A method for osmotic treatment of tylosin production waste liquid

Abstract

The application discloses a kind of tylosin preparation waste liquid's osmotic treatment method, belong to pharmaceutical wastewater treatment technical field;For the problems that existing process parameter relies on experience, membrane pollution is serious, resource recovery rate is low and cannot dynamically adapt market and environmental change, the application constructs four-stage combined membrane process, with pretreatment pH, ammonium bicarbonate concentration, nanofiltration operating pressure as independent variable generates multiple sets of operation set, establishes the quantification quality evaluation system covering each key parameter, calculates the quality coefficient and processing performance coefficient of each link, automatically selects the top three optimal operation scheme, and supports adaptive weight adjustment, the application realizes water resource reuse, tylosin recovery and sodium sulfate resource, significantly prolongs the service life of membrane element, greatly improves process flexibility and dynamic adaptability, and gives consideration to environmental benefits and economic benefits.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical wastewater treatment technology, and more specifically, to a permeation treatment method for tylosin production waste liquid. Background Technology

[0002] Tylosin, a broad-spectrum macrolide antibiotic, is widely used in livestock and poultry farming for disease prevention and growth promotion due to its strong antibacterial activity and low toxicity. Its industrial production mainly adopts the microbial fermentation method. During the extraction and refining process of tylosin, a large amount of high-concentration organic waste liquid is generated. This type of waste liquid has a complex composition, containing not only residual tylosin, macromolecular proteins, polysaccharides, mycelia and other organic pollutants, but also high concentrations of sulfate. It is characterized by high chemical oxygen demand (COD), poor biodegradability and strong biotoxicity. If directly discharged, it will not only cause serious water pollution and damage aquatic ecosystems, but also lead to antibiotic resistance caused by antibiotic residues. At the same time, it will waste recyclable substances such as tylosin and sulfate, which does not meet the requirements of green production and circular economy development in the pharmaceutical industry.

[0003] Currently, conventional methods for treating tylosin production waste liquid still have the following technical shortcomings in practical applications: In terms of process operation parameters, they mostly rely on the experience of operators to set, and no systematic quantitative optimization mechanism has been established for key influencing factors such as pretreatment pH, forward osmosis draw solution concentration, and nanofiltration operating pressure. As a result, it is impossible to simultaneously take into account water resource reuse efficiency, tylosin recovery rate and sulfate separation effect, and problems such as large loss of tylosin, unstable product water quality, and the need for secondary treatment of concentrate often occur. On the other hand, the existing evaluation system for the process is rigid and lacks dynamic adjustment capabilities. When the market price of tylosin fluctuates, environmental emission standards are raised, or environmental fines are increased, the focus of the process cannot be adjusted quickly, making it difficult to balance the economic and environmental benefits of the treatment process.

[0004] To address this, a permeation treatment method for tylosin production waste liquid has been developed. Summary of the Invention

[0005] In order to overcome the above-mentioned defects of the prior art, embodiments of the present invention provide a permeation treatment method for tylosin production waste liquid.

[0006] To achieve the above objectives, the present invention provides the following technical solution: A method for permeation treatment of tylosin production waste liquid, comprising: Process variable setting: The operating parameters in the permeation process are used as independent variables, and random perturbation is performed within the preset adjustable range of each independent variable to form a set of operations in the permeation process. Pretreatment: The pH of the tylosin production waste liquid is adjusted to the set value in the target operation set, and then filtered through a tubular ultrafiltration membrane to obtain the pretreated waste liquid; Forward osmosis treatment: The pretreated waste liquid is sent into the forward osmosis unit, and the ammonium bicarbonate solution of the set concentration in the target operation set is used as the draw liquid. The forward osmosis membrane is used for separation treatment to obtain forward osmosis permeate and forward osmosis concentrate. Nanofiltration treatment: Using the set driving pressure in the target operation set, the forward osmosis concentrate is sent into the nanofiltration device, and the polyamide nanofiltration membrane is used for separation to obtain nanofiltration permeate and nanofiltration concentrate; Reverse osmosis treatment: The nanofiltration permeate is fed into the reverse osmosis unit and concentrated using a reverse osmosis membrane to obtain reverse osmosis permeate and reverse osmosis concentrate. Sodium sulfate is recovered by crystallizing the reverse osmosis concentrate. Operation Locking: Based on the quality assessment coefficients of the liquids associated with each step after different operation sets are executed, the operation sets are filtered and eliminated using pre-edited screening logic to determine the optimal operation set and push it to the operator.

[0007] Specifically, the independent variables include pretreatment pH, forward osmosis absorbent concentration, and nanofiltration operating pressure; Related liquids include forward osmosis permeate, nanofiltration concentrate, reverse osmosis permeate, and reverse osmosis concentrate.

[0008] Specifically, the quality parameters associated with forward osmosis permeate include the fouling index, tylosin residue, and chemical oxygen demand. Then output the quality assessment coefficient of the positive osmosis permeate according to the logic. By analyzing the pollution index Tylosin residues and chemical oxygen demand The output is obtained after weighted fusion processing based on the quality standards of the forward osmosis permeate; The specific calculation process is as follows: Quality assessment coefficient of forward osmosis permeate ; in , , These are preset weighting coefficients, and their sum is one; , , The preset acceptable contamination index, acceptable tylosin residue, and acceptable chemical oxygen demand are the criteria for the quality standards of the positive osmosis permeate.

[0009] Specifically, the quality parameters associated with nanofiltration concentrate include tylosin concentration, tylosin recovery rate, and sulfate concentration. Then output the quality assessment coefficient of the nanofiltration concentrate according to the logic. By measuring tylosin concentration Tylosin recovery rate sulfate concentration The output is obtained after weighted fusion processing based on the quality standards of the nanofiltration concentrate; The specific calculation process is as follows: Quality assessment coefficient of nanofiltration concentrate ; in , , These are preset weighting coefficients, and their sum is one; , The preset qualified tylosin concentration, qualified tylosin recovery rate, and qualified sulfate concentration are specified in the nanofiltration concentrate quality standards.

[0010] Specifically, The quality parameters associated with reverse osmosis permeate include chemical oxygen demand, tylosin residue, and reverse osmosis desalination rate. Then output the quality assessment coefficient of the reverse osmosis permeate according to the logic. By analyzing chemical oxygen demand Tylosin residues and reverse osmosis desalination rate The output is then weighted and fused based on the quality standards of the reverse osmosis permeate. The specific calculation process is as follows: Quality assessment coefficient of reverse osmosis permeate ; in , , These are preset weighting coefficients, and their sum is one; , , These are the preset acceptable limits for tylosin residue, acceptable chemical oxygen demand, and acceptable lower limit for reverse osmosis desalination rate in the quality standards for reverse osmosis permeate.

[0011] Specifically, the quality parameters associated with reverse osmosis concentrate include sulfate concentration, chemical oxygen demand, and tylosin residue. Then output the quality assessment coefficient of the reverse osmosis concentrate according to the logic. By measuring sulfate concentration Chemical oxygen demand Tylosin residues The output is obtained after weighted fusion processing based on the quality standards of the reverse osmosis concentrate; The specific calculation process is as follows: Quality assessment coefficient of reverse osmosis concentrate ; in , , These are preset weighting coefficients, and their sum is one; , The preset qualified sulfate concentration, qualified chemical oxygen demand, and qualified tylosin residue in the reverse osmosis concentrate.

[0012] Specifically, the process of executing the filtering logic; Based on the quality assessment coefficients of the liquids associated with each step after different operation sets are executed, and combined with the pre-set liquid quality weights of the liquids associated with each step, a weighted fusion process is performed to output the processing performance coefficients of different operation sets.

[0013] Specifically, the logic for determining the optimal set of operations; Based on the magnitude of the performance coefficient, different operation sets are sorted from largest to smallest. The top three operation sets, starting from the left, are selected as the preferred operation sets and pushed to the operators.

[0014] The technical effects and advantages of this invention are as follows: This invention constructs a four-stage combined membrane process, realizing the full resource utilization and harmless treatment of tylosin production waste liquid. Through the pretreatment unit of alkali adjustment stabilization, coagulation sedimentation combined with tubular ultrafiltration, suspended solids, macromolecular organic matter and some residual tylosin in the waste liquid are efficiently removed, blocking the pollution of subsequent precision membrane elements from the source and significantly extending the membrane service life. At the same time, the permeate from forward osmosis and reverse osmosis can be directly reused in production or discharged after meeting the standards. The nanofiltration concentrate is enriched with high-purity tylosin and can be recycled. The reverse osmosis concentrate is crystallized to recover industrial-grade sodium sulfate, which completely solves the problems of serious pollution and large loss of resources in traditional processes, and takes into account both environmental and economic benefits. The closed-loop optimization system established in this invention solves the pain points of traditional process parameters relying on experience and being unable to achieve multi-objective collaborative optimization. It generates multiple sets of operations with pretreatment pH, forward osmosis draw solution concentration, and nanofiltration operating pressure as independent variables. Through quantitative quality assessment logic covering various key parameters, it calculates the quality coefficient of each link and outputs the treatment performance coefficient, automatically selects the top three optimal solutions, and supports adaptive weight adjustment. It can quickly adjust the process focus according to changes in tylosin market price and environmental standards, greatly improving the process flexibility and dynamic adaptability. Attached Figure Description

[0015] Figure 1 This is a flowchart of a method for permeation treatment of waste liquid from tylosin production according to the present invention. Detailed Implementation

[0016] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0017] like Figure 1 As shown, a method for permeation treatment of tylosin production waste liquid is as follows: Process variable setting: The operating parameters in the permeation process are used as independent variables, and random perturbation is performed within the preset adjustable range of each independent variable to form a set of operations in the permeation process. Independent variables include pretreatment pH, forward osmosis draw concentration, and nanofiltration operating pressure; Additional notes: Pretreatment pH refers to the target pH value achieved after adding alkali to the tylosin waste liquid during the pretreatment stage (the corresponding adjustable range of the independent variable is set to 7.5–8.5). The concentration of the forward osmosis absorbent refers to the molar concentration of the ammonium bicarbonate solution used to generate the driving force of osmotic pressure in the forward osmosis process (the corresponding adjustable range of the independent variable is set to 1.5–3.0 mol / L). Nanofiltration operating pressure refers to the driving pressure applied to the inlet side of the nanofiltration membrane during separation (the corresponding adjustable range of independent variables is set to 1.5–3.0 MPa).

[0018] Each parameter is randomly selected from its own limit range; Each set of operations equals one set of experimental formulas; Each set = (one pH + one draw solution concentration + one nanofiltration pressure) is one operating procedure; For example: Group 1: pH=7.8, draw solution 2.0 mol / L, nanofiltration pressure (2.2 MPa); Group 2: pH=8.3, draw solution 2.7mol / L, nanofiltration pressure (1.8MPa); Collecting many combinations together, the total number of combinations equals the set of operations.

[0019] Pretreatment: Adjust the pH of the tylosin production waste liquid to the set value in the target operation set; add coagulant and coagulant aid, stir and react, and then precipitate. The supernatant is filtered through a tubular ultrafiltration membrane to remove suspended solids, macromolecular organic matter and some residual tylosin to obtain pretreated waste liquid. The wastewater is stabilized by adjusting the alkali, and then coagulation sedimentation and tubular ultrafiltration membrane are used to efficiently remove suspended solids and large particulate organic matter, preventing clogging of downstream precision membrane elements, while also recovering some residual tylosin.

[0020] Forward osmosis treatment: The pretreated waste liquid is sent into the forward osmosis unit, and the ammonium bicarbonate solution of the set concentration in the target operation set is used as the draw liquid. The modified polyamide forward osmosis membrane is used for separation treatment to obtain forward osmosis permeate and forward osmosis concentrate. The permeate from forward osmosis is recycled clean water that can be directly reused in the production process; the concentrate from forward osmosis is enriched with residual tylosin and high concentrations of sulfate.

[0021] Nanofiltration treatment: Using the set driving pressure in the target operation set, the forward osmosis concentrate is sent into the nanofiltration device, and the polyamide nanofiltration membrane is used for separation to obtain nanofiltration permeate and nanofiltration concentrate; The nanofiltration concentrate is enriched with tylosin, which can be recycled for use in the production process; the nanofiltration permeate mainly contains sulfate.

[0022] Reverse osmosis treatment: The nanofiltration permeate is fed into the reverse osmosis unit and concentrated using a disc tube reverse osmosis membrane to obtain reverse osmosis permeate and reverse osmosis concentrate. Sodium sulfate is recovered by crystallizing the reverse osmosis concentrate. The reverse osmosis permeate is high-purity water, which can be directly discharged or reused in production. The reverse osmosis concentrate contains a high concentration of sulfates.

[0023] Liquid evaluation: After completing the pretreatment, forward osmosis, nanofiltration and reverse osmosis steps using the locked set of target operations, the quality parameters of the liquids associated with each step are evaluated in a targeted manner, and the quality evaluation coefficients of the liquids associated with each step are output. Related liquids include forward osmosis permeate, nanofiltration concentrate, reverse osmosis permeate, and reverse osmosis concentrate; Specifically: The quality parameters associated with forward osmosis permeate include the fouling index, tylosin residue, and chemical oxygen demand. Then output the quality assessment coefficient of the positive osmosis permeate according to the logic. Collect the set volume of forward osmosis permeate sample in a clean container; install the contamination index meter, insert a 0.45μm filter membrane, remove air, adjust the pressure to the preset value, and start timing; record the time required to initially collect the set volume of water sample, and record it as the initial duration; Continue operating at the preset pressure and record the time required to collect the set milliliter water sample again, which is recorded as the filtration collection time. Pollution index ;in This is the initial duration. For filter collection duration; Additional note: If the filter membrane is completely clogged after 15 minutes of operation and the set volume of water cannot be collected, the pollution index will be recorded as 100% as the maximum pollution tendency.

[0024] Take a set amount of positive osmosis permeate in milliliters, enrich and purify it using an activated HLB solid-phase extraction column, elute with methanol and bring the volume to the set amount in milliliters; Chromatographic conditions: C18 reversed-phase column (250 mm × 4.6 mm, 5 μm), mobile phase: acetonitrile: 0.01 mol / L sodium dihydrogen phosphate solution (pH 2.5) = 35:65, detection wavelength 280 nm, flow rate 1.0 mL / min, injection volume 20 μL; Prepare a stock solution of tylosin (e.g., 100 mg / L), and then dilute it sequentially to obtain a standard series of 1.0, 5.0, 10.0, 20.0, and 50.0 mg / L. Measure the peak area under pre-edited chromatographic conditions and plot a standard curve. Tylosin residue ;in The peak area of ​​the sample. Let b be the slope and intercept of the standard curve. To adjust the volume of the eluent, This represents the volume of the water sample.

[0025] When used for recycling process water, tylosin residues must not be too high to avoid contaminating the production system and causing potency confusion.

[0026] The chemical oxygen demand of the forward osmosis permeate was measured using the potassium dichromate digestion method. Accurately pipette the set amount of positive osmosis permeate into a 250 mL ground glass conical flask; Additional notes: To eliminate chloride ion interference: Add 0.4g of mercuric sulfate and shake well (this step can be omitted if the chloride ion concentration in the water sample is <30mg / L).

[0027] Add 10.00 mL of 0.02500 mol / L potassium dichromate standard solution and a few glass beads, and shake well; Connect the condenser tube and slowly add 0 mL of sulfuric acid-silver sulfate solution from the top of the condenser tube. Gently shake the conical flask to mix the solution evenly. After heating the solution to boiling, maintain reflux for 2 hours (starting from the time the solution begins to boil). Stop heating and cool to room temperature. Rinse the inner wall of the condenser tube with 90 mL of water from the top of the condenser tube and remove the conical flask. After the solution is cooled to room temperature, add 3 drops of ferroin indicator and titrate with 0.01 mol / L ferrous ammonium sulfate standard solution until the solution changes from yellow to blue-green to reddish-brown, which is the endpoint. Record the volume of ferrous ammonium sulfate standard solution consumed. At the same time, perform a blank experiment by taking 20.00 mL of ultrapure water instead of the water sample, and follow the above steps to record the volume of ferrous ammonium sulfate standard solution consumed in the blank experiment. Accurately pipette 10.00 mL of 0.02500 mol / L potassium dichromate standard solution into a 250 mL Erlenmeyer flask, add 30 mL of water and 30 mL of concentrated sulfuric acid, cool, add 3 drops of ferroin indicator, titrate with ferrous ammonium sulfate standard solution to the endpoint, and record the volume consumed; Concentration of ferrous ammonium sulfate standard solution ; To consume volume; Chemical oxygen demand ; in The volume of ferrous ammonium sulfate standard solution consumed in the blank experiment; V represents the volume of ferrous ammonium sulfate standard solution consumed in the titration of the water sample; 8 represents the molar mass of oxygen (1 / 2O); and V represents the volume of the water sample.

[0028] For clean water reused in production, the lower the chemical oxygen demand (COD) should generally be, the better, to ensure that no organic load is introduced into the system.

[0029] The quality assessment coefficient of the forward osmosis permeate is output by weighting and integrating the contamination index, tylosin residue, and chemical oxygen demand with the quality standards of the forward osmosis permeate. The specific calculation process is as follows: Quality assessment coefficient of forward osmosis permeate ; in , , These are preset weighting coefficients, and their sum is one; , , The preset acceptable contamination index, acceptable tylosin residue, and acceptable chemical oxygen demand are the criteria for the quality standards of the positive osmosis permeate.

[0030] The quality parameters associated with nanofiltration concentrate include tylosin concentration, tylosin recovery rate, and sulfate concentration. Then output the quality assessment coefficient of the nanofiltration concentrate according to the logic. Take a uniform sample of 100 mL from the nanofiltration concentrate outlet and dilute it to the linear range of the standard curve using a mobile phase (acetonitrile: 0.01 mol / L sodium dihydrogen phosphate solution = 35:65). (The estimated concentration of tylosin in the concentrate is usually in the g / L range, and it can be diluted 100-1000 times.) Filter the sample through a 0.22 μm nylon filter membrane. Based on the same chromatographic conditions as the forward osmosis permeate detection, a series of tylosin standards (e.g., 10, 50, 100, 200, 500 mg / L) were prepared, peak areas were determined, and regression equations were established. Tylosin concentration ; in The peak area of ​​the sample. 'a' represents the slope and intercept of the curve. D represents the dilution factor.

[0031] The higher the concentration, the better, as it increases the economic value of recycling.

[0032] Take samples of nanofiltration feed solution (i.e. forward osmosis concentrate) and nanofiltration concentrate, respectively, and determine the tylosin concentration in the feed solution and the tylosin concentration in the concentrate by HPLC. The feed flow rate and concentrate flow rate per unit time were measured using a graduated cylinder and a stopwatch. Tylosin recovery rate ; in and These represent the tylosin concentrations in the feed solution and the concentrated solution, respectively. and These represent the feed flow rate and the concentrate flow rate, respectively.

[0033] A lower recovery rate means that a large amount of drug is lost with the permeate, and the nanofiltration membrane becomes selectively ineffective.

[0034] Take the nanofiltration concentrate sample, filter it through a 0.22 μm filter membrane, and dilute it with ultrapure water to the set factor; inject it into an ion chromatograph, an anion analysis column, and use a sodium carbonate / sodium bicarbonate system as the eluent to suppress conductivity detection; Establish a standard curve using sulfate standard solutions (e.g., 10, 20, 50, 100 mg / L); sulfate concentration The symbol has the same meaning as above. The lower the sulfate concentration, the higher the cleanliness of the tylosin recovery solution.

[0035] The quality assessment coefficient of nanofiltration concentrate is output by weighted fusion processing of tylosin concentration, tylosin recovery rate, sulfate concentration, and the quality standard of nanofiltration concentrate. The specific calculation process is as follows: Quality assessment coefficient of nanofiltration concentrate ; in , , These are preset weighting coefficients, and their sum is one; , The preset qualified tylosin concentration, qualified tylosin recovery rate, and qualified sulfate concentration are specified in the nanofiltration concentrate quality standards.

[0036] The quality parameters associated with reverse osmosis permeate include chemical oxygen demand, tylosin residue, and reverse osmosis desalination rate. Then output the quality assessment coefficient of the reverse osmosis permeate according to the logic. Similarly, based on the logic of obtaining the chemical oxygen demand (COD) and tylosin residue of the forward osmosis permeate, the COD and tylosin residue of the reverse osmosis permeate can be calculated.

[0037] Collect nanofiltration permeate and reverse osmosis permeate samples simultaneously in a clean beaker, and measure their conductivity separately using a conductivity meter. The sample temperature should be controlled within the set range during measurement.

[0038] The reverse osmosis desalination rate ;in and These represent the conductivity of the nanofiltration permeate and the reverse osmosis permeate, respectively.

[0039] The quality assessment coefficient of the reverse osmosis permeate is output after weighted fusion processing of chemical oxygen demand, tylosin residue, and reverse osmosis desalination rate, combined with the quality standards of the reverse osmosis permeate. The specific calculation process is as follows: Quality assessment coefficient of reverse osmosis permeate ; in , , These are preset weighting coefficients, and their sum is one; and These represent the tylosin residue and chemical oxygen demand of the reverse osmosis permeate, respectively. , , These are the preset acceptable limits for tylosin residue, acceptable chemical oxygen demand, and acceptable lower limit for reverse osmosis desalination rate in the quality standards for reverse osmosis permeate.

[0040] Quality parameters associated with reverse osmosis concentrate include sulfate concentration, chemical oxygen demand, and tylosin residue. Then output the quality assessment coefficient of the reverse osmosis concentrate according to the logic. Similarly, based on the logic of obtaining the chemical oxygen demand (COD) and tylosin residue of the forward osmosis permeate, the COD and tylosin residue of the reverse osmosis concentrate are calculated. Similarly, the sulfate concentration of the nanofiltration concentrate is obtained by calculating the sulfate concentration of the reverse osmosis concentrate. The quality assessment coefficient of reverse osmosis concentrate is output by weighting and integrating factors such as sulfate concentration, chemical oxygen demand, and tylosin residue with the quality standards of reverse osmosis concentrate. The specific calculation process is as follows: Quality assessment coefficient of reverse osmosis concentrate ; in , , These are preset weighting coefficients, and their sum is one; , as well as These represent the sulfate concentration, chemical oxygen demand, and tylosin residue of the reverse osmosis concentrate, respectively. , The preset qualified sulfate concentration, qualified chemical oxygen demand, and qualified tylosin residue in the reverse osmosis concentrate.

[0041] Operation Locking: Based on the quality assessment coefficients of the liquids associated with each step after different operation sets are executed, the operation sets are screened and eliminated using pre-edited screening logic to determine the preferred operation set and push it to the operator; Specifically: Based on the quality evaluation coefficients of the liquids associated with each step after different operation sets are executed, and combined with the pre-set liquid quality weights of the liquids associated with each step, a weighted fusion process is performed to output the processing performance coefficients of different operation sets. The specific calculation process is as follows: Processing performance coefficient ; , , , These are preset weighting coefficients, and their sum is one.

[0042] Based on the magnitude of the performance coefficient, different operation sets are sorted from largest to smallest. The top three operation sets, starting from the left, are selected as the preferred operation sets and pushed to the operators.

[0043] Additional notes: Operators can adaptively adjust the liquid mass weight in the performance coefficient, i.e. , , , When market prices fluctuate (such as an increase in the price of tylosin or an increase in environmental fines), a new optimal set of operations can be quickly obtained simply by adjusting the weights.

[0044] The above formulas are all dimensionless calculations. Dimensionless calculations can be performed using various methods such as standardization, which will not be elaborated here. The formulas are derived from software simulations based on a large amount of collected data, and the preset parameters in the formulas can be set by those skilled in the art according to the actual situation.

[0045] The above embodiments can be implemented, in whole or in part, by software, hardware, firmware, or any other combination thereof. When implemented using software, the above embodiments can be implemented, in whole or in part, as a computer program product. The computer program product includes one or more computer instructions or computer programs. When the computer instructions or computer programs are loaded or executed on a computer, all or part of the processes or functions described in the embodiments of this application are generated. The computer can be a general-purpose computer, a special-purpose computer, a computer network, or other programmable device. The computer instructions can be stored in a computer-readable storage medium or transmitted from one computer-readable storage medium to another. For example, the computer instructions can be transmitted from one website, computer, server, or data center to another website, computer, server, or data center via wired or wireless (e.g., infrared, wireless, microwave, etc.) means. The computer-readable storage medium can be any available medium that a computer can access or a data storage device such as a server or data center that includes one or more sets of available media. The available medium can be a magnetic medium (e.g., floppy disk, ATA hard disk, magnetic tape), an optical medium (e.g., DVD), or a semiconductor medium. The semiconductor medium can be a solid-state ATA hard disk.

[0046] It should be understood that in the various embodiments of this application, the sequence number of each process does not imply the order of execution. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of this application.

[0047] Those skilled in the art will recognize that the units and algorithm steps of the various examples described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are implemented in hardware or software depends on the specific application and design constraints of the technical solution. Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of this application.

[0048] In the several embodiments provided in this application, it should be understood that the disclosed systems, apparatuses, and methods can be implemented in other ways. For example, the apparatus embodiments described above are merely illustrative; for instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be through some interfaces; the indirect coupling or communication connection between apparatuses or units may be electrical, mechanical, or other forms.

[0049] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment, depending on actual needs.

[0050] In addition, the functional units in the various embodiments of this application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit.

[0051] If the aforementioned functions are implemented as software functional units and sold or used as independent products, they can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or a portion of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of this application. The aforementioned storage medium includes various media capable of storing program code, such as USB flash drives, portable ATA hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.

[0052] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A method for permeation treatment of tylosin production waste liquid, characterized in that, include: Process variable setting: The operating parameters in the permeation treatment process are used as independent variables, and random perturbation is performed within the preset adjustable range of each independent variable to form a set of operations in the permeation treatment process; Pretreatment: The pH of the tylosin production waste liquid is adjusted to the set value in the target operation set, and then filtered through a tubular ultrafiltration membrane to obtain the pretreated waste liquid; Forward osmosis treatment: The pretreated waste liquid is sent into the forward osmosis unit, and the ammonium bicarbonate solution of the set concentration in the target operation set is used as the draw liquid. The forward osmosis membrane is used for separation treatment to obtain forward osmosis permeate and forward osmosis concentrate. Nanofiltration treatment: Using the set driving pressure in the target operation set, the forward osmosis concentrate is sent into the nanofiltration device, and the polyamide nanofiltration membrane is used for separation to obtain nanofiltration permeate and nanofiltration concentrate; Reverse osmosis treatment: The nanofiltration permeate is fed into the reverse osmosis unit and concentrated using a reverse osmosis membrane to obtain reverse osmosis permeate and reverse osmosis concentrate. Sodium sulfate is recovered by crystallizing the reverse osmosis concentrate. Operation Locking: Based on the quality assessment coefficients of the liquids associated with each step after different operation sets are executed, the operation sets are filtered and eliminated using pre-edited screening logic to determine the optimal operation set and push it to the operator.

2. The permeation treatment method for tylosin production waste liquid according to claim 1, characterized in that: Independent variables include pretreatment pH, forward osmosis draw concentration, and nanofiltration operating pressure; Related liquids include forward osmosis permeate, nanofiltration concentrate, reverse osmosis permeate, and reverse osmosis concentrate.

3. The permeation treatment method for tylosin production waste liquid according to claim 2, characterized in that: The quality parameters associated with forward osmosis permeate include the fouling index, tylosin residue, and chemical oxygen demand. Then output the quality assessment coefficient of the positive osmosis permeate according to the logic. By analyzing the pollution index Tylosin residues and chemical oxygen demand The output is obtained after weighted fusion processing based on the quality standards of the forward osmosis permeate; The specific calculation process is as follows: Quality assessment coefficient of forward osmosis permeate ; in , , These are preset weighting coefficients, and their sum is one; , , The preset acceptable contamination index, acceptable tylosin residue, and acceptable chemical oxygen demand are the criteria for the quality standards of the positive osmosis permeate.

4. The permeation treatment method for tylosin production waste liquid according to claim 3, characterized in that: The quality parameters associated with nanofiltration concentrate include tylosin concentration, tylosin recovery rate, and sulfate concentration. Then output the quality assessment coefficient of the nanofiltration concentrate according to the logic. By measuring tylosin concentration Tylosin recovery rate sulfate concentration The output is obtained after weighted fusion processing based on the quality standards of the nanofiltration concentrate; The specific calculation process is as follows: Quality assessment coefficient of nanofiltration concentrate ; in , , These are preset weighting coefficients, and their sum is one; , The preset qualified tylosin concentration, qualified tylosin recovery rate, and qualified sulfate concentration are specified in the nanofiltration concentrate quality standards.

5. The permeation treatment method for tylosin production waste liquid according to claim 4, characterized in that: The quality parameters associated with reverse osmosis permeate include chemical oxygen demand, tylosin residue, and reverse osmosis desalination rate. Then output the quality assessment coefficient of the reverse osmosis permeate according to the logic. By analyzing chemical oxygen demand Tylosin residues and reverse osmosis desalination rate The output is then weighted and fused based on the quality standards of the reverse osmosis permeate. The specific calculation process is as follows: Quality assessment coefficient of reverse osmosis permeate ; in , , These are preset weighting coefficients, and their sum is one; , , These are the preset acceptable limits for tylosin residue, acceptable chemical oxygen demand, and acceptable lower limit for reverse osmosis desalination rate in the quality standards for reverse osmosis permeate.

6. The permeation treatment method for tylosin production waste liquid according to claim 5, characterized in that: Quality parameters associated with reverse osmosis concentrate include sulfate concentration, chemical oxygen demand, and tylosin residue. Then output the quality assessment coefficient of the reverse osmosis concentrate according to the logic. By measuring sulfate concentration Chemical oxygen demand Tylosin residues The output is obtained after weighted fusion processing based on the quality standards of the reverse osmosis concentrate; The specific calculation process is as follows: Quality assessment coefficient of reverse osmosis concentrate ; in , , These are preset weighting coefficients, and their sum is one; , The preset qualified sulfate concentration, qualified chemical oxygen demand, and qualified tylosin residue in the reverse osmosis concentrate.

7. The permeation treatment method for tylosin production waste liquid according to claim 6, characterized in that: The filtering logic execution process; Based on the quality assessment coefficients of the liquids associated with each step after different operation sets are executed, and combined with the pre-set liquid quality weights of the liquids associated with each step, a weighted fusion process is performed to output the processing performance coefficients of different operation sets.

8. The permeation treatment method for tylosin production waste liquid according to claim 7, characterized in that: The logic for determining the optimal set of operations; Based on the magnitude of the performance coefficient, different operation sets are sorted from largest to smallest. The top three operation sets, starting from the left, are selected as the preferred operation sets and pushed to the operators.

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