A traditional Chinese medicine preparation for postoperative recovery of thyroid cancer and a preparation method thereof

Abstract

The application provides a traditional Chinese medicine preparation for postoperative recovery of thyroid cancer and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from Prunella vulgaris, Rhoalopsidaceae, Fritillaria thunbergii Miq., Giant Knotweed, Malpighia glabra, Acroloxia, Crossostephus chinensis, Pseudostellaria heterophylla, Dendrobium, Radix Paeoniae Alba, Solanum nigrum L., Fructus Corni, Meaglospermae and Radix Glycyrrhizae. The traditional Chinese medicine composition can significantly improve the general deficiency state of the model rats after total thyroidectomy, effectively regulate the postoperative thyroid hormone disorder, reverse the postoperative immunosuppression state, improve the overall survival state and local postoperative injury of the model rats. The clinical research proves that the preparation can effectively reduce the incidence of postoperative complications, improve the neck and shoulder movement function of the patients, improve the deficiency and stagnation syndromes of traditional Chinese medicine, relieve the postoperative depression and anxiety emotions, and comprehensively improve the postoperative rehabilitation level and life quality of tumors. In conclusion, the traditional Chinese medicine preparation is safe and reliable, has definite curative effect, and has good clinical application value for the postoperative recovery of thyroid cancer.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine pharmaceutical technology, specifically to a traditional Chinese medicine preparation for postoperative recovery of thyroid cancer and its preparation method. Background Technology

[0002] Thyroid cancer is a common malignant tumor of the endocrine system and head and neck, mainly including pathological types such as papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma, with papillary thyroid carcinoma being the most common. Currently, the core clinical treatment for thyroid cancer is surgical resection, supplemented by postoperative radioactive iodine therapy, endocrine suppression therapy, and other comprehensive interventions. This can effectively remove lesions, control disease progression, and prolong patient survival. However, surgical trauma and subsequent adjuvant therapies can easily cause multidimensional damage to the body, inducing a series of short-term and long-term postoperative complications, seriously hindering the patient's postoperative recovery process and affecting their physical and mental state and quality of life.

[0003] Postoperative complications after thyroid cancer surgery are common and varied. Intraoperative traction of neck anatomical tissues, nerve and parathyroid gland damage can easily lead to hypocalcemia, numbness of the limbs and lips, hoarseness, choking while drinking, and other neuroendocrine damage symptoms. Simultaneously, poor wound healing, local swelling, subcutaneous hematoma, and wound infection may occur. These complications not only prolong hospital stays and increase the financial burden on healthcare providers, but also cause limited neck and shoulder mobility and persistent physical discomfort, severely impacting postoperative recovery efficiency and long-term quality of life.

[0004] Traditional Chinese medicine (TCM) possesses unique advantages in the field of postoperative rehabilitation for malignant tumors, including holistic conditioning, addressing both the root cause and symptoms, minimal side effects, and multi-target intervention. It can effectively address the complex pathogenesis of thyroid cancer postoperatively, characterized by multiple symptoms and organ dysfunction. TCM theory posits that thyroid cancer falls under the category of "goiter," with its pathogenesis stemming from surgical trauma depleting qi and blood, damaging the body's vital energy, coupled with intraoperative blood stasis and emotional distress, leading to qi and blood deficiency, liver qi stagnation, phlegm and blood stasis accumulation, and organ dysfunction. This results in symptoms such as general weakness, shortness of breath, spontaneous sweating, dry mouth and throat, and localized swelling and pain. Currently, most traditional Chinese medicine (TCM) formulas for post-operative care of thyroid cancer patients are general-purpose formulas that regulate qi and disperse stagnation, and replenish qi and blood. These formulas lack specificity and fail to address the unique post-operative pathogenesis of thyroid cancer, which includes qi deficiency, phlegm and blood stasis, and lingering toxins. Consequently, they suffer from imprecise formulation, limited efficacy, and slow onset of action, making it difficult to simultaneously address the multiple post-operative recovery needs such as tonifying qi and strengthening the body, resolving phlegm and dispersing stagnation, clearing meridian stagnation, and calming the mind and spirit. Therefore, developing a TCM preparation with a rigorous formulation, definite efficacy, high safety, and targeted at the core pathogenesis of thyroid cancer post-operatively is of significant clinical importance and has broad application prospects for improving the quality of life and promoting post-operative recovery in thyroid cancer patients. Summary of the Invention

[0005] (a) Technical problems to be solved

[0006] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine preparation for postoperative recovery after thyroid cancer surgery and its preparation method.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] In a first aspect, the present invention provides a traditional Chinese medicine preparation for postoperative recovery of thyroid cancer, the preparation being made from the following raw materials in parts by weight: 8-30 parts of Prunella vulgaris, 12-32 parts of Hedyotis diffusa, 12-32 parts of Fritillaria thunbergii, 10-30 parts of Polygonum cuspidatum, 8-30 parts of Polygonum hydropiper, 8-30 parts of Spatholobus suberectus, 5-25 parts of Physalis alkekengi, 5-25 parts of Pseudostellaria heterophylla, 4-20 parts of Dendrobium nobile, 4-20 parts of Paeonia lactiflora, 3-12 parts of Solanum nigrum, 3-20 parts of Cornus officinalis, 3-18 parts of Prunus mume, and 3-12 parts of Glycyrrhiza uralensis.

[0010] Preferably, the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 12-24 parts of Prunella vulgaris, 18-28 parts of Hedyotis diffusa, 18-28 parts of Fritillaria thunbergii, 15-25 parts of Polygonum cuspidatum, 12-24 parts of Polygonum hydropiper, 12-24 parts of Sea snail, 10-20 parts of Physalis alkekengi, 10-20 parts of Pseudostellaria heterophylla, 8-16 parts of Dendrobium nobile, 8-16 parts of Paeonia lactiflora, 4-9 parts of Solanum nigrum, 5-15 parts of Cornus officinalis, 4-13 parts of Prunus mume, and 4-9 parts of Glycyrrhiza uralensis.

[0011] Preferably, the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 18 parts of Prunella vulgaris, 22 parts of Hedyotis diffusa, 22 parts of Fritillaria thunbergii, 20 parts of Polygonum cuspidatum, 18 parts of Polygonum hydropiper, 18 parts of Sea snail, 15 parts of Physalis alkekengi, 15 parts of Pseudostellaria heterophylla, 12 parts of Dendrobium nobile, 12 parts of Paeonia lactiflora, 6 parts of Solanum nigrum, 10 parts of Cornus officinalis, 8 parts of Prunus mume, and 6 parts of Glycyrrhiza uralensis.

[0012] Secondly, the present invention provides a method for preparing the traditional Chinese medicine preparation for postoperative recovery of thyroid cancer. The traditional Chinese medicine preparation is prepared into an oral dosage form by conventional pharmaceutical methods, with the addition of excipients, including decoction, granules, pills, powders, tablets, and capsules.

[0013] Preferably, the preparation steps of the decoction of the traditional Chinese medicine preparation include: weighing each raw material according to the above-mentioned weight proportions, washing the raw materials and soaking them for 30 minutes, adding water and heating to a boil over high heat, then simmering over low heat for 30 minutes, filtering out 200 mL of the decoction for later use; adding an equal amount of purified water to the dregs again, simmering over low heat for 20 minutes, filtering out 200 mL of the decoction; combining the two decoctions, mixing thoroughly, letting stand and cool, and then filtering to remove the dregs and precipitate to obtain the final product.

[0014] The pharmacological effects of each Chinese herbal raw material in the Chinese herbal preparation of this invention are as follows:

[0015] Oldenlandia diffusa: The whole herb of *Scleromitrion diffusum* (Willd.) RJWang, a plant in the Rubiaceae family. It has a sweet and bland taste, and is cool in nature. It enters the stomach, large intestine, and small intestine meridians. It has the effects of clearing heat and detoxifying, promoting diuresis and reducing swelling, and promoting blood circulation and relieving pain. It is used for appendicitis, boils and carbuncles, damp-heat jaundice, and difficulty urinating; externally, it is used to treat boils, carbuncles, and snake bites.

[0016] Dendrobium: Fresh or dried stems of cultivated Dendrobium nobile Lindl., Dendrobium huoshanense CZ Tang et SJ Cheng, Dendrobium chrysotoxum Lindl., or Dendrobium fimbriatum Hook., and similar species of the same genus. It has a sweet taste and slightly cold nature. It enters the stomach and kidney meridians. It has the effects of nourishing the stomach and promoting the production of body fluids, nourishing yin and clearing heat. It is used for febrile diseases with depletion of body fluids, dry mouth and thirst, stomach yin deficiency, poor appetite and dry retching, persistent low-grade fever after illness, yin deficiency with exuberant fire, steaming bone fever, blurred vision, and weakness of muscles and bones.

[0017] Polygonum cuspidatum: The dried rhizome and root of Polygonum cuspidatum Sieb. et Zucc., a plant in the Polygonaceae family. It has a slightly bitter taste and is slightly cold in nature. It enters the liver, gallbladder, and lung meridians. It has the effects of promoting diuresis and relieving jaundice, clearing heat and detoxifying, dispersing blood stasis and relieving pain, and stopping cough and resolving phlegm. It is used for damp-heat jaundice, urinary tract infections, leukorrhea, rheumatic pain, carbuncles and boils, burns, amenorrhea, abdominal masses, traumatic injuries, and cough due to lung heat.

[0018] Black nightshade: The whole herb of *Solanum nigrum* L., a plant in the Solanaceae family. It has a bitter taste and is cold in nature. It possesses the effects of clearing heat and detoxifying, promoting diuresis and reducing swelling. It is used for colds and fever, toothache, chronic bronchitis, dysentery, urinary tract infections, mastitis, leukorrhea, and cancer; externally, it is used to treat boils, carbuncles, pemphigus, and snake bites.

[0019] Water Polygonum orientale L. (Polygonaceae family): The dried, mature fruit of Polygonum orientale L. It has a salty taste and slightly cold properties. It enters the liver and stomach meridians. It has the effects of dispersing blood stasis and eliminating masses, relieving pain, and promoting diuresis and reducing swelling. It is used for abdominal masses, goiter, indigestion, abdominal distension and pain, and edema with ascites.

[0020] White peony root: The dried root of Paeonia lactiflora Pall., a plant in the Ranunculaceae family. It tastes bitter and sour, and is slightly cold in nature. It enters the liver and spleen meridians. It has the effects of nourishing blood and regulating menstruation, astringing yin and stopping sweating, softening the liver and relieving pain, and calming liver yang. It is used for blood deficiency and chlorosis, irregular menstruation, spontaneous sweating, night sweats, hypochondriac pain, abdominal pain, limb spasms, headache, and dizziness.

[0021] Physalis alkekengi L. var. franchetii (Mast.) Makino, a plant in the Solanaceae family. It has a bitter taste and cold properties. It enters the Lung meridian. It has the effects of clearing heat and detoxifying, relieving sore throat and resolving phlegm, and promoting urination. It is used for sore throat and hoarseness, cough with phlegm and heat, difficulty urinating, and painful urination due to heat; externally, it is used to treat pemphigus and eczema.

[0022] Prince Ginseng: The dried tuberous root of *Pseudostellaria heterophylla* (Miq.) Pax ex Paxet Hoffm., a plant in the Caryophyllaceae family. It has a sweet and slightly bitter taste, and is neutral in nature. It enters the spleen and lung meridians. It has the effects of invigorating qi and strengthening the spleen, promoting body fluid production and moistening the lungs. It is used for spleen deficiency with fatigue, loss of appetite, weakness after illness, qi and yin deficiency, spontaneous sweating and thirst, and dry cough due to lung dryness.

[0023] Green Plum Blossom: The dried flower of *Prunus mume* Sieb. et Zucc. var. *viridicalyx* Makino, a plant in the Rosaceae family. It has a bitter and slightly sweet taste, and is neutral in nature. It enters the liver, stomach, and lung meridians. It has the effect of calming the liver and stomach. It is used for chest and rib pain, stomach pain, indigestion, and neurasthenia.

[0024] Prunella vulgaris L. (also known as self-healing herb): The dried fruit spikes of the plant Prunella vulgaris L. (Lamiaceae family). It has a pungent and bitter taste, and is cold in nature. It enters the liver and gallbladder meridians. It has the effects of clearing liver heat, improving eyesight, and dispersing nodules and reducing swelling. It is used for red and swollen eyes, night pain in the eyes, headache and dizziness, scrofula, goiter, mastitis, breast lumps, and breast distension and pain.

[0025] Fritillaria thunbergii Miq., a plant in the Liliaceae family, is a dried bulb. It has a bitter taste and is cold in nature. It enters the lung and heart meridians. It has the effects of clearing heat, resolving phlegm, relieving cough, detoxifying, dissipating nodules, and reducing swelling. It is used for wind-heat cough, phlegm-fire cough, lung abscess, mastitis, scrofula, and carbuncles.

[0026] Mountain Sea Snail: The dried root of *Codonopsis lanceolat* (Sieb. et Zucc.) Trautv., a plant in the Campanulaceae family. It has a sweet and pungent taste, and is neutral in nature. It enters the spleen and lung meridians. It has the effects of invigorating qi and nourishing yin, detoxifying and reducing swelling, draining pus, and promoting lactation. It is used for symptoms such as fatigue, dizziness, headache, lung abscess, mastitis, intestinal abscess, boils and carbuncles, and insufficient lactation after childbirth.

[0027] Cornus officinalis fruit pulp: The dried, ripe pulp of Cornus officinalis Sieb. et Zucc., a plant in the Cornaceae family. It has a sour and astringent taste, and is slightly warm in nature. It enters the liver and kidney meridians. It has the effects of tonifying the liver and kidneys, and astringing and consolidating the body. It is used for dizziness and tinnitus, lower back and knee pain, impotence and seminal emission, enuresis and frequent urination, metrorrhagia and leukorrhea, profuse sweating and collapse, and internal heat and thirst.

[0028] (III) Beneficial Effects

[0029] This invention provides a traditional Chinese medicine preparation for postoperative recovery in thyroid cancer patients and its preparation method. The preparation is composed of *Prunella vulgaris*, *Hedyotis diffusa*, *Fritillaria thunbergii*, *Polygonum cuspidatum*, *Polygonum hydropiper*, *Spatholobus suberectus*, *Phyllostachys nigra*, *Pseudostellaria heterophylla*, *Pseudostellaria heterophylla*, *Dendrobium nobile*, *Paeonia lactiflora*, *Solanum nigrum*, *Cornus officinalis*, *Prunus mume*, and *Glycyrrhiza uralensis*. The entire formula closely addresses the core pathogenesis of thyroid cancer postoperative recovery, integrating phlegm-resolving and nodule-dispersing, heat-clearing and detoxifying, blood-stasis-dispersing and mass-eliminating, qi-tonifying and yin-nourishing, liver-soothing and stomach-harmonizing effects, treating both the root cause and the symptoms, and combining tonification and purgation. *Prunella vulgaris*, *Hedyotis diffusa*, and *Fritillaria thunbergii* are the principal herbs: *Prunella vulgaris* specifically enters the liver and gallbladder meridians, excelling at clearing liver fire, dispersing nodules and eliminating goiter. Its light and dispersing nature allows it to directly reach the site of scrofula and phlegm nodules, dispersing residual lumps after surgery. *Hedyotis diffusa* is bitter and cold in nature, effectively clearing heat and detoxifying, eliminating carbuncles and nodules, clearing residual heat toxins after surgery, and guiding damp-heat downwards. Fritillaria thunbergii, bitter and cold in nature, excels at clearing heat, resolving phlegm, dispersing nodules, and eliminating carbuncles. It can alleviate scrofula and lumps caused by phlegm-heat accumulation after surgery. The three principal herbs work synergistically to resolve phlegm, disperse nodules, clear heat, and detoxify. Polygonum cuspidatum, Polygonum hydropiper, Conch shell, and Physalis alkekengi are used as assistant herbs: Polygonum cuspidatum excels at clearing heat, detoxifying, promoting diuresis, relieving jaundice, and promoting blood circulation. It can clear heat stagnation in the blood, resolve local stagnation, and guide damp-heat downwards, assisting the principal herbs in clearing residual toxins after surgery, while also promoting diuresis and dispersing stagnation, improving local blood circulation after surgery. Polygonum hydropiper is salty and can enter the blood to soften hard masses. For residual stagnation after surgery, neck swelling and pain, it can disperse stagnation, eliminate nodules, and enhance the dispersing and eliminating effects of the principal herbs. Sea snail (Shan Hai Luo) excels at invigorating qi and nourishing yin, detoxifying and dispersing nodules, reducing swelling and draining pus. It not only assists the principal herb in clearing residual toxins and dispersing phlegm nodules and swellings in the anterior neck, but also replenishes qi and yin, alleviating postoperative weakness and fatigue, and insufficient yin fluids. Physalis alkekengi (Jin Deng Long) excels at clearing heat and detoxifying, soothing the throat and resolving phlegm, especially effective in relieving postoperative neck traction pain, swelling, dryness, and a foreign body sensation in the throat. These four assistant herbs complement each other, enhancing the principal herb's ability to clear and disperse nodules, while also clearing the throat, dispersing blood stasis and reducing swelling, invigorating qi and nourishing yin, thus addressing the postoperative deficiency of both qi and yin. The adjuvant herbs are: Codonopsis pilosula, Dendrobium nobile, Paeonia lactiflora, Solanum nigrum, Cornus officinalis, and Prunus mume. Codonopsis pilosula invigorates qi and strengthens the spleen, generates fluids and moistens the lungs; Dendrobium nobile nourishes yin and generates fluids, benefits the stomach and clears the lungs. Together, they consolidate the foundation of postoperative qi and yin deficiency and replenish the acquired qi of the spleen and stomach. White peony nourishes blood and softens the liver, astringes yin and stops sweating, relieves spasms and pain, alleviates postoperative neck stiffness and discomfort, harmonizes the liver and spleen, and relieves emotional depression and hypochondriac pain. Black nightshade clears heat and detoxifies, promotes diuresis and reduces swelling; its penetrating nature allows it to eliminate residual toxins and stagnation in the meridians, assisting the principal herb in clearing postoperative lesions. Cornus officinalis tonifies the liver and kidneys, astringes and consolidates, preventing postoperative depletion of vital energy and retaining body fluids, avoiding postoperative symptoms such as excessive sweating and dry mouth due to qi and yin deficiency. Green plum blossoms soothe the liver and stomach, regulate qi and relieve depression, alleviating postoperative chest, hypochondriac, and stomach distension and emotional distress. These six auxiliary herbs work together to simultaneously eliminate pathogens and support the body's vital energy, regulating qi and enhancing the overall efficacy of the formula, fully embodying the principle of eliminating pathogens without harming the body's vital energy and supporting the body's vital energy without lingering on pathogens. Licorice is used as the guiding herb: Licorice invigorates qi and replenishes the middle jiao, relieves spasms and pain, and harmonizes the properties of other herbs. It can not only moderate the bitter and cold nature of other herbs and coordinate the cold, warm, attacking, and tonifying properties of the whole prescription, but also guide other herbs directly to the disease site, so as to achieve the effect of supporting the body's resistance and eliminating pathogens, and addressing both the root cause and the symptoms.

[0030] Compared with existing technologies, the traditional Chinese medicine composition of this invention has significant beneficial effects, specifically reflected in the following two aspects:

[0031] Animal experiments showed that rats undergoing total thyroidectomy exhibited significant hypothalamic-pituitary-thyroid axis disorder, low expression of the thyroid-specific functional protein Tg, immune organ damage, and systemic immunosuppression, accompanied by lethargy, growth retardation, and poor postoperative recovery. The herbal preparation of this invention can significantly improve the systemic weakness in these rat models, effectively regulate postoperative thyroid hormone imbalances, significantly increase Tg expression levels, repair immune organ damage, reverse postoperative immunosuppression, and improve the overall survival and local postoperative damage in the rat models.

[0032] Clinical studies have further confirmed that the traditional Chinese medicine preparation of this invention precisely addresses the core pathogenesis of thyroid cancer surgery, characterized by a complex interplay of deficiency and excess, including qi and blood deficiency, phlegm and blood stasis, and liver qi stagnation. Combined with conventional Western medicine TSH treatment, this preparation offers multi-target and multi-dimensional postoperative rehabilitation advantages, achieving comprehensive therapeutic effects such as reducing postoperative complications, promoting bodily function repair, improving physical weakness and blood stasis, alleviating negative emotions, and enhancing quality of life. Specifically, it effectively reduces the risk of postoperative complications such as hypocalcemic numbness, incision infection, subcutaneous hematoma, and damage to the recurrent laryngeal nerve and superior laryngeal nerve; significantly improves neck and shoulder mobility; alleviates TCM deficiency and stagnation symptoms; relieves postoperative depression and anxiety; and comprehensively improves postoperative recovery and quality of life after tumor surgery. In conclusion, the traditional Chinese medicine preparation of this invention is safe, reliable, and effective for the recovery period after thyroid cancer surgery, possessing excellent clinical application value and promising prospects for promotion. Attached Figure Description

[0033] Figure 1 The results show the serum IgA (a), IgG (b), and IgM (c) levels and the thymus (d) and spleen (e) indices of rats in each group after drug administration. Compared with the sham-operated group, * indicates P<0.05, ** indicates P<0.01; compared with the model control group, # indicates P<0.05, ## indicates P<0.01.

[0034] Figure 2 This study compared the CMS (a), QLQ-C30 (b), HAMD (c), and TCM syndrome scores (d) of the two groups of patients before and after drug intervention. For comparisons with before drug intervention, # indicates P < 0.05, and ## indicates P < 0.01; for comparisons with the control group after treatment, * indicates P < 0.05, and ** indicates P < 0.01. Detailed Implementation

[0035] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0036] Example 1

[0037] A traditional Chinese medicine preparation for postoperative recovery after thyroid cancer surgery, the preparation being made from the following raw materials in parts by weight: 18 parts of Prunella vulgaris, 22 parts of Hedyotis diffusa, 22 parts of Fritillaria thunbergii, 20 parts of Polygonum cuspidatum, 18 parts of Polygonum hydropiper, 18 parts of Concha thunbergii, 15 parts of Physalis alkekengi, 15 parts of Pseudostellaria heterophylla, 12 parts of Dendrobium nobile, 12 parts of Paeonia lactiflora, 6 parts of Solanum nigrum, 10 parts of Cornus officinalis, 8 parts of Prunus mume, and 6 parts of Glycyrrhiza uralensis.

[0038] Example 2

[0039] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 12 parts of Prunella vulgaris, 18 parts of Hedyotis diffusa, 18 parts of Fritillaria thunbergii, 15 parts of Polygonum cuspidatum, 12 parts of Polygonum hydropiper, 12 parts of Sea snail, 10 parts of Physalis alkekengi, 10 parts of Pseudostellaria heterophylla, 8 parts of Dendrobium nobile, 8 parts of Paeonia lactiflora, 4 parts of Solanum nigrum, 5 parts of Cornus officinalis, 4 parts of Prunus mume, and 4 parts of Glycyrrhiza uralensis.

[0040] Example 3

[0041] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 24 parts of Prunella vulgaris, 28 parts of Hedyotis diffusa, 28 parts of Fritillaria thunbergii, 25 parts of Polygonum cuspidatum, 24 parts of Polygonum hydropiper, 24 parts of Sea snail, 20 parts of Physalis alkekengi, 20 parts of Pseudostellaria heterophylla, 16 parts of Dendrobium nobile, 16 parts of Paeonia lactiflora, 9 parts of Solanum nigrum, 15 parts of Cornus officinalis, 13 parts of Prunus mume, and 9 parts of Glycyrrhiza uralensis.

[0042] Example 4

[0043] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 8 parts of Prunella vulgaris, 12 parts of Hedyotis diffusa, 12 parts of Fritillaria thunbergii, 10 parts of Polygonum cuspidatum, 8 parts of Polygonum hydropiper, 8 parts of Sea snail, 5 parts of Physalis alkekengi, 5 parts of Pseudostellaria heterophylla, 4 parts of Dendrobium nobile, 4 parts of Paeonia lactiflora, 3 parts of Solanum nigrum, 3 parts of Cornus officinalis, 3 parts of Prunus mume, and 3 parts of Glycyrrhiza uralensis.

[0044] Example 5

[0045] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 30 parts of Prunella vulgaris, 32 parts of Hedyotis diffusa, 32 parts of Fritillaria thunbergii, 30 parts of Polygonum cuspidatum, 30 parts of Polygonum hydropiper, 30 parts of Sea snail, 25 parts of Physalis alkekengi, 25 parts of Pseudostellaria heterophylla, 20 parts of Dendrobium nobile, 20 parts of Paeonia lactiflora, 12 parts of Solanum nigrum, 20 parts of Cornus officinalis, 18 parts of Prunus mume, and 12 parts of Glycyrrhiza uralensis.

[0046] Example 6

[0047] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 10 parts of Prunella vulgaris, 16 parts of Hedyotis diffusa, 16 parts of Fritillaria thunbergii, 12 parts of Polygonum cuspidatum, 10 parts of Polygonum hydropiper, 10 parts of Sea snail, 8 parts of Physalis alkekengi, 7 parts of Pseudostellaria heterophylla, 5 parts of Dendrobium nobile, 6 parts of Paeonia lactiflora, 3 parts of Solanum nigrum, 4 parts of Cornus officinalis, 3 parts of Prunus mume, and 3 parts of Glycyrrhiza uralensis.

[0048] Example 7

[0049] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 28 parts of Prunella vulgaris, 30 parts of Hedyotis diffusa, 30 parts of Fritillaria thunbergii, 28 parts of Polygonum cuspidatum, 26 parts of Polygonum hydropiper, 26 parts of Sea snail, 22 parts of Physalis alkekengi, 22 parts of Pseudostellaria heterophylla, 17 parts of Dendrobium nobile, 18 parts of Paeonia lactiflora, 10 parts of Solanum nigrum, 18 parts of Cornus officinalis, 15 parts of Prunus mume, and 10 parts of Glycyrrhiza uralensis.

[0050] Example 8

[0051] The difference between this embodiment and Embodiment 1 is that the traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 16 parts of Prunella vulgaris, 20 parts of Hedyotis diffusa, 20 parts of Fritillaria thunbergii, 18 parts of Polygonum cuspidatum, 16 parts of Polygonum hydropiper, 16 parts of Sea snail, 12 parts of Physalis alkekengi, 13 parts of Pseudostellaria heterophylla, 10 parts of Dendrobium nobile, 10 parts of Paeonia lactiflora, 5 parts of Solanum nigrum, 8 parts of Cornus officinalis, 5 parts of Prunus mume, and 5 parts of Glycyrrhiza uralensis.

[0052] Experimental Example 1

[0053] 1. Experimental Materials

[0054] 1.1 Laboratory Animals

[0055] Sixty SPF-grade male SD rats, aged 6-8 weeks and weighing 200±20g, were purchased from Henan Skbes Biotechnology Co., Ltd.

[0056] 1.2 Experimental Drugs

[0057] This invention relates to a traditional Chinese medicine preparation: Composition: 18g of Prunella vulgaris, 22g of Hedyotis diffusa, 22g of Fritillaria thunbergii, 20g of Polygonum cuspidatum, 18g of Polygonum hydropiper, 18g of Sea snail, 15g of Physalis alkekengi, 15g of Pseudostellaria heterophylla, 12g of Dendrobium nobile, 12g of Paeonia lactiflora, 6g of Solanum nigrum, 10g of Cornus officinalis, 8g of Prunus mume, and 6g of Glycyrrhiza uralensis. The above ingredients are decocted with water, concentrated to obtain an extract, and dried to obtain a dry extract powder. Before use, a suspension of the appropriate concentration is prepared with physiological saline.

[0058] Levothyroxine sodium tablets: Trade name: Euthyrox, Manufacturer: Merck AG, Germany, Specification: 50 μg (calculated as levothyroxine sodium), National Drug Approval Number: H20140052. Before use, grind with physiological saline to prepare a suspension of the required concentration.

[0059] 2 Experimental Methods

[0060] 2.1 Modeling Method

[0061] A rat model was established using total thyroidectomy. The specific method was as follows: Rats were anesthetized with sodium pentobarbital (40 mg / kg). The neck skin was routinely disinfected, and a midline incision was made in the anterior neck. The subcutaneous tissue and anterior neck muscles were dissected layer by layer to expose the bilateral thyroid glands. After complete removal of both thyroid tissues, the incision was sutured layer by layer. Postoperatively, penicillin was administered intraperitoneally for three consecutive days to prevent infection. Serum TSH and T4 levels were measured two weeks postoperatively to confirm successful model establishment. A sham-operated group was established using the same method, in which only the neck skin was incised to expose the thyroid gland, and the incision was immediately sutured layer by layer without removing the thyroid tissue. This group served as a baseline control for normal physiological function.

[0062] 2.2 Grouping and Dosing

[0063] The experiment included a sham surgery group, a model control group, a low-dose traditional Chinese medicine (TCM) preparation group, a medium-dose TCM preparation group, a high-dose TCM preparation group, and a positive control group, with 10 animals in each group. All groups received the same intervention method: gavage administration at a dose of 10 mL / kg for 4 weeks, as follows:

[0064] The sham surgery group was given an equal volume of normal saline by gavage;

[0065] The model control group was given an equal volume of physiological saline by gavage;

[0066] The low-dose group of the traditional Chinese medicine preparation was administered 9g of raw herb / kg of the traditional Chinese medicine preparation of this invention via gavage;

[0067] The medium-dose group of the traditional Chinese medicine preparation was administered 18g of raw herb / kg of the traditional Chinese medicine preparation of this invention by gavage;

[0068] The high-dose group of the traditional Chinese medicine preparation was administered 36g of raw herb / kg of the traditional Chinese medicine preparation of this invention via gavage;

[0069] The positive control group was given 18 μg / kg levothyroxine sodium tablets by gavage.

[0070] 2.3 Sample Collection

[0071] After the last administration, rats in each group were fasted for 12 hours. After anesthesia with intraperitoneal injection of sodium pentobarbital (50 mg / kg), blood was collected via the abdominal aorta. After standing at room temperature for 30 minutes, the blood was centrifuged at 3000 rpm for 15 minutes at 4°C to separate the serum, which was then aliquoted and stored at -80°C for later use. Rats were euthanized after blood collection, and thymus and spleen tissues were dissected, rinsed with physiological saline, blotted dry with filter paper, weighed, and organ indices calculated.

[0072] 3. Detection Indicators and Methods

[0073] 3.1 General Condition Observation

[0074] During the experiment, the rats' mental state, food and water intake, activity level, and fur color were observed daily; their weight was recorded weekly, and the healing of surgical incisions and the presence of abnormal swelling or nodule formation in the neck were observed.

[0075] 3.2 Thyroid function indicators

[0076] Serum samples were collected, thawed at room temperature, and serum TSH, FT3, FT4, and Tg levels were measured to assess the postoperative recovery of thyroid axis function in each group of rats.

[0077] 3.3 Immune function indicators

[0078] Serum samples were collected, thawed at room temperature, and serum IgA, IgG, and IgM levels were measured. Thymus and spleen tissues were harvested, organ indices were calculated, and postoperative immune status and the body's defense capabilities were assessed.

[0079] 3.4 Statistical Methods

[0080] Data analysis was performed using GraphPad Prism 8.0 statistical software. Quantitative data are expressed as mean ± standard deviation. One-way ANOVA was used for comparisons among multiple groups, and LSD-t test (for homogeneous variances) or Tamhane's T2 test (for unequal variances) was used for pairwise comparisons between groups. A p-value < 0.05 was considered statistically significant, and a p-value < 0.01 was considered extremely significant.

[0081] 4 Results

[0082] 4.1 Comparison of general condition of rats in each group

[0083] During the experiment, the rats in the sham-operated group were in good mental condition, responsive, with glossy and smooth fur, normal food and water intake, physiological weight gain, good wound healing, and no abnormal swelling in the neck.

[0084] In the model control group, rats exhibited lethargy, reduced spontaneous activity, a tendency to curl up and lie down, rough and dull fur, decreased food and water intake, and slow weight gain after surgery. Some rats also showed mild swelling in their necks.

[0085] The general condition of rats in all dosage groups of the traditional Chinese medicine preparation of this invention and the positive control group was significantly improved compared with that of the model control group. Among them, the rats in the positive control group recovered well in terms of diet, mental state and weight, but the effect on improving local swelling and tissue adhesion in the neck was limited. The low, medium and high dose groups of the traditional Chinese medicine preparation of this invention showed significant dose-dependent improvement characteristics. As the dosage increased, the rats' mental state, activity ability, diet and water intake and hair growth gradually recovered, the neck incision healed well, and the symptoms of local swelling and tissue adhesion were significantly relieved. The overall condition of rats in the high dose group was close to that of the sham surgery group.

[0086] 4.2 Comparison of thyroid function indicators among different groups of rats

[0087] After the drug intervention, the serum thyroid function indicators of rats in each group were measured as shown in Table 1. Compared with the sham-operated group, the serum TSH level of rats in the model control group was significantly increased, while the levels of FT3, FT4, and Tg were significantly decreased, and the differences were statistically significant (P<0.01), confirming that thyroid hormone secretion disorder existed in rats after total thyroidectomy, and the model was successfully established.

[0088] Compared with the model control group, in the positive control group rats, after intervention with levothyroxine sodium, FT3 and FT4 levels significantly increased, and TSH was suppressed to near normal levels (P<0.01). Basic metabolic indicators of thyroid function were significantly improved, but Tg levels showed no significant change (P>0.05). The low, medium, and high dose groups of the traditional Chinese medicine preparation of this invention all downregulated serum TSH levels and upregulated FT3, FT4, and Tg levels to varying degrees, showing a clear dose-dependent effect (P<0.05 or P<0.01). Among them, the high-dose group showed the most significant improvement in all thyroid function indicators. These results indicate that the traditional Chinese medicine preparation of this invention can significantly improve thyroid dysfunction after thyroid cancer surgery.

[0089] Table 1. Results of serum thyroid function indicators in rats of each group

[0090]

[0091] Note: Compared with the sham surgery group, ** indicates P<0.01; compared with the model control group, # indicates P<0.05, and ## indicates P<0.01.

[0092] 4.3 Comparison of humoral immune indicators and immune organ indices among rat groups

[0093] After the drug intervention, the results of humoral immune indicators and immune organ indices of rats in each group are as follows: Figure 1As shown in the figure. Compared with the sham-operated group, the serum levels of IgA, IgG, and IgM in the model control group rats were significantly reduced (P<0.01), and the thymus index and spleen index were significantly decreased (P<0.01), indicating that the body's immune defense function was impaired after surgery.

[0094] Compared with the model control group, the serum IgA, IgG, IgM, and organ indices of rats in the positive control group showed a slight increase, but the improvement was limited, indicating that hormone therapy alone could not repair postoperative immune function damage. In the traditional Chinese medicine preparation of this invention, the serum IgA, IgG, and IgM levels, as well as the thymus and spleen indices, of rats in all dosage groups showed a significant increase in a dose-dependent manner, with the high-dose group showing the most significant improvement in immune indicators. These results indicate that the traditional Chinese medicine preparation of this invention can effectively reverse the postoperative immunosuppression state after thyroid cancer surgery, enhance humoral immunity, improve the function of immune organs, and improve the postoperative immunodeficiency state.

[0095] 5. Conclusion

[0096] In summary, rats undergoing total thyroidectomy exhibited significant pathological changes, including hormonal metabolic disorders, loss of thyroid-specific functional proteins, immunosuppression, and overall deterioration. Traditional Chinese medicine hormone replacement therapy alone can only correct peripheral thyroid hormone levels and cannot effectively improve the low Tg expression associated with postoperative thyroid tissue damage, immune impairment, and systemic deterioration. The herbal preparation of this invention can effectively regulate postoperative thyroid axis function, increase Tg expression levels, repair immune organ damage, and reverse postoperative immunosuppression in a dose-dependent manner, while simultaneously improving the overall survival and local postoperative damage in rats.

[0097] Experimental Example 2

[0098] 1. Materials and Methods

[0099] 1.1 General Information

[0100] One hundred and fourteen patients with thyroid cancer admitted between January 2025 and March 2026 were selected and randomly divided into a control group and an observation group, with 57 patients in each group. In the control group, there were 24 males and 33 females, aged 19-69 years, with a mean age of (46.68±13.33) years. There were 48 cases of papillary carcinoma and 9 cases of follicular carcinoma. TNM staging was as follows: stage I (31 cases), stage II (18 cases), and stage III (8 cases). In the observation group, there were 20 males and 37 females, aged 20-68 years, with a mean age of (48.26±12.40) years. There were 46 cases of papillary carcinoma and 11 cases of follicular carcinoma. TNM staging was as follows: stage I (28 cases), stage II (22 cases), and stage III (7 cases). There were no statistically significant differences in gender, age, or other general characteristics between the two groups (P>0.05), indicating comparability between the groups.

[0101] 1.2 Diagnostic Criteria

[0102] 1.2.1 Western Medicine Diagnostic Criteria

[0103] All patients met the diagnostic criteria for differentiated thyroid cancer in the "Guidelines for the Diagnosis and Treatment of Thyroid Cancer (2022 Edition)," were diagnosed by pathological examination, and underwent radical thyroidectomy.

[0104] 1.2.2 Traditional Chinese Medicine Diagnostic Criteria

[0105] Referring to the diagnostic criteria for Qi and Yin deficiency and phlegm-toxin stagnation syndrome after thyroid cancer surgery in "Integrated Traditional Chinese and Western Medicine Oncology", the main symptoms are fatigue, shortness of breath, and reluctance to speak. The secondary symptoms are dry throat and mouth, palpitations, insomnia, spontaneous sweating and night sweats, soreness and weakness of the lower back and knees, dizziness, red tongue with little coating, and thready and rapid pulse.

[0106] 1.3 Inclusion Criteria

[0107] Age 18-70 years; meeting the above-mentioned diagnostic criteria in both traditional Chinese and Western medicine; all undergoing radical thyroidectomy for thyroid cancer and entering the recovery period within 1 week post-surgery; signing informed consent forms; and not participating in other clinical trials within the past 3 months.

[0108] 1.4 Exclusion Criteria

[0109] Individuals who are allergic to or have an allergic constitution to the drugs or components used in this trial; pregnant or lactating women; those with other malignant tumors, severe heart, liver or kidney dysfunction; those with severe mental illness or cognitive impairment that prevents them from cooperating; or those with autoimmune diseases or coagulation disorders.

[0110] 1.5 Treatment Methods

[0111] Control group: Patients received routine treatment with levothyroxine sodium tablets [trade name: Euthyrox, manufacturer: Merck AG, Germany, specification: 50 μg (calculated as levothyroxine sodium), national drug approval number H20140052]. Initial dosage was determined based on patient weight and thyroid function levels. Individualized dosage adjustments were made according to postoperative TSH suppression therapy targets (maintaining TSH at 0.1-0.5 mIU / L for high-risk patients and 0.5-2.0 mIU / L for low-risk patients), with continuous treatment for 4 weeks.

[0112] Observation group: In addition to the treatment given to the control group, the traditional Chinese medicine preparation of this invention was used. The formula consists of: Prunella vulgaris 18g, Hedyotis diffusa 22g, Fritillaria thunbergii 22g, Polygonum cuspidatum 20g, Polygonum hydropiper 18g, Sea snail 18g, Physalis alkekengi 15g, Pseudostellaria heterophylla 15g, Dendrobium nobile 12g, Paeonia lactiflora 12g, Solanum nigrum 6g, Cornus officinalis 10g, Prunus mume 8g, and Glycyrrhiza uralensis 6g. One dose is taken daily, decocted in water to obtain 400mL of liquid, and taken warm twice daily (morning and evening) for four consecutive weeks.

[0113] 1.6 Observation Indicators

[0114] 1.6.1 Complications

[0115] The incidence of various complications in the two groups of patients from surgery to 3 months after the end of drug intervention was statistically analyzed. The main complications included: hypocalcemia, manifested as numbness in the hands, feet or lips, positive Chvostek's sign or Trousseau's sign, and mild muscle twitching; bleeding or hematoma; incision infection; recurrent laryngeal nerve injury, manifested as hoarseness and vocal fatigue; and superior laryngeal nerve injury, manifested as choking when drinking and decreased pitch.

[0116] 1.6.2 Recovery status of shoulder and neck function

[0117] The Constant-Murley Score (CMS) was used to assess the recovery of neck and shoulder function in both groups of patients before and after drug intervention. The scale includes four dimensions: pain (15 points), activities of daily living (20 points), range of motion (40 points), and muscle strength (25 points), with a total score of 100 points. The higher the score, the better the recovery of neck and shoulder function.

[0118] 1.6.3 Quality of Life Score

[0119] The quality of life of patients was assessed using the Cancer Patient Quality of Life Assessment Scale (EORTC QLQ-C30, Chinese version) before and after drug intervention. This functional scale includes five dimensions: social functioning, role functioning, physical functioning, cognitive functioning, and emotional functioning. The scores of each dimension were linearly converted to 0-100 points, with higher scores indicating better quality of life.

[0120] 1.6.4 Psychological state score

[0121] The Hamilton Depression Scale (HAMD) was used to assess the patients' psychological state before and after the drug intervention. The scale includes five dimensions: depressive mood, obsessive-compulsive symptoms, sleep disorders, feelings of inferiority, and paranoid symptoms. Each dimension has a maximum score of 4 points, and the lower the score, the better the patient's psychological state.

[0122] 1.6.5 Traditional Chinese Medicine Syndrome Scoring

[0123] Before and after drug intervention, the primary symptoms (fatigue, shortness of breath, and reluctance to speak) and secondary symptoms (dry throat and mouth, palpitations, insomnia, spontaneous sweating, night sweats, and soreness and weakness of the lower back and knees) were graded and quantitatively scored according to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines". The primary symptoms were scored as follows: none (0 points), mild (2 points), moderate (4 points), and severe (6 points); the secondary symptoms were scored as follows: none (0 points), mild (1 point), moderate (2 points), and severe (3 points). The improvement of TCM syndromes in the two groups was evaluated.

[0124] 1.7 Statistical Methods

[0125] Data analysis was performed using GraphPad Prism 8.0 statistical software. Quantitative data were expressed as mean ± standard deviation. Paired-samples t-tests were used for comparisons within groups before and after treatment; independent-samples t-tests were used for comparisons between groups. Categorical data were expressed as number of cases (percentage) [n (%)], and chi-square tests were used for comparisons between groups. 2 Test. A p-value < 0.05 is considered statistically significant.

[0126] 2 Results

[0127] 2.1 Comparison of postoperative complication rates between the two groups of patients

[0128] The incidence of postoperative complications in the two groups during the intervention period is shown in Table 2. The total incidence of postoperative complications in the control group was 15.79%, while that in the observation group was 3.51%, which was significantly lower than that in the control group (P<0.05).

[0129] Table 2 Comparison of complication rates between the two groups [n(%)]

[0130]

[0131] 2.2 Comparison of shoulder and neck function scores between the two groups of patients

[0132] Depend on Figure 2 As shown in Figure a, before the drug intervention, there was no statistically significant difference in CMS scores between the two groups (P>0.05). After the drug intervention, the CMS scores of both groups increased significantly compared with those before the intervention (P<0.05), and the CMS scores of the observation group were significantly higher than those of the control group (P<0.05).

[0133] 2.3 Comparison of quality of life scores between the two groups of patients

[0134] Depend on Figure 2 As shown in b, before the drug intervention, there was no statistically significant difference in QLQ-C30 scores between the two groups (P>0.05). After the drug intervention, the QLQ-C30 scores of both groups were significantly higher than before the intervention (P<0.05), and the QLQ-C30 scores of the observation group were significantly higher than those of the control group at the same time point (P<0.05).

[0135] 2.4 Comparison of psychological status scores between the two groups of patients

[0136] Depend on Figure 2 As shown in c, before the drug intervention, there was no statistically significant difference in HAMD scores between the two groups (P>0.05). After the drug intervention, HAMD scores in both groups decreased significantly (P<0.05), and the decrease in the observation group was significantly greater than that in the control group (P<0.05).

[0137] 2.5 Comparison of TCM syndrome scores between the two groups of patients

[0138] Depend on Figure 2 As shown in d, before the drug intervention, there were no significant differences in the main symptoms, secondary symptoms, and total syndrome scores between the two groups (P>0.05). After the drug intervention, the TCM syndrome scores of both groups decreased significantly compared with before treatment (P<0.05), and the syndrome score of the observation group was significantly lower than that of the control group (P<0.05).

[0139] 3. Conclusion

[0140] The herbal preparation of this invention has a rigorous formulation with a clear hierarchy of principal, assistant, adjuvant, and guide herbs, precisely targeting the complex pathological characteristics of thyroid cancer surgery involving both deficiency and excess. Clinical studies have confirmed that combining this herbal preparation with conventional Western TSH suppression therapy can leverage the multi-target and multi-dimensional advantages of postoperative rehabilitation, achieving comprehensive therapeutic effects such as reducing postoperative complications, promoting physical function repair, improving physical weakness and blood stasis, alleviating negative emotions, and enhancing quality of life. Specifically, it effectively reduces the risk of postoperative complications such as hypocalcemic numbness, incision infection, subcutaneous hematoma, and damage to the recurrent laryngeal nerve and superior laryngeal nerve; significantly improves neck and shoulder mobility; alleviates TCM deficiency and stagnation syndromes; relieves postoperative depression and anxiety; and comprehensively improves the level of postoperative recovery and quality of life after tumor surgery. In conclusion, the herbal preparation of this invention is safe, reliable, and effective for the recovery period after thyroid cancer surgery, possessing good clinical application value and promising prospects for promotion.

[0141] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A traditional Chinese medicine preparation for postoperative recovery after thyroid cancer surgery, characterized in that, The traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 8-30 parts of Prunella vulgaris, 12-32 parts of Hedyotis diffusa, 12-32 parts of Fritillaria thunbergii, 10-30 parts of Polygonum cuspidatum, 8-30 parts of Polygonum hydropiper, 8-30 parts of Spatholobus suberectus, 5-25 parts of Physalis alkekengi, 5-25 parts of Pseudostellaria heterophylla, 4-20 parts of Dendrobium nobile, 4-20 parts of Paeonia lactiflora, 3-12 parts of Solanum nigrum, 3-20 parts of Cornus officinalis, 3-18 parts of Prunus mume, and 3-12 parts of Glycyrrhiza uralensis.

2. The traditional Chinese medicine preparation for postoperative recovery of thyroid cancer according to claim 1, characterized in that, The traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 12-24 parts of Prunella vulgaris, 18-28 parts of Hedyotis diffusa, 18-28 parts of Fritillaria thunbergii, 15-25 parts of Polygonum cuspidatum, 12-24 parts of Polygonum hydropiper, 12-24 parts of Sea snail, 10-20 parts of Physalis alkekengi, 10-20 parts of Pseudostellaria heterophylla, 8-16 parts of Dendrobium nobile, 8-16 parts of Paeonia lactiflora, 4-9 parts of Solanum nigrum, 5-15 parts of Cornus officinalis, 4-13 parts of Prunus mume, and 4-9 parts of Glycyrrhiza uralensis.

3. The traditional Chinese medicine preparation for postoperative recovery of thyroid cancer according to claim 1, characterized in that, The traditional Chinese medicine preparation is made from the following raw materials in parts by weight: 18 parts of Prunella vulgaris, 22 parts of Hedyotis diffusa, 22 parts of Fritillaria thunbergii, 20 parts of Polygonum cuspidatum, 18 parts of Polygonum hydropiper, 18 parts of Sea snail, 15 parts of Physalis alkekengi, 15 parts of Pseudostellaria heterophylla, 12 parts of Dendrobium nobile, 12 parts of Paeonia lactiflora, 6 parts of Solanum nigrum, 10 parts of Cornus officinalis, 8 parts of Prunus mume, and 6 parts of Glycyrrhiza uralensis.

4. A method for preparing a traditional Chinese medicine preparation for postoperative recovery of thyroid cancer as described in any one of claims 1-3, characterized in that, The traditional Chinese medicine preparations are prepared into oral dosage forms, including decoctions, granules, pills, powders, tablets, and capsules, using conventional pharmaceutical methods and excipients.

5. The preparation method according to claim 4, characterized in that, The preparation steps of the decoction of the traditional Chinese medicine preparation include: weighing each raw material according to the above weight proportions, washing the raw materials and soaking them for 30 minutes, adding water and heating to a boil over high heat, then simmering over low heat for 30 minutes, filtering out 200 mL of the decoction for later use; adding an equal amount of purified water to the dregs again, simmering over low heat for 20 minutes, filtering out 200 mL of the decoction; combining the two decoctions, mixing thoroughly, letting stand and cool, and then filtering to remove the dregs and precipitate to obtain the final product.

Images