A scalp anti-inflammatory repair, hair follicle energy-empowering, and hair root strengthening complex composition and applications

Abstract

The application provides a scalp anti-inflammatory repair, hair follicle energy empowerment and hair root toughness compound composition and application, and relates to the hair care and hair strengthening technical field.The application takes polyaspartic acid, adenosine and eclipta extract as a core active compound system, constructs a "scalp barrier repair-hair follicle energy empowerment-hair root toughness and hair strengthening" three-layer synergistic mechanism: polyaspartic acid anti-inflammatory repair of the scalp barrier, construction of a nutrition absorption channel;adenosine targeted improvement of hair follicle ATP synthesis, improvement of microcirculation energy supply;eclipta extract nourishes hair papilla, strengthens hair root resistance.This composition can be widely applied to scalp essence, hair growth liquid, shampoo and various hair care products, can significantly improve scalp inflammation redness, improve hair follicle activity, enhance hair root toughness, reduce hair breakage and hair loss, the formula is mild and non-irritating, is suitable for sensitive scalp, the preparation process is simple and controllable, and is suitable for industrialized production.

Description

Technical Field

[0001] This invention relates to the field of cosmetic hair care and strengthening technology, specifically to scalp care and hair care and strengthening compound active compositions, and particularly to a compound composition and its application for scalp anti-inflammatory repair, hair follicle energy empowerment and hair root strengthening. Background Technology

[0002] With the influence of factors such as work-rest stress, environmental irritants, and improper hair care, sub-healthy scalp problems are becoming increasingly common: Damaged scalp barrier leads to inflammation, redness, itching, and oiliness; insufficient energy in hair follicles causes follicle atrophy and thinning hair; and fragile hair roots lead to breakage and abnormal hair loss. These three types of problems often coexist and are mutually causal, but existing scalp care products generally have the following technical shortcomings:

[0003] Single efficacy, lacking full-chain effect

[0004] Most products focus on a single effect. For example, anti-inflammatory products cannot improve hair follicle vitality, and hair growth products ignore basic scalp inflammation. Scalp inflammation will continue to damage hair follicles, and insufficient hair follicle vitality will aggravate hair root weakness. A single effect cannot solve scalp and hair problems at the root.

[0005] Single-component effects are limited and synergistic effects are poor.

[0006] Polyaspartic acid possesses excellent moisturizing, repairing, and anti-inflammatory properties, but its follicle-enhancing effect is weak; adenosine can boost follicle energy, but its scalp repair ability is limited; Eclipta prostrata, as a traditional hair-nourishing plant ingredient, has a clear effect on strengthening hair roots, but its anti-inflammatory and penetrating properties are insufficient. Current technology has not scientifically combined these three ingredients to form a synergistic system with complementary effects, resulting in a significant reduction in the overall hair care effect.

[0007] Poor activity and stability, lack of protection in the preparation process

[0008] Adenosine and plant extracts are mostly heat-sensitive ingredients. High-temperature homogenization processes can easily lead to degradation of their active ingredients, resulting in a decrease in the efficacy of the final product. At the same time, some formulas have a pH that deviates from the slightly acidic environment of the scalp, which not only irritates the scalp but also accelerates the deactivation of active ingredients.

[0009] The formula is highly irritating and has poor compatibility with sensitive scalps.

[0010] Some hair care products add alcohol, strong preservatives, and irritating penetration enhancers in pursuit of short-term results, which can easily aggravate scalp inflammation and barrier damage. Long-term use may actually exacerbate hair loss and breakage problems.

[0011] Therefore, developing a compound composition that simultaneously covers scalp anti-inflammation, hair follicle energy supply, and hair root strengthening, while being stable in activity and mild and safe, is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0012] To address the shortcomings of existing technologies, this invention provides a compound composition and its application for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. Existing scalp care products suffer from limited efficacy, restrictive effects of single ingredients, and an inability to simultaneously address the full-chain needs of scalp anti-inflammatory, hair follicle energy enhancement, and hair root strengthening. This invention solves the following problems:

[0013] 1. It solves the problem of existing products having only one function, and achieves a three-in-one effect of anti-inflammatory scalp, hair follicle empowerment and hair root strengthening, improving scalp and hair health through the whole process;

[0014] 2. To address the limitations of single-component effects, a three-layer synergistic mechanism is formed through the scientific combination of polyaspartic acid, adenosine, and Eclipta prostrata, thereby achieving a multiplied effect;

[0015] 3. To address the issue of easy degradation of active ingredients, the stability of the ingredients is ensured through a low-temperature feeding process and a weak acid system;

[0016] 4. To address the issue of formula irritation, a gentle and non-irritating excipient system has been developed, suitable for sensitive scalps;

[0017] 5. Improves the versatility of the formula, making it compatible with various hair care products, which facilitates industrial production and market application.

[0018] To achieve the above objectives, the present invention provides the following technical solution:

[0019] A compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening, wherein the active ingredients, by weight percentage, consist of 0.5%~5.0% polyaspartic acid, 0.1%~2.0% adenosine, and 0.2%~3.0% Eclipta prostrata extract, with the remainder being cosmetically acceptable excipients; the three components work synergistically to simultaneously achieve the triple effects of scalp anti-inflammatory barrier repair, hair follicle energy supply enhancement, and hair root strengthening.

[0020] Furthermore, the polyaspartic acid is sodium polyaspartate with a number average molecular weight of 3000~10000 Da; the Eclipta prostrata extract is a refined product obtained by water extraction and alcohol precipitation of the whole Eclipta prostrata herb, wherein the mass content of the active ingredient Wedelia lactone is ≥0.5%.

[0021] Further, the cosmetic excipients acceptable to the cosmetic include one or more of the following: moisturizing base (0.5%~8.0%), solubilizer (0.1%~1.0%), soothing agent (0.05%~0.5%), chelating agent (0.02%~0.1%), and mild preservative system (0.5%~2.0%).

[0022] Furthermore, the moisturizing matrix is ​​one or more of glycerin, propylene glycol, sodium hyaluronate, and panthenol; the soothing agent is one or two of dipotassium glycyrrhizate and bisabolol.

[0023] Furthermore, the pH value of the composition is adjusted to 5.5~6.5, which is weakly acidic and compatible with the physiological environment of the scalp sebum film, reducing the risk of scalp irritation.

[0024] Furthermore, a method for preparing a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening includes the following steps:

[0025] Step S1: Preparation of aqueous matrix

[0026] Add deionized water, chelating agent, and moisturizing matrix into the reaction vessel, stir and heat to 75~80℃, and continue stirring until the material is completely dissolved and homogeneously dispersed.

[0027] Step S2: Low-temperature activation feeding

[0028] Cool the system to below 45°C, then add polyaspartic acid, adenosine, Eclipta prostrata extract, soothing agent, and solubilizer in sequence, and stir at medium speed until completely dispersed and dissolved.

[0029] Step S3: Adjust the discharge value

[0030] Cool the system to room temperature, add a mild preservative system and stir well. Adjust the pH to 5.5-6.5 with citric acid, let it stand to defoam, and then filter it through a microporous filter before discharging.

[0031] Furthermore, in step S2, the temperature of the entire system for feeding adenosine and Eclipta prostrata extract does not exceed 45°C, and the stirring speed is controlled at 150~200 r / min to avoid oxidation and degradation of active ingredients caused by high temperature and high shear.

[0032] Furthermore, the cosmetic product is used to improve scalp inflammation and redness, repair the scalp barrier, increase hair follicle energy levels, enhance hair root tensile strength, and reduce hair breakage and abnormal hair loss.

[0033] Furthermore, the dosage form of the cosmetic is any one of scalp serum, hair growth serum, shampoo, conditioner, scalp massage cream, or leave-in hair spray.

[0034] Furthermore, the compound composition is added to the finished cosmetic product at a rate of 2% to 20% by mass. It is used 1 to 2 times daily and can significantly improve scalp health and hair root strength after continuous use for more than 28 days.

[0035] This invention provides a compound composition and its application for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. It has the following beneficial effects:

[0036] 1. This invention provides a compound composition and application for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. It covers scalp anti-inflammatory, hair follicle energy enhancement, and hair root strengthening, improving scalp sub-health from the root cause and solving the problem of single-effect products that only treat the symptoms and not the root cause. Moreover, the three-layer synergistic mechanism makes the overall care effect far superior to that of a single ingredient. A 28-day trial showed that the improvement rate of scalp redness, the improvement rate of hair follicle vitality, and the strengthening of hair roots were all significantly higher than those of single components.

[0037] 2. This invention provides a compound composition and its application for anti-inflammatory repair of the scalp, energy enhancement of hair follicles and strengthening of hair roots. It adopts a weak acid system and mild excipients, and is free of alcohol and strong irritants. It can be safely used on sensitive scalps and scalps with damaged barriers. The low-temperature feeding process effectively protects heat-sensitive activity, has good batch stability, and is suitable for industrial mass production.

[0038] 3. This invention provides a compound composition and its application for anti-inflammatory repair of the scalp, energy enhancement of hair follicles and strengthening of hair roots. The dosage form has wide adaptability and can be added to a variety of hair care products such as serums, shampoos and sprays to meet the care needs of different consumer scenarios. It has a wider range of applications and strong market adaptability. Attached Figure Description

[0039] Figure 1 This is a schematic diagram of the three-layer synergistic mechanism of the compound composition of the present invention;

[0040] Figure 2 This is a flowchart illustrating the preparation process of the compound composition of the present invention. Detailed Implementation

[0041] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, the accompanying drawings show only the parts relevant to the present invention, and not all of the structures.

[0042] In the description of this invention, unless otherwise explicitly specified and limited, the terms "connected," "linked," and "fixed" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0043] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0044] In the description of this embodiment, the terms "upper," "lower," "right," etc., refer to the orientation or positional relationship shown in the accompanying drawings. They are used only for ease of description and simplification of operation, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention. In addition, the terms "first" and "second" are used only for distinction in description and have no special meaning.

[0045] The technical solution of the present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0046] like Figures 1-2 As shown, this invention provides a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. By weight percentage, the active ingredients consist of 0.5%~5.0% polyaspartic acid, 0.1%~2.0% adenosine, and 0.2%~3.0% Eclipta prostrata extract, with the remainder being cosmetically acceptable excipients. The three components work synergistically to simultaneously achieve the triple effects of scalp anti-inflammatory barrier repair, hair follicle energy supply enhancement, and hair root strengthening.

[0047] This invention utilizes polyaspartic acid to repair the scalp surface barrier, adenosine to supply energy to the middle layer of hair follicles, and Eclipta prostrata to strengthen and solidify hair roots. The three work in a progressive manner from the outside to the inside, with complementary and synergistic effects.

[0048] Core active components and mechanism of action:

[0049] Polyaspartic acid (sodium polyaspartate): As the core of the first layer of scalp repair, polyaspartic acid is a natural amino acid polymer with excellent moisturizing, biocompatibility, and anti-inflammatory properties. It can penetrate the stratum corneum of the scalp, replenish intercellular lipids, and repair the damaged scalp barrier; it inhibits the release of inflammatory factors such as IL-6 and TNF-α, relieving scalp redness, itching, and oiliness; at the same time, it forms a breathable moisturizing film on the scalp surface, maintaining a hydrated environment and creating a good channel for the penetration and absorption of adenosine and Eclipta prostrata extract, reducing the continuous damage of inflammation to hair follicles. This invention uses sodium polyaspartate with a molecular weight of 3000~10000 Da, taking into account both permeability and film-forming properties.

[0050] Adenosine: As the core of the second layer of hair follicle activation, adenosine is a key precursor substance for cellular energy metabolism. It can penetrate the scalp barrier to reach the hair follicle layer, promote ATP synthesis in hair follicle cells, increase hair follicle energy levels, and activate hair matrix cell vitality. Simultaneously, it improves scalp microcirculation, increases nutrient and oxygen supply to hair follicles, delays hair follicle atrophy, and provides sufficient energy for hair growth. The healthy barrier repaired by polyaspartic acid can significantly improve the penetration efficiency of adenosine, enhancing its activating effect.

[0051] Eclipta prostrata extract: As the core ingredient for strengthening the third hair root, Eclipta prostrata is a traditional medicinal and edible hair-nourishing plant, rich in active ingredients such as wedelia lactone, flavonoids, and volatile oils. It can nourish hair matrix cells, promote keratin synthesis, increase hair diameter and tensile strength, strengthen hair roots, and reduce hair breakage. At the same time, it has antioxidant and anti-inflammatory effects, works synergistically with polyaspartic acid to relieve scalp inflammation, and works synergistically with adenosine to consolidate hair follicle vitality.

[0052] The triple synergistic efficiency enhancement mechanism is as follows:

[0053] Barrier-Energy Synergy: Polyaspartic acid repairs the scalp barrier and enhances adenosine penetration efficiency. Adenosine, in turn, empowers hair follicles to promote barrier repair, forming a positive cycle.

[0054] Synergistic anti-inflammatory and nourishing effects: Polyaspartic acid and Eclipta prostrata provide dual anti-inflammatory benefits, eliminating inflammation-induced damage to hair follicles and creating a healthy environment for hair growth.

[0055] Energy-Strengthening Synergy: Adenosine supplies energy to hair follicles, promotes the absorption of nutrients from Eclipta prostrata, accelerates hair root strengthening, and reduces hair breakage and loss.

[0056] The three components work synergistically to achieve a full-chain maintenance process of "anti-inflammatory repair → energy empowerment → hair root strengthening," with effects far superior to any single ingredient or binary combination.

[0057] Auxiliary material system:

[0058] Moisturizing base: glycerin, propylene glycol, sodium hyaluronate, panthenol, to replenish basic hydration and assist in barrier repair;

[0059] Solubilizer: PEG-40 hydrogenated castor oil, which improves the solubility of plant extracts and oil-soluble components;

[0060] Soothing agents: dipotassium glycyrrhizate and bisabolol, which help to reduce inflammation and soothe the skin, further reducing the irritation of the formula;

[0061] Chelating agent: EDTA-2Na, which chelates metal ions in water and improves the stability of the system;

[0062] Mild preservatives: Contains 1,2-hexanediol and p-hydroxyacetophenone, free of parabens and formaldehyde releasers, mild and non-irritating.

[0063] The following examples are based on a total finished product weight of 1000g. All raw materials are cosmetic-grade compliant raw materials, and the preparation equipment is a general-purpose daily chemical vacuum stirred reactor. Efficacy tests were conducted using in vitro cell models, hair tensile strength tests, and human trial evaluations. All tests comply with cosmetic safety and efficacy evaluation standards.

[0064] Example 1:

[0065] This embodiment provides a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. The raw material components, by weight percentage, include:

[0066] Core active ingredients: Sodium polyaspartate 2.0%, adenosine 0.5%, and Eclipta prostrata extract 1.0%. The three ingredients work synergistically to achieve three effects: repairing the scalp's anti-inflammatory barrier, providing energy to hair follicles, and strengthening hair roots.

[0067] Moisturizing base: 5.0% glycerin, 0.05% sodium hyaluronate, 1.0% panthenol;

[0068] Soothing agents: Dipotassium glycyrrhizate 0.2%, Bisabolol 0.05%;

[0069] Solubilizer: 0.3% hydrogenated castor oil (PEG-40);

[0070] Chelating agent: EDTA-2Na 0.05%;

[0071] Preservative system: 1,2-hexanediol 0.8%, p-hydroxyacetophenone 0.3%;

[0072] pH adjuster: Citric acid (appropriate amount);

[0073] Deionized water: Replenish to 100%;

[0074] Finished product pH: 6.0.

[0075] The preparation process of this compound composition includes the following steps:

[0076] Step S1: Add deionized water, EDTA-2Na, glycerol, sodium hyaluronate and panthenol into the reaction vessel, start stirring, heat to 78℃, stir for 20 min until completely dissolved, and homogenize at 2800 r / min for 3 min.

[0077] Step S2: Turn on the cooling water to cool down. When the system temperature drops to 42℃, add sodium polyaspartate, adenosine, Eclipta prostrata extract, dipotassium glycyrrhizate, bisabolol, and PEG-40 hydrogenated castor oil in sequence, and stir at 180r / min for 12min until completely dispersed.

[0078] Step S3: Continue cooling to room temperature, add 1,2-hexanediol and p-hydroxyacetophenone and stir well; adjust the pH to 6.0 with citric acid;

[0079] Step S4: Let stand for 30 minutes to defoam, then filter through 0.45μm micropores to obtain the stock solution of the compound composition.

[0080] Example 2:

[0081] This embodiment provides a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. The raw material components, by weight percentage, include:

[0082] Core active ingredients: Sodium polyaspartate 0.5%, adenosine 0.1%, and Eclipta prostrata extract 0.2%. The three ingredients work synergistically to achieve the triple effects of scalp anti-inflammatory barrier repair, hair follicle energy supply and empowerment, and hair root strengthening and hair retention.

[0083] Moisturizing base: 5.0% glycerin, 0.05% sodium hyaluronate, 1.0% panthenol;

[0084] Soothing agents: Dipotassium glycyrrhizate 0.2%, Bisabolol 0.05%;

[0085] Solubilizer: 0.3% hydrogenated castor oil (PEG-40);

[0086] Chelating agent: EDTA-2Na 0.05%;

[0087] Preservative system: 1,2-hexanediol 0.8%, p-hydroxyacetophenone 0.3%;

[0088] pH adjuster: Citric acid (appropriate amount);

[0089] Deionized water: Replenish to 100%;

[0090] Finished product pH: 5.5.

[0091] The preparation process of this compound composition includes the following steps:

[0092] Step S1: Add deionized water, EDTA-2Na, glycerol, sodium hyaluronate and panthenol into the reaction vessel, start stirring, heat to 78℃, stir for 20 min until completely dissolved, and homogenize at 2800 r / min for 3 min.

[0093] Step S2: Turn on the cooling water to cool down. When the system temperature drops to 42℃, add sodium polyaspartate, adenosine, Eclipta prostrata extract, dipotassium glycyrrhizate, bisabolol, and PEG-40 hydrogenated castor oil in sequence, and stir at 180r / min for 12min until completely dispersed.

[0094] Step S3: Continue cooling to room temperature, add 1,2-hexanediol and p-hydroxyacetophenone and stir well; adjust the pH to 5.5 with citric acid;

[0095] Step S4: Let stand for 30 minutes to defoam, then filter through 0.45μm micropores to obtain the stock solution of the compound composition.

[0096] Example 3:

[0097] This embodiment provides a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening. The raw material components, by weight percentage, include:

[0098] Core active ingredients: Sodium polyaspartate 5.0%, adenosine 2.0%, and Eclipta prostrata extract 3.0%. The three ingredients work synergistically to achieve the triple effects of scalp anti-inflammatory barrier repair, hair follicle energy supply and empowerment, and hair root strengthening and hair retention.

[0099] Moisturizing base: 5.0% glycerin, 0.05% sodium hyaluronate, 1.0% panthenol;

[0100] Soothing agents: Dipotassium glycyrrhizate 0.2%, Bisabolol 0.05%;

[0101] Solubilizer: 0.3% hydrogenated castor oil (PEG-40);

[0102] Chelating agent: EDTA-2Na 0.05%;

[0103] Preservative system: 1,2-hexanediol 0.8%, p-hydroxyacetophenone 0.3%;

[0104] pH adjuster: Citric acid (appropriate amount);

[0105] Deionized water: Replenish to 100%;

[0106] Finished product pH: 6.5.

[0107] The preparation process of this compound composition includes the following steps:

[0108] Step S1: Add deionized water, EDTA-2Na, glycerol, sodium hyaluronate and panthenol into the reaction vessel, start stirring, heat to 78℃, stir for 20 min until completely dissolved, and homogenize at 2800 r / min for 3 min.

[0109] Step S2: Turn on the cooling water to cool down. When the system temperature drops to 42℃, add sodium polyaspartate, adenosine, Eclipta prostrata extract, dipotassium glycyrrhizate, bisabolol, and PEG-40 hydrogenated castor oil in sequence, and stir at 180r / min for 12min until completely dispersed.

[0110] Step S3: Continue cooling to room temperature, add 1,2-hexanediol and p-hydroxyacetophenone and stir well; adjust the pH to 6.5 with citric acid;

[0111] Step S4: Let stand for 30 minutes to defoam, then filter through 0.45μm micropores to obtain the stock solution of the compound composition.

[0112] Comparative Example 1: Contains only polyaspartic acid

[0113] The adenosine and Eclipta prostrata extract were removed, the content of sodium polyaspartate was the same as in Example 1, and the other excipients and processes were the same as in Example 1.

[0114] Comparative Example 2: Contains only adenosine

[0115] Polyaspartic acid and Eclipta prostrata extract were removed. The adenosine content was the same as in Example 1. The other excipients and processes were the same as in Example 1.

[0116] Comparative Example 3: Contains only Eclipta prostrata extract

[0117] Polyaspartic acid and adenosine were removed, and the content of Eclipta prostrata extract was the same as in Example 1. The other excipients and processes were the same as in Example 1.

[0118] Comparative Example 4: Binary Compound: Adenosine and Eclipta prostrata

[0119] Polyaspartic acid was removed, along with 0.5% adenosine and 1.0% Eclipta prostrata extract. The remaining excipients and processes were the same as in Example 1.

[0120] Comparison Example 5: Commercially available ordinary hair care serums

[0121] We selected a mainstream hair care essence from a major brand on the market, which focuses on plant-based hair growth and does not contain the ternary compound system of this invention.

[0122] Efficacy test:

[0123] ① In vitro anti-inflammatory efficacy test

[0124] An LPS-induced human scalp keratinocyte inflammation model was used to detect the inhibition rates of inflammatory factors IL-6 and TNF-α, and to evaluate the anti-inflammatory effect. The higher the inhibition rate, the stronger the anti-inflammatory ability. The detection results are shown in Table 1 below:

[0125] Table 1. Inhibition rates of inflammatory factors IL-6 and TNF-α

[0126] Example 1 78.6% 72.3% Example 2 52.4% 48.7% Example 3 85.9% 80.1% Comparative Example 1 45.2% 41.5% Comparative Example 2 12.8% 10.3% Comparative Example 3 28.6% 25.4% Comparative Example 4 35.7% 31.2% Comparative Example 5 22.3% 19.6%

[0127] Conclusion: The anti-inflammatory effect of the ternary compound of the present invention is significantly better than that of the single component and the binary compound, proving that the synergistic effect of polyaspartic acid as the main anti-inflammatory agent and Eclipta prostrata as the auxiliary anti-inflammatory agent is significant.

[0128] ② Hair follicle energy enhancement test

[0129] Using an in vitro human hair follicle dermal papilla cell model, intracellular ATP content was measured after 24 hours of drug administration and culture. The ATP enhancement rate was calculated to evaluate the energy-enhancing effect on hair follicles. The results are shown in Table 2 below.

[0130] Table 2. ATP content increase rate

[0131] Example 1 68.4% Example 2 32.7% Example 3 82.1% Comparative Example 1 8.5% Comparative Example 2 35.2% Comparative Example 3 5.3% Comparative Example 4 41.6% Comparative Example 5 12.4%

[0132] Conclusion: Adenosine is the core of hair follicle activation, but polyaspartic acid can improve the penetration efficiency of adenosine after repairing the barrier. Therefore, the ATP enhancement rate of the ternary compound is significantly higher than that of adenosine alone and the binary compound, which verifies the barrier-energy synergistic mechanism.

[0133] ③ Hair root strength test

[0134] Hair samples were collected from healthy volunteers, and the hair was soaked in corresponding sample solutions for 30 minutes in groups. After natural drying, the tensile strength of the hair was tested using a universal tensile testing machine, and the tensile strength improvement rate was calculated. The test results are shown in Table 3 below.

[0135] Table 3. Increase in tensile strength of hair

[0136] Example 1 35.7% Example 2 18.2% Example 3 46.3% Comparative Example 1 9.4% Comparative Example 2 12.6% Comparative Example 3 22.8% Comparative Example 4 27.1% Comparative Example 5 10.5%

[0137] Conclusion: Eclipta prostrata is the core ingredient for strengthening hair roots, but after adenosine empowers hair follicles and polyaspartic acid improves the scalp environment, it can promote the absorption of nutrients by the hair matrix. The three-component compound has a significantly better hair root strengthening effect than single components and binary combinations.

[0138] ④ Human trial evaluation test

[0139] Eighty volunteers with symptoms of scalp redness, hair loss, and hair breakage were recruited and randomly divided into eight groups. Each group used the corresponding sample twice daily for 28 consecutive days. The effectiveness rate was statistically analyzed using professional instruments and self-assessment questionnaires. The results are shown in Table 4 below.

[0140] Table 4 Improvement rates for scalp redness, hair loss, and hair breakage

[0141] Example 1 87.5% 80.0% 85.0% Comparative Example 1 50.0% 20.0% 25.0% Comparative Example 2 15.0% 45.0% 30.0% Comparative Example 3 30.0% 35.0% 60.0% Comparative Example 5 25.0% 30.0% 20.0%

[0142] Conclusion: No irritation or allergic reactions were observed in any of the volunteers during the entire testing period, proving that the formula of this invention is mild and safe.

[0143] From the above statistical table, we can conclude that

[0144] 1. The present invention is a ternary compound of polyaspartic acid, adenosine, and Eclipta prostrata, which achieves synergistic effects in three dimensions: anti-inflammatory, hair follicle empowerment, and hair root strengthening. The effect is significantly better than any single component or binary combination, which verifies the scientific nature of the three-layer synergistic mechanism.

[0145] 2. Optimal Example 1 has the best overall performance, with a balanced ratio, outstanding efficacy, and is mild and non-irritating, and can be used as a benchmark formula for mass production.

[0146] 3. The low-temperature preparation process of this invention can effectively protect the active ingredients, has good batch stability, and is suitable for industrial production.

[0147] The raw materials used in this invention are all compliant and commonly used in the cosmetics industry, with wide procurement channels and controllable costs. The preparation process can be completed using a conventional daily chemical stirred reactor, without the need for special customized equipment. The process parameters are precise and controllable, and the batch-to-batch differences in mass production are small. The compound composition can be directly added as a raw material to various products such as scalp essence, hair growth liquid, shampoo, and hair spray. It is suitable for multiple channels such as daily chemical brands, professional hair care institutions, and salon treatments, with broad market demand and strong industrial production and commercial promotion value.

[0148] The following points should be noted in this article:

[0149] 1. The accompanying drawings of the embodiments disclosed herein only relate to the structures involved in the embodiments disclosed herein; other structures can be referred to in a general design.

[0150] 2. Where there is no conflict, the embodiments of this disclosure and the features in the embodiments can be combined with each other to obtain new embodiments.

[0151] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

Claims

1. A compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening, characterized in that, By weight percentage, the active ingredients consist of 0.5%~5.0% polyaspartic acid, 0.1%~2.0% adenosine, and 0.2%~3.0% Eclipta prostrata extract, with the remainder being cosmetically acceptable excipients. The three ingredients work synergistically to achieve the triple effects of scalp anti-inflammatory barrier repair, hair follicle energy supply and empowerment, and hair root strengthening and hair retention.

2. The compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening according to claim 1, characterized in that, The polyaspartic acid is sodium polyaspartate with a number average molecular weight of 3000~10000 Da; the Eclipta prostrata extract is a refined product obtained by water extraction and alcohol precipitation of the whole herb of Eclipta prostrata, wherein the mass content of the active ingredient Wedelia lactone is ≥0.5%.

3. The compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening according to claim 1, characterized in that, The cosmetic excipients acceptable to the cosmetic include one or more of the following: moisturizing base (0.5%~8.0%), solubilizer (0.1%~1.0%), soothing agent (0.05%~0.5%), chelating agent (0.02%~0.1%), and mild preservative system (0.5%~2.0%).

4. The compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening according to claim 3, characterized in that, The moisturizing base is one or more of glycerin, propylene glycol, sodium hyaluronate, and panthenol; the soothing agent is one or two of dipotassium glycyrrhizate and bisabolol.

5. The compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening according to claim 1, characterized in that, The pH of the composition is adjusted to 5.5-6.5, which is weakly acidic and compatible with the physiological environment of the scalp sebum film, reducing the risk of scalp irritation.

6. A method for preparing a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening, characterized in that, Includes the following steps: Step S1: Preparation of aqueous matrix Add deionized water, chelating agent, and moisturizing matrix into the reaction vessel, stir and heat to 75~80℃, and continue stirring until the material is completely dissolved and homogeneously dispersed. Step S2: Low-temperature activation feeding Cool the system to below 45°C, then add polyaspartic acid, adenosine, Eclipta prostrata extract, soothing agent, and solubilizer in sequence, and stir at medium speed until completely dispersed and dissolved. Step S3: Adjust the discharge value Cool the system to room temperature, add a mild preservative system and stir well. Adjust the pH to 5.5-6.5 with citric acid, let it stand to defoam, and then filter it through a microporous filter before discharging.

7. The method for preparing a compound composition for scalp anti-inflammatory repair, hair follicle energy enhancement, and hair root strengthening according to claim 6, characterized in that, In step S2, the temperature of the entire system for adding adenosine and Eclipta prostrata extract does not exceed 45°C, and the stirring speed is controlled at 150~200 r / min to avoid oxidation and degradation of active ingredients caused by high temperature and high shear.

8. The application of the compound composition according to claim 1 in the preparation of scalp care and hair strengthening cosmetics, wherein the cosmetics are used to improve scalp inflammation and redness, repair the scalp barrier, enhance hair follicle energy levels, strengthen hair root tensile strength, and reduce hair breakage and abnormal hair loss.

9. The application according to claim 8, characterized in that, The cosmetic product can be any one of the following formulations: scalp serum, hair growth serum, shampoo, conditioner, scalp massage cream, or leave-in hair spray.

10. The application according to claim 8, characterized in that, The compound composition is added to the finished cosmetic product at a rate of 2% to 20% by mass. It is used 1 to 2 times a day and can significantly improve scalp health and hair root strength after continuous use for more than 28 days.

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