An anti-dandruff composition, a method for preparing the same and a shampoo

Abstract

The application discloses a dandruff-removing composition, a preparation method thereof and a shampoo. The dandruff-removing composition is composed of the following components in the following mass percentages: 3-6% of an extract of Melaleuca alternifolia, 2-5% of an extract of Magnolia officinalis bark, 1-4% of an extract of Dictamnus dasycarpus root bark, 0.5-2% of sorbitan caprylate, 1-3% of dichlorobenzyl alcohol, 35-50% of 1,3-propanediol, 5-10% of sodium cocamido propyl PG-dimethyl phosphate, and the balance of deionized water. The application provides a compounding idea for a single dandruff-removing purpose, the composition has simple components and clear action targets, is specific to the generation mechanism of dandruff, and avoids instability in compounding and efficacy antagonism caused by multifunctional compounding.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products technology, specifically relating to an anti-dandruff composition, its preparation method, and a shampoo. Background Technology

[0002] Shampoo is one of the most widely used daily chemical products. Currently, the shampoos on the market have the following problems: (1) redundant and mixed functions. Most anti-dandruff formulas have multiple additional functions such as oil control, anti-itch, soothing, scalp repair, and hair nourishment. In order to adapt to the multi-functional compound, a large number of emulsifiers, moisturizers, and soothing agents are added, which interferes with the target of antibacterial active ingredients, dilutes the effective concentration of anti-dandruff, and has poor targeted effect on stubborn and recurring dandruff. (2) strong dependence on chemical anti-dandruff ingredients. Mainstream chemical anti-dandruff agents such as zinc pyrithione, ketoconazole, and piroctone olamine salt have excellent short-term antibacterial effects, but long-term use will induce gene mutation of Malassezia, resulting in drug resistance of strains. At the same time, it destroys the original beneficial flora of the scalp, and dandruff rebounds after discontinuation.

[0003] Therefore, it is necessary to further improve traditional anti-dandruff shampoos. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention aims to overcome the shortcomings of existing technologies and provide a plant-based compound anti-dandruff composition. This composition, through the synergistic effect of specific proportions of plant-based active ingredients, effectively removes Malassezia and blocks abnormal shedding of the scalp's stratum corneum, achieving a specific and long-lasting anti-dandruff effect.

[0005] An anti-dandruff composition comprising the following components in the indicated mass percentages: Melaleuca alternifolia extract: 3%~6% Magnolia officinalis bark extract: 2%~5% Dictamnus dasycarpus root bark extract: 1%~4% Sorbitan octanoate: 0.5%~2%, Dichlorobenzyl alcohol: 1%~3%, 1,3-Propanediol: 35%~50% Sodium cocamidopropyl PG-dimethyl phosphate: 5%~10% Deionized water: Balance.

[0006] Optionally, the mass ratio of the Melaleuca alternifolia extract to the Magnolia officinalis bark extract is (1.5~2.5):1.

[0007] Optionally, the mass ratio of the Melaleuca alternifolia extract to the Dictamnus dasycarpus root bark extract is (2.8~3.5):1.

[0008] Optionally, the mass ratio of sorbitan octanoate to dichlorobenzyl alcohol is (0.5~1):1.

[0009] Optionally, the preparation method of the Melaleuca alternifolia extract is as follows: Take dried branches and leaves of Melaleuca alternifolia, crush them, and pass them through a 10-20 mesh sieve; Extracting volatile oils by steam distillation: The crushed raw material is put into a distillation vessel, 6 to 8 times the amount of deionized water is added, the mixture is heated to boiling and maintained for 1.5 to 2.5 hours, and the distillate is collected. The distillate is separated into oil and water, and the upper layer of essential oil is collected for later use. After distillation, the solid phase is drained, and 8-10 times the volume of 50-70% ethanol is added. The mixture is then extracted by hot reflux at 60-70℃ for 1-1.5 hours. The extraction is repeated 2-3 times. The extracts are combined, filtered, and the ethanol is concentrated to obtain an alcohol extract with a relative density of 1.05-1.1. The extract was mixed with the upper essential oil to obtain Melaleuca alternifolia extract.

[0010] Optionally, the preparation method of the Magnolia officinalis bark extract is as follows: Take dried Magnolia officinalis bark, pulverize it and pass it through a 10-20 mesh sieve. Add 8-12 times the volume of 75-85% ethanol and extract by hot reflux in a water bath at 70-80℃ for 1.5-2 hours. Repeat the extraction 2-3 times, combine the extracts, filter, concentrate and recover the ethanol to obtain the extract. Purification was performed using macroporous adsorption resin: The extract was diluted with water and loaded onto an AB-8 macroporous adsorption resin column. It was first washed with deionized water until the eluent was colorless, and then eluted with 60-80% ethanol by volume. The eluent was collected, concentrated under reduced pressure, dried, and pulverized to obtain the Magnolia officinalis bark extract.

[0011] Optionally, the preparation method of the Dictamnus dasycarpus root bark extract is as follows: Take dried Dictamnus dasycarpus root bark, crush it and pass it through a 20-40 mesh sieve. Add 10-15 times the amount of 70-80% ethanol by volume, and extract it by hot reflux at 60-70℃ for 1-1.5 hours. Repeat the extraction 2-3 times, combine the extracts, filter, concentrate and recover the ethanol to obtain the extract. After dispersing the extract in water, extract it 2-3 times with ethyl acetate, combine the ethyl acetate phases, recover the solvent under reduced pressure until dry, and pulverize to obtain the extract of Dictamnus dasycarpus root bark.

[0012] A method for preparing the above-mentioned anti-dandruff composition includes the following steps: S1: Under light-protected conditions, heat 1,3-propanediol to 45~50℃, add Melaleuca alternifolia extract, Magnolia officinalis bark extract and Dictamnus dasycarpus root bark extract, stir to dissolve, stirring speed is 300~500 rpm, stirring time is 20~30 min; S2: Add deionized water to the mixture obtained in step S1 and cool it to 35~40℃; S3: Add sorbitan octanoate and dichlorobenzyl alcohol, and stir until well mixed.

[0013] An anti-dandruff shampoo comprising the above-mentioned anti-dandruff composition, wherein the anti-dandruff composition accounts for 1% to 5% of the total mass of the anti-dandruff shampoo.

[0014] Beneficial effects This invention proposes a compound formulation approach with a single dandruff-removing purpose. The composition has simple components and a clear target, specifically targeting the dandruff formation mechanism, thus avoiding instability and efficacy antagonism caused by multifunctional compound formulations. Detailed Implementation

[0015] In their research on dandruff, the inventors of this invention discovered that the core pathological mechanism of dandruff production is as follows: Malassezia, a resident bacterium on the scalp, decomposes trace amounts of sebum on the scalp, producing free fatty acids, which induces cell cycle disorder in the stratum corneum of the scalp, causing keratinocytes to clump together and shed abnormally, thus forming visible scales; the root cause of dandruff recurrence is that Malassezia cannot be effectively inhibited in the long term and the scalp flora homeostasis is disrupted.

[0016] Based on this, the present invention provides an anti-dandruff composition comprising the following components in the indicated mass percentages: Melaleuca alternifolia extract: 3%~6%, Magnolia officinalis bark extract: 2%~5%, Dictamnus dasycarpus root bark extract: 1%~4%, Sorbitan caprylate: 0.5%~2%, Dichlorobenzyl alcohol: 1%~3%, 1,3-propanediol: 35%~50%, Sodium cocamidopropyl PG-dimethyl phosphate (biomimetic phospholipid): 5%~10%, and deionized water: balance. This composition, with its single-purpose anti-dandruff approach, features simple components and a clearly defined target, specifically addressing the mechanism of dandruff formation, thus avoiding instability and antagonistic effects caused by multifunctional compounding.

[0017] Among them, Melaleuca alternifolia extract is the core broad-spectrum antibacterial agent, which disrupts the cell wall integrity of Malassezia, inhibits bacterial reproduction, and locks in live bacteria on the surface of the scalp. Magnolia officinalis bark extract can target and inhibit Malassezia lipase activity, blocking the bacterial decomposition of sebum to produce dandruff-causing fatty acids, thus cutting off the cause of dandruff at its source. Dictamnus dasycarpus root bark extract can specifically bind to Malassezia membrane transport proteins, inhibit bacterial colonization of scalp hair follicles, deeply cleanse hidden bacteria, and make up for the shortcomings of conventional plant extracts in targeting hair follicle bacteria. Sorbitan caprylate, as a non-ionic, mild antibacterial adjuvant, can emulsify and solubilize plant resin impurities while inhibiting Malassezia spore germination and blocking bacterial proliferation and iteration. (The structure of sorbitan caprylate is similar to the phospholipid structure of microbial cell membranes, allowing it to embed itself in the cell membrane, altering its permeability and helping other antibacterial components enter the cell to exert their effects. Therefore, it can play a good synergistic role, enhancing the antibacterial effect of other components.) Dichlorobenzyl alcohol can serve as a trace-targeted antibacterial adjuvant, improving antibacterial stability under high and low temperature conditions and extending the storage time of the composition. (Dichlorobenzyl alcohol itself also has a good inhibitory effect on fungi and anti-inflammatory effects.) 1,3-Propanediol is less irritating than propylene glycol, can improve the solubility of all plant active ingredients, prevent composition stratification, and also has auxiliary antibacterial capabilities without producing secondary moisturizing and oil-controlling effects.

[0018] Furthermore, in this invention, by combining the extracts of Melaleuca alternifolia, Magnolia officinalis bark, and Dictamnus dasycarpus root bark in a specific ratio, a significant synergistic antibacterial effect is produced, with the MIC value being significantly lower than that of any single ingredient or any combination of two, effectively preventing tolerance problems that are easily caused by single plant extracts.

[0019] Furthermore, in this invention, the extract of Magnolia officinalis bark can inhibit NF... The κB and related pathways reduce excessive proliferation of keratinocytes and scaling, enabling this invention to directly intervene in abnormal scaling while reducing Malassezia load.

[0020] Furthermore, in this invention, sorbitan caprylate, as a nonionic surfactant, can disrupt the lipid arrangement of fungal cell membranes and assist dichlorobenzyl alcohol in penetrating the cell wall, achieving an effective antibacterial concentration at low dosages. At the same time, the combination of the two reduces the amount of single chemical preservatives used, which is in line with the trend of green cosmetics and avoids the risk of sensitization caused by traditional broad-spectrum preservatives.

[0021] Optionally, the mass percentage of Melaleuca alternifolia extract in the anti-dandruff composition may be 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, etc.

[0022] Optionally, the mass percentage of Magnolia officinalis bark extract in the anti-dandruff composition may be 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, etc.

[0023] Optionally, the mass percentage of Dictamnus dasycarpus root bark extract in the anti-dandruff composition may be 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, etc.

[0024] Optionally, the mass percentage of sorbitan caprylate in the anti-dandruff composition may be 0.5%, 1%, 1.5%, 2%, etc.

[0025] Optionally, the mass percentage of dichlorobenzyl alcohol in the anti-dandruff composition may be 1%, 2%, 3%, etc.

[0026] Optionally, the mass percentage of 1,3-propanediol in the anti-dandruff composition may be 35%, 40%, 45%, 50%, etc.

[0027] Optionally, the mass percentage of sodium cocamidopropyl PG-dimethyl phosphate in the anti-dandruff composition may be 5%, 6%, 7%, 8%, 9%, 10%, etc.

[0028] Understandably, the total mass percentage of the anti-dandruff composition of Melaleuca alternifolia extract, Magnolia officinalis bark extract, Dictamnus dasycarpus root bark extract, sorbitan caprylate, dichlorobenzyl alcohol, 1,3-propanediol, and deionized water is 100%.

[0029] In some embodiments, the mass ratio of Melaleuca alternifolia extract to Magnolia officinalis bark extract is (1.5~2.5):1, for example, 1.5:1, 1.8:1, 2:1, 2.3:1, 2.5:1, etc.

[0030] In some embodiments, the mass ratio of Melaleuca alternifolia extract to Dictamnus dasycarpus root bark extract is (2.8~3.5):1, for example, 2.8:1, 3:1, 3.3:1, 3.5:1, etc.

[0031] In some embodiments, the mass ratio of sorbitan caprylate to dichlorobenzyl alcohol is (0.5~1):1, for example, 0.5:1, 0.6:1, 0.7:1, 0.8:1, 0.9:1, 1:1, etc.

[0032] In some embodiments, the preparation method of Melaleuca alternifolia extract is as follows: take dried Melaleuca alternifolia branches and leaves, crush them and pass them through a 10-20 mesh sieve; extract the volatile oil by steam distillation: put the crushed raw material into a distillation vessel, add 6-8 times the amount of deionized water, heat to boiling and maintain for 1.5-2.5 h, and collect the distillate; separate the oil and water in the distillate and take the upper essential oil for later use; drain the solid phase after distillation, add 8-10 times the amount of 50-70% ethanol (by volume), and reflux extract at 60-70℃ for 1-1.5 h, repeat the extraction 2-3 times, combine the extracts, filter, concentrate and recover the ethanol to obtain an alcohol extract with a relative density of 1.05-1.1; mix the extract with the upper essential oil to obtain Melaleuca alternifolia extract.

[0033] In some embodiments, the preparation method of Magnolia officinalis bark extract is as follows: Take dried Magnolia officinalis bark, pulverize it, and pass it through a 10-20 mesh sieve. Add 8-12 times the volume of 75-85% ethanol and extract by hot reflux at 70-80℃ for 1.5-2 hours. Repeat the extraction 2-3 times, combine the extracts, filter, concentrate and recover the ethanol to obtain an extract. Purify using macroporous adsorption resin: Dilute the extract with water and load it onto an AB-8 type macroporous adsorption resin column. First, wash with deionized water until the eluent is colorless, then elute with 60-80% ethanol. Collect the eluent, concentrate under reduced pressure, dry, and pulverize to obtain Magnolia officinalis bark extract.

[0034] In some embodiments, the preparation method of Dictamnus dasycarpus root bark extract is as follows: take dried Dictamnus dasycarpus root bark, pulverize it and pass it through a 20-40 mesh sieve, add 10-15 times the amount of 70-80% ethanol (by volume), and extract under reflux at 60-70°C for 1-1.5 hours. Repeat the extraction 2-3 times, combine the extracts, filter, concentrate and recover the ethanol to obtain an extract; disperse the extract in water, extract with ethyl acetate 2-3 times, combine the ethyl acetate phases, recover the solvent under reduced pressure until dry, pulverize, and obtain Dictamnus dasycarpus root bark extract.

[0035] The present invention also provides a method for preparing the above-mentioned anti-dandruff composition, comprising the following steps: S1: Under light-protected conditions, heat 1,3-propanediol to 45~50℃, add Melaleuca alternifolia extract, Magnolia officinalis bark extract and Dictamnus dasycarpus root bark extract, stir to dissolve, stirring speed is 300~500 rpm, stirring time is 20~30 min; S2: Add deionized water to the mixture obtained in step S1 and cool it to 35~40℃; S3: Add sorbitan octanoate and dichlorobenzyl alcohol, and stir until well mixed.

[0036] The present invention also provides an anti-dandruff shampoo comprising the above-mentioned anti-dandruff composition. Optionally, the anti-dandruff composition accounts for 1% to 5% of the total mass of the anti-dandruff shampoo. For example, the anti-dandruff composition accounts for 1%, 2%, 3%, 4%, 5% of the total mass of the anti-dandruff shampoo, etc.

[0037] The following are examples and comparative examples.

[0038] The Melaleuca alternifolia extract used in the examples and comparative examples was prepared as follows: Dried Melaleuca alternifolia branches and leaves were pulverized and passed through a 20-mesh sieve. The volatile oil was extracted using steam distillation: the pulverized raw material was placed in a distillation vessel, 7 times the volume of deionized water was added, and the mixture was heated to boiling and maintained for 2 hours. The distillate was collected. The distillate was separated into oil and water, and the upper essential oil was collected for later use. The solid phase after distillation was drained, and 8 times the volume of 50% ethanol was added. The mixture was refluxed at 60°C for 1 hour, and the extraction was repeated 3 times. The extracts were combined, filtered, and the ethanol was concentrated to obtain an alcohol extract with a relative density of 1.1. The extract was mixed with the upper essential oil to obtain the Melaleuca alternifolia extract.

[0039] The Magnolia officinalis bark extract used in the examples and comparative examples was prepared as follows: Dried Magnolia officinalis bark was pulverized and passed through a 20-mesh sieve. Ten times the volume of 80% ethanol was added, and the mixture was extracted by reflux at 75°C for 2 hours. This extraction was repeated three times. The extracts were combined, filtered, and concentrated to recover the ethanol, yielding a paste. Purification was performed using macroporous adsorption resin: The paste was diluted with water and loaded onto an AB-8 macroporous adsorption resin column. It was first washed with deionized water until the eluent was colorless, then eluted with 60% ethanol. The eluent was collected, concentrated under reduced pressure, dried, and pulverized to obtain the Magnolia officinalis bark extract.

[0040] The Dictamnus dasycarpus root bark extract used in the examples and comparative examples was prepared by the following method: Dried Dictamnus dasycarpus root bark was pulverized and passed through a 20-mesh sieve. 15 times the volume of 70% ethanol was added, and the mixture was extracted under reflux at 70°C for 1.5 hours. The extraction was repeated twice. The extracts were combined, filtered, and the ethanol was concentrated to obtain a paste. The paste was dispersed in water and extracted three times with ethyl acetate. The ethyl acetate phases were combined, the solvent was recovered under reduced pressure until dry, and the extract was pulverized to obtain the Dictamnus dasycarpus root bark extract.

[0041] Example 1 In this embodiment, the composition consists of the following components in the indicated mass percentages: 5% Melaleuca alternifolia extract, 3% Magnolia officinalis bark extract, 1.5% Dictamnus dasycarpus root bark extract, 0.8% sorbitan caprylate, 2% dichlorobenzyl alcohol, 40% 1,3-propanediol, 8% sodium cocamidopropyl PG-dimethyl phosphate, and the balance being deionized water.

[0042] The composition is prepared as follows: S1: Under light-protected conditions, heat 1,3-propanediol to 45°C, add Melaleuca alternifolia extract, Magnolia officinalis bark extract and Dictamnus dasycarpus root bark extract, stir to dissolve, stir at 400 rpm for 20 min.

[0043] S2: Add deionized water to the mixture obtained in step S1 and cool it to 35°C.

[0044] S3: Add sorbitan octanoate and dichlorobenzyl alcohol, and stir until well mixed.

[0045] Example 2 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 5% Melaleuca alternifolia extract, 3% Magnolia officinalis bark extract, 2% Dictamnus dasycarpus root bark extract, 1.2% sorbitan caprylate, 3% dichlorobenzyl alcohol, 40% 1,3-propanediol, 8% sodium cocamidopropyl PG-dimethyl phosphate, and the balance being deionized water.

[0046] Example 3 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 6% Melaleuca alternifolia extract, 2% Magnolia officinalis bark extract, 4% Dictamnus dasycarpus root bark extract, 2% sorbitan caprylate, 1% dichlorobenzyl alcohol, 50% 1,3-propanediol, 10% sodium cocamidopropyl PG-dimethyl phosphate, and the balance being deionized water.

[0047] Example 4 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 3% Melaleuca alternifolia extract, 2% Magnolia officinalis bark extract, 1% Dictamnus dasycarpus root bark extract, 0.5% sorbitan caprylate, 3% dichlorobenzyl alcohol, 35% 1,3-propanediol, 5% sodium cocamidopropyl PG-dimethyl phosphate, and the balance being deionized water.

[0048] Comparative Example 1 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 2% Melaleuca alternifolia extract, 8% Magnolia officinalis bark extract, 6% Dictamnus dasycarpus root bark extract, 0.5% sorbitan caprylate, 3% dichlorobenzyl alcohol, 35% 1,3-propanediol, 3% sodium cocamidopropyl PG-dimethyl phosphate, and the balance being deionized water.

[0049] Comparative Example 2 The difference from Example 1 is that the Dictamnus dasycarpus root bark extract in the composition is replaced with an equal percentage by mass of deionized water.

[0050] Comparative Example 3 The difference from Example 1 is that the Magnolia officinalis bark extract in the composition is replaced with an equal percentage by mass of deionized water.

[0051] Comparative Example 4 The difference from Example 1 is that 1,3-propanediol in the composition is replaced with 1,2-propanediol in equal mass percentage.

[0052] Comparative Example 5 Compared with Example 1, the difference lies in the composition of the composition, which is as follows: 5% Melaleuca alternifolia leaf extract, 7% Platycladus orientalis leaf extract (deionized water extract), 5% Rosemary extract (ethanol extract), 3% Magnolia officinalis bark extract, 0.5% sorbitan caprylate, 2% dichlorobenzyl alcohol, 40% 1,3-propanediol, 8% sodium cocamidopropyl PG-dimethyl phosphate, and the balance being deionized water.

[0053] Test case (1) In vitro inhibition rate of Malassezia in 24h: using the perforated agar diffusion method, Malassezia culture medium was prepared, and the sample to be tested was added in equal amounts. After culturing for 24h, the diameter of the inhibition zone was measured and the inhibition rate was calculated.

[0054] (2) Dandruff removal and recurrence test: A gray scale method was used to measure the gray area of ​​the scalp in a uniform area. The dandruff area was statistically analyzed at the baseline. The removal rate was statistically analyzed after 7 days of continuous use, and the recurrence area percentage was statistically analyzed after 15 days of discontinuation.

[0055] (3) Storage stability test: Placed at high temperature of 50℃ and low temperature of -15℃ for 30 days respectively, and the layering and color change were observed.

[0056] The test results are shown in the table below.

[0057]

[0058] As can be seen from the table above: As can be seen from the examples and Comparative Example 1, after removing oil-controlling and antipruritic components such as Platycladus orientalis leaf extract and rosemary extract from the composition of the present invention, the specific anti-dandruff effect can be obtained by using Melaleuca alternifolia leaf extract, Magnolia officinalis bark extract, Dictamnus dasycarpus root bark extract, sorbitan caprylate, dichlorobenzyl alcohol and 1,3-propanediol, which effectively improves the anti-dandruff effect of the composition.

[0059] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0060] For those skilled in the art, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. An anti-dandruff composition, characterized in that, It consists of the following components in the indicated mass percentages: Melaleuca alternifolia extract: 3%~6% Magnolia officinalis bark extract: 2%~5% Dictamnus dasycarpus root bark extract: 1%~4% Sorbitan octanoate: 0.5%~2%, Dichlorobenzyl alcohol: 1%~3%, 1,3-Propanediol: 35%~50% Sodium cocamidopropyl PG-dimethyl phosphate: 5%~10% Deionized water: Balance.

2. The anti-dandruff composition according to claim 1, characterized in that, The mass ratio of the Melaleuca alternifolia extract to the Magnolia officinalis bark extract is (1.5~2.5):

1.

3. The anti-dandruff composition according to claim 1, characterized in that, The mass ratio of the Melaleuca alternifolia extract to the Dictamnus dasycarpus root bark extract is (2.8~3.5):

1.

4. The anti-dandruff composition according to claim 1, characterized in that, The mass ratio of sorbitan octanoate to dichlorobenzyl alcohol is (0.5~1):

1.

5. The anti-dandruff composition according to any one of claims 1 to 4, characterized in that, The preparation method of the Melaleuca alternifolia extract is as follows: Take dried branches and leaves of Melaleuca alternifolia, crush them, and pass them through a 10-20 mesh sieve; Extracting volatile oils by steam distillation: The crushed raw material is put into a distillation vessel, 6 to 8 times the amount of deionized water is added, the mixture is heated to boiling and maintained for 1.5 to 2.5 hours, and the distillate is collected. The distillate is separated into oil and water, and the upper layer of essential oil is collected for later use. After distillation, the solid phase is drained, and 8-10 times the volume of 50-70% ethanol is added. The mixture is then extracted by hot reflux at 60-70℃ for 1-1.5 hours. The extraction is repeated 2-3 times. The extracts are combined, filtered, and the ethanol is concentrated to obtain an alcohol extract with a relative density of 1.05-1.

1. The extract was mixed with the upper essential oil to obtain Melaleuca alternifolia extract.

6. The anti-dandruff composition according to any one of claims 1 to 4, characterized in that, The preparation method of the Magnolia officinalis bark extract is as follows: Take dried Magnolia officinalis bark, crush it and pass it through a 10-20 mesh sieve. Add 8-12 times the amount of 75-85% ethanol (by volume) and extract it by hot reflux at 70-80℃ for 1.5-2 hours. Repeat the extraction 2-3 times. Combine the extracts, filter them, concentrate and recover the ethanol to obtain the extract. Purification was performed using macroporous adsorption resin: The extract was diluted with water and loaded onto an AB-8 macroporous adsorption resin column. It was first washed with deionized water until the eluent was colorless, and then eluted with 60-80% ethanol by volume. The eluent was collected, concentrated under reduced pressure, dried, and pulverized to obtain the Magnolia officinalis bark extract.

7. The anti-dandruff composition according to any one of claims 1 to 4, characterized in that, The preparation method of the Dictamnus dasycarpus root bark extract is as follows: Take dried Dictamnus dasycarpus root bark, crush it and pass it through a 20-40 mesh sieve. Add 10-15 times the amount of 70-80% ethanol by volume, and extract it by hot reflux at 60-70℃ for 1-1.5 hours. Repeat the extraction 2-3 times, combine the extracts, filter, concentrate and recover the ethanol to obtain the extract. After dispersing the extract in water, extract it 2-3 times with ethyl acetate, combine the ethyl acetate phases, recover the solvent under reduced pressure until dry, and pulverize to obtain the extract of Dictamnus dasycarpus root bark.

8. A method for preparing an anti-dandruff composition according to any one of claims 1 to 7, characterized in that, Includes the following steps: S1: Under light-protected conditions, heat 1,3-propanediol to 45~50℃, add Melaleuca alternifolia extract, Magnolia officinalis bark extract and Dictamnus dasycarpus root bark extract, stir to dissolve, stirring speed is 300~500 rpm, stirring time is 20~30 min; S2: Add deionized water to the mixture obtained in step S1 and cool it to 35~40℃; S3: Add sorbitan octanoate and dichlorobenzyl alcohol, and stir until well mixed.

9. An anti-dandruff shampoo, characterized in that, The dandruff composition comprising any one of claims 1 to 7, wherein the dandruff composition comprises 1% to 5% of the total mass of the dandruff shampoo.

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