A cockroach luring slow-release tablet and a preparation method and application thereof

Abstract

The application provides a cockroach luring slow-release tablet and a preparation method and application thereof, and creatively adopts a wet granulation and tabletting process to prepare a tablet with low moisture and high density, the tablet has excellent mechanical strength and thermal stability, is not easy to be broken during transportation, and is not easy to deteriorate during normal-temperature storage; a three-level slow-release system of "micelle-gel-skeleton" is constructed, and the release of effective components needs to overcome multiple barriers; experimental data show that the tablet can stably release 96.55% of the effective components within 120 days, and no burst release phenomenon occurs, waste of pheromones is avoided, long-term stable luring of the cockroaches is realized, the release curve is gentle, and the effective period is long.

Description

Technical Field

[0001] This invention relates to the field of pest control technology, specifically to a cockroach-attracting slow-release tablet, its preparation method, and its application. Background Technology

[0002] Cockroaches are a common urban pest, carrying various pathogens that can transmit diseases such as dysentery, typhoid fever, and hepatitis. Their secretions and excrement can also trigger allergic reactions in humans. Cockroaches reproduce rapidly, have a varied diet, and are highly secretive, making them extremely difficult to eradicate once they establish themselves in residential areas, hotels, restaurants, hospitals, and other similar environments. Currently, chemical control remains the primary method for controlling cockroach populations. Products such as cockroach traps, sticky traps, and gel baits, which use attractants, are widely popular due to their ease of use, environmental friendliness, and lack of exposure to volatile pesticides.

[0003] The attractant is the core functional component of the above products, and its performance directly determines the capture or extermination effect. Traditional cockroach attractants mostly use food-based ingredients such as starch, brown sugar, maltose, and oil as the basic attractant materials. However, these food-based attractants have the following inherent defects: (1) poor stability, easy to get damp and clump, mold and deteriorate, especially in hot and humid seasons or humid environments (such as kitchens and sewers), their effective period is shortened sharply; (2) different dietary preferences for different types of cockroaches (such as German cockroaches, American cockroaches, and black-breasted cockroaches) are very different, making it difficult to achieve broad-spectrum and efficient attraction; (3) it is a passive attraction, cockroaches need to eat before it can exert an attraction effect, and eating itself is not a necessary behavior for cockroaches to search for habitats or mating places, so the attraction effect is limited; (4) when exposed to the air for a long time, the fragrance components are easy to evaporate and dissipate, resulting in a rapid decline in attraction activity.

[0004] To address these issues, researchers have recently focused on using cockroach pheromones as attractants. Pheromones are natural chemical substances secreted by cockroaches that function as intraspecific signal transduction agents. For example, benzyl benzoate is considered an aggregation pheromone component in many cockroach species, capable of inducing aggregation, dwelling, and foraging behaviors, offering advantages such as high specificity, low dosage, and stable effects. However, pheromones are typically lipid-soluble, volatile small-molecule compounds. Developing them into commercially viable solid formulations with long-lasting, stable release remains a significant technical challenge.

[0005] Several methods have been explored in the existing technology for preparing pheromone solid dosage forms. For example, using adsorbents (such as diatomaceous earth and activated carbon) to adsorb pheromones followed by direct filling or tableting is a simple process, but the release rate is difficult to control due to the weak physical adsorption between pheromone molecules and the carrier, easily leading to a burst release phenomenon. This results in a significant loss of the active ingredient within a short period, often with a duration of effect of less than 30 days. Another method involves dissolving pheromones in organic solvents and then spraying or impregnating them onto the surface of a porous carrier. This method also carries the risk of solvent residue, and the release curve is uncontrollable.

[0006] Another common technical approach involves mixing pheromones with polymers (such as polyethylene, polyvinyl chloride, rubber, and waxes) and then molding them through melt extrusion or casting. While these formulations delay pheromone release to some extent, their preparation typically requires exposing the pheromones to high temperatures (often exceeding 80°C), which can easily cause the decomposition or isomerization of heat-sensitive pheromone components, reducing product activity. More importantly, these polymer or wax matrices themselves are not biodegradable, leaving residues in the environment and causing secondary pollution after use. Furthermore, some existing technologies attempt to use hydrophilic gel materials (such as gelatin and sodium alginate) combined with water and glycerin to create gel-type pheromone formulations, aiming to control release through a gel network. However, these types of gel formulations have serious inherent problems: First, the high water content (usually exceeding 20%) and the addition of large amounts of glycerin as a humectant cause the formulation to remain moist for extended periods, resulting in a sticky surface, difficulty in demolding, and susceptibility to microbial contamination and mold growth during storage and transportation. Second, the presence of glycerin makes the formulation extremely sensitive to temperature; even slightly elevated ambient temperatures (such as 50-60°C in a closed vehicle during summer) cause softening, deformation, or even flow, leading to loss of the formulation's geometric shape and release function. Third, the gel material has extremely low mechanical strength, breaking easily under slight external force, making it unsuitable for conventional packaging, transportation, and application scenarios. Therefore, although these gel formulations can be prepared on a laboratory scale, they are almost entirely unfeasible for industrialization and commercialization.

[0007] In addition, existing technologies also include the method of simply mixing pheromones with surfactants to form an emulsion and then adsorbing it onto a carrier. However, such methods only achieve the initial solubilization and dispersion of pheromones and fail to build an effective multi-level sustained-release barrier. The pheromone release rate is still too fast, and the emulsion itself is unstable and prone to phase separation.

[0008] In summary, the existing technology lacks a solid cockroach attractant formulation that can simultaneously meet the following requirements: (1) the formulation itself has excellent mechanical strength and thermal stability, and does not soften, absorb moisture, or break during storage and transportation at room temperature or even higher temperatures; (2) it can achieve long-term and stable release of pheromones, with a duration of effect of more than 3 months; (3) the preparation process is mild and does not damage the active ingredients of the pheromones; and (4) it has good environmental compatibility and is easy to handle after use. This invention is proposed to address the above-mentioned technical problems. Summary of the Invention

[0009] The purpose of this invention is to overcome the shortcomings and deficiencies of the existing technology and to provide a cockroach-attracting slow-release tablet, its preparation method and application.

[0010] The technical solution adopted in this invention is as follows: The first aspect of the present invention provides a cockroach attractant slow-release tablet prepared from raw materials comprising the following components by weight percentage: Active ingredient 1% - 10%; Surfactant 0.5% - 5%; Fragrance fixative 0.5% - 2%; Skeleton material 30% - 60%; Adhesive 2% - 6%; The rest is water; The active ingredient includes cockroach pheromones and / or fragrance enhancers, and the skeletal material includes at least one of calcium carbonate, mannitol, common starch, dicalcium phosphate, and microcrystalline cellulose. The tablets are prepared by forming a micelle emulsion with the active ingredient, a surfactant, a flavor fixative, and water, then mixing the micelle emulsion with a matrix material, followed by wet granulation, drying, and tableting.

[0011] Preferably, the cockroach pheromone includes at least one of benzyl benzoate, 4-butyloctyl alcohol, 1-octen-3-ol acetate, cyclohexyl propionate, verbenaenoyl acetate, and isoborneol acetate, and the fragrance enhancer includes at least one of methylcyclopentenolone, 1-hexanol, propylene glycol, 1,3-dihydroxyacetone, 2-amino-3-methylbutyric acid, and methylcyclopentenolone.

[0012] Preferably, the adhesive comprises polyvinylpyrrolidone; the fragrance fixative is selected from at least one of modified starch, β-cyclodextrin, polyethylene glycol, and gelatin, wherein the modified starch is selected from at least one of carboxymethyl starch, pregelatinized starch, and octenyl succinate starch ester.

[0013] Preferably, the surfactant is selected from at least one of sodium stearate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, fatty alcohol polyoxyethylene ether, and decaethylene glycol monododecyl ether.

[0014] A second aspect of the present invention provides a method for preparing the above-mentioned cockroach-attracting sustained-release tablets, comprising the following steps: S1. Mix the fixative, surfactant, active ingredient and water in proportion, and heat and stir until a uniform and stable micelle emulsion is formed; S2. Add the skeleton material to the micelle emulsion and mix evenly, then add the adhesive and continue mixing until a moist soft material is formed; S3. The soft material is granulated into wet granules using a granulator, and then dried to obtain dry granules; S4. Compress the dry granules into tablets to obtain the cockroach-attracting sustained-release tablets.

[0015] Preferably, in step S1, the heating temperature is 50-60℃.

[0016] Preferably, in step S3, the drying temperature is 40-60℃.

[0017] Preferably, in step S3, the particle size of the wet particles is 0.6-0.8 mm.

[0018] Preferably, in step S4, the tableting pressure is 40-80 kN.

[0019] A third aspect of the present invention provides the use of the above-described cockroach-attracting slow-release tablets or cockroach-attracting slow-release tablets prepared by the above-described method in the preparation of cockroach trapping devices or cockroach-attracting products.

[0020] The beneficial effects of this invention are as follows: 1. This invention abandons the existing approach of relying on low-melting-point fat coagulation or high-water-content gel shaping, and creatively adopts a wet granulation and tableting process to prepare low-moisture, high-density tablets. These tablets possess excellent mechanical strength and thermal stability, are not easily broken during transportation, and are not easily deteriorated when stored at room temperature.

[0021] 2. This invention constructs a three-stage sustained-release system of "micelles-gel-skeleton," where the release of the active ingredient requires overcoming multiple barriers. Experimental data show that the tablets of this invention can stably release 96.55% of the active ingredient within 120 days, without burst release, avoiding the waste of pheromones, achieving long-term stable attraction of cockroaches, with a smooth release curve and long-lasting effect.

[0022] 3. This invention uses a specific combination of benzyl benzoate (pheromone) and methylcyclopentenolone (fragrance enhancer) to achieve synergistic effects and has a strong attraction effect on a variety of cockroaches, overcoming the shortcomings of traditional food-based attractants that are not attractive enough to different types of cockroaches.

[0023] 4. The preparation method of the present invention has strong equipment versatility, good controllability of process parameters, and is easy to realize industrial production and quality control. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, obtaining other drawings based on these drawings without creative effort still falls within the scope of the present invention.

[0025] Figure 1 This is the standard curve of active ingredient release used in the embodiments of the present invention; Figure 2 This is a residual rate curve for Embodiment 1 and Comparative Example 1 of the present invention. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings.

[0027] Example 1 This embodiment provides a cockroach-attracting sustained-release tablet and its preparation method. The formulation of the cockroach-attracting sustained-release tablet in this embodiment is as follows: Gelatin: 0.910% Light calcium carbonate: 25.39% Microcrystalline cellulose: 25.39% 12 wt% polyvinylpyrrolidone aqueous solution: 34.14% Sodium dodecyl sulfate (SDS): 1.13% Active ingredient (benzyl benzoate: methylcyclopentenolone = 9.29:0.49): 4.84% The sum of all components is 100%.

[0028] The preparation method of the cockroach-attracting sustained-release tablets in this embodiment includes the following steps: (1) Weigh 10g solid gelatin, 12.51g SDS, 9.29g benzyl benzoate and 0.49g methylcyclopentenolone, add 90g deionized water, place the mixture in a water bath and heat to 55°C, stirring constantly to form a uniform micelle emulsion.

[0029] (2) Weigh 55.18g of light calcium carbonate and 55.18g of microcrystalline cellulose and stir to premix. Use a dropper to take 18.38g of the micelle emulsion prepared in step (1) and add it to the premixed powder and mix evenly.

[0030] (3) Add 68.98g of 12wt% polyvinylpyrrolidone aqueous solution in batches and stir quickly to mix it evenly until the material becomes a moist soft material that can be clumped together when squeezed and dispersed when touched, and in the form of millet-shaped wet granules.

[0031] (4) Use a granulator to make wet granules with a particle size of 0.6-0.8 mm, place them in a forced-air drying oven, and dry them at 50°C until the moisture content is less than 5%.

[0032] (5) Add an appropriate amount of microcrystalline cellulose powder (as an external disintegrant / lubricant, optional step) to the dried granules, mix evenly, and press into tablets using a rotary tablet press under a pressure of 60 kN to obtain the tablet sample of Example 1. The average hardness of the obtained tablets is 104.2 N.

[0033] Example 2 This embodiment provides a cockroach-attracting sustained-release tablet and its preparation method. The formulation of the cockroach-attracting sustained-release tablet in this embodiment is as follows: Octenyl succinate starch ester: 9.10% Light calcium carbonate: 25.39% Microcrystalline cellulose: 25.39% 12 wt% polyvinylpyrrolidone aqueous solution: 34.14% Sodium dodecyl sulfate: 1.13% Active ingredient (benzyl benzoate: methylcyclopentenolone = 9.29:0.49): 4.84% The sum of all components is 100%.

[0034] The preparation method of the cockroach-attracting sustained-release tablets in this embodiment includes the following steps: (1) Weigh 30g of octenyl succinate starch ester, 12.51g of SDS, 9.29g of benzyl benzoate and 0.49g of methylcyclopentenolone, add 70g of deionized water, place the mixture in a water bath and heat to 70°C, and stir continuously to form a uniform micelle emulsion.

[0035] (2) Weigh 55.18g of light calcium carbonate and 55.18g of microcrystalline cellulose and stir to premix. Use a dropper to take 18.38g of the micelle emulsion prepared in step (1) and add it to the premixed powder and mix evenly.

[0036] (3) Add 68.98g of 12wt% polyvinylpyrrolidone aqueous solution in batches and stir quickly to mix it evenly until the material becomes a moist soft material that can be clumped together when squeezed and dispersed when touched, and in the form of millet-shaped wet granules.

[0037] (4) Use a granulator to make wet granules with a particle size of 0.6-0.8 mm, place them in a forced-air drying oven, and dry them at 50°C until the moisture content is less than 5%.

[0038] (5) Add an appropriate amount of microcrystalline cellulose powder (as an external disintegrant / lubricant, optional step) to the dried granules, mix thoroughly, and press into tablets using a rotary tablet press under a pressure of 60 kN to obtain the tablet sample of Example 2. The average hardness of the obtained tablets is 103.5 N.

[0039] Example 3 This embodiment provides a cockroach-attracting sustained-release tablet and its preparation method. The formulation of the cockroach-attracting sustained-release tablet in this embodiment is as follows: Polyethylene glycol: 9.10% Light calcium carbonate: 25.39% Microcrystalline cellulose: 25.39% 12 wt% polyvinylpyrrolidone aqueous solution: 34.14% Fatty alcohol polyoxyethylene ether: 1.13% Active ingredient (benzyl benzoate: 1-hexanol = 9.29:0.49): 4.84% The sum of all components is 100%.

[0040] The preparation method of the cockroach-attracting sustained-release tablets in this embodiment includes the following steps: (1) Weigh 10g polyethylene glycol, 12.51g fatty alcohol polyoxyethylene ether, 9.29g benzyl benzoate and 0.49g 1-hexanol, add 90g deionized water, place the mixture in a water bath and heat to 60°C, and stir continuously to form a uniform micelle emulsion.

[0041] (2) Weigh 55.18g of light calcium carbonate and 55.18g of microcrystalline cellulose and stir to premix. Use a dropper to take 18.38g of the micelle emulsion prepared in step (1) and add it to the premixed powder and mix evenly.

[0042] (3) Add 68.98g of 12wt% polyvinylpyrrolidone aqueous solution in batches and stir quickly to mix it evenly until the material becomes a moist soft material that can be clumped together when squeezed and dispersed when touched, and in the form of millet-shaped wet granules.

[0043] (4) Use a granulator to make wet granules with a particle size of 0.6-0.8 mm, place them in a forced-air drying oven, and dry them at 50°C until the moisture content is less than 5%.

[0044] (5) Add an appropriate amount of microcrystalline cellulose powder (as an external disintegrant / lubricant, optional step) to the dried granules, mix evenly, and press into tablets using a rotary tablet press under a pressure of 60 kN to obtain the tablet sample of Example 3. The average hardness of the obtained tablets is 103.7 N.

[0045] Example 4 This embodiment provides a cockroach-attracting sustained-release tablet and its preparation method. The cockroach-attracting sustained-release tablet in this embodiment... The formulation of the agent is as follows: β-Cyclodextrin: 9.10% Light calcium carbonate: 25.39% Microcrystalline cellulose: 25.39% 12 wt% polyvinylpyrrolidone aqueous solution: 34.14% Fatty alcohol polyoxyethylene ether: 1.13% Active ingredient (cyclohexyl propionate: 1-hexanol = 9.29:0.49): 4.84% The sum of all components is 100%.

[0046] The preparation method of the cockroach-attracting sustained-release tablets in this embodiment includes the following steps: (1) Weigh 10g of β-cyclodextrin, 12.51g of fatty alcohol polyoxyethylene ether, 9.29g of cyclohexyl propionate and 0.49g of 1-hexanol, add 90g of deionized water, place the mixture in a water bath and heat to 50°C, stirring constantly to form a uniform micelle emulsion.

[0047] (2) Weigh 55.18g of light calcium carbonate and 55.18g of microcrystalline cellulose and stir to premix. Use a dropper to take 18.38g of the micelle emulsion prepared in step (1) and add it to the premixed powder and mix evenly.

[0048] (3) Add 68.98g of 12wt% polyvinylpyrrolidone aqueous solution in batches and stir quickly to mix it evenly until the material becomes a moist soft material that can be clumped together when squeezed and dispersed when touched, and in the form of millet-shaped wet granules.

[0049] (4) Use a granulator to make wet granules with a particle size of 0.6-0.8 mm, place them in a forced-air drying oven, and dry them at 50°C until the moisture content is less than 5%.

[0050] (5) Add an appropriate amount of microcrystalline cellulose powder (as an external disintegrant / lubricant, optional step) to the dried granules, mix evenly, and press into tablets using a rotary tablet press under a pressure of 60 kN to obtain the tablet sample of Example 4. The average hardness of the obtained tablets is 104.0 N.

[0051] Comparative Example 1 This comparative example provides a cockroach attractant tablet that does not contain gelatin or surfactant (SDS) and its preparation method. The formulation of the cockroach attractant sustained-release tablet in this comparative example is as follows: formula: Light calcium carbonate: 25.39% Microcrystalline cellulose: 25.39% 12 wt% polyvinylpyrrolidone aqueous solution: 34.14% Deionized water (in place of gelatin aqueous solution and SDS solution): 9.10% Active ingredient (benzyl benzoate: methylcyclopentenolone = 9.29:0.49): 4.84% The sum of all components is 100%.

[0052] The preparation method of the cockroach-attracting sustained-release tablets in this comparative example includes the following steps: (1) Mix the active ingredients (benzyl benzoate and methylcyclopentenolone) with 9.10 g of deionized water and stir simply at room temperature to form an oil-water two-phase mixture (it cannot form a stable emulsion and separates into layers after standing).

[0053] (2) Weigh 55.18g of light calcium carbonate and 55.18g of microcrystalline cellulose, and stir to premix. Add the oil-water mixture from step (1) to the premixed powder and mix evenly.

[0054] (3) Add 68.98g of 12wt% polyvinylpyrrolidone aqueous solution in batches and stir quickly to mix it evenly until the material becomes a moist soft material.

[0055] (4) Use a granulator to form wet granules with a particle size of 0.6-0.8 mm, place them in a forced-air drying oven, and dry them at 50°C until the moisture content is less than 5%.

[0056] (5) Add an appropriate amount of microcrystalline cellulose powder to the dry granules, mix, and press into tablets under a pressure of 60 kN to obtain the tablet sample of Comparative Example 1. The average hardness of the obtained tablets is 104.2 N.

[0057] Comparative Example 2 This comparative example provides a cockroach attractant tablet prepared by melt casting and its preparation method. The formulation of the cockroach attractant sustained-release tablet in this comparative example is as follows: Pure insect sex pheromone (replaced with benzyl benzoate): 5.21% (i.e., the active ingredient) Fatty compounds (glyceryl arborescens: natural beeswax = 1:2): 15.0% Gel matrix material (gelatin): 15.0% Glycerin: 25.0% Deionized water: 30.0% Inert powder (attapulgite powder): 9.79% The preparation method of the cockroach-attracting sustained-release tablets in this comparative example includes the following steps: (1) Heat 50.0g of glyceryl benzoate and 100.0g of natural beeswax to 70℃±5℃, mix and melt them, then add 52.1g of active ingredients (benzyl benzoate + methylcyclopentenolone) and mix evenly to prepare a solid dispersion.

[0058] (2) Mix 150g gelatin, 250g glycerin and 300g water at 70℃±5℃ until completely dissolved to prepare a gelatin gel matrix.

[0059] (3) The above solid dispersion, gelatin gel matrix and 97.9g of attapulgite powder were homogenized under high pressure to prepare a slurry, and kept at 70℃±5℃ for later use.

[0060] (4) The slurry was injected into a cylindrical mold with a diameter of 8 mm, cooled to room temperature and solidified, demolded and cut into 2.0 g cylindrical blocks to obtain the tablet sample of Comparative Example 2.

[0061] During the preparation process, after the slurry was injected into the mold and cooled at room temperature (25℃) for 24 hours, although the surface solidified, the interior remained in a paste-like state. Upon demolding, the sample was extremely prone to deformation and adhesion to the mold, making it impossible to obtain a complete, regularly shaped solid. Demolding was barely achieved after lowering the temperature to 4℃, but the sample surface remained sticky. The barely demolded sample was then observed at 25℃ and 50% RH. After 1 hour, the sample softened significantly and deformed easily with light pressure. After 3 hours, an oily exudate appeared on the sample surface (active ingredient migration). After 24 hours, the sample completely softened into a semi-fluid state and could not maintain its cylindrical shape. The sample was too soft to undergo conventional tablet hardness testing; it could be easily crushed with fingers, completely lacking the mechanical strength required for transportation and use. Furthermore, because the sample could not be formed independently, standard release tests were difficult to perform. However, based on its softening and liquid exudation, it can be inferred that the active ingredient will be released rapidly, resulting in a very short duration of effect.

[0062] Therefore, the formulation and process of this comparative example cannot produce solid tablets with practical value, and are especially unsuitable as cockroach attractants that require long-term storage, transportation, and use. The fundamental reason is that the strong moisturizing properties of the high glycerol content (25%) prevent the gel matrix from drying and hardening, while the fatty compounds (15%) have a low melting point (50-70℃) and soften at room temperature, resulting in instability of the entire system.

[0063] Release test Release tests were conducted on the samples of Example 1 and Comparative Example 1. The tests were conducted in a closed room with constant temperature and humidity. The test samples were the formulations described in Examples 1-4 and Comparative Example 1. Three tablets of each of the five samples were prepared for parallel release tests.

[0064] The specific implementation process is as follows: The sample was placed into a 30 mm diameter sample vial, which was then placed in a 500 ml beaker. An appropriate amount of ethyl acetate (analytical grade) was added to the beaker, and the beaker was immediately sealed. At regular intervals, a small amount of ethyl acetate containing the absorbed active ingredient was taken from the beaker and scanned using a UV-Vis spectrophotometer. The results were then analyzed using pre-determined methods. Figure 1 The concentration of the active ingredient is converted from the standard curve shown, and the release rate of the active ingredient is finally obtained.

[0065] Release rate = (Measured active ingredient content / Total active ingredient content per tablet) × 100% The residual rate curves measured for samples from Examples 1-4 and Comparative Example 1 are shown below. Figure 2 As shown in Table 1, the release rates are as follows. Table 1. Comparison of release rates of samples from Examples 1-4 and Comparative Example 1 The release rate of the active ingredient in Comparative Example 1 was significantly faster than that in Example 1: 2.21% was released in 3 days, 65.34% in 30 days, and 100% complete release was achieved in 90 days. This indicates that without the gelatin / SDS micelle encapsulation system, the active ingredient cannot be effectively released, and the duration of effect is greatly shortened.

[0066] The release rate of Example 1 is significantly superior to other formulations, with a residual rate of 3.45% at day 120, demonstrating excellent controlled-release performance. This is presumably due to the highly entangled gelatin molecular chains forming a network, and the abundant hydrogen bond donors effectively restraining the SDS micelles, which are surrounded by hydrophilic groups and encapsulate the active ingredient, thus enhancing their stability.

[0067] Example 2 showed a slightly higher release rate at 120 days than Example 1, but its overall controlled-release performance was superior to Comparative Example 1 and other examples. This is because octenyl succinate starch ester itself has better emulsifying properties for the active ingredient and can form strong non-covalent interactions with the active ingredient, such as hydrogen bonds and hydrophobic interactions, thereby delaying release. However, during the preparation process, in order to achieve a good emulsification effect, the viscosity of this emulsion is usually relatively high. Compared with gelatin emulsions, it is difficult to mix evenly with excipients, which is an important factor affecting the difference in formulation content.

[0068] The release rate of Example 3 was only better than that of Comparative Example 1, and worse than that of other examples. This is because there is no strong non-covalent interaction between polyethylene glycol molecules, making it difficult to stabilize the micelles and thus weakening its controlled release performance.

[0069] The release rate of Example 4 was better than that of Comparative Example 1 and Example 3, but inferior to that of Example 1 and Example 2. This is because β-cyclodextrin is an oligomer. Although its molecular cavity has a large number of hydrophilic groups, which provide a structural advantage for stabilizing micelles, its loading capacity is limited. When the content of the active ingredient is high, an initial burst release phenomenon will occur. Its release rate within 14 days is higher than that of Example 1 and Example 2. If β-cyclodextrin is used to achieve a better controlled release effect, then the compatibility between the molecular size of the active ingredient and the cyclodextrin cavity is also a key consideration.

[0070] The above description discloses only preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. Therefore, equivalent variations made in accordance with the claims of the present invention are still within the scope of the present invention.

Claims

1. A cockroach-attracting slow-release tablet, characterized in that, It is prepared from raw materials containing the following components in weight percentage: Active ingredient 1% - 10%; Surfactant 0.5% - 5%; Fragrance fixative 0.5% - 2%; Skeleton material 30% - 60%; Adhesive 2% - 6%; The rest is water; The active ingredient includes cockroach pheromones and / or fragrance enhancers, and the skeletal material includes at least one of calcium carbonate, mannitol, common starch, dicalcium phosphate, and microcrystalline cellulose. The tablets are prepared by forming a micelle emulsion with the active ingredient, a surfactant, a flavor fixative, and water, then mixing the micelle emulsion with a matrix material, followed by wet granulation, drying, and tableting.

2. The cockroach attractant slow-release tablet according to claim 1, characterized in that: The cockroach pheromone includes at least one of benzyl benzoate, 4-butyloctanol, 1-octen-3-ol acetate, cyclohexyl propionate, verbenaenoyl acetate, and isoborneol acetate; the fragrance enhancer includes at least one of methylcyclopentenolone, 1-hexanol, propylene glycol, 1,3-dihydroxyacetone, 2-amino-3-methylbutyric acid, and methylcyclopentenolone.

3. The cockroach attractant slow-release tablet according to claim 1, characterized in that: The adhesive includes polyvinylpyrrolidone; the fixative is selected from at least one of modified starch, β-cyclodextrin, polyethylene glycol, and gelatin, wherein the modified starch is selected from at least one of carboxymethyl starch, pregelatinized starch, and octenyl succinate starch ester.

4. The cockroach attractant slow-release tablet according to claim 1, characterized in that: The surfactant is selected from at least one of sodium stearate, sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, fatty alcohol polyoxyethylene ether, and decaethylene glycol monododecyl ether.

5. A method for preparing a cockroach-attracting sustained-release tablet according to any one of claims 1-4, characterized in that, Includes the following steps: S1. Mix the fixative, surfactant, active ingredient and water in proportion, and heat and stir until a uniform and stable micelle emulsion is formed; S2. Add the skeleton material to the micelle emulsion and mix evenly, then add the adhesive and continue mixing until a moist soft material is formed; S3. The soft material is granulated into wet granules using a granulator, and then dried to obtain dry granules; S4. Compress the dry granules into tablets to obtain the cockroach-attracting sustained-release tablets.

6. The preparation method according to claim 5, characterized in that: In step S1, the heating temperature is 50-60℃.

7. The preparation method according to claim 5, characterized in that: In step S3, the drying temperature is 40-60℃.

8. The preparation method according to claim 5, characterized in that: In step S3, the particle size of the wet particles is 0.6-0.8 mm.

9. The preparation method according to claim 5, characterized in that: In step S4, the tableting pressure is 40-80 kN.

10. The use of the cockroach attractant slow-release tablet according to any one of claims 1-4 or the cockroach attractant slow-release tablet prepared by the preparation method according to any one of claims 5-9 in the preparation of cockroach trapping devices or cockroach baiting products.

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