Skincare compositions containing retinoid pigments that reduce odor

Abstract

A skin care composition for reducing odor. The skin care composition comprises a visual pigment and an aldehyde in a dermatologically acceptable carrier. The aldehyde may be a mixture of an unsaturated cyclic aldehyde having 11 carbon atoms and / or a straight-chain aldehyde having a chain length of about 4 to about 20 carbon atoms, alternatively about 8 to 11 carbon atoms.

Description

Technical Field

[0001] This disclosure relates generally to a stable skincare composition comprising visual pigments. More specifically, the present invention relates to a skincare composition comprising visual pigments in the form of an oil-in-water emulsion that reduces odor. Background Technology

[0002] Skincare products can improve the health and / or appearance of a user's skin. Currently, a diverse range of available topical skincare products are available, specifically formulated for acne management and anti-aging purposes. Many of these products aim to delay, minimize, or eliminate common signs of skin aging, including wrinkles, discoloration, and other histological changes caused by environmental damage or the natural aging process, to restore a younger and / or more vibrant appearance.

[0003] Many skincare products, including moisturizers and serums, may include vitamins, vitamin derivatives, and / or other active ingredients to improve the appearance of the skin. For example, vitamin A (also known as retinol) is known for its use in topical skincare compositions to provide beneficial effects on skin health and / or appearance. Vitamin A, along with its derivatives, forms a class of compounds commonly referred to as "retinoids." Retinoids were once primarily used to treat acne. More recently, they have also been used to treat photoaging and / or already aging skin.

[0004] However, formulating stable skincare products containing retinoids with an acceptable shelf life (e.g., 2+ years, preferably 3+ years) can be challenging because retinoids are undesirably reactive and readily degraded. Some known sources of degradation include oxidation, exposure (e.g., ultraviolet radiation), heat (e.g., temperatures of 40°C or higher), and interactions with other ingredients in the formulation. As retinoids degrade, their efficacy decreases, and the composition may yellow and develop a distinctly unpleasant odor reminiscent of yogurt.

[0005] In addition, some retinol products may contain preservatives and other formaldehyde-free ingredients designed to enhance the stability of retinoids. However, over time, the preservatives and other ingredients designed to enhance retinoid stability may develop an unpleasant odor. This can further contribute to the overall unpleasant odor of the formulation.

[0006] Therefore, there is a need to provide a skincare composition containing visual pigments that reduces odor. Specifically, a skincare composition containing visual pigments that reduces odor and has a preservative system free of formaldehyde releasers. Summary of the Invention

[0007] A skin care composition for reducing odor, the skin care composition comprising: (a) an unsaturated cyclic aldehyde having at least 11 carbon atoms; (b) a visual pigment; and (c) a dermatologically acceptable carrier.

[0008] A skin care composition for reducing odor, the skin care composition comprising: (a) a mixture of linear aldehydes, the mixture of linear aldehydes comprising: (i) a first linear aldehyde having a chain length of about 4 to about 20 carbon atoms; (ii) a second linear aldehyde having a chain length of about 4 to about 20 carbon atoms; wherein the chain lengths of the first aldehyde and the second aldehyde are different; (b) a visual pigment; and (c) a dermatologically acceptable carrier.

[0009] A skin care composition for reducing odor, the skin care composition comprising: (a) an odor-reducing material containing an aldehyde moiety; (b) a visual pigment; and (c) a dermatologically acceptable carrier. Attached Figure Description

[0010] Although this specification concludes by the claims that specifically point out and clearly claim protection for the subject matter of the invention, it is believed that the invention will be more readily understood from the following description taken in conjunction with the accompanying drawings, wherein:

[0011] Figure 1 Olay stored under ambient conditions is shown. ® Discrete data points and best-fit lines for the odor rating of Retinol 24 Moisturizing Cream and Example 1 over approximately 3 years;

[0012] Figure 2 This shows Olay products stored at 40°C for approximately 6 months. ® Discrete data points and best-fit lines for the odor rating of Retinol 24 Moisturizing Cream and Example 1 over approximately 3 years. Detailed Implementation

[0013] Retinoids are a class of compounds derived from vitamin A, often incorporated into skincare compositions for their anti-wrinkle, anti-acne, and anti-hyperpigmentation benefits. Formulating with retinoids is challenging due to their high tendency to degrade. Retinoids are sensitive to oxidation, hydrolysis, heat, and UV radiation. As retinoids degrade, fewer active ingredients are available for skin penetration, and the skincare product becomes less effective. Furthermore, the formulation may become noticeably yellower and may have an unpleasant odor reminiscent of yogurt.

[0014] In response to demands from some consumers and regulatory bodies, formaldehyde emitters can be removed from skincare products. For example, products previously containing DMDM ​​hydantoin (which can be used as a glycoside)... ® Commercially available) and DMDM ​​hydantoin and butylcarbamate iodopropynyl ester (can be used as Glydant) ®The preservative system used in Plus Liquid (commercially available) has been replaced with a formaldehyde-free alternative. The new preservative system incorporates cell wall disruptors such as phenoxyethanol and hydroxyacetophenone (available from Symrise). ® As Symsave ® (Originally obtained from H commercial sources), as well as antioxidants such as carnosine. This change ensures compliance with formaldehyde releaser elimination while maintaining product stability and effectiveness.

[0015] Qualified odor evaluators for Olay ® The Retinol 24+ Peptide Nighttime Facial Moisturizer and the sample from Example 1 in Table 1 below were graded. The moisturizer contains retinol, retinyl propionate, and DMDM ​​hydantoin preservative (LOT2081TN42). Example 1 contains retinyl propionate, preservative, and a visual pigment stabilizer, as well as phenoxyethanol, hydroxyacetophenone, carnosine, and sodium sulfite. Olay ® The Retinol 24 Moisturizing Cream was purchased approximately 17 months after its manufacture. Therefore, at the start of the evaluation (Day 0), these samples had undergone a 17-month aging period under typical conditions experienced during transport, warehousing, and display on store shelves. Odor evaluators graded each sample on a scale of 0 to 5 (integer values ​​only), with a rating of 5 representing the most favorable (i.e., no unpleasant odor present). A score of 3 or higher indicated that the composition was considered consumer-acceptable. However, even if the composition is considered consumer-acceptable, there is still a possibility of noticeable unpleasant odor. Under each condition, Olay... ® Retinol 24 moisturizing cream and Example 1 were each tested 13 times. Individual scores were combined and plotted to generate a curve representing the scent level over time. The best-fit model was used to generate... Figure 1 and Figure 2 The curve is drawn in the image. Note that due to overlapping data points, in... Figure 1 and Figure 2 There are fewer than 13 visible points in either of them.

[0016] Figure 1 The sample is shown at ambient temperature for approximately 3 years, and Figure 2 The sample exhibits accelerated stability conditions that have been subjected to 40°C for approximately 6 months. Figure 1 and Figure 2 The best-fit curves of both products showed that both retinol products developed more odor over time. However, there was an overall trend that Example 1, which contained phenoxyethanol, hydroxyacetophenone, sodium sulfite, and carnosine, had a lower odor rating, suggesting that including ingredients intended to improve formulation stability (including microhostility and retinoid stability) may lead to an increase in the severity of odor.

[0017] Certain aldehydes were found to reduce odor from the degradation of rhodopsin and also to help mitigate odor from other ingredients in the formulation. Table 5 below summarizes the fragrance evaluations conducted by three trained fragrance experts. Examples containing certain aldehydes, particularly 6-cyclopentylhexanal or straight-chain aldehydes with a chain length of 8 to 11 carbon atoms, reduced odor compared to controls.

[0018] Aldehydes may be contained in amounts such that they block odor but are low enough that consumers cannot perceive their presence in the formulation. The composition may contain about 0.00005% to about 0.05%, alternatively about 0.0001% to about 0.05%, alternatively about 0.0002% to about 0.05% of aldehydes. The composition may contain about 0.00005% to about 0.01%, alternatively about 0.0001% to about 0.0005%, alternatively about 0.0001% to about 0.0005%, alternatively about 0.0002% to about 0.0005%, alternatively about 0.00025% to about 0.0025%, and alternatively about 0.0002% to about 0.002% of aldehydes. The composition may contain about 0.00005% to about 0.05%, alternatively about 0.0001% to about 0.04%, alternatively about 0.0002% to about 0.03%, alternatively about 0.0004% to about 0.02%, and alternatively about 0.0005% to about 0.01% of an aldehyde.

[0019] Examples of aldehydes as effective odor blockers are unsaturated cyclic aldehydes having at least 8 carbon atoms, alternatively at least 9 carbon atoms, alternatively at least 10 carbon atoms, or alternatively at least 11 carbon atoms, particularly in the case of unsaturated cyclic aldehydes having 11 carbon atoms, where the carbon atoms can be in both cyclic and linear configurations, such as 6-cyclopentylhexanal. The cyclic moiety can be saturated. The cyclic moiety can have 5 to 7 members. The linear chain can have one degree of unsaturation. The linear chain can have about 7 to about 20 carbon atoms, alternatively about 9 to about 15 carbon atoms, and alternatively about 10 to about 13 carbon atoms.

[0020] Another example of an aldehyde as an effective odor blocker is a combination of straight-chain aldehydes having chain lengths of 4 to 20 carbon atoms (C4-C20), alternatively 6 to 16 carbon atoms (C6-C16), alternatively 7 to 14 carbon atoms (C7-C14), and alternatively 8 to 11 carbon atoms (C8-C11). The straight chain can be saturated. In some examples, only one aldehyde with a certain chain length is intentionally added. In another example, a mixture of aldehydes with different chain lengths is intentionally added. The mixture may contain a first aldehyde with a first carbon chain length, a second aldehyde with a second carbon chain length, an optional third aldehyde with a third carbon chain length, and an optional fourth aldehyde with a fourth carbon chain length. The first, second, third, and fourth chain lengths may all have different carbon chain lengths. The mixture may contain ≥10%, alternatively ≥15%, alternatively ≥17%, or alternatively ≥20% by weight of a first aldehyde, a second aldehyde, a third aldehyde (if present), and a fourth aldehyde (if present), by weight of the mixture. The mixture may contain ≤45%, alternatively ≤40%, alternatively ≤35%, or alternatively ≤30% by weight of a first aldehyde, a second aldehyde, a third aldehyde (if present), and a fourth aldehyde (if present), by weight of the mixture. The first, second, third, and / or fourth aldehyde may be present relative to another aldehyde in the composition in a weight ratio of about 1:2 to about 2:1, alternatively about 2:3 to about 4:2, alternatively about 3:4 to about 4:3, and alternatively about 4:5 to about 5:1.

[0021] Composition

[0022] The skincare composition may be monophase, or it may be an emulsion comprising a continuous phase and a dispersed phase. The skincare composition may contain a carrier, such as water, a polymer thickener, an antioxidant, a preservative system, an oil (including silicone oil), a visual pigment, and the odor-blocking technology described herein.

[0023] A dermatologically acceptable carrier enables the delivery of other components (e.g., active substances such as chromophores) to the skin at appropriate concentrations. Therefore, the carrier can act as a diluent, dispersant, solvent, etc., for particulate materials, helping to ensure that it can be applied to the selected target at an appropriate concentration and distributed uniformly on the selected target. The carrier may contain one or more dermatologically acceptable solid, semi-solid, or liquid fillers, diluents, solvents, extenders, etc. The carrier can be solid, semi-solid, or liquid. In some cases, the carrier may be inert or may provide its own beneficial effects to the keratinocytes. The concentration of the carrier may vary depending on the selected carrier and the desired concentration of the composition components.

[0024] The type of carrier used in the skincare compositions of this invention depends on the type of product form the composition is intended to produce. Topical compositions can be any cosmetic composition, such as moisturizers (including emulsions and creams), serums, gels, sticks, ointments, pastes, and mousses. These product forms may include several types of carriers, including but not limited to solutions, aerosols, emulsions, gels, solids, and liposomes.

[0025] Skincare compositions may be free of or formulated to be free of formaldehyde and formaldehyde releasers. Skincare compositions may be free of DMDM ​​hydantoin, imidazolidinyl urea, diazolidinyl urea, sodium hydroxyl, glycine methyl ester, and combinations thereof. Skincare compositions may also be free of parabens and / or sulfate-based surfactants (including SLS and SLES).

[0026] According to the color testing method described below, the composition may have a b value of less than 25, less than 20, less than 18, less than 14, alternatively less than 13, alternatively less than 12, alternatively less than 11, and alternatively less than or equal to 10.

[0027] Retinol compositions may comprise a preservative system acting as a cell wall disruptor, combined with an antioxidant and a reducing agent, as described below. The retinol composition may comprise a preservative system including hydroxyacetophenone, an antioxidant including carnosine, and a reducing agent including sodium sulfite, as shown and illustrated in U.S. Patent Application No. 18 / 460,804.

[0028] Preservative system

[0029] As used herein, a preservative system can be one or more substances and / or chemicals added to a cosmetic composition to prevent degradation caused by microbial growth and / or undesirable chemical changes. The preservative system may be formaldehyde-free and formaldehyde-releasing. In some examples, the preservative system may contain one or more ingredients that were registered as preservatives by the European Chemicals Agency (hereinafter referred to as the ECA) on 27 September 2022. In other examples, the preservative system may contain one or more ingredients that are not registered as preservatives by the ECA. Alternatively, the preservative system may be free of ingredients that are registered as preservatives by the ECA.

[0030] The composition may contain about 0.01% to about 1.5%, alternatively about 0.05% to about 1.25%, alternatively about 0.1% to about 1%, alternatively about 0.2% to about 0.8%, and alternatively about 0.3% to about 0.5% of a preservative system.

[0031] The preservative system may include one or more cell wall disruptors that inhibit microbial growth by disrupting the cell walls of microorganisms. Non-limiting examples of cell wall disruptors may include aromatic alcohols, medium-chain glycols, organic acids, hydroxyacetophenone, 1,2-hexanediol (and) octyl glycol, ethylhexylglycerol, methylheptylglycerol, or combinations thereof.

[0032] Non-limiting examples of aromatic alcohols may include phenoxyethanol, croterol, tyrosol, phenethyl alcohol, benzyl alcohol, or combinations thereof.

[0033] Non-limiting examples of medium-chain diols may include octyl glycol, pentylene glycol, hexanediol, or combinations thereof.

[0034] Non-limiting examples of organic acids may include benzoic acid, sorbic acid, levulinic acid, and salicylic acid, or combinations thereof.

[0035] Chelating agents

[0036] Cosmetic compositions may contain about 0.05% to about 0.5%, and alternatively about 0.1% to about 0.3%, of a chelating agent. As used herein, a "chelating agent" means an active agent capable of removing metal ions from a system by forming a complex that prevents metal ions from readily participating in or catalyzing a chemical reaction. Furthermore, chelating agents may be used in combination with the preservative systems described herein to enhance the efficacy of the preservatives. Non-limiting examples of chelating agents may include ethylenediaminetetraacetic acid (disodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate), tetrahydroxypropylethylenediamine, hydroxyethyl phosphate, sodium phytate, sodium phytate, oxalic acid and its derivatives, sodium gluconate, ethylenediaminedisuccinic acid (trisodium ethylenediaminedisuccinate), or combinations thereof.

[0037] antioxidants

[0038] The cosmetic composition may contain about 0.001% to about 1%, alternatively about 0.005% to about 0.85%, alternatively about 0.01% to about 0.75%, alternatively about 0.05% to about 0.5%, and alternatively about 0.1% to about 0.3% of an antioxidant.

[0039] Antioxidants can be non-vitamin antioxidants. Non-limiting examples of antioxidants may include hydroxycinnamic acid, ferulic acid, psoralen, tea extracts (including tea leaf extract (white tea) and green tea leaf extract), caffeine, rosemary leaf extract, octadecyl di-tert-butyl-4-hydroxyhydrocinnamate, carnosine, ethylene bis(oxyethylene)bis-(3-(5-tert-butyl-4-hydroxy-m-tolyl)propionate), pomegranate fruit extract, butylated hydroxytoluene (BHT), and L-ergothioneine (which can be used as THIOTANE). ™(obtained), tetrahydrocurcumin, hexadecylpyridinium chloride, diethylhexyl eugenol malonate (can be used as OXYNEX) ™ (Obtained), hexadecenoic acid (octadecenoic acid; from Uniqema's ARLATONE) ™ Dioic DCA, ubiquinone (coenzyme Q10), yeast extract or yeast culture (e.g., Piteraφ), or combinations thereof.

[0040] Antioxidants can be vitamin antioxidants. Non-limiting examples of vitamin antioxidants may include vitamin C, vitamin B (including niacinamide), vitamin D, vitamin E, vitamin K, or combinations thereof.

[0041] reducing agent

[0042] One or more reducing agents may be added to the composition to help reduce yellowing. The composition may contain about 0.01% to about 0.5%, alternatively about 0.02% to about 0.2%, and alternatively about 0.05% to about 0.1% of the reducing agent.

[0043] Non-limiting examples of reducing agents may include sulfites, acetylfarethrylcysteine, aminoethane sulfinic acid, butyrolactone thiol, dithionyl diacetate ethanolamine salt, ethyl mercaptoside, formamidinium sulfinic acid, hydrolyzed yeast / lactobacillus / ubiquinone enzyme, sodium glyoxylate, sodium hydroxymethanesulfonate, sodium formaldehyde bisulfite, sodium mercaptoacetate, sodium thiosulfate pentahydrate, sodium thiosulfate pentahydrate, potassium sulfite, sodium bisulfite, sodium metabisulfite, sodium thiosulfate, potassium metabisulfite, or combinations thereof.

[0044] Non-limiting examples of sulfites include sodium sulfite, potassium sulfite, ammonium bisulfite, ammonium sulfite, potassium metabisulfite, potassium sulfite, sodium bisulfite, sodium dithionite, sodium metabisulfite, or combinations thereof.

[0045] Dermatologically acceptable carriers

[0046] The compositions described herein include dermatologically acceptable carriers (which may be referred to as "carriers"). The phrase "dermatologically acceptable carrier" means that the carrier is suitable for topical application to keratinocytes, has good aesthetic properties, is compatible with the active substance in the composition, and does not cause any unreasonable safety or toxicity issues. In one embodiment, the carrier is present in an amount of about 50% to about 99%, about 60% to about 98%, about 70% to about 98%, or alternatively about 80% to about 95% by weight of the composition.

[0047] The carrier can take many forms. In some cases, the solubility or dispersion of the components (e.g., extracts, sunscreen active ingredients, additives) determines the form and characteristics of the carrier. Non-limiting examples include simple solutions (e.g., aqueous or anhydrous), dispersions, emulsions, and solid forms (e.g., gels, sticks, flowable solids, or amorphous materials). In some cases, dermatologically acceptable carriers are in the form of emulsions having a continuous aqueous phase (e.g., oil-in-water or water-in-oil-in-water emulsions) or a continuous oil phase (e.g., water-in-oil or water-in-oil-in-oil emulsions). The oil phase of the emulsion may contain silicone oils, non-silicone oils (such as hydrocarbon oils, esters, ethers), and mixtures thereof. The aqueous phase may contain water and water-soluble ingredients (e.g., water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other skin-care active ingredients). In some cases, the aqueous phase may contain components that are not water, including but not limited to water-soluble moisturizers, conditioning agents, antimicrobial agents, humectants, and / or other water-soluble skin-care active ingredients. In some cases, the non-aqueous components of the composition include wetting agents, such as glycerin and / or other polyols. The composition may contain about 1% to about 15%, alternatively about 3% to about 10%, alternatively about 4% to about 9%, and alternatively about 5% to about 8% of wetting agents.

[0048] In some cases, the compositions herein are in the form of an oil-in-water (“O / W”) emulsion that provides a mild and non-greasy sensory experience. Suitable O / W emulsions herein may comprise a continuous aqueous phase of greater than 50% by weight of the composition, with the remainder being a dispersed oil phase. The aqueous phase may comprise 1% to 99% water by weight, along with any water-soluble and / or water-miscible components. In these cases, the dispersed oil phase will typically be present at less than 40% by weight of the composition (e.g., 1% to 35%, 2% to 30%, 3% to 25%, 4% to 20%, or even 5% to 18%) to help avoid some undesirable sensory effects of oily compositions. The oil phase may comprise one or more volatile and / or non-volatile oils (e.g., vegetable oils, silicone oils, and / or hydrocarbon oils). Some non-limiting examples of oils suitable for use in the compositions of the present invention are disclosed in U.S. Patent No. 9,446,265 and U.S. Publication No. 2015 / 0196464.

[0049] The carrier may contain one or more dermatologically acceptable diluents. As used herein, “diluent” means a material in which the skincare active ingredient described herein can be dispersed, dissolved, or otherwise incorporated. Some non-limiting examples of hydrophilic diluents include water, organic hydrophilic diluents such as lower monovalent alcohols (e.g., C1-C4) and low molecular weight diols and polyols, including propylene glycol, polyethylene glycol (e.g., molecular weight from 200 g / mol to 600 g / mol), polypropylene glycol (e.g., Mw from 425 g / mol to 2025 g / mol), glycerin, butylene glycol, 1,2,4-butanetriol, sorbitan ester, 1,2,6-hexanetriol, ethanol, isopropanol, sorbitan ester, butylene glycol, ether propanol, ethoxylated ether, propoxylated ether, and combinations thereof.

[0050] Thickener

[0051] The composition may contain one or more thickeners, and alternatively at least two thickeners. In some examples, the composition is a moisturizing cream and may contain about 0.5% to about 6%, alternatively about 0.75% to about 5%, and alternatively about 1% to about 4% of a thickener. In other examples, the composition is a serum and may contain about 0.1% to about 4%, alternatively about 0.25% to about 3%, and alternatively about 0.5% to about 2% of a thickener. Suitable classes of thickeners include, but are not limited to, carboxylic acid polymers, polyacrylamide polymers, sulfonated polymers, copolymers thereof, hydrophobically modified derivatives thereof, and mixtures thereof.

[0052] The composition may contain a carboxylic acid polymer thickener, such as carbomer. The composition may contain about 0.1% to about 1%, alternatively about 0.2% to about 0.8%, alternatively about 0.25% to about 0.7%, alternatively about 0.3% to about 0.6%, and alternatively about 0.4% to about 0.5% of the carboxylic acid polymer thickener.

[0053] The composition may comprise a polyacrylamide polymer and a copolymer thickener. The composition may comprise about 0.8% to about 3%, alternatively about 0.9% to about 2.5%, alternatively about 1% to about 2.2%, alternatively about 1.1% to about 2.1%, alternatively about 1.2% to about 1.9%, or alternatively about 1.3% to about 1.8% of the polyacrylamide polymer and copolymer thickener.

[0054] Suitable thickeners include carboxylic acid polymers, such as carbomer (e.g., CARBOPOL). ® 900 series, such as CARBOPOL ® 954), and Ultrez 10 and Ultrez 30. Other suitable carboxylic acid polymerizers include acrylic acid C. 10-30A copolymer of an alkyl ester and one or more monomers, wherein the monomer is acrylic acid, methacrylic acid, or their short chains (i.e., C14-C ... 1-4 A short-chain ester of an alcohol ester, wherein the crosslinking agent is an allyl ether of sucrose or pentaerythritol. These copolymers are called acrylate / acrylate C 10-30 Alkyl ester crosslinked polymer, and in CARBOPOL ® 1342, CARBOPOL ® 1382, Ultrez 20, Ultrez 21, PEMULEN TR-1 and PEMULEN TR-2 were purchased from Noveon.

[0055] Other suitable thickeners include polyacrylamide polymers and copolymers. Exemplary polyacrylamide polymers have the CTFA designation "polyacrylamide, isoparaffin, and lauryl polyoxyethylene ether-7" and can be traded under the name SEPIGEL 305 from Seppic. ® The polymers are commercially available from the company (Fairfield, NJ). Other polyacrylamide polymers that may be used in this article include multiblock copolymers of acrylamide and substituted acrylamide with acrylic acid and substituted acrylic acid. Examples of commercially available multiblock copolymers include HYPAN SR150H, SS500V, SS500 W, and SSSA100H from Lipo Chemicals (Patterson, NJ).

[0056] Other suitable thickeners that can be used in this article are sulfonated polymers, such as sodium polyacrylamide dimethyl taurate (CTFA), which is available under the trade name Simulgel 800 from Seppic. ® The company and the product name Viscolam ® Purchased at 100 P from Lamberti SpA (Gallarate, Italy). Another commercially available material containing sulfonated polymers is purchased from Seppic. ® Sepiplus of the company ™ 400.

[0057] In addition, suitable thickeners may include superabsorbent polymers. These superabsorbent polymers may be selected from: cross-linked sodium polyacrylate, such as those from Avecia. ® Those sold under the names Octacare X100, X110, and RM100 are manufactured by SNF. ™ Those sold under the names Flocare GB300 and Flosorb 500 are manufactured by BASF. ®Those marketed under the names Luquasorb 1003, Luquasorb 1010, Luquasorb 1280, and Luquasorb 1100 are manufactured by Grain Processing. ® Those sold by the company under the names Water Lock G400 and G430 (INCI name: acrylamide / sodium acrylate copolymer), or Aqua Keep supplied by Sumitomo Seika. ® 10 SH NF, Aqua Keep ® 10 SH NFC, Sodium acrylate cross-linked polymer-2; made from acrylic polymers (homopolymers or copolymers), particularly starch grafted with sodium polyacrylate, such as those from Sanyo Chemical Industries. ® The company sells those under the names Sanfresh ST-100C, ST100MC, and IM-300MC, and supplies Makimouse 12 and Makimouse 25 (INCI name: sodium polyacrylate starch) from Kobo Products; hydrolyzed starch grafted onto acrylic polymers (homopolymers or copolymers), particularly acrylamide / sodium acrylate copolymers, such as those produced by Grain Processing. ® Those marketed under the names Water Lock A-240, A-180, B-204, D-223, A-100, C-200, and D-223 (INCI name: starch / acrylamide / sodium acrylate copolymer). Preferred superabsorbent polymers may include Makimousse 12 and Makimousse 25.

[0058] Thickeners suitable for use herein include gums. "Gum" is a term as broadly defined in the art. Gum includes gum arabic, agar, alginate, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimethylammonium chloride, lithium montmorillonite, hyaluronic acid, silica hydrate, hydroxypropyl deacetylated chitosan, hydroxypropyl guar gum, black privet gum, seaweed, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, their derivatives, and mixtures thereof.

[0059] Natural gums are polysaccharides of natural origin that can cause a significant increase in viscosity in solution, even at low concentrations. They can be used as thickeners, gelling agents, emulsifiers, and stabilizers. These gums are most commonly found in the lignin of plants or in seed coatings. Natural gums can be classified according to their origin. They can be classified as non-charged polymers or ionic polymers (polyelectrolytes), examples of which include the following: Natural gums obtained from seaweed, such as: agar; alginic acid; sodium alginate; and carrageenan. Natural gums obtained from non-marine plant resources include: gum arabic, from the sap of the acacia tree; solanum, from the sap of the elm tree (Anogeissus); tragacanth gum, from the sap of the astragalus shrub; and ebony gum, from the sap of the sterculia tree (Sterculia). Examples of uncharged gums include: guar gum, from guar beans; locust bean gum, from carob seeds; beta-glucan, from oat or barley bran; gum arabic, an older base for chewing gum obtained from the gum tree; dammar gum, from the sap of trees in the Dipterocarpaceae family; glucomannan, from the konjac plant; mastic gum, a chewing gum from the mastic tree originating in ancient Greece; plantain seed husk, from the plant Plantago; spruce gum, a chewing gum from the spruce tree originating in Indiana, USA; and tara gum, from the seeds of the tara tree. Natural gums produced by bacterial fermentation include gellan gum and xanthan gum.

[0060] Visual pigments

[0061] Skin care compositions may contain a safe and effective amount of retinoid pigments. As used herein, "retinoid pigments" include all natural and / or synthetic vitamin A or retinol analogs or retinol-like compounds having the biological activity of vitamin A in the skin, as well as geometric and stereoisomers of these compounds. For example, retinoid pigments may be retinol esters (e.g., C2-C of retinol). 22Alkyl esters, including retinyl palmitate, retinyl acetate, and retinyl propionate, retinal, retinal, β-carotene, and / or retinoic acid (including all-trans retinoic acid and / or 13-cis retinoic acid). A particularly suitable example of a retinoid used in the compositions of the present invention is retinyl propionate (“RP”). ​​These compounds are well known in the art and are commercially available from a variety of sources, such as Sigma Chemical Company (St. Louis, MO), Boerhinger Mannheim (Indianapolis, IN), BASF (Mt. Olive, NJ), and Roche (Basel, Switzerland). Other suitable retinoid pigments are tocopheryl retinoate (tocopheryl esters of retinoic acid (trans- or cis-), adapalene {6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid}, and tazolotine (6-[2-(4,4-dimethyldihydrobenzothiaran-6-yl)ethynyl]-nicotinic acid ethyl ester). Retinoid pigments may be included as pure or substantially pure material or as extracts obtained from natural (e.g., plant) sources by suitable physical and / or chemical separation methods.

[0062] The composition may contain 0.0001% to 2% (e.g., 0.005% to 2%, 0.01% to 1%, 0.01% to 0.5%, 0.1% to 0.4%, 0.15% to 0.3%) of a visual pigment. In some cases, a mixture of more than one visual pigment may be used.

[0063] The retinoid pigments present in the skincare compositions described herein may be stable. In order for the skincare compositions to provide the desired health or appearance benefits, it may be important to provide an appropriate amount of the retinoid pigment active substance.

[0064] The composition may have ≥70% RP remaining, alternatively ≥65% RP remaining, alternatively ≥60% RP remaining, alternatively ≥55% RP remaining, or alternatively ≥50% RP remaining at any time during the product's shelf life. %RP remaining is determined using the HPLC test method described below. Initial RP is the RP concentration at the time of manufacture, which may be present in the product packaging or other materials (e.g., website, SmartLabel). ® The required RP (etc.) is as follows.

[0065] silicone oil

[0066] The composition may contain silicone oil selected from volatile silicone oil, non-volatile silicone oil, and combinations thereof. The silicone oil may be in the dispersed phase. The composition may contain about 1% to about 35% silicone oil, alternatively about 5% to about 30% silicone oil, and alternatively about 10% to about 28% silicone oil.

[0067] Volatile silicone oil

[0068] Suitable volatile silicones may include cyclic and linear volatile silicones. Descriptions of various volatile silicones can be found in Todd et al., “Volatile Silicone Fluids for Cosmetics,” 91 Cosmetics and Toiletries 27-32 (1976). Suitable cyclic volatile silicones include cyclic dimethylsiloxane chains comprising an average of about 3 to about 5 silicon atoms, preferably about 4 to about 5 silicon atoms. Exemplary cyclic volatile silicones of different viscosities include Dow Corning DC 244, DC 245, DC 344, and DC345; GE Silicones-OSi Specialties Volatile Silicone 7207 and Volatile Silicone 7158; and GE Silicones SF1202. Suitable volatile linear silicones include polydimethylsiloxanes comprising an average of about 2 to about 8 silicon atoms. Exemplary linear volatile silicones include the DowCorning DC 200 series with viscosities of 0.65 cst, 1.0 cst, and 2.0 cst. In some embodiments, linear volatile silicones typically have a viscosity of less than or equal to about 4 centipoise at 25°C, and cyclic materials typically have a viscosity of less than about 6 centipoise at 25°C.

[0069] Non-volatile silicone oil

[0070] Suitable non-volatile silicone oils include polysiloxanes. Non-volatile polysiloxanes can have a viscosity of about 10 centistokes to about 1,000,000 centistokes at 25°C. Such polysiloxanes can be represented by the following general chemical formula:

[0071] R3SiO[R2SiO] x SiR3

[0072] Each R is independently selected from hydrogen or C1-30 straight-chain or branched, saturated or unsaturated alkyl, phenyl or aryl, trialkylsiloxy; and x is an integer from 0 to about 10,000. In some embodiments, R is methyl or ethyl. Commercially available polysiloxanes include polydimethylsiloxanes, also known as polydimethylsiloxanes, examples of which include the DM-Fluid series from Shin-Etsu and Vicasil sold by Momentive Performance Materials. ® The series and Dow Corning sold by Dow Corning Company ® 200 series. Specific examples of suitable polydimethylsiloxanes include Dow Corning. ® 200 fluid (also known as Xiameter) ® PMX-200 Silicone Fluids for sale). Suitable polydimethylsiloxanes include those represented by the following chemical formulas:

[0073] R3SiO[R2SiO] x [RR'SiO] y SiR3

[0074] R and R' are each independently hydrogen or C1-30 straight-chain or branched, saturated or unsaturated alkyl, aryl or trialkylsiloxy; and x and y are each integers from 1 to 1,000,000. Examples include alkyl polydimethylsiloxanes, wherein at least R' is an aliphatic alkyl group (e.g., C12-22). A suitable alkyl polydimethylsiloxane is cetyl polydimethylsiloxane, wherein R' is a C16 straight-chain and R is methyl, and is commercially available from Dow Corning as 2502Cosmetic Fluid.

[0075] Preferred non-volatile oils include polydimethylsiloxane (PDMS), preferably with a viscosity between 10 cst and 1000 cst, more preferably between 15 cst and 400 cst, and most preferably between 20 cst and 200 cst. These preferred PMS materials have an average chain length of about 12 to about 375 dimethylsiloxane units, more preferably about 20 to about 200 dimethylsiloxane units, and most preferably an average chain length of about 27 to about 125 dimethylsiloxane units. In one embodiment, the second composition will comprise at least one non-volatile silicone oil. In one such embodiment, at least about 70% by weight of the non-volatile oil is non-volatile silicone oil. In another embodiment, at least about 80% by weight of the non-volatile oil is non-volatile silicone. In yet another embodiment, at least about 90% by weight of the non-volatile oil is non-volatile silicone oil.

[0076] Other optional ingredients

[0077] The compositions of the present invention may optionally contain one or more additional ingredients commonly used in cosmetic compositions (e.g., colorants, skin-care active substances, anti-inflammatory agents, sunscreens, emulsifiers, buffers, rheology modifiers, combinations thereof, etc.), provided that the additional ingredient does not adversely alter the beneficial effects on skin health or appearance provided by the compositions of the present invention. When incorporated into the composition, the additional ingredients should be suitable for contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, etc. Other optional ingredients may be present in the continuous phase and / or dispersed phase. Some non-limiting examples of additional active substances include additional vitamins, minerals, peptides and peptide derivatives, glycosamines, sunscreens, oil-controlling agents, particles, flavonoids, hair growth regulators, antioxidants and / or antioxidant precursors, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizers, exfoliating agents, skin brighteners, sun-free tanning agents, lubricants, anti-acne active substances, anti-cellulite active substances, chelating agents, anti-wrinkle active substances, anti-atrophy active substances, phytosterols and / or phytohormones, N-acyl amino acid compounds, antimicrobial agents, and antifungal agents. In some examples, the composition may contain fragrances (especially natural fragrances and / or essential oils) or colorants (especially natural colorants). Other non-limiting examples of additional ingredients and / or skincare active substances applicable herein are described in U.S. Patent Publications 2002 / 0022040, 2003 / 0049212, 2004 / 0175347, 2006 / 0275237, 2007 / 0196344, 2008 / 0181956, 2008 / 0206373, 2010 / 00092408, 2008 / 0206373, 2010 / 0239510, and 2010 / 0189669. US Patent Nos. 2010 / 0272667, 2011 / 0262025, 2011 / 0097286, 2012 / 0197016, 2012 / 0128683, 2012 / 0148515, 2012 / 0156146 and 2013 / 0022557, and US Patent Nos. 5,939,082, 5,872,112, 6,492,326, 6,696,049, 6,524,598, 5,972,359 and 6,174,533.

[0078] When optional ingredients are included in the compositions herein, it may be desirable to select ingredients that do not form complexes or otherwise undesirably interact with other ingredients in the composition, particularly pH-sensitive ingredients such as nicotinamide, salicylates, and peptides. When present, optional ingredients may be included in amounts from 0.0001% to 50%; 0.001% to 20%; or even 0.01% to 10% (e.g., 50%, 40%, 30%, 20%, 10%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.1%) based on the weight of the composition. Optional ingredients, particularly fragrances, may be included in amounts from about 0.0001% to about 0.25%, alternatively from about 0.001% to about 0.1%, alternatively from about 0.005% to about 0.1%, and alternatively from about 0.01% to about 0.1%.

[0079] How to use

[0080] The skincare composition may be applied to the face, neck, and / or parts or combinations thereof at least once daily, twice daily, or more frequently daily during a treatment cycle. When applied twice daily, the first application should be at least 1 to 12 hours apart from the second. Typically, the composition is applied in the morning and / or at bedtime. The treatment cycle described herein is ideally the time during which the retinoid pigments and / or other skincare active substances are sufficient to improve the appearance of the skin. The treatment period may last at least one week (e.g., about 2, 4, 8, or even 12 weeks). In some cases, the treatment period may be extended to several months (i.e., 3 to 12 months). In some cases, the composition may be applied for most of the week (e.g., at least 4, 5, or 6 days per week), at least once daily or even twice daily during a treatment period of at least 2, 4, 8, or 12 weeks.

[0081] This skincare composition visibly improves fine lines and wrinkles, smoothness, radiance, firmness, dark spots, and pores. It also prevents rashes, blackheads, whiteheads, blemishes, and clogged pores. The composition restores skin tone and texture by clearing acne. It leaves skin feeling hydrated and revitalized. Apply this skincare composition at night. It evens out skin texture and minimizes the appearance of pores.

[0082] definition

[0083] As used in this article, “formulated as free” means that the ingredient was not intentionally added. However, “formulated as free” does not guarantee “100% free”, as trace amounts of contaminants are possible.

[0084] As used herein, “skincare” means conditioning and / or improving skin condition. Some non-limiting examples include improving the appearance and / or feel of skin by providing a smoother, more even look and / or feel; increasing the thickness of one or more layers of skin; improving skin elasticity or resilience; improving skin firmness; and reducing the oily, shiny, and / or dull appearance of skin; improving skin hydration or moisture levels; improving the appearance of fine lines and / or wrinkles; improving skin peeling or flaking; plumping the skin; improving skin barrier properties; improving skin tone; reducing the appearance of redness or rashes; and / or improving skin radiance, luminosity, or translucency; preventing skin damage, including damage caused by UV A and UV B, through antioxidant approaches; preventing acne formation; balancing the skin microbiome; or preventing acne.

[0085] As used herein, "skincare active ingredient" means a compound or combination of compounds that, when applied to the skin, provides acute and / or chronic beneficial effects to the skin or the cell types typically present therein. Skincare active ingredients can modulate and / or improve the skin or its associated cells (e.g., improve skin elasticity, hydration, skin barrier function, and / or improve cellular metabolism). In some examples, skincare active ingredients contain one or more visual pigments.

[0086] As used herein, "skincare composition" means a composition that contains skincare active ingredients and regulates and / or improves skin condition.

[0087] It should be understood that, as used herein, the terms “the,” “a,” or “an” mean “at least one” and should not be limited to “only one” unless explicitly indicated to the contrary. Thus, for example, unless the context otherwise clearly indicates, references to “a portion” include examples having two or more such portions.

[0088] The term “about” is used herein to indicate a difference from the stated figure by up to ±10%, such as ±9%, ±8%, ±7%, ±6%, ±5%, ±4%, ±3%, ±2%, or ±1%.

[0089] Unless otherwise specified, all percentages are by weight of the cosmetic composition. Unless otherwise specified, all ratios are by weight. All ranges are inclusive and combinable. Significant figures do not indicate any limitation on the quantities shown or on the accuracy of the measurement. All values ​​should be understood to be modified by the word “about” unless otherwise specified. Unless otherwise indicated, all measurements are understood to have been performed at approximately 21°C and ambient conditions, where “ambient conditions” means conditions at approximately 1 atmosphere and approximately 50% relative humidity. Unless otherwise specified, all weights related to the listed ingredients are based on active substance levels and do not include carriers or byproducts that may be contained in commercially available materials. All numerical ranges are narrower ranges including the ends; the upper and lower limits of the described ranges are interchangeable to further form ranges not explicitly described.

[0090] The compositions of the present invention may comprise, and optionally comprise, the basic components described herein, as well as optional ingredients, substantially comprising or consisting of them. As used herein, “substantially comprising” means that the composition or component may contain additional ingredients, provided that the additional ingredients do not substantially alter the essential and novel characteristics of the composition or method protected by the claims.

[0091] Test methods

[0092] Color testing methods

[0093] For the purposes of this invention, colors are defined according to values ​​on the CIELAB color system, which is based on the XYZ color system defined by the International Commission on Illumination (CIE system), to provide an objective way of representing perceived colors and color differences. X, Y, and Z can be represented in various ways or "scales," one of which is the Hunter scale. The Hunter scale has three variables, L, a, and b, which are mathematically related to X, Y, and Z, and are described by Robertson, AR, in "The CIE 1976 Color Difference Formulas," Color Research Applications, Vol. 2, pp. 7-11 (1977).

[0094] To measure the color of the compositions of the present invention, approximately 8 mL of the product to be tested was transferred to a covered petri dish (35 mm × 10 mm disposable covered petri dish) using a syringe. The covered petri dish was then placed on the black half of a standard opacity chart (Leneta (Manwah, NJ) N2A table or equivalent, with the upper half black and the lower half white). The color (L value, a value, and b value) of the product in the covered petri dish was then measured using an integrating sphere spectrophotometer, with a setting excluding specular reflection selected. The “a” value is correlated with the value along the red-green (horizontal) axis, and the “b” value is correlated with the value along the blue-yellow (vertical) axis. For example, a yellow sample will have a positive b-value, while a green sample will have a negative a-value. Larger positive or negative values ​​indicate a stronger color. The “L” value is an indicator of lightness and / or darkness and is correlated with the value along the z-axis, which measures both the horizontal and vertical axes.

[0095] HPLC testing method

[0096] This method provides a suitable approach for determining the amount of RP loss in a composition.

[0097] Place a sufficient quantity of the test composition in a controlled environment chamber / room at the desired temperature and humidity for the desired duration. When accelerated aging is complete, remove the sample from the controlled environment, equilibrate to room temperature (21°C ± 2°C) for 24 hours, and then measure it shortly thereafter for chemical analysis. Note that retinoids are photosensitizing and should not be exposed to direct light. Thoroughly mix all test compositions before sampling.

[0098] The amount of RP loss based on % wt / g is determined by HPLC (isocratic elution) as follows. Condition one or more HPLC columns according to standard operating procedures.

[0099] Chromatographic conditions

[0100] 1. Column: C18 (5 μm), 250 mm × 4.6 mm

[0101] 2. Mobile phase (eluent): Methanol / 2-propanol (70 / 30 v / v)

[0102] 3. Column temperature: approximately 25℃ (ambient temperature)

[0103] 4. UV wavelength: 280nm

[0104] 5. Injection volume: 20 μL

[0105] 6. Flow rate: 1.0 ml / min

[0106] 7. Running time: Approximately 22.0 minutes

[0107] 8. RP retention time: 6 minutes

[0108] mobile phase preparation

[0109] A 1 L mobile phase (elution buffer) was prepared by combining 700 mL of methanol with 300 mL of 2-propanol.

[0110] External standard preparation (prepared on the day of use)

[0111] In a 25 mL amber flask, dissolve 25 mg of retinyl propionate in 10 mL of mobile phase. Avoid exposing RP to light. Dilute to volume with mobile phase. Transfer 5.0 mL aliquots to a 50 mL amber flask and dilute to volume with mobile phase. Mix thoroughly. Filter approximately 1 mL of external standard into an amber HPLC vial through a suitable 0.45 μm filter (e.g., Whatman GD / X).

[0112] HPLC Sample Preparation

[0113] Using a 1cc tuberculin syringe, weigh 500 mg of the sample composition and transfer it to a 25 ml amber volumetric flask. Add 10 mL of mobile phase and vortex at high speed for 2 minutes or until the product is completely dispersed. Dilute to volume with the mobile phase and mix thoroughly. Filter approximately 1 ml into an autosampler vial using a syringe filter (e.g., a Whatman GD / X filter unit). Perform 20 injections using the conditions described.

[0114] (A) / (B)×(B) / (W)×(DF)×100=Retinyl Propionate, % by weight / weight

[0115] in,

[0116] A = Peak area of ​​retinyl propionate in the sample

[0117] B = Peak area of ​​retinyl propionate used for calibration

[0118] C = Standard weight of retinyl propionate, in mg

[0119] W = Sample weight, mg

[0120] DF = Dilution factor (e.g., 0.1)

[0121] Viscosity testing methods

[0122] After storing at 25°C for at least 24 hours, the product viscosity was measured at 25°C using a DV2T-RV viscometer (available from the Brookfield Engineering Laboratory, Middleborough, Massachusetts) with a TC spindle rotating at 5 rpm. The spindle began at 2.5 cm to 3.0 cm below the product surface and traveled a downward spiral path, collecting a reading every 9 seconds for 5 readings. The average of the readings (mean) was calculated to determine the average viscosity.

[0123] Example

[0124] The following data and examples are provided to help illustrate the skincare compositions described herein. The example compositions are given for illustrative purposes only and should not be construed as limiting the scope of this disclosure, as many variations are possible without departing from the spirit and scope of this disclosure. Unless otherwise specified, all parts, percentages, and ratios herein are by weight.

[0125] The examples in Table 1 illustrate skincare compositions prepared as follows: The aqueous phase component is added to a suitable mixing container and mixed until homogeneous. The oil phase component is added to a separate container and mixed until homogeneous. The oil phase is added to the aqueous phase and mixed using Tekmar... ® Grind the mixture for 2 to 3 minutes at 9000 to 11000 RPM using a TK-25 grinder or equivalent. Alternatively, use a propeller mixer instead of a grinder, and add the remaining materials (e.g., pH adjusters, feel / appearance modifiers such as starch and TiO2) and / or phases (if present) to the composition one at a time and continue mixing until homogeneous. Transfer the batch to a final container.

[0126] Table 1: Example 1

[0127]

[0128] Suppliers in Table 1:

[0129] 1. Sepigel ™ 305, from Seppic ® company

[0130] 2. Carbopol ® Ultrez 21 polymer, from Lubrizol ®

[0131] 3. Symsave ® H, from Symrise ®

[0132] 4. Pure-Dent ®From GPC ®

[0133] Table 2 below includes embodiments A through H, which contain Aqual ® Alternatively, a combination of straight-chain aldehydes with chain lengths between 8 and 11 carbons with those of Example 1 (see Table 1). Aqual ® (Available from Mane) ® It is 6-cyclopentylhexanal. It was found that very low levels of Aqual were required. ® To provide a beneficial effect from malodor, and in these embodiments, Aqual ® Delivery is made in a carrier fluid to help ensure uniform distribution throughout the composition. In Examples A through D, the carrier fluid is dipropylene glycol. The carrier fluid is not considered to provide any odor-causing beneficial effects.

[0134] Table 2

[0135]

[0136] Table 3 below shows the changes in viscosity and pH for Examples 1 (see Table 1) and Examples A through H (see Table 2) at the initial stage (i.e., shortly after sample preparation) and under accelerated stabilization conditions of 2 weeks at 60°C and 1 month at 40°C / 75% relative humidity. After each example was prepared, it was placed in a 2.5 oz glass wide-mouth bottle with a cap. All samples were placed in a large plastic container, which was placed in a suitable accelerated stabilization room and protected from light. Viscosity was measured according to the viscosity test methods described herein. The viscosity of an example was considered acceptable and stable if the change between the initial value and the value under both accelerated stabilization conditions did not exceed 30%. If the pH was greater than 5, the pH was considered acceptable and stable.

[0137] Table 3 compares the viscosity and pH of Examples A through G with that of Example 1 (control). The viscosity and pH values ​​of Examples A through G are similar to those of Example 1, and all of these examples fall within acceptable ranges. This indicates that the added aldehyde in the composition does not affect the stability of viscosity and pH.

[0138] Table 3

[0139]

[0140] Table 4 below shows the b-values ​​and residual retinyl propionate percentages at the initial stage (i.e., shortly after sample preparation) and under accelerated stability conditions. The b-values ​​were determined using the colorimetric method described herein. The residual retinyl propionate percentages were determined using the HPLC method described herein.

[0141] Table 4 compares the retinyl stability and yellowness of Examples A through G with Example 1 (control). The residual retinyl propionate percentages of Examples A through G are close to those of Example 1, and all examples fall within acceptable ranges. The b-values ​​of Examples A through G are also similar to those of Example 1, and the aldehydes do not exacerbate the yellowing of the products or have a substantial effect on pH. This indicates that the added aldehydes in the composition do not affect viscosity and pH stability.

[0142] Table 4

[0143]

[0144] The samples from Examples 1 and A through H were subjected to accelerated stability conditions by storing them at 60°C for two weeks. The samples were then evaluated by three trained fragrance experts who smelled the aged samples and provided their comments. The summarized evaluations are presented in Table 5 below. Based on the evaluation, Examples A through H were found to show improvement compared to the control (Example 1). These examples effectively addressed the base odor and are likely more consumer-acceptable than the control.

[0145] Table 5

[0146]

[0147] The controls, as well as Examples X and Y, listed in Table 6 below, were prepared using the same methods as those used for the examples in Table 1. Ten uninformed participants were tested, and 0.1 g of the controls, as well as Examples X and Y, were applied to the inner side of one forearm of each participant. Each participant was asked to rate the odor intensity using a 0-10 scale (0 for no odor, 10 for a strong odor) immediately after application (initial time point), 1.5 minutes after application, and 3 minutes after application.

[0148]

[0149] As shown in Table 6, compared with the control, those containing Aqual ® Both Examples X and Y exhibited lower odor intensity at all three time points. While both Examples X and Y may be consumer-acceptable, Example X is likely preferred because it exhibits lower odor intensity (Aqual). ® )aroma.

[0150] The examples in Table 7 can be prepared using the same methods used for the examples in Table 1.

[0151] Table 7

[0152]

[0153] Suppliers listed in Tables 1 and 6:

[0154] 1. Sepigel ™ 305, from Seppic ® company

[0155] 2. Carbopol ® Ultrez 21 polymer, from Lubrizol ®

[0156] 3. Symsave ® H, from Symrise ®

[0157] 4. Pure-Dent ® From GPC ®

[0158] 5. Aqual ® (Available from Mane) ® )

[0159] combination :

[0160] A. A skincare composition for reducing odor, the skincare composition comprising:

[0161] a. Aldehydes, including unsaturated cyclic aldehydes having 11 carbon atoms;

[0162] b. Visual pigments;

[0163] c. Dermatologically acceptable carriers.

[0164] B. A skincare composition for reducing odor, the skincare composition comprising:

[0165] a. Aldehydes, including mixtures of straight-chain aldehydes, the mixture of straight-chain aldehydes comprising:

[0166] i. A first straight-chain aldehyde comprising a chain length of about 4 to about 20 carbon atoms, preferably 6 to 16 carbon atoms, more preferably 7 to 14 carbon atoms, and even more preferably 8 to 11 carbon atoms;

[0167] ii. A second straight-chain aldehyde comprising a chain length of about 4 to about 20 carbon atoms, preferably 6 to 16 carbon atoms, more preferably 7 to 14 carbon atoms, and even more preferably 8 to 11 carbon atoms;

[0168] The chain lengths of the first aldehyde and the second aldehyde are different;

[0169] b. Visual pigments;

[0170] c. Dermatologically acceptable carriers.

[0171] C. The skincare composition according to paragraphs A to B, wherein the composition contains about 0.00005% to about 0.05%, preferably about 0.000075% to about 0.0025%, more preferably about 0.0001% to about 0.0015%, and even more preferably about 0.0001% to about 0.0005% of aldehydes.

[0172] D. The skincare composition according to paragraphs A and C, wherein the composition comprises about 0.00005% to about 0.015%, preferably about 0.0001% to about 0.01%, preferably about 0.0001% to about 0.001%, more preferably about 0.0002% to about 0.0005%, more preferably about 0.00025% to about 0.0025%, and even more preferably about 0.0002% to about 0.002% of an unsaturated cyclic aldehyde having 11 carbon atoms.

[0173] E. The skincare composition according to paragraphs A and C through D, wherein the unsaturated cyclic aldehyde comprises carbon atoms in both the cyclic configuration and the linear configuration.

[0174] F. The skincare composition according to paragraph E, wherein the linear configuration comprises about 7 to about 20 carbon atoms, preferably about 9 to about 15 carbon atoms, more preferably about 10 to about 13 carbon atoms, and even more preferably 5 to about 7 carbon atoms.

[0175] G. The skincare composition according to paragraphs E to F, wherein the linear configuration contains at least one degree of unsaturation, preferably exactly one degree of unsaturation.

[0176] H. The skincare composition according to paragraphs A and C through G, wherein the unsaturated cyclic aldehyde includes 6-cyclopentylhexanal.

[0177] I. The skin care composition according to paragraphs B to C, wherein the composition comprises a mixture of about 0.0001% to about 0.05%, preferably about 0.0003% to about 0.03%, more preferably about 0.0004% to about 0.02%, and even more preferably about 0.0005% to about 0.01% of the linear aldehyde.

[0178] J. The skincare composition according to paragraphs B to C and I, wherein the mixture of linear aldehydes comprises, by weight of the first linear aldehyde and the second linear aldehyde, ≥10%, preferably ≥15%, more preferably ≥17%, and even more preferably ≥20% by weight of the mixture.

[0179] K. The skincare composition according to paragraphs B to C and I to J, wherein the weight ratio of the first straight-chain aldehyde to the second straight-chain aldehyde is about 1:2 to about 2:1, preferably about 2:3 to about 4:2, more preferably about 3:4 to about 4:3 and even more preferably about 4:5 to about 5:1.

[0180] L. The skin care composition according to paragraphs B to C and I, wherein the mixture of linear aldehydes further comprises a third linear aldehyde having a chain length of about 4 to about 20 carbon atoms, preferably 6 to 16 carbon atoms, more preferably 7 to 14 carbon atoms and even more preferably 8 to 11 carbon atoms.

[0181] The chain length of the third straight-chain aldehyde is different from that of the first straight-chain aldehyde and the second straight-chain aldehyde.

[0182] M. The skincare composition according to paragraph L, wherein the mixture of linear aldehydes comprises ≥10%, preferably ≥15%, more preferably ≥17%, and even more preferably ≥20% of the third linear aldehyde by weight of the mixture.

[0183] N. The skincare composition according to paragraphs L to M, wherein the weight ratio of the first straight-chain aldehyde to the third straight-chain aldehyde is about 1:2 to about 2:1, preferably about 2:3 to about 4:2, more preferably about 3:4 to about 4:3 and even more preferably about 4:5 to about 5:1.

[0184] O. The skincare composition according to paragraphs L to N, wherein the carbon chain of the third linear aldehyde is saturated.

[0185] P. The skin care composition according to paragraphs L to O, wherein the mixture of linear aldehydes further comprises a fourth linear aldehyde, the fourth linear aldehyde having a chain length of about 4 to about 20 carbon atoms, preferably 6 to 16 carbon atoms, more preferably 7 to 14 carbon atoms and even more preferably 8 to 11 carbon atoms;

[0186] The chain length of the fourth straight-chain aldehyde is different from that of the first straight-chain aldehyde, the second straight-chain aldehyde, and the third straight-chain aldehyde.

[0187] Q. The skincare composition according to paragraph P, wherein the mixture of linear aldehydes comprises ≥10%, preferably ≥15%, more preferably ≥17%, and even more preferably ≥20% of the fourth linear aldehyde by weight of the mixture.

[0188] R. The skincare composition according to paragraphs P to Q, wherein the weight ratio of the first straight-chain aldehyde to the fourth straight-chain aldehyde is about 1:2 to about 2:1, preferably about 2:3 to about 4:2, more preferably about 3:4 to about 4:3 and even more preferably about 4:5 to about 5:1.

[0189] S. The skincare composition according to paragraphs L to R, wherein the carbon chain of the fourth linear aldehyde is saturated.

[0190] T. The skincare composition according to paragraphs B to C and I to S, wherein the carbon chains of the first straight-chain aldehyde and / or the second straight-chain aldehyde are saturated.

[0191] U. The skincare composition according to paragraphs A to T, wherein the composition is free of DMDM ​​hydantoin, imidazolidinyl urea, diazolidinyl urea, sodium hydroxyl and glycine methyl ester.

[0192] V. The skincare composition according to paragraphs A through U, wherein the composition further comprises a preservative system including hydroxyacetophenone; carnosine; and sodium sulfite.

[0193] W. The skincare composition according to paragraphs A through V further comprises one or more chelating agents selected from disodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, tetrahydroxypropyl ethylenediamine, hydroxyethyl phosphate, sodium phytate, phytic acid, oxalic acid and its derivatives, sodium gluconate, trisodium ethylenediaminedisuccinate, or mixtures thereof.

[0194] X. The skincare composition according to paragraphs A through W, wherein the visual pigment is selected from retinyl palmitate, retinyl acetate, retinyl propionate, or mixtures thereof.

[0195] Y. The skincare composition described in paragraphs A through X, wherein the skincare composition is free of formaldehyde and formaldehyde releasers.

[0196] Z. The skincare composition according to paragraphs A through Y, wherein the skincare composition is free of parabens and sulfate-based surfactants.

[0197] AA. The skincare composition according to paragraphs A to Z, wherein, according to the color testing method described herein, the skincare composition has a b value of less than 25, preferably less than 20, more preferably less than 14, and even more preferably less than or equal to 10.

[0198] BB. Use of the skin care composition according to any of the preceding claims for providing a retinol-containing composition that reduces odor.

[0199] The dimensions and values ​​disclosed herein should not be construed as strictly limited to the precise numerical values ​​cited. Rather, unless otherwise specified, each such dimension is intended to represent the stated value and a range of functionally equivalent values ​​around that value. For example, a dimension disclosed as “40 mm” is intended to represent “approximately 40 mm”.

[0200] Unless expressly excluded or otherwise limited, every reference cited herein, including any cross-references or related patents or patent applications, and any patent application or patent claiming priority to or benefiting from it, is incorporated herein by reference in its entirety. Reference to any reference is not an endorsement of it as prior art to any disclosed or protected art herein, nor is it an endorsement of any such invention, either on its own or in combination with any one or more references. Furthermore, where any meaning or definition of a term in this invention conflicts with any meaning or definition of the same term in referenced documents, the meaning or definition given to that term in this invention shall prevail.

[0201] While specific embodiments of the invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications falling within the scope of the invention be covered by the appended claims.

Claims

1. A skincare composition for reducing odor, said skincare composition comprising: a. Odor-reducing materials, wherein the odor-reducing materials are selected from... i. Materials containing aldehydes; ii. A material comprising a mixture of straight-chain aldehydes, said mixture of straight-chain aldehydes comprising:

1. A first straight-chain aldehyde, the first straight-chain aldehyde comprising a chain length of about 4 to about 20 carbon atoms; 2. A second straight-chain aldehyde, the second straight-chain aldehyde comprising a chain length of about 4 to about 20 carbon atoms; wherein the chain lengths of the first aldehyde and the second aldehyde are different; iii. or mixtures thereof; b. Visual pigments; and c. Dermatologically acceptable carriers.

2. The composition according to claim 1, wherein the composition comprises about 0.00005% to about 0.05%, preferably about 0.000075% to about 0.0025%, more preferably about 0.0001% to about 0.0015%, and even more preferably about 0.0001% to about 0.0005% of an odor-reducing material.

3. The skin care composition according to any of the preceding claims, wherein the odor-reducing material is unsaturated.

4. The skin care composition according to any of the preceding claims, wherein the odor-reducing material is a material comprising an aldehyde moiety, wherein the aldehyde moiety comprises cyclic aldehydes.

5. The skin care composition according to any of the preceding claims, wherein the cyclic aldehyde comprises at least 11 carbon atoms.

6. The skin care composition according to claims 4 to 5, wherein the cyclic aldehyde comprises carbon atoms in both a cyclic configuration and a linear configuration.

7. The skin care composition according to any of the preceding claims, wherein the unsaturated cyclic aldehyde comprises 6-cyclopentylhexanal.

8. The composition according to claims 1 to 3, wherein the odor-reducing material comprises a mixture of straight-chain aldehydes, wherein the mixture further comprises a third straight-chain aldehyde having a chain length of about 4 to about 20 carbon atoms; wherein the chain length of the third straight-chain aldehyde is different from the chain lengths of the first straight-chain aldehyde and the second straight-chain aldehyde.

9. The skin care composition according to any one of claims 1 to 3 and 8, wherein the first straight-chain aldehyde and the second straight-chain aldehyde comprise a carbon chain length of about 8 to about 11 carbon atoms.

10. The skincare composition according to any one of claims 1 to 3 and 8 to 9, wherein the mixture of linear aldehydes comprises ≥10% of the first linear aldehyde by weight of the mixture, preferably ≥15% of the first linear aldehyde by weight of the mixture, more preferably ≥17% by weight of the mixture, and even more preferably ≥20% by weight of the mixture.

11. The skin care composition according to any of the preceding claims, wherein the composition is free from DMDM ​​hydantoin, imidazolidinyl urea, diazolidinyl urea, sodium hydroxyl and glycine methyl ester.

12. The skin care composition according to any of the preceding claims, wherein the composition further comprises a preservative system including hydroxyacetophenone; carnosine; and sodium sulfite.

13. The skincare composition according to any of the preceding claims, wherein the skincare composition further comprises one or more chelating agents selected from disodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, tetrahydroxypropyl ethylenediamine, hydroxyethyl phosphate, sodium phytate, phytic acid, oxalic acid and its derivatives, sodium gluconate, trisodium ethylenediaminedisuccinate, or mixtures thereof.

14. The skin care composition according to any of the preceding claims, wherein the retinoid pigment is selected from retinyl palmitate, retinyl acetate, retinyl propionate, or mixtures thereof.

15. Use of the skin care composition according to any of the preceding claims for providing a retinol-containing composition that reduces odor.

Images