A traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof, which comprises prepared astragalus membranaceus, cassia twig, white peony root, dried ginger, jujube, prepared licorice, curcuma zedoaria, sparganium stoloniferum; the application also discloses a corresponding preparation method, wherein the prepared astragalus membranaceus, cassia twig, white peony root and prepared licorice are mixed, crushed and sieved to obtain base formula powder, dried ginger and jujube are separately crushed to obtain dried ginger powder and jujube powder, and the curcuma zedoaria and sparganium stoloniferum are mixed, crushed and sieved to obtain added medicine powder; the base formula powder, the dried ginger powder, the jujube powder and the added medicine powder are mixed to prepare medicine powder; a composite binder is prepared by using jujube and honey; finally, the composite binder and the medicine powder are mixed to prepare the traditional Chinese medicine composition; the astragalus membranaceus decoction is used as the basis, the sparganium stoloniferum and the curcuma zedoaria are added, the blood circulation is improved, the stomach pain of a patient is alleviated, the stomach mucosa is effectively repaired, the blood circulation of a local part is improved, the drug efficacy is promoted, and the stomach mucosa is repaired.

Description

Technical Field

[0001] This application relates to the field of pharmaceutical technology, specifically to a traditional Chinese medicine composition for treating chronic atrophic gastritis and its preparation method. Background Technology

[0002] Chronic atrophic gastritis is a common digestive system disease in clinical practice. Its core pathological feature is atrophy of the gastric mucosal glands. Clinical manifestations include upper abdominal pain, abdominal distension, belching, and loss of appetite. Among them, the spleen and stomach deficiency-cold type is one of the most common clinical syndromes. Its core pathogenesis is spleen and stomach weakness, internal generation of cold pathogens, and blood stasis caused by prolonged illness. The treatment should focus on warming the middle and strengthening the spleen, promoting blood circulation and removing blood stasis, and repairing the gastric mucosa. Summary of the Invention

[0003] The main purpose of this application is to provide a traditional Chinese medicine composition and preparation method for treating chronic atrophic gastritis, aiming to solve the shortcomings of the prior art in treating chronic atrophic gastritis of the spleen and stomach deficiency-cold type.

[0004] This application achieves the above objectives through the following technical solutions: A traditional Chinese medicine composition for treating chronic atrophic gastritis, comprising the following components by weight: 25-36 parts of roasted Astragalus membranaceus, 7-15 parts of Cinnamomum cassia, 20-28 parts of Paeonia lactiflora, 9-14 parts of dried ginger, 23-37 parts of jujube, 8-16 parts of roasted Glycyrrhiza uralensis, 10-14 parts of Curcuma zedoaria, and 8-14 parts of Sparganium stoloniferum.

[0005] Optionally, the traditional Chinese medicine composition comprises the following components by weight: 30 parts of roasted Astragalus membranaceus, 12 parts of Cinnamomum cassia, 24 parts of Paeonia lactiflora, 12 parts of dried ginger, 30 parts of jujube, 12 parts of roasted Glycyrrhiza uralensis, 12 parts of Curcuma zedoaria, and 12 parts of Sparganium stoloniferum.

[0006] Accordingly, this application also discloses a method for preparing the above-mentioned traditional Chinese medicine composition, including the following steps: The prepared astragalus root, cinnamon twig, white peony root, and prepared licorice root are mixed, pulverized, and sieved to obtain the basic formula powder; The dried ginger and jujubes were crushed separately and then sieved to obtain dried ginger powder and jujube powder. After mixing and pulverizing Curcuma zedoaria and Sparganium stoloniferum, the powdered medicine was obtained by sieving. The base powder, dried ginger powder, jujube powder, and flavored medicine powder are mixed to prepare a drug powder; A composite adhesive was prepared using jujubes and honey. The composite adhesive is mixed with drug powder to prepare a traditional Chinese medicine composition.

[0007] Optionally, the prepared astragalus root, cinnamon twig, white peony root, and prepared licorice root are mixed, pulverized, and sieved to obtain the basic formula powder, including the following steps: Prepare a mixture of roasted astragalus, cinnamon twig, white peony root, and roasted licorice root according to the formula; The mixture is pulverized using a pulverizer; The mixture is sieved using a screening machine, with a sieve mesh size of not less than 90 mesh.

[0008] Optionally, the dried ginger and jujubes are crushed separately and then sieved to obtain dried ginger powder and jujube powder. Prepare dried ginger and jujubes according to the recipe; The dried ginger is crushed and the powder is sieved to obtain dried ginger powder with a sieve mesh size of not less than 80 mesh.

[0009] Jujubes were frozen to prepare frozen jujubes; the freezing temperature was -15℃ to -10℃ and the freezing time was 25-30 minutes. Frozen jujubes are crushed by a pulverizer and the powder is sieved to obtain jujube powder with a sieve mesh size of not less than 80 mesh.

[0010] Optionally, the base powder, dried ginger powder, jujube powder, and flavoring powder are mixed to prepare a drug powder, including the following steps: Low-temperature ultraviolet sterilization was carried out on the basic formula powder, dried ginger powder, jujube powder and flavored medicine powder respectively. The sterilization temperature was 20-30℃, the ultraviolet intensity was 250-350μW / cm², and the sterilization time was 20-30min. The basic formula powder, dried ginger powder, jujube powder, and added medicine powder, which were sterilized at low temperature, were cooled to room temperature in the dark. The base powder, dried ginger powder, jujube powder, and flavored medicine powder are mixed in proportion to obtain the drug powder.

[0011] Optionally, a composite adhesive can be prepared using jujubes and honey, comprising the following steps: Take the reserved jujubes and purified water, and decoct them to prepare jujube extract; the decoction temperature is [temperature missing]. Prepare a mixture by mixing jujube extract with honey; Add roasted licorice powder to the mixture, wherein the amount of roasted licorice added is 0.4-0.7g; The mixture of liquid and roasted licorice powder is stirred evenly under heating conditions; the heating temperature is 55-65℃. The stirred mixture was cooled to room temperature to prepare a composite adhesive.

[0012] Optionally, the decoction temperature of the jujube extract is 50-60℃, and the decoction time is 20-30 minutes; the volume ratio of the jujube extract to honey is 1:(2-5).

[0013] Optionally, the traditional Chinese medicine composition is prepared by mixing the composite adhesive with the drug powder, including the following steps: The drug powder is placed in a pelleting machine and the composite adhesive is sprayed to prepare the first pellet, wherein the first stirring speed of the pelleting machine is 30-40 rpm and the diameter of the first pellet is 1-2 mm. A composite adhesive is sprayed onto the surface of the first pellet, and a second pellet is prepared at a second stirring speed of 35-45 rpm, wherein the diameter of the second pellet is 3-5 mm. The second pill was dried at low temperature to prepare a traditional Chinese medicine composition.

[0014] Optionally, the second pill is subjected to low-temperature drying to prepare a traditional Chinese medicine composition, including the following steps: The second pill was placed in a constant temperature drying oven and dried at a low temperature of 42-48℃ for 1-1.5 hours; the relative humidity inside the oven was 30%-40%. Adjust the temperature of the constant temperature drying oven to the second drying temperature; the second drying temperature is 52-58℃, and the drying time is 2-2.5 hours. Adjust the temperature of the constant temperature drying oven to the third drying temperature for drying; the third drying temperature is 28-32℃, and the drying time is 0.5-1h; The dried pills were sterilized by ultraviolet light, with an ultraviolet intensity of 300-400 μW / cm² and a sterilization time of 20-30 min.

[0015] Compared with the prior art, this application has the following beneficial effects: The traditional Chinese medicine composition described in this application, calculated by weight fraction, comprises 25-36 parts of roasted astragalus root, 7-15 parts of cinnamon twig, 20-28 parts of white peony root, 9-14 parts of dried ginger, 23-37 parts of jujube, 8-16 parts of roasted licorice root, 10-14 parts of turmeric, and 8-14 parts of sparganium. Correspondingly, this application also discloses a method for preparing the above-mentioned traditional Chinese medicine composition. First, roasted astragalus root, cinnamon twig, white peony root, and roasted licorice root are mixed and pulverized, then sieved to obtain a basic formula powder. Then, dried ginger and jujube are pulverized separately, sieved to obtain dried ginger powder and jujube powder. Next, turmeric and sparganium are mixed and pulverized, sieved to obtain a flavored medicine powder. Then, the basic formula powder, dried ginger powder, jujube powder, and flavored medicine powder are mixed to prepare a drug powder. Next, a composite binder is prepared using jujube and honey. Finally, the composite binder is mixed with the drug powder to prepare the traditional Chinese medicine composition. Compared with existing technologies, this application is based on the classic Huangqi Jianzhong Decoction, with the addition of Sparganium rhizome and Curcuma rhizome. In the whole formula, both Sparganium rhizome and Curcuma rhizome can break up blood stasis, promote qi circulation, eliminate stagnation and relieve pain, and have the function of promoting blood circulation and removing blood stasis. They can effectively promote the repair of gastric mucosa, thereby improving the patient's symptoms such as stomach pain, bloating and acid reflux in a short period of time. On this basis, it can improve local blood circulation, promote the efficacy of the medicine, and accelerate the repair of gastric mucosa, achieving a formula that addresses both the symptoms and the root cause. It is specifically used for chronic atrophic gastritis of the spleen and stomach deficiency-cold type and the mixed deficiency-excess type with blood stasis obstructing the stomach collaterals. Meanwhile, this application is based on Huangqi Jianzhong Decoction, which was created by Zhang Zhongjing to treat "deficiency and internal urgency, and various deficiencies". The formula uses astragalus, jujube and licorice to tonify the spleen and replenish qi, licorice root and ginger to warm yang and dispel cold, and white peony to relieve urgency and pain.

[0016] It is sweet and warm to strengthen the middle jiao and invigorate the spleen to generate essence; it strengthens the middle jiao and consolidates the exterior, and regulates and nourishes yin and yang. It is the main prescription for treating stomach pain caused by deficiency and cold.

[0017] Secondly, in the preparation process, this application adopts differentiated pulverization and non-destructive sterilization, so as to pulverize the different medicinal materials according to the direct compatibility and the condition of the medicinal materials themselves, so as to preserve the characteristics of the medicinal materials as much as possible. That is, the principal and assistant herbs are pulverized at the same time to ensure the full co-dissolution of astragalus polysaccharide, paeoniflorin and cinnamon twig volatile oil, and synergistic effect. Meanwhile, this application abandons honey as a single adhesive and instead uses a composite adhesive prepared from honey, jujube extract and roasted licorice powder. While taking into account the adhesive function, it can also work with the prescription to achieve the functions of tonifying the middle, harmonizing the medicine and protecting the stomach, which is conducive to improving the efficacy of the medicine. Attached Figure Description

[0018] Figure 1 A flowchart of a preparation method provided in Embodiment 2 of this application; Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0020] In this invention, unless otherwise explicitly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "fixed" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0021] Furthermore, if the embodiments of this invention involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. If the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0022] Implementation Method 1

[0023] This embodiment, as an optional embodiment of this application, discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis, comprising 25-36 parts of roasted astragalus, 7-15 parts of cinnamon twig, 20-28 parts of white peony root, 9-14 parts of dried ginger, 23-37 parts of jujube, 8-16 parts of roasted licorice root, 10-14 parts of turmeric, and 8-14 parts of sparganium rhizome. Furthermore, according to weight fractions, the traditional Chinese medicine composition includes 30 parts of roasted astragalus, 12 parts of cinnamon twig, 24 parts of white peony root, 12 parts of dried ginger, 30 parts of jujube, 12 parts of roasted licorice root, 12 parts of turmeric, and 12 parts of sparganium.

[0024] Implementation Method 2

[0025] This embodiment, as another optional embodiment of this application, discloses a method for preparing the above-mentioned traditional Chinese medicine composition, including the following steps: S1. Mix and pulverize the prepared Astragalus membranaceus, Cinnamomum cassia, Paeonia lactiflora and prepared Glycyrrhiza uralensis, and then sieve to obtain the basic formula powder; First, prepare a mixture of roasted astragalus, cinnamon twig, white peony root, and roasted licorice root according to the prescribed dosage; then, pulverize the mixture using a grinder; it should be noted that, considering the weight reduction caused by sieving later, the medicinal materials need to be prepared in excess. After pulverization, the mixture is sieved using a sieve to obtain the basic powder, with a sieve mesh size of not less than 90 mesh. Astragalus membranaceus (processed with honey), cinnamon twig, white peony root, and licorice root (processed with honey) are the principal and assistant herbs in this formula. They are the main components of Huangqi Jianzhong Decoction. By simultaneously pulverizing the above-mentioned principal and assistant herbs, the full co-dissolution of astragalus polysaccharides, paeoniflorin, and volatile oil of cinnamon twig can be effectively ensured, thus achieving synergistic effects. S2. Crush dried ginger and jujubes separately, and then sieve them to obtain dried ginger powder and jujube powder; Prepare dried ginger and jujubes according to the recipe. It should be noted that, considering the weight reduction caused by the later sieving, the medicinal materials need to be prepared in excess. The dried ginger is then put into a grinder to be ground, and then the ground ginger powder is sieved through a sieve to obtain dried ginger powder, wherein the sieve mesh number of the dried ginger powder is not less than 80 mesh. The jujubes were then placed in a freezing device for freezing treatment, with a freezing temperature of -15℃ to -10℃ and a freezing time of 25-30 minutes. The prepared frozen jujubes are placed in a pulverizer and pulverized. The pulverized powder is then sieved through a sieve to obtain jujube powder with a sieve mesh size of not less than 80 mesh.

[0026] Grinding dried ginger alone can effectively retain the loss of volatile warming components such as gingerol. At the same time, by freezing the jujubes before grinding, the freezing process can make the jujubes brittle, increase the powder yield during the grinding process, and make the grinding more thorough and the particles more uniform. Secondly, the lower temperature of the frozen jujubes can neutralize the heat generated by friction during the friction grinding process, thereby maximizing the retention of heat-sensitive effective components such as jujube polysaccharides and saponins. Meanwhile, during the freezing process, ice crystals can pierce cells, which can effectively increase the dissolution of jujube polysaccharides and thus mitigate the medicinal properties. S3. Mix Curcuma zedoaria and Sparganium stoloniferum, pulverize them, and sieve them to obtain the flavored medicine powder; Using the same method as in step S1, prepare the medicinal powders of Curcuma zedoaria and Sparganium stoloniferum, and then separate them into flavored medicinal powders.

[0027] S4. Mix the base powder, dried ginger powder, jujube powder and flavored medicine powder to prepare drug powder; The basic formula powder, dried ginger powder, jujube powder, and added medicine powder are placed into the ultraviolet sterilization device for low-temperature ultraviolet sterilization. The sterilization temperature is 20-30℃, the ultraviolet intensity is 250-350μW / cm², and the sterilization time is 20-30min. Subsequently, the basic formula powder, dried ginger powder, jujube powder and flavored medicine powder that have undergone low-temperature sterilization are placed in a room temperature environment and naturally cooled to room temperature in the dark. Weigh the base powder, dried ginger powder, jujube powder, and added medicinal powder according to the weight proportions of the formula, and mix the powders evenly to obtain the medicinal powder. Low-temperature sterilization can kill bacteria while avoiding the volatilization of heat-sensitive components such as astragalus, white peony, sparganium, and turmeric, thus maximizing the preservation of the effective components of the medicine and improving its efficacy.

[0028] S5. Prepare a composite adhesive using jujubes and honey; First, take jujubes and purified water, with the ratio of jujubes to purified water being 10g:50ml. Then, add the jujubes to the purified water and decoct them. After decoction, filter out the jujubes and take the filtrate as jujube extract. The decoction temperature for jujube extract is 50-60℃, and the decoction time is 20-30 minutes. Take jujube extract and honey. The honey needs to be filtered first, then softened at 50°C. The softened honey is then mixed with the jujube extract while stirring continuously to prepare a mixture. The volume ratio of the jujube extract to the honey is 1:(2-5). Take roasted licorice powder and then add it to the aforementioned mixture, wherein the amount of roasted licorice added is 0.4-0.7g; The mixture of the liquid and the roasted licorice powder is stirred evenly under heating conditions, wherein the heating temperature is 55-65℃; After stirring evenly, the mixture is placed at room temperature and allowed to cool naturally to room temperature to obtain the composite adhesive; In the composite adhesive, jujube has the effects of sweet and warm tonifying the middle, invigorating qi and strengthening the spleen, while roasted licorice has the effects of sweet and neutral tonifying qi and harmonizing the effects of various medicines. At the same time, honey has the effects of sweet and warm tonifying qi, moisturizing dryness and correcting taste. It is completely consistent with the compatibility concept of warming, tonifying, harmonizing and milding Huangqi Jianzhong Decoction. It also has a synergistic effect with the prepared Astragalus membranaceus in the formula, which can effectively enhance the effect of invigorating Qi and strengthening the spleen, making the Qi-tonifying effect stronger and more lasting, fundamentally improving the symptoms of spleen and stomach Qi deficiency, aversion to cold and fatigue, and abdominal distension after meals; at the same time, it works synergistically with the assistant herbs such as Cinnamomum cassia to solve the problem of Cinnamomum cassia and dried ginger being too warm and dry, avoiding damage to Yin by long-term use, and achieving the effects of warming the middle and dispelling cold, protecting the stomach and relieving pain; and its synergistic effect with Paeonia lactiflora can significantly relieve the dull pain, distending pain, spasm and discomfort in the stomach, making the pain relief faster, gentler and non-addictive. Synergistic effects with Sparganium and Curcuma can invigorate qi and strengthen the body, thus ensuring the effects of Sparganium and Curcuma on improving microcirculation and repairing gastric mucosa, while avoiding their effects of damaging qi and irritating the spleen and stomach. Finally, compared with traditional single honey, it has better binding effect and stronger stability, which can ensure the regulation of pill disintegration time, achieve stable drug dissolution, and achieve long-lasting efficacy.

[0029] S6. The composite adhesive is mixed with the drug powder to prepare a traditional Chinese medicine composition.

[0030] The drug powder is placed in a pelleting machine, and the pellets are rotated at a first stirring speed. At the same time, the composite adhesive is sprayed onto the surface of the drug powder. The first pellet is prepared during rotation. The first stirring speed of the pelleting machine is 30-40 rpm, and the diameter of the first pellet is 1-2 mm. After the first pellet is prepared, the speed of the pellet mill is adjusted to the second stirring speed, and the composite binder is sprayed onto the surface of the first pellet. The second pellet is prepared at the second stirring speed, which is 35-45 rpm, and the diameter of the second pellet is 3-5 mm. After the second pill is prepared, it is transferred to a constant temperature drying oven and dried at a low temperature of 42-48℃ for 1-1.5 hours; the relative humidity inside the oven is 30%-40%. After the first stage of drying is completed, adjust the temperature of the constant temperature drying oven to the second drying temperature; the second drying temperature is 52-58℃, and the drying time is 2-2.5h; After the second stage of drying is completed, adjust the temperature of the constant temperature drying oven to the third drying temperature, which is 28-32℃, and the drying time is 0.5-1h. Finally, the dried pills are removed and sterilized with ultraviolet light to obtain the traditional Chinese medicine composition. The ultraviolet light intensity is 300-400 μW / cm², and the sterilization time is 20-30 min.

[0031] By using a phased, temperature-controlled, humidity-controlled, and wind-speed-controlled method, the pills are dehydrated simultaneously inside and out, preventing cracking, collapse, deformation, and damage to the ingredients. This fundamentally solves the problems that traditional high-temperature drying methods often cause, such as cracking, shrinkage, sanding, ingredient degradation, and poor taste. When the pills are first formed, they have high internal moisture and a soft structure. The first stage of drying can achieve slow dehydration of the surface, slight hardening, and the formation of a stable skeleton, laying the foundation for subsequent deep dehydration, thereby achieving stable shape and avoiding defects such as collapse and adhesion. The second stage is the accelerated dehydration stage, which causes the internal moisture to migrate outwards quickly. At this time, since the shape is relatively stable, the temperature can be appropriately increased to promote the rate of moisture diffusion and thus improve the dehydration efficiency, thereby achieving uniform drying inside and out. At the same time, low-temperature drying can effectively prevent the denaturation of heat-sensitive and easily oxidized components in the pills, thus ensuring the efficacy of the pills; The third stage of drying is the low-temperature shaping stage, which involves slowly cooling the pills at a lower temperature to balance the moisture and stabilize the pill structure. Compared with existing technologies, this application is based on the classic Huangqi Jianzhong Decoction, with the addition of Sparganium rhizome and Curcuma rhizome. In the whole formula, Sparganium rhizome and Curcuma rhizome have the function of promoting blood circulation and removing blood stasis, which can effectively promote the repair of gastric mucosa, thereby improving the patient's symptoms such as stomach pain, bloating, and acid reflux in a short period of time. On this basis, it improves local blood circulation, promotes the efficacy of the medicine, and accelerates the repair of gastric mucosa, achieving a formula that addresses both the symptoms and the root cause. It is specifically used for chronic atrophic gastritis of the spleen and stomach deficiency-cold type. Meanwhile, this application is based on Huangqi Jianzhong Decoction, and the Chinese medicine preparations described herein are mild in nature and have no toxic side effects; Secondly, in the preparation process, this application adopts differentiated pulverization and non-destructive sterilization, so as to pulverize the different medicinal materials according to the direct compatibility and the condition of the medicinal materials themselves, so as to preserve the characteristics of the medicinal materials as much as possible. That is, the principal and assistant herbs are pulverized at the same time to ensure the full co-dissolution of astragalus polysaccharide, paeoniflorin and cinnamon twig volatile oil, and synergistic effect. Meanwhile, this application abandons honey as a single adhesive and instead uses a composite adhesive prepared from honey, jujube extract and roasted licorice powder. While taking into account the adhesive function, it can also work with the prescription to achieve the functions of tonifying the middle, harmonizing the medicine and protecting the stomach, which is conducive to improving the efficacy of the medicine.

[0032] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A traditional Chinese medicine composition for treating chronic atrophic gastritis, characterized in that, The formula, by weight, includes the following components: 25-36 parts of roasted astragalus, 7-15 parts of cinnamon twig, 20-28 parts of white peony root, 9-14 parts of dried ginger, 23-37 parts of jujube, 8-16 parts of roasted licorice root, 10-14 parts of turmeric, and 8-14 parts of sparganium rhizome.

2. The traditional Chinese medicine composition for treating chronic atrophic gastritis according to claim 1, characterized in that, The formula, by weight, includes the following components: 30 parts of roasted astragalus, 12 parts of cinnamon twig, 24 parts of white peony root, 12 parts of dried ginger, 30 parts of jujube, 12 parts of roasted licorice root, 12 parts of turmeric, and 12 parts of sparganium rhizome.

3. A method for preparing a traditional Chinese medicine composition for treating chronic atrophic gastritis according to claims 1 and 2, characterized in that, Includes the following steps: The prepared astragalus root, cinnamon twig, white peony root, and prepared licorice root are mixed, pulverized, and sieved to obtain the basic formula powder; The dried ginger and jujubes were crushed separately and then sieved to obtain dried ginger powder and jujube powder. After mixing and pulverizing Curcuma zedoaria and Sparganium stoloniferum, the powdered medicine was obtained by sieving. The base powder, dried ginger powder, jujube powder, and flavored medicine powder are mixed to prepare a drug powder; A composite adhesive was prepared using jujubes and honey. The composite adhesive is mixed with drug powder to prepare a traditional Chinese medicine composition.

4. The preparation method according to claim 3, characterized in that, The process of mixing and pulverizing roasted astragalus, cinnamon twig, white peony root, and roasted licorice root, followed by sieving to obtain the basic formula powder, includes the following steps: Prepare a mixture of roasted astragalus, cinnamon twig, white peony root, and roasted licorice root according to the formula; The mixture is pulverized using a pulverizer; The mixture is sieved using a screening machine, with a sieve mesh size of not less than 90 mesh.

5. The preparation method according to claim 3, characterized in that, The dried ginger and jujubes are crushed separately and then sieved to obtain dried ginger powder and jujube powder. Prepare dried ginger and jujubes according to the recipe; The dried ginger is crushed and the powder is sieved to obtain dried ginger powder with a sieve mesh size of not less than 80 mesh. Jujubes were frozen to prepare frozen jujubes; the freezing temperature was -15℃ to -10℃ and the freezing time was 25-30 minutes. Frozen jujubes are crushed by a pulverizer and the powder is sieved to obtain jujube powder with a sieve mesh size of not less than 80 mesh.

6. The preparation method according to claim 3, characterized in that, The preparation of the drug powder by mixing the base powder, dried ginger powder, jujube powder, and flavoring powder includes the following steps: Low-temperature ultraviolet sterilization was carried out on the basic formula powder, dried ginger powder, jujube powder and flavored medicine powder respectively. The sterilization temperature was 20-30℃, the ultraviolet intensity was 250-350μW / cm², and the sterilization time was 20-30min. The basic formula powder, dried ginger powder, jujube powder, and added medicine powder, which were sterilized at low temperature, were cooled to room temperature in the dark. The base powder, dried ginger powder, jujube powder, and flavored medicine powder are mixed in proportion to obtain the drug powder.

7. The preparation method according to claim 3, characterized in that, The preparation of the composite adhesive using jujubes and honey includes the following steps: Take the reserved jujubes and purified water, and decoct them to prepare jujube extract; the decoction temperature is [temperature missing]. Prepare a mixture by mixing jujube extract with honey; Add roasted licorice powder to the mixture, wherein the amount of roasted licorice added is 0.4-0.7g; The mixture of liquid and roasted licorice powder is stirred evenly under heating conditions; the heating temperature is 55-65℃. The stirred mixture was cooled to room temperature to prepare a composite adhesive.

8. The preparation method according to claim 7, characterized in that, The jujube extract is decocted at a temperature of 50-60℃ for 20-30 minutes; the volume ratio of the jujube extract to honey is 1:(2-5).

9. The preparation method according to claim 3, characterized in that, The preparation of the traditional Chinese medicine composition by mixing the composite adhesive with the drug powder includes the following steps: The drug powder is placed in a pelleting machine and the composite adhesive is sprayed to prepare the first pellet, wherein the first stirring speed of the pelleting machine is 30-40 rpm and the diameter of the first pellet is 1-2 mm. A composite adhesive is sprayed onto the surface of the first pellet, and a second pellet is prepared at a second stirring speed of 35-45 rpm, wherein the diameter of the second pellet is 3-5 mm. The second pill was dried at low temperature to prepare a traditional Chinese medicine composition.

10. The preparation method according to claim 9, characterized in that, The process of drying the second pill at low temperature to prepare the traditional Chinese medicine composition includes the following steps: The second pill was placed in a constant temperature drying oven and dried at a low temperature of 42-48℃ for 1-1.5 hours; the relative humidity inside the oven was 30%-40%. Adjust the temperature of the constant temperature drying oven to the second drying temperature; the second drying temperature is 52-58℃, and the drying time is 2-2.5 hours. Adjust the temperature of the constant temperature drying oven to the third drying temperature for drying; the third drying temperature is 28-32℃, and the drying time is 0.5-1h; The dried pills were sterilized by ultraviolet light, with an ultraviolet intensity of 300-400 μW / cm² and a sterilization time of 20-30 min.

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