A composition with deodorizing and itching relieving effects and its use in the preparation of a feminine pad

Abstract

The application provides a composition with deodorization and itching relief effects, which comprises the following components in parts by mass: sodium chlorite 60-75 parts, Paris extract 1.5-5 parts, konjac powder 3-8 parts, citric acid 1-4 parts, and nano zinc oxide 0.5-1.5 parts. The composition is coated on a sanitary pad to prepare a female sanitary pad. The female sanitary pad composition of the application is based on a combination of a chlorine dioxide slow-release system and Paris extract, and solves the problems of strong chemical irritation, insufficient itching relief effect, poor odor control and the like of existing female sanitary pad products through synergistic antibacterial, itching relief and microenvironment regulation.

Description

Technical Field

[0001] This invention belongs to the field of feminine hygiene products technology, specifically relating to a composition with deodorizing and antipruritic effects and its application in the preparation of feminine panty liners. Background Technology

[0002] As a daily hygiene product, feminine panty liners are increasingly valued for their antibacterial, odor-eliminating, and comfort properties. Current technologies often rely on chemical disinfectants or single plant extracts in the design of the functional layers of panty liners, but these technologies still suffer from the following significant drawbacks: 1. The irritant risks of chemical disinfectants. Mainstream products use chlorine-containing compounds (such as sodium hypochlorite and calcium chlorate) or quaternary ammonium salt bactericides. While these can achieve basic antibacterial effects, their strong oxidizing properties can easily damage the skin barrier. Clinical studies have shown that long-term exposure to these ingredients can lead to mucosal redness and itching (e.g., irritation level 2 in Comparative Example 4), and residual chlorinated organic compounds (such as chloroform) pose a carcinogenic risk. Furthermore, existing disinfectants only focus on sterilization and lack sufficient adsorption capacity for odors such as ammonia and hydrogen sulfide, failing to address the continuous release of volatile odors in humid environments.

[0003] 2. Bottlenecks in the application of chlorine dioxide (ClO2) technology. Although chlorine dioxide, as a broad-spectrum and safe disinfectant, is recommended by the WHO for use in the medical field, its application in panty liners still faces two major challenges: First, traditional solid-liquid reaction systems (such as chlorite + strong acid) release too quickly, easily causing local ClO2 concentrations to exceed the standard (>500 ppm irritates the respiratory tract); second, existing formulations lack specific inhibition against fungal infections, with a kill rate of less than 80% against itchy pathogens such as Candida albicans (data from Comparative Example 2), failing to meet the needs of female vaginal microecological balance.

[0004] 3. Limitations of the efficacy of plant-based active ingredients. Plant-based antibacterial agents, such as honeysuckle and artemisia extracts, can alleviate chemical irritation, but their mechanisms of action are singular. For example, while saponins in Paris polyphylla extract have antifungal potential, they are easily deactivated by the storage environment of sanitary pads (humidity > 60%) when added directly, and their compatibility with chemical disinfectants is poor, often leading to component layering or negation of efficacy (comparative example 3's odor removal effect is only 24 hours).

[0005] 4. Lack of dynamic regulation and long-lasting sustained-release technology. Most existing panty liners use a static sterilization design, which cannot adjust the ClO2 release rate in real time according to the usage environment (such as changes in temperature and humidity). This results in a "pulse-like" defect, where the initial concentration is too high and the antibacterial effect fails later. At the same time, most products neglect the active regulation of the pH value of the private parts (healthy range 4.5-5.5). An alkaline environment can easily promote the proliferation of pathogens, exacerbating odor and the risk of infection.

[0006] Existing products on the market have failed to overcome the triangular contradiction of "efficiency-safety-comfort": the chemical incompatibility between chlorine-containing disinfectants and herbal ingredients, the physical conflict between slow-release materials and microenvironment regulation, and the biological contradiction between short-term antibacterial effect and long-term ecological balance. These factors prevent products from meeting women's core needs for long-lasting, safe antibacterial action, root-cause itch relief, and microecological self-regulation. Therefore, it is necessary to design a composition with odor-removing and itch-relieving effects and its application in the preparation of feminine hygiene pads. Summary of the Invention

[0007] The purpose of this invention is to provide To achieve the above objectives, the present invention provides the following technical solution: A composition with deodorizing and antipruritic effects, comprising, by weight, the following components: 60-75 parts sodium chlorite, 1.5-5 parts Paris polyphylla extract, 3-8 parts konjac powder, 1-4 parts citric acid, and 0.5-1.5 parts nano zinc oxide.

[0008] The Paris polyphylla extract (Yunnan Baiyao Group) is extracted using supercritical CO2 extraction, and the total saponin content in the Paris polyphylla extract is ≥40%.

[0009] The mass ratio of konjac powder (Hubei Yizhi Konjac Biotechnology) to citric acid (Shanghai Maclean) is 2:1.

[0010] The konjac powder is acetylated and modified with a degree of substitution ≥0.8.

[0011] The mass ratio of the nano zinc oxide to the Paris polyphylla extract is 1:(3-5).

[0012] The sodium chlorite (Aladdin) has a purity of ≥80%, and the sodium chlorite is slowly released by being coated with konjac powder.

[0013] The nano zinc oxide (Jiangsu Xianfeng Nano) has a particle size ≤50nm and a specific surface area ≥50m². 2 / g.

[0014] The composition also includes, by weight, 0.1-0.5 parts of menthol.

[0015] Application of a composition having deodorizing and antipruritic effects, said composition being applied to a panty liner for the preparation of feminine panty liners.

[0016] The base material of the pad is a breathable non-woven fabric (Guangdong Bidefu), the weight of the breathable non-woven fabric is 25g / m2, and the surface of the breathable non-woven fabric is coated with hydroxyethyl cellulose colloid (Shanghai Aladdin) with a viscosity ≥2000 mPa·s.

[0017] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: 1. The preparation process of Paris polyphylla extract in this application adopts supercritical CO2 extraction technology, with a total saponin content of ≥40%, ensuring the purity of active ingredients.

[0018] 2. This application controls the ClO2 release rate to 0.1-0.3 mg / h·cm by coating sodium chlorite with konjac flour. 2 To avoid a sudden increase in concentration that could cause fungal stress and escape.

[0019] 3. The compound system of Paris polyphylla saponins and chlorine dioxide (ClO2) in this application achieves enhanced antibacterial efficacy through dual-target action. The saponins in the Paris polyphylla extract enhance the penetration efficiency of ClO2 against Candida albicans by disrupting the sterol structure of the fungal cell membrane; ClO2 further oxidizes the fungal mitochondrial enzyme system, blocking energy metabolism. The synergistic effect of the two not only increases the antibacterial rate from 85% to 99.2%, but also significantly reduces fungal drug resistance (resistance rate <5%).

[0020] 4. The nano zinc oxide in this application has a specific surface area ≥ 50 m² / g, which enhances its binding ability with skin lipids; the mass ratio of nano zinc oxide to Paris polyphylla extract is 1:3-1:5, which avoids the charge repulsion between metal ions and saponins.

[0021] 5. The nano-zinc oxide (particle size ≤50nm) in this application, combined with menthol, forms a transdermal synergistic network. The nano-zinc oxide penetrates into the dermis through the stratum corneum interstitial space, inhibiting histamine release; menthol activates transient receptor potential (TRPM8) channels, blocking pruritus signal transduction. The synergistic effect of the two prolongs the antipruritic effect to 12 hours, with a transdermal absorption rate ≥90%.

[0022] 6. The acetylated konjac powder in this application has a degree of substitution ≥0.8, which enhances the pH buffering capacity; the molar ratio of konjac powder to citric acid is 2:1, which precisely matches the needs of vaginal microenvironment regulation.

[0023] 7. The konjac flour-citric acid system of this application maintains a pH of 5.0-5.8 through an ion exchange buffer mechanism. Excessive H⁺ is complexed by glucomannan in the konjac flour, and citric acid slowly releases acidic groups, forming a dynamic equilibrium. This environment inhibits the proliferation of pathogenic bacteria (such as Gardnerella vaginalis) while promoting the colonization of lactobacilli, increasing bacterial abundance by 3.2 times.

[0024] 8. In practical applications, the composite design of the breathable nonwoven fabric substrate and hydroxyethyl cellulose colloid in this application achieves intelligent regulation of dryness and moisture: In high humidity environments (such as sweating during exercise): the colloid absorbs excess water and swells, releasing ClO2 to inhibit anaerobic bacteria; in dry environments: the konjac powder water-locking film reduces transepidermal water loss (TEWL decreases by 37%), preventing skin cracking.

[0025] 9. This application has antifungal specificity: it inhibits β-glucan synthase of Candida albicans on two targets, breaking through the bottleneck of single-target resistance of traditional azole drugs.

[0026] 10. The thermoplastic molding properties of the acetylated konjac powder (degree of substitution ≥0.8) of this application are compatible with existing sanitary pad production lines, requiring no additional equipment investment.

[0027] 11. This application is based on a panty liner composition formulated with a chlorine dioxide sustained-release system and Paris polyphylla extract. Through synergistic antibacterial, antipruritic, and microenvironmental regulation, it solves the problems of strong chemical irritation, insufficient antipruritic effect, and poor odor control in existing feminine panty liners. Detailed Implementation

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0029] A composition with deodorizing and antipruritic effects, comprising, by weight, the following components: 60-75 parts sodium chlorite, 1.5-5 parts Paris polyphylla extract, 3-8 parts konjac powder, 1-4 parts citric acid, and 0.5-1.5 parts nano zinc oxide.

[0030] The Paris polyphylla extract (Yunnan Baiyao Group) is extracted using supercritical CO2 extraction, and the total saponin content in the extract is ≥40%. Traditional ethanol reflux extraction destroys heat-sensitive saponins at high temperatures (>60℃), resulting in a total saponin content of only 25%. This invention employs supercritical CO2 extraction (critical temperature 31.3℃, pressure 7.4 MPa), selectively dissolving saponins at low temperatures (polarity matching), avoiding thermal degradation, achieving a total saponin content ≥40%, and increasing the purity of active ingredients by 60%.

[0031] The mass ratio of konjac powder (Hubei Yizhi Konjac Biotechnology) to citric acid (Shanghai Maclean) is 2:1.

[0032] The konjac powder is acetylated to a degree of substitution ≥0.8. Unmodified konjac powder has a degree of substitution of 0.2 and a lower pH buffering capacity (fluctuating between 3.9 and 6.5). The glucomannan backbone of the acetylated konjac powder of this invention is complexed with H+ via -O-CO-CH3 groups. + Combined with the dynamic release of H from citric acid +Maintaining a pH of 5.0-5.8 inhibits Gardnerella vaginalis (proliferation occurs at pH > 5.5). Furthermore, unmodified konjac flour (Comparative Example 2) has a thermoplastic temperature > 180℃, incompatible with sanitary pad production lines (commonly 150℃). This application uses acetylated konjac flour (degree of substitution ≥ 0.8), which lowers the glass transition temperature (Tg) to 120-140℃, allowing for direct hot pressing without additional equipment investment.

[0033] The mass ratio of the nano zinc oxide to the Paris polyphylla extract is 1:(3-5).

[0034] The sodium chlorite (Aladdin) has a purity of ≥80%, and is released slowly by being coated with konjac powder. In existing technologies, the release rate of sodium chlorite directly reaches 0.68 mg / h·cm⁻¹. 2 A sudden increase in concentration can easily trigger fungal stress escape (increased drug resistance). The acetylated konjac powder of this invention (degree of substitution ≥0.8) coats sodium chlorite through a β-1,4 glycosidic bond network, forming a hydrogen bond controlled-release channel, with a stable ClO2 release rate of 0.1-0.3 mg / h·cm⁻¹. 2 It inhibits fungal escape (resistance rate <5%).

[0035] The nano zinc oxide (Jiangsu Xianfeng Nano) has a particle size ≤50nm and a specific surface area ≥50m². 2 / g.

[0036] The composition, by weight, also includes the following component: 0.1-0.5 parts of menthol. Existing technologies using a single antipruritic ingredient (such as menthol) have short-lasting effects (<6 hours). The present invention utilizes nano-zinc oxide (0.5-1.5 parts) to penetrate the dermis and inhibit histamine release, while menthol (0.1-0.5 parts) activates the TRPM8 channel to block itch signals, synergistically prolonging the antipruritic effect to 12 hours.

[0037] Application of a composition having deodorizing and antipruritic effects, said composition being applied to a panty liner for the preparation of feminine panty liners.

[0038] The base material of the pad is a breathable nonwoven fabric (Guangdong Bidefu), with a basis weight of 25 g / m². The surface of the breathable nonwoven fabric is coated with hydroxyethyl cellulose colloid (Shanghai Aladdin), with a viscosity ≥2000 mPa·s. Ordinary nonwoven fabric (basis weight >30 g / m²) is also used. 2 The original fabric had poor breathability and could not dynamically regulate humidity. The present invention uses a breathable nonwoven fabric coated with hydroxyethyl cellulose colloid, which swells and releases ClO2 (increased antibacterial rate) under high humidity, and forms a water-locking film with konjac powder when drying.

[0039] The present application will be further described below with reference to specific embodiments and analysis and testing.

[0040] Example 1 A composition with deodorizing and antipruritic effects, comprising, by weight, the following components: 60 parts sodium chlorite, 3 parts Paris polyphylla extract, 6 parts konjac powder, 3 parts citric acid, 1 part nano zinc oxide, and 0.3 parts menthol. The Paris polyphylla extract is extracted using supercritical CO2 extraction, and the total saponin content in the extract is ≥40%. The konjac powder is acetylated and modified with a degree of substitution ≥0.8. The sodium chlorite has a purity ≥80%, and is released slowly through coating with konjac powder. The nano zinc oxide has a particle size ≤50 nm and a specific surface area ≥50 m² / g. 2 / g.

[0041] Example 2 In this embodiment, the similarities with those in Example 1 will not be repeated, and the differences are as follows: A composition with deodorizing and antipruritic effects, by weight, the composition includes the following components: 70 parts sodium chlorite, 5 parts Paris polyphylla extract, 8 parts konjac powder, 4 parts citric acid, 1.5 parts nano zinc oxide, and 0.5 parts menthol.

[0042] Example 3 In this embodiment, the similarities with those in Example 1 will not be repeated, and the differences are as follows: A composition with deodorizing and antipruritic effects, by weight, the composition includes the following components: 75 parts sodium chlorite, 1.5 parts Paris polyphylla extract, 3 parts konjac powder, 1.5 parts citric acid, 0.5 parts nano zinc oxide, and 0.1 parts menthol.

[0043] Comparative Example 1 In this comparative example, the similarities with those in Example 1 will not be repeated, and the differences are as follows: the Paris polyphylla extract was prepared by ethanol reflux method (total saponin content 25%).

[0044] Comparative Example 2 In this comparative example, the similarities with those in Example 1 will not be repeated, and the differences are as follows: the konjac powder is not acetylated (degree of substitution 0.2), and the mass ratio of citric acid to konjac powder is 1:1;

[0045] Comparative Example 3 In this comparative example, the similarities with those in Example 1 will not be repeated, and the differences are as follows: the sodium chlorite was not coated with konjac powder for slow release;

[0046] Comparative Example 4 In this comparative example, the similarities with Example 1 will not be repeated, and the differences are as follows: the nano zinc oxide particle size is 200 nm (specific surface area 10 m²). 2 / g);

[0047] Comparative Example 5 In this comparative example, the similarities with those in Example 1 will not be repeated, but the differences are as follows: the composition does not contain menthol.

[0048] Example and comparative analysis test results The testing method described in this application is as follows: The following are standardized methodologies for each test metric, with the test methods and their basis explained in the following order: 1. Total saponin content test Methodology: Referencing the 2020 edition of the Chinese Pharmacopoeia, Part IV, General Chapter 0401, Ultraviolet-Visible Spectrophotometry, the specific steps are as follows: Preparation of standard curve: Prepare a gradient solution of 0.1-1.0 mg / mL using Paris polyphylla saponin standard (Sigma, purity ≥98%), add 0.5 mL of 5% vanillin-glacial acetic acid solution and 0.8 mL of perchloric acid, heat in a water bath at 70℃ for 15 minutes, and measure the absorbance at 560 nm after cooling to plot the standard curve (R²≥0.995).

[0049] Sample preparation: Take 50 mg of Paris polyphylla extract from the composition, extract with ethanol by sonication for 30 minutes, centrifuge to collect the supernatant, and develop color according to the standard curve procedure.

[0050] Calculation: The total saponin content was calculated using the standard curve regression equation, and the average value was taken from three parallel determinations.

[0051] 2. ClO2 release rate test Method based on: Modified method of ASTM F3139-15 "Determination of the release rate of slow-release chlorine dioxide gas", specific steps: Apparatus: Apply the composition to the pad (10 cm) 2 Afterwards, place it in a closed diffusion cell (at a constant temperature of 25℃), and connect the outlet to an absorption bottle (containing 10 mL of 0.1 mol / L KI solution).

[0052] Collection and titration: Take a sample once per hour, and titrate the absorbent solution with 0.01 mol / L Na2S2O3 standard solution until it is colorless, and record the volume consumed.

[0053] Calculation: Calculate the ClO2 release rate using the formula: Release rate = A × tV × C × 13.49 (mg / h·cm²) (V: titration volume / mL; C: sodium thiosulfate concentration / mol / L; A: pad area / cm²) 2 t: time / h).

[0054] 3. Candida albicans inhibition rate test Method based on: CLSI M27-A3 microdilution method, specific steps: Preparation of bacterial suspension: Candida albicans ATCC 90028 was inoculated into Sabouraud broth and incubated at 35°C for 24 hours, then adjusted to 1×10⁻⁶. 6 CFU / mL.

[0055] Drug action: The extract of the composition (physiological saline, extracted at 37°C for 24 hours) was diluted in a two-fold serial manner and mixed with an equal volume of bacterial suspension, and incubated at 35°C for 48 hours.

[0056] Endpoint determination: The lowest concentration with no visible colony growth is taken as the MIC value, and the inhibition rate is calculated as follows: Inhibition rate = (1 - number of colonies in the blank control group and number of colonies in the experimental group) × 100%.

[0057] 4. Drug resistance rate test Methodology based on: CLSI M27-A3 Appendix D "Fungal Resistance Induction Tests", specific steps: Subculture: Candida albicans was co-cultured with a combination extract at a sub-inhibitory concentration (1 / 2 MIC), and fresh culture medium was transferred daily for 20 consecutive subcultures.

[0058] Drug resistance testing: The MIC value of the 20th generation strain was measured. The drug resistance rate was calculated as follows: Drug resistance rate = Initial MIC value / MIC value after subculturing × 100% (a drug resistance rate ≥ 4 times the initial MIC was considered a drug-resistant strain).

[0059] 5. Transdermal absorption rate test Methodology: Franz diffusion cell method (refer to OECD TG 428), specific steps: Skin model: Ex vivo pig skin (0.8 mm thick, for pre-verification of integrity) was taken and fixed in a Franz cell (receiving solution was pH 7.4 PBS, 32°C circulating water bath).

[0060] Administration and sampling: The composition containing 0.5% fluorescently labeled nano zinc oxide was applied to the skin surface (dose 2 mg / cm²). 2 Samples were taken at 0.5, 1, 2, 4, 8, and 12 hours, and the concentration of nano zinc oxide in the receiving solution was determined by HPLC.

[0061] Calculation: Transdermal absorption rate = Cumulative permeation volume / Total dosage × 100%.

[0062] 6. Test on the fold increase in bacterial abundance Methodology: 16S rRNA gene qPCR quantification (refer to ISO 17601:2016), specific steps: Sample processing: Take simulated vaginal flora samples after using the composite pad and extract total DNA.

[0063] Quantitative analysis: The copy number of Lactobacillus was calculated using the standard curve method. The increase in bacterial abundance was calculated as: experimental group copy number / control group copy number.

[0064] Table 1 Analysis of Test Results

[0065] The test results are shown in Table 1. From Table 1, we can see that Examples 1-3 retained heat-sensitive saponins through supercritical CO2 extraction, with a total saponin content of ≥40%; while Comparative Example 1 used the ethanol reflux method (high temperature destroys activity), with a content of only 25.7%, which verifies the protective advantage of supercritical technology for active ingredients.

[0066] The ClO2 release rate in Example 1 was 0.25 mg / h·cm. 2 The release rate of Comparative Example 3 (uncoated) reached 0.68 mg / h·cm⁻¹. 2 This indicates that the acetylation modification of konjac flour (degree of substitution ≥ 0.8) delays the release of ClO2 through the hydrogen bond network, thus avoiding a sudden increase in concentration.

[0067] The antibacterial rate of Example 1 (99.2%) was significantly higher than that of Comparative Example 1 (85.3%), because Paris polyphylla saponins disrupt the fungal cell membrane 3 and enhance the penetration efficiency of ClO2; while the resistance rate was <5% (comparative Example 1 reached 22.6%), indicating that the dual-target action (saponin + ClO2) can avoid single-target resistance.

[0068] Example 1: The transdermal absorption rate of 92.1% is attributed to the small particle size (≤50nm) and high specific surface area (≥50m²) of nano-zinc oxide. 2 The absorbance of the control group (particle size 200 nm) was 70.2%, while the absorbance of the control group (particle size 200 nm) was only 70.2%, indicating that the nanoscale directly affects the permeability of the stratum corneum.

[0069] The pH of Example 1 was stable at 5.2-5.5 because the acetylated konjac flour (degree of substitution ≥0.8) and citric acid formed a dynamic buffer at a 2:1 molar ratio, while the pH of Comparative Example 2 (unacetylated) fluctuated from 3.9 to 6.5, resulting in an increase in bacterial abundance of only 1.8 times (3.5 times in Example 1).

[0070] Example 1 demonstrated the best overall performance, validating the effectiveness of the design combining supercritical CO2 extraction, slow-release coating of konjac flour, and synergistic effects of nano-zinc oxide and menthol. Comparative data showed that deviations from any key parameter (such as extraction process, component ratio, or material modification) led to a significant decrease in performance, highlighting the innovation and necessity of the technical solution presented in this invention.

[0071] The technical solution of this invention systematically solves the contradictions between antibacterial, antipruritic, safety and cost in the field of feminine pads through ingredient innovation and parameter optimization, and has clear clinical value and market competitiveness.

[0072] The above description represents the preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A composition having deodorizing and antipruritic effects, characterized in that, The composition comprises, by weight, the following components: 60-75 parts sodium chlorite, 1.5-5 parts Paris polyphylla extract, 3-8 parts konjac flour, 1-4 parts citric acid, and 0.5-1.5 parts nano zinc oxide.

2. The composition with deodorizing and antipruritic effects according to claim 1, characterized in that: The Paris polyphylla extract is extracted by supercritical CO2 extraction, and the total saponin content in the Paris polyphylla extract is ≥40%.

3. The composition with deodorizing and antipruritic effects according to claim 1, characterized in that: The mass ratio of konjac powder to citric acid is 2:

1.

4. The composition with deodorizing and antipruritic effects according to claim 3, characterized in that: The konjac powder is acetylated and modified with a degree of substitution ≥0.

8.

5. The composition with deodorizing and antipruritic effects according to claim 1, characterized in that: The mass ratio of the nano zinc oxide to the Paris polyphylla extract is 1:(3-5).

6. The composition with deodorizing and antipruritic effects according to claim 1, characterized in that: The sodium chlorite has a purity of ≥80%, and the sodium chlorite is slowly released by being coated with konjac powder.

7. The composition with deodorizing and antipruritic effects according to claim 1, characterized in that: The nano-zinc oxide has a particle size ≤50nm and a specific surface area ≥50m². 2 / g.

8. The composition with deodorizing and antipruritic effects according to claim 1, characterized in that, The composition also includes, by weight, 0.1-0.5 parts of menthol.

9. The application of a composition having deodorizing and antipruritic effects as described in any one of claims 1-8, characterized in that: The composition is applied to a panty liner for the preparation of feminine panty liners.

10. The application of the composition with deodorizing and antipruritic effects according to claim 9, characterized in that: The base material of the pad is a breathable non-woven fabric with a basis weight of 25 g / m2. The surface of the breathable non-woven fabric is coated with hydroxyethyl cellulose colloid with a viscosity ≥2000 mPa·s.

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