Cerium oxide antibacterial material, preparation method thereof and application thereof in daily chemical products

Abstract

The application discloses a cerium oxide antibacterial material and a preparation method and application thereof in daily chemical products, and belongs to the technical field of cerium oxide antibacterial materials; the preparation steps of the cerium oxide antibacterial material are as follows: firstly, the surface of nano cerium oxide is modified with glutamic acid, and then the cerium oxide antibacterial material is prepared by a thin film-ultrasonic dispersion method through the combination of the nano cerium oxide and a lipid solution; the lipid solution comprises lecithin, cholesterol and paclitaxel; the cerium oxide antibacterial material prepared by the application has good biocompatibility, good antibacterial property, good stability and low skin irritation; the cerium oxide antibacterial material prepared by the application is suitable for daily cleaning, oral care, clothes washing and skin care.

Description

Technical Field

[0001] This invention relates to the field of cerium oxide antibacterial materials technology, specifically to a cerium oxide antibacterial material, its preparation method, and its application in daily chemical products. Background Technology

[0002] Currently, most antibacterial shampooing, cleaning, and care products on the market rely on organic antibacterial agents, metal ion antibacterial agents, or plant extracts as their core antibacterial ingredients. However, these traditional ingredients have significant limitations in practical applications: long-term use of organic antibacterial agents can easily induce drug resistance in microorganisms, and they can irritate the skin, and they are easily decomposed and ineffective under high temperatures; while metal antibacterial agents such as silver ions have good antibacterial effects, they are expensive, pose potential heavy metal safety hazards, and are easily deactivated in alkaline washing systems; plant extracts generally suffer from poor stability, a narrow antibacterial spectrum, and are prone to oxidation and discoloration.

[0003] Nano-cerium oxide, as a novel functional material with excellent performance, possesses unique nanoenzyme activity, reversible redox cycle capability of Ce3+ / Ce4+, and electrostatic adsorption properties. It can achieve broad-spectrum, long-lasting, and drug-free antibacterial effects, exhibiting strong inhibitory effects against common pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, Candida albicans, and molds, while also demonstrating excellent biocompatibility and safety. Despite its promising prospects, the preparation and application of nano-cerium oxide powder still face significant challenges. Existing technologies show that nano-cerium oxide particles have high surface energy, making them prone to aggregation. This results in difficulty in achieving uniform dispersion in various daily chemical systems such as soap bases, creams, liquids, and emulsions, severely limiting its antibacterial properties. Although introducing traditional dispersants can prevent aggregation to some extent, it often fails to completely eliminate the grainy feel, and residual micro-agglomerates can still cause frictional irritation to the skin. Currently, the industry lacks a unified nano-cerium oxide antibacterial technology applicable to multiple categories of daily chemical products, failing to simultaneously achieve excellent dispersion stability and a gentle skin feel.

[0004] Therefore, there is an urgent need to develop a cerium oxide antibacterial material and its preparation method to solve the above problems. Summary of the Invention

[0005] The purpose of this invention is to provide a cerium oxide antibacterial material, its preparation method, and its application in daily chemical products, so as to solve the technical problems mentioned in the background art.

[0006] The technical solution to achieve the objective of this invention is: In a first aspect, the present invention provides a method for preparing a cerium oxide antibacterial material, comprising the following steps: (1) Disperse 0.8-0.9 parts by mass of nano-cerium oxide in 100 parts by mass of deionized water, cool to 0-4℃, add hydrochloric acid to adjust pH < 3, stir for 50-70 min, then add 30-40 parts by mass of glutamic acid solution, continue stirring for 110-130 min, let stand to separate into layers, remove the supernatant, wash the obtained precipitate with double-distilled water 5-7 times, add double-distilled water and sonicate for at least 20 min to obtain glutamic acid modified nano-cerium oxide dispersion; under acidic conditions, the carboxyl group in the glutamic acid molecule coordinates with the cerium on the surface of nano-cerium oxide to form a stable coating layer; (2) 4.2-4.6 parts by weight of lipid solution were rotary evaporated at 50-60℃ to form a uniform film. The film was then evaporated under reduced pressure at 50-60℃ for 30 min. Then, 2.15-3.08 parts by weight of glutamic acid modified nano-cerium oxide dispersion and 2.5-3 parts by weight of glucose solution were added. The film was shaken by hand for at least 30 min and then ultrasonically treated for at least 20 min. The well dispersed glutamic acid modified nano-cerium oxide was uniformly embedded in the liposomes to obtain cerium oxide antibacterial material.

[0007] Furthermore, the concentration of the glutamic acid solution is 4.5~5 g / L.

[0008] Further, the preparation steps of the lipid solution are as follows: 0.15~0.20 parts by weight of lecithin, 0.035~0.045 parts by weight of cholesterol, and 0.01 parts by weight of paclitaxel are dissolved in 4 parts by weight of anhydrous ethanol to obtain a lipid solution; paclitaxel has multiple skin care effects such as antibacterial, anti-aging, and antioxidant properties. During the preparation of liposomes, it can be embedded in the hydrophobic region of the phospholipid bilayer, and together with phospholipids and cholesterol, it forms a stable lipid membrane structure, thereby enhancing the structural stability of the lipid membrane.

[0009] Furthermore, the concentration of the glutamic acid-modified cerium oxide nano-dispersion is 13-14 g / L.

[0010] Furthermore, the nano-cerium oxide particles have a diameter of 50~200nm, a purity of ≥99.9%, and a heavy metal content of ≤1ppm.

[0011] In a second aspect, a cerium oxide antibacterial material is prepared by the method for preparing the cerium oxide antibacterial material described in the first aspect.

[0012] Thirdly, the application of a cerium oxide antibacterial material prepared by the method described in the first aspect in daily chemical products, including soap, toothpaste, laundry detergent, and cosmetics.

[0013] Furthermore, the amount of cerium oxide antibacterial material added to the soap is 0.5~2wt%.

[0014] Furthermore, the amount of cerium oxide antibacterial material added to the toothpaste is 0.2-1%.

[0015] Furthermore, the amount of cerium oxide antibacterial material added to the laundry detergent is 0.1-0.8%; the amount of cerium oxide antibacterial material added to the cosmetic is 0.1-1.5%.

[0016] By adopting the above technical solution, the present invention has the following beneficial effects: (1) In the preparation of the cerium oxide antibacterial material of the present invention, glutamic acid is first modified on the surface of nano-cerium oxide to obtain glutamic acid modified nano-cerium oxide dispersion, and then glutamic acid modified nano-cerium oxide dispersion and lipid solution are prepared by thin film-ultrasound dispersion method to obtain liposome cerium oxide antibacterial material; the prepared cerium oxide antibacterial material can be stably dispersed in different daily chemical systems such as soap base, paste, liquid, and emulsion without the addition of dispersant, and has a good skin feel.

[0017] (2) In this invention, glutamic acid is modified on the surface of nano-cerium oxide. First, glutamic acid is an amino acid that is widely used in the skin care field. It has excellent moisturizing properties and can absorb moisture from the air to keep the skin hydrated. It also has the ability to resist oxidation and repair damaged skin tissue. Second, under acidic conditions, the carboxyl group in the glutamic acid molecule coordinates with the cerium on the surface of nano-cerium oxide to form a stable coating layer, thereby effectively reducing the surface energy of nano-cerium oxide and preventing the nano-cerium oxide from agglomerating. In the subsequent thin film-ultrasonic dispersion method, the well dispersed glutamic acid-modified nano-cerium oxide can be uniformly embedded in liposomes to form a stable and uniformly encapsulated liposome cerium oxide antibacterial material.

[0018] (3) In this invention, a glutamic acid-modified nano-cerium oxide dispersion and a lipid solution are dispersed by a thin film-ultrasonic method to form a structurally stable and uniformly encapsulated liposomal cerium oxide antibacterial material. The liposomes are composed of a phospholipid bilayer. The outer hydrophilic head is compatible with the aqueous environment, while the inner hydrophobic tail can coexist with oily components. At the same time, the phospholipid bilayer itself is flexible and can adapt to matrices with different polarities and rheological properties. When liposomal cerium oxide is added to soap bases, creams, liquids and emulsions, the liposome vesicles can exist stably through surface charge and steric hindrance, preventing the cerium oxide inside from being directly exposed to the complex formulation environment and causing aggregation. Stable dispersion can be achieved without the addition of dispersants, and the skin feel is good. At the same time, the soft liposome shell physically isolates the nano-cerium oxide particles from the skin, significantly reducing the friction irritation caused by the particles, thus giving the product excellent skin feel and gentleness.

[0019] (4) The lipid solution of the present invention includes lecithin, cholesterol and paclitaxel. Paclitaxel has multiple skin care effects such as antibacterial, anti-aging and antioxidant. During the preparation of liposomes, it can be embedded in the hydrophobic region of the phospholipid bilayer and together with phospholipids and cholesterol to form a stable lipid membrane structure. Embedding in the lipid membrane enhances the structural stability. It forms a dual antibacterial synergy with cerium oxide and complements glutamic acid for moisturizing and repair. Detailed Implementation

[0020] To better understand the above technical solution, the following will provide a detailed explanation of the technical solution in conjunction with specific implementation methods.

[0021] Therefore, the following detailed description of the embodiments is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0022] The following embodiments are only used to illustrate the technical solutions of the present invention more clearly, and should not be used to limit the scope of protection of the present invention.

[0023] The average particle size of the nano-cerium oxide is 100 nm, and the purity is ≥99.9%.

[0024] Example 1 A method for preparing a cerium oxide antibacterial material includes the following steps: (1) Disperse 0.8 parts by mass of nano-cerium oxide in 100 parts by mass of deionized water, cool to 0℃, add hydrochloric acid to adjust pH=2, stir for 50 min, then add 30 parts by mass of 5 g / L glutamic acid solution, continue stirring for 110 min, let stand to separate into layers, remove the supernatant, wash the obtained precipitate 5 times with double distilled water, add double distilled water and sonicate for 20 min to obtain 13 g / L glutamic acid modified nano-cerium oxide dispersion; (2) Dissolve 0.15 parts by weight of lecithin, 0.035 parts by weight of cholesterol and 0.01 parts by weight of paclitaxel in 4 parts by weight of anhydrous ethanol to obtain a lipid solution; (3) The lipid solution from step (2) was rotary evaporated at 50°C to form a uniform film. The film was then evaporated under reduced pressure at 50°C for 30 min. Then, 2.15 parts by mass of glutamic acid-modified nano-cerium oxide dispersion and 2.5 parts by mass of 5% glucose solution were added. The film was shaken by hand for 30 min and then ultrasonically treated for 20 min to obtain cerium oxide antibacterial material.

[0025] Example 2 A method for preparing a cerium oxide antibacterial material includes the following steps: (1) Disperse 0.875 parts by mass of nano-cerium oxide in 100 parts by mass of deionized water, cool to 2°C, add hydrochloric acid to adjust pH=2.8, stir for 60 min, then add 40 parts by mass of 4.5 g / L glutamic acid solution, continue stirring for 120 min, let stand to separate into layers, remove the supernatant, wash the obtained precipitate with double distilled water 6 times, add double distilled water and sonicate for 20 min to obtain 13.7 g / L glutamic acid modified nano-cerium oxide dispersion; (2) Dissolve 0.187 parts by weight of lecithin, 0.039 parts by weight of cholesterol and 0.01 parts by weight of paclitaxel in 4 parts by weight of anhydrous ethanol to obtain a lipid solution; (3) The lipid solution from step (2) was rotary evaporated at 55°C to form a uniform film. The film was then evaporated under reduced pressure at 55°C for 30 min. Then, 2.15 parts by mass of glutamic acid-modified nano-cerium oxide dispersion and 2.85 parts by mass of 5% glucose solution were added. The film was shaken by hand for 30 min and then ultrasonically treated for 20 min to obtain cerium oxide antibacterial material.

[0026] Example 3 A method for preparing a cerium oxide antibacterial material includes the following steps: (1) Disperse 0.9 parts by mass of nano-cerium oxide in 100 parts by mass of deionized water, cool to 4°C, add hydrochloric acid to adjust pH=3, stir for 70 min, then add 40 parts by mass of 4.5 g / L glutamic acid solution, continue stirring for 130 min, let stand to separate into layers, remove the supernatant, wash the obtained precipitate with double distilled water 7 times, add double distilled water and sonicate for 20 min to obtain 14 g / L glutamic acid modified nano-cerium oxide dispersion; (2) Dissolve 0.20 parts by weight of lecithin, 0.045 parts by weight of cholesterol and 0.01 parts by weight of paclitaxel in 4 parts by weight of anhydrous ethanol to obtain a lipid solution; (3) The lipid solution from step (2) was rotary evaporated at 60°C to form a uniform film. The film was then evaporated under reduced pressure at 60°C for 30 min. Then, 3.08 parts by mass of glutamic acid-modified nano-cerium oxide dispersion and 3 parts by mass of 5% glucose solution were added. The film was shaken by hand for 30 min and then ultrasonically treated for 20 min to obtain cerium oxide antibacterial material.

[0027] Comparative Example 1 A method for preparing a cerium oxide antibacterial material includes the following steps: (1) Dissolve 0.187 parts by weight of lecithin, 0.039 parts by weight of cholesterol and 0.01 parts by weight of paclitaxel in 4 parts by weight of anhydrous ethanol to obtain a lipid solution; (2) The lipid solution from step (1) was rotary evaporated at 55°C to form a uniform film. The film was then evaporated under reduced pressure at 55°C for 30 min. Then, 2.15 parts by weight of 13.7 g / L nano cerium oxide dispersion and 2.85 parts by weight of 5% glucose solution were added. The film was shaken by hand for 30 min and then ultrasonically treated for 20 min to obtain cerium oxide antibacterial material.

[0028] Application Example 1 Antibacterial soap formula: 31 parts sodium laurylate, 31 parts sodium myristate, 31 parts sodium cocoate, 1.5 parts cerium oxide antibacterial material from Example 1, 3 parts glycerin (moisturizer), sodium citrate to adjust pH to 8, 0.3 parts rose fragrance, and the remainder is deionized water.

[0029] Application Example 2 Antibacterial soap formula: 31 parts sodium laurylate, 31 parts sodium myristate, 31 parts sodium cocoate, 1.5 parts cerium oxide antibacterial material (Example 2), 3 parts glycerin (moisturizer), sodium citrate to adjust pH to 8, 0.3 parts lavender fragrance, and the remainder is deionized water.

[0030] Application Example 3 Antibacterial soap formula: 31 parts sodium laurylate, 31 parts sodium myristate, 31 parts sodium cocoate, 1.5 parts cerium oxide antibacterial material (Example 3), 3 parts glycerin (moisturizer), sodium citrate to adjust pH to 8, 0.3 parts lavender fragrance, and the remainder is deionized water.

[0031] Application Example 4 Antibacterial soap formula: 31 parts sodium laurylate, 31 parts sodium myristate, 31 parts sodium cocoate, 1.5 parts cerium oxide, 3 parts glycerin (moisturizer), sodium citrate to adjust pH to 8, 0.3 parts lavender fragrance, 0.5 parts sorbitol (dispersant), and the remainder is deionized water.

[0032] Application Example 5 Antibacterial toothpaste formula: 40 parts silica, 25 parts 70% sorbitol solution, 5 parts glycerin, 0.5 parts sodium carboxymethyl cellulose, 0.5 parts xanthan gum, 2 parts sodium lauroyl sarcosinate, 1 part cerium oxide antibacterial material (Example 2), 0.1 parts dipotassium glycyrrhizate, 0.1 parts allantoin, 0.2 parts sodium saccharin, 0.03 parts sucralose, 0.4 parts sodium benzoate, 0.3 parts sodium pyrophosphate, 0.7 parts peppermint flavor, and the remainder is water.

[0033] Application Example 6 Antibacterial toothpaste formula: 40 parts silica, 25 parts 70% sorbitol solution, 5 parts glycerin, 0.5 parts sodium carboxymethyl cellulose, 0.5 parts xanthan gum, 2 parts sodium lauroyl sarcosinate, 1 part cerium oxide, 0.1 parts dipotassium glycyrrhizate, 0.1 parts allantoin, 0.2 parts sodium saccharin, 0.03 parts sucralose, 0.4 parts sodium benzoate, 0.3 parts sodium pyrophosphate, 0.7 parts peppermint flavor, balance water.

[0034] Application Example 7 Antibacterial cosmetic formula: Carbomer U20 0.6 parts, Glycerin 3 parts, 1,3-Butanediol 2 parts, L-ascorbic acid 0.35 parts, Natural vitamin E 0.55 parts, Cerium oxide antibacterial material from Example 2 1.5 parts, Triethanolamine 0.6 parts, Squalane 0.7 parts, Isooctyl palmitate 5 parts, Stearyl alcohol 4 parts, Phenoxyethanol 0.7 parts, Lavender essential oil 0.02 parts, Balance is water.

[0035] Application Example 8 Antibacterial cosmetic formula: 0.6 parts Carbomer U20, 3 parts Glycerin, 2 parts 1,3-Butanediol, 0.35 parts L-ascorbic acid Vitamin C, 0.55 parts Natural Vitamin E, 1.5 parts Glutamic acid-modified nano-cerium oxide prepared in Example 2, 0.6 parts Triethanolamine, 0.7 parts Squalane, 5 parts Isooctyl Palmitate, 4 parts Stearyl Alcohol, 0.7 parts Phenoxyethanol, 0.02 parts Lavender Essential Oil, and the balance being water.

[0036] Application Example 9 Antibacterial cosmetic formula: Carbomer U20 0.6 parts, Glycerin 3 parts, 1,3-Butanediol 2 parts, L-ascorbic acid 0.35 parts, Natural vitamin E 0.55 parts, Comparative 1 Cerium oxide antibacterial material 1.5 parts, Triethanolamine 0.6 parts, Squalane 0.7 parts, Isooctyl palmitate 5 parts, Stearyl alcohol 4 parts, Phenoxyethanol 0.7 parts, Lavender essential oil 0.02 parts, Balance is water.

[0037] Application Example 10 Antibacterial cosmetic formula: Carbomer U20 0.6 parts, Glycerin 3 parts, 1,3-Butanediol 2 parts, L-ascorbic acid 0.35 parts, Natural vitamin E 0.55 parts, Nano cerium oxide 1.5 parts, Triethanolamine 0.6 parts, Squalane 0.7 parts, Isooctyl palmitate 5 parts, Stearyl alcohol 4 parts, Phenoxyethanol 0.7 parts, Lavender essential oil 0.02 parts, Sorbitol dispersant 0.5 parts, Balance is water.

[0038] Example of effect Antibacterial soap test: Skin irritation test was conducted on the antibacterial soaps prepared according to Examples 1 to 4 respectively. Specifically, when the concentration of the soap solution used in the experiment was 5 wt% and the amount used was 0.3 mL, the skin reaction grade, i.e., the relative irritation value grade, was determined by HETVAM test: strong irritation > 2.0, irritation 1.2~2.0, moderate irritation 0.8~1.2, and mild irritation 0~0.8. The smoothness of the surface of the antibacterial soaps prepared according to Examples 1 to 4 was observed by the naked eye.

[0039] Table 1 below shows the performance test results of the antibacterial soaps used in Examples 1-4: Table 1

[0040] Table 1 shows that the antibacterial soaps in Application Examples 1-3, which contain cerium oxide antibacterial materials from Examples 1-3, have smooth surfaces and better skin feel. The antibacterial soap in Application Example 4 contains nano-cerium oxide and the dispersant sorbitol. A small number of agglomerated particles still exist in the soap, resulting in a slightly rough surface. When used, the skin experiences slight irritation due to the friction caused by the particles.

[0041] Antibacterial toothpaste test: Take a small amount of the antibacterial toothpaste from application examples 5-6 and rub it on your fingertips to observe whether there is a noticeable grainy feeling.

[0042] Table 2 below shows the performance test results of the antibacterial toothpaste used in Examples 5 and 6: Table 2

[0043] Table 2 shows that the antibacterial toothpaste in Application Example 5, which contains the cerium oxide antibacterial material from Example 2, has no obvious grainy feel when rubbed, while the antibacterial toothpaste in Application Example 6, which contains nano-cerium oxide, has an obvious grainy feel when rubbed.

[0044] Dispersion stability test of antibacterial cosmetics: The antibacterial cosmetics in Application Examples 7-9 were placed at room temperature and left to stand for 30 days to observe whether precipitation occurred.

[0045] The basic characteristics of the antibacterial cosmetics in Examples 7-9 were initially judged by touch: rough skin feel 1-5, refreshing skin feel 6-10, and oily skin feel 1-5.

[0046] Weigh 2g of each of the antibacterial cosmetics used in Application Examples 7-10, and place them in an environment at 20℃ and 43% relative humidity for 24 hours. Weigh each antibacterial cosmetic after 24 hours. A higher moisturizing rate indicates less water loss, meaning a better moisturizing effect. The moisturizing rate is calculated using the following formula: Moisturizing rate = m1 / m0 × 100%, where m0 is the initial mass (g) and m1 is the mass after 24 hours (g).

[0047] Table 2 below shows the performance test results of the antibacterial cosmetics used in Examples 7-10: Table 3

[0048] Table 3 shows that the antibacterial cosmetic in Application Example 7, which added the cerium oxide antibacterial material from Example 2, exhibited better dispersion stability, a better skin feel, and better moisturizing performance. Application Example 8, which added glutamic acid-modified nano-cerium oxide instead of the cerium oxide antibacterial material prepared in Example 2, showed poor dispersion stability, precipitation after 30 days of standing, a rough skin feel, and lower moisturizing performance than Application Example 7. Application Example 9, which added the cerium oxide antibacterial material from Comparative Example 1, had a rougher skin feel than Application Example 7, but better dispersion stability, possibly due to uneven dispersion of cerium oxide in the liposomes, and lower moisturizing performance than Application Example 7. Application Example 10, which added nano-cerium oxide and the dispersant sorbitol, showed poor dispersion stability, precipitation after 30 days of standing, a rough skin feel, and lower moisturizing performance than Application Example 7.

[0049] In summary, the preparation of the cerium oxide antibacterial material of the present invention involves first modifying the surface of nano-cerium oxide with glutamic acid, and then preparing liposome cerium oxide antibacterial material by thin-film-ultrasonic dispersion with a lipid solution; the lipid solution includes lecithin, cholesterol, and paclitaxel; the prepared cerium oxide antibacterial material can be stably dispersed in different daily chemical systems such as soap base, cream, liquid, and emulsion without the addition of dispersants, and has a good skin feel and good moisturizing performance.

[0050] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above descriptions are merely specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing a cerium oxide antibacterial material, characterized in that, The steps are as follows: (1) Disperse 0.8-0.9 parts by mass of nano-cerium oxide in 100 parts by mass of deionized water, cool to 0-4℃, add hydrochloric acid to adjust pH < 3, stir for 50-70 min, then add 30-40 parts by mass of glutamic acid solution, continue stirring for 110-130 min, let stand for layering, remove supernatant, wash the obtained precipitate with double distilled water 5-7 times, add double distilled water and sonicate for at least 20 min to obtain glutamic acid modified nano-cerium oxide dispersion; (2) 4.2-4.6 parts by weight of lipid solution were rotary evaporated at 50-60°C to form a uniform film. The film was then evaporated under reduced pressure at 50-60°C for 30 min. Then, 2.15-3.08 parts by weight of glutamic acid modified nano-cerium oxide dispersion and 2.5-3 parts by weight of glucose solution were added. The film was shaken by hand for at least 30 min and then ultrasonically treated for at least 20 min to obtain cerium oxide antibacterial material.

2. The method for preparing the cerium oxide antibacterial material according to claim 1, characterized in that, The concentration of the glutamic acid solution is 4.5~5 g / L.

3. The method for preparing the cerium oxide antibacterial material according to claim 1, characterized in that, The lipid solution is prepared by dissolving 0.15-0.20 parts by weight of lecithin, 0.035-0.045 parts by weight of cholesterol, and 0.01 parts by weight of paclitaxel in 4 parts by weight of anhydrous ethanol to obtain the lipid solution.

4. The method for preparing the cerium oxide antibacterial material according to claim 1, characterized in that, The concentration of the glutamic acid-modified cerium oxide nano-dispersion is 13-14 g / L.

5. The method for preparing the cerium oxide antibacterial material according to claim 1, characterized in that, The nano-cerium oxide particles have a diameter of 50~200nm, a purity of ≥99.9%, and a heavy metal content of ≤1ppm.

6. A cerium oxide antibacterial material, characterized in that, The cerium oxide antibacterial material is prepared by the method for preparing cerium oxide antibacterial material according to any one of claims 1 to 5.

7. The application of a cerium oxide antibacterial material prepared by the method described in any one of claims 1 to 5 in daily chemical products, characterized in that, The daily chemical products include soap, toothpaste, laundry detergent, and cosmetics.

8. The application of the cerium oxide antibacterial material according to claim 7 in daily chemical products, characterized in that, The amount of cerium oxide antibacterial material added to the soap is 0.5~2wt%.

9. The application of the cerium oxide antibacterial material according to claim 7 in daily chemical products, characterized in that, The amount of cerium oxide antibacterial material added to the toothpaste is 0.2-1%.

10. The application of the cerium oxide antibacterial material according to claim 7 in daily chemical products, characterized in that, The amount of cerium oxide antibacterial material added to the laundry detergent is 0.1-0.8%; the amount of cerium oxide antibacterial material added to the cosmetic is 0.1-1.5%.

Images