A multi-effect acne-removing composition, its preparation method and application

Abstract

The present application relates to a kind of multi-effect acne-removing composition and its preparation method and application, belong to the field of cosmetics.The acne-removing skin care composition provided by the present application includes PAC zinc, Piao Ning, Radix Lithospermi extract, Fangjia extract, D-pantothenyl alcohol, nicotinamide and hyaluronic acid, seven components are compounded in specific amount range, and significant synergies are generated, realize "source oil control and bacteriostasis-inflammation immediate intervention-barrier long-term repair" whole-link synergistic acne-removing.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology and relates to a multi-effect acne-removing composition, its preparation method, and its application. Background Technology

[0002] Acne is a prevalent skin problem among the modern population, making acne treatment products a necessity in the skincare world. Currently, the market offers a wide variety of acne treatment products, which can be broadly categorized into three main types based on their ingredients, efficacy, and usage scenarios: skincare-focused, drug-based, and medical aesthetic-assisted. Each type of product differs significantly in its mechanism of action, effectiveness, and risks. For example, drug-based products are highly irritating, and long-term use can lead to bacterial resistance and disrupt the skin's microbiome, thus imposing strict usage restrictions. While medical aesthetic procedures can deeply repair stubborn acne-prone skin, their overall adoption rate is low, and they carry significant side effects, such as redness, dryness, sensitivity, and post-treatment hyperpigmentation. Improper aftercare can further damage the skin, posing certain treatment risks. Therefore, compared to drug-based and medical aesthetic-assisted acne treatments, more people prefer to use relatively gentle skincare-based acne treatments. These products often use ingredients such as salicylic acid, fruit acids, and single plant extracts. However, long-term use of acids and retinol can easily damage the skin barrier and cause skin sensitivity. Single plant extracts have limited target areas and can only improve surface skin problems. Although the industry has begun to optimize formulas by combining active ingredients to improve acne treatment effects and reduce irritation through complementary ingredients, the current compounding technology still has significant shortcomings. Most formulas are simply physical mixtures of ingredients and cannot achieve efficient synergistic effects, leaving considerable room for technological optimization. Summary of the Invention

[0003] The purpose of this invention is to provide a multi-effect acne-removing composition, its preparation method, and its application. The raw materials of the acne-removing skin care composition include zinc PAC, piracetam, comfrey root extract, Stephania tetrandra extract, D-panthenol, niacinamide, and hyaluronic acid. The seven ingredients, when combined within a specific dosage range, produce significant synergistic effects, achieving a full-chain synergistic acne removal process of "source oil control and antibacterial action - immediate intervention in inflammation - long-term barrier repair".

[0004] The objective of this invention can be achieved through the following technical solutions: In a first aspect, the present invention provides a multi-effect acne-removing composition, wherein the raw materials of the multi-effect acne-removing composition, by weight, include 0.001-0.5 parts of zinc PAC, 0.0001-0.01 parts of piracetam, 0.01-1 parts of comfrey root extract, 0.01-1 parts of Stephania tetrandra extract, 0.1-5 parts of D-panthenol, 0.5-5 parts of niacinamide, and 0.01-0.5 parts of hyaluronic acid.

[0005] Zinc PAC can inhibit 5α-reductase activity, reduce the conversion of testosterone to dihydrotestosterone, thereby reducing excessive sebum secretion and reducing oil accumulation at the source. This alleviates the problem of clogged hair follicles caused by excess oil, and improves enlarged pores and closed comedones caused by clogged pores. In addition, zinc PAC can regulate the skin surface environment, help enhance the antibacterial and acne-reducing effects, and soothe minor inflammation on the skin surface, reducing the probability of acne breakouts.

[0006] Piocin can interfere with the integrity of bacterial cell membranes through its surface-active action, affecting their metabolic function and thus rapidly killing acne-causing bacteria such as Propionibacterium acnes. Piocin can also reduce the number of bacteria and inflammatory responses, accelerate pimple maturation, and promote the discharge of secretions, thereby relieving redness, swelling, and pustular inflammatory pimples and improving inflammatory skin lesions. This ingredient has strong targeting and can precisely act on acne-causing bacteria, achieving a powerful antibacterial and acne-removing effect even at low concentrations, and is not prone to causing bacterial resistance.

[0007] Comfrey root extract is rich in active substances such as shikonin and acetyl shikonin, which can effectively inhibit the release of inflammatory factors in the skin, reduce inflammatory reactions such as redness, burning, and stinging of acne, and relieve the discomfort of inflammatory acne. At the same time, this ingredient can soothe damaged skin, reduce skin irritation during the acne treatment process, and help fade new acne marks.

[0008] Stephania tetrandra extract is rich in active ingredients such as tebufenozide and tetrandrine, which can inhibit the release of inflammatory mediators in the skin and improve the redness, sensitivity, and fragility of acne-prone skin. Stephania tetrandra extract can also help regulate the skin's microecological balance, reduce skin stress and sensitivity, and thus reduce the risk of recurrent acne.

[0009] D-Panthenol can penetrate the stratum corneum and superficial dermis of the skin, participate in skin cell metabolism and lipid synthesis, promote the production of barrier lipids such as ceramides and fatty acids in the stratum corneum, repair the damaged skin barrier structure, and fill the barrier defects; at the same time, it can deeply moisturize and soothe dry, peeling, and red acne-prone skin, alleviate the slight irritation caused by acne-fighting active ingredients, improve the overall formula gentleness, and maintain the skin condition for a long time.

[0010] Niacinamide can regulate the secretion of sebum from the skin's sebaceous glands, balance the skin's oil and water levels, reduce excessive oil buildup, and help improve oily, acne-prone skin. It can also block melanin transport and deposition, lighten pigmentation and dark spots formed after acne heals, and brighten and even out skin tone. In addition, niacinamide can promote the metabolism and renewal of the skin's stratum corneum, strengthen the skin barrier's resilience, and enhance the acne-prone skin's ability to resist external stimuli.

[0011] Hyaluronic acid can form a breathable and moisturizing protective film on the skin's surface, locking in skin moisture and relieving moisture loss caused by inflammation or barrier damage in acne-prone skin, maintaining the skin's hydration and stability. At the same time, small molecule hyaluronic acid can penetrate deep into the skin, repairing damaged skin tissue, soothing dryness and sensitivity after inflammation, and working synergistically with other active ingredients to achieve the effect of acne removal without dryness and repair without irritation.

[0012] Furthermore, the raw materials of the multi-effect acne-removing composition, by weight, include 0.01-0.1 parts of zinc PAC, 0.001-0.005 parts of piracetam, 0.5-0.9 parts of comfrey extract, 0.1-0.4 parts of tetrandrine extract, 1-3 parts of D-panthenol, 2-4 parts of niacinamide, and 0.05-0.35 parts of hyaluronic acid.

[0013] Secondly, the present invention provides a method for preparing the multi-effect acne-removing composition described in the first aspect, the method comprising the following steps: The formula amounts of zinc PAC, piracetam, comfrey root extract, tetrandrine extract, D-panthenol, niacinamide, and hyaluronic acid are mixed evenly to obtain the multi-effect acne-removing composition.

[0014] Thirdly, the present invention provides the application of the multi-effect acne-removing composition described in the first aspect in the preparation of cosmetics, wherein the cosmetics include toners, creams, masks, serums, essences, or freeze-dried powders.

[0015] Furthermore, the cosmetic product is added at a mass percentage of 0.1wt%-20wt%.

[0016] Fourthly, the present invention provides an essence lotion containing the multi-effect acne-removing composition described in the first aspect.

[0017] Furthermore, the serum also contains excipients acceptable in the cosmetics industry.

[0018] Furthermore, the excipients acceptable in the cosmetics field include solvents, humectants, thickeners, emulsifiers, skin moisturizers, preservatives, and fragrances.

[0019] The beneficial effects of this invention are: This invention provides an acne-removing skincare composition, which is scientifically formulated with PAC zinc, piocinone, comfrey root extract, teosinte extract, D-panthenol, niacinamide and hyaluronic acid to achieve a full-chain synergistic acne removal effect of "source control and antibacterial action - immediate intervention in inflammation - long-term barrier repair".

[0020] Among them, PAC zinc controls oil and unclogs pores at the source by inhibiting 5α-reductase; Piocin rapidly destroys the cell membrane of acne-causing bacteria, effectively improving inflammatory redness and swelling; Comfrey root extract and Stephania tetrandra extract inhibit inflammatory factors through dual pathways, reducing redness, swelling, and burning, and regulating the microecology to reduce recurrence; D-panthenol promotes barrier lipid production to repair damaged structures and soothe irritation; Niacinamide balances oil and water and blocks melanin transport to fade acne scars; Hyaluronic acid forms a moisturizing film and deeply repairs, relieving post-inflammatory dryness. The seven ingredients, when combined within a specific dosage range, produce a significant synergistic effect, achieving a comprehensive acne-removing effect from immediate antibacterial and anti-inflammatory action to long-lasting barrier repair and fading of acne scars. Detailed Implementation

[0021] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0022] PAC zinc was purchased from Guangzhou Huicong Supply Chain Management Co., Ltd., under the product name SpecKare. ® PCAZ; Piocin was purchased from Guangzhou Miaosen Biotechnology Co., Ltd., and the product name is Quaternary Ammonium Salt-73. The Lithospermum root extract was purchased from Huzhou Jiamei Biochemical Products Co., Ltd., and its trade name is Lithospermum extract. The extract of Stephania tetrandra was purchased from Huzhou Jiamei Biochemical Products Co., Ltd., under the trade name Stephania tetrandra A. D-Panthenol was purchased from Guangzhou Huicong Supply Chain Management Co., Ltd., and its product name is D-Panthenol. The niacinamide was purchased from Guangzhou Huicong Supply Chain Management Co., Ltd., and the product name is niacinamide. Sodium hyaluronate was purchased from Bell (Shenzhen) Biotechnology Co., Ltd., and its trade name is sodium hyaluronate.

[0023] Unless otherwise specified, all other materials, reagents, etc. used in all embodiments and comparative examples of this invention are commercially available.

[0024] The composition of Examples 1-5 and Comparative Examples 1-8 is prepared by weighing the corresponding parts by weight of the components and mixing them evenly to obtain the composition.

[0025] Example 1 A multi-effect acne-removing composition is provided, wherein the raw materials of the composition, by weight, include 0.045 parts of zinc PAC, 0.003 parts of piracetam, 0.7 parts of comfrey extract, 0.25 parts of Stephania tetrandra extract, 2 parts of D-panthenol, 3 parts of niacinamide, and 0.2 parts of hyaluronic acid.

[0026] Example 2 A multi-effect acne-removing composition is provided, wherein the raw materials of the composition, by weight, include 0.01 parts of zinc PAC, 0.001 parts of piracetam, 0.5 parts of comfrey extract, 0.1 parts of tetrandrine extract, 1 part of D-panthenol, 2 parts of niacinamide, and 0.05 parts of hyaluronic acid.

[0027] Example 3 A multi-effect acne-removing composition is provided, wherein the raw materials of the composition, by weight, include 0.1 parts of zinc PAC, 0.005 parts of piracetam, 0.9 parts of comfrey extract, 0.4 parts of tetrandrine extract, 3 parts of D-panthenol, 4 parts of niacinamide, and 0.35 parts of hyaluronic acid.

[0028] Example 4 A multi-effect acne-removing composition is provided, wherein the raw materials of the composition, by weight, include 0.001 parts of zinc PAC, 0.0001 parts of piracetam, 0.01 parts of comfrey extract, 0.01 parts of Stephania tetrandra extract, 0.1 parts of D-panthenol, 0.5 parts of niacinamide, and 0.01 parts of hyaluronic acid.

[0029] Example 5 A multi-effect acne-removing composition is provided, wherein the raw materials of the composition, by weight, include 0.5 parts of zinc PAC, 0.01 parts of piracetam, 1 part of comfrey extract, 0.25 parts of tetrandrine extract, 22 parts of D-panthenol, 3 parts of niacinamide, and 0.2 parts of hyaluronic acid.

[0030] Comparative Example 1 Compared with Example 1, the difference is that PAC zinc is removed from the composition and replaced with an equal part by weight of piodin, while the other components and parts by weight remain the same as in Example 1.

[0031] Comparative Example 2 Compared with Example 1, the difference is that piodin in the composition is removed and replaced with an equal part by weight of Lithospermum erythrorhizon root extract, while the other components and parts by weight remain the same as in Example 1.

[0032] Comparative Example 3 Compared with Example 1, the difference is that the Lithospermum erythrorhizon root extract in the composition is removed and replaced with an equal part by weight of Stephania tetrandra extract, while the other components and parts by weight remain the same as in Example 1.

[0033] Comparative Example 4 Compared with Example 1, the difference is that the Stephania tetrandra extract in the composition is removed and replaced with an equal part by weight of D-panthenol, while the other components and parts by weight remain the same as in Example 1.

[0034] Comparative Example 5 Compared with Example 1, the difference is that D-panthenol in the composition is removed and replaced with an equal part by weight of nicotinamide, while the other components and parts by weight remain the same as in Example 1.

[0035] Comparative Example 6 Compared with Example 1, the difference is that nicotinamide in the composition is removed and replaced with an equal part by weight of hyaluronic acid, while the other components and their parts by weight remain the same as in Example 1.

[0036] Comparative Example 7 Compared with Example 1, the difference is that hyaluronic acid is removed from the composition and replaced with an equal part by weight of zinc PAC, while the other components and their parts by weight remain the same as in Example 1.

[0037] Comparative Example 8 Compared with Example 1, the difference is that the raw materials of the composition, by weight, include 0.2 parts of zinc PAC, 0.25 parts of piodin, 2 parts of comfrey extract, 3 parts of Stephania tetrandra extract, 0.003 parts of D-panthenol, 0.045 parts of nicotinamide, and 0.7 parts of hyaluronic acid.

[0038] Test Example 1: Quantitative Fluorescence Assay for Neutral Lipids SZ95 human sebaceous gland cells were placed in Sebomed basal medium containing 10 wt% fetal bovine serum, 5 µg / L epidermal growth factor, 100 U / ml penicillin, and 100 µg / ml streptomycin, and cultured and activated in a 37°C, 5% CO2 incubator. The compositions obtained in Examples 1-5 and Comparative Examples 1-8 were diluted with DMSO to a concentration of 0.1% (v / v) to obtain the test samples.

[0039] Cells were seeded in 96-well cell culture plates (black bottom permeable type) at a density of 1000 cells / well, with 100 μL of culture medium added to each well, and cultured for 24 h. After 48 h of incubation, the supernatant was discarded, and the cells were divided into sample group and control group, with three replicates in each group. The sample group was supplemented with 100 μL of maintenance medium containing 10 ng / mL hydrocortisone and 0.1% of the test sample, while the control group was supplemented with 100 μL of maintenance medium containing 10 ng / mL hydrocortisone. After 48 h of incubation, the supernatant was discarded, and the cells were washed twice with PBS. Nile Red dye diluted in PBS (1 mg / mL, dissolved in acetone, stored at -20°C) was added to the sample group to a final concentration of 10 µg / mL; fluorescein diacetate (FDA) diluted in PBS (5 mg / mL, dissolved in DMSO, stored at -20°C) was added to the control group to a final concentration of 15 µg / mL. After incubation at 37℃ in the dark for 5 min, the fluorescence intensity of each group was detected using a microplate reader. Nile Red was excited at 485 nm, and the emission wavelength at 565 nm was detected. FDA was excited at 494 nm, and the emission wavelength at 523 nm was detected. The results were determined by the ratio of the Nile Red fluorescence OD value (OD value of the sample group) to the FDA fluorescence OD value (OD value of the control group), using the following formula: Intracellular neutral lipid percentage (%) = OD value of sample group / OD value of control group × 100%.

[0040] The results are recorded in Table 1 below.

[0041] Table 1 Example 1 58.31 Example 2 60.15 Example 3 59.06 Example 4 65.42 Example 5 61.84 Comparative Example 1 81.27 Comparative Example 2 76.53 Comparative Example 3 79.86 Comparative Example 4 79.01 Comparative Example 5 77.92 Comparative Example 6 82.14 Comparative Example 7 77.27 Comparative Example 8 74.83 As shown in Table 1, the multi-effect acne-removing composition prepared in this invention can effectively inhibit the secretion of sebum by SZ95 cells and exert a good oil-controlling effect.

[0042] Test Example 2: Antibacterial Experiment of Propionibacterium acnes Liquid thioglycolate medium (FT medium) was prepared, and Propionibacterium acnes was inoculated into the medium and cultured at 37°C for 48 hours to form a bacterial suspension. The multi-effect acne-removing compositions prepared in Examples 1-5 and Comparative Examples 1-8 were used as samples, and DMSO was used to prepare a 1% (v / v) sample solution. 180 μL of the bacterial suspension was added to a 96-well plate, followed by 40 μL of each sample solution to form sample groups. A control group (bacterial suspension without sample groups) was also set up. Each group had three replicates. After culturing for 24 hours, the OD value of each well was measured at 600 nm using a microplate reader. The lower the OD value, the clearer the liquid, the lower the bacterial activity, and the better the antibacterial effect of the composition. The antibacterial rate was calculated using the following formula: Antibacterial rate (%) = (OD value of control group - OD value of sample group) / OD value of control group × 100%; The results are recorded in Table 2 below.

[0043] Table 2 Example 1 98.7 Example 2 96.3 Example 3 97.4 Example 4 91.9 Example 5 94.6 Comparative Example 1 75.8 Comparative Example 2 73.5 Comparative Example 3 76.4 Comparative Example 4 78.2 Comparative Example 5 80.7 Comparative Example 6 79.5 Comparative Example 7 80.9 Comparative Example 8 82.1 As shown in Table 2, the multi-effect acne-removing composition prepared by the present invention can effectively inhibit the growth of Propionibacterium acnes, promote the skin microecological balance, and improve skin condition.

[0044] Application Examples 1-5 and Comparative Application Examples 1-8 The multi-effect acne-removing compositions of Examples 1-5 and Comparative Examples 1-8 were added to the serum at a concentration of 5 wt% along with other excipients to obtain the serums of Application Examples 1-5 and Comparative Application Examples 1-8, respectively. The formulations are shown in Table 3.

[0045] Table 3

[0046] The preparation methods of the serums described in Application Examples 1-5 and Comparative Application Examples 1-8 include the following steps: S1. Mix the solvent, humectant and thickener in the formula, heat to 75°C, homogenize and disperse evenly, keep warm for later use, and obtain phase A; S2. Mix the emulsifier and emollient in the formula, heat to 75°C, stir until completely dissolved, keep warm for later use, and obtain phase B; S3. Mix the preservatives in the formula, heat to 60°C and stir until dissolved to obtain phase C; S4. Heat phase A to 80°C, add phase B while stirring, homogenize and emulsify for 4 minutes, cool to 60°C and add phase C, cool to 40°C and add the multi-effect acne-removing composition and fragrance in the formula, stir evenly to obtain the essence emulsion.

[0047] The present invention also provides a blank application example of essence, which differs from the essence described in application example 1 only in that it does not contain the multi-effect acne-removing composition, and the missing amount is made up with an equal amount of water. The remaining steps and parameters are the same as those in application example 1, and the blank application example of essence is prepared.

[0048] Example 1 of efficacy test: Human patch test Thirty healthy men or women aged 18-40 were selected, and the sample size was no more than 50mm. 2 A qualified spot test apparatus with a depth of approximately 1 mm was used. The sample was placed inside the small chamber of the apparatus, and 0.025 mL of the test sample (the essence prepared in Application Examples 1-5, Control Application Examples 1-8, and the blank application example, along with distilled water) was added. Fifteen test areas of the same size were selected on both arms of the volunteer (1-2 cm apart), and each area was covered with hypoallergenic adhesive tape. The tape was gently pressed with the palm of the hand to ensure even application to the skin. The spot test apparatus was removed after 24 hours. Skin reactions were observed according to the standards in Table 4 at 30 minutes (after the indentation disappeared), 24 hours, and 48 hours after removal of the test apparatus, and the results were recorded. If the average irritation score of the application examples was not higher than that of the blank control group, and no case of grade 2 or higher adverse reaction occurred, the product was deemed safe and non-irritating.

[0049] Table 4 Skin Reaction Grading Standards 0 negative reaction 1 Suspicious reaction, only slight erythema 2 Weak positive reaction (erythema reaction): erythema, infiltration, edema, and papules may be present. 3 Strong positive reaction (herpes reaction): erythema, infiltration, edema, papules; the reaction may extend beyond the test area. 4 Extremely strong positive reaction (confluent herpes simplex reaction): obvious erythema, severe infiltration, edema, confluent herpes simplex; reaction extends beyond the test area. After testing, the average irritation scores of the essences provided in Application Examples 1-5, Comparative Application Examples 1-8, and Blank Application Examples of this invention were not higher than those of the blank control group, and no adverse reactions of grade 2 or above occurred. This indicates that the essences provided by this invention are gentle and non-irritating to human skin and no adverse reactions occurred during use.

[0050] Example 2: Product Efficacy Test In accordance with the principles of human efficacy evaluation in the "Cosmetic Safety Technical Specifications (2015 Edition)," 70 participants aged 18-40 years with at least 5 acne lesions were selected for the test. The participants were randomly divided into 14 groups of 5 people each. They used the test product (essence prepared by application examples 1-5, control application examples 1-8, and blank application example) to evaluate the effects of the test product on acne improvement, redness improvement, pigmentation improvement, and skin barrier repair.

[0051] The testing method was as follows: Subjects were instructed to apply the test product to their face once in the morning and once in the evening, at a dosage of (2.00±0.05) mg / cm³. 2 The test lasted for 14 days. All tests were conducted after the participants were cleaned and sat still for 30 minutes in the experimental environment (temperature 20±1℃, humidity 50±10%). Follow-up data for each indicator were collected on day 1 (initial values) and day 14. Specifically, high-resolution facial images were acquired using VISIA-CR to record the number of acne lesions (micro-lesions caused by acne, new pitted acne scars, inflammatory erythema, and post-inflammatory hyperpigmentation lesions); Colorimeter was used to collect data. ® The ITA° was calculated after measuring the corresponding a*, b*, and L* on the face using the CL440; the Tewameter was used. ® TM Hex measured the TEWL value of the cheekbone; the product's effects on improving acne lesions, redness, pigmentation, and skin barrier damage were evaluated based on various indicators; the improvement effect on acne lesions was expressed as the acne lesion improvement rate, the improvement effect on redness was expressed as the a* value improvement rate, the improvement effect on pigmentation was expressed as the ITA° value improvement rate, and the skin barrier repair effect was expressed as the TEWL value improvement rate. The calculation formulas for each indicator are as follows: Acne lesion improvement rate % = (Number of acne lesions before use - Number of acne lesions after use) / Number of acne lesions before use; ITA°=[Arc tan(L*-50) / b*]×180 / π; a* value improvement rate % = (a* value before use - a* value after use) / a* value before use × 100%; ITA° value improvement rate % = (ITA° value before use - ITA° value after use) / ITA° value before use × 100%; TEWL value improvement rate % = (TEWL value before use - TEWL value after use) / TEWL value before use × 100%; The average of the calculated results for each indicator is recorded in Table 5 below.

[0052] Table 5 Blank control group 3.1 3.3 3.0 2.7 Application Example 1 91.6 29.8 31.9 30.4 Application Example 2 85.4 28.2 29.8 28.3 Application Example 3 88.5 29.1 31.2 29.5 Application Example 4 76.6 24.3 25.6 24.6 Application Example 5 82.1 26.9 28.1 26.8 Comparative Application Example 1 45.6 14.4 17.9 16.7 Comparative Application Example 2 43.3 16.7 18.4 17.1 Comparative Application Example 3 48.7 12.6 14.6 15.9 Comparative Application Example 4 50.5 13.5 15.7 15.2 Comparative Application Example 5 53.2 14.9 16.5 12.3 Comparative Application Example 6 51.4 15.4 13.2 14.4 Comparative Application Example 7 54.3 16.2 17.3 13.5 Comparative Application Example 8 56.4 17.8 19.1 17.9 As shown in Table 5, compared with the comparative application examples, the application examples that added the multi-effect acne-removing composition prepared in this invention can significantly reduce symptoms such as facial acne ulceration, pitting, erythema, and pigmentation, and have good effects in removing acne and inflammation, repairing the skin barrier, fading acne marks, and brightening skin tone.

[0053] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any indirect modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A multi-effect acne-removing composition, characterized in that, The ingredients of the multi-effect acne treatment composition, by weight, include 0.001-0.5 parts of zinc PAC, 0.0001-0.01 parts of piracetam, 0.01-1 parts of comfrey root extract, 0.01-1 parts of Stephania tetrandra extract, 0.1-5 parts of D-panthenol, 0.5-5 parts of niacinamide, and 0.01-0.5 parts of hyaluronic acid.

2. The multi-effect acne-removing composition according to claim 1, characterized in that, The ingredients of the multi-effect acne-removing composition, by weight, include 0.01-0.1 parts of zinc PAC, 0.001-0.005 parts of piracetam, 0.5-0.9 parts of comfrey extract, 0.1-0.4 parts of Stephania tetrandra extract, 1-3 parts of D-panthenol, 2-4 parts of niacinamide, and 0.05-0.35 parts of hyaluronic acid.

3. The method for preparing the multi-effect acne-removing composition according to claim 1 or 2, characterized in that, The preparation method of the multi-effect acne-removing composition includes the following steps: The formula amounts of zinc PAC, piracetam, comfrey root extract, tetrandrine extract, D-panthenol, niacinamide, and hyaluronic acid are mixed evenly to obtain the multi-effect acne-removing composition.

4. The application of the multi-effect acne-removing composition according to claim 1 or 2 in the preparation of cosmetics, wherein the cosmetics include toners, creams, masks, serums, essences, or freeze-dried powders.

5. The application according to claim 4, characterized in that, The cosmetic product is added at a mass percentage of 0.1wt%-20wt%.

6. An essence lotion, characterized in that, The product contains the multi-effect acne-removing composition as described in claim 1 or 2.

7. The essence lotion according to claim 6, characterized in that, It also contains excipients acceptable in the cosmetics industry.

8. The essence lotion according to claim 7, characterized in that, The excipients acceptable in the cosmetics field include solvents, humectants, thickeners, emulsifiers, skin moisturizers, preservatives, and fragrances.

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