A traditional Chinese medicine composition for removing metabolic body odor and an umbilical patch preparation thereof

Abstract

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for removing metabolic body odor and an umbilical patch preparation thereof, which is prepared from the following raw medicinal materials by weight: 10-20 parts of pachouli, 18-32 parts of pellitory, 10-20 parts of Chinese atractylodes rhizome, 5-15 parts of magnolia officinalis, 0.5-3 parts of amomum villosum, 5-15 parts of amomum kravanh, 3-10 parts of perilla leaf, 3-10 parts of pericarpium ziziphi, 10-20 parts of bupleurum, 10-20 parts of mugwort leaf, and 5-15 parts of semen cassiae. The composition is aimed at three pathogenesis of weak spleen and stomach, kidney essence deficiency, and blood stasis due to qi stagnation, and is used for removing dampness, regulating qi, promoting blood circulation, and tonifying kidney, so as to block the generation of abnormal body odor from the source. The traditional Chinese medicine composition can be prepared into an umbilical patch preparation or an oral decoction. The umbilical patch preparation utilizes the physiological characteristics that the navel is directly connected with viscera and meridians, so that the medicine is absorbed into the systemic circulation through the skin, effectively avoiding the first-pass metabolism and gastrointestinal burden of oral administration, and being safe and free of side effects. The present application is simple to prepare, flexible in administration, and has a good clinical application prospect.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine composition for removing metabolic body odor and its umbilical patch preparation. Background Technology

[0002] Metabolic body odor refers to an abnormal body odor caused by dysfunction of internal organs and abnormal metabolism of qi, blood, and body fluids. It is commonly seen in middle-aged and elderly people, obese individuals, and patients with metabolic syndrome. The difference between metabolic body odor and ordinary body odor is that this odor does not originate from the decomposition of sweat or dirt on the skin surface by microorganisms. Instead, it is caused by endogenous metabolic products produced by digestion, water metabolism, and blood circulation disorders, which are released through skin pores or respiration. Specifically, dysfunction of the spleen and stomach leads to undigested food and water, resulting in dampness and turbidity. This dampness rises to the mouth as halitosis and seeps to the skin surface as body odor. Kidney essence deficiency leads to impaired qi transformation, causing internal retention of dampness and turbidity, which rises to the skin. Qi stagnation and blood stasis hinder blood circulation, and the combination of blood stasis and dampness results in a putrid odor that may manifest as a rusty or fishy smell. These three pathogenesis mechanisms are often intertwined and mutually causal, jointly constituting the fundamental cause of metabolic body odor.

[0003] Currently, known technologies for improving or eliminating body odor are mainly divided into two categories: external masking products and oral conditioning products. External masking products typically use fragrances, aromatics, or antibacterial ingredients as their main raw materials. They are applied to the skin through spraying, smearing, or patching, using fragrance to mask the original odor or inhibit bacteria on the skin from breaking down sweat, thereby reducing odor production. These products are mostly in the form of sprays, roll-ons, deodorant creams, or aromatic patches. Oral conditioning products mainly consist of traditional Chinese medicine decoctions, pills, or granules. After being taken orally, they are absorbed through the gastrointestinal tract and enter the bloodstream, acting on the internal organs to improve metabolic function from within. In addition, there are also auxiliary methods that use physical means such as moxibustion and fumigation to stimulate acupoints on the skin surface to regulate organ function.

[0004] However, the aforementioned existing technologies all have their limitations in practical applications. External covering products, due to their mechanism of action, can only temporarily mask or inhibit bacteria on the skin surface, failing to intervene in the generation and elimination of metabolic products such as dampness, turbidity, and blood stasis within the body. Once the product expires or is discontinued, the body odor returns to its original state, representing a typical case of treating the symptoms but not the root cause. Oral conditioning products, while able to regulate organ function internally, require digestion and absorption by the digestive system and first-pass metabolism by the liver. A significant proportion of the active ingredients are lost before reaching the target tissue. Furthermore, long-term oral administration may increase the digestive burden on individuals with already weak spleen and stomach function, affecting the stable efficacy of the medication. Physical stimulation methods, due to their complexity, need for professional guidance, and short duration of action, are difficult to use as a daily, continuous conditioning method. Therefore, how to achieve continuous and effective conditioning of visceral metabolic function without increasing the burden on the digestive system, thereby eliminating metabolic body odor from its root, has become a pressing technical problem in this field. To this end, a traditional Chinese medicine composition for eliminating metabolic body odor and its umbilical patch preparation are proposed. Summary of the Invention

[0005] In view of this, the present invention provides a traditional Chinese medicine composition for removing metabolic body odor and its umbilical patch preparation, so as to solve or alleviate the technical problems existing in the prior art, and at least provide a beneficial option.

[0006] The technical solution of this invention is achieved as follows: a traditional Chinese medicine composition for removing metabolic body odor, made from the following raw materials in parts by weight:

[0007] Patchouli 10-20 parts, Eupatorium fortunei 18-32 parts, Atractylodes lancea 10-20 parts, Magnolia officinalis 5-15 parts, Amomum villosum 0.5-3 parts, Amomum cardamomum 5-15 parts, Perilla frutescens 3-10 parts, Areca catechu 3-10 parts, Bupleurum chinense 10-20 parts, Artemisia argyi 10-20 parts, Cuscuta chinensis 5-15 parts.

[0008] A further preferred embodiment is made from the following parts by weight of active pharmaceutical ingredient:

[0009] Patchouli 15 parts, Eupatorium fortunei 25 parts, Atractylodes lancea 15 parts, Magnolia officinalis 10 parts, Amomum villosum 1 part, Amomum cardamomum 10 parts, Perilla frutescens 6 parts, Areca catechu 6 parts, Bupleurum chinense 15 parts, Artemisia argyi 15 parts, Cuscuta chinensis 10 parts.

[0010] More preferably, the metabolic body odor includes one or more of the following: halitosis and body odor caused by spleen and stomach weakness, body odor caused by kidney essence deficiency, and body odor with a rusty or fishy smell caused by qi stagnation and blood stasis.

[0011] More preferably, it includes a core layer and a backing layer, wherein the core layer comprises the traditional Chinese medicine composition according to claim 1 or 2.

[0012] More preferably, the core layer is made of the powder of the traditional Chinese medicine composition and pharmaceutically acceptable excipients; the pharmaceutically acceptable excipients include one or more of petrolatum, honey, glycerin, and vinegar.

[0013] More preferably, the core layer is circular or square in shape, 0.2-1.0 cm thick, and weighs 1-5 grams; the backing layer is medical non-woven fabric or medical breathable tape.

[0014] The application of the traditional Chinese medicine composition of the present invention in the preparation of a medicine for removing metabolic body odor.

[0015] More preferably, the dosage form of the drug is an umbilical patch or an oral decoction.

[0016] This invention provides a method for preparing an umbilical patch for removing metabolic body odor, comprising the following steps:

[0017] S1 Weigh each raw material according to the weight parts described in claim 1 or 2, dry them, mix them evenly, pulverize them into fine powder, and sieve them.

[0018] S2 Add pharmaceutically acceptable excipients to the fine powder obtained in step S1, mix evenly, and make a soft material or paste.

[0019] S3. The soft material or paste obtained in step S2 is shaped into a core layer and placed on the backing layer to obtain the final product.

[0020] More preferably, in step S1, the sieve mesh size is 80-200 mesh; in step S2, the pharmaceutically acceptable excipient is petrolatum, and the weight ratio of the fine powder to petrolatum is 1:0.5-1:2.

[0021] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions:

[0022] I. The provided traditional Chinese medicine composition and its umbilical patch preparation target the three major pathogenesis of metabolic body odor: spleen and stomach weakness, kidney essence deficiency, and qi stagnation and blood stasis. It employs multiple methods including dampness-resolving, qi-regulating, blood-activating, and kidney-tonifying. The formula contains: Patchouli and Eupatorium fortunei aromatically resolve dampness; Atractylodes lancea and Magnolia officinalis dry dampness and invigorate the spleen; Amomum villosum and Amomum cardamomum regulate qi and stimulate appetite; Perilla frutescens and Areca catechu regulate qi and relieve chest congestion; Bupleurum chinense soothes the liver; Artemisia argyi unblocks the meridians; and Cuscuta chinensis tonifies the kidneys. The entire formula addresses both the root cause and the symptoms, eliminating pathological products such as dampness, turbidity, and blood stasis, while restoring the spleen and stomach's digestive function and the circulation of qi and blood. It effectively blocks the generation of body odor at its source, and has a definite effect on eliminating halitosis, body odor, rusty smell, and fishy odor.

[0023] II. This invention uses an external umbilical patch as the primary form of drug delivery. Utilizing the direct connection between the umbilicus and the internal organs and meridians, the drug is absorbed through the umbilicus into the systemic circulation, effectively avoiding the first-pass metabolism and gastrointestinal burden of oral administration. It boasts high bioavailability and is particularly suitable for those with weak spleen and stomach, as well as the elderly. Furthermore, the composition can also be decocted in water, offering flexible administration. This invention is simple to prepare, safe, and non-toxic, and has promising application prospects.

[0024] The above overview is for illustrative purposes only and is not intended to be limiting in any way. Further aspects, embodiments, and features of the invention will become readily apparent from the following detailed description, in addition to the illustrative aspects, embodiments, and features described above. Detailed Implementation

[0025] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention.

[0026] The embodiments of the present invention will be described in detail below.

[0027] Example 1: Preparation of Traditional Chinese Medicine Composition Powder

[0028] Weigh out 15g of patchouli, 25g of agastache rugosa, 15g of atractylodes lancea, 10g of magnolia officinalis, 1g of amomum villosum, 10g of cardamom, 6g of perilla leaf, 6g of areca peel, 15g of bupleurum chinense, 15g of wormwood, and 10g of cuscuta chinensis. Dry them in a forced-air drying process at 45℃ until the moisture content is less than 8%. Mix and pulverize them, then pass them through a 100-mesh sieve to obtain the powder of the traditional Chinese medicine composition.

[0029] As an equivalent substitution for the above proportions, the following weight ranges can also be used: 10-20 parts of patchouli, 18-32 parts of agastache rugosa, 10-20 parts of atractylodes lancea, 5-15 parts of magnolia officinalis, 0.5-3 parts of amomum villosum, 5-15 parts of cardamom, 3-10 parts of perilla leaf, 3-10 parts of areca peel, 10-20 parts of bupleurum chinense, 10-20 parts of artemisia argyi, and 5-15 parts of cuscuta chinensis; the pulverized and sieved mesh can be selected between 80-200 mesh, all of which can achieve the purpose of this invention.

[0030] Example 2: Preparation of umbilical patch formulation

[0031] Take the powder of the traditional Chinese medicine composition obtained in Example 1, add petroleum jelly to it at a weight ratio of 1:1, and stir to mix evenly to form a paste. Take 3g of the paste and press it into a circular core layer 2 with a diameter of 2.5cm and a thickness of 0.5cm. Place the core layer 2 in the center of the medical non-woven fabric backing layer 1, and cover the core layer 2 with release paper as an anti-adhesion layer 3 to obtain the umbilical patch preparation.

[0032] As an equivalent alternative to the above preparation method, the pharmaceutically acceptable excipients may also be one or more of honey, glycerin, or vinegar; the weight ratio of the powder to the excipients may be adjusted between 1:0.5 and 1:2; the core layer 2 may also be pressed into a square shape, with a thickness between 0.2-1.0 cm and a weight between 1-5 grams; the backing layer 1 may also be medical breathable tape; the anti-adhesive layer 3 may also be polyester film; all of the above alternatives can produce umbilical patch preparations that meet the requirements for use.

[0033] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A traditional Chinese medicine composition for removing metabolic body odor, characterized in that, Made from the following parts by weight of active pharmaceutical ingredient: Patchouli 10-20 parts, Eupatorium fortunei 18-32 parts, Atractylodes lancea 10-20 parts, Magnolia officinalis 5-15 parts, Amomum villosum 0.5-3 parts, Amomum cardamomum 5-15 parts, Perilla frutescens 3-10 parts, Areca catechu 3-10 parts, Bupleurum chinense 10-20 parts, Artemisia argyi 10-20 parts, Cuscuta chinensis 5-15 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, Made from the following parts by weight of active pharmaceutical ingredient: Patchouli 15 parts, Eupatorium fortunei 25 parts, Atractylodes lancea 15 parts, Magnolia officinalis 10 parts, Amomum villosum 1 part, Amomum cardamomum 10 parts, Perilla frutescens 6 parts, Areca catechu 6 parts, Bupleurum chinense 15 parts, Artemisia argyi 15 parts, Cuscuta chinensis 10 parts.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The metabolic body odor includes one or more of the following: halitosis and body odor caused by spleen and stomach weakness, body odor caused by kidney essence deficiency, and body odor with a rusty or fishy smell caused by qi stagnation and blood stasis.

4. A umbilical patch preparation for removing metabolic body odor, characterized in that, It includes a core layer and a backing layer, wherein the core layer contains the traditional Chinese medicine composition according to claim 1 or 2.

5. The umbilical patch preparation according to claim 4, characterized in that, The core layer is made of the powder of the traditional Chinese medicine composition and pharmaceutically acceptable excipients; the pharmaceutically acceptable excipients include one or more of petrolatum, honey, glycerin, and vinegar.

6. The umbilical patch preparation according to claim 4, characterized in that, The core layer is circular or square in shape, with a thickness of 0.2-1.0 cm and a weight of 1-5 grams; the backing layer is medical non-woven fabric or medical breathable tape.

7. The use of the traditional Chinese medicine composition according to claim 1 in the preparation of a medicine for removing metabolic body odor.

8. The application according to claim 7, characterized in that, The drug is available in the form of an umbilical patch or an oral decoction.

9. A method for preparing an umbilical patch preparation for removing metabolic body odor, characterized in that, Includes the following steps: S1 Weigh each raw material according to the weight proportions described in claim 1 or 2, dry them, mix them evenly, pulverize them into fine powder, and sieve them. S2 Add pharmaceutically acceptable excipients to the fine powder obtained in step S1, mix evenly, and make a soft material or paste. S3. The soft material or paste obtained in step S2 is shaped into a core layer and placed on the backing layer to obtain the final product.

10. The preparation method according to claim 9, characterized in that, In step S1, the sieve mesh size is 80-200 mesh; in step S2, the pharmaceutically acceptable excipient is petrolatum, and the weight ratio of the fine powder to petrolatum is 1:0.5-1:2.