A warming composition comprising a fat-soluble vitamin C and a method of preparation and use thereof

Abstract

The present application provides a warming composition containing fat-soluble vitamin C, comprising polyol, a warming adjuvant, a thickening agent and a solvent; the warming adjuvant comprises a first warming component, and the first warming component is fat-soluble vitamin C. The warming composition comprises 10-40 parts of polyol and 0.02-2 parts of the first warming component. The warming composition brings a warming use effect to the skin of a user while not causing irritation.

Description

Technical Field

[0001] This invention relates to the field of temperature-sensitive composition technology, and more specifically to a temperature-sensitive composition containing fat-soluble vitamin C, its preparation method, and its uses. Background Technology

[0002] Warming sensation (or heat sensation) refers to the comfortable and noticeable warming effect that a user can subjectively feel after applying cosmetics to the skin. This warming sensation is commonly achieved by adding a warming agent. For example, patent CN119745741A discloses vanillyl butyl ether and clove bud oil as warming agents. Vanillyl butyl ether is the primary agent, providing a strong warming sensation. However, because it acts on the capsaicin receptor (TRPV1), it easily causes irritation and is not suitable for sensitive skin. Patent CN109966219A discloses achieving a warming sensation through capsaicin or gingerol, which also easily causes skin irritation.

[0003] Therefore, providing a temperature-sensitive composition with low irritation is an important research direction. Summary of the Invention

[0004] One objective of this application is to solve at least one of the problems mentioned in the background above and to provide corresponding beneficial effects.

[0005] Another objective of this application is to provide a temperature-sensitive composition containing fat-soluble vitamin C, a method for its preparation, and uses of fat-soluble vitamin C, thereby expanding the applications of fat-soluble vitamin C.

[0006] The embodiments of this application mainly achieve the above objectives through the following technical solutions.

[0007] In one aspect, the present invention provides a temperature-sensitive composition comprising fat-soluble vitamin C, including a polyol, a temperature-sensitive aid, a thickener, and a solvent; the temperature-sensitive aid includes a first temperature-sensitive component, the first temperature-sensitive component being fat-soluble vitamin C; the temperature-sensitive composition comprises:

[0008] 10-40 parts of polyols, and

[0009] 0.02~2 parts of the first temperature-sensing component.

[0010] In some technical solutions, the polyol is one or both of glycerol and butylene glycol.

[0011] In some technical solutions, the temperature-sensing additive further includes a second temperature-sensing component, which is tocopherol and / or a tocopherol derivative. Further, the temperature-sensing composition includes:

[0012] 10-40 parts of polyols,

[0013] 0.2~2 parts of the first temperature-sensing component, and

[0014] 0.05 to 5 parts of the second temperature-sensitive component.

[0015] In a second aspect, the present invention also provides a method for preparing a temperature-sensitive composition comprising fat-soluble vitamin C, comprising the following steps:

[0016] Disperse the solvent and thickener evenly in the main reaction vessel, heat to the first temperature and stir homogenously until uniform;

[0017] Add the polyol to the main reaction vessel, stir well, and cool to the second temperature.

[0018] The temperature-sensitive additive was added to the main reaction vessel, homogenized and stirred until uniform, and then cooled to the third temperature to obtain the composition.

[0019] In a third aspect, the present invention also provides the application of fat-soluble vitamin C as a temperature-sensitive adjuvant in the preparation of a topical skin agent, wherein the topical skin agent includes a polyol.

[0020] In a fourth aspect, the present invention also provides the application of tocopherol and its derivatives as temperature-sensitive adjuvants in the preparation of topical skin preparations, wherein the topical skin preparations include polyols and fat-soluble vitamin C.

[0021] The beneficial effects of the embodiments of the present invention include:

[0022] 1. As mentioned in the background section, the common method for achieving temperature-sensitive skincare products in the prior art is to add heat-sensitive agents. However, heat-sensitive agents significantly increase the risk of irritation. The inventors provide a temperature-sensitive composition that eliminates the need for traditional heat-sensitive agents, thus avoiding the irritation risks associated with their addition.

[0023] 2. When a certain amount of polyol comes into contact with the skin, it quickly absorbs moisture from the skin surface or the air. The polyol molecules bond with water molecules through hydrogen bonds, a process that releases heat and causes a local temperature rise. Based on this principle, the inventors attempted to achieve a warming effect by adding polyol. Experiments showed that only after adding a large amount of polyol (greater than 40%) could the user subjectively experience a comfortable and noticeable warming effect (the relative temperature difference was determined to be greater than 0.5℃ at this point). However, the composition exhibited some irritation due to the large amount of polyol added, therefore, the method of achieving a warming effect solely by adding a large amount of polyol was not feasible. The inventors unexpectedly discovered that combining low-concentration polyol (10-40% by mass) with fat-soluble vitamin C could provide a warming effect to the user. By combining fat-soluble vitamin C and polyol in a specific ratio, a warming effect could be provided to the user without causing irritation.

[0024] 3. According to experimental results, the temperature-sensing composition, including polyols and fat-soluble vitamin C, has a relatively short duration of temperature sensation, lasting only 21-71 seconds. The inventors further introduced tocopherol and its derivatives, increasing the duration of temperature sensation to 116-401 seconds, significantly extending the duration. Through the synergistic combination of specific proportions of fat-soluble vitamin C, polyols, and tocopherol and its derivatives, the temperature-sensing composition achieves a synergistic effect of prolonging the duration of temperature sensation without posing any risk of irritation. Attached Figure Description

[0025] Figure 1 The image shows a thermal image of the temperature sensing test in Comparative Example 6; P1 is the negative control group, P2 is the blank control group, and P3 is Comparative Example 6.

[0026] Figure 2 This is a thermal imaging image of the temperature sensing test in Example 5; P1 in the image is the negative control group, P2 is the blank control group, and P3 is Example 5.

[0027] Figure 3 The image shows a thermal imaging result of the temperature sensing test in Example 6; P1 represents the negative control group, P2 represents the blank control group, and P3 represents Example 6.

[0028] Figure 4 This is a thermal imaging image of the temperature sensing test in Example 7; P1 in the image is the negative control group, P2 is the blank control group, and P3 is Example 7.

[0029] Figure 5 The image shows a thermal image of the temperature sensing test for Comparative Example 15; P1 is the negative control group, P2 is the blank control group, and P3 is Comparative Example 15.

[0030] Figure 6 The image shows a thermal image of the temperature sensing test for Comparative Example 23; P1 is the negative control group, P2 is the blank control group, and P3 is Comparative Example 23.

[0031] Figure 7 The image shows a thermal imaging result of the temperature sensing test in Example 14; P1 is the negative control group, P2 is the blank control group, and P3 is Example 14.

[0032] Figure 8 The image shows a thermal imaging result of the temperature sensing test in Example 19; P1 is the negative control group, P2 is the blank control group, and P3 is Example 19.

[0033] Figure 9 The image shows a thermal imaging result of the temperature sensing test in Example 23; P1 is the negative control group, P2 is the blank control group, and P3 is Example 23. Detailed Implementation

[0034] The present application will now be described in further detail with reference to the accompanying drawings, so that those skilled in the art can implement it based on the description.

[0035] The term "warming sensation" refers to the comfortable and noticeable warming effect that a user can subjectively feel after applying cosmetics to the skin.

[0036] The term "solvent" refers to a substance that can dissolve polyols, temperature-sensitive additives, and thickeners, and form a homogeneous, stable, molecularly or ionicly dispersed homogeneous system with them.

[0037] The term "fat-soluble vitamin C" refers to fat-soluble derivatives of vitamin C.

[0038] The terms "first," "second," etc., used in the embodiments of this application are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first," "second," etc., may explicitly or implicitly include at least one of that feature.

[0039] Furthermore, the terms “comprising,” “containing,” “having,” and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the steps or units listed, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to such process, method, product, or apparatus.

[0040] When a numerical range is involved, the numerical range includes the endpoint values ​​at both ends. For example, the numerical range A~B includes not only the values ​​within A~B, but also the values ​​at the endpoints A and B.

[0041] In addition to the above, it should be emphasized that the reference to "embodiment" herein means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0042] <Temperature-sensing composition>

[0043] In some embodiments, a temperature-sensitive composition comprising fat-soluble vitamin C is provided, comprising a polyol, a temperature-sensitive aid, a thickener, and a solvent; the temperature-sensitive aid comprises a first temperature-sensitive component, the first temperature-sensitive component being fat-soluble vitamin C; the temperature-sensitive composition comprises, based on a total mass fraction of 100 parts:

[0044] 10-40 parts of polyols, and

[0045] 0.02~2 parts of the first temperature-sensing component.

[0046] In some embodiments, the composition can achieve the following technical effects:

[0047] 1. As mentioned in the background section, the common method for achieving temperature-sensitive skincare products in the prior art is to add temperature-sensitive agents. However, these agents significantly increase the risk of irritation. This invention provides a temperature-sensitive composition that eliminates the need for traditional temperature-sensitive agents, thus avoiding the irritation risks associated with their addition.

[0048] 2. When a certain amount of polyol comes into contact with the skin, it quickly absorbs moisture from the skin surface or the air. The polyol molecules bond with water molecules through hydrogen bonds, a process that releases heat and causes a local temperature rise. Based on this principle, the inventors attempted to achieve a warming effect by adding polyol. Experiments showed that only after adding a large amount of polyol (greater than 40%) could the user subjectively experience a comfortable and noticeable warming effect; the relative temperature difference at this point was determined to be greater than 0.5℃. However, the composition exhibited some irritation due to the large amount of polyol added, therefore, the method of achieving a warming effect solely by adding a large amount of polyol was not feasible. The inventors unexpectedly discovered that combining a low concentration of polyol (10-40% by mass) with fat-soluble vitamin C could provide a warming effect without causing irritation. The inventors speculated that this might be because fat-soluble vitamin C interacts weakly with polyol molecules (hydrogen bonds or van der Waals forces), increasing the effective local concentration of polyol on the skin surface and the efficiency of hydrogen bond formation.

[0049] In some embodiments, the polyol is one or both of glycerol and butylene glycol.

[0050] In some embodiments, the fat-soluble vitamin C is one or more of ascorbate tetraisopalmitate, ascorbate stearate, ascorbate palmitate, tetrahexyldecyl ascorbate, and ascorbate dipalmitate.

[0051] In some embodiments, the thickener is one or more of the following: ammonium polyacrylamide dimethyl taurate, ammonium acrylamide dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate / sodium acrylamide dimethyl taurate copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, hydroxyethyl cellulose, carrageenan, gellan gum, sodium acrylate copolymer, sodium magnesium lithium silicate, sodium carbomer, sodium polyacrylate, polyacrylate crosspolymer-6, and microcrystalline cellulose.

[0052] In some embodiments, the temperature-sensitive composition includes 0.2-1 part thickener.

[0053] In some embodiments, the solvent is one or more of the following: rose water, rose hydrosol, calendula water, calendula hydrosol, honeysuckle water, honeysuckle hydrosol, rice fermentation filtrate, coffee fermentation filtrate, yeast fermentation filtrate, and lactobacillus fermentation filtrate.

[0054] In some embodiments, the temperature-sensing additive further includes a second temperature-sensing component, which is tocopherol and / or a tocopherol derivative.

[0055] Experiments have shown that, based on the combination of polyols and fat-soluble vitamin C mentioned above, the further introduction of vitamin E and its derivatives can significantly prolong the duration of the warming sensation.

[0056] In some embodiments, the tocopherol derivative is one or more of tocopherol acetate, tocopherol succinate, tocopherol phosphate, tocopherol nicotinate, tocopherol linoleate, tocopherol palmitate, and tocopherol linoleate / oleate. Preferably, the tocopherol derivative is tocopherol acetate and / or tocopherol nicotinate.

[0057] In some embodiments, when the temperature-sensing additive includes a second temperature-sensing component, the temperature-sensing composition includes:

[0058] 10-40 parts of polyols,

[0059] 0.2~2 parts of the first temperature-sensing component, and

[0060] 0.05 to 5 parts of the second temperature-sensitive component.

[0061] In some embodiments, the second warming ingredient is one or both of tocopheryl acetate and tocopherol. This can provide users with a longer-lasting warming effect without posing a risk of irritation.

[0062] In some embodiments, the second temperature-sensing agent is tocopheryl nicotinic acid ester, and the mass fraction of the second temperature-sensing agent is 0.05 to 2 parts. This can provide users with a longer-lasting temperature-sensing effect without posing a risk of irritation.

[0063] <Preparation method of temperature-sensitive composition containing fat-soluble vitamin C>

[0064] In a second aspect, the present invention also provides a method for preparing the temperature-sensitive composition comprising fat-soluble vitamin C of the first aspect, comprising the following steps:

[0065] Disperse the solvent and thickener evenly in the main reaction vessel, heat to the first temperature and stir homogenously until uniform;

[0066] Add the polyol to the main reaction vessel, stir well, and cool to the second temperature.

[0067] The temperature-sensitive additive was added to the main reaction vessel, homogenized and stirred until uniform, and then cooled to the third temperature to obtain the composition.

[0068] In some embodiments, the first temperature is 80~85°C; preferably, it is 85°C.

[0069] In some embodiments, the second temperature is 45~55°C; preferably, it is 50°C.

[0070] In some embodiments, the third temperature is room temperature.

[0071] <New Uses for Fat-Soluble Vitamin C>

[0072] This invention provides the application of fat-soluble vitamin C as a temperature-sensitive adjuvant in the preparation of topical skin preparations, which include polyols.

[0073] In some embodiments, the mass fraction of the polyol is 10-40%. Preferably, it is 10-30%, or 10-25%, or 25-40%, or 30-40%, or 40%, or 25%, or 10%, or 30%.

[0074] In some embodiments, the mass fraction of fat-soluble vitamin C is 0.02-2%; preferably, it is 0.2-2%, or 0.05-2%, or 0.1-2%, or 1-2%, or 0.02-1%, or 0.2-1%, or 0.02%, or 0.2%, or 1%, or 1.5%, or 2%.

[0075] In some embodiments, the topical skin agent is one of the following: lotion, emulsion, foundation, hand cream, serum, shampoo, conditioner, hair conditioner, styling agent, and face mask.

[0076] In some embodiments, the topical skin agent may further include one or more of the following: antioxidants, whitening agents, anti-inflammatory agents, stabilizers, surfactants, lubricants, buffers, humectants, pH adjusters, excipients, dispersants, preservatives, solubilizers, moisturizers, and ultraviolet absorbers.

[0077] <New Uses of Tocopherol and its Derivatives>

[0078] This invention provides the application of tocopherol and its derivatives as temperature-sensitive adjuvants in the preparation of topical skin preparations, which include polyols and fat-soluble vitamin C.

[0079] In some embodiments, the mass fraction of the polyol is 10-40%. Preferably, it is 10-30%, or 10-25%, or 25-40%, or 30-40%, or 40%, or 25%, or 10%, or 30%.

[0080] In some embodiments, the mass fraction of fat-soluble vitamin C is 0.02-2%; preferably, it is 0.2-2%, or 0.05-2%, or 0.1-2%, or 1-2%, or 0.02-1%, or 0.2-1%, or 0.02%, or 0.2%, or 1%, or 1.5%, or 2%.

[0081] In some embodiments, the topical skin agent includes tocopherol and its derivatives, and the mass fraction of fat-soluble vitamin C is 0.05-5%; preferably, it is 0.1-5%, or 0.5-5%, or 1-5%, or 1-5%, or 0.05-2%, or 0.05-1%, or 0.05-3%, or 0.05-4%.

[0082] In some embodiments, the topical skin agent is one of the following: lotion, emulsion, foundation, hand cream, serum, shampoo, conditioner, hair conditioner, styling agent, and face mask.

[0083] In some embodiments, the topical skin agent may further include one or more of the following: antioxidants, whitening agents, anti-inflammatory agents, stabilizers, surfactants, lubricants, buffers, humectants, pH adjusters, excipients, dispersants, preservatives, solubilizers, moisturizers, and ultraviolet absorbers.

[0084] <Preparation of Comparative Examples 1-14 and Examples 1-13>

[0085] The composition of the compositions provided in Comparative Examples 1-14 and Examples 1-13 is shown in Table 1 below.

[0086] Table 1. Composition of the compositions provided in Comparative Examples 1-14 and Examples 1-13

[0087] In the table,

[0088] VC-IP is an abbreviation for ascorbic acid tetraisopalmitate;

[0089] VCE is an abbreviation for Vitamin C Ethyl Ether;

[0090] AP is an abbreviation for ascorbyl palmitate;

[0091] The thickener is ammonium polyacrylamide dimethyl taurate;

[0092] The solvent is deionized water.

[0093] The specific preparation methods of the compositions in Comparative Examples 1-14 and Examples 1-13 are as follows:

[0094] Preparation of Comparative Example 1

[0095] Comparative Example 1

[0096] In Comparative Example 1, the composition was prepared according to the following steps:

[0097] The solvent and thickener are dispersed evenly in the main reaction vessel, heated to 80°C and stirred evenly, and then cooled to room temperature (25°C) to obtain the composition.

[0098] Preparation of Comparative Examples 2-7

[0099] Comparative Example 2

[0100] In Comparative Example 2, the composition was prepared according to the methods shown in steps S101-S102 below:

[0101] S101. Disperse the solvent and thickener evenly in the main reaction vessel, heat to 80°C and stir evenly.

[0102] S102. Add the polyol to the main reaction vessel, stir evenly, and cool to room temperature (25°C) to obtain the composition.

[0103] The polyol is glycerol, with a mass fraction of 50%.

[0104] Comparative Example 3

[0105] The composition in Comparative Example 3 was prepared in the same way as that in Comparative Example 2, except that the polyol was butanediol with a mass fraction of 45%.

[0106] Comparative Example 4

[0107] The composition in Comparative Example 4 was prepared in the same way as that in Comparative Example 2, except that the polyol was butanediol with a mass fraction of 50%.

[0108] Comparative Example 5

[0109] The composition in Comparative Example 5 was prepared in the same way as that in Comparative Example 2, except that the polyols were glycerol and butanediol, with glycerol having a mass fraction of 35% and butanediol having a mass fraction of 10%.

[0110] Comparative Example 6

[0111] The composition in Comparative Example 6 was prepared in the same way as that in Comparative Example 2, except that the polyol was glycerol and the mass fraction of glycerol was 40%.

[0112] Comparative Example 7

[0113] The composition in Comparative Example 7 was prepared in the same way as that in Comparative Example 2, except that the polyol was butanediol and the mass fraction of butanediol was 40%.

[0114] Preparation of Comparative Examples 8-14

[0115] Comparative Example 8

[0116] In Comparative Example 8, the composition was prepared according to the steps S201-S203 as follows:

[0117] S201. Disperse the solvent and thickener evenly in the main reaction vessel, heat to 80 degrees Celsius and stir homogenously until uniform;

[0118] S202. Add the polyol to the main reaction vessel, stir well, and cool to 50°C.

[0119] S203. Add the temperature-sensitive agent to the main reaction vessel, stir homogenously until uniform, and cool to room temperature to obtain the composition;

[0120] in,

[0121] The polyol is propylene glycol, with a mass fraction of 10%.

[0122] The temperature-sensing agent is the primary temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 0.02%.

[0123] Comparative Example 9

[0124] The composition in Comparative Example 9 was prepared in the same way as that in Comparative Example 8, except that the polyol was pentanediol and the mass fraction of pentanediol was 10%.

[0125] Comparative Example 10

[0126] The composition in Comparative Example 10 was prepared in the same way as that in Comparative Example 8, except that the polyols were pentanediol and hexanediol, with pentanediol having a mass fraction of 10% and hexanediol having a mass fraction of 5%; and the temperature-sensitive agent was the first temperature-sensitive component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0127] Comparative Example 11

[0128] The composition in Comparative Example 11 was prepared in the same way as that in Comparative Example 8, except that the polyols were pentylene glycol and butylene glycol, with pentylene glycol having a mass fraction of 5% and butylene glycol having a mass fraction of 30%; the temperature-sensitive agent was the first temperature-sensitive component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0129] Comparative Example 12

[0130] The composition in Comparative Example 12 was prepared in the same way as that in Comparative Example 8, except that the polyols were hexanediol and glycerol, with hexanediol having a mass fraction of 5% and glycerol having a mass fraction of 30%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0131] Comparative Example 13

[0132] The composition in Comparative Example 13 was prepared in the same way as that in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; and the temperature-sensitive agent was vitamin C ethyl ether (VCE) with a mass fraction of 2%.

[0133] Comparative Example 14

[0134] The composition in Comparative Example 14 was prepared in the same way as that in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 2.5%.

[0135] Preparation of Examples 1-13

[0136] Example 1

[0137] The composition in Example 1 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 10%; and the temperature-sensing agent was the first temperature-sensing component, ascorbate palmitate (AP), with a mass fraction of 0.02%.

[0138] Example 2

[0139] The composition in Example 2 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; and the temperature-sensing agent was the first temperature-sensing component, ascorbate palmitate (AP), with a mass fraction of 2%.

[0140] Example 3

[0141] The composition in Example 3 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol, the mass fraction of glycerol was 10%, and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid stearate, with a mass fraction of 0.02%.

[0142] Example 4

[0143] The composition in Example 4 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol, the mass fraction of glycerol was 40%, and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid stearate, with a mass fraction of 2%.

[0144] Example 5

[0145] The composition in Example 5 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 10%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 0.02%.

[0146] Example 6

[0147] The composition in Example 6 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 30%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0148] Example 7

[0149] The composition in Example 7 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 2%.

[0150] Example 8

[0151] The composition in Example 8 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 25%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0152] Example 9

[0153] The composition in Example 9 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 35%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0154] Example 10

[0155] The composition in Example 10 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 0.2%.

[0156] Example 11

[0157] The composition in Example 11 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 10% and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 0.02%.

[0158] Example 12

[0159] The composition in Example 12 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 30%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 1%.

[0160] Example 13

[0161] The composition in Example 13 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 40%; and the temperature-sensing agent was the first temperature-sensing component, ascorbic acid tetraisopalmitate (VC-IP), with a mass fraction of 2%.

[0162] <Preparation of Comparative Examples 15-24 and Examples 14-26>

[0163] The composition of the compositions provided in Comparative Examples 15-24 and Examples 14-26 is shown in Table 2 below.

[0164] Table 2. Composition of the compositions provided in Comparative Examples 15-24 and Examples 14-26

[0165]

[0166] In the table,

[0167] VC-IP is an abbreviation for ascorbic acid tetraisopalmitate;

[0168] The thickener is ammonium polyacrylamide dimethyl taurate;

[0169] The solvent is deionized water.

[0170] The specific preparation methods of the compositions in Comparative Examples 15-24 and Examples 14-26 are as follows:

[0171] Preparation of Comparative Examples 15-16

[0172] Comparative Example 15

[0173] In Comparative Example 15, the composition was prepared according to the methods shown in steps S301-S302 below:

[0174] S301. Disperse the solvent and thickener evenly in the main reaction vessel, heat to 80 degrees Celsius and stir homogenously until uniform, then cool to 50 degrees Celsius.

[0175] S302. Add the temperature-sensitive agent to the main reaction vessel and stir homogenously to obtain the composition.

[0176] The temperature-sensing agent is the second temperature-sensing component, tocopherol (VE), with a mass fraction of 5%.

[0177] Comparative Example 16

[0178] The composition in Comparative Example 16 was prepared in the same way as that in Comparative Example 15, except that the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE). The mass fraction of ascorbate tetraisopalmitate (VC-IP) was 1% and the mass fraction of tocopherol (VE) was 0.5%.

[0179] Preparation of Comparative Examples 17-24

[0180] Comparative Example 17

[0181] The composition in Comparative Example 17 was prepared in the same way as that in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 10%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 1% for ascorbate tetraisopalmitate (VC-IP) and 0.02% for tocopherol (VE).

[0182] Comparative Example 18

[0183] The composition in Comparative Example 18 was prepared in the same way as that in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 10%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopheryl acetate with a mass fraction of 1% and 0.02%.

[0184] Comparative Example 19

[0185] The composition in Comparative Example 19 was prepared in the same way as that in Comparative Example 8, except that the polyols were glycerol and butanediol, with glycerol having a mass fraction of 30% and butanediol having a mass fraction of 10%; the temperature-sensing agents were the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with ascorbate tetraisopalmitate (VC-IP) having a mass fraction of 0.2% and tocopherol acetate having a mass fraction of 6%.

[0186] Comparative Example 20

[0187] The composition in Comparative Example 20 was prepared in the same way as that in Comparative Example 8, except that the polyols were glycerol and butylene glycol, with glycerol having a mass fraction of 35% and butylene glycol having a mass fraction of 5%; the temperature-sensing agents were the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with ascorbate tetraisopalmitate (VC-IP) having a mass fraction of 0.2% and tocopherol acetate having a mass fraction of 0.02%.

[0188] Comparative Example 21

[0189] The composition in Comparative Example 21 was prepared in the same way as that in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 10%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tococelen with a mass fraction of 0.2% for ascorbate tetraisopalmitate (VC-IP) and 0.05% for tococelen.

[0190] Comparative Example 22

[0191] The composition in Comparative Example 22 was prepared in the same way as that in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 10%; the temperature-sensitive agent was the first temperature-sensitive component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensitive component tocopheryl nicotinate, with a mass fraction of 0.02% for ascorbate tetraisopalmitate (VC-IP) and 0.05% for tococelen.

[0192] Comparative Example 23

[0193] The composition in Comparative Example 23 was prepared in the same way as that in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 10%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 0.05% for ascorbate tetraisopalmitate (VC-IP) and 5% for tocopherol (VE).

[0194] Comparative Example 24

[0195] The composition in Comparative Example 24 was prepared in the same way as that in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 30%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 0.02% for ascorbate tetraisopalmitate (VC-IP) and 5% for tocopherol (VE).

[0196] Preparation in Examples 14-26

[0197] Example 14

[0198] The composition in Example 14 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tococelen with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 5% for tococelen.

[0199] Example 15

[0200] The composition in Example 15 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopheryl nicotinate, with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 5% for tocopheryl nicotinate.

[0201] Example 16

[0202] The composition in Example 16 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopheryl nicotinate, with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 5% for tocopheryl nicotinate.

[0203] Example 17

[0204] The composition in Example 17 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 30%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopheryl nicotinate with a mass fraction of 2% for both ascorbate tetraisopalmitate (VC-IP) and tocopheryl nicotinate.

[0205] Example 18

[0206] The composition in Example 18 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopheryl nicotinate, with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 0.5% for tocopheryl nicotinate.

[0207] Example 19

[0208] The composition in Example 19 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 40%; the temperature-sensitive agent was the first temperature-sensitive component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensitive component tocopheryl nicotinate, with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 0.5% for tocopheryl nicotinate.

[0209] Example 20

[0210] The composition in Example 20 was prepared in the same way as in Comparative Example 8, except that the polyols were glycerol and butylene glycol, with glycerol having a mass fraction of 35% and butylene glycol having a mass fraction of 5%; the temperature-sensing agents were the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopheryl acetate, with ascorbate tetraisopalmitate (VC-IP) having a mass fraction of 0.2% and tocopheryl acetate having a mass fraction of 0.05%.

[0211] Example 21

[0212] The composition in Example 21 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 10%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 1% for ascorbate tetraisopalmitate (VC-IP) and a mass fraction of 0.5% for tocopherol acetate.

[0213] Example 22

[0214] The composition in Example 22 was prepared in the same way as in Comparative Example 8, except that the polyol was butanediol with a mass fraction of 10%; the temperature-sensitive agent was the first temperature-sensitive component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensitive component tocopheryl acetate with a mass fraction of 1% and a mass fraction of 0.5% for tocopherol (VE).

[0215] Example 23

[0216] The composition in Example 23 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 5% for tocopherol acetate.

[0217] Example 24

[0218] The composition in Example 24 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 2% for ascorbate tetraisopalmitate (VC-IP) and 5% for tocopherol (VE).

[0219] Example 25

[0220] The composition in Example 25 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 30%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 1% for ascorbate tetraisopalmitate (VC-IP) and 1% for tocopherol acetate.

[0221] Example 26

[0222] The composition in Example 26 was prepared in the same way as in Comparative Example 8, except that the polyol was glycerol with a mass fraction of 40%; the temperature-sensing agent was the first temperature-sensing component ascorbate tetraisopalmitate (VC-IP) and the second temperature-sensing component tocopherol (VE), with a mass fraction of 1% for ascorbate tetraisopalmitate (VC-IP) and 0.05% for tocopherol (VE).

[0223] <Skin Temperature Sensitivity Test Method>

[0224] Under constant temperature and humidity conditions of 25°C and 60%, test areas were randomly selected. 200 μl of the sample was pipetted onto a 0.5 cm × 0.5 cm wet compress and then applied to the inside of the subject's forearm. The initial temperature and start time of the experiment were recorded. A negative control group, a blank control group, and an experimental group were set up on each subject's arm. The negative control group was treated with the composition provided in Comparative Example 1 (i.e., the solvent in the table), the blank control group received no treatment, and the experimental group was treated with the compositions provided in Comparative Examples 2-24 and Examples 1-26, respectively. The temperature difference (relative temperature difference) between the experimental group and the negative control group was examined, and the duration of the temperature difference > 0.5°C was recorded. Through multiple experiments, the inventors determined that at a room temperature of 25°C, when the temperature difference > 0.5°C, the subject could feel a noticeable warming sensation; when the temperature difference was less than 0.5°C, the subject could not feel a noticeable warming sensation.

[0225] <Open-ended, immediate stimulus assessment method>

[0226] Five people were randomly selected for testing. The test site was the inner side of the forearm. After washing with clean water and drying for 30 minutes, 500 μl of the test substance was randomly applied to the inner side of the forearm using a pipette. The sample prepared according to the aforementioned embodiment or comparative example was evenly applied to a 2cm*2cm area of ​​skin with the fingertip. The skin reaction was observed at 5 min and 30 min according to the standards in the table below, and the observation results were recorded. The scoring rules are shown in Table 3. The final score data is the average score of the five people.

[0227] Table 3 Scoring Rules

[0228] <Experimental Example 1: Temperature Sensitivity Test and Open Immediate Stimulation Test of Comparative Examples 1-7 and Examples 1-9>

[0229] This experimental example tested the warming effect and irritation produced by the compositions provided in Comparative Examples 1-7 and Examples 1-9 when applied to the skin. The skin warming test method and the open-label immediate irritation assessment method described above were used in the experiment. The experimental results are shown in Table 4 below.

[0230] Table 4. Experimental test results of Comparative Examples 1-7 and Examples 1-9

[0231] (1) Regarding Comparative Examples 2-7

[0232] As shown in Table 4, the results of the temperature sensation test indicate that the relative temperature difference between the compositions provided in Comparative Examples 2-5 and the negative control group (the composition provided in Comparative Example 1) after application to the skin is greater than 0.5℃, meaning that the subjects could subjectively experience a comfortable and noticeable warming effect. However, according to the open-label immediate irritation test results, the compositions provided in Comparative Examples 2-5 caused some irritation to the subjects' skin after 5 minutes and 30 minutes of application. The difference between Comparative Examples 2-5 and the negative control group is that Comparative Examples 2-5 added 45-50% polyols, including glycerin and / or butylene glycol. Therefore, the addition of 45-50% polyols can provide a warming effect to the subjects' skin, but it also significantly increases the risk of irritation.

[0233] As shown in Table 4, the temperature sensation test results indicate that the relative temperature difference between the compositions provided in Comparative Examples 6-7 and the negative control group after application to the skin was less than 0.5℃, especially in Comparative Example 6, where the relative temperature difference was -0.2℃, failing to produce a temperature sensation effect. Simultaneously, the open-label immediate irritation test results show that the compositions provided in Comparative Examples 6-7 did not cause discomfort to the subjects after application to the skin. The comparison shows that the only difference between Comparative Examples 2-4 and Comparative Examples 6-7 is that the amount of glycerin and / or butylene glycol added in Comparative Examples 6-7 is lower than that in Comparative Examples 2-4. Therefore, reducing the amount of polyols added can reduce the risk of irritation, but it cannot produce a temperature sensation effect.

[0234] (2) Comparison between Comparative Examples 6-7 and Examples 1-13

[0235] As shown in Table 4, the results of the temperature sensation test indicate that the relative temperature difference between the compositions provided in Examples 1-13 and the negative control group after application to the skin is greater than 0.5℃, meaning that the subjects can subjectively experience a comfortable and noticeable warming effect. Simultaneously, the results of the open-label immediate irritation test show that the subjects did not experience discomfort after 5 minutes and 30 minutes of application to the skin with the compositions provided in Examples 1-13. A comparison shows that the only difference between Examples 1-13 and Comparative Examples 6-7 is that Examples 1-13 also include the addition of the first temperature-sensing component, fat-soluble vitamin C. Therefore, the combination of polyols and fat-soluble vitamin C has a synergistic effect, providing a warming effect to the subjects' skin without posing a risk of irritation.

[0236] (3) Comparison of Comparative Examples 8-12 and Examples 1-13

[0237] As shown in Table 4, the results of the temperature sensation test indicate that the relative temperature difference between the compositions provided in Comparative Examples 8-12 and the negative control group (the composition provided in Comparative Example 1) after application to the skin is less than 0.5℃, meaning that a temperature sensation effect cannot be produced. Simultaneously, the results of the open-label immediate irritation test show that the compositions provided in Comparative Examples 8-12 caused discomfort to the subjects 5 minutes and 30 minutes after application to the skin. A comparison reveals that the difference between Examples 1-13 and Comparative Examples 8-12 lies in the polyols used: Comparative Example 8 uses propylene glycol, Comparative Example 9 uses pentylene glycol, Comparative Example 10 uses pentylene glycol and hexanediol, Comparative Example 11 uses pentylene glycol and butylene glycol, Comparative Example 12 uses hexanediol and glycerin, and Examples 1-13 use glycerin and / or butylene glycol. Therefore, it can be concluded that at least when the polyol in the composition is glycerin and / or butylene glycol, a temperature sensation effect can be provided to the subject's skin without posing a risk of irritation.

[0238] (4) Comparison between Comparative Example 13 and Example 2

[0239] As shown in Table 4, the temperature-sensing test results indicate that the composition provided in Comparative Example 13, when applied to the skin, showed a relative temperature difference of less than 0.5°C and -0.3°C compared to the negative control group (the composition provided in Comparative Example 1), which was lower than the temperature of the negative control group, meaning it could not produce a temperature-sensing effect. The difference between Comparative Example 13 and Example 2 lies in the type of Vitamin C used; Comparative Example 13 used 3-O-ethyl ascorbic acid ether (VCE), a water-soluble form of Vitamin C. Therefore, it can be concluded that at least when the first temperature-sensing component in the composition is fat-soluble Vitamin C, it can provide a temperature-sensing effect to the subjects without posing a risk of irritation.

[0240] (5) Regarding the mass ratio of a specific combination including polyols and fat-soluble vitamin C, the first temperature-sensitive component.

[0241] As shown in Table 4, the results of the temperature sensation test indicate that the compositions provided in Examples 1-13, when applied to the skin, exhibited a relative temperature difference greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), with a duration of 21-71 seconds. This indicates a comfortable and noticeable warming effect that the subjects could subjectively perceive. Furthermore, the results of the open-label immediate irritation test show that the compositions provided in Examples 1-13 did not cause discomfort to the subjects 5 minutes and 30 minutes after application to the skin. Therefore, it can be concluded that, at least in specific combinations of fat-soluble vitamin C and polyols such as glycerin and / or butylene glycol, when the mass ratio of fat-soluble vitamin C to polyols is 0.02-2:10-40, a warming effect can be achieved in the subjects without posing an irritation risk.

[0242] As shown in Table 4, the results of the temperature sensation test indicate that the composition provided in Comparative Example 14, when applied to the skin, exhibits a relative temperature difference greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), thus producing a warming effect. Simultaneously, the results of the open-label immediate irritation test show that subjects experienced discomfort after applying the composition to the skin for 5 minutes and 30 minutes. The composition provided in Example 7, when applied to the skin, exhibits a relative temperature difference greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), thus producing a warming effect. Simultaneously, the results of the open-label immediate irritation test show that subjects did not experience discomfort after applying the composition to the skin for 5 minutes and 30 minutes. The difference between Comparative Example 14 and Example 7 lies in the amount of fat-soluble vitamin C added; Comparative Example 14 has a mass fraction greater than 2 parts. Therefore, it can be concluded that, at least when the mass fraction of fat-soluble vitamin C is less than or equal to 2 parts, a specific combination of polyols, including glycerol and / or butylene glycol, and fat-soluble vitamin C does not pose an irritation risk.

[0243] According to the test results of Examples 1-13, the first temperature-sensitive component, fat-soluble vitamin C, can be at least one of ascorbate palmitate, ascorbate stearate, and ascorbate tetraisopalmitate (VC-IP).

[0244] As mentioned in the background section, the common method for achieving temperature-sensitive skincare products in the prior art is to add temperature-sensitive agents. However, these agents significantly increase the risk of irritation. The inventors provide a temperature-sensitive composition that eliminates the need for traditional temperature-sensitive agents, thus avoiding the irritation risks associated with their addition.

[0245] When a certain amount of polyol comes into contact with the skin, it rapidly absorbs moisture from the skin surface or the air. The polyol molecules bond with water molecules through hydrogen bonds, a process that releases heat and causes a local temperature rise. Based on this principle, the inventors attempted to achieve a warming effect by adding polyol. Experiments showed that only after adding a large amount of polyol (greater than 40%) could the user subjectively experience a comfortable and noticeable warming effect (the relative temperature difference was determined to be greater than 0.5℃ at this point). However, the composition exhibited some irritation due to the large amount of polyol added, making the method of achieving a warming effect solely through adding a large amount of polyol impractical. The inventors unexpectedly discovered that combining low-concentration polyol (10-40% by mass) with fat-soluble vitamin C could provide a warming effect. By combining fat-soluble vitamin C and polyol in a specific ratio, a warming effect could be achieved without causing irritation.

[0246] <Experimental Example 2: Temperature Sensitivity Test and Open Immediate Stimulation Test of Comparative Examples 15-24 and Examples 14-26>

[0247] This experimental example tested the warming effect and irritation produced by the compositions provided in Comparative Examples 15-27 and Examples 14-26 when applied to the skin. The skin warming test method and the open-label immediate irritation assessment method described above were used in the experiments. The experimental results are shown in Table 5 below.

[0248] Table 5. Experimental test results of Comparative Examples 15-27 and Examples 14-26

[0249] (1) Comparison of Comparative Examples 15-16, Example 7 and Example 19

[0250] As shown in Table 5, the results of the temperature sensation test show that the compositions provided in Comparative Examples 15-16, when applied to the skin, exhibit a relative temperature difference of less than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), thus producing a temperature sensation. As shown in Table 4, the composition provided in Example 7, when applied to the skin, exhibits a relative temperature difference of greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), meaning the subject can subjectively experience a comfortable and noticeable warming effect; the duration of the temperature sensation is 55 seconds. As shown in Table 5, the composition provided in Example 21, when applied to the skin, exhibits a relative temperature difference of greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), thus producing a temperature sensation; the duration of the temperature sensation is 187 seconds, significantly longer than that of Example 7. A comparison reveals that the differences between Comparative Examples 15-16, Example 7, and Example 21 are as follows: Comparative Example 15's composition includes only the second temperature-sensitive component, tocopherol; Comparative Example 16's composition includes only the first temperature-sensitive component, fat-soluble vitamin C, and the second temperature-sensitive component, tocopherol; Example 7's composition includes a polyol and the first temperature-sensitive component, fat-soluble vitamin C; and Example 21 includes the first temperature-sensitive component, fat-soluble vitamin C, a polyol, and the second temperature-sensitive component, fat-soluble vitamin C, tocopherol. Therefore, the combination of fat-soluble vitamin C, polyol, and tocopherol can provide subjects with a longer temperature-sensitive effect without posing a risk of irritation.

[0251] (2) Comparison of Examples 7, 14, 15 and 20

[0252] As shown in Table 4, the composition provided in Example 7, when applied to the skin, showed a relative temperature difference greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), and the duration of the warming sensation was 55 seconds. As shown in Table 5, the compositions provided in Examples 14-15 and 20, when applied to the skin, showed a relative temperature difference greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1), thus producing a warming effect. The duration of the warming sensation in Example 14 was 89 seconds, in Example 15 it was 218 seconds, and in Example 20 it was 116 seconds. The duration of the warming sensation in Examples 14-15 and 20 was longer than that in Example 7. A comparison shows that the difference between Examples 7, 14, 15, and 20 is that the composition in Example 7 included the first warming component, fat-soluble vitamin C, and a polyol; while Examples 14, 15, and 20 included the first warming component, fat-soluble vitamin C, a polyol, and the second warming component, tocopherol derivatives (tocoxexyl, tocopheryl nicotinate, and tocopheryl acetate). Therefore, it can be seen that the combination of fat-soluble vitamin C, polyols and tocopherol derivatives can achieve a synergistic effect of prolonging the duration of temperature sensation.

[0253] As shown in Table 4, the results of the open-label immediate irritation test indicate that the composition provided in Example 14 caused discomfort to subjects 5 minutes and 30 minutes after application to the skin. The results of the open-label immediate irritation test in Examples 15 and 22 indicate that the compositions provided in Examples 15 and 22 did not cause discomfort to subjects 5 minutes and 30 minutes after application to the skin. Therefore, it can be concluded that, at least when the specific tocopherol derivatives are tocopheryl nicotinate and tocopheryl acetate, the combination of fat-soluble vitamin C, polyols, and tocopherol derivatives can achieve a synergistic effect of prolonging the duration of thermal sensation without posing an irritation risk.

[0254] (3) The mass ratio of a specific combination of the first temperature-sensitive component, fat-soluble vitamin C, polyol, and the second temperature-sensitive component, tocopherol and its derivatives.

[0255] As shown in Table 5, according to the temperature sensation test results, the compositions provided in Examples 15-26, when applied to the skin, showed a relative temperature difference greater than 0.5°C compared to the negative control group (the composition provided in Comparative Example 1). This means that the subjects could subjectively experience a comfortable and noticeable warming effect, with a duration of 116-401 seconds, which is longer than the duration of the warming effect in Examples 1-13 (21-71 seconds). Therefore, it can be concluded that at least when the mass ratio of fat-soluble vitamin C, polyols, and tocopherols and their derivatives is 0.2-2:10-40:0.05-5, a prolonged warming effect can be achieved in the subjects.

[0256] As shown in Table 5, when the second temperature-sensing component is tocopherol or tocopheryl acetate, the compositions provided in Examples 20-26 exhibit a temperature-sensing duration of 116-401 seconds, and subjects do not experience discomfort after 5 minutes and 30 minutes of application to the skin. The compositions provided in Comparative Example 19 cause discomfort after 5 minutes and 30 minutes of application to the skin. Comparative Examples 17-18, 20, and 23-24 exhibit a temperature-sensing duration of 5-45 seconds. The differences between Examples 17-19, 17-20, and 23-24 are as follows: in Comparative Example 19, the second temperature-sensing component is greater than 6 parts; in Comparative Examples 17-18 and 20, the second temperature-sensing component is less than 0.05 parts; and in Comparative Examples 23-24, the first temperature-sensing component is less than 0.2 parts. Therefore, when the second temperature-sensing agent is tocopherol and / or tocopherol acetate, at least when the mass ratio of fat-soluble vitamin C, polyol and the second temperature-sensing agent is 0.2~2:10~40:0.05~5, a synergistic effect of prolonging the temperature-sensing duration can be achieved without causing irritation.

[0257] As shown in Table 5, when the second temperature-sensing adjuvant is tocopherol nicotinic acid ester, the temperature-sensing duration of the compositions provided in Examples 17-19 is 192-312 seconds, and subjects do not experience discomfort after 5 minutes and 30 minutes of application to the skin. Subjects experience discomfort after 5 minutes and 30 minutes of application to the skin with the compositions provided in Examples 15-16. The temperature-sensing duration of the composition provided in Comparative Example 22 is 62 seconds. The difference between Examples 15-16, Examples 17-19, and Comparative Example 22 is that the mass fraction of the second temperature-sensing adjuvant in Examples 15-16 is greater than 2 parts, while the mass fraction of the first temperature-sensing component in Comparative Example 22 is less than 0.2 parts. Therefore, when the second temperature-sensing adjuvant is tocopherol nicotinic acid ester, at least when the mass fraction ratio of fat-soluble vitamin C, polyol, and tocopherol nicotinic acid ester is 0.2~2:10~40:0.05~2, a synergistic effect of prolonging the temperature-sensing duration can be achieved without posing an irritation risk.

[0258] According to experimental results, the temperature-sensitive composition, including polyols and fat-soluble vitamin C, has a relatively short duration of temperature sensation, lasting only 21-71 seconds. The inventors further introduced tocopherol and its derivatives, increasing the duration of temperature sensation to 116-401 seconds, significantly extending the duration. Through the synergistic combination of specific proportions of fat-soluble vitamin C, polyols, and tocopherol and its derivatives, the temperature-sensitive composition achieves a synergistic effect of prolonging the duration of temperature sensation without posing any risk of irritation.

Claims

1. A temperature-sensitive composition comprising fat-soluble vitamin C, characterized in that, It includes polyols, temperature-sensitive additives, thickeners, and solvents; wherein the temperature-sensitive additives include a first temperature-sensitive component, which is fat-soluble vitamin C; The temperature-sensing composition includes: 10-40 parts of polyols, and 0.02~2 parts of the first temperature-sensitive component.

2. The temperature-sensing composition according to claim 1, characterized in that, The polyol is one or both of glycerol and butylene glycol.

3. The temperature-sensing composition according to claim 1, characterized in that, Fat-soluble vitamin C is one or more of ascorbate tetraisopalmitate, ascorbate stearate, ascorbate palmitate, tetrahexyldecyl ascorbate, and ascorbate dipalmitate.

4. The temperature-sensing composition according to claim 1, characterized in that, The thickener is one or more of the following: ammonium polyacrylamide dimethyl taurate, ammonium acrylamide dimethyl taurate / behenol polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate / sodium acrylamide dimethyl taurate copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, hydroxyethyl cellulose, carrageenan, gellan gum, sodium acrylate copolymer, sodium magnesium lithium silicate, sodium carbomer, sodium polyacrylate, polyacrylate crosspolymer-6, and microcrystalline cellulose.

5. The temperature-sensing composition according to claim 1, characterized in that, The temperature-sensing additive also includes a second temperature-sensing component, which is tocopherol and / or tocopherol derivatives.

6. The temperature-sensing composition according to claim 5, characterized in that, The temperature-sensing composition includes: 10-40 parts of polyols, 0.2~2 parts of the first temperature-sensing component, 0.05 to 5 parts of the second temperature-sensitive component.

7. The temperature-sensing composition according to claim 5, characterized in that, The tocopherol derivatives are one or more of the following: tocopherol acetate, tocopherol succinate, tocopherol phosphate, tocopherol nicotinate, tocopherol linoleate, tocopherol palmitate, and tocopherol linoleate / oleate.

8. The method for preparing the temperature-sensitive composition is as follows: Disperse the solvent and thickener evenly in the main reaction vessel, heat to the first temperature and stir homogenously until uniform; Add the polyol to the main reaction vessel, stir well, and cool to the second temperature. The temperature-sensitive additive was added to the main reaction vessel, homogenized and stirred until uniform, and then cooled to the third temperature to obtain the composition.

9. Application of fat-soluble vitamin C as a temperature-sensitive adjuvant in the preparation of topical skin preparations, which include polyols.

10. The application of tocopherol and its derivatives as temperature-sensitive adjuvants in the preparation of topical skin preparations, wherein the topical skin preparations include polyols and a first temperature-sensitive component, wherein the first temperature-sensitive component is fat-soluble vitamin C.

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