Sunscreen compositions with spf boosters

Abstract

The present invention relates to sunscreen formulations with an SPF booster based on microporous particles having a specific particle size distribution (PSD).

Description

Technical Field

[0001] This invention generally relates to sunscreen compositions for protecting against damage from ultraviolet (UV) rays. More specifically, this invention relates to formulations having an SPF synergist based on microporous particles having a specific particle size distribution (PSD).

[0002] describe

[0003] It is generally believed that exposure to ultraviolet (UV) light with wavelengths from about 200 nm to about 400 nm has negative effects. Prolonged, unprotected exposure to solar radiation leads to adverse health consequences, such as immediate painful sunburn, and long-term damage that can cause serious conditions such as skin cancer.

[0004] Ultraviolet light also accelerates aging by inducing the formation of free radicals in the skin. Free radicals include, for example, singlet oxygen, hydroxyl radicals, superoxide anions, nitric oxide, and hydrogen radicals. Free radicals attack DNA, membrane lipids, and proteins, generating carbon radicals. These then react with oxygen to produce peroxy radicals, which can attack neighboring fatty acids to generate new carbon radicals. This cascade leads to a chain reaction, resulting in lipid peroxidation products. Damage to cell membranes leads to loss of cell permeability, increased intercellular ion concentration, and reduced ability to excrete or detoxify waste products.

[0005] Different sunscreen compositions can be used to reduce the amount of solar UV radiation received by the skin during exposure to solar radiation.

[0006] Sunscreen compositions may contain inorganic UV filters (also known as physical filters) and / or chemical UV filters (which are organic molecules). Inorganic UV filters interact with UV light through two mechanisms: absorption and reflection / scattering, while organic filters typically contain aromatic carbons and / or other electronically dense bonds responsible for absorbing light in the UV range of the solar spectrum.

[0007] The higher the amount of UV filter, the greater the level of UV protection. However, it has recently become clear that excessively high concentrations of both inorganic and organic UV filters not only compromise the aesthetics of sunscreen products but also pose adverse safety risks to both human health and the environment.

[0008] Therefore, a key challenge in this field is to reduce the amount of UV filters used in sunscreen formulations while still ensuring high sun protection efficacy.

[0009] Accordingly, an effective strategy for addressing this problem involves using sun protection factor (SPF) enhancers in sunscreen formulations. SPF enhancers are defined as compounds that are safe for both human use and the environment, are not considered active sunscreen ingredients, but serve to increase the SPF of compositions in which they are incorporated. Under certain regulations (i.e., European Cosmetics Regulation 1223 / 2009), SPF formulations must provide SPF protection consisting of a UVA protection factor (UVAPF) of at least one-third of the total SPF, with a critical wavelength of 370 nm or greater. This is necessary to reduce the efficiency of UVA penetration into the dermis and to promote photosensitization reactions that can generate harmful reactive oxygen species.

[0010] Typical sunscreen formulations are emulsions, serums, creams, or gels and sprays. In addition to chemical and / or physical UV filters, they contain many other compounds such as emulsifiers, solubilizers, stabilizers, preservatives, and SPF enhancers; all of these affect the protective properties of the sunscreen, the activity of the SPF enhancer, and the cosmetic appeal.

[0011] As reported in WO2017112982 and WO2021102873, a widely used inorganic SPF synergist is represented by hydrophobic silica particles. Furthermore, US9265715 claims protection for, for example, the use of silica particles in combination with nylon particles and barium sulfate particles to enhance the effect of sunscreen compositions. Another example is represented by US20210330571, in which hydrophobic fine particles of titanium dioxide or zinc oxide ensure a synergistic effect on the final composition. Alternatively, WO2022081942 describes an organic compound, specifically xanthocyanin, as an SPF synergist in combination with chemical UV filters.

[0012] In addition, another typical approach in the field of SPF synergists is to use particles characterized by a specific size that overlaps with the range of UV light (i.e., about 200 nm to 400 nm) in order to take advantage of the UV scattering mechanism, as reported in US10485745.

[0013] However, some of the most frequently cited compound classes, such as silica, have been gradually phased out due to their toxicity to humans and the environment. Inorganic compounds such as titanium dioxide and zinc oxide, or organic compounds such as celestin reported above, cannot be considered SPF enhancers because they act as true UV filters (the so-called SPF doping effect).

[0014] Therefore, the object of the present invention is to develop sunscreen compositions characterized by the presence of novel universal SPF synergists.

[0015] In particular, the inventors have discovered that in sunscreen compositions containing at least one UV filter, when the SPF enhancer is based on microporous particles having a particle size distribution (PSD) of 100 nm to 10 µm, specifically divided into three fractions, an unexpected improvement in the enhancing effect on both UVB and UVA values ​​can be obtained.

[0016] The fractions are defined as a first fraction of 100 nm to 400 nm, a second fraction of 400 nm to 1 µm, and a third fraction of 1 µm to 10 µm, characterized in that the amount of the second fraction is in the ratio of the sum of the first and third fractions to 0.1 to 5.

[0017] Zeolite particle size distribution (PSD) was measured using a conventional laser diffraction instrument. The powder was dispersed in DI water using a US bath until a suitable concentration was achieved to generate an optimal light-blocking signal in the instrument. The slurry was recycled from the container to the detector, and the particle size distribution was measured. Specifically, the cumulative number distribution was evaluated. The diameter fraction was calculated from the cumulative curve (e.g., the 0.1 µm to 0.4 µm fraction is the cumulative curve value within this range). All SPF synergists of this invention do not exhibit sunscreen activity as single components, but when added to formulations containing UV filters, they act as effective SPF and UVA-PF synergists; thus avoiding the SPF dopant effect according to international safety regulations.

[0018] According to the present invention, the amount of SPF synergist particles is 0.1% to 5% by weight relative to the total weight of the composition, and the amount of UV filter is 1.0% to 35% by weight relative to the total weight of the composition.

[0019] In a preferred embodiment, specifically when an organic UV filter is used, the amount of the compound is 1% to 15% by weight relative to the total amount of the composition, while when the filter is an inorganic compound, the amount is preferably 1% to 25% by weight relative to the total amount of the composition.

[0020] In fact, the UV filter used in the sunscreen composition described herein can be an organic molecule (also defined as a chemical filter), an inorganic compound (also defined as a physical filter), or a mixture thereof.

[0021] The organic molecules are selected from hexyl diethylaminohydroxybenzoylbenzoate, ethylhexyl salicylate, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazine ketone, phenylbenzimidazole sulfonic acid, Octocrylene, humosasulfonate, butyl methoxydibenzoylmethane, trimethylcyclohexyl salicylate, ethylhexyl methoxycinnamate, benzophenone-3, ethylhexyl dimethyl p-aminobenzoic acid, benzophenone-4, triethanolamine salicylate, terephthalamide dicamphor sulfonic acid, cresoltrazolium trisiloxane and 4-methylbenzyl camphor polysiloxane-16, avobenzone, diethylhexylbutamidotriazine ketone, tri-biphenyl triazine, and tris-biphenyl triazine. yltrazine), oxybenzone, octyltriazine, octyl salicylate, pardimethicone O, bis-piperazine HAA299, (2-ethoxyethyl(2Z)-2-cyano-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-yl]acetate), sulphone, cresoltrazolium trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol, benzyl camphor sulfonic acid, 4-methylbenzyl camphor, polysiloxane-15, sodium sulphone, aminobenzoic acid, PEG-25PABA, menthyl anthranilate, isopentyl-4-methoxycinnamate, dioxibenzone, cinoxazone, camphor benzalkonium sulfate, and mixtures thereof.

[0022] The inorganic compounds are selected from zinc oxide, titanium dioxide, aluminum stearate, aluminum oxide, hydrated silicon dioxide or aluminum hydroxide, mixtures thereof, and surface-modified oxides.

[0023] In certain formulations, UV filters may also contain bacteria-based systems.

[0024] In a preferred embodiment, the SPF synergist particles are characterized by a crystal structure with a crystallinity of more than 30% and an aspect ratio of 0.1 to 1, wherein the aspect ratio is defined as the ratio of the width (W) to the height (H) of the projection of the boundary rectangle of the particle shape in a 2D image.

[0025] According to another aspect of the invention, the synergist particles are characterized by a refractive index of 1.35 to 1.65.

[0026] Both inorganic and organic materials can be used as SPF synergists characterized by the specific size distribution reported above.

[0027] Specifically, the preferred inorganic particles are those with an orthorhombic or cubic unit cell structure and a diameter of 200 μm. 2 / g to 1000 m 2 Zeolites characterized by a surface area of ​​ / g.

[0028] In a preferred embodiment, the zeolite is selected from octahedral zeolite (FAU), Linde type A (LTA), mordenite (MOR), β type, or a mixture of Linde type A (LTA) and ZSM-5 type.

[0029] The preferred organic particles according to the present invention have a metal-organic framework, preferably cyclodextrin, with a surface area of ​​1000 m². 2 / g to 5000 m 2 / g.

[0030] As reported in the Experimental Section below, the specific zeolite ensures a UVB performance enhancement of at least 20% for the final composition, and simultaneously, a UVA-PF enhancement of at least 10%.

[0031] The sunscreen compositions disclosed herein can be formulated as monophasic agents, which offers advantages in cosmetics because they do not leave a greasy or white cast on the skin, making them ideal for use under or over makeup, and they do not clog pores. They also ensure the benefits of sunscreen activity because they are specifically targeted at areas requiring increased protection, such as the cheeks, nose, or ears, and are generally the most water-resistant formulations.

[0032] Therefore, the single-phase formulations according to the present invention are preferably in rod form and are anhydrous phases selected from all of the following types: oils, waxes, emollients, emulsifiers, silicones, polymers, esters, film-forming agents, solubilizers, organic / inorganic dispersants and rheology modifiers, fats, solvents and carriers, stabilizers, organic gelling components and inorganic gelling components.

[0033] In another embodiment, the same anhydrous phase referenced above can be combined with an aqueous phase to obtain an oil-in-water formulation, characterized by a high sensory and tactile quality on the skin due to a suitable balance between the aqueous and oil phases. The homogeneous oil-in-water emulsion is preferably formulated as a serum or cream.

[0034] The sunscreen composition according to the present invention may further comprise at least one of the following: cosmetically acceptable emollients, carriers, pigments, humectants, vitamins, antioxidants, natural colorants, preservatives, fragrances, conditioning agents, emulsifiers, solubilizers, dispersants, film-forming agents, rheology modifiers, sensory modifiers, solvents, carriers, stabilizers, conditioning agents, fillers, extracts, essential oils, or surfactants.

[0035] The present invention also relates to compositions according to any embodiment disclosed herein, which serve as sunscreen compositions or sunscreen agents. In particular, the present invention relates to compositions according to any embodiment disclosed herein, which are used in methods for protecting stratum corneum surfaces (e.g., skin) from UV radiation, the methods comprising contacting the stratum corneum surface with the sunscreen composition of the present invention.

[0036] The present invention also relates to compositions as disclosed herein, which serve as additives or excipients in sunscreen compositions.

[0037] Surprisingly, the SPF synergistic effect was achieved by the compositions and / or functionalized zeolites of the present invention without the zeolite being bound to the filter (e.g., without absorption or encapsulation). In fact, according to the present invention, the zeolite and UV filter do not interact, but only form a physical mixture. As demonstrated by SEM images (FESEM – EDS (Supra 55VP / Zeiss + UltraMax 170mm² / Oxford Instruments)), according to the present invention, the zeolite is not bound and is not part of the UV filter, and does not act as a carrier. As will become apparent from the following experimental section, the zeolite according to the present invention actually has a synergistic effect. This is also confirmed by the fact that, in the absence of a UV filter, the zeolite of the present invention does not function as a sunscreen filter.

[0038] As will be apparent to those skilled in the art, the compositions of the present invention can be included in a variety of articles and products, such as: leave-in lotions and creams, shampoos, conditioners, shower gels, toilette bars, antiperspirants, deodorants, shaving creams, lipsticks, lip balms, stick formulations, foundations, sunscreens, etc. It should be noted that sunscreen agents are only active upon exposure to UV radiation. In cases where protection against UV radiation / sunburn is not required, such as when the composition is used as a shower gel, applying the composition to the skin cannot be considered a therapeutic treatment, and the composition is primarily intended for use as a cosmetic rather than a pharmaceutical.

[0039] Therefore, the present invention also relates to non-therapeutic uses of compositions according to any embodiment disclosed herein, such as cosmetic uses.

[0040] Other aspects and advantages of the invention will become apparent from the following experimental section.

[0041] Example

[0042] The invention will now be described in more detail with reference to the following non-limiting embodiments. It will be apparent to those skilled in the art that modifications or variations of the embodiments illustrated herein are covered by the appended claims.

[0043] Preparation of comparative sunscreen compositions and sunscreen compositions of the present invention (P5, S1 to S2)

[0044] The reference sunscreen formulation P5, as described in ISO standard 24444:2019 "Cosmetics — Sunprotection test Methods", was used as the base formulation for evaluating SPF and UVA-PF enhancers. As reported in Table 1, the reference sunscreen formulation P5 comprises a mixture of different chemical filters made from 3% by weight butyl methoxydibenzoylmethane, 10% by weight occrylene, 5% by weight ethylhexyl salicylate, and 5% by weight benzophenone-3.

[0045] Table 1. P5 Reference Formulation

[0046]

[0047]

[0048] The final formulations of S1 and S2 were then prepared by transferring 97g of P5 to a mixing tank and adding 3.0g of "SPF synergist" while stirring. A homogenizer was then used to achieve a fine particle distribution.

[0049] Preparation of rod formulation - UV filter - formulation placebo #B1

[0050] method:

[0051] 1. Combine and mix the reagents (1 to 5) of phase A together, and heat to 80°C to 85°C until fully melted and homogeneous.

[0052] 2. Individually, mix all reagents (6 to 9) of phase B together and heat to 80°C to 85°C until fully melted and homogeneous.

[0053] 3. Add phase B to phase A and stir until homogeneous.

[0054] 4. Remove it from the heat source and mix it with the pre-blended phase C (10 to 12). Pour it out while it is still molten.

[0055] Table 2.

[0056]

[0057] Preparation of rod formulations - UV filters and zeolite SPF synergist powders - Formulation samples #S3 to S4

[0058] method:

[0059] 1. Combine and mix the reagents (1 to 5) of phase A together, and heat to 80°C to 85°C until fully melted and homogeneous.

[0060] 2. Individually, mix all reagents (6 to 9) of phase B together and heat to 80°C to 85°C until fully melted and homogeneous.

[0061] 3. Add phase B to phase A and stir until homogeneous.

[0062] 4. Remove it from the heat source and mix it with the pre-blended phase C (10 to 12). Pour it out while it is still molten.

[0063] Table 3.

[0064]

[0065] Preparation of water-in-oil cream formulations – UV filter and zeolite SPF synergist powders – placebo B2 and sample #S5

[0066] Zeolite is incorporated into ready-to-use, ocean-friendly sunscreen emulsions via post-processing. Specifically, a ready-to-use O / W emulsion with SPF 50 is mixed with β-zeolite at 5000 rpm for 5 minutes at room temperature using Turrax until a homogeneous blend is achieved.

[0067] Table 4

[0068]

[0069] According to the ISO 24443:2021 international standard, the external UVA protection factor and critical wavelength (for S1 to S2, C1 to C2 and P5)

[0070] This test is based on evaluating the UV transmittance of a film of a sunscreen product spread on a rough substrate using spectrophotometry. Helioplate SB6 sandblasted PMMA plates from HelioScreen Cosmetic Science SAS, lot number 498, were used. A standard amount of 1.2 mg / cm³ was dispensed using an automated dispenser. 2 (±1.5%) of the cosmetic formulation is applied to each substrate. The minimum application area and size is at least 22.1 cm². 2 Finally, allow the applied sunscreen to dry in the dark for at least 30 minutes but less than 60 minutes.

[0071] Measurements were performed before and after UV exposure to account for the potential photostability characteristics of the test product, the UV exposure using a specific measured and controlled dose of UV radiation from a defined UV exposure source. For this test, 25 J / cm² was applied.2 Pre-irradiation dose.

[0072] According to ISO / DIS 23675, the external SPF (sun protection factor) (for S1 to S2, C1 to C2 and P5)

[0073] This test assesses the UVB (ultraviolet-B) protection of sunscreen products based on UV spectral absorbance curves obtained through an in vitro procedure recommended by Cosmetics Europe [Annex I: Double Plate Method Protocol - COSMETICS EUROPE RECOMMENDATION N°26 ON THE USE OF ALTERNATIVE METHODS TO ISO24444:2019]. This in vitro procedure is currently underway at the ISO level under project ISO / DIS 23675 [ISO / DIS 23675 - Cosmetics – Sun protection test methods – In Vitro determination of Sun Protection Factor]. The results of this measurement procedure are used to calculate the Sun Protection Factor (SPF).

[0074] SPF in vitro assessment (for S3 to S7 and B1 to B2)

[0075] An internal-to-external method has been developed to calculate the SPF of sunscreen products against radiation that causes erythema. 体外 The protection factor (SPF) 体外 The value is calculated based on a set of standard sunscreens calibrated.

[0076] This method was developed based on the principles recommended by the European Cosmetics and Fragrance Association (formerly Colipa, now Cosmetics Europe) in 2011 (a protocol called the "In vitro SPF Double Plate method"), with internal modifications.

[0077] This test is based on the assessment of UV transmittance through a sunscreen sample film spread on a rough PMMA (poly(methyl methacrylate)) substrate. In a heuristic procedure, exposure to radiation from a UV exposure source is required. In this method, UV exposure is not used; each set of sunscreen transmittance data is mathematically corrected so that the in vitro SPF data produce the same SPF values ​​as provided by several certified SPF standards.

[0078] The absorbance A property of the sunscreen agent on the test panel was measured using a Perkin-Elmer LAMBDA1050+ UV / Vis / NIR spectrophotometer equipped with a 150 mm Perkin-Elmer LAMBDA integrating sphere module, and the SPF was calculated using the absorbance values ​​through the following integral formula:

[0079]

[0080] in:

[0081] E: CIE-1987 erythema response spectra listed in the table;

[0082] I: Global irradiance at midday summer at 40° North latitude listed in the table;

[0083] A: Measured absorbance;

[0084] C: Correction coefficient

[0085] The wavelength range of the UV spectrophotometer should span the main band of 290 nm to 400 nm, covering both the ranges of 290 nm to 320 nm (UV-B) and 320 nm to 400 nm (UV-A) required for SPF calculations.

[0086] The correction factor C is used in the calculation to make the SPF 体外 = SPF i，标准品 i = P1, P2, P3 (certified standard products in different sun protection ranges, see the table below for certification values).

[0087]

[0088] The average SPF improvement (%) calculated as follows is reported in the table below:

[0089]

[0090] in:

[0091] SPF B SPF measured for sample formulations containing UV filters and UV enhancers;

[0092] SPF F SPF measured for sample formulations containing UV filters;

[0093] SPF P SPF measured in placebo formulation (without UV filters and UV enhancers)

[0094] Table 5

[0095]

[0096] Table 5 clearly shows that the presence of the SPF enhancer based on microporous particles with a specific particle size distribution (PSD) of the present invention helps to enhance both UVB and UVA performance.

[0097] In fact, when an SPF enhancer characterized by a ratio of 0.1 to 5.0 between the second fraction and the sum of the first and third fractions (see samples S1 to S7) is used, the SPF enhancement is greater than 20%, and at the same time, the UVA-PF enhancement is improved by at least 10%.

[0098] Conversely, zeolite particles with higher ratios (see C1) did not achieve the desired increase in both UVB and UVA values. Meanwhile, typical UV synergists, such as silica particles characterized by a ratio of 0.01 reported in Comparative Example C2, showed that although they exhibited at least a 30% SPF synergistic effect, they did not significantly enhance the UVA-PF value.

[0099] SPF in vivo assessment

[0100] As further confirmation of the effectiveness of the invention, the formulation according to the invention was also tested in vivo according to the standard method of ISO 24444:2019 to evaluate the SPF of the sunscreen formulation. Ten healthy male and female subjects with skin phototypes I to III according to Fitzpatrick were recruited by committee-certified dermatologists.

[0101] Each subject's skin was partially exposed to UV light without any protection, while another (different) portion was exposed after application of the sunscreen to be tested. Yet another portion was exposed after application of a reference SPF sunscreen (for validation). To determine SPF, an incremental series of delayed erythema responses were induced at multiple small subsites on the skin. The presence of redness in these responses was visually assessed by trained technicians 20 ± 4 hours after UV exposure.

[0102] On the same day, the minimum erythema dose (MED) (MEDu) on unprotected skin and the MED (MEDp) obtained after application of the sunscreen product were determined for the same subject. The individual sun protection factor (SPFi) for each subject was calculated as the ratio of the individual MED on product-protected skin to the individual MED on unprotected skin, i.e., MEDp / MEDu. The product's sun protection factor (SPF) was the arithmetic mean of all valid SPFi results for each subject in the test.

[0103] If the 95% CI of the obtained mean SPF is within ±17% of the mean SPF, the test is considered valid for the top ten participants. If it is not within ±17% of the mean SPF, the number of participants is gradually increased from a minimum of 10 until the 95% CI statistical criterion is met.

[0104] Table 6. In vivo results

[0105]

Claims

1. A sunscreen composition comprising: a) at least one UV filter; and b) At least one SPF synergist, said SPF synergist being based on microporous particles with a particle size distribution (PSD) of 100 nm to 10 µm, said PSD comprising: - First fraction from 100 nm to 400 nm - The second fraction from 400 nm to 1 µm, and - The third fraction, from 1 µm to 10 µm, The characteristic feature is that the ratio of the amount of the second fraction to the sum of the first and third fractions is 0.1 to 5.

2. The composition according to claim 1, wherein the amount of SPF synergist particles is from 0.1% to 5% by weight relative to the total weight of the composition.

3. The composition according to claim 1 or 2, wherein the amount of the UV filter is from 1.0% to 35% by weight relative to the total weight of the composition.

4. The composition according to any one of the preceding claims, wherein the SPF synergist particles are characterized by a crystal structure with a crystallinity of more than 30%.

5. The composition according to any one of the preceding claims, wherein the SPF synergist particles are characterized by an aspect ratio of 0.1 to 1.

6. The composition according to any one of the preceding claims, wherein the SPF synergist particles are characterized by a refractive index of 1.35 to 1.

65.

7. The composition according to any one of the preceding claims, wherein the SPF synergist particles have a surface area of ​​200 m². 2 / g to 1000 m 2 It is made of inorganic materials per gram.

8. The composition according to claim 7, wherein the inorganic particles are zeolites characterized by orthorhombic or cubic cell structures.

9. The composition according to claim 8, wherein the zeolite is selected from octahedral zeolite (FAU), Linde type A (LTA), mordenite type (MOR), β-type zeolite, or a mixture of Linde type A (LTA) and ZSM-5 type zeolite.

10. The composition according to claims 1 to 5, wherein the SPF synergist particles have a surface area of ​​1000 m². 2 / g to 5000 m 2 It is made from organic materials per gram.

11. The composition according to claim 10, wherein the organic particles are a metal-organic framework, preferably cyclodextrin.

12. The composition according to any one of the preceding claims, wherein the UV filter is an organic molecule selected from the group consisting of: ethylhexyl hydroxybenzoyl benzoate, ethylhexyl salicylate, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazine ketone, phenylbenzimidazole sulfonic acid, occrylene, homolyl ester, butyl methoxydibenzoylmethane, trimethylcyclohexyl salicylate, ethylhexyl methoxycinnamate, benzophenone-3, ethylhexyl dimethyl p-aminobenzoic acid, benzophenone-4, triethanolamine salicylate, terephthalamide dicamphor sulfonic acid, cresoltrazolium trisiloxane, and 4-methyl Benzyl camphor polysiloxane-16, avobenzone, diethylhexylbutamidotriazine, tri-biphenyltriazine, tri-biphenyltriazine, oxybenzone, octyltriazine, octyl salicylate, pardimethicone O, bis-piperazine HAA299, (2-ethoxyethyl(2Z)-2-cyano-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-yl]acetate), sulphone, cresoltrazolium trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol, benzyl camphor sulfonic acid, 4-methylbenzyl camphor, polysiloxane-15, sulphone sodium, aminobenzoic acid, PEG-25 PABA, menthyl anthranilate, isopentyl-4-methoxycinnamate, dihydroxybenzone, cinnoxalate, camphor benzalkonium sulfate, or mixtures thereof.

13. The composition according to any one of the preceding claims, wherein the UV filter is an inorganic compound selected from zinc oxide, titanium dioxide, aluminum stearate, aluminum oxide, hydrated silica and aluminum hydroxide, mixtures thereof and surface-modified oxides.

14. The composition according to any one of the preceding claims, wherein the zeolite provides at least 20% SPF enhancement to the sunscreen composition.

15. The composition according to any one of the preceding claims further comprises an anhydrous phase selected from: oils, waxes, emollients, emulsifiers, silicones, polymers, esters, film-forming agents, solubilizers, organic and inorganic dispersants, rheology modifiers, fats, solvents and carriers, stabilizers, organic gelling components and inorganic gelling components.

16. The composition according to claim 15, wherein it is formulated as a stick, oil or gel.

17. The composition according to claims 1 to 15, wherein the composition is a uniform oil-in-water emulsion, preferably in the form of an essence or cream.

18. The composition according to any one of the preceding claims further comprises at least one of the following: cosmetically acceptable emollients, carriers, pigments, humectants, vitamins, antioxidants, emulsifiers, co-emulsifiers, hydrophilic or hydrophobic thickeners, waxes, lipids, film-forming agents, silicones, surfactants, activators, extracts, fragrances, preservatives, pH adjusters, suspending agents, and chelating agents.

19. The composition according to any one of the preceding claims, used as a sunscreen composition, preferably used in a method for protecting the stratum corneum from UV radiation, the method comprising contacting the stratum corneum with the composition.

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