figure 6 The diagram shows an enlarged view of the structure of part C.

[0018] The labels in the diagram represent the following: 1. Outer shell; 2. Propulsion and adjustment mechanism; 3. Power mechanism; 4. Actuating mechanism; 5. Cutting and sampling mechanism; 6. Unloading mechanism; 7. Cooling mechanism; 8. Reset mechanism; 201. Adjusting screw; 202. Adjusting knob; 203. Slider; 204. Guide rail; 301. Push plate; 302. Clearance hole; 303. First spring; 304. Transmission plate; 305. Locking screw; 306. Locking knob; 307. Strip groove; 401. Trigger; 402. Limiting plate; 403. Pressure plate; 404. Magnetic strip; 405. Unlocking structure; 406. First connecting plate; 407. Second connecting plate; 408, wedge plate; 409, guide bevel; 410, working groove; 501, push rod; 502, extension plate; 503, third connecting plate; 504, annular cutter; 505, sampling port; 601, miniature air pump; 602, nozzle; 701, slot; 702, cooling box; 703, magnetic button; 704, annular plate; 801, reset rod; 802, reset push block; 803, straight groove. Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] The concepts involved in this application will first be described with reference to the accompanying drawings. It should be noted that the following descriptions of various concepts are only for the purpose of making the content of this application easier to understand and do not constitute a limitation on the scope of protection of this application; furthermore, the embodiments and features in the embodiments of this application can be combined with each other unless otherwise specified. This application will now be described in detail with reference to the accompanying drawings and embodiments.

[0021] like Figures 1 to 10 As shown, the present invention provides a quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, including a pistol-shaped outer shell 1, a propulsion adjustment mechanism 2 at the rear of the outer shell 1, a power mechanism 3 at the middle of the interior of the outer shell 1, and the power mechanism 3 adjusting the propulsion force through the propulsion adjustment mechanism 2, an execution mechanism 4 at the lower part of the outer shell 1 for controlling the power mechanism 3 to perform the pushing action, a cutting and sampling mechanism 5 connected to the power mechanism 3 at the front of the outer shell 1, a feeding mechanism 6 for blowing off the sample by jet air on the inner side wall of the outer shell 1, and a cooling mechanism 7 for reducing the ambient temperature of the cutting and sampling mechanism 5 and a resetting mechanism 8 for pushing back the cutting and sampling mechanism 5 to reset at the bottom of the outer shell 1.

[0022] When sampling, the outer casing 1 is pistol-shaped. The operator holds the outer casing 1 and adjusts the magnitude of the propulsion force output by the power mechanism 3 through the propulsion adjustment mechanism 2, thereby controlling the force of the cutting and sampling mechanism 5 during cutting and sampling. This allows for more precise control of the sampling depth and more convenient control of the sampling accuracy. Furthermore, it eliminates the need to observe the sampling process, thus improving portability and control over sampling accuracy.

[0023] The operator controls the power mechanism 3 through the actuator 4 to drive the cutting and sampling mechanism 5 to extend into the outer shell 1 for sampling. After sampling is completed, the cutting and sampling mechanism 5 is manually retracted into the outer shell 1, and the obtained sample is recovered into the low-temperature storage mechanism 6. This avoids the large molecules such as RNA and protein from being thermally degraded due to environmental temperature and their own enzyme activity due to excessive exposure time, thereby avoiding the integrity of biomolecules being affected and ensuring the accuracy of the test results.

[0024] The propulsion adjustment mechanism 2 includes an adjustment screw 201 rotatably connected to the tail of the housing 1. One end of the adjustment screw 201 extends to the tail of the housing 1 and is connected to an adjustment knob 202. A slider 203 is threadedly connected to the adjustment screw 201. A guide rail 204 is provided inside the housing 1, and the slider 203 is slidably connected to the guide rail 204.

[0025] When in use, the adjustment mechanism 2 drives the adjustment screw 201 to rotate by rotating the adjustment knob 202, thereby driving the slider 203 to slide on the guide rail 204, thereby adjusting the position of the slider 203, so as to adjust the magnitude of the force output by the power mechanism 3 by squeezing the power mechanism 3 through the slider 203.

[0026] The power mechanism 3 includes a push plate 301 slidably connected in the guide rail 204, and the end of the guide rail 204 is provided with a limiting protrusion for limiting the push plate 301 from disengaging. The push plate 301 is provided with a clearance hole 302 for the adjustment screw 201 to pass through. A first spring 303 is provided on one side of the push plate 301, and one end of the first spring 303 is connected to a transmission plate 304. The cutting and sampling mechanism 5 is connected to the transmission plate 304, and the transmission plate 304 is controlled to release or fix its position by the execution mechanism 4.

[0027] The push plate 301 is driven by the slider 203 to slide on the guide rail 204. The transmission plate 304 does not change position under the restriction of the actuator 4, so that the push plate 301 compresses the first spring 303. At this time, the first spring 303 accumulates elastic potential energy.

[0028] When the actuator 4 releases the restriction on the transmission plate 304, the transmission plate 304 is released. At this time, under the elastic force of the first spring 303, the transmission plate 304 drives the cutting and sampling mechanism 5 to quickly extend outward of the outer shell 1 and perform cutting and sampling. By controlling the compression deformation of the first spring 303, the cutting depth of the cutting and sampling mechanism 5 is controlled, thereby controlling the sampling accuracy.

[0029] The top of the push plate 301 is threaded with a locking screw 305, and the top of the locking screw 305 is provided with a locking knob 306. Both the outer casing 1 and the guide rail 204 are provided with strip grooves 307 for the locking screw 305 to move.

[0030] When the slider 203 pushes the push plate 301 to the corresponding position, the locking knob 306 is rotated to drive the locking screw 305 to rotate synchronously, so that the locking knob 306 rotates to abut against the top outer wall of the housing 1, thereby locking the position of the push plate 301 and preventing the push plate 301 from moving synchronously when the first spring 303 drives the transmission plate 304, thereby avoiding affecting the sampling depth of the cutting sampling mechanism 5.

[0031] The actuator 4 includes a trigger 401 rotatably connected inside the housing 1 via a torsion spring and a limiting plate 402 rotatably connected to the inner wall of the housing 1 via a torsion spring. When the torsion spring is not under force, the limiting plate 402 is parallel to the inner bottom of the housing 1. The top of the trigger 401 is provided with a pressure plate 403 for pressing the limiting plate 402 to rotate. The inner wall of the housing 1 is provided with a magnetic strip 404 for fixing the limiting plate 402 by magnetic attraction. One side of the transmission plate 304 is provided with an unlocking structure 405. After the cutting and sampling mechanism 5 is reset, the unlocking structure 405 releases the magnetic strip 404 from fixing the limiting plate 402. The bottom of the housing 1 is provided with a working groove 410 for the trigger 401 to rotate.

[0032] The unlocking structure 405 includes a first connecting plate 406 vertically disposed on the side wall of the transmission plate 304 away from the push plate 301 and a second connecting plate 407 vertically disposed on the first connecting plate 406. A wedge plate 408 is vertically disposed on the second connecting plate 407 and a guide angle 409 is disposed on the limiting plate 402.

[0033] When the transmission plate 304 is in a fixed position, the limiting plate 402 is located in front of the transmission plate 304 and abuts against the transmission plate 304. When it is necessary to release the transmission plate 304, the operator presses the trigger 401 with his finger. After the trigger 401 rotates, it drives the pressure plate 403 to press down the limiting plate 402 and rotate downward. When the limiting plate 402 disengages from the transmission plate 304, the transmission plate 304 is ejected under the elastic force of the first spring 303 and drives the cutting and sampling mechanism 5 to perform sampling. When the operator presses the trigger 401 to the limit position, the limiting plate 402 contacts the magnetic strip 404. The torsion spring at the limiting plate 402 is compressed and the limiting plate 402 is fixed by the magnetic force of the magnetic strip 404, so that the limiting plate 402 will not interfere when the cutting and sampling mechanism 5 is reset.

[0034] When the operator pushes the cutting and sampling mechanism 5 to reset, the unlocking structure 405 on the transmission plate 304 releases the fixation of the limiting plate 402 when the transmission plate 304 passes the position of the magnetic strip 404. Specifically, when the cutting and sampling mechanism 5 resets, the transmission plate 304 drives the first connecting plate 406 and the second connecting plate 407 to move synchronously, and drives the wedge plate 408 to move to the limiting plate 402. Through the guide angle 409 on the limiting plate 402, the wedge plate 408 cuts into the limiting plate. Between the positioning plate 402 and the magnetic strip 404, the limiting plate 402 gradually moves away from the magnetic strip 404. When the transmission plate 304 passes the position of the limiting plate 402, the limiting plate 402 is completely disengaged from the magnetic strip 404 by the squeezing of the wedge plate 408, and resets to the front of the transmission plate 304 under the action of the torsion spring. The transmission plate 304 abuts against the limiting plate 402 under the elastic force of the first spring 303. At this time, the reset operation of the cutting sampling mechanism 5 is completed.

[0035] The first connecting plate 406 and the second connecting plate 407 are perpendicularly connected to each other, so that there is a blank area between the wedge plate 408 and the first connecting plate 406. This avoids interference with the reset of the limiting plate 402 and allows the magnetic strip 404 to be released from the limiting plate 402 through the wedge plate 408.

[0036] The cutting and sampling mechanism 5 includes a push rod 501 that is perpendicularly connected to the transmission plate 304. An extension plate 502 is provided on the end of the push rod 501 that is away from the transmission plate 301. A third connecting plate 503 is perpendicularly connected to the extension plate 502. An annular cutter 504 is provided on the third connecting plate 503. A sampling port 505 for the annular cutter 504 to enter and exit is provided at the end of the outer shell 1.

[0037] Driven by the transmission plate 304, the push rod 501 drives the annular cutter 504 through the extension plate 502 and the third connecting plate 503 to extend to the outside of the housing 1 for sampling.

[0038] The annular cutter 504 is connected by the extension plate 502 and the third connecting plate 503, so that there is a large blank space between the annular cutter 504 and the push rod 501, so that the sample will not be interfered with when it falls into the low temperature preservation mechanism 6.

[0039] When the cutting and sampling mechanism 5 is reset, the operator can use a hand tool to squeeze the annular cutter 504 to reset the entire cutting and sampling mechanism 5.

[0040] Furthermore, a scale (0.1-2mm scale) can be set on the top of the housing 1, and the locking screw 305 is aligned with the scale to indicate the extension length of the cutting sampling mechanism 5 when it pops out for sampling.

[0041] The feeding mechanism 6 includes a micro air pump 601 and a nozzle 602. The nozzle 602 is connected to the micro air pump 601 through a pipeline. The micro air pump 601 is connected to a power supply and a switch. A hollow handle is provided at the bottom of the housing 1. The micro air pump 601 and the power supply are both located inside the handle, and the switch is located on the outer wall of the handle.

[0042] After the sample is cut, the micro air pump 601 can be started by pressing the switch after the cutting and sampling mechanism 5 is reset by the reset mechanism 8. The micro air pump 601 sprays airflow through the pipeline and nozzle 602 to the inside of the annular cutter 504. The airflow pushes the sample inside the annular cutter 504 to slide out of the outer shell 1 and fall into the container that is aligned with the upper port of the outer shell 1. The container can be a container with heat preservation effect, so that the internal temperature is low when storing the sample to ensure that the sample does not deteriorate.

[0043] In this embodiment, the miniature air pump 601, the power supply, and the switch are all existing technologies, and their technical principles will not be elaborated upon here.

[0044] The cooling mechanism 7 includes a slot 701 at the bottom of the outer casing 1. A cooling box 702 is slidably inserted into the slot 701, and a phase change refrigerant is stored in the cooling box 702. The cooling box 702 is interference-fitted with the slot 701. A magnetic button 703 is provided at the bottom of the cooling box 702. An annular plate 704 is provided on the outside of the outer casing 1, which can be magnetically attracted to the magnetic button 703.

[0045] The cooling box 702 is inserted into the slot 701 from the bottom. Since the two are interference fit, the cooling box 702 can be stably connected to the slot 701. The phase change cold storage agent placed in the cooling box 702 reduces the ambient temperature in the corresponding area inside the outer shell 1, so that the annular cutter 504 has a low temperature before cutting and sampling, reducing the impact on the sample.

[0046] The stability of the cooling box 702 after installation is further improved by the magnetic pressing plate 703 and the ring plate 704 attracting each other.

[0047] In this application, the phase change refrigerant is existing technology. Inorganic hydrated salt phase change materials (such as calcium chloride hydrate, sodium sulfate hydrate, etc., with their phase change point adjusted to around 2°C) can be used, or organic phase change materials (such as specific n-alkanes, fatty acids, or their eutectic mixtures, which have good chemical stability and are non-toxic) can be used. These materials can absorb or release a large amount of latent heat during the phase change process, thereby maintaining a constant low temperature inside the outer shell 1 for a relatively long period. The technical principles will not be elaborated upon here.

[0048] The reset mechanism 8 includes a reset rod 801 fixedly sleeved on the push rod 501. The bottom of the reset rod 801 is provided with a reset push block 802 that is slidably connected to the bottom of the housing 1. The housing 1 is provided with a straight groove 803 for the reset rod 801 to pass through.

[0049] When resetting the cutting and sampling mechanism 5, the operator manually pushes the reset push block 802 in the opposite direction to the ejection direction of the annular cutter 504. The reset rod 801 drives the annular cutter 504 to reset until the transmission plate 304 passes the position of the limit plate 402. At this time, the limit plate 402 is completely disengaged from the magnetic strip 404 and resets to the front of the transmission plate 304 under the action of the torsion spring. The transmission plate 304 abuts against the limit plate 402 under the elastic force of the first spring 303. At this time, the reset operation of the cutting and sampling mechanism 5 is completed.

[0050] Furthermore, a stop is provided inside the housing 1 to abut against the annular cutter 504, so as to position the annular cutter 504 during reset. When the annular cutter 504 moves to abut against the stop during the reset process, the reset is completed.

[0051] The embodiments and / or implementation methods described above are merely preferred embodiments and / or implementation methods for implementing the technology of the present invention, and are not intended to limit the implementation methods of the technology of the present invention in any way. Any person skilled in the art can make some modifications or alterations to other equivalent embodiments without departing from the scope of the technical means disclosed in the content of the present invention, but they should still be regarded as the technology or embodiments that are substantially the same as the present invention. This document uses specific examples to illustrate the principles and implementation methods of this application. The descriptions of the above embodiments are only for the purpose of helping to understand the methods and core ideas of this application. The above descriptions are only preferred embodiments of this application. It should be noted that due to the limitations of written expression, while there are objectively infinite specific structures, those skilled in the art can make several improvements, modifications, or changes without departing from the principles of this application, and can also combine the above technical features in an appropriate manner. These improvements, modifications, changes, or combinations, or the direct application of the inventive concept and technical solution to other situations without modification, should all be considered within the scope of protection of this application.

Claims

1. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function, characterized in that, The device includes a pistol-shaped outer shell (1), a propulsion adjustment mechanism (2) at the tail of the outer shell (1), a power mechanism (3) at the middle of the interior of the outer shell (1), and the power mechanism (3) adjusts the propulsion force through the propulsion adjustment mechanism (2). The lower part of the outer shell (1) is provided with an execution mechanism (4) for controlling the power mechanism (3) to perform the pushing action. The front part of the outer shell (1) is provided with a cutting and sampling mechanism (5) connected to the power mechanism (3). The inner side wall of the outer shell (1) is provided with a feeding mechanism (6) for blowing samples down by jet air. The bottom of the outer shell (1) is provided with a cooling mechanism (7) for reducing the ambient temperature of the cutting and sampling mechanism (5) and a reset mechanism (8) for pushing back the cutting and sampling mechanism (5) to reset.

2. The quantitative tissue sampling gun with quick-change blade box and cryo-docking function according to claim 1, characterized in that, The propulsion adjustment mechanism (2) includes an adjustment screw (201) rotatably connected to the tail of the outer shell (1). One end of the adjustment screw (201) extends to the tail of the outer shell (1) and is connected to an adjustment knob (202). A slider (203) is threaded onto the adjustment screw (201). A guide rail (204) is provided inside the outer shell (1), and the slider (203) is slidably connected to the guide rail (204).

3. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 2, characterized in that, The power mechanism (3) includes a push plate (301) slidably connected in the guide rail (204), and the end of the guide rail (204) is provided with a limiting protrusion for limiting the push plate (301) from disengaging. The push plate (301) is provided with a clearance hole (302) for the adjustment screw (201) to pass through. A first spring (303) is provided on one side of the push plate (301), and one end of the first spring (303) is connected to a transmission plate (304). The cutting and sampling mechanism (5) is connected to the transmission plate (304) and controls the transmission plate (304) to release or fix its position through the actuator (4).

4. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 3, characterized in that, The top of the push plate (301) is threaded with a locking screw (305), and the top of the locking screw (305) is provided with a locking knob (306). The outer shell (1) and the guide rail (204) are both provided with a strip groove (307) for the locking screw (305) to move.

5. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 3, characterized in that, The actuator (4) includes a trigger (401) rotatably connected to the inside of the housing (1) by a torsion spring and a limiting plate (402) rotatably connected to the inner wall of the housing (1) by a torsion spring. The limiting plate (402) is parallel to the inner bottom of the housing (1) when the torsion spring is not under force. The top of the trigger (401) is provided with a pressure plate (403) for pressing the limiting plate (402) to rotate. The inner wall of the housing (1) is provided with a magnetic strip (404) for fixing the limiting plate (402) by magnetic attraction. The transmission plate (304) is provided with an unlocking structure (405) on one side. The unlocking structure (405) releases the magnetic strip (404) from fixing the limiting plate (402) after the cutting and sampling mechanism (5) is reset. The bottom of the housing (1) is provided with a working groove (410) for the trigger (401) to rotate.

6. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 5, characterized in that, The unlocking structure (405) includes a first connecting plate (406) vertically disposed on the side wall of the transmission plate (304) away from the push plate (301) and a second connecting plate (407) vertically disposed on the first connecting plate (406). A wedge plate (408) is vertically disposed on the second connecting plate (407), and a guide angle (409) is disposed on the limiting plate (402).

7. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 3, characterized in that, The cutting and sampling mechanism (5) includes a push rod (501) that is perpendicularly connected to the transmission plate (304). An extension plate (502) is provided on the end of the push rod (501) that is away from the transmission plate (304). A third connecting plate (503) is perpendicularly connected to the extension plate (502). An annular cutter (504) is provided on the third connecting plate (503). A sampling port (505) for the annular cutter (504) to enter and exit is provided at the end of the outer shell (1).

8. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 1, characterized in that, The feeding mechanism (6) includes a micro air pump (601) and a nozzle (602), and the nozzle (602) is connected to the micro air pump (601) through a pipeline. The micro air pump (601) is connected to a power supply and a switch. A hollow handle is provided at the bottom of the outer shell (1). The micro air pump (601) and the power supply are both located inside the handle. The switch is located on the outer wall of the handle.

9. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 1, characterized in that, The cooling mechanism (7) includes a slot (701) at the bottom of the outer shell (1), a cooling box (702) is slidably inserted in the slot (701), and a phase change cold storage agent is stored in the cooling box (702). The cooling box (702) is interference-fitted with the slot (701). A magnetic button (703) is provided at the bottom of the cooling box (702). An annular plate (704) is provided on the outside of the outer shell (1) and can be magnetically attracted to the magnetic button (703).

10. A quantitative tissue sampling gun with a quick-change blade box and cryo-docking function according to claim 7, characterized in that, The reset mechanism (8) includes a reset rod (801) fixedly sleeved on the push rod (501). The bottom of the reset rod (801) is provided with a reset push block (802) that is slidably connected to the bottom of the outer shell (1). The outer shell (1) is provided with a straight groove (803) for the reset rod (801) to pass through.

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