A dual dosage form oral liquid and honeyed pill containing ginseng, astragalus and ficus pumila, and a low-temperature preservation preparation process thereof

Abstract

The application discloses a Yiqi Yangxue double-dosage oral liquid and honeyed pill containing ginseng, radix astragali and fici fructus and a low-temperature preparation process thereof, relates to the technical field of health-care product manufacturing, and aims to solve the technical problems that current Bazhen preparations are often single in prescription structure, limited in applicable population, and single in dosage form, and it is difficult to balance the instant effect and long-term conditioning, and comprises a double-dosage preparation, which is any one of an oral liquid and a honeyed pill. The application adds fici fructus for invigorating the spleen and eliminating dampness, radix astragali for benefiting qi and consolidating the exterior, and resolves the properties of rehmannia glutinosa and angelica sinensis for nourishing and greasy, and solves the problems of abdominal distension, excessive phlegm and aggravated dampness after taking traditional Bazhen. Ginseng and radix astragali are combined, the ability of consolidating the exterior and strengthening the body resistance is greatly enhanced, and the double-dosage preparation has remarkable curative effect on people with long-term fatigue, qi deficiency and easy sweating, and low immunity, the oral liquid has rapid effect and short-term relief of fatigue, dizziness and heavy body, the low-temperature honeyed pill has slow release and long-term effect, continuously invigorates the spleen, nourishes the blood and consolidates the body, one rapid and one slow, and the preparation synchronously regulates the symptoms and root causes, and overcomes the short board of curative effect of single dosage form.

Description

Technical Field

[0001] This invention relates to the field of health product manufacturing technology, and more specifically, to a dual-form oral liquid and honey pill containing ginseng, astragalus, and five-finger peach, which invigorates qi and nourishes blood, and its low-temperature efficacy preservation preparation process. Background Technology

[0002] Bazhen Decoction is a classic formula for replenishing both Qi and Blood, passed down for thousands of years. The standard formula consists of eight herbs: ginseng, stir-fried Atractylodes macrocephala, Poria cocos, licorice root, Angelica sinensis, white peony root, prepared Rehmannia glutinosa, and Ligusticum chuanxiong. Its core function is solely to replenish Qi and Blood, and it is clinically used for simple Qi and Blood deficiency syndromes. Currently available marketed preparations based on Bazhen Decoction mainly include Bazhen Oral Liquid, Bazhen Pills, Bazhen Honey Pills, and Bazhen Granules, all using the traditional eight-herb formula.

[0003] The existing general production system for Bazhen preparations involves mixing and decocting all medicinal materials at high temperature, concentrating at normal pressure and high temperature, refining honey at high temperature to form pills, drying at constant temperature and high temperature, and sterilizing at high temperature and high pressure. The supporting equipment includes conventional high-temperature extraction tanks, normal pressure concentrators, high-temperature honey refining machines, ordinary drying ovens, and conventional filling equipment.

[0004] However, existing Bazhen (Eight Treasures) preparations often have a simple formulation, making them unsuitable for modern individuals with dampness and deficiency, limiting their applicability to certain populations. Furthermore, their single dosage form makes it difficult to achieve both rapid and long-term effects. Single oral liquids have a fast onset of action but a short duration, lacking fat-soluble and volatile components; single honey pills have a slow onset of action and are insufficient to quickly relieve acute symptoms of weakness such as fatigue and palpitations. Therefore, we propose a dual-form oral liquid and honey pill containing ginseng, astragalus, and five-finger peach, for invigorating qi and nourishing blood, along with their low-temperature preservation preparation process. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art, adapt to the needs of reality, and provide a dual-form oral liquid and honey pill containing ginseng, astragalus, and five-finger peach for invigorating qi and nourishing blood, as well as its low-temperature efficacy preservation preparation process, in order to solve the technical problems that current Bazhen preparations often have a single formulation structure, limited applicable population, and single dosage form, making it difficult to achieve both rapid effect and long-term conditioning.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a dual-dosage oral liquid and honey pills containing ginseng, astragalus, and five-finger peach, comprising a dual-dosage formulation, wherein the dual-dosage formulation is either an oral liquid or honey pills, and the dual-dosage formulation is composed of the following components in parts by weight: Licorice 3-5 parts; Ficus hirta 3-5 parts; Ginseng 5-7 parts; Atractylodes macrocephala (fried) 8-10 parts; Poria cocos 8-10 parts; Angelica sinensis 8-10 parts; Ligusticum chuanxiong 5-7 parts; Paeonia lactiflora 8-10 parts; Rehmannia glutinosa (processed) 11-13 parts; Astragalus membranaceus 7-9 parts.

[0007] Preferably, the two-dosage formulation comprises the following components in parts by weight: Licorice 4 parts; Ficus hirta 4 parts; Ginseng 6 parts; Atractylodes macrocephala (fried) 9 parts; Poria cocos 9 parts; Angelica sinensis 9 parts; Ligusticum chuanxiong 6 parts; Paeonia lactiflora 9 parts; Rehmannia glutinosa (processed) 12 parts; Astragalus membranaceus 8 parts.

[0008] Preferably, the compatibility relationship of the two-dosage formulation is as follows: The principal herbs are ginseng and astragalus, which are used to greatly replenish vital energy, strengthen the exterior, and combat fatigue. The accompanying herbs are Rehmannia glutinosa (processed), Angelica sinensis, Paeonia lactiflora, and Ligusticum chuanxiong, used to nourish and regulate blood, and replenish yin and blood. The adjuvant herbs are five-finger peach, stir-fried atractylodes macrocephala, and poria cocos, which are used to strengthen the spleen, remove dampness, and resolve the greasiness of nourishing and tonifying herbs. The herb used is licorice, which is used to harmonize the effects of other herbs.

[0009] Preferably, the weight ratio of licorice to five-finger peach is 1:1, and the weight ratio of ginseng to astragalus is (5-7):(7-9).

[0010] Preferably, the oral liquid is used to quickly improve symptoms of physical weakness, and the honey pills are used for long-term spleen-strengthening and blood-nourishing conditioning.

[0011] Preferably, the oral liquid is prepared from the water-soluble active ingredient of the composition, and the honey pill is prepared from the fat-soluble active ingredient, volatile oil and ultrafine powder of the composition.

[0012] A low-temperature efficacy-preserving preparation process for a dual-dosage oral liquid containing ginseng, astragalus, and five-finger peach, characterized by the following steps: S1. Coarsely crushed after washing: The medicinal materials in the specified weight parts are sorted and impurities are removed. After being sprayed and washed, they are drained until the moisture content is 10% to 15%, and then crushed into coarse powder of 20 to 30 mesh. S2. Low-temperature extraction: The crude powder is subjected to three-stage low-temperature constant-temperature reflux extraction, with the extraction temperature controlled at 70-78℃: First, 8-10 times the weight of purified water is added, soaked at 75℃ for 30 minutes, and then refluxed at 78℃ for 60 minutes, and the extract is filtered out; Second, 6-8 times the weight of purified water is added to the residue, and refluxed at 75℃ for 45 minutes, and the extract is collected; Third, 4-5 times the weight of purified water is added to the residue, and refluxed at 70℃ for 30 minutes; The three extracts are combined, and the residue is filtered out to obtain the crude extract; S3. Concentration and Filtration of Drug Solution: The crude extract is concentrated under reduced pressure at a vacuum of -0.07 to -0.09 MPa and a temperature of 75 to 78°C to a paste with a relative density of 1.10 to 1.15 at 60°C; the paste is first coarsely filtered through a 100-mesh filter and then finely filtered through a 0.22 μm microporous membrane to obtain a clear and purified drug solution; S4. Flavor adjustment and sterilization: Add 5% to 8% of the total weight of the purified drug solution to honey and 2% to 3% of xylitol. Stir and mix at 45 to 50°C, then homogenize at 48°C under low pressure for 15 minutes. After homogenization, pasteurize the drug solution at 80°C for 15 minutes, aseptically fill it, and let it stand at room temperature for 24 hours to obtain the oral liquid.

[0013] Preferably, the preparation method employs a series of components arranged in sequence along the process: a medicinal material pretreatment unit, a low-temperature three-stage reflux extraction unit, a low-temperature vacuum concentration and purification unit, a low-temperature homogenization and blending unit, and a low-temperature pasteurization and aseptic filling unit. Each unit is connected in a sealed manner through insulated conveying pipelines, conveying pumps, and control valves, and the material is conveyed under closed negative pressure throughout the process, with the material temperature not exceeding 80°C throughout the process.

[0014] Preferably, each unit is equipped with a PLC temperature control cabinet, a temperature probe and a pressure sensor, and each conveying pipe and tank is covered with a heat insulation layer.

[0015] A low-temperature efficacy-preserving preparation process for a dual-dosage honey pill containing ginseng, astragalus, and five-finger peach, characterized by the following steps: T1. After washing, the herbs are finely ground: the herbs in the specified weight proportions are sorted and impurities are removed, they are sprayed and washed, drained, mixed and then ground at low temperature into 120-mesh fine powder. T2. Mixing and pill making: Refining locust honey at a low temperature of 55-60℃, mixing it with the fine medicinal powder to form a soft material, and making pills to obtain wet honey pills; T3. Low-temperature drying and sterilization: The wet honey pills are subjected to three-stage gradient low-temperature drying: pre-drying at 40℃ for 1 hour, constant temperature drying at 50℃ for 2 hours, and shaping drying at 55℃ for 1 hour; after drying, they are filled and sterilized by low-temperature irradiation to obtain the honey pills.

[0016] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention addresses the issues of abdominal distension, excessive phlegm, and worsening dampness after taking traditional Bazhen Decoction by adding five-finger peach to strengthen the spleen and remove dampness, and astragalus to invigorate qi and consolidate the exterior, thus mitigating the cloying nature of rehmannia and angelica. The combination of ginseng and astragalus significantly enhances the ability to consolidate the exterior and strengthen the body, making it highly effective for people with chronic fatigue, qi deficiency and easy sweating, and low immunity. The oral liquid has a rapid onset of action, providing short-term relief for fatigue, dizziness, and heaviness of the body. The low-temperature honey pill has a slow-release and long-lasting effect, continuously strengthening the spleen, nourishing blood, and consolidating the body's foundation. The combination of rapid and slow action addresses both the symptoms and the root cause, overcoming the shortcomings of single dosage forms.

[0017] 2. This invention uses a low-temperature process throughout the entire process to lock in the viability of active ingredients, processing at ≤80℃ throughout. This process fully preserves the volatile oils of Angelica sinensis and Ligusticum chuanxiong, ginsenosides, astragaloside A, and flavonoids from Ficus hirta. The retention rate of effective ingredients is more than 30% higher than that of traditional high-temperature preparations. The medicinal liquid is clear and transparent, and there is no sedimentation or layering even after long-term storage. The combination of honey and xylitol balances the bitterness, making it palatable and eliminating the need for additional preservatives. The low-temperature honey refining process avoids caramelization and heat, and does not cause internal heat even after long-term use. The three-stage gradient drying process ensures uniform moisture content inside and outside the pills, preventing cracking, dampness, and mold, and significantly extending the shelf life. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the production process of the oral liquid of the present invention; Figure 2 This is a schematic diagram of the production process of the honey pills of the present invention. Detailed Implementation

[0019] The present invention relates to a dual-form oral liquid and honey pill containing ginseng, astragalus, and five-finger peach, which invigorates qi and nourishes blood, comprising: 4g licorice, 4g five-finger peach, 6g ginseng, 9g stir-fried atractylodes macrocephala, 9g poria cocos, 9g angelica sinensis, 6g chuanxiong rhizome, 9g white peony root, 12g prepared rehmannia root, and 8g astragalus. This invention introduces a novel ten-ingredient compound formula by unconventionally adding two unique herbs, *Ficus hirta* and *Astragalus membranaceus*, to the traditional eight-ingredient formula. It employs a novel formulation structure: the principal herbs are ginseng and astragalus, working together to significantly replenish vital energy, strengthen the exterior, and combat fatigue; the assistant herbs are rehmannia glutinosa, angelica sinensis, white peony root, and chuanxiong rhizome, which nourish and harmonize blood, replenishing yin and blood; the adjuvant herbs are *Ficus hirta*, stir-fried atractylodes macrocephala, and poria cocos, which strengthen the spleen, dispel dampness, and neutralize the cloying richness of the tonics; and the guiding herb is licorice root (in a low dose), which harmonizes the other herbs, benefiting qi without causing stagnation. The overall treatment principle is upgraded from a simple "dual replenishment of qi and blood" to a three-dimensional approach of "strengthening the exterior and replenishing qi, strengthening the spleen and dispelling dampness, and nourishing blood and consolidating the foundation."

[0020] This invention avoids the drawbacks of high-dose licorice (3-5g) causing water retention and spleen stagnation by using a low dose of licorice; it also uses a fixed dose of 3-5g of five-finger peach to gently remove dampness without harming yin, making it suitable for long-term conditioning; it combines 6g of ginseng with 7-9g of astragalus to form a golden ratio for replenishing qi, replenishing qi without causing dryness and heat; and it uses 11-13g of prepared rehmannia root to quantitatively nourish yin, replenishing blood without causing greasiness or dampness.

[0021] This formula can simultaneously improve sallow complexion, relieve physical weakness and fatigue, eliminate heaviness in the body, reduce susceptibility to spontaneous sweating, and regulate spleen deficiency and phlegm dampness. Furthermore, long-term use does not cause side effects such as internal heat, abdominal distension, or edema, achieving a combined therapeutic effect that traditional formulas could not. It is specifically designed for modern populations suffering from qi deficiency and dampness-induced sub-health, fatigue from staying up late, postpartum weakness, postoperative qi and blood deficiency, spleen deficiency with excessive phlegm, low immunity, and spontaneous sweating. It expands the applicability of traditional Bazhen formulas, creating entirely new medical applications.

[0022] like Figures 1 to 2As shown, the present invention relates to a low-temperature efficacy-preserving preparation process for a dual-form oral liquid and honey pill containing ginseng, astragalus, and five-finger peach, which invigorates qi and nourishes blood, including the following steps: The temperature during the entire extraction, concentration, and sterilization process does not exceed 80℃. The complete steps are as follows: 1. Pretreatment of medicinal materials All medicinal materials are sorted and impurities are removed, then quickly rinsed with clean water and air-dried until the moisture content is 10%; 20-mesh coarse powder.

[0023] 2. Three-stage low-temperature isothermal reflux extraction The extraction temperature was controlled at 70℃, and extraction was performed in stages using a gradient water addition method. ① First extraction: Add 8 times the amount of purified water to the mixed medicinal materials, soak at 75℃ for 30 minutes, reflux at 78℃ for 60 minutes, and filter out the extract; ② Second extraction: Add 6 times the volume of purified water to the residue, reflux at 75℃ for 45 min, and collect the liquid; ③ Third extraction: Add 4 times the amount of purified water to the residue and reflux at 70℃ for 30 minutes; The three extracts were combined, and the residue was filtered out to obtain a crude extract.

[0024] 3. Low-temperature vacuum concentration and fractionation purification The crude extract was fed into a vacuum concentration device with a vacuum degree of -0.07 MPa and a concentration temperature of 75°C, and concentrated to a relative density of 1.10 at 60°C. First, the solution is coarsely filtered through a 100-mesh filter, and then finely filtered through a 0.22μm microporous membrane to remove macromolecular impurities and suspended solids, resulting in a clear and purified drug solution.

[0025] 4. Prepare low-temperature homogenizer Add 5% honey and 2% xylitol by weight of the purified drug solution as flavoring agents, and stir at low temperature and low speed at 45℃ until well mixed. The sample is fed into a homogenizer and homogenized at low pressure at 48°C for 15 minutes to ensure uniform dispersion of the active ingredients and prevent stratification during storage.

[0026] 5. Low-temperature pasteurization, aseptic filling, and ripening. After homogenization, the drug solution is pasteurized at 80℃ and kept at a constant temperature for 15 minutes to kill microorganisms without destroying the heat-sensitive active ingredients. The product is quantitatively filled and sealed in a sterile clean workshop; it is then left to mature in a cool, shady place at room temperature for 24 hours. Once it passes quality inspection, it becomes the finished product, a qi-nourishing and blood-tonifying oral liquid.

[0027] 6. Preparation of Low-Temperature Preservative Honey Pills All raw materials are not extracted. All raw materials are thoroughly mixed and pulverized at low temperature into fine powder, which is then pulverized to 120 mesh for later use. Locust honey is refined at 55℃ and kneaded with the medicinal materials to form a soft material. The material is then automatically made into pills and dried in three stages at low temperature (pre-drying at 40℃ for 1 hour, constant temperature at 50℃ for 2 hours, and setting at 55℃ for 1 hour). After bottling, the product is sterilized by low-temperature irradiation and becomes the finished product that nourishes qi and blood.

[0028] 7. Two-dosage combination packaging The oral liquid is designed to quickly improve fatigue, shortness of breath, and general heaviness; the low-temperature honey pills provide long-lasting benefits by strengthening the spleen, nourishing blood, and regulating the body. Together, they achieve a comprehensive treatment that addresses both the symptoms and the root cause.

[0029] This invention employs an extraction temperature range of 70–78°C, a concentration temperature of 75–78°C, and a sterilization temperature of 80°C, all at temperatures lower than traditional boiling. This significantly improves the retention rate of Astragalus polysaccharides and flavonoids from Prunus cerasifera. The three-stage gradient extraction enhances raw material utilization, while microporous filtration and low-temperature homogenization ensure long-term clarity of the medicinal liquid. Low-temperature pasteurization replaces high-temperature instantaneous sterilization, preventing component charring and ensuring stable color of the medicinal liquid.

[0030] The ten medicinal materials are divided into four categories according to their component characteristics. They can be extracted at low temperatures in separate streams. Water-soluble and fast-acting components are used in oral liquids, while fat-soluble, volatile oils, and ultrafine powders are used in honey pills. The characteristics of the formula components are highly compatible with the low-temperature dual-dosage form process, forming an innovative integrated solution of formula + dosage form + process.

[0031] The process of this invention also includes the following oral liquid preparation equipment: This complete set of equipment for preparing low-temperature oral liquid is arranged in series along the production process. It is mainly divided into five units: a medicinal material pretreatment unit, a low-temperature three-stage reflux extraction unit, a low-temperature vacuum concentration and purification unit, a low-temperature homogenization and preparation unit, and a low-temperature pasteurization and aseptic filling unit. Each unit is connected to the other by conveying pipelines, pumps, control valves, and buffer tanks in a sealed manner. The entire process is carried out under closed negative pressure to avoid oxidation of the liquid when exposed to air and high-temperature rise, thus achieving continuous low-temperature production.

[0032] Pre-processing equipment includes sorting and washing machines, hot air low-temperature dewatering silos, crushers, powder temporary storage silos, and screw conveyors; The low-temperature extraction equipment includes a three-stage series low-temperature reflux extraction tank, a circulating hot water constant temperature heat exchanger, a liquid delivery centrifugal pump, a residue discharge valve, and a filter screen assembly. The concentration and purification equipment includes a low-temperature vacuum concentration tank, a vacuum unit, a cooling and condensing device, a 100-mesh coarse filter, a 0.22μm microporous membrane fine filter unit, and an intermediate buffer tank; The homogenization and blending equipment includes a low-temperature blending and mixing tank, a dual-control heat exchange jacket for hot and cold water, a honey / xylitol auxiliary material metering and feeding device, a low-pressure homogenizer, and a circulating mixing pump; Sterilization and filling equipment includes low-temperature pasteurization insulated tanks, aseptic clean pipelines, automatic quantitative filling machines, sealing machines, and finished product maturation and temporary storage silos; The supporting control accessories include a PLC temperature control cabinet, pressure sensor, temperature probe, vacuum pressure gauge, pneumatic shut-off valve, and insulated conveying pipeline.

[0033] The process of this invention also includes the following honey pill preparation equipment: This includes a raw material washing and drying machine, a low-temperature pulverizer, a low-temperature honey refining and medicine mixing machine, a fully automatic pill making machine, a three-stage gradient low-temperature drying oven, a dust-free automatic honey pill filling machine, and a low-temperature irradiation sterilization channel. The raw materials are fed into the raw material washing and drying machine, and the output is connected to the low temperature pulverizer. The fine powder output is connected to the low temperature honey refining and medicine mixing machine. The mixed medicine soft material is fed into the fully automatic pill making machine. The produced wet pills are conveyed into the three-stage gradient low temperature drying box in sequence, and then transferred to the honey pill dust-free automatic filling machine for packaging. Finally, the product is sent into the low temperature irradiation sterilization channel.

[0034] The embodiments disclosed in this invention are preferred embodiments, but are not limited thereto. Those skilled in the art can easily understand the spirit of this invention based on the above embodiments and make different extensions and variations, but as long as they do not depart from the spirit of this invention, they are all within the protection scope of this invention.

Claims

1. A dual-form oral liquid and honey pill containing ginseng, astragalus, and five-finger peach, characterized in that... This includes a two-dosage formulation, wherein the two-dosage formulation is either an oral liquid or a honey pill, and the two-dosage formulation is composed of the following components in parts by weight: Licorice 3-5 parts; Ficus hirta 3-5 parts; Ginseng 5-7 parts; Atractylodes macrocephala (fried) 8-10 parts; Poria cocos 8-10 parts; Angelica sinensis 8-10 parts; Ligusticum chuanxiong 5-7 parts; Paeonia lactiflora 8-10 parts; Rehmannia glutinosa (processed) 11-13 parts; Astragalus membranaceus 7-9 parts.

2. The oral liquid and honey pills containing ginseng, astragalus, and five-finger peach as described in claim 1, characterized in that, The two-dosage formulation comprises the following components in parts by weight: Licorice 4 parts; Ficus hirta 4 parts; Ginseng 6 parts; Atractylodes macrocephala (fried) 9 parts; Poria cocos 9 parts; Angelica sinensis 9 parts; Ligusticum chuanxiong 6 parts; Paeonia lactiflora 9 parts; Rehmannia glutinosa (processed) 12 parts; Astragalus membranaceus 8 parts.

3. The oral liquid and honey pills containing ginseng, astragalus, and five-finger peach as described in claim 1, characterized in that... The compatibility relationship of the two-dosage formulation is as follows: The principal herbs are ginseng and astragalus, which are used to greatly replenish vital energy, strengthen the exterior, and combat fatigue. The accompanying herbs are Rehmannia glutinosa (processed), Angelica sinensis, Paeonia lactiflora, and Ligusticum chuanxiong, used to nourish and regulate blood, and replenish yin and blood. The adjuvant herbs are five-finger peach, stir-fried atractylodes macrocephala, and poria cocos, which are used to strengthen the spleen, remove dampness, and resolve the greasiness of nourishing and tonifying herbs. The herb used is licorice, which is used to harmonize the effects of other herbs.

4. The oral liquid and honey pills containing ginseng, astragalus, and five-finger peach as described in claim 1, characterized in that, The weight ratio of licorice to five-finger peach is 1:1, and the weight ratio of ginseng to astragalus is (5-7):(7-9).

5. The oral liquid and honey pills containing ginseng, astragalus, and five-finger peach as described in claim 1, characterized in that, The oral liquid is used to quickly improve symptoms of physical weakness, while the honey pills are used for long-term spleen-strengthening and blood-nourishing conditioning.

6. The oral liquid and honey pills containing ginseng, astragalus, and five-finger peach as described in claim 5, characterized in that, The oral liquid is prepared from the water-soluble active ingredients of the composition, and the honey pills are prepared from the fat-soluble active ingredients, volatile oils, and ultrafine powders of the composition.

7. A low-temperature efficacy-preserving preparation process for a dual-dose oral liquid containing ginseng, astragalus, and five-finger peach, which is applicable to the dual-dose oral liquid containing ginseng, astragalus, and five-finger peach as described in any one of claims 1-6, characterized in that... Includes the following steps: S1. Coarsely crushed after washing: The medicinal materials in the specified weight parts are sorted and impurities are removed. After being sprayed and washed, they are drained until the moisture content is 10% to 15%, and then crushed into coarse powder of 20 to 30 mesh. S2. Low-temperature extraction: The crude powder is subjected to three-stage low-temperature constant-temperature reflux extraction, with the extraction temperature controlled at 70-78℃: First, 8-10 times the weight of purified water is added, soaked at 75℃ for 30 minutes, and then refluxed at 78℃ for 60 minutes, and the extract is filtered out; Second, 6-8 times the weight of purified water is added to the residue, and refluxed at 75℃ for 45 minutes, and the extract is collected; Third, 4-5 times the weight of purified water is added to the residue, and refluxed at 70℃ for 30 minutes; The three extracts are combined, and the residue is filtered out to obtain the crude extract; S3. Concentration and Filtration of Drug Solution: The crude extract is concentrated under reduced pressure at a vacuum of -0.07 to -0.09 MPa and a temperature of 75 to 78°C to a paste with a relative density of 1.10 to 1.15 at 60°C; the paste is first coarsely filtered through a 100-mesh filter and then finely filtered through a 0.22 μm microporous membrane to obtain a clear and purified drug solution; S4. Flavor adjustment and sterilization: Add 5% to 8% of the total weight of the purified drug solution to honey and 2% to 3% of xylitol. Stir and mix at 45 to 50°C, then homogenize at 48°C under low pressure for 15 minutes. After homogenization, pasteurize the drug solution at 80°C for 15 minutes, aseptically fill it, and let it stand at room temperature for 24 hours to obtain the oral liquid.

8. The low-temperature efficacy preservation preparation process of a dual-dosage oral liquid containing ginseng, astragalus, and five-finger peach as described in claim 7, characterized in that, The preparation method employs a series of components arranged in sequence: a medicinal material pretreatment unit, a low-temperature three-stage reflux extraction unit, a low-temperature vacuum concentration and purification unit, a low-temperature homogenization and blending unit, and a low-temperature pasteurization and aseptic filling unit. Each unit is connected in a sealed manner through insulated conveying pipelines, conveying pumps, and control valves. The material is conveyed under closed negative pressure throughout the entire process, and the material temperature does not exceed 80°C.

9. The low-temperature efficacy preservation preparation process of a dual-dosage oral liquid containing ginseng, astragalus, and five-finger peach as described in claim 8, characterized in that, Each unit is equipped with a PLC temperature control cabinet, temperature probe and pressure sensor, and each conveying pipeline and tank is covered with a heat insulation layer.

10. A low-temperature efficacy-preserving preparation process for a dual-action honey pill containing ginseng, astragalus, and five-finger peach, which is applicable to the dual-action honey pill containing ginseng, astragalus, and five-finger peach as described in any one of claims 1-6, characterized in that... Includes the following steps: T1. After washing, the herbs are finely ground: the herbs in the specified weight proportions are sorted and impurities are removed, they are sprayed and washed, drained, mixed and then ground at low temperature into 120-mesh fine powder. T2. Mixing and pill making: Refining locust honey at a low temperature of 55-60℃, mixing it with the fine medicinal powder to form a soft material, and making pills to obtain wet honey pills; T3. Low-temperature drying and sterilization: The wet honey pills are subjected to three-stage gradient low-temperature drying: pre-drying at 40℃ for 1 hour, constant temperature drying at 50℃ for 2 hours, and shaping drying at 55℃ for 1 hour; after drying, they are filled and sterilized by low-temperature irradiation to obtain the honey pills.

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