Natural herbal compound anti-hair loss composition, preparation method and application thereof

Abstract

The application discloses a natural herbal compound anti-hair loss composition and a preparation method and application thereof. The natural herbal compound anti-hair loss composition is composed of the following components in the form of mass percentage: cypress leaf extract 8-15%, ginseng root extract 5-10%, angelica extract 3-8%, ligustrum lucidum extract 4-9%, nasturtium extract 3-7%, glycyrrhizic acid dipotassium 1-3%, moisturizing auxiliary agent 35-45%, hydrolyzed sodium hyaluronate 0.2-1%, vanillyl butyl ether 0.5-3%, diaminopyrimidine oxide 0.2-2%, and deionized water as the remainder.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products technology, specifically relating to a natural herbal compound anti-hair loss composition, its preparation method, and its application. Background Technology

[0002] Currently, the main categories of anti-hair loss products on the market are chemically synthesized products and single-ingredient plant extract products. They cannot simultaneously achieve multiple effects such as 5α-reductase inhibition, scalp microcirculation acceleration, hair follicle activation, and scalp anti-inflammation. They have poor improvement effects on androgenetic alopecia, postpartum hair loss, and stress-related hair loss. Conventional chemical anti-hair loss products only target and regulate the potassium ion channels of hair follicles and cannot repair the damaged scalp barrier, making hair loss prone to recurrence. Summary of the Invention

[0003] To address the aforementioned technical problems, this invention aims to overcome the shortcomings of existing technologies and provide a compound anti-hair loss composition that promotes circulation through warmth, exhibits a high degree of synergy between herbal ingredients and active components, is suitable for all types of hair loss, and is applicable to sensitive scalps.

[0004] A natural herbal compound anti-hair loss composition comprises the following components in the indicated mass percentages: 8-15% Platycladus orientalis leaf extract, 5-10% ginseng root extract, 3-8% angelica sinensis extract, 4-9% privet fruit extract, 3-7% nasturtium extract, 1-3% dipotassium glycyrrhizate, 35-45% moisturizing agent, 0.2-1% hydrolyzed sodium hyaluronate, 0.5-3% vanillyl butyl ether, 0.2-2% diaminopyrimidine oxide, and deionized water as the balance.

[0005] Optionally, the moisturizing agent includes at least two of 1,3-propanediol, butylene glycol, 1,2-hexanediol, and 1,2-pentanediol.

[0006] Optionally, the natural herbal compound anti-hair loss composition comprises the following components in the indicated weight percentages: 12% Platycladus orientalis leaf extract, 7% ginseng root extract, 5% Angelica sinensis extract, 6% Ligustrum lucidum extract, 5% Nasturtium spp. extract, 2% dipotassium glycyrrhizate, 42% moisturizing agent, 0.6% hydrolyzed sodium hyaluronate, 1.5% vanillyl butyl ether, 1% diaminopyrimidine oxide, and the balance being deionized water; the moisturizing agent is 40% butylene glycol and 2% 1,2-hexanediol.

[0007] Optionally, the Platycladus orientalis leaf extract, the ginseng root extract, the angelica extract, the privet fruit extract, and the nasturtium extract are all extracts obtained by reflux extraction with 40% ethanol.

[0008] A method for preparing the aforementioned natural herbal compound anti-hair loss composition includes the following steps: S1: Mix the deionized water, the moisturizing agent, and the hydrolyzed sodium hyaluronate, heat to 75-80℃, stir to dissolve, and obtain phase A; S2: Cool phase A to below 45°C, and add the Platycladus orientalis leaf extract, ginseng root extract, angelica extract, privet fruit extract, nasturtium extract, and dipotassium glycyrrhizate in sequence, and stir evenly to obtain phase B; S3: The diaminopyrimidine oxide is added to phase B; S4: Add the vanillyl butyl ether, adjust the pH to 5.5-6.5, let stand to defoam, filter, and the product is obtained.

[0009] A hair loss prevention liquid containing the aforementioned natural herbal compound hair loss prevention composition; the natural herbal compound hair loss prevention composition constitutes 3-10% by mass in the hair loss prevention liquid.

[0010] The use of the aforementioned natural herbal compound anti-hair loss composition in the preparation of anti-hair loss shampoo, hair conditioner or scalp care gel.

[0011] Beneficial effects (1) This invention scientifically combines extracts of Platycladus orientalis leaves, ginseng root, angelica sinensis, privet fruit, and nasturtium with dipotassium glycyrrhizate, and then synergistically adds diaminopyrimidine oxide (DPO), achieving multiple effects such as inhibiting DHT production, prolonging the anagen phase of hair follicles, activating telogen effluvium follicles, and anti-inflammatory repair. In vitro enzymatic tests show that the composition of this invention has an effect on 5α- The reductase inhibition rate can reach over 80%, achieving simultaneous hair loss prevention and hair growth.

[0012] (2) By adding vanillyl butyl ether, a mild and controllable warming sensation can be generated on the scalp after application, causing local capillary dilation, accelerating scalp blood circulation, and significantly increasing the transdermal cumulative permeability of active ingredients such as arborvitae leaf flavonoids, ginsenosides, and DPO. The warming sensation forms a synergistic amplification effect with the blood-activating components of angelica and ginseng, making it easier for the effective ingredients to reach the hair follicle roots and improving bioavailability.

[0013] (3) Nasturtium extract combined with dipotassium glycyrrhizate effectively inhibits the release of Malassezia scalp and inflammatory factors, improving seborrheic scalp inflammation; hydrolyzed sodium hyaluronate and water-soluble plant polysaccharides work together to repair the scalp barrier and reduce transepidermal water loss. In some embodiments, after 8 weeks of use, the average diameter of the hair in the subjects increased significantly (+0.018 mm), the dryness and thinning of the hair shaft were significantly improved, and the amount of hair loss decreased. Detailed Implementation

[0014] An embodiment of the present invention provides a natural herbal compound anti-hair loss composition, comprising the following components in the indicated mass percentages: 8-15% Platycladus orientalis leaf extract, 5-10% ginseng root extract, 3-8% angelica sinensis extract, 4-9% privet fruit extract, 3-7% nasturtium extract, 1-3% dipotassium glycyrrhizate, 35-45% moisturizing agent, 0.2-1% hydrolyzed sodium hyaluronate, 0.5-3% vanillyl butyl ether, 0.2-2% diaminopyrimidine oxide, and deionized water as the balance. In this embodiment, the Platycladus orientalis leaf extract, ginseng root extract, angelica sinensis extract, privet fruit extract, nasturtium extract, and dipotassium glycyrrhizate are scientifically compounded, and diaminopyrimidine oxide (DPO) is synergistically added to achieve multiple effects such as inhibiting DHT production, prolonging the hair follicle growth phase, activating the resting phase hair follicles, and anti-inflammatory repair. In vitro enzymatic tests show that the composition of the present invention has an effect on 5α-... The reductase inhibition rate can reach over 80%, achieving simultaneous hair loss prevention and hair growth. Nasturtium extract combined with dipotassium glycyrrhizate effectively inhibits the release of Malassezia and inflammatory factors on the scalp, improving seborrheic scalp inflammation. Hydrolyzed sodium hyaluronate and water-soluble plant polysaccharides work together to repair the scalp barrier and reduce transdermal water loss. The addition of vanillyl butyl ether produces a gentle, controllable warming sensation on the scalp after application, causing local capillary dilation, accelerating scalp blood circulation, and significantly increasing the transdermal accumulation of active ingredients such as Platycladus orientalis leaf flavonoids, ginsenosides, and DPO. The warming sensation, combined with the blood-activating components of Angelica sinensis and ginseng, creates a synergistic amplification effect, making it easier for the active ingredients to reach the hair follicle roots and improving bioavailability.

[0015] It is understandable that in the natural herbal compound anti-hair loss composition, the sum of the mass percentages of each component is 100%.

[0016] In some embodiments, the moisturizing aids include at least two of 1,3-propanediol, butylene glycol, 1,2-hexanediol, and 1,2-pentanediol. These moisturizing aids have lower skin irritation and better moisturizing properties, while also acting as solvents to improve the solubility of diaminopyrimidine oxides, ensuring their stable dispersion in the formulation.

[0017] In some embodiments, the natural herbal compound anti-hair loss composition comprises the following components in the indicated weight percentages: 12% Platycladus orientalis leaf extract, 7% ginseng root extract, 5% angelica sinensis extract, 6% privet fruit extract, 5% nasturtium extract, 2% dipotassium glycyrrhizate, 42% moisturizing agent, 0.6% hydrolyzed sodium hyaluronate, 1.5% vanillyl butyl ether, 1% diaminopyrimidine oxide, and the balance being deionized water; the moisturizing agent is 40% butylene glycol and 2% 1,2-hexanediol. Vanillyl butyl ether provides a mild and lasting warming sensation and, through TRPV1 receptor mediation, dilates scalp capillaries, accelerates blood flow, thereby enabling subsequent blood-activating ingredients such as ginseng and angelica sinensis to reach the hair follicle roots more quickly.

[0018] In some embodiments, the extracts of Platycladus orientalis leaf, ginseng root, angelica sinensis, privet fruit, and nasturtium are extracts obtained by reflux extraction with 40% ethanol.

[0019] Another embodiment of the present invention provides a method for preparing the above-mentioned natural herbal compound anti-hair loss composition, comprising the following steps: S1: Mix deionized water, moisturizing agent, and hydrolyzed sodium hyaluronate, heat to 75-80℃, stir to dissolve, and obtain phase A; S2: Cool phase A to below 45℃, then add arborvitae leaf extract, ginseng root extract, angelica extract, privet fruit extract, nasturtium extract, and dipotassium glycyrrhizate in sequence, and stir well to obtain phase B; S3: Add diaminopyrimidine oxide to phase B; S4: Add vanillyl butyl ether, adjust the pH to 5.5-6.5, let stand to defoam, filter, and the product is ready.

[0020] Optionally, the reagent used to adjust the pH is citric acid or sodium hydroxide solution.

[0021] Another embodiment of the present invention provides an anti-hair loss liquid containing the above-mentioned natural herbal compound anti-hair loss composition. Optionally, the natural herbal compound anti-hair loss composition accounts for 3-10% by mass in the anti-hair loss liquid.

[0022] Another embodiment of the present invention provides the application of the above-mentioned natural herbal compound anti-hair loss composition in the preparation of anti-hair loss shampoo, hair conditioner, or scalp care gel. Optionally, the application is targeted at people with androgenetic alopecia, postpartum alopecia, or stress-related alopecia.

[0023] The following are examples and comparative examples.

[0024] Example 1 In this embodiment, the composition consists of the following components in the indicated mass percentages: 12% Platycladus orientalis leaf extract, 7% ginseng root extract, 5% Angelica sinensis extract, 6% Ligustrum lucidum extract, 5% Nasturtium rotundum extract, 2% dipotassium glycyrrhizate, 40% butylene glycol, 2% 1,2-hexanediol, 0.6% hydrolyzed sodium hyaluronate, 1.5% vanillyl butyl ether, 1% diaminopyrimidine oxide, and the balance being deionized water.

[0025] The composition was obtained by the following preparation method: S1: Mix deionized water, butanediol, 1,2-hexanediol and hydrolyzed sodium hyaluronate, heat to 75°C, stir to dissolve, and obtain phase A; S2: Cool phase A to 45℃, then add arborvitae leaf extract, ginseng root extract, angelica extract, privet fruit extract, nasturtium extract, and dipotassium glycyrrhizate in sequence, and stir well to obtain phase B. S3: Add diaminopyrimidine oxide to phase B; S4: Add vanillyl butyl ether, adjust the pH to 5.5-6.5, let stand to defoam, filter, and the product is ready.

[0026] Example 2 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 8% Platycladus orientalis leaf extract, 10% ginseng root extract, 3% Angelica sinensis extract, 4% Ligustrum lucidum extract, 7% Nasturtium spp. extract, 1% dipotassium glycyrrhizate, 43% butylene glycol, 2% 1,2-hexanediol, 0.2% hydrolyzed sodium hyaluronate, 0.5% vanillyl butyl ether, 2% diaminopyrimidine oxide, and the balance being deionized water.

[0027] Example 3 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 15% Platycladus orientalis leaf extract, 5% ginseng root extract, 8% Angelica sinensis extract, 9% Ligustrum lucidum extract, 3% Nasturtium spp. extract, 3% dipotassium glycyrrhizate, 33% butylene glycol, 2% 1,2-hexanediol, 1% hydrolyzed sodium hyaluronate, 3% vanillyl butyl ether, 0.2% diaminopyrimidine oxide, and the balance being deionized water.

[0028] Comparative Example 1 The difference from Example 1 is that the diaminopyrimidine oxide was replaced with deionized water in the same mass percentage.

[0029] Comparative Example 2 The difference from Example 1 is that vanillyl butyl ether is replaced with deionized water of the same mass percentage.

[0030] Test case (1) In vitro 5α-reductase inhibition rate test: The in vitro enzyme-linked immunosorbent assay (ELISA) was used for determination. The results are shown in Table 1.

[0031] Table 1

[0032] As shown in Table 1, the inhibition rate of 5α-reductase was significantly improved when diaminopyrimidine oxide was combined with Platycladus orientalis leaves.

[0033] (2) In vitro transdermal absorption test (Franz diffusion cell): using excised porcine skin, the cumulative permeation of diaminopyrimidine oxide was measured over 24 hours. The results are shown in Table 2.

[0034] Table 2

[0035] As can be seen from Table 2, the thermal effect generated by vanillyl butyl ether can effectively dilate pores and capillaries, and significantly improve the transdermal absorption rate of active ingredients.

[0036] (3) Evaluation of efficacy in human trials (8 weeks) Subjects: 60 patients with androgenetic alopecia were randomly divided into two groups (Example 1 group and Comparative Example 1 group).

[0037] How to use: Apply to the scalp and massage for 3 minutes every morning and evening.

[0038] Test metrics: Hair count: Phototrichogram software was used to analyze photographs of the top of the head.

[0039] Hair diameter: The average diameter of hair in the target area.

[0040] Scalp itching score: blinded assessment by a dermatologist (0-10 points).

[0041] The test results are shown in Table 3.

[0042] Table 3

[0043] As can be seen from Table 3, the composition of the present invention has a good hair growth effect.

[0044] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0045] For those skilled in the art, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. A natural herbal compound anti-hair loss composition, characterized in that, It is composed of the following components in the indicated mass percentages: 8-15% Platycladus orientalis leaf extract, 5-10% ginseng root extract, 3-8% angelica sinensis extract, 4-9% privet fruit extract, 3-7% nasturtium extract, 1-3% dipotassium glycyrrhizate, 35-45% moisturizing agent, 0.2-1% hydrolyzed sodium hyaluronate, 0.5-3% vanillyl butyl ether, 0.2-2% diaminopyrimidine oxide, and the balance being deionized water.

2. The natural herbal compound anti-hair loss composition as described in claim 1, characterized in that, The moisturizing agent includes at least two of 1,3-propanediol, butylene glycol, 1,2-hexanediol, and 1,2-pentanediol.

3. The natural herbal compound anti-hair loss composition as described in claim 1, characterized in that, It is composed of the following components in the indicated mass percentages: 12% of the Platycladus orientalis leaf extract, 7% of the ginseng root extract, 5% of the angelica sinensis extract, 6% of the privet fruit extract, 5% of the nasturtium extract, 2% of the dipotassium glycyrrhizate, 42% of the moisturizing agent, 0.6% of the hydrolyzed sodium hyaluronate, 1.5% of the vanillyl butyl ether, 1% of the diaminopyrimidine oxide, and the balance being deionized water; the moisturizing agent is 40% by mass of butylene glycol and 2% by mass of 1,2-hexanediol.

4. The natural herbal compound anti-hair loss composition according to any one of claims 1 to 3, characterized in that, The Platycladus orientalis leaf extract, the ginseng root extract, the angelica extract, the privet fruit extract, and the nasturtium extract are all extracts obtained by reflux extraction with 40% ethanol.

5. A method for preparing a natural herbal compound anti-hair loss composition according to any one of claims 1 to 4, characterized in that, Includes the following steps: S1: Mix the deionized water, the moisturizing agent, and the hydrolyzed sodium hyaluronate, heat to 75-80℃, stir to dissolve, and obtain phase A; S2: Cool phase A to below 45°C, and add the Platycladus orientalis leaf extract, ginseng root extract, angelica extract, privet fruit extract, nasturtium extract, and dipotassium glycyrrhizate in sequence, and stir evenly to obtain phase B; S3: The diaminopyrimidine oxide is added to phase B; S4: Add the vanillyl butyl ether, adjust the pH to 5.5-6.5, let stand to defoam, filter, and the product is obtained.

6. An anti-hair loss liquid, characterized in that, The natural herbal compound anti-hair loss composition contains any one of claims 1 to 5; the natural herbal compound anti-hair loss composition is present in the anti-hair loss solution at a mass percentage of 3 to 10%.

7. The use of any one of the natural herbal compound anti-hair loss compositions according to claims 1 to 5 in the preparation of anti-hair loss shampoos, hair conditioners, or scalp care gels.

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