Multi-modal flexible neural electrode with flux scalability and site arrangement configurability

Abstract

The application discloses a multi-modal flexible neural electrode with scalable flux and configurable site arrangement, comprising: an electrode interface part; a lead part connected with the electrode interface part; a folding part connected with the lead part, the folding part comprising a foldable connecting part and a plurality of folding units, the plurality of folding units being arranged at intervals along a first direction, and two adjacent folding units being connected through the foldable connecting part, the folding part being configured to make the plurality of folding units stack along a thickness direction by folding the foldable connecting part; and a plurality of implant handle parts, the plurality of implant handle parts being respectively arranged on the plurality of folding units, and each implant handle part being provided with an electrode site. The multi-modal flexible neural electrode with scalable flux and configurable site arrangement has the advantages of large flux, small implant damage, high flexibility, good consistency, strong controllability and the like.

Description

Technical Field

[0001] This invention relates to the field of neural electrode technology, and more specifically, to a multimodal flexible neural electrode with scalable throughput and configurable site arrangement. Background Technology

[0002] Neuroelectrodes are core devices for exploring brain science, diagnosing and treating brain diseases, and realizing brain-computer interfaces. Rigid electrodes are severely mismatched with the mechanical properties of brain tissue, and are prone to continuous damage to tissues or blood vessels during chronic recording, inducing neuronal apoptosis and glial scar proliferation, ultimately leading to the failure of long-term neural recording and modulation.

[0003] Flexible neural electrodes are fabricated on polymer substrates using ultraviolet lithography to create flexible cortical or deep brain electrodes. By leveraging the ultra-thin and low-bending stiffness of the polymer substrate, continuous damage to tissues and blood vessels can be significantly reduced.

[0004] Flexible neural electrodes in related technologies, based on two-dimensional planar photolithography, directly lead to a linear increase in the width of the electrode handle due to the increase in the number of channels. This expansion of physical size significantly increases tissue displacement and vascular damage during electrode implantation, making it difficult to simultaneously achieve "increased signal sampling throughput" and "reduced tissue damage." Furthermore, the flexibility of these electrodes makes it difficult to achieve freely customizable arrangement of recording and stimulation sites on a single flexible electrode, limiting their widespread application. In addition, to achieve three-dimensional spatial coverage, these flexible neural electrodes often rely on the random assembly of flexible microfilaments or the stacking of multiple electrode handles on a PCB. The former results in random and uncontrollable three-dimensional coordinates of the electrode sites in brain tissue, greatly increasing the difficulty of signal decoding; the latter, due to the large size of the back-end interface, limits the overall miniaturization capability of the system, making it difficult to meet the requirements of lightweight and high integration for chronic implantation. Summary of the Invention

[0005] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention proposes a multimodal flexible neural electrode with scalable throughput and configurable site arrangement. This multimodal flexible neural electrode with scalable throughput and configurable site arrangement has the advantages of high throughput, minimal implantation damage, high flexibility, good consistency, and strong controllability.

[0006] To achieve the above objectives, an embodiment of the present invention provides a multimodal flexible neural electrode with scalable throughput and configurable site arrangement. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement includes: an electrode interface portion; a lead portion connected to the electrode interface portion; a folding portion connected to the lead portion, the folding portion including a foldable connecting portion and multiple folding units, the multiple folding units being spaced apart along a first direction, adjacent folding units being connected via the foldable connecting portion, the folding portion being configured such that the multiple folding units are stacked along the thickness direction by folding the foldable connecting portion; and multiple implantation stems, the multiple implantation stems being respectively disposed on the multiple folding units, each implantation stem having an electrode site.

[0007] The multimodal flexible neural electrode according to embodiments of the present invention has advantages such as high throughput, minimal implantation damage, high flexibility, good consistency, and strong controllability.

[0008] In addition, the multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to the above embodiments of the present invention may also have the following additional technical features: According to one embodiment of the present invention, there are multiple foldable connecting portions, and the width of the multiple foldable connecting portions gradually increases along the direction from the end of the foldable portion away from the lead portion to the end of the foldable portion near the lead portion.

[0009] According to one embodiment of the present invention, the plurality of electrode sites are all located on the same side in the thickness direction of the fold.

[0010] According to one embodiment of the present invention, each of the folding units is provided with one or more of the implantation stem portions.

[0011] According to one embodiment of the present invention, the plurality of folding units include a stem unit and a stemless unit, the stem unit and the stemless unit being alternately arranged along the first direction, and each stem unit having one or more implantable stems.

[0012] According to one embodiment of the present invention, a thickness adjustment pad is provided on a plurality of the handleless units.

[0013] According to one embodiment of the present invention, the electrode site includes one or more of the following: recording site, electrical stimulation site, electrical stimulation location site, and photostimulation site.

[0014] According to one embodiment of the present invention, the thickness of the foldable connector is less than that of the folding unit.

[0015] According to one embodiment of the present invention, the flexibility of the foldable connector is greater than that of the folding unit.

[0016] According to one embodiment of the present invention, the foldable connecting part is provided with a foldable slot.

[0017] Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0018] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which: Figure 1 This is a schematic diagram of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to a specific embodiment of the present invention.

[0019] Figure 2 This is a partial structural diagram of the implantation stalk of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to a specific embodiment of the present invention.

[0020] Figure 3 This is a partial structural schematic diagram of the implantation stalk of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0021] Figure 4 This is a partial structural schematic diagram of the implantation stalk of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0022] Figure 5 This is a partial structural schematic diagram of the implantation stalk of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0023] Figure 6 This is a partial structural schematic diagram of the implantation stalk of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0024] Figure 7 This is a schematic diagram of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0025] Figure 8 This is a schematic diagram of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0026] Figure 9This is a schematic diagram of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0027] Figure 10 This is a schematic diagram of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to another specific embodiment of the present invention.

[0028] Figure 11 This is a schematic diagram of the folding configuration of a multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to an embodiment of the present invention.

[0029] Figure reference numerals: 1. Multimodal flexible neural electrode with scalable throughput and configurable site arrangement; 10. Electrode interface; 20. Lead wire; 30. Foldable connection; 31. Foldable unit; 32. Unit with handle; 321. Unit without handle; 322. Thickness adjustment pad; 33. Implant handle; 40. Electrode site; 50. Recording site; 51. Electrical stimulation site; 52. Electrical stimulation location; 53. Detailed Implementation

[0030] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0031] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the invention. Furthermore, features defined with "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more. In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0032] The following description, with reference to the accompanying drawings, describes a multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement according to an embodiment of the present invention.

[0033] like Figures 1-11 As shown, the multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement according to an embodiment of the present invention includes an electrode interface portion 10, a lead portion 20, a folding portion 30, and a plurality of implantation stem portions 40.

[0034] The lead portion 20 is connected to the electrode interface portion 10. The folding portion 30 is connected to the lead portion 20 and includes a foldable connecting portion 31 and multiple folding units 32. The multiple folding units 32 are arranged at intervals along a first direction, and adjacent folding units 32 are connected by the foldable connecting portion 31. The folding portion 30 is configured such that the multiple folding units 32 are stacked along the thickness direction by folding the foldable connecting portion 31. Multiple implantation stems 40 are respectively provided on the multiple folding units 32, and each implantation stem 40 is provided with an electrode site 50.

[0035] Specifically, the first direction can be the length direction of the folded portion 30, and the length direction of the implantation stem 40 can be perpendicular to the first direction. The lead portion 20 is connected to one end of the folded portion 30 along its length.

[0036] like Figure 11 As shown, the foldable connecting portion 31 is suitable for folding 180 degrees, and the folding directions of multiple foldable connecting portions 31 can be the same. For example, suppose multiple folding units 32, from the end away from the lead portion 20 to the end near the lead portion 20, are respectively a first folding unit, a second folding unit, and a third folding unit. After the first folding unit and the second folding unit are folded together, the third folding unit is folded onto the surface of the first folding unit that is away from the second folding unit, and so on. It is important to understand here that... Figure 11 The thickness and gap are only for illustrating the folding method and are not a limitation on the actual size.

[0037] The multimodal flexible neural electrode 1, with scalable throughput and configurable site arrangement, can be fabricated using micro-nano fabrication techniques. Before folding and assembly, it is planar. Multiple folding units 32 are folded sequentially from the end away from the lead portion 20 to the end near the lead portion 20, thereby forming a multilayer electrode structure.

[0038] The width of each electrode stem in the folded and assembled multilayer electrode is determined by the width of the implantation stem 40 of a single folded unit 32, and the thickness is the sum of the thicknesses of the implantation stems 40 of multiple folded units 32. Since the thickness of the implantation stem 40 is much smaller than its width, the thickness of each electrode stem after folding and assembly is also smaller than the width of the implantation stem 40 of a single folded unit 32.

[0039] Furthermore, thanks to the folded assembly characteristics, the site arrangement on any side of the multilayer electrode is highly flexible and controllable. For example, such as Figure 2 As shown, a linear arrangement of recording sites 51 can be achieved; as Figure 3 As shown, a high-density arrangement of recording sites 51 can be achieved; as Figure 4 As shown, clustered arrangement of recording sites 51 can be achieved; as Figure 5 As shown, a mixed arrangement of recording site 51 and electrical stimulation site 52 can be achieved; as Figure 6 As shown, a mixed arrangement of recording site 51, electrical stimulation site 52, and electrical stimulation site 53 can be achieved.

[0040] Furthermore, thanks to the folding assembly characteristics, different structures can be realized, such as single-handle double-sided site distribution structure, single-handle single-sided site distribution structure, multi-handle electrode structure, and three-dimensional electrode array structure.

[0041] For example, the multiple folding units 32 can be divided into multiple odd units and multiple even units, with the multiple odd units and multiple even units alternating.

[0042] like Figure 1 As shown, each folded unit 32 is provided with an implantation stem 40. The single-stem multilayer electrode after folding and assembly has electrode sites 50 distributed on both sides. The electrode sites 50 of odd-numbered units are distributed on one side of the single-stem multilayer electrode, and the electrode sites 50 of even-numbered units are distributed on the other side of the single-stem multilayer electrode.

[0043] like Figure 7 As shown, the single-handle multilayer electrode can also be a single-sided site distribution type. Odd-numbered units of the single-handle multilayer electrode have an implantation handle 40, while even-numbered units do not. Therefore, the electrode sites 50 after folding and assembly are only distributed on one side. Similarly, even-numbered units can have an implantation handle 40, while odd-numbered units do not, and the electrode sites 50 after folding and assembly are also only distributed on one side.

[0044] like Figure 8 and Figure 9 As shown, it can also be constructed as a multi-stem electrode structure. A folding unit 32 is connected to multiple implantation stems 40; the figure shows an embodiment where one folding unit 32 connects two implantation stems 40. Any one of the electrode stems of the multi-stem electrode possesses all the characteristics of the aforementioned single-stem multilayer electrode, and can also achieve both high throughput and low damage. Figure 8 As shown, the site arrangement can be bifacial, or as... Figure 9 As shown, the site arrangement is single-sided, and the site arrangements on the two surfaces are decoupled from each other and can be designed independently. The site arrangement on either side is highly flexible and controllable.

[0045] like Figure 10 As shown, it can also be constructed as a three-dimensional electrode array structure. Odd-numbered units have implant stems, and the number and spacing of implant stems 40 connected to an odd-numbered unit are adjustable. Even-numbered units do not have implant stems 40, but have thickness adjustment pads 33, the thickness of which is adjustable. After assembly, the implant stems 40 connected to the odd-numbered units form each row of the three-dimensional electrode array, separated by the thickness adjustment pads 33 of the even-numbered units, thus realizing a three-dimensional electrode array structure. The number of electrode stems per row, the spacing between electrode stems per row, and the spacing between electrode stem rows are all controllable and customizable.

[0046] The multimodal flexible neural electrode 1 of the present invention, which features scalable throughput and configurable site arrangement, incorporates a folding portion 30. This folding portion 30 includes a foldable connecting portion 31 and multiple folding units 32. The folding portion 30 is configured such that the multiple folding units 32 are stacked along the thickness direction by folding the foldable connecting portion 31. This allows for the assembly of multiple implantation stems 40 by folding the folding portion 30. The width of each electrode stem in the assembled multilayer electrode is determined by the width of the implantation stem 40 of a single folding unit 32, and the thickness is the sum of the thicknesses of the implantation stems 40 of multiple folding units 32. Since the thickness of the implantation stem 40 is much smaller than its width, the thickness of each electrode stem after folding and assembly is also smaller than the width of the implantation stem 40 of a single folding unit 32. Compared to flexible neural electrodes in related technologies, this avoids the increase in electrode stem width due to an increase in the number of electrode channels, which could exacerbate tissue damage during implantation. It also facilitates reducing the width of each electrode stem, improving throughput while controlling the lateral width of the electrode stem, effectively reducing implantation damage and overcoming the limitation of increased electrode width due to throughput expansion in related technologies.

[0047] Furthermore, due to the folding assembly method, it is easy to achieve flexible and controllable arrangement of recording and stimulation sites, which solves the technical bottleneck of single electrode function and limited site arrangement in related technologies. It provides a highly flexible solution for neuroscience research and clinical neuromodulation, and meets the needs of different brain regions and different neural signal processing strategies.

[0048] Furthermore, due to the folding assembly method, it is easy to construct different structures such as single-handle, multi-handle electrode structures or three-dimensional electrodes. Moreover, it is not a direct superposition of multiple independent electrodes, which ensures the consistency of mechanical and electrical properties of each handle. This overcomes the randomness and instability of assembly schemes in related technologies, and constructs a flexible neural electrode with controllable interface and high integration based on a single-unit structure.

[0049] Therefore, the multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement according to the embodiments of the present invention has advantages such as high throughput, minimal implantation damage, high flexibility, good consistency, and strong controllability.

[0050] The following description, with reference to the accompanying drawings, describes a multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement according to a specific embodiment of the present invention.

[0051] In some specific embodiments of the present invention, such as Figures 1-11 As shown, the multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement according to an embodiment of the present invention includes an electrode interface portion 10, a lead portion 20, a folding portion 30, and a plurality of implantation stem portions 40.

[0052] Advantageously, such as Figure 1 , Figures 7-11 As shown, there are multiple foldable connecting portions 31, and the width of the multiple foldable connecting portions 31 gradually increases from the end of the folding portion 30 away from the lead portion 20 to the end of the folding portion 30 near the lead portion 20. This allows the foldable connecting portions 31 to adapt to the gradually increasing thickness as the folding units 32 are stacked during the folding process, making it easier for the folding portion 30 to be folded.

[0053] Specifically, such as Figure 1 , Figures 7-10 As shown, multiple electrode sites 50 are all located on the same side of the thickness direction of the folded portion 30. This facilitates the placement of the electrode sites 50 and the fabrication and manufacturing of the multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement.

[0054] In some embodiments, such as Figure 1 and Figure 8 As shown, each folded unit 32 is provided with one or more implantation stems 40. This facilitates the formation of a bifacial site structure.

[0055] In some embodiments, such as Figure 7 , Figure 9 , Figure 10As shown, the plurality of folding units 32 include a stem-containing unit 321 and a stemless unit 322, which are alternately arranged along the first direction. Each stem-containing unit 321 is provided with one or more implantation stems 40. This facilitates the formation of a single-sided site structure.

[0056] In some embodiments, such as Figure 10 As shown, multiple handleless units 322 are provided with thickness adjustment pads 33. This facilitates the formation of a three-dimensional electrode array structure.

[0057] Optionally, such as Figures 2-6 As shown, the electrode site 50 includes one or more of the following: a recording site 51, an electrical stimulation site 52, an electrical stimulation site 53, and a photostimulation site. Specifically, the photostimulation site can be a light-emitting diode and is soldered to the implant stem 40. This facilitates meeting different recording and stimulation needs.

[0058] For example, in some implementations, it can be constructed as a single-handle electrode: using standard micro / nano fabrication processes, a planar electrode array is prepared, the basic structure of which is as follows: Figure 1 As shown. Starting with the folding unit 32 furthest from the lead portion 20, the folding process is repeated to form a single-handle multilayer electrode structure from multiple folding units 32. The width of the folded and assembled single-handle multilayer electrode is determined by the width of the implantation handle 40 of a single folding unit 32, and the thickness is the sum of the thicknesses of the implantation handles of multiple folding units 32. Since the thickness of flexible electrodes manufactured by standard micro-nano fabrication processes is much smaller than their width, the thickness of the folded and assembled single-handle multilayer electrode is also smaller than the width of the implantation handle 40 of a single folding unit 32. Therefore, this scheme effectively reduces implantation damage to high-throughput electrodes. In addition, the folding and assembly characteristics result in electrode sites 50 distributed on both sides of the assembled single-handle multilayer electrode. More specifically, the sites of odd-numbered units are distributed on one side of the single-handle multilayer electrode, and the sites of even-numbered units are distributed on the other side. The site arrangement on both surfaces of the single-handle multilayer electrode is decoupled, and the site layout, type, and number on both surfaces are designed independently to achieve symmetrical or asymmetrical double-sided arrangements.

[0059] In some embodiments, such as Figure 7 As shown, a single-handle multilayer electrode can also be a single-sided site distribution type. Odd-numbered units of a single-handle multilayer electrode have an implantation handle, while even-numbered units do not. Therefore, the electrode sites after folding and assembly are distributed only on one side. Similarly, if odd-numbered units do not have an implantation handle, while even-numbered units do, the electrode sites after folding and assembly are also distributed only on one side.

[0060] In some embodiments, such as Figure 8 and Figure 9As shown, it can also be constructed as a multi-stem electrode: a planar electrode array is fabricated using standard micro / nano fabrication processes. The difference from a single-stem multilayer electrode is that a multi-stem electrode has multiple implantable stems 40 connected within a single folded unit 32. Figure 8 and Figure 9 An embodiment is shown where a folding unit 32 connects two implantation stems 40. Therefore, any one stem of the multi-stem electrode possesses all the characteristics of the aforementioned single-stem multilayer electrode, including: the ability to balance high throughput and low invasiveness, and the site arrangement can be as follows: Figure 8 The double-sided or as shown Figure 9 The single-sided arrangement shown has decoupled point arrangements on both surfaces, allowing for independent design. The point arrangement on any side is highly flexible and controllable.

[0061] In some embodiments, such as Figure 10 As shown, it can also be constructed as a three-dimensional electrode array: a planar electrode array is fabricated using standard micro-nano fabrication processes. The difference from single-stem and multi-stem electrodes is that only odd-numbered units have implanted stems, and the number of implanted stems and the spacing between them in each odd-numbered unit are customizable; even-numbered units do not have implanted stems but have thickness adjustment pads 33, the thickness of which is adjustable in each even-numbered unit. After assembly, the implanted stems 40 in the odd-numbered units constitute each row of the three-dimensional electrode array and are separated by the thickness adjustment pads 33 in the even-numbered units. Therefore, the number of electrode stems per row, the spacing between electrode stems per row, and the spacing between electrode stem rows in this scheme are all controllable and customizable.

[0062] By customizing the number of implant stems, spacing, and pad thickness of the folded units, parameters such as the number of rows, columns, and column spacing of the three-dimensional array can be precisely controlled, thereby specifically covering specific brain regions and significantly improving signal spatial resolution and modulation targeting.

[0063] Alternatively, the foldable connector 31 can be folded in a variety of ways.

[0064] In some embodiments, the thickness of the foldable connector 31 is less than that of the folding unit 32. This facilitates the folding of the foldable connector 31 and improves the structural strength of the folding unit 32.

[0065] In some embodiments, the flexibility of the foldable connector 31 is greater than that of the folding unit 32. This also facilitates the folding of the foldable connector 31.

[0066] In some embodiments, the foldable connector 31 is provided with a folding slot. This facilitates folding of the foldable connector 31 by reducing its structural strength and rigidity.

[0067] Specifically, the multimodal flexible neural electrode 1, which has scalable throughput and configurable site arrangement, can be made of poly(p-dichlorotoluene) or polyimide to ensure structural strength and reliability while facilitating manufacturing.

[0068] The thickness adjustment shim 33 can be made of polydimethylsiloxane, polyimide, epoxy resin, metal or plastic to ensure structural strength and reliability while facilitating processing and manufacturing.

[0069] Other configurations and operations of the multimodal flexible neural electrode 1 with scalable throughput and configurable site arrangement according to embodiments of the present invention are known to those skilled in the art and will not be described in detail here.

[0070] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0071] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A multimodal flexible neural electrode with scalable throughput and configurable site arrangement, characterized in that, include: Electrode interface section; A lead portion, wherein the lead portion is connected to the electrode interface portion; The folding portion is connected to the lead portion. The folding portion includes a foldable connecting portion and a plurality of folding units. The plurality of folding units are arranged at intervals along a first direction. Adjacent folding units are connected through the foldable connecting portion. The folding portion is configured to stack the plurality of folding units along the thickness direction by folding the foldable connecting portion. Multiple implantable stems are disposed on multiple folding units, and each implantable stem is provided with an electrode site.

2. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, The foldable connector is a plurality of such connectors, and the width of the plurality of such foldable connectors gradually increases along the direction from the end of the foldable connector away from the lead portion to the end of the foldable connector closer to the lead portion.

3. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, All of the electrode sites are located on the same side of the thickness direction of the fold.

4. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, Each of the folded units is provided with one or more of the implant stems.

5. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, The plurality of folding units include a stem unit and a stemless unit, the stem unit and the stemless unit being alternately arranged along the first direction, and each stem unit having one or more implantable stems.

6. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 5, characterized in that, Each of the aforementioned handleless units is provided with a thickness adjustment pad.

7. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, The electrode sites include one or more of the following: recording sites, electrical stimulation sites, electrical stimulation sites, and photostimulation sites.

8. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, The thickness of the foldable connector is less than that of the folding unit.

9. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, The flexibility of the foldable connector is greater than that of the folding unit.

10. The multimodal flexible neural electrode with scalable throughput and configurable site arrangement according to claim 1, characterized in that, The foldable connector is provided with an easy-folding slot.

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