A 3D printing method for post-donation human care of human organs

Abstract

The application discloses a 3D printing method for human organ after donation, which comprises the following steps: first, acquiring human organ image data, and then performing 3D modeling on the human organ based on the human organ image data to generate a human organ 3D model containing a ring-shaped suture area, a suture auxiliary hole and a suture guide groove; second, performing quality evaluation on the human organ 3D model; if the quality evaluation is qualified, performing 3D printing on the human organ 3D model; and finally, placing the printed human organ 3D printing entity based on the ring-shaped suture area, the suture auxiliary hole and the suture guide groove, which solves the technical problems of cavity formation, insufficient structural support and decline of the integrity of the body shape caused by the missing of the organs in the donor's body after organ donation, realizes the replacement of the appearance of the organs in the donor's body and the recovery of the cavity shape, and embodies the human dignity and memorial significance of organ donation.

Description

Technical Field

[0001] This invention relates to the field of assistive devices for medical humanistic care, and in particular to a 3D printing method for human organ donation for post-donation humanistic care. Background Technology

[0002] In the existing organ donation process, vital organs such as the heart, liver, lungs, and kidneys are removed from the donor during the donation surgery and used for transplantation. After donation, a significant cavity forms in the corresponding organ location within the donor's body cavity. Currently, clinical practice typically involves directly suturing to close the body cavity or packing it with ordinary dressings. While these methods can accomplish basic body handling, they still have the following shortcomings: 1. The donor's internal organs are missing, and the overall anatomical integrity is insufficient, which is not conducive to the reconstruction of the remains; 2. It is difficult to reflect the dignity and commemorative significance of organ donation during the farewell ceremony or subsequent handling of the deceased. Summary of the Invention

[0003] This invention provides a 3D printing method for human organs used in post-donation humanistic care, which solves the technical problems in the prior art of organ donation, such as the formation of body cavity cavities, insufficient structural support, and decline in the integrity of the remains due to the absence of organs in the donor's body. It realizes the replacement of the donor's internal organs in terms of shape and the restoration of the body cavity morphology, reflecting the humanistic dignity and commemorative significance of organ donation.

[0004] This invention provides a 3D printing method for human organs used in post-donation humanitarian care, comprising: Acquire human organ imaging data; Based on the aforementioned human organ image data, 3D modeling of human organs is performed to generate a 3D model of human organs including a circumferential suture area, suture auxiliary holes, and suture guide grooves. The quality of the 3D models of the human organs was assessed. If the quality assessment is satisfactory, the 3D model of the human organ will be 3D printed.

[0005] Specifically, the step of performing 3D modeling of human organs based on the human organ image data to generate a 3D model of the human organ including a circumferential suture area, suture auxiliary holes, and suture guide grooves includes: Based on the human organ image data, feature extraction is performed to obtain a modeling feature file; Based on the modeling feature file, 3D modeling of human organs is performed to generate preliminary 3D models of human organs. At the edge of the suture area corresponding to the preliminary 3D model of the human organ, a ring-shaped suture area is set, and the wall thickness of the ring-shaped suture area is thickened compared to the suture area. Within the circumferential suture area, multiple through holes are arranged at equal intervals along the edge line to form suture auxiliary holes; Grooves are set along the model surface between adjacent suture auxiliary holes to form suture guide grooves.

[0006] Specifically, the quality assessment of the 3D model of the human organ includes: If the wall thickness of the circumferential suture area is less than the set first wall thickness, or the diameter of the suture auxiliary hole is less than the set diameter, or the wall thickness of the suture auxiliary hole is less than the set second wall thickness, or the maximum inscribed circle diameter of the cross-section of the suture guide groove is less than the set diameter, then the quality is deemed unqualified.

[0007] Specifically, it also includes: Using the maximum inscribed sphere algorithm, a maximum sphere is fitted inside the structure at the edge of the suture auxiliary hole, and the diameter of this sphere is used as the local nominal wall thickness of the region.

[0008] Specifically, it also includes: Along the axial direction of the suture guide groove, cross sections are cut at fixed intervals, and the maximum inscribed circle diameter of the cross section is calculated.

[0009] Specifically, the quality assessment of the 3D model of the human organ includes: Traverse all edges of the 3D model of the human organ and count the number of times each edge is shared by a triangular facet. If an edge is shared by multiple triangular faces or multiple triangular faces are connected only by a single isolated vertex, it is considered to be of substandard quality.

[0010] Specifically, the quality assessment of the 3D model of the human organ includes: Randomly select a starting face from the 3D model of the human organ, execute the seed filling algorithm, and traverse all faces connected by common edges; If any unmarked vertices or faces exist after the traversal is complete, the traversal is considered unqualified.

[0011] Specifically, the quality assessment of the 3D model of the human organ includes: Actual shrinkage rate using the formula Calculate the actual shrinkage rate of the 3D model of the human organ along the three principal axes of length, width, and height. ;in, The maximum outer contour dimensions of the 3D model of the human organ along the three principal axes of length, width, and height. The maximum outer contour dimension of the surface point cloud in the modeling feature file along the three principal axes of length, width, and height; If the actual shrinkage rate of the 3D model of the human organ in the three main axes of length, width, and height is... If all values ​​are less than the set shrinkage rate threshold, the product is considered to be of acceptable quality. or, Calculate the Euclidean distance between the surface point cloud of the modeling feature file and the surface of the 3D model of the human organ; If the Euclidean distance is less than or equal to within the set tolerance range, the quality is deemed acceptable.

[0012] Specifically, after 3D printing the 3D model of the human organ, the process further includes: The 3D printed human organ entity is placed based on the circumferential suture area, suture auxiliary hole, and suture guide groove.

[0013] Specifically, the placement of the 3D-printed human organ entity based on the annular suture area, suture auxiliary hole, and suture guide groove includes: Within the circumferential suture area, sutures are passed through the suture auxiliary holes and fixed to the tissue surrounding the target organ. The suture path is then regulated by the suture guide groove to achieve the placement of the 3D printed human organ.

[0014] One or more technical solutions provided in this invention have at least the following technical effects or advantages: First, human organ imaging data is acquired. Then, 3D modeling of the human organ is performed based on the imaging data, generating a 3D model of the human organ including a circular suture area, suture auxiliary holes, and suture guide grooves. Next, the quality of the 3D model of the human organ is evaluated. If the quality evaluation is qualified, the 3D model of the human organ is 3D printed. Finally, the printed 3D human organ entity is placed based on the circular suture area, suture auxiliary holes, and suture guide grooves. This solves the technical problems in the existing technology of organ donation, such as the formation of body cavity cavities, insufficient structural support, and decline in the integrity of the remains due to the loss of the donor's internal organs. It realizes the replacement of the donor's internal organ shape and the restoration of the body cavity shape, reflecting the humanistic dignity and commemorative significance of organ donation. Attached Figure Description

[0015] Figure 1 A flowchart of a method for 3D printing human organs for post-donation humanistic care provided in an embodiment of the present invention; Figure 2 A schematic diagram of the structure of a 3D model of a human organ obtained by modeling the 3D printing method for human organs used in post-donation humanistic care provided by the embodiments of the present invention. Figure 3This is a schematic diagram illustrating the placement effect of the 3D printed human organ obtained from the 3D printing method for post-donation humanistic care provided in an embodiment of the present invention. Detailed Implementation

[0016] To better understand the above technical solutions, the following will provide a detailed explanation of the technical solutions in conjunction with the accompanying drawings and specific implementation methods.

[0017] like Figure 1 As shown in the embodiment of the present invention, a 3D printing method for human organ donation and post-donation humanistic care includes: Step S110: Acquire human organ imaging data; This step involves obtaining imaging data of human organs, including: Human organ imaging data in DICOM format is obtained and stored using CT or ultrasound scanning.

[0018] Step S120: Based on human organ image data, perform 3D modeling of human organs to generate a 3D model of human organs including a circumferential suture area, suture auxiliary holes, and suture guide groove; This step is explained in detail: based on human organ imaging data, 3D modeling of the human organ is performed, generating a 3D model of the human organ including a circular suture area, suture auxiliary holes, and suture guide grooves, including: Feature extraction is performed based on human organ imaging data to obtain modeling feature files; Based on the modeling feature file, 3D modeling of human organs is performed to generate preliminary 3D models of human organs. Specifically, based on human organ imaging data, corresponding two-dimensional slice image sequences are generated in the axial, sagittal, and coronal directions. Based on the generated two-dimensional slice image sequences, the target organ is segmented to remove non-target tissue regions, generating complete organ contour data and obtaining an initial 3D organ model.

[0019] At the edge of the suture area corresponding to the preliminary 3D model of the human organ, a ring-shaped suture zone is defined, and the wall thickness of the ring-shaped suture zone is thickened compared to the suture area. Specifically, at the edge position of the original anatomical ligament, vascular remnant or mesentery attachment point of the organ model, a ring-shaped suture zone with a width of 5mm-8mm is defined, and the wall thickness of the ring-shaped suture zone is increased by 0.5mm-1.0mm compared to the suture area to form a reinforced "suture band" to prevent the suture line from cutting through the shell when under stress.

[0020] Within the annular suture zone, multiple through holes are arranged at equal intervals along the edge line to form suture auxiliary holes. Specifically, through Boolean difference operations, the spatial volume overlapping with the cylindrical array is removed from the organ model body, thereby forming a through-hole structure in the annular suture zone, with the hole spacing set to 5mm-10mm. The edges of the hole walls are chamfered to smooth them out and prevent sharp edges from scratching the PDS suture lines.

[0021] Between adjacent suture auxiliary holes, grooves (0.5mm-0.8mm deep and wide) are set along the model surface to form suture guide grooves. The function of these grooves is to "bury" the sutures inside the model surface, so that the suture knots will not protrude significantly from the organ surface after suturing. At the same time, the friction generated by the groove walls limits the sutures and prevents them from sliding or shifting during the handling or restoration of the remains.

[0022] Step S130: Perform quality assessment on the 3D model of human organs; This step is explained in detail, and a quality assessment is performed on the 3D model of human organs, including: If the wall thickness of the circumferential suture area is less than the set first wall thickness, or the diameter of the suture auxiliary hole is less than the set diameter, or the wall thickness of the suture auxiliary hole is less than the set second wall thickness, or the maximum inscribed circle diameter of the suture guide groove is less than the set diameter, then the quality is deemed unqualified. Specifically, if the diameter of the suture auxiliary hole is too small, i.e. the hole is closed, or the hole wall thickness is less than the set second wall thickness (e.g., <1.0mm), then it is deemed a functional deformity or incompleteness, and the 3D model of the human organ needs to be re-created. If the wall thickness of the suture auxiliary hole is less than 3-5 times the printing accuracy (e.g., if the SLA printing accuracy is 0.1mm, then the wall thickness is less than 0.3mm-0.5mm), due to insufficient interlayer adhesion strength, the structure is very easy to break during post-processing. In this case, it is deemed "too thin," and the auxiliary structure cannot withstand the suture tension, which is a lack of structural integrity, and the 3D model of the human organ needs to be re-created. If the maximum inscribed circle diameter of the suture guide groove's cross-section is less than 1.2 times the preset suture diameter (for example, for a 0.4mm suture, the inscribed circle must be >0.48mm), then it is determined that there is obstruction or support residue at that location, and the 3D model of the human organ needs to be re-created. Using the maximum inscribed sphere algorithm, a maximum sphere is fitted inside the structure at the edge of the suture auxiliary hole, and the diameter of this sphere is used as the local nominal wall thickness of that area. Along the axial direction of the suture guide groove, cross-sections are cut at fixed steps (e.g., 0.1mm), and the maximum inscribed circle diameter of the cross-section is calculated.

[0023] or, Traverse all edges of the 3D model of human organs and count the number of times each edge is shared by a triangular facet. If an edge is set to be shared by one triangular patch, or multiple triangular patches are connected only through an isolated vertex, it is determined as a topological defect with unqualified quality, and 3D modeling of the human organ needs to be performed again.

[0024] Or, Randomly select a starting patch from the 3D model of the human organ, execute the seed filling algorithm, and traverse all patches connected through shared edges; After the traversal, if there are unmarked vertices or patches, it is determined that the quality is unqualified, and 3D modeling of the human organ needs to be performed again.

[0025] Or, The actual shrinkage rate is calculated by the formula to calculate the actual shrinkage rates of the 3D human organ model in the three principal axis directions of length, width and height respectively ; wherein, is the maximum outer contour dimension of the 3D human organ model in the three principal axis directions of length, width and height, is the maximum outer contour dimension of the surface point cloud of the modeling feature file in the three principal axis directions of length, width and height; If the actual shrinkage rates of the 3D human organ model in the three principal axis directions of length, width and height are all less than the set shrinkage rate threshold, it is determined that the quality is qualified; otherwise, it is determined that there is physical deformation, and 3D modeling of the human organ needs to be performed again. Specifically, the original model is pre-enlarged, with an enlargement coefficient k=1 / (1- ), so as to offset the shrinkage loss during the printing process.

[0026] Or, Calculate the Euclidean distance between the surface point cloud of the modeling feature file and the surface of the 3D human organ model; If the Euclidean distance is within the set tolerance range δ (for example, ±2.0mm), it is determined that the quality is qualified.

[0027] If the Euclidean distance exceeds the set tolerance range δ (positive deviation) or there is a depression (negative deviation), it is determined as "structural deformation" with unqualified quality, and 3D modeling of the human organ needs to be performed again. If the root mean square error (RMSE) of the overall shape exceeds the preset value, it is determined that the overall model is deformed with unqualified quality, and 3D modeling of the human organ needs to be performed again.

[0028] Step S140: If the quality assessment is qualified, perform 3D printing on the 3D human organ model.

[0029] This step is specifically described as follows. Performing 3D printing on the 3D human organ model includes: The model is printed using 3D printing equipment, employing methods such as stereolithography (SLA) or digital light processing (DLP). In some embodiments, the organ model body can be molded using multi-material or multi-color photocurable resin. The printing precision is set as needed, ranging from 30 to 300 micrometers. The model is then configured as a hollow or low-density filled structure. Specifically, using the outer surface of the organ model as a reference, it is offset inwards at equal intervals, with the shell wall thickness set to 1.5 mm to 3.0 mm, generating a hollow structure with a closed cavity. A low-density lattice is then filled within the hollow structure. A geometric topology type (such as honeycomb, gyroscope-like, or simple intersecting mesh) is selected, with an infill rate of 5%-15%. This structure simulates a certain degree of elasticity in real organs, aiding in stress distribution during suturing. For SLA / DLP printing processes, 1-2 discharge holes with a diameter of 2mm-3mm are set on the non-critical display surfaces of the hollow structure (such as the back or bottom of the organ) to discharge the uncured resin liquid inside after printing, preventing the model from cracking due to internal pressure or reaction of residual resin.

[0030] The method of the present invention is described in detail below. After 3D printing the 3D model of a human organ, the method further includes: The 3D printed human organ is placed using a circumferential suture area, suture auxiliary holes, and suture guide grooves.

[0031] This step is explained in detail, involving the placement of the 3D-printed human organ entity based on the circumferential suture area, suture auxiliary holes, and suture guide groove, including: Within the circumferential suture area, PDS sutures are used to pass through the suture auxiliary holes and fix to the tissue surrounding the target organ. The suture path is then regulated by the suture guide groove to achieve the placement of the 3D printed human organ.

[0032] The following describes in further detail the printing method for alternative 3D-printed organ placement structures for humanistic care in organ donation provided by embodiments of the present invention, which specifically includes the following steps: S1: Acquire human organ imaging data; the imaging data includes computed tomography (CT) scan data or ultrasound scan data, and is stored in DICOM format. The imaging data may also be derived from a pre-established standardized human organ database (divided into 0-2 years, 3-5 years, 6-12 years and over 18 years).

[0033] S2: Perform 3D model reconstruction and fusion; S3: Perform structural optimization design on the 3D model, and the resulting 3D model of human organs is as follows: Figure 2 As shown; S4: Perform quality assessment on the 3D model; S5: 3D printing of 3D models; S6: Donor cavity status assessment, specifically including: determining the type of missing organ and its corresponding anatomical location, assessing the size and shape of the cavity space, and judging the integrity of surrounding tissues and suture conditions.

[0034] S7: Based on the evaluation results of S6, select a replacement organ model that matches the donor's body size and missing organ; specifically, select a replacement organ model based on the donor's age and the type of donated organ, including: organ type matching (heart, liver, lung or kidney), size matching (different standardized size grades, divided into 0-2 years, 3-5 years, 6-12 years and over 18 years); in some implementations, an individualized model based on donor image data can be used.

[0035] S8: Pre-installation processing of the model, specifically including: cleaning the model and checking the structural integrity of the model.

[0036] S9: Place the human organ model in the corresponding anatomical location within the donor's body and perform preliminary positioning, specifically including: placing it according to the original anatomical orientation of the organ, adjusting the model's direction and fit, so that the model forms a natural contact relationship with the surrounding tissues.

[0037] S10: Use auxiliary structures set on the model surface to fix and guide the stitching of the model; S11: After the model is fixed, the donor body cavity is closed and the structure is restored, which includes: repositioning the surrounding tissues, suturing the body wall layer by layer, and restoring the integrity of the body surface structure.

[0038] S12: Evaluate the overall restoration effect after placement, specifically including: integrity of the body surface morphology, symmetry of local structures, model stability, and absence of abnormal protrusions or collapses, etc., and the placement effect is as follows: Figure 3 As shown.

[0039] In summary, the embodiments of the present invention provide a 3D printing method for human organ donation for post-donation humanistic care. This method, without participating in any medical diagnosis, treatment or transplantation, replaces the original donor organ in the corresponding anatomical position in the donor's body after organ donation and is sutured together with the remains to restore the morphological integrity of the donor's body cavity, reflecting the humanistic dignity and commemorative significance of organ donation.

[0040] Those skilled in the art will understand that embodiments of the present invention can be provided as methods, systems, or computer program products. Therefore, the present invention can take the form of a completely hardware embodiment, a completely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, the present invention can take the form of a computer program product embodied on one or more computer-usable storage media (including, but not limited to, disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0041] This invention is described with reference to flowchart illustrations and / or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the invention. It will be understood that each block of the flowchart illustrations and / or block diagrams, and combinations of blocks in the flowchart illustrations and / or block diagrams, can be implemented by computer program instructions. These computer program instructions can be provided to a processor of a general-purpose computer, special-purpose computer, embedded processor, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, generate instructions for implementing the flowchart illustrations and / or block diagrams. Figure 1 One or more processes and / or boxes Figure 1 A device that provides the functions specified in one or more boxes.

[0042] These computer program instructions may also be stored in a computer-readable storage medium that can direct a computer or other programmable data processing device to function in a particular manner, such that the instructions stored in the computer-readable storage medium produce an article of manufacture including instruction means, which are implemented in a process Figure 1 One or more processes and / or boxes Figure 1 The function specified in one or more boxes.

[0043] These computer program instructions may also be loaded onto a computer or other programmable data processing equipment to cause a series of operational steps to be performed on the computer or other programmable equipment to produce a computer-implemented process, thereby providing instructions that execute on the computer or other programmable equipment for implementing the process. Figure 1 One or more processes and / or boxes Figure 1 The steps of the function specified in one or more boxes.

[0044] Any aspects of this invention not described in detail in the embodiments are well-known techniques to those skilled in the art. Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this invention and not to limit it. Although this invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of this invention without departing from the spirit and scope of this invention, and all such modifications and substitutions should be covered within the scope of the claims of this invention.

Claims

1. A method for 3D printing human organs for post-donation humanistic care, characterized in that, include: Acquire human organ imaging data; Based on the aforementioned human organ image data, 3D modeling of human organs is performed to generate a 3D model of human organs including a circumferential suture area, suture auxiliary holes, and suture guide grooves. The quality of the 3D models of the human organs was assessed. If the quality assessment is satisfactory, the 3D model of the human organ will be 3D printed.

2. The 3D printing method for human organs used in post-donation humanistic care as described in claim 1, characterized in that, The step of performing 3D modeling of human organs based on the aforementioned human organ image data, generating a 3D model of the human organ including a circular suture area, suture auxiliary holes, and suture guide grooves, includes: Based on the human organ image data, feature extraction is performed to obtain a modeling feature file; Based on the modeling feature file, 3D modeling of human organs is performed to generate preliminary 3D models of human organs. At the edge of the suture area corresponding to the preliminary 3D model of the human organ, a ring-shaped suture area is set, and the wall thickness of the ring-shaped suture area is thickened compared to the suture area. Within the circumferential suture area, multiple through holes are arranged at equal intervals along the edge line to form suture auxiliary holes; Grooves are set along the model surface between adjacent suture auxiliary holes to form suture guide grooves.

3. The 3D printing method for human organs used in post-donation humanistic care as described in claim 2, characterized in that, The quality assessment of the 3D model of the human organ includes: If the wall thickness of the circumferential suture area is less than the set first wall thickness, or the diameter of the suture auxiliary hole is less than the set diameter, or the wall thickness of the suture auxiliary hole is less than the set second wall thickness, or the maximum inscribed circle diameter of the cross-section of the suture guide groove is less than the set diameter, then the quality is deemed unqualified.

4. The 3D printing method for human organs used in post-donation humanistic care as described in claim 3, characterized in that, Also includes: Using the maximum inscribed sphere algorithm, a maximum sphere is fitted inside the structure at the edge of the suture auxiliary hole, and the diameter of this sphere is used as the local nominal wall thickness of the region.

5. The 3D printing method for human organs used in post-donation humanistic care as described in claim 3, characterized in that, Also includes: Along the axial direction of the suture guide groove, cross sections are cut at fixed intervals, and the maximum inscribed circle diameter of the cross section is calculated.

6. The 3D printing method for human organs used in post-donation humanistic care as described in claim 2, characterized in that, The quality assessment of the 3D model of the human organ includes: Traverse all edges of the 3D model of the human organ and count the number of times each edge is shared by a triangular facet. If an edge is shared by multiple triangular faces or multiple triangular faces are connected only by a single isolated vertex, it is considered to be of substandard quality.

7. The 3D printing method for human organs used in post-donation humanistic care as described in claim 2, characterized in that, The quality assessment of the 3D model of the human organ includes: Randomly select a starting face from the 3D model of the human organ, execute the seed filling algorithm, and traverse all faces connected by common edges; If any unmarked vertices or faces exist after the traversal is complete, the traversal is considered unqualified.

8. The 3D printing method for human organs used in post-donation humanistic care as described in claim 2, characterized in that, The quality assessment of the 3D model of the human organ includes: Actual shrinkage rate using the formula Calculate the actual shrinkage rate of the 3D model of the human organ along the three principal axes of length, width, and height. ;in, The maximum outer contour dimensions of the 3D model of the human organ along the three principal axes of length, width, and height. The maximum outer contour dimension of the surface point cloud in the modeling feature file along the three principal axes of length, width, and height; If the actual shrinkage rate of the 3D model of the human organ in the three main axes of length, width, and height is... If all values ​​are less than the set shrinkage rate threshold, the product is considered to be of acceptable quality. or, Calculate the Euclidean distance between the surface point cloud of the modeling feature file and the surface of the 3D model of the human organ; If the Euclidean distance is less than or equal to within the set tolerance range, the quality is deemed acceptable.

9. The 3D printing method for human organs used in post-donation humanistic care as described in claim 1, characterized in that, After 3D printing the 3D model of the human organ, the method further includes: The 3D printed human organ entity is placed based on the circumferential suture area, suture auxiliary hole, and suture guide groove.

10. The 3D printing method for human organs used in post-donation humanistic care as described in claim 9, characterized in that, The placement of the 3D-printed human organ entity based on the circumferential suture area, suture auxiliary hole, and suture guide groove includes: Within the circumferential suture area, sutures are passed through the suture auxiliary holes and fixed to the tissue surrounding the target organ. The suture path is then regulated by the suture guide groove to achieve the placement of the 3D printed human organ.

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