A wet wipe disinfectant solution and a method for preparing the same, and a disinfectant wet wipe

Abstract

The present application belongs to the technical field of disinfecting products, and particularly relates to a wet wipe disinfectant, a preparation method thereof and a disinfecting wet wipe. The wet wipe disinfectant comprises lactic acid, citric acid, sodium lactate, arginine fatty acid cationic and anionic salt, plant phenol polysaccharide composite wall material microcapsule, ethanol, propylene glycol, glycerol, decyl glucoside, chelating agent, sodium benzoate and deionized water. The arginine fatty acid cationic and anionic salt is prepared by salting arginine with various fatty acids, and the plant phenol polysaccharide composite wall material microcapsule is prepared by embedding a plant phenol core material with a composite wall material. The disinfecting wet wipe is prepared by loading the wet wipe disinfectant on a hydrophilic treated non-woven fabric, and has the advantages of good spreading property, stable component release, mild odor, stable storage, and good cleaning and disinfecting effect.

Description

Technical Field

[0001] This invention belongs to the field of disinfection products technology, specifically relating to a disinfectant wipe solution, its preparation method, and disinfectant wipes. Background Technology

[0002] Wet wipes, used for daily cleaning, wiping public places, maintaining home surfaces, and as portable hygiene products, are convenient to use, easy to carry, provide instant wiping, and require no additional solution. They are widely used for cleaning hands, tabletops, door handles, kitchen and bathroom countertops, the outer surfaces of children's products, and other frequently touched objects. As consumers' demands for hygiene, safety, comfort, and low irritation increase, wet wipe products have evolved from simple cleaning wipes to multi-functional products that combine cleaning, antibacterial, disinfecting, and moisturizing properties. Current wet wipe disinfectants typically rely on alcohols, quaternary ammonium salts, chlorine-containing compounds, peroxides, or biguanides to achieve disinfection. However, in practical use, it is still necessary to consider bactericidal efficiency, odor, skin comfort, liquid retention after opening, and compatibility with wet wipe substrates. Therefore, the mildness, stability, and effective release capacity of the formulation system are crucial factors affecting the quality of disinfectant wet wipes.

[0003] While existing alcohol-based wipes offer rapid effectiveness, the high volatility of alcohols leads to a decrease in liquid content after long-term storage and repeated opening, resulting in noticeable odors and a certain degree of irritation. Chlorine-based or strong oxidizing systems, while possessing strong bactericidal capabilities, suffer from strong odors, insufficient stability, and risks of corrosion or discoloration to some materials. Quaternary ammonium salts or biguanides are commonly used in wipes, but their active ingredients are easily affected by non-woven fibers, dirt, hard water ions, and other formulation components, leading to insufficient actual release during wiping and thus affecting surface disinfection. Furthermore, some wipe disinfectant solutions may exhibit turbidity, layering, active ingredient precipitation, odor changes, or sticky residue on the wipe surface during storage, making it difficult to simultaneously meet the application requirements of mildness, low odor, stability, and high efficiency.

[0004] To address the aforementioned issues, existing technologies have attempted to construct milder composite disinfection systems using organic acids, natural plant phenols, amino acid surfactants, hydrophilic humectants, nonionic surfactants, and microencapsulation technology. Organic acids can reduce the adaptability of microorganisms to their living environment, plant phenolic components have good membrane disturbance and antibacterial effects, amino acid fatty acid salts possess both surface activity and antibacterial synergistic potential, and microencapsulation helps reduce the volatilization of plant phenols, improve dispersion stability, and delay the release of active ingredients. However, existing systems still suffer from problems such as insufficient compatibility of composite components, inadequate dispersion of plant phenols in the aqueous phase, unstable release of active ingredients from the wipe substrate, and insufficient integration between hydrophilic treatment and the disinfectant system. Therefore, it is necessary to develop a wipe disinfectant solution and disinfectant wipes that combine an organic acid buffer system, arginine fatty acid anions and cations, plant phenol maltodextrin microcapsules, and hydrophilic nonwoven fabric to improve formulation stability, wiping spreadability, active ingredient release stability, and actual cleaning and disinfection effects. Summary of the Invention

[0005] To address the shortcomings of existing technologies, the present invention aims to provide a disinfectant wipe solution, its preparation method, and disinfectant wipes.

[0006] A first aspect of the present invention provides a wet wipe disinfectant solution, comprising the following components in parts by weight: 0.8-2.5 parts L-lactic acid, 0.2-1.2 parts citric acid, 0.1-0.8 parts sodium lactate, 0.2-0.9 parts arginine fatty acid anions and cations, 0.05-0.35 parts plant phenolic polysaccharide composite wall material microcapsules, 2-8 parts ethanol, 1-4.5 parts 1,3-propanediol, 0.5-2.5 parts glycerol, 0.1-0.6 parts decyl glucoside, 0.02-0.12 parts disodium ethylenediaminetetraacetate, 0.05-0.25 parts sodium benzoate, and 80-95 parts deionized water.

[0007] According to a preferred embodiment of the present invention, the preparation steps of the arginine fatty acid anion and cation salts include: A1. By weight, add 8-12 parts of L-arginine to 35-55 parts of deionized water, stir at 35-45℃, add 60-90 parts of ethanol to obtain an arginine dispersion; add 8-13 parts of lauric acid, 2-5 parts of decanoic acid and 1-4 parts of octanoic acid to 25-45 parts of ethanol, stir at 50-65℃ to obtain a mixed fatty acid solution. A2. Add the mixed fatty acid solution to the arginine dispersion and react at 55-70℃ to obtain the reaction solution; concentrate, filter, dry and pulverize the reaction solution.

[0008] In this invention, the preparation of arginine fatty acid cations and anions mainly involves acid-base neutralization and salt formation, as well as ion association. It does not involve amidation, esterification, or covalent grafting reactions and does not require condensing agents or catalysts. L-arginine is dissolved in deionized water by stirring to form an aqueous solution. Ethanol is then added to create a system that combines both aqueous and ethanol dispersion environments, resulting in an arginine dispersion. Lauric acid, decanoic acid, and octanoic acid are dissolved in ethanol by stirring to obtain a mixed fatty acid solution dispersed in molecular form. When the mixed fatty acid solution is added to the arginine dispersion, the two liquid phases mix and come into contact under temperature. The guanidinium and amino groups in the L-arginine molecule act as strong basic sites, abstracting protons from the carboxyl groups of lauric acid, decanoic acid, and octanoic acid molecules. The carboxyl groups lose protons to form carboxylate anions, while the guanidinium and amino groups combine with protons to form cations. These cations immediately associate with each other through electrostatic attraction, generating an ion-associated compound composed of the arginine cation and the anions of lauric acid, decanoic acid, and octanoic acid. The proton transfer described above is driven by the high basicity of the arginine guanidino group, rather than the spontaneous dissociation of lauric acid, decanoic acid, and octanoic acid in aqueous ethanol solution. The different carbon chain lengths of lauric acid, decanoic acid, and octanoic acid result in different hydrophobic segment distributions in the resulting ion-associates; the arginine cation moiety provides the hydrophilic end and positively charged binding site, while the lauric acid, decanoic acid, and octanoic acid anions provide the hydrophobic segments. The reaction solution is concentrated to remove ethanol and deionized water, filtered to remove undissolved or unassociated insoluble matter, and then dried and pulverized to obtain arginine fatty acid cation and anion salts.

[0009] According to a preferred embodiment of the present invention, the reaction time at 55-70°C is 2-4 hours.

[0010] According to a preferred embodiment of the present invention, the preparation steps of the plant phenolic polysaccharide composite wall material microcapsules include: B1. By weight, mix 5-8 parts of thymol, 2-5 parts of carvacrol, 0.3-1 parts of tocopherol and 15-25 parts of ethanol, and stir at 35-45℃ to obtain a thymol-carvacrol core material solution; mix 18-28 parts of maltodextrin, 8-16 parts of gum arabic, 3-8 parts of β-cyclodextrin, 0.5-1.5 parts of sodium alginate, 0.8-2 parts of sucrose fatty acid ester and 120-180 parts of deionized water, and stir at 45-55℃ to obtain a wall material solution; B2. Add the thymol and carvacrol core material liquid to the wall material liquid and emulsify at 45-55℃ to obtain an emulsion dispersion; filter, spray dry and sieve the emulsion dispersion.

[0011] In this invention, the preparation of plant phenolic polysaccharide composite wall microcapsules mainly involves core material dissolution, emulsification dispersion, wall material encapsulation, and drying molding. Thymol, carvacrol, and tocopherol are all hydrophobic or lipophilic components. After being mixed with ethanol, they are dissolved and dispersed to obtain a thymol-carvacrol core material solution. Thymol and carvacrol form the thymol-carvacrol core material solution, while tocopherol, as a lipophilic protective component, is dispersed along with the core material phase. Simultaneously, tocopherol provides antioxidant protection to the phenolic hydroxyl groups in thymol and carvacrol, reducing oxidative loss of the core material during preparation and storage. Maltodextrin, gum arabic, β-cyclodextrin, sodium alginate, sucrose fatty acid ester, and deionized water were mixed. Maltodextrin formed a water-soluble wall material framework, gum arabic improved emulsification dispersion stability and film-forming properties, β-cyclodextrin, with its internal hydrophobic cavities, encapsulated some thymol and carvacrol, and sodium alginate, as a linear anionic polysaccharide molecular chain, spread out in the aqueous phase, synergistically stabilizing the aqueous interface and increasing the system viscosity with gum arabic. Sucrose fatty acid ester reduced the interfacial tension between the core material liquid and the wall material liquid, resulting in the wall material liquid. The thymol and carvacrol core material liquid was added to the wall material liquid for emulsification. The core phase was sheared and dispersed into fine droplets. Gum arabic and sodium alginate molecular chains adsorbed onto the outside of the droplets and formed an anionic polysaccharide protective layer in the interfacial region, inhibiting droplet aggregation and migration. Maltodextrin and β-cyclodextrin were distributed on the outside of the droplets and in the interfacial region, participating in the formation of the encapsulation structure, resulting in an emulsion dispersion. The emulsion dispersion was filtered to remove coarse particles and inhomogeneities, and then spray-dried to remove deionized water and ethanol. Maltodextrin, gum arabic, β-cyclodextrin, and sodium alginate intertwined during the drying process to form a semi-interpenetrating network membrane, which then solidified and coated the core material. Sodium alginate, as an anionic polysaccharide component in the membrane, had its carboxyl groups in a protonated state in the subsequent acidic wet wipe disinfectant system, which reduced the water solubility and swelling rate of the membrane and improved the long-term structural stability of the microcapsules in the aqueous system. After sieving, the plant phenolic polysaccharide composite wall material microcapsules were obtained.

[0012] According to a preferred embodiment of the present invention, the emulsification time at 45-55°C is 30-60 min.

[0013] A second aspect of the present invention provides a method for preparing the aforementioned wet wipe disinfectant solution, comprising the following steps: Disodium ethylenediaminetetraacetate, sodium lactate, and sodium benzoate were added sequentially to deionized water and stirred at 20-30°C. L-lactic acid and citric acid were then added to obtain an organic acid buffer solution. Ethanol, 1,3-propanediol, glycerol, and decyl glucoside were mixed to obtain a surface spreading aid solution. The surface spreading aid solution was added to the organic acid buffer solution and stirred at 20-35°C. Arginine fatty acid anions and cations and plant phenolic polysaccharide composite wall material microcapsules were added sequentially, and the mixture was filtered.

[0014] A third aspect of the present invention provides a disinfecting wipe, comprising a hydrophilic treated nonwoven fabric substrate and a wipe disinfecting solution loaded on the hydrophilic treated nonwoven fabric substrate; The preparation steps of the hydrophilic nonwoven fabric substrate include: mixing decyl glucoside, sodium lactate and deionized water, stirring at 20-35℃ to obtain a hydrophilic treatment solution; immersing the spunlace nonwoven fabric in the hydrophilic treatment solution, treating it at 20-35℃, taking it out and drying it.

[0015] According to a preferred embodiment of the present invention, the amounts of decyl glucoside, sodium lactate, deionized water, and spunlace nonwoven fabric, by weight, are 0.1-0.6 parts, 0.1-0.8 parts, 80-120 parts, and 80-120 parts, respectively.

[0016] According to a preferred embodiment of the present invention, the method for preparing the disinfectant wipes includes: S1. The hydrophilic nonwoven fabric substrate is placed under -0.05 to -0.08 MPa and immersed in a wet wipe disinfectant solution to obtain the impregnated nonwoven fabric. S2. Roll the impregnated nonwoven fabric, cut and fold it, and then package it in a sealed bag.

[0017] In this invention, the preparation of the disinfectant wipe solution mainly involves aqueous phase dissolution, buffer system formation, solubilizing and spreading system formation, and solid material dispersion. Disodium EDTA, sodium lactate, and sodium benzoate are sequentially added to deionized water. Disodium EDTA complexes metal ions in the aqueous phase, reducing the impact of metal ions on system stability. Sodium lactate, together with subsequently added L-lactic acid, forms the buffer base. Sodium benzoate acts as an antiseptic in the acidic system. After adding L-lactic acid and citric acid, the acidity of the system is adjusted by L-lactic acid, citric acid, and sodium lactate, resulting in an organic acid buffer solution. Ethanol, 1,3-propanediol, glycerol, and decyl glucoside are pre-mixed. Ethanol improves the dispersion of hydrophobic components in the aqueous phase, 1,3-propanediol and glycerol provide moisturizing and retaining capabilities, and decyl glucoside reduces the surface tension of the liquid and improves the wetting of the hydrophilic nonwoven fabric substrate, resulting in a surface spreading aid solution. The surface spreading aid solution is added to an organic acid buffer solution and mixed to form a homogeneous solution system. Then, arginine fatty acid anion and cation salts and plant phenolic polysaccharide composite wall material microcapsules are added sequentially to disperse the ion-pairing compounds and microcapsule particles in the system. After filtration to remove undispersed particles, the disinfectant wipe solution is obtained. The hydrophilic treated nonwoven fabric substrate is made by treating decyl glucoside, sodium lactate, deionized water, and spunlace nonwoven fabric. After immersion, rolling, cutting, folding, and sealing in bags, the disinfectant wipe solution is loaded onto the hydrophilic treated nonwoven fabric substrate to obtain disinfectant wipes.

[0018] According to a preferred embodiment of the present invention, the immersion temperature is 20-35°C.

[0019] Compared with the prior art, the present invention has the following beneficial effects: (1) The disinfectant wipes of this invention use L-lactic acid, citric acid, and sodium lactate in combination, and add disodium ethylenediaminetetraacetate and sodium benzoate to make the disinfectant wipes have a relatively stable liquid state under acidic conditions. L-lactic acid and citric acid provide an acidic environment, sodium lactate buffers the acidity changes of the disinfectant wipes, disodium ethylenediaminetetraacetate complexes deionized water and metal ions that may be introduced from the raw materials, reducing the impact of metal ions on the appearance and stability of the disinfectant wipes, and sodium benzoate plays a preservative role under acidic conditions. After the above components are combined, the risk of turbidity, precipitation, and stratification of the disinfectant wipes during storage can be reduced, and the disinfectant wipes can maintain a relatively stable liquid state when sealed in a bag.

[0020] (2) Arginine fatty acid anions and cations are prepared from L-arginine, lauric acid, capric acid, and octanoic acid. They contain hydrophilic ionic moieties and hydrophobic fatty acid segments, which can improve the distribution of liquid on hydrophilically treated nonwoven fabric substrates and the surfaces being wiped in wet wipe disinfectant solutions. Lauric acid, capric acid, and octanoic acid have different segment lengths, resulting in different hydrophobic segment distributions of arginine fatty acid anions and cations in wet wipe disinfectant solutions. Decyl glucoside can reduce the surface tension of wet wipe disinfectant solutions. When used in conjunction with arginine fatty acid anions and cations, it helps improve the wetting, spreading, and release states of wet wipe disinfectant solutions, reducing the problem of uneven liquid content during wiping with disinfectant wipes.

[0021] (3) The plant phenolic polysaccharide composite wall material microcapsules are prepared from thymol, carvacrol, tocopherol, maltodextrin, gum arabic, β-cyclodextrin, sodium alginate and sucrose fatty acid esters. Maltodextrin, gum arabic and β-cyclodextrin encapsulate and disperse thymol, carvacrol and tocopherol, which can reduce the precipitation and volatilization of thymol and carvacrol in the wet wipe disinfectant. The combined use of ethanol, 1,3-propanediol and glycerin can improve the dispersion of hydrophobic components in the wet wipe disinfectant and improve the moisture retention of the disinfectant wipes. After the hydrophilic nonwoven fabric substrate is treated with decyl glucoside, sodium lactate and deionized water, the adsorption and release of the wet wipe disinfectant are more uniform. The resulting disinfectant wipes have the technical effects of uniform liquid distribution, good wiping spreadability, good storage stability and mild odor. Detailed Implementation

[0022] To facilitate understanding of the present invention, the following embodiments are provided. Those skilled in the art should understand that these embodiments are merely illustrative and should not be construed as limiting the scope of the invention.

[0023] Example 1

[0024] This embodiment provides a method for preparing disinfectant wipes, the steps of which include: S1. The hydrophilic nonwoven fabric substrate is placed at -0.065MPa and immersed in a wet wipe disinfectant solution at an immersion temperature of 27.5℃ for 20 minutes to obtain the impregnated nonwoven fabric. S2. Roll the soaked nonwoven fabric to control the liquid content to 320%, then cut and fold it, and package it in a sealed bag. Equilibrate it at 25°C for 12 hours to obtain disinfectant wipes.

[0025] Preparation steps for wet wipe disinfectant solution: 0.07 g disodium ethylenediaminetetraacetate, 0.45 g sodium lactate, and 0.15 g sodium benzoate were added sequentially to 87.5 g of deionized water and stirred at 300 rpm for 30 min at 25 °C until dissolved. 1.65 g L-lactic acid and 0.7 g citric acid were added, and stirring continued for 20 min to obtain an organic acid buffer solution. 5 g ethanol, 2.75 g 1,3-propanediol, 1.5 g glycerol, and 0.35 g decyl glucoside were mixed and stirred at 300 rpm for 20 min at 25 °C to obtain a surface spreading aid solution. This surface spreading aid solution was added to the organic acid buffer solution and stirred at 300 rpm for 30 min at 27.5 °C. 0.55 g arginine fatty acid anions and cations and 0.2 g plant phenolic polysaccharide composite wall material microcapsules were added sequentially, and stirring continued for 45 min. The solution was then filtered through a 5 μm filter membrane to obtain a wet wipe disinfectant solution.

[0026] Preparation steps of hydrophilic treated nonwoven fabric substrate: Mix 0.35g decyl glucoside, 0.45g sodium lactate and 100g deionized water, and stir at 300r / min for 30min at 27.5℃ to obtain a hydrophilic treatment solution; immerse 100g spunlace nonwoven fabric in the hydrophilic treatment solution, treat at 27.5℃ for 30min, remove and dry at 45℃ for 60min to obtain a hydrophilic treated nonwoven fabric substrate.

[0027] Preparation steps of arginine fatty acid anions and cations: A1. Add 10g of L-arginine to 45g of deionized water and stir at 300r / min for 30min at 40℃ to uniformly disperse the L-arginine. Add 75g of ethanol and continue stirring at 300r / min for 20min to obtain an arginine dispersion. Add 10.5g of lauric acid, 3.5g of decanoic acid and 2.5g of octanoic acid to 35g of ethanol and stir at 300r / min for 40min at 57.5℃ to uniformly disperse the lauric acid, decanoic acid and octanoic acid to obtain a mixed fatty acid solution. A2. The mixed fatty acid solution was added to the arginine dispersion within 30 min, and the reaction was carried out at 62.5℃ and 300 r / min for 3 h to obtain the reaction solution. The reaction solution was concentrated at 55℃ and -0.08 MPa until there was no obvious ethanol odor. The solution was filtered through a 5 μm filter membrane, and the filtrate was vacuum dried at 55℃ for 8 h. The resulting solid was pulverized and passed through a 180 μm sieve to obtain arginine fatty acid anions and cations.

[0028] Preparation steps of plant phenolic polysaccharide composite wall material microcapsules: B1. Mix 6.5g thymol, 3.5g carvacrol, 0.65g tocopherol and 20g ethanol, and stir at 300r / min for 30min at 40℃ to obtain thymol-carvacrol core material solution; mix 23g maltodextrin, 12g gum arabic, 5.5g β-cyclodextrin, 1.0g sodium alginate, 1.4g sucrose fatty acid ester and 150g deionized water, and stir at 400r / min for 60min at 50℃ to obtain wall material solution; B2. The thymol and carvacrol core material liquid was added to the wall material liquid within 20 min, and emulsified at 8000 r / min for 45 min at 50℃ to obtain an emulsion dispersion. The emulsion dispersion was filtered through a 100 μm sieve and then spray-dried. The inlet air temperature of the spray drying was 150℃ and the outlet air temperature was 80℃. The resulting powder was sieved through a 180 μm sieve to obtain plant phenolic polysaccharide composite wall material microcapsules.

[0029] Example 2

[0030] This embodiment provides a method for preparing disinfectant wipes, the steps of which include: S1. The hydrophilic nonwoven fabric substrate is placed under -0.05MPa and immersed in wet wipe disinfectant solution at an immersion temperature of 20℃ for 15 minutes to obtain the impregnated nonwoven fabric. S2. Roll the soaked nonwoven fabric to control the liquid content to 280%, then cut and fold it, and package it in a sealed bag. Equilibrate it at 25°C for 12 hours to obtain disinfectant wipes.

[0031] Preparation steps for wet wipe disinfectant solution: 0.02 g disodium ethylenediaminetetraacetate, 0.1 g sodium lactate, and 0.05 g sodium benzoate were added sequentially to 80 g of deionized water and stirred at 250 rpm for 25 min at 20 °C until dissolved. 0.8 g L-lactic acid and 0.2 g citric acid were added, and stirring continued for 15 min to obtain an organic acid buffer solution. 2 g ethanol, 1 g 1,3-propanediol, 0.5 g glycerol, and 0.1 g decyl glucoside were mixed and stirred at 250 rpm for 15 min at 20 °C to obtain a surface spreading aid solution. This surface spreading aid solution was added to the organic acid buffer solution and stirred at 250 rpm for 25 min at 20 °C. 0.2 g arginine fatty acid anions and cations and 0.05 g plant phenolic polysaccharide composite wall material microcapsules were added sequentially, and stirring continued for 35 min. The solution was then filtered through a 5 μm filter membrane to obtain a wet wipe disinfectant solution.

[0032] Preparation steps of hydrophilic treated nonwoven fabric substrate: Mix 0.1g decyl glucoside, 0.1g sodium lactate and 80g deionized water, and stir at 250r / min for 25min at 20℃ to obtain a hydrophilic treatment solution; immerse 80g spunlace nonwoven fabric in the hydrophilic treatment solution, treat at 20℃ for 25min, remove and dry at 40℃ for 60min to obtain a hydrophilic treated nonwoven fabric substrate.

[0033] Preparation steps of arginine fatty acid anions and cations: A1. Add 8g of L-arginine to 35g of deionized water and stir at 250r / min for 25min at 35℃ to uniformly disperse the L-arginine. Add 60g of ethanol and continue stirring at 250r / min for 15min to obtain an arginine dispersion. Add 8g of lauric acid, 2g of decanoic acid and 1g of octanoic acid to 25g of ethanol and stir at 250r / min for 35min at 50℃ to uniformly disperse the lauric acid, decanoic acid and octanoic acid to obtain a mixed fatty acid solution. A2. The mixed fatty acid solution was added to the arginine dispersion within 25 min, and the reaction was carried out at 55℃ and 250 r / min for 2 h to obtain the reaction solution. The reaction solution was concentrated at 50℃ and -0.08 MPa until there was no obvious ethanol odor. The solution was filtered through a 5 μm filter membrane, and the filtrate was vacuum dried at 50℃ for 8 h. The resulting solid was pulverized and passed through a 180 μm sieve to obtain arginine fatty acid anions and cations.

[0034] Preparation steps of plant phenolic polysaccharide composite wall material microcapsules: B1. Mix 5g thymol, 2g carvacrol, 0.3g tocopherol and 15g ethanol, and stir at 250r / min for 25min at 35℃ to obtain thymol-carvacrol core material solution; mix 18g maltodextrin, 8g gum arabic, 3g β-cyclodextrin, 0.5g sodium alginate, 0.8g sucrose fatty acid ester and 120g deionized water, and stir at 350r / min for 50min at 45℃ to obtain wall material solution; B2. The thymol and carvacrol core material liquid was added to the wall material liquid within 15 min, and emulsified at 7000 r / min at 45℃ for 30 min to obtain an emulsion dispersion. The emulsion dispersion was filtered through a 100 μm sieve and then spray-dried. The inlet air temperature of the spray drying was 145℃ and the outlet air temperature was 75℃. The resulting powder was sieved through a 180 μm sieve to obtain plant phenolic polysaccharide composite wall material microcapsules.

[0035] Example 3

[0036] This embodiment provides a method for preparing disinfectant wipes, the steps of which include: S1. The hydrophilic nonwoven fabric substrate is placed at -0.08MPa and immersed in a wet wipe disinfectant solution at a temperature of 35℃ for 25 minutes to obtain the impregnated nonwoven fabric. S2. Roll the soaked nonwoven fabric to control the liquid retention rate to 360%, then cut and fold it, and package it in a sealed bag. Equilibrate it at 25°C for 12 hours to obtain disinfectant wipes.

[0037] Preparation steps for wet wipe disinfectant solution: 0.12 g of disodium ethylenediaminetetraacetate, 0.8 g of sodium lactate, and 0.25 g of sodium benzoate were added sequentially to 95 g of deionized water and stirred at 350 rpm for 35 min at 30 °C until dissolved. 2.5 g of L-lactic acid and 1.2 g of citric acid were added, and stirring continued for 25 min to obtain an organic acid buffer solution. 8 g of ethanol, 4.5 g of 1,3-propanediol, 2.5 g of glycerol, and 0.6 g of decyl glucoside were mixed and stirred at 350 rpm for 25 min at 30 °C to obtain a surface spreading aid solution. This surface spreading aid solution was added to the organic acid buffer solution and stirred at 350 rpm for 35 min at 35 °C. 0.9 g of arginine fatty acid anions and cations and 0.35 g of plant phenolic polysaccharide composite wall material microcapsules were added sequentially, and stirring continued for 55 min. The solution was then filtered through a 5 μm filter membrane to obtain a wet wipe disinfectant solution.

[0038] Preparation steps of hydrophilic treated nonwoven fabric substrate: Mix 0.6g decyl glucoside, 0.8g sodium lactate and 120g deionized water, and stir at 350r / min for 35min at 35℃ to obtain a hydrophilic treatment solution; immerse 120g spunlace nonwoven fabric in the hydrophilic treatment solution, treat at 35℃ for 35min, remove and dry at 50℃ for 60min to obtain a hydrophilic treated nonwoven fabric substrate.

[0039] Preparation steps of arginine fatty acid anions and cations: A1. Add 12g of L-arginine to 55g of deionized water and stir at 350r / min for 35min at 45℃ to uniformly disperse the L-arginine. Add 90g of ethanol and continue stirring at 350r / min for 25min to obtain an arginine dispersion. Add 13g of lauric acid, 5g of decanoic acid and 4g of octanoic acid to 45g of ethanol and stir at 350r / min for 45min at 65℃ to uniformly disperse the lauric acid, decanoic acid and octanoic acid to obtain a mixed fatty acid solution. A2. The mixed fatty acid solution was added to the arginine dispersion within 35 min, and the reaction was carried out at 70℃ and 350 r / min for 4 h to obtain the reaction solution. The reaction solution was concentrated at 60℃ and -0.08 MPa until there was no obvious ethanol odor. The solution was filtered through a 5 μm filter membrane, and the filtrate was vacuum dried at 60℃ for 8 h. The resulting solid was pulverized and passed through a 180 μm sieve to obtain arginine fatty acid anions and cations.

[0040] Preparation steps of plant phenolic polysaccharide composite wall material microcapsules: B1. Mix 8g thymol, 5g carvacrol, 1g tocopherol and 25g ethanol, and stir at 350r / min for 35min at 45℃ to obtain thymol-carvacrol core material solution; mix 28g maltodextrin, 16g gum arabic, 8g β-cyclodextrin, 1.5g sodium alginate, 2g sucrose fatty acid ester and 180g deionized water, and stir at 450r / min for 70min at 55℃ to obtain wall material solution; B2. The thymol and carvacrol core material liquid was added to the wall material liquid within 25 min, and emulsified at 55℃ and 9000 r / min for 60 min to obtain an emulsion dispersion. The emulsion dispersion was filtered through a 100 μm sieve and then spray-dried. The inlet air temperature of the spray drying was 155℃ and the outlet air temperature was 85℃. The resulting powder was sieved through a 180 μm sieve to obtain plant phenolic polysaccharide composite wall material microcapsules.

[0041] Comparative Example 1 The difference between this comparative example and Example 1 is that arginine fatty acid anions and cations are not prepared and added, and the amount of deionized water in the wet wipe disinfectant solution is adjusted to 88.05g. The rest is the same as in Example 1.

[0042] Comparative Example 2 The difference between this comparative example and Example 1 is that plant phenolic polysaccharide composite wall material microcapsules are not prepared and are not added, and the amount of deionized water in the wet wipe disinfectant solution is adjusted to 87.7g. The rest is the same as in Example 1.

[0043] Comparative Example 3 The difference between this comparative example and Example 1 is that arginine fatty acid anion and cation salts and plant phenolic polysaccharide composite wall material microcapsules are not prepared and are not added. The amount of deionized water in the wet wipe disinfectant solution is adjusted to 88.25g. The rest is the same as in Example 1.

[0044] The performance of the disinfectant wipes obtained in Examples 1-3 and Comparative Examples 1-3 was tested.

[0045] Disinfecting wipes prepared in Examples 1, 2, 3, 1, 2, and 3 were used as test samples. All samples were sealed and equilibrated for 24 hours at 25°C and 50% relative humidity before testing.

[0046] The kill rates of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans were determined using quantitative kill tests. Before the tests, each test strain was revived and prepared into bacterial suspensions, with the initial colony count of the suspensions controlled at 2.5 × 10⁻⁶. 6 CFU / mL, samples of disinfectant wipes from the same batch were taken, and the wipe extract was obtained by aseptic squeezing as the reaction solution. 1 mL of bacterial suspension was added to 9 mL of the reaction solution, and after thorough mixing, it was reacted at 20℃ for 5 min. After the reaction time was reached, a neutralizing agent that had been proven effective in preliminary tests and was non-toxic to the test bacteria was immediately added to terminate the reaction. After mixing, a 10-fold serial dilution was performed, and the appropriate dilution was used for inoculation and culture. Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were cultured at 36℃±1℃ for 48 h, and Candida albicans was cultured at 28℃±1℃ for 72 h. After culture, the number of colonies was counted. At the same time, a positive control group, a neutralizing agent control group, a negative control group, and a culture medium control group were set up. The test groups and control groups were tested in parallel for 3 times. The kill rate was calculated as (average number of colonies in the positive control group - average number of colonies in the test group) / average number of colonies in the positive control group × 100%.

[0047] For the wiping release rate test, take a single disinfectant wipe after sealing and balancing. First, weigh the wipe before wiping. Then, lay the wipe flat on a clean glass plate and wipe it 10 times along a 100mm wiping distance with a 500g pressure pad. The wiping speed is controlled at 100mm / s. Immediately after wiping, weigh the wipe after wiping. Take another dry hydrophilic non-woven fabric substrate of the same specification and weigh the dry cloth. Calculate the wiping release rate as follows: wiping release rate = (wet wipe before wiping - wet wipe after wiping) / (wet wipe before wiping - dry cloth) × 100%. Test 10 wipes in each group and take the average value.

[0048] For the 24-hour liquid retention rate test after opening, take 10 sealed disinfectant wipes from the same batch, weigh the total weight before opening, open the sealed bag, and place them at 25℃, 50% relative humidity, and no direct airflow for 24 hours. Weigh the total weight after opening again, and separately weigh the corresponding dry hydrophilic nonwoven fabric substrate. Calculate the 24-hour liquid retention rate as follows: (Total weight after opening - Dry fabric weight) / (Total weight before opening - Dry fabric weight) × 100%.

[0049] In all the above tests, microbial counts were based on countable plates, and the results were expressed as the average of parallel samples.

[0050] The performance test data above are shown in Table 1.

[0051] Table 1: Performance Test Results

[0052] The test results in Table 1 above clearly show that Example 1, by simultaneously adding arginine fatty acid anionic and cationic salts and plant phenolic polysaccharide composite wall material microcapsules, solves the problems of insufficient bactericidal ability, insufficient wiping release, and insufficient liquid retention after opening of existing wet wipe disinfectant solutions, compared with Comparative Examples 1-3 which lack one or both arginine fatty acid anionic and cationic salts and plant phenolic polysaccharide composite wall material microcapsules.

[0053] In Example 1, the kill rates of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans were 99.99%, 99.98%, 99.95%, and 99.82%, respectively, all significantly higher than those of Comparative Example 3 (96.84%, 95.72%, 94.63%, and 92.56%). This indicates that relying solely on the basic system composed of L-lactic acid, citric acid, sodium lactate, ethanol, 1,3-propanediol, glycerol, decyl glucoside, disodium EDTA, and sodium benzoate is insufficient to achieve a sufficiently broad-spectrum killing effect.

[0054] Compared with Comparative Example 1, which did not contain arginine fatty acid anions and cations, the wiping release rate of Example 1 increased from 70.5% to 83.6%, the Escherichia coli kill rate increased from 99.21% to 99.99%, the Staphylococcus aureus kill rate increased from 98.94% to 99.98%, the Pseudomonas aeruginosa kill rate increased from 98.62% to 99.95%, and the Candida albicans kill rate increased from 98.18% to 99.82%. This indicates that arginine fatty acid anions and cations can improve the wetting and release state of the disinfectant wipes in the hydrophilic nonwoven fabric substrate, allowing the disinfectant wipes to be released more fully from the hydrophilic nonwoven fabric substrate during wiping, thereby improving the contact efficiency between the disinfectant wipes and the wiped surface and microorganisms.

[0055] Compared with Comparative Example 2, which did not contain thymol and carvacrol maltodextrin microcapsules, the kill rate of Escherichia coli in Example 1 increased from 98.76% to 99.99%, the kill rate of Staphylococcus aureus increased from 98.31% to 99.98%, the kill rate of Pseudomonas aeruginosa increased from 97.85% to 99.95%, and the kill rate of Candida albicans increased from 96.72% to 99.82%. This indicates that the thymol and carvacrol maltodextrin microcapsules can improve the dispersion and utilization of thymol, carvacrol, and tocopherol in the disinfectant wipes, making the hydrophobic plant phenolic components more uniform in the aqueous system. The dispersion state of the disinfectant wipes improves their effectiveness against bacteria and fungi. Example 1 showed a 92.8% liquid retention rate after 24 hours of opening, higher than Comparative Example 2's 90.1%. This indicates that although the thymol, carvacrol, and maltodextrin microcapsules are not the main moisturizing component, the hydrophilic composite wall material formed by maltodextrin, gum arabic, β-cyclodextrin, and sucrose fatty acid esters can improve the uniformity of the disinfectant wipes' distribution and the retention state between fibers in the hydrophilically treated nonwoven fabric substrate. Combined with 1,3-propanediol, glycerol, and decyl glucoside, these components further enhance the liquid retention capacity of the wipes after opening.

[0056] The wiping release rate of Example 1 was 83.6%, significantly higher than that of Comparative Example 1 (70.5%) and Comparative Example 3 (68.7%), indicating that the arginine, laurate, caprylic acid, and octanoic acid anions and cations mainly improve the wetting and release performance of the wet wipe disinfectant. The liquid retention rate of Example 1 after 24 hours of opening was 92.8%, higher than that of Comparative Example 2 (90.1%) and Comparative Example 3 (88.9%), indicating that the thymol, carvacrol, and maltodextrin microcapsules mainly improve the dispersion and utilization of thymol, carvacrol, and tocopherol, and also play an auxiliary role in the uniform retention of the wet wipe disinfectant through the hydrophilic composite wall material. Therefore, the arginine, laurate, caprylic acid, and octanoic acid anions and cations primarily address the problem of insufficient wiping release, while the thymol, carvacrol, and maltodextrin microcapsules primarily address the problem of insufficient dispersion and utilization of hydrophobic plant phenolic components. When combined with 1,3-propanediol, glycerol, decyl glucoside, and a hydrophilic-treated nonwoven fabric substrate, the wet wipe disinfectant exhibits both good release properties and stable liquid retention after opening.

[0057] Therefore, Example 1, compared with Comparative Examples 1-3, demonstrates that the microcapsules of arginine fatty acid anionic and cationic salts and plant phenolic polysaccharides composite wall material have a synergistic effect in the system of the present invention, and can jointly solve the technical problems of insufficient release of effective ingredients, insufficient broad-spectrum killing ability, and decreased liquid retention after opening of existing disinfectant wipes.

Claims

1. A disinfectant wipe, characterized in that, It includes the following components in parts by weight: 0.8-2.5 parts L-lactic acid, 0.2-1.2 parts citric acid, 0.1-0.8 parts sodium lactate, 0.2-0.9 parts arginine fatty acid anions and cations, 0.05-0.35 parts plant phenolic polysaccharide composite wall material microcapsules, 2-8 parts ethanol, 1-4.5 parts 1,3-propanediol, 0.5-2.5 parts glycerol, 0.1-0.6 parts decyl glucoside, 0.02-0.12 parts disodium ethylenediaminetetraacetate, 0.05-0.25 parts sodium benzoate, and 80-95 parts deionized water.

2. The disinfectant wipes according to claim 1, characterized in that, The preparation steps of the arginine fatty acid anion and cation salts include: A1. By weight, add 8-12 parts of L-arginine to 35-55 parts of deionized water, stir at 35-45℃, add 60-90 parts of ethanol to obtain an arginine dispersion; add 8-13 parts of lauric acid, 2-5 parts of decanoic acid and 1-4 parts of octanoic acid to 25-45 parts of ethanol, stir at 50-65℃ to obtain a mixed fatty acid solution. A2. Add the mixed fatty acid solution to the arginine dispersion and react at 55-70℃ to obtain the reaction solution; concentrate, filter, dry and pulverize the reaction solution.

3. The disinfectant wipes according to claim 2, characterized in that, The reaction time is 2-4 hours at 55-70℃.

4. The disinfectant wipes according to claim 1, characterized in that, The preparation steps of the plant phenolic polysaccharide composite wall material microcapsules include: B1. By weight, mix 5-8 parts of thymol, 2-5 parts of carvacrol, 0.3-1 parts of tocopherol and 15-25 parts of ethanol, and stir at 35-45℃ to obtain a thymol-carvacrol core material solution; mix 18-28 parts of maltodextrin, 8-16 parts of gum arabic, 3-8 parts of β-cyclodextrin, 0.5-1.5 parts of sodium alginate, 0.8-2 parts of sucrose fatty acid ester and 120-180 parts of deionized water, and stir at 45-55℃ to obtain a wall material solution; B2. Add the thymol and carvacrol core material liquid to the wall material liquid and emulsify at 45-55℃ to obtain an emulsion dispersion; filter, spray dry and sieve the emulsion dispersion.

5. The disinfectant wipes according to claim 4, characterized in that, The emulsification time is 30-60 minutes at 45-55℃.

6. A method for preparing a disinfectant wipe solution according to any one of claims 1-5, characterized in that, Includes the following steps: Disodium ethylenediaminetetraacetate, sodium lactate, and sodium benzoate were added sequentially to deionized water and stirred at 20-30°C. L-lactic acid and citric acid were then added to obtain an organic acid buffer solution. Ethanol, 1,3-propanediol, glycerol, and decyl glucoside were mixed to obtain a surface spreading aid solution. The surface spreading aid solution was added to the organic acid buffer solution and stirred at 20-35°C. Arginine fatty acid anions and cations and plant phenolic polysaccharide composite wall material microcapsules were added sequentially, and the mixture was filtered.

7. A disinfectant wipe, characterized in that, The wipes include a hydrophilically treated nonwoven fabric substrate and a wet wipe disinfectant solution loaded on the hydrophilically treated nonwoven fabric substrate, wherein the wet wipe disinfectant solution is the wet wipe disinfectant solution according to any one of claims 1-5; The preparation steps of the hydrophilic nonwoven fabric substrate include: mixing decyl glucoside, sodium lactate and deionized water, stirring at 20-35℃ to obtain a hydrophilic treatment solution; immersing the spunlace nonwoven fabric in the hydrophilic treatment solution, treating it at 20-35℃, taking it out and drying it.

8. The disinfectant wipes according to claim 7, characterized in that, By weight, the amounts of decyl glucoside, sodium lactate, deionized water, and spunlace nonwoven fabric are 0.1-0.6 parts, 0.1-0.8 parts, 80-120 parts, and 80-120 parts, respectively.

9. The disinfectant wipes according to claim 7, characterized in that, The method for preparing the disinfectant wipes includes: S1. The hydrophilic nonwoven fabric substrate is placed under -0.05 to -0.08 MPa and immersed in a wet wipe disinfectant solution to obtain the impregnated nonwoven fabric. S2. Roll the impregnated nonwoven fabric, cut and fold it, and then package it in a sealed bag.

10. The disinfectant wipes according to claim 9, characterized in that, The immersion temperature is 20-35℃.

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