Solid water-in-oil type cosmetic

Abstract

The present invention provides a solid water-in-oil cosmetic, even if a vesicular composition is incorporated, the structure of the cosmetic itself is not destroyed, the stability over time is excellent, and the stability over time of the vesicular composition is also excellent. The solid water-in-oil cosmetic contains at least component (A) a vesicular composition, component (B) an oily gelator, and component (C) a lipophilic surfactant.

Description

Technical Field

[0001] This technology relates to a solid oil-in-water cosmetic. Background Technology

[0002] Spherical, closed endoplasmic reticulum vesicles (liposomes), formed in aqueous solvents through the action of amphiphilic substances such as phospholipids and surfactants, are widely used as skincare base materials for delivering active ingredients in the pharmaceutical field and for retaining stratum corneum in the cosmetic field. Furthermore, water-in-oil cosmetics are known to have advantages due to their continuous oil phase structure: they retain a water-locking oil film on the skin, providing long-term protection against dryness, and they can stably retain water-soluble pharmaceuticals and cosmetic ingredients whose stability is a concern. Based on this, the formulation technology of vesicle compositions into water-in-oil cosmetics has attracted attention.

[0003] For example, Patent Document 1 discloses a water-in-oil emulsion for topical skin application, characterized by containing organically modified clay minerals and phospholipid hydroxide, and the phospholipid hydroxide being contained in the aqueous phase in the form of microspheres. Patent Document 1 also discloses a technique that improves the transdermal absorption of water-soluble active ingredients while simultaneously providing a water-in-oil emulsion.

[0004] Existing technical documents

[0005] Patent documents

[0006] Patent Document 1: Japanese Patent Application Publication No. 2007-308380 Summary of the Invention

[0007] However, as mentioned above, there are concerns about reduced occlusive properties and worsened dryness in liquid water-in-oil cosmetics with high water content. Therefore, a solid water-in-oil cosmetic, similar to a balm, is desired. However, when vesicle compositions are incorporated into solid water-in-oil cosmetics, the cosmetic itself is maintained as a solid external phase (oil phase) by oils and oily gelling agents. This results in a phenomenon known as "liquid drainage," where the internal phase (aqueous phase) and oils seep out, preventing the cosmetic from solidifying. This can be attributed to the surfactants in the vesicle compositions hindering the solidification of the gelling agents. The oils fail to solidify and seep into the aqueous phase, leading to instability in the dispersion of the aqueous phase, further merging of the aqueous phase, and ultimately, seepage from the aqueous phase into the oil phase. Currently, there are no reported studies on the formulation of solid water-in-oil cosmetics containing vesicle compositions.

[0008] The main objective of this technology is to provide a technology related to solid water-in-oil cosmetics, which, even when combined with vesicle compositions, does not have its structure destroyed, exhibits excellent long-term stability, and the vesicle compositions also exhibit excellent long-term stability.

[0009] The inventors of this application conducted in-depth research to solve the aforementioned problems and discovered that, in solid oil-in-water cosmetics containing vesicle compositions, by combining an oily gelling agent and a lipophilic surfactant, the structure of the cosmetic itself will not be destroyed even when combined with the vesicle composition, resulting in a solid oil-in-water cosmetic with excellent long-term stability, and the vesicle composition also exhibits excellent long-term stability, thus completing this technology.

[0010] That is, this technology provides:

[0011] A solid, water-in-oil cosmetic product, comprising at least:

[0012] Component (A) Vesicle composition,

[0013] Ingredient (B) Oily gelling agent, and

[0014] Component (C) is an lipophilic surfactant.

[0015] Furthermore, this technology provides the solid oil-in-water cosmetic, wherein component (A) is a liposome composition.

[0016] Furthermore, this technology provides the aforementioned solid oil-in-water cosmetic.

[0017] Component (A) is a liposome composition containing at least:

[0018] Component (a1) Phospholipids,

[0019] Component (a2) Sterols, and

[0020] Component (a3) ​​Polyol.

[0021] Furthermore, this technology provides the solid oil-in-water cosmetic, wherein ingredient (B) contains at least (b1) wax.

[0022] Furthermore, this technology provides the solid oil-in-water cosmetic, wherein the content of the ingredient (b1) is 1 to 30% by mass relative to the total amount of the cosmetic.

[0023] In addition, this technology provides the solid oil-in-water cosmetic, wherein ingredient (B) contains an oily gelling agent other than wax (b1) and wax (b2).

[0024] Furthermore, this technology provides the solid oil-in-water cosmetic, wherein the component (b2) is at least one selected from the group consisting of dextrin fatty acid esters, sucrose fatty acid esters, inulin fatty acid esters, 12-hydroxystearic acid, metal soaps, organic modified clay minerals, amino acid-based gelling agents, and inorganic powders.

[0025] Furthermore, this technology provides the solid oil-in-water cosmetic, wherein the component (b2) is an inorganic powder.

[0026] In addition, this technology provides the solid oil-in-water cosmetic, which further contains component (D) fatty acid glycerides (wherein component (C) is excluded).

[0027] Furthermore, this technology provides a solid oil-in-water cosmetic in which the water content is less than 80% by mass relative to the total amount of the cosmetic.

[0028] In addition, this technology provides the solid oil-in-water type cosmetic, wherein the needle penetration load value of the cosmetic is 50 to 500 gf.

[0029] In addition, this technology provides the solid oil-in-water type cosmetic, which is a skin care cosmetic.

[0030] In addition, this technology provides the solid oil-in-water type cosmetic, which is a lip cosmetic.

[0031] According to this technology, in solid water-in-oil cosmetics containing vesicle compositions, by combining an oily gelling agent and a lipophilic surfactant, the structure of the cosmetic itself will not be destroyed even when combined with the vesicle composition, thus providing solid water-in-oil cosmetics with excellent long-term stability, and the vesicle composition also has excellent long-term stability.

[0032] Furthermore, the solid oil-in-water cosmetics based on this technology also excel in terms of user experience, such as occlusion, ease of application (i.e., good application quality), and good spreadability. Detailed Implementation

[0033] The present invention will now be described in detail. However, the present invention is not limited to the embodiments described below. In this specification, the range “X~Y” includes the values ​​X and Y before and after it, meaning “above X and below Y”. Furthermore, the upper limit (below) and lower limit (above) of each numerical range (~) can be arbitrarily combined as needed.

[0034] This technology relates to a solid water-in-oil cosmetic, which contains at least a vesicle composition, an oily gelling agent, and a lipophilic surfactant.

[0035] [Solid oil-in-water cosmetics]

[0036] The solid water-in-oil cosmetics involved in this technology refer to water-in-oil cosmetics that are solid at room temperature (25°C). "Solid at room temperature (25°C)" means that the cosmetic, when filled into a container and left to stand, does not exhibit any flowability. Furthermore, water-in-oil cosmetics refer to cosmetics with an oil phase on the outside and an aqueous phase on the inside. The oil phase contains oily components (e.g., oils, oily gelling agents, etc.), and the aqueous phase contains aqueous components (e.g., vesicle compositions, water, alcohols, etc.). Any state in which an aqueous phase is dispersed within the oil phase is acceptable, including water-in-oil emulsion cosmetics. From the viewpoint of the long-term stability of such water-in-oil cosmetics and vesicle compositions, the solid water-in-oil cosmetics involved in this technology are preferably solid water-in-oil emulsion cosmetics.

[0037] [Component (A) Vesicle Composition]

[0038] In this technology, the vesicle composition of component (A) refers to a closed endoplasmic reticulum having a bilayer membrane structure, including vesicle compositions obtained by dispersing the vesicle composition in an aqueous solvent as a vesicle composition dispersion. Furthermore, the "vesicle composition" involved in this technology includes "monolayer vesicles" composed of a single-layer bilayer membrane structure and "multilayer vesicles" composed of multiple-layer bilayer membrane structures. The multilayer vesicles are those observed as a Malta cross pattern under a polarizing microscope, and as another observation method, they refer to multilayer vesicles that can also be observed using a transmission electron microscope. In this technology, multilayer vesicles are more preferred. By employing multilayer vesicles, compared to monolayer vesicles, more active ingredients and agents (preferably oil-soluble active ingredients and / or agents) can be encapsulated. Furthermore, skin effects from vesicle components such as phospholipids and sterols, described later, can be expected, making this technology even more preferred.

[0039] The vesicle composition used in this technology is not particularly limited as long as it is a vesicle composition commonly used in cosmetics, topical skin agents, etc., and any vesicle composition can be used. The vesicle compositions used in this technology can be classified into nonionic vesicles, anionic vesicles, and cationic vesicles based on the ionicity of the amphiphilic substance used.

[0040] The nonionic vesicles used in this technology are composed of nonionic surfactants containing hydroxyl groups (-OH), ether bonds (-O-), etc., within their hydrophilic groups that do not dissociate into ions even when dissolved in water (do not become ions). Regarding the nonionic surfactants used in this technology, any commonly used nonionic surfactants in cosmetics can be used without particular limitation; however, from the viewpoint of forming vesicle compositions, polyoxyethylene sterol ethers and sucrose fatty acid esters are preferred, for example.

[0041] From the viewpoint of the stability of the vesicle composition over time, the nonionic vesicles used in this technology are preferably composed of one or more of the following groups, in addition to the aforementioned nonionic surfactants: sterols, monoalkyl glycerols, and sphingosine such as ceramides.

[0042] The anionic vesicles used in this technology are composed of amphoteric or anionic surfactants that dissociate in water and have hydrophilic groups exhibiting anionicity, as well as hydrophobic groups such as fatty acids. There are no particular limitations as long as the composition possesses anionicity. Regarding the amphoteric or anionic surfactants used in this technology, any surfactant commonly used in cosmetics can be used without particular limitation, but from the viewpoint of forming vesicle compositions, phospholipids and acylglutamate salts are preferred, for example. Examples of acylglutamate salts include: sodium dilauroyl glutamate lysine, N-lauroyl-L-glutamate, N-myristoyl-L-glutamate, N-palmitoyl-L-glutamate, N-stearoyl-L-glutamate, and N-cocoa fatty acid acyl-L-glutamate.

[0043] From the viewpoint of the stability of the vesicle composition over time, the anionic vesicles used in this technology are preferably composed of one or more of the following groups, in addition to the aforementioned anionic surfactants: sterols, monostearate glycerol ethers, and sphingosine such as ceramides.

[0044] The cationic vesicles used in this technology are composed of cationic surfactants that dissociate in water and possess both a hydrophilic group exhibiting cationic properties and a hydrophobic group such as fatty acids. There are no particular limitations as long as the surfactant possesses cationic properties in the composition. Regarding the cationic surfactants used in this technology, any cationic surfactant commonly used in cosmetics can be used without particular limitation; examples include quaternary ammonium salts, tertiary amines, fatty acid amide amines and their neutralizations, ester amines, etc. Furthermore, examples of structures possessing hydrophobic groups, such as fatty acids, include mono-long-chain alkyl types, di-long-chain alkyl types, ethylene oxide addition types, etc.; examples of hydrophilic groups exhibiting cationic properties include ammonium salts, benzalkonium chloride salts, etc.; and examples of counterions include chloride ions, bromide ions, methyl sulfate ions, ethyl sulfate ions, etc.

[0045] In this technology, from the viewpoint of forming a vesicle composition, a two-long-chain cationic surfactant is preferred as the cationic surfactant constituting the cationic vesicle, and a two-long-chain cationic surfactant having ester bonds in both fatty acid chains and the hydrophobic chain is more preferred. Furthermore, from the viewpoint of the long-term stability of the vesicle composition, a two-long-chain acylalkyl hydroxyalkyl ammonium is further preferred, and one or more cationic surfactants selected from the group consisting of dicocoyl ethyl hydroxyethyl methyl sulfate and dipalmitoyl ethyl hydroxyethyl methyl sulfate are particularly preferred. Commercially available products include: a mixture of dicocoyl ethyl hydroxyethyl methyl sulfate, DEHYQUART L80T (manufactured by BASF, 80% purity), a mixture of dipalmitoyl ethyl hydroxyethyl methyl sulfate, DEHYQUART AU56 / G, and DEHYQUART C4046 (both manufactured by BASF), etc., and one or more can be used in combination.

[0046] Mutually

[0047] Regarding the overall mass of the solid water-in-oil cosmetic, the content of the component (A) with a bimolecular membrane structure and closed endoplasmic reticulum is not particularly limited, and can be freely set as long as it does not impair the function and effect of this technology. Relative to the overall mass of the solid water-in-oil cosmetic, the lower limit of the content of the component (A) with a bimolecular membrane structure and closed endoplasmic reticulum is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, even more preferably 0.2% by mass or more, and particularly preferably 0.3% by mass or more. Relative to the overall mass of the solid water-in-oil cosmetic, the upper limit of the content of the component (A) with a bimolecular membrane structure and closed endoplasmic reticulum is preferably 10% by mass or less, more preferably 5% by mass or less, further preferably 3% by mass or less, and particularly preferably 2.5% by mass or less. From the perspective of the stability over time, occlusion, and user experience of solid water-in-oil cosmetics and vesicle compositions, the content of the component of the solid water-in-oil cosmetic (A) having a bimolecular membrane structure and containing the closed endoplasmic reticulum is preferably 0.01 to 10% by mass, more preferably 0.05 to 5% by mass, further preferably 0.1 to 3% by mass, even more preferably 0.2 to 3% by mass, and particularly preferably 0.3 to 2.5% by mass, relative to the overall mass of the solid water-in-oil cosmetic.

[0048] <Liposome Composition>

[0049] The vesicle composition used in the solid oil-in-water cosmetics involved in this technology is not particularly limited, but from the viewpoints of the long-term stability, permeability, and moisturizing properties of the vesicle composition, a spherical closed endoplasmic reticulum, i.e., a liposome composition, formed by a phospholipid bilayer, is preferred. Liposomes can encapsulate active ingredients and agents within their membranes, and due to their high skin retention capacity, they can effectively exert the efficacy of active ingredients and agents, and can also exert the sustained high moisturizing effect brought by the phospholipid bilayer component. By using this liposome composition, the solid oil-in-water cosmetics of this technology can be endowed with higher permeability and moisturizing effect. From the viewpoints of the long-term stability of the liposome composition, the liposome composition used as the vesicle composition of this technology is more preferably a liposome composition containing at least component (a1) phospholipid, component (a2) sterols, and component (a3) ​​polyols.

[0050] (Component (a1) Phospholipids)

[0051] The phospholipid (a1) used in this technology is any phospholipid used as a constituent component of the liposome composition in this technology. There are no particular limitations as long as it is a phospholipid commonly used in cosmetics, topical skin agents, etc. Examples include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, etc. One or more of these can be selected and used in combination as needed. Furthermore, component (a1) can also be a composition containing one or more of the aforementioned phospholipids.

[0052] Examples of sources of ingredient (a1) include soybeans, egg yolks, sunflower seeds, microorganisms, marine organisms, and animal organs. Soybean-derived phospholipids are preferred. Examples of phospholipid-containing compositions include soybean lecithin (also known as "soybean lecithin"), egg yolk lecithin (also known as "egg yolk lecithin"), their hydrogenated forms, and lysophosphatidylcholine obtained by enzymatic lysing. Hydrogenated phospholipids are preferred, and hydrogenated soybean lecithin is more preferred. One or more of these can be used in combination as needed. Specific commercial products include HSL-70 (manufactured by YMC Corporation), NIKKOL Lecinol S-10E (manufactured by Nikko Chemicals Corporation), BASIS LS-60HR (manufactured by Nissin OILLIO GROUP Corporation), and egg yolk lysophosphatidylcholine LPC-1 (manufactured by Kewpie Corporation).

[0053] In this technology, the "PC purity" of component (a1) refers to the proportion (purity) of phosphatidylcholine (PC) contained in the phospholipid. The lower limit of the PC purity of component (a1) used in this technology is, for example, 60% or more, preferably 70% or more, more preferably 75% or more, further preferably 80% or more, and even more preferably 85% or more. The upper limit of the PC purity of component (a1) used in this technology is not particularly limited and can be, for example, 99% or less. Furthermore, PC purity can be analyzed using known methods such as HPLC (High Performance Liquid Chromatography) and GC (Gas Chromatography).

[0054] In this technology, the content of component (a1) is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the mass content of component (a1) relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, further preferably 0.2% by mass or more, and even more preferably 0.5% by mass or more. The upper limit of the mass content of component (a1) relative to the overall mass of the solid water-in-oil cosmetic is preferably 10% by mass or less, more preferably 5% by mass or less, and even more preferably 2% by mass or less. From the viewpoint of the long-term stability, permeability, and moisturizing properties of the liposome composition, the mass content of component (a1) relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 0.01 to 10% by mass, more preferably 0.1 to 5% by mass, further preferably 0.2 to 2% by mass, and even more preferably 0.5 to 2% by mass.

[0055] (Component (a2) Sterols)

[0056] The sterols (a2) used in this technology are sterols used together with component (a1) as constituents of the liposome composition, and contribute to the stability of the lipid bilayer structure in the liposome composition. As for the sterols (a2) used in this technology, there are no particular limitations as long as they are commonly used in cosmetics, topical skin agents, etc., and examples include cholesterol and phytosterols. One or more of them can be appropriately selected and used in combination as needed. The cholesterol used in this technology is generally refined from natural sources; cholesterol refined from any natural source can be used in this technology. Commercially available examples include Marine Cholesterol (manufactured by Nippon Suisan Co., Ltd.). As for the phytosterols used in this technology, any phytosterol generally classified as a phytosterol can be used; as constituents, phytosterols containing campesterol, sitosterol, stigmasterol, etc., are preferred. The above components can be obtained by extracting the germ of grains with organic solvents and removing the water-soluble portion, or commercially available products can be purchased and used. Examples of commercially available products include phytosterols (QI) (manufactured by Mitsubishi Chemical Foods Co., Ltd.).

[0057] In this technology, the content of component (a2) is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the mass content of component (a2) relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.01% by mass or more, more preferably 0.03% by mass or more, further preferably 0.05% by mass or more, and even more preferably 0.1% by mass or more. The upper limit of the mass content of component (a2) relative to the overall mass of the solid water-in-oil cosmetic is preferably 2% by mass or less, more preferably 1% by mass or less, and even more preferably 0.5% by mass or less. From the viewpoint of the long-term stability of the liposome composition, the mass content of component (a2) relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.01 to 2% by mass, more preferably 0.03 to 1% by mass, further preferably 0.05 to 1% by mass, even more preferably 0.05 to 0.5% by mass, and particularly preferably 0.1 to 0.5% by mass.

[0058] (Component (a3) ​​polyol)

[0059] The polyol (a3) ​​used in this technology has a structure with two or more hydroxyl groups within its molecule. In this technology, it contributes to the dispersibility and solubility of components (a1) and (a2), and by containing this component, the long-term stability of the liposome composition can be improved. The polyol (a3) ​​used in this technology is not particularly limited as long as it is a polyol commonly used in cosmetics or topical skin agents. For example, a polyol with an IOB value in the range of 1.8 to 5.5 can be used, and one or more can be selected and used in combination as needed. In this technology, from the viewpoint of long-term stability of the liposome composition, it is preferable to use a combination of components with an IOB value in the range of 1.8 to 3.5 and components with an IOB value in the range of 4.5 to 5.5.

[0060] Furthermore, the IOB value in this technique is based on an organic concept map (Fujita Mu, Prediction of Organic Compounds and Organic Concept Map, Chemical Field Vol. 11, No. 10 (1957) 719-715). More specifically, in this organic concept map, the physicochemical properties of a compound are defined as the degree of physical properties mainly generated by van der Waals forces as "organic" and the degree of physical properties mainly generated by electroaffinity as "inorganic". The IOB value is an indicator of the balance between inorganic and organic properties, expressed as IOB value = inorganic value / organic value. Compounds with a larger IOB value can be said to exhibit higher hydrophilicity and polarity.

[0061] Examples of polyols with an IOB value in the range of 1.8 to 3.5 include dipropylene glycol (IOB value = 1.8), 1,3-butanediol (IOB value = 2.5), 1,3-propanediol (IOB value = 3.3), and diglycerides (IOB value = 3.5). Examples of polyols with an IOB value in the range of 4.5 to 5.5 include glycerol (IOB value = 5.0) and sorbitol (IOB value = 5.0). Component (a3) ​​may be selected from one or more of the above-mentioned components as needed. From the viewpoint of the long-term stability of the liposome composition, a combination of dipropylene glycol and / or 1,3-butanediol with glycerol is preferred, and a combination of 1,3-butanediol with glycerol is more preferred.

[0062] In this technology, the content of ingredient (a3) ​​is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the mass content of ingredient (a3) ​​relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.5% by mass or more, more preferably 1% by mass or more, and even more preferably 4% by mass or more. The upper limit of the mass content of ingredient (a3) ​​relative to the overall mass of the solid water-in-oil cosmetic is preferably 30% by mass or less, more preferably 20% by mass or less, and even more preferably 10% by mass or less. From the viewpoint of the long-term stability of the liposome composition, the mass content of ingredient (a3) ​​relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 0.5 to 30% by mass, more preferably 1 to 20% by mass, and even more preferably 4 to 10% by mass.

[0063] As a component (a3) ​​in this technology, when using a combination of components with an IOB value in the range of 1.8 to 3.5 and components with an IOB value in the range of 4.5 to 5.5, the content of each polyol is not particularly limited, and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the content of polyols with an IOB value in the range of 1.8 to 3.5 relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, further preferably 1% by mass or more, and particularly preferably 2% by mass or more. The upper limit of the mass of polyols with an IOB value in the range of 1.8 to 3.5 relative to the overall mass of the solid water-in-oil cosmetic is preferably 10% by mass or less, more preferably 8% by mass or less, further preferably 6% by mass or less, and particularly preferably 5% by mass or less. The content of polyols with an IOB value in the range of 1.8 to 3.5, relative to the overall mass of the solid water-in-oil cosmetic, is preferably 0.05 to 10% by mass, more preferably 0.1 to 8% by mass, even more preferably 1 to 6% by mass, and particularly preferably 2 to 5% by mass.

[0064] Furthermore, relative to the overall mass of the solid water-in-oil cosmetic, the lower limit of the content of polyols with an IOB value in the range of 4.5 to 5.5 is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, further preferably 1% by mass or more, and particularly preferably 2% by mass or more. Relative to the overall mass of the solid water-in-oil cosmetic, the upper limit of the content of polyols with an IOB value in the range of 4.5 to 5.5 is preferably 10% by mass or less, more preferably 8% by mass or less, and further preferably 5% by mass or less. Specifically, relative to the overall mass of the solid water-in-oil cosmetic, the content of polyols with an IOB value in the range of 4.5 to 5.5 is preferably 0.05% to 10% by mass, more preferably 0.1% to 8% by mass, further preferably 1% to 5% by mass, and particularly preferably 2% to 5% by mass.

[0065] Furthermore, the ratio of the contents of each polyol (polyol with an IOB value in the range of 1.8 to 3.5: polyol with an IOB value in the range of 4.5 to 5.5) is preferably 0.5 to 9.5: 9.5 to 0.5, and more preferably 1 to 5: 5 to 1.

[0066] Since the vesicle (liposome) composition involved in this technology exists in a dispersed state in an aqueous solvent as described above, the aqueous solvent may contain one or more aqueous components selected from water, lower alcohols (preferably with 1 to 4 carbon atoms, such as EtOH, etc.). Furthermore, in addition to components (A) to (C), which are essential components, one or more components selected from oils, surfactants, water-soluble polymers, various cosmetic active ingredients, fragrances, etc., may be appropriately contained, without impairing the structure of the vesicle (liposome) composition.

[0067] The method for manufacturing the vesicle (liposome) composition involved in this technology is not particularly limited, and it can be prepared by commonly used manufacturing methods. In the case of the liposome composition, for example, components (a1) to (a3) ​​are preheated and uniformly mixed, and the heated aqueous component is added to it while stirring to obtain a liposome composition dispersion. The mixing temperature at this time is not particularly limited, and examples include 60 to 80°C. Furthermore, the resulting liposome composition dispersion can then be subjected to high-pressure treatment. By observing the dispersion obtained in this way under a polarized light microscope under orthogonal Nicol crosses, the formation of the liposome composition can be confirmed by confirming the Malta cross pattern.

[0068] The average particle size of the vesicle (liposome) composition involved in this technology is not particularly limited, but from the viewpoint of the stability, permeability and moisturizing properties of the vesicle (liposome) composition over time, it is preferably 50 to 600 nm, more preferably 70 to 500 nm. In addition, the average particle size can be measured using a real-time nanoparticle size measuring device, DelsaMax CORE (manufactured by Beckman Coulter Co., Ltd.).

[0069] [Ingredient (B) Oily gelling agent]

[0070] The oily gelling agent (B) used in this technology is an ingredient that prevents the water-in-oil cosmetic from becoming runny. By containing this ingredient, in addition to solidifying the water-in-oil cosmetic and improving the long-term stability of the water-in-oil cosmetic and the vesicle composition, it also improves the user experience, including occlusion, application feel, and spreadability. Depending on its gelation mechanism, the oily gelling agent (B) used in this technology can be classified as an oily gelling agent other than waxes (b1) and (b2). From the viewpoints of solidification of the water-in-oil cosmetic, long-term stability of the water-in-oil cosmetic and the vesicle composition, occlusion, and user experience, the oily gelling agent (B) used in this technology preferably contains at least wax (b1), and more preferably contains an oily gelling agent other than waxes (b1) and (b2).

[0071] The content of component (B) is not particularly limited relative to the overall mass of the solid water-in-oil cosmetic and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the content of component (B) relative to the overall mass of the solid water-in-oil cosmetic is preferably 1% by mass or more, more preferably 2% by mass or more, further preferably 3% by mass or more, and particularly preferably 6% by mass or more. The upper limit of the content of component (B) relative to the overall mass of the solid water-in-oil cosmetic is preferably 30% by mass or less, more preferably 25% by mass or less, further preferably 22% by mass or less, and even more preferably 18% by mass or less. From the viewpoint of the curing of the water-in-oil cosmetic and the long-term stability of the water-in-oil cosmetic and the vesicle composition, the content of component (B) relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 1 to 30% by mass, more preferably 2 to 25% by mass, further preferably 3 to 22% by mass, even more preferably 6 to 22% by mass, and particularly preferably 6 to 18% by mass.

[0072] Furthermore, the mass ratio (a1) / (B) of component (a1) to component (B) is not particularly limited and can be freely set as long as it does not impair the function and effect of the present invention. The lower limit of (a1) / (B) is preferably 0.01 or more, more preferably 0.02 or more, and even more preferably 0.022 or more. The upper limit of (a1) / (B) is preferably 0.3 or less, more preferably 0.2 or less, even more preferably 0.17 or less, and particularly preferably 0.1 or less. From the viewpoint of the curing of water-in-oil cosmetics and the long-term stability of the water-in-oil cosmetics and the vesicle composition, (a1) / (B) is preferably 0.01 to 0.3, more preferably 0.02 to 0.2, even more preferably 0.022 to 0.17, and particularly preferably 0.022 to 0.1.

[0073] (Component (b1) wax)

[0074] Wax is a lipophilic fatty compound with a low melting temperature ranging from room temperature to around 100°C. Utilizing this property, by reaching its melting temperature and mixing it with an oil, a microscopically homogeneous mixture is formed. Upon returning to room temperature, the wax recrystallizes, forming a lattice-like structure where plate-like molecular crystals are physically interlocked, thereby gelling. Examples of waxes used as component (b1) in this technology include: polyethylene wax, ethylene-propylene copolymer, paraffin wax, Fischer-Tropsch wax, microcrystalline wax, pure ceresin wax, and other hydrocarbon waxes (synthetic waxes); rice bran wax, carnauba wax, beeswax, lanolin wax, candelilla wax, and other natural waxes. One or more of these can be used as needed.

[0075] From the perspective of the curing, sealing properties and user experience of the solid oil-in-water cosmetics involved in this technology, hydrocarbon waxes are preferred, more preferably containing two or more hydrocarbon waxes, and even more preferably selected from one or more of paraffin wax, microcrystalline wax and rice bran wax.

[0076] The content of component (b1) is not particularly limited relative to the overall mass of the solid water-in-oil cosmetic and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the content of component (b1) relative to the overall mass of the solid water-in-oil cosmetic is preferably 1% by mass or more, more preferably 2% by mass or more, and even more preferably 4% by mass or more. The upper limit of the content of component (b1) relative to the overall mass of the solid water-in-oil cosmetic is preferably 30% by mass or less, more preferably 20% by mass or less, and even more preferably 15% by mass or less. From the viewpoint of the curing of the water-in-oil cosmetic and the long-term stability of the water-in-oil cosmetic and the vesicle composition, the content of component (b1) relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 1 to 30% by mass, more preferably 2 to 20% by mass, even more preferably 4 to 20% by mass, and particularly preferably 4 to 15% by mass.

[0077] When a liposome composition is included as a vesicle composition of a solid water-in-oil cosmetic according to this technology, the mass ratio (a1) / (b1) of component (a1) to component (b1) is not particularly limited, and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of (a1) / (b1) is preferably 0.005 or more, more preferably 0.01 or more, and even more preferably 0.02 or more. The upper limit of (a1) / (b1) is preferably 0.5 or less, more preferably 0.25 or less, and even more preferably 0.2 or less. From the viewpoint of the curing of the water-in-oil cosmetic and the long-term stability of the water-in-oil cosmetic and the vesicle composition, (a1) / (b1) is preferably 0.005 to 0.5, more preferably 0.01 to 0.25, and even more preferably 0.02 to 0.2.

[0078] (Component (b2) is an oily gelling agent other than wax)

[0079] Oil-based gelling agents other than waxes are gelling agents in which molecules dispersed in an oil form a three-dimensional network structure or aggregate through physical interactions such as hydrogen bonds or van der Waals forces, and gel by taking up the oil. As for the gelling agent other than wax used in this technology (b2), there are no particular limitations as long as it is a gelling agent commonly used in cosmetics or topical skin agents. Examples include: inorganic powders, sugar fatty acid esters, metal soaps, organically modified clay minerals, amino acid-based gelling agents, glyceryl low-polyester, 12-hydroxystearic acid, etc. One or more of the above ingredients can be selected as needed. From the viewpoint of the long-term stability and user experience of solid water-in-oil cosmetics and vesicle compositions, it is preferable to use at least one selected from the group consisting of dextrin fatty acid esters, sucrose fatty acid esters, inulin fatty acid esters, 12-hydroxystearic acid, metal soaps, organically modified clay minerals, amino acid-based gelling agents, and inorganic powders. More preferably, it is preferable to use at least one selected from the group consisting of dextrin fatty acid esters, sucrose fatty acid esters, inulin fatty acid esters, 12-hydroxystearic acid, organically modified clay minerals, and inorganic powders. Even more preferably, it is preferable to use at least one selected from the group consisting of dextrin fatty acid esters, organically modified clay minerals, and inorganic powders. Even more preferably, it is preferable to use inorganic powders such as silica. Particularly preferred, it is preferable to use inorganic powders that have undergone hydrophobic treatment.

[0080] From the viewpoints of curing water-in-oil cosmetics, the long-term stability of the vesicle composition, its sealing properties, and user experience, silica is preferred as the inorganic powder used in this technology. Silica is high-purity silica microparticles. By using silica, the solidification of water-in-oil cosmetics can be maintained more stably, and an excellent user experience can be provided. The silica used in this technology is not limited to spherical or irregular shapes, the presence or absence of pores, or surface treatment, as long as it is silica that achieves the desired effect. From the viewpoints of curing, sealing properties, and user experience of water-in-oil cosmetics, fumed silica (gas-phase silica) with a specific surface area of ​​100 m² is preferred. 2 It must be above / g and be non-porous.

[0081] The inorganic powder used in this technology can also be a hydrophobically treated inorganic powder. From the viewpoint of curing, sealing, and user experience of water-in-oil cosmetics, hydrophobically treated silica is preferred. Hydrophobically treated silica is formed by replacing a portion of the hydrophilic groups covering the surface of silica with dimethylcyclosilyl, trimethylsilyl, etc., thereby improving its dispersibility in various oils. Examples of hydrophobic treatment methods include: dimethylsilylation using dimethyldichlorosilane, trimethylsilylation using trimethylchlorosilane or hexamethyldisilazane, octylsilylation using octyltrichlorosilane, organosilicon treatment using dimethylpolysiloxane or methylhydropolysiloxane, and application treatment using metal soap compounds. In this technology, dimethylsilylated silica is particularly preferred as the hydrophobically treated silica. Commercially available products can be used for hydrophobic treatment of silica. Examples of commercially available products include: AEROSIL 380S (manufactured by Aerosil Corporation of Japan, average particle size: 5-7nm), AEROSIL 200 (manufactured by Aerosil Corporation of Japan, average particle size: 10-15nm), AEROSIL R972 (manufactured by Aerosil Corporation of Japan, average particle size: 16nm), and AEROSIL R976S (manufactured by Aerosil Corporation of Japan, average particle size: 5-10nm).

[0082] Examples of dextrin fatty acid esters used in this technology include: caprylic dextrin ester, lauric dextrin ester, myristic dextrin ester, palmitic dextrin ester, palmitic acid / 2-ethylhexanoic acid dextrin ester, stearic acid dextrin ester, palmitic acid / stearic acid dextrin ester, oleic acid dextrin ester, behenic acid dextrin ester, coconut oil fatty acid dextrin ester, etc.; sucrose stearate (sucrose stearate), sucrose palmitate, etc.; oligofructose fatty acid esters such as oligofructose stearate; inulin fatty acid esters such as inulin stearate, etc. Commercially available dextrin fatty acid esters can be used. Examples of commercially available dextrin fatty acid esters include: Rheopearl (registered trademark) KL2 (palmitoyl dextrin ester), Rheopearl TT2 ((palmitoyl / ethylhexanoic acid) dextrin ester), and Rheopearl MKL2 (myristate dextrin ester) manufactured by Chiba Flour Co., Ltd.; and Rheopearl ISK2 (stearic acid inulin ester).

[0083] Examples of metal soaps used in this technology include: aluminum stearate, magnesium stearate, calcium stearate, calcium palmitate, lithium 2-ethylhexanoate, aluminum 12-hydroxystearate, etc.

[0084] Examples of organically modified clay minerals used in this technology include those obtained by replacing transforming cations between the crystal layers of clay minerals such as montmorillonite, saponite, lithium montmorillonite, and bentonite with organic polar compounds or organic cations. Specifically, examples include: dimethyldistearate ammonium lithium montmorillonite, dimethyldistearate ammonium bentonite, benzyl dimethyldistearate ammonium lithium montmorillonite, distearate dimethylammonium lithium montmorillonite, octadecyl dimethylammonium salt modified montmorillonite, octadecyl dimethyl benzyl ammonium salt modified montmorillonite, and hexadecyl dimethylammonium salt modified montmorillonite.

[0085] Examples of amino acid-based gelling agents used in this technology include: lauroyl glutamate stearamide, N-lauroyl-L-glutamate dibutyramide, N-2-ethylhexanoyl-L-glutamate dibutyramide, dihexanoyl lysine laurylamine salt, dihexanoyl lysine lauryl ester, dihexanoyl lysine lauroyl phenylalanine laurylamide, etc.

[0086] Examples of glycerol low-polyesters used in this technology include: glycerol-based low-polyester gelling agents synthesized from glycerol, eicosanoic acid, and behenic acid (referred to as (behenic acid / eicosanoic acid) glyceryl esters; the same applies to glycerol-based low-polyester gelling agents hereinafter); glyceryl 2-ethyloctadecanoic acid ester; glyceryl myristate tetradecanoic acid ester; glyceryl palmitate eicosanoic acid ester; glyceryl stearate hexadecanoic acid ester; glyceryl isostearate eicosanoic acid ester; glyceryl behenic acid octadecanoic acid ester; glyceryl 2-ethylhexanoate dodecanoic acid ester; and glyceryl 2-ethyloctadecanoic acid ester.

[0087] The content of ingredient (b2) is not particularly limited relative to the overall mass of the solid water-in-oil cosmetic and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the content of ingredient (b2) relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and even more preferably 0.5% by mass or more. The upper limit of the content of ingredient (b2) relative to the overall mass of the solid water-in-oil cosmetic is preferably 10% by mass or less, more preferably 5% by mass or less, even more preferably 3% by mass or less, and particularly preferably 2% by mass or less. From the viewpoint of the curing of the water-in-oil cosmetic and the long-term stability of the water-in-oil cosmetic and the vesicle composition, the content of ingredient (b2) relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 0.1 to 10% by mass, more preferably 0.3 to 5% by mass, even more preferably 0.5 to 3% by mass, and particularly preferably 0.5 to 2% by mass.

[0088] When a vesicle composition containing a liposome composition is used as the solid water-in-oil cosmetic product involved in this technology, the mass ratio (a1) / (b2) of component (a1) to component (b2) is not particularly limited, and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of (a1) / (b2) is preferably 0.01 or more, more preferably 0.05 or more, and even more preferably 0.1 or more. The upper limit of (a1) / (b2) is preferably 3 or less, more preferably 2 or less, and even more preferably 1 or less. From the viewpoint of the curing of the water-in-oil cosmetic product and the time stability of the water-in-oil cosmetic product and the liposome composition, (a1) / (b2) is preferably 0.01 to 3, more preferably 0.05 to 2, and even more preferably 0.1 to 1.

[0089] When an oily gelling agent other than component (b1) wax and component (b2) wax is included as component (B), the mass ratio (b1) / (b2) of component (b1) to component (b2) is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of (b1) / (b2) is preferably 1 or more, more preferably 2 or more. The upper limit of (b1) / (b2) is preferably 40 or less, more preferably 20 or less, and even more preferably 15 or less. From the viewpoint of curing of water-in-oil cosmetics and the long-term stability of the water-in-oil cosmetic and the vesicle composition, (b1) / (b2) is preferably 1 to 40, more preferably 2 to 20, and even more preferably 2 to 15.

[0090] [Component (C) Lipophilic surfactant]

[0091] The lipophilic surfactant (C) used in this technology contributes to the dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase, and further significantly improves its long-term stability. The lipophilic surfactant (C) used in this technology is not particularly limited to any lipophilic surfactant commonly used in cosmetics, topical skin agents, etc. However, from the viewpoint of improving the dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase and the long-term stability of solid water-in-oil cosmetics and vesicle compositions, a lipophilic surfactant with an HLB of 2 to 7 is preferred, and a lipophilic surfactant with an HLB of 2 to 6 is more preferred.

[0092] Examples of lipophilic surfactants with an HLB of 2-7 used in this technology include: diglyceride monostearate, diglyceride monooleate, diglyceride dioleate, diglyceride monoisostearate, tetraglyceride monostearate, tetraglyceride monooleate, tristearate hexaglyceride, trioleate decaglyceride, pentastearate decaglyceride, pentastearate decaglyceride, pentaisostearate decaglyceride, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, sorbitan sesquistearate, sorbitan trioleate, sorbitan monoisostearate, sorbitan sesquistearate, sorbitan monoisostearate, sorbitan sesquistearate, polyoxyethylene (3) castor oil, polyoxyethylene (10) castor oil, polyoxyethylene Hydrogenated castor oil (5) of polyethylene (10) hydrogenated castor oil, polyethylene glycol (1E.O.) monostearate, polyethylene glycol (2E.O.) monostearate, polyethylene glycol (4E.O.) monostearate, polyethylene glycol (2E.O.) monooleate, ethylene glycol monostearate, diethylene glycol stearate, polyoxyethylene-methyl polysiloxane copolymer, methyl polysiloxane-cetyl methyl polysiloxane-poly(ethylene oxide-propylene oxide) methyl polysiloxane copolymer, poly(ethylene oxide-propylene oxide) methyl polysiloxane copolymer, PEG-9 polydimethylsiloxane-ethyl polydimethylsiloxane, polyoxyethylene methyl siloxane-polyoxypropylene oil-based methyl siloxane-dimethyl siloxane copolymer, etc. One or more of these can be used as needed.

[0093] From the perspective of dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase and the long-term stability of solid water-in-oil cosmetics and vesicle compositions, organosilicon surfactants are preferred. Even if the organosilicon surfactant is a graft copolymer with an organopolysiloxane as the main chain and hydrophilic groups on the side chains, it can also contain linear block copolymers or cross-linked fusion compounds formed by alternating combinations of organopolysiloxane and hydrophilic groups. Specifically, examples of substances with a linear organopolysiloxane as the main chain and polyoxyalkylene groups on the side chains include: polyoxyalkylene-modified organopolysiloxanes and polyoxyalkylene-alkyl co-modified organopolysiloxanes. Examples of substances with hydrophilic groups include: polyether-modified organosilicones with polyether chains and polyglycerol-modified organosilicones with polyglycerol chains.

[0094] More specifically, examples include: polyglycerol fatty acid esters such as diglyceride monostearate (HLB 5.0), diglyceride monooleate (HLB 6.5), dioleate diglyceride (HLB 7.0), diglyceride monoisostearate (HLB 5.5), tetraglyceride monostearate (HLB 6.0), tetraglyceride monooleate (HLB 6.0), and tristearate hexaglyceride (HLB 2.5); sorbitan fatty acid esters such as sorbitan monostearate (HLB 4.7), sorbitan sesquistearate (HLB 4.2), sorbitan sesquiisostearate (HLB 4.0), and sorbitan sesquioleate (HLB 3.7); and polyoxyethylene-methylpolysiloxane copolymers (e.g., cosmetic ingredient labeling: PEG-10 polydimethylsiloxane (HLB 5.0)). 4.5), etc.), methyl polysiloxane-cetyl methyl polysiloxane-poly(ethylene oxide-propylene oxide) methyl polysiloxane copolymer (HLB 5.0), poly(ethylene oxide-propylene oxide) methyl polysiloxane copolymer (cosmetic full ingredient name: PEG / PPG-20 / 22 butyl ether polydimethylsiloxane) (HLB 7.0), PEG-9 polydimethylsiloxane-ethyl polydimethylsiloxane (HLB 4.0), lauryl PEG-9 polydimethylsiloxane-ethyl polydimethylsiloxane (HLB 3.0) and other polyether modified organosilicones, lauryl polyglycerol-3 polydimethylsiloxane-ethyl polydimethylsiloxane (HLB 3.0) and other polyglycerol modified organosilicones, poly(ethylene oxide-propylene oxide)-butene-methyl polysiloxane copolymer (HLB 6.0) and other block copolymer type organosilicon surfactants, may be used, one or more of these. More preferably, polyether-modified silicones and / or polyglycerol-modified silicones containing polyoxyethylene are preferred. As polyether-modified silicones, PEG-9 polydimethylsiloxane is even more preferred. As polyglycerol-modified silicones, lauryl polyglycerol-3 polydimethylsiloxane is even more preferred.

[0095] The content of ingredient (C) is not particularly limited relative to the overall mass of the solid water-in-oil cosmetic and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the content of ingredient (C) relative to the overall mass of the solid water-in-oil cosmetic is preferably 0.5% by mass or more, more preferably 1% by mass or more, and even more preferably 2% by mass or more. The upper limit of the content of ingredient (C) relative to the overall mass of the solid water-in-oil cosmetic is preferably 10% by mass or less, more preferably 8% by mass or less, even more preferably 7% by mass or less, and even more preferably 6% by mass or less. From the viewpoint of the dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase, and the long-term stability of the solid water-in-oil cosmetic and the vesicle composition, the content of ingredient (C) relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 0.5 to 10% by mass, more preferably 1 to 8% by mass, even more preferably 2 to 7% by mass, and even more preferably 2 to 6% by mass.

[0096] When a vesicle composition comprising a liposome composition is used in the solid water-in-oil cosmetic product of this invention, the mass ratio (a1) / (C) of component (a1) to component (C) is not particularly limited and can be freely set as long as it does not impair the function and effect of this invention. The lower limit of (a1) / (C) is preferably 0.005 or more, more preferably 0.01 or more, further preferably 0.05 or more, even more preferably 0.07 or more, and particularly preferably 0.1 or more. The upper limit of (a1) / (C) is preferably 1 or less, more preferably 0.5 or less, further preferably 0.4 or less, and particularly preferably 0.3 or less. From the viewpoints of dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase, and the time stability of solid water-in-oil cosmetics and vesicle compositions, (a1) / (C) is preferably 0.005 to 1, more preferably 0.01 to 0.5, even more preferably 0.05 to 0.4, even more preferably 0.07 to 0.3, and particularly preferably 0.1 to 0.3.

[0097] [Ingredient (D) Fatty acid glycerides]

[0098] Fatty acid glycerides are esters of fatty acids and glycerol. Furthermore, the fatty acid glyceride component (D) of this technology is a fatty acid glyceride other than the lipophilic surfactant component (C). The fatty acid glyceride component (D) used in this technology can further improve the dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase, as well as the long-term stability of solid water-in-oil cosmetics and vesicle compositions. The fatty acid glyceride component (D) used in this technology is not particularly limited to any fatty acid glyceride commonly used in cosmetics or topical skin agents, and examples include: polyglycerol-2-triisostearate, polyglycerol-2-diisostearate, polyglycerol-10-stearate, polyglycerol-10-diisostearate, polyglycerol-10-tristearate, polyglycerol-6-isostearate, polyglycerol-5-trioleate, polyglycerol-10-laurate, polyglycerol-2-isostearate, polyglycerol-2-diisostearate, and other polyglycerol fatty acid esters.

[0099] From the viewpoint of dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase and the time stability of solid water-in-oil cosmetics and vesicle compositions, component (D) is preferably a fatty acid glyceride having one or two hydroxyl groups in the molecule, more preferably polyglycerol-2-triisostearate or polyglycerol-2-diisostearate, and even more preferably polyglycerol-2-triisostearate and polyglycerol-2-diisostearate.

[0100] The content of ingredient (D) is not particularly limited relative to the overall mass of the solid water-in-oil cosmetic and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the content of ingredient (D) relative to the overall mass of the solid water-in-oil cosmetic is preferably 1% by mass or more, more preferably 5% by mass or more, and even more preferably 8% by mass or more. The upper limit of the content of ingredient (D) relative to the overall mass of the solid water-in-oil cosmetic is preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 15% by mass or less, and particularly preferably 12% by mass or less. From the viewpoint of the dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase, and the long-term stability of the solid water-in-oil cosmetic and the vesicle composition, the content of ingredient (D) relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 1 to 30% by mass, more preferably 5 to 20% by mass, even more preferably 5 to 15% by mass, and particularly preferably 8 to 12% by mass.

[0101] When a vesicle composition comprising a liposome composition is used in a solid, water-in-oil cosmetic product according to this technology, the mass ratio (a1) / (D) of component (a1) to component (D) is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of (a1) / (D) is preferably 0.0005 or more, more preferably 0.001 or more, further preferably 0.005 or more, and particularly preferably 0.01 or more. The upper limit of (a1) / (D) is preferably 0.5 or less, more preferably 0.2 or less, further preferably 0.1 or less, and particularly preferably 0.05 or less. From the viewpoints of dispersion stability / emulsification stability of the vesicle composition dispersion (aqueous phase) in the oil phase and the time stability of solid water-in-oil cosmetics and vesicle compositions, (a1) / (D) is preferably 0.0005 to 0.5, more preferably 0.001 to 0.2, even more preferably 0.005 to 0.1, and particularly preferably 0.01 to 0.05.

[0102] <Oily ingredients>

[0103] In the solid oil-in-water cosmetics involved in this technology, as the component containing the above-mentioned oily components (B) and (C) and forming an oil phase, the oily components commonly used in cosmetics, topical skin agents, etc., can be used within the scope of not hindering the effect of this technology.

[0104] Regardless of its form (liquid, paste, solid, etc.), volatility (volatile / non-volatile), or type (animal oil, vegetable oil, synthetic oil, etc.), the oils used in this technology can be any type, such as hydrocarbon oils, ester oils, grease oils, higher alcohols, silicone oils, fluorinated oils, and lanolin derivatives. From the viewpoint of dispersibility of oily components, liquid oils are particularly preferred, ester oils and / or hydrocarbon oils are more preferred, and ester oils and hydrocarbon oils are even more preferred. When using ester oils and hydrocarbon oils, from the viewpoint of the solidification, occlusion, and user experience of solid water-in-oil cosmetics, the ratio (ester oil / hydrocarbon oil) is preferably greater than 1, more preferably 1.1 or more, and even more preferably 1.2 or more. There is no particular upper limit, but the ratio (ester oil / hydrocarbon oil) is preferably 3 or less, more preferably 2.5 or less. The content of the liquid oil relative to the overall mass of the solid water-in-oil cosmetic is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of the mass content of the liquid oil relative to the overall mass of the solid water-in-oil cosmetic is preferably 20% by mass or more, more preferably 30% by mass or more, and even more preferably 50% by mass or more. The upper limit of the mass content of the liquid oil relative to the overall mass of the solid water-in-oil cosmetic is preferably 85% by mass or less, more preferably 80% by mass or less, and even more preferably 70% by mass or less. From the viewpoints of the time-dependent stability of the vesicle composition, the curing properties, occlusion properties, and user experience of the water-in-oil cosmetic, the mass content of the liquid oil relative to the overall mass of the solid water-in-oil cosmetic is preferably, for example, 20-85% by mass, more preferably 30-80% by mass, and even more preferably 50-70% by mass.

[0105] (hydrocarbon oil)

[0106] Examples of hydrocarbon oils used in this technology include liquid paraffin, heavy liquid isoparaffins, squalane, polyisobutylene, and polybutene. From the viewpoint of the curing, occlusive properties, and user experience of solid water-in-oil cosmetics, hydrocarbon oils with at least a specific viscosity are preferred. Specifically, the lower limit of the kinematic viscosity at 98.9°C is preferably 100 mm⁻¹. 2 / s or higher, preferably 200mm 2 / s or higher. The preferred upper limit is 5,000 mm. 2 / s or less, preferably 2,000 mm 2 / s or less, and more preferably 1,000 mm 2 / s or less, with 500mm being particularly preferred. 2 / s or less. The hydrocarbon oil used in this technology can be a commercially available product. Examples of commercially available products include: PARLEAM 18 (average carbon number 72 / average molecular weight: 1,000 / kinematic viscosity 290 mmHg at 98.9°C). 2 / s), PARLEAM24 (average carbon number 96 / average molecular weight: 1,350 / kinematic viscosity 740 mmHg at 98.9°C) 2 / s), PARLEAM46 (average carbon number 184 / average molecular weight: 2,650 / kinematic viscosity at 98.9℃: 5,000 mm²) 2 / s (The above are manufactured by Nippon Oil Company).

[0107] The ratio of hydrocarbon oil to component (B) oily gelling agent used in this technology (hydrocarbon oil / component (B) oily gelling agent) is not particularly limited and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of (hydrocarbon oil / component (B) oily gelling agent) is preferably 1 or more, more preferably 1.5 or more, and even more preferably 2 or more. The upper limit of (hydrocarbon oil / component (B) oily gelling agent) is preferably 10 or less, more preferably 8 or less, and even more preferably 5 or less. From the viewpoint of the curing, sealing properties, and user experience of solid oil-in-water cosmetics, the ratio of (hydrocarbon oil / component (B) oily gelling agent) is preferably 1 to 10, more preferably 1.5 to 8, and even more preferably 2 to 5.

[0108] The ratio of hydrocarbon oil to component (b1) wax used in this technology is not particularly limited, and can be freely set as long as it does not impair the function and effect of this technology. The lower limit of (hydrocarbon oil / component (b1) wax) is preferably 1 or more, more preferably 2 or more. The upper limit of (hydrocarbon oil / component (b1) wax) is preferably 15 or less, more preferably 10 or less, and even more preferably 8 or less. From the viewpoint of the curing, sealing properties and user experience of solid oil-in-water cosmetics, (hydrocarbon oil / component (b1) wax) is preferably 1 to 15, more preferably 1 to 10, and even more preferably 2 to 8.

[0109] (ester oil)

[0110] Examples of ester oils used in this technology include: diisostearyl malate, isopropyl myristate, isopropyl palmitate, triglycerides (ethylhexanoate), octyl dodecyl myristate, propylene glycol didecanoate, cetyl 2-ethylhexanoate, 2-ethylhexyl hydroxystearate, pentaerythritol tetraisostearate, octyl dodecyl stearyl oxystearate, and 2-ethylhexyl p-methoxycinnamate. Furthermore, from the viewpoint of sealing and usability, it is preferable to contain at least an ester oil with a specific viscosity or an ester oil with a molecular weight of 500 or more. Specifically, the viscosity at 30°C is preferably 1,000 mPa·s or more, and more preferably an ester oil with a molecular weight of 600 or more. There are no particular limitations as long as the ester oil meets these viscosity and molecular weight requirements; examples include diisostearyl malate. From the viewpoints of sealing and user experience, the content of ester oil with a specific viscosity or with a molecular weight of 500 or more is preferably 30 to 80% by mass relative to the overall mass of the ester oil used in this technology, more preferably 30 to 70% by mass, and even more preferably 40 to 70% by mass.

[0111] <Other Ingredients>

[0112] In addition to the above-mentioned ingredients (A) to (D), the solid oil-in-water type cosmetics involved in this technology may also contain ingredients commonly found in cosmetics, such as powders, surfactants, water-based ingredients, oil-based ingredients, moisturizers, antioxidants, beauty ingredients, preservatives, pigments, fragrances, etc., within the range that does not impair the effect of this technology.

[0113] The aqueous component involved in this technology is water or a water-compatible liquid component, as long as it is a component that can be contained in cosmetics, quasi-pharmaceuticals, pharmaceuticals, etc. As for water, any water that can be contained in quasi-pharmaceuticals, pharmaceuticals, etc., can be used, such as: purified water, hot spring water, deep water, ordinary water, distilled water, ion-exchanged water, or plant-derived steam distilled water. As for water-compatible liquid components, examples include: lower alcohols such as ethanol, polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, polyoxypropylene diglyceride, and other epoxy alkyl derivatives, etc. One or more can be used as needed.

[0114] The upper limit of the water content involved in this technology is preferably 80% by mass or less, more preferably 70% by mass, further preferably 60% by mass, even more preferably 50% by mass or less, and from the viewpoint of sealing properties, it is more preferably 40% by mass or less, more preferably 30% by mass or less, even more preferably 20% by mass or less, and particularly preferably 15% by mass or less. Furthermore, the lower limit can be 0% by mass, but from the viewpoint of the long-term stability of solid water-in-oil cosmetics and vesicle compositions, it is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, further preferably 1% by mass or more, and particularly preferably 3% by mass or more.

[0115] The hardness of the solid water-in-oil cosmetics involved in this technology is not particularly limited. However, from the viewpoint of maintaining good long-term stability of the solid water-in-oil cosmetics while appropriately improving the user experience, such as the feel when picked up and the spreadability during application, the lower limit of the needle load value (gf) is preferably 50 gf or more, more preferably 100 gf or more, and the upper limit of the needle load value (gf) is preferably 500 gf or less, more preferably 300 gf or less. For example, 50 to 500 gf is preferred, and 100 to 300 gf is even more preferred. By keeping the needle load value (gf) within the above-mentioned range, a solid water-in-oil cosmetic can be obtained that is superior in terms of user experience, such as the feel when picked up and the spreadability during application, while still achieving the effects of this technology. In this technology, the needle load value is measured using a rheometer manufactured by Rheotech Corporation. Specifically, a disc-shaped adapter with a measurement temperature of 35℃, a range of 500gf, and a diameter of 10mm is used to perform the measurement by inserting the needle 2mm at a speed of 6cm / min.

[0116] The uses of the solid oil-in-water cosmetics involved in this technology are not particularly limited and can be used in general cosmetics. Preferably, they are applied to skincare or lip cosmetics (such as balms, lipsticks, and lip glosses) where the effects of this technology are further desired. Furthermore, methods of application include direct application, application with hands or fingers, etc.

[0117] The method for manufacturing the solid water-in-oil cosmetic of this technology can be carried out by commonly known methods. As for the manufacturing equipment, any ordinary dispersion-emulsification equipment such as a disperser is sufficient. For example, it can be obtained by heating and mixing components (B) to (D), adding preheated component (A) to it, mixing evenly, and then cooling.

[0118] In addition, this technology can also be configured as follows.

[0119] [1] A solid, water-in-oil cosmetic, comprising at least:

[0120] Component (A) Vesicle composition,

[0121] Ingredient (B) Oily gelling agent, and

[0122] Component (C) is an lipophilic surfactant.

[0123] [2] According to the solid oil-in-water cosmetic described in [1], the component (A) is a liposome composition.

[0124] [3] According to the solid oil-in-water cosmetic described in [2],

[0125] Component (A) is a liposome composition containing at least:

[0126] Component (a1) Phospholipids,

[0127] Component (a2) Sterols, and

[0128] Component (a3) ​​Polyol.

[0129] [4] In any one of [1] to [3], the solid oil-in-water cosmetic, said ingredient (B) contains at least ingredient (b1) wax.

[0130] [5] In any one of [1] to [4], the content of said ingredient (b1) is 1 to 30% by mass relative to the total amount of the cosmetic.

[0131] [6] A solid oil-in-water cosmetic according to any one of [1] to [5], wherein ingredient (B) contains an oily gelling agent other than ingredient (b1) wax and ingredient (b2) wax.

[0132] [7] According to the solid oil-in-water cosmetic of [6], the component (b2) is at least one selected from the group consisting of dextrin fatty acid ester, sucrose fatty acid ester, inulin fatty acid ester, 12-hydroxystearic acid, metal soap, organic modified clay mineral, amino acid gelling agent and inorganic powder.

[0133] [8] According to the solid oil-in-water cosmetic described in [7], the component (b2) is an inorganic powder.

[0134] [9] A solid oil-in-water cosmetic according to any one of [1] to [8], wherein the solid oil-in-water cosmetic further contains ingredient (D) fatty acid glycerides (wherein ingredient (C) is excluded).

[0135]

[10] According to the solid oil-in-water cosmetic of [9], the ingredient (D) is a fatty acid glyceride having one or two hydroxyl groups in the molecule.

[0136]

[11] In the solid oil-in-water cosmetic according to [9] or

[10] , the ingredient (D) is at least one selected from polyglycerol-2 triisostearate and polyglycerol-2 diisostearate.

[0137]

[12] In any one of [1] to

[11] , the solid oil-in-water cosmetic product, said component (C) is an organosilicon surfactant.

[0138]

[13] The solid oil-in-water cosmetic according to any one of [1] to

[12] has a water content of 80% by mass or less relative to the total amount of the cosmetic.

[0139]

[14] The solid oil-in-water cosmetic according to any one of [1] to

[13] has a water content of 50% by mass or less relative to the total amount of the cosmetic.

[0140]

[15] A solid oil-in-water cosmetic according to any one of [1] to

[14] , wherein the needle load value of the cosmetic is 50 to 500 gf.

[0141]

[16] The solid oil-in-water type cosmetic according to any one of [1] to

[15] is a skin care cosmetic.

[0142]

[17] A solid oil-in-water cosmetic according to any one of [1] to

[16] , wherein the cosmetic is a lip cosmetic.

[0143] Example

[0144] The following examples illustrate the present technology in a more detailed manner. However, these examples do not limit the scope of the present technology in any way.

[0145] Examples 1-11, Comparative Example 1: Solid oil-in-water cosmetics (lip cosmetics)

[0146] In Table 1, solid oil-in-water cosmetics (lip cosmetics) of the examples and comparative examples were manufactured using the manufacturing methods shown below. For the obtained solid oil-in-water cosmetics (lip cosmetics), the following evaluation methods / judgment criteria were used to evaluate / judge "I. (Solid oil-in-water cosmetic) needle load value", "II. (Solid oil-in-water cosmetic) stability immediately after manufacturing", "III. (Solid oil-in-water cosmetic) stability over time (50°C / 1M)", and "IV. Stability of vesicles (liposomes)". The results are shown in Table 1. Furthermore, for the obtained solid oil-in-water cosmetics (lip cosmetics), the following evaluation methods / judgment criteria were used to evaluate / judge "V. Occlusivity, VI. Handling feel, and VII. Spreadability during application". The results are shown in Table 2. Additionally, in Examples 12-18 (not listed in Tables 1, 2, and outside the tables), the PC purity of the hydrogenated soybean lecithin used was 80-90%.

[0147] [Table 1]

[0148]

[0149] Note 1: Phytosterol QI (manufactured by Mitsubishi Chemical Foods Co., Ltd.)

[0150] Note 2: Marine Cholesterol (manufactured by Nippon Suisan Co., Ltd.)

[0151] Note 3: Synthetic pure cerasifera wax JNP-81 (manufactured by Natural Products, Japan)

[0152] Note 4: MULTIWAX W 445 (manufactured by SONNEBORN. LLC)

[0153] Note 5: Rice bran wax SS-1 (manufactured by Bosso Oils & Fats Company)

[0154] Note 6: AEROSIL R972 (smoke-like, non-porous, specific surface area: 110m²) 2 / g, manufactured by Aerosil Corporation, Japan)

[0155] Note 7: KF-6105 (manufactured by Shin-Etsu Chemical Industry Co., Ltd.)

[0156] Note 8: KF-6028P (manufactured by Shin-Etsu Chemical Industry Co., Ltd.)

[0157] Note 9: Cosmol 43V (manufactured by Nissin OILLIO GROUP)

[0158] Note 10: PARLEAM 18 (manufactured by Nippon Oil Company)

[0159] Note 11: CARNATION (manufactured by SONNEBORN. LLC)

[0160] [Table 2]

[0161]

[0162] [Manufacturing Method]

[0163] A: Heat components (1) to (5) to 70°C and mix them evenly.

[0164] B: Heat component (6) to 70°C.

[0165] C: Slowly add B to A and disperse using a dispersion mixer.

[0166] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a vesicle (liposome) dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0167] E: Heat components (7) to (18) to 85°C and mix them evenly.

[0168] F: Slowly add D heated to 85°C to E and disperse evenly.

[0169] G: Fill F into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (lip cosmetic) by cooling.

[0170] [Evaluation Method]

[0171] I. (For solid, water-in-oil cosmetics) Needle penetration load value

[0172] The needle penetration load was measured using a rheometer (manufactured by Rheotech) with a disc adapter (measurement temperature 35°C, range 500 gf, 10 mm φ) and a needle penetration of 2 mm at a speed of 6 cm / min. Three measurements were performed, and the average of the three measurements was used for evaluation according to the following three-level evaluation criteria.

[0173] <Level 3 Evaluation Criteria>

[0174] [Evaluation]: [Pin Penetration Load Value]

[0175] A: 100-300gf

[0176] B: Less than 100gf

[0177] C: Over 300gf

[0178] II. (Stability of solid, water-in-oil cosmetics) Immediately after manufacturing

[0179] The stability immediately after manufacturing is evaluated according to the following three-level criteria. Separation also includes liquid discharge.

[0180] <Level 3 Judgment Criteria>

[0181] [Judgment]: [Evaluation]

[0182] A (Excellent): Completely no separation, excellent texture.

[0183] B (Good): Almost no separation, good texture.

[0184] C (Not allowed): Obvious separation, poor texture.

[0185] III. (Stability over time for solid oil-in-water cosmetics) (50℃ / 1M)

[0186] Regarding stability over time, each sample was stored at a constant temperature of 50°C for one month. From the perspective of separation, it was compared with the sample immediately after manufacturing, and evaluated according to the following four-level judgment criteria. Separation also includes liquid drainage.

[0187] <Level 4 Judgment Criteria>

[0188] [Judgment]: [Evaluation]

[0189] A (Excellent): Completely no separation, excellent texture.

[0190] B (Good): Almost no separation, good texture.

[0191] C (Okay): Slight separation, but good texture.

[0192] D (Not allowed): Obvious separation, poor texture.

[0193] IV. Stability of vesicles (liposomes)

[0194] The average particle size of each sample was measured after being stored at room temperature and constant temperature of 40°C for one month. The formation retention of the vesicle (liposome) composition was evaluated based on the rate of change of average particle size, with the freshly manufactured sample as the baseline. The stability of the vesicle (liposome) composition was determined according to the following four-level judgment criteria.

[0195] (Method for determining average particle size)

[0196] After dissolving 10g of each sample at 80℃, 90g of water at 80℃ was added and mixed for 5 minutes, thereby extracting the vesicle (liposome) composition into the aqueous phase.

[0197] The above extract was filled into a UVette 220-1600nm plastic cuvette (manufactured by Eppendorf), and the peak particle size of the vesicles (liposomes) was measured using a real-time nanoparticle size analyzer, DelsaMax CORE (manufactured by Beckman Coulter). Three measurements were performed on the same sample, and the average of the three measurements was taken as the "average particle size".

[0198] <Level 4 Judgment Criteria>

[0199] [Judgment Criteria]:

[0200] A (Excellent): The rate of change in average particle size is less than ±20%.

[0201] B (Good): The rate of change in average particle size is greater than ±20% and less than ±40%.

[0202] C (Not allowed): The rate of change in average particle size is greater than ±40%.

[0203] V. Occlusion, VI. Usability, VII. Spreadability during application

[0204] Regarding the sealing properties, feel, and spreadability during application, 10 professional cosmetics reviewers evaluated and scored each sample according to the following evaluation criteria. The average score of all reviewers for each sample was calculated and judged according to the following 4-level judgment criteria.

[0205] Regarding occlusion, each sample was applied to the lips, and the occlusion and sealing sensation after spreading were evaluated.

[0206] Regarding the feel of handling, each sample was picked up with fingers to evaluate whether it was easy to pick up and how well it was handled.

[0207] Regarding the goodness of spreadability, each sample was applied to the lips, and the uniformity of spreadability was evaluated.

[0208] <Absolute Evaluation Benchmark>

[0209] [Rating]: [Evaluation]

[0210] 5 points: Excellent

[0211] 4 points: Good

[0212] 3 points: Average

[0213] 2 points: Poor

[0214] 1 point: Very poor

[0215] <Level 4 Judgment Criteria>

[0216] [Judgment]: [Average score]

[0217] A (Excellent): 4.0 points or above

[0218] B (Good): 3.5 points or higher but less than 4.0 points

[0219] C (Acceptable): 2.5 points or higher but less than 3.5 points

[0220] D (Poor): Less than 2.5 points

[0221] As shown in Table 1, the solid oil-in-water cosmetics (lip cosmetics) of Examples 1 to 11 all obtained good evaluation results in the evaluation items of "stability of solid oil-in-water cosmetics immediately after manufacturing", "stability of solid oil-in-water cosmetics over time (50℃ / 1M)" and "stability of vesicles (liposomes)".

[0222] Furthermore, as shown in Table 2, the solid oil-in-water cosmetics (lip cosmetics) of Examples 1, 2, 4 to 10, in particular, achieved good results in terms of occlusion, feel, and spreadability during application.

[0223] On the other hand, the "stability immediately after manufacturing" and "stability of vesicles (lip bodies)" of the solid oil-in-water cosmetic (lip cosmetic) of Comparative Example 1, which does not contain ingredient (C), are not good. Regarding the "needle penetration load value," due to leakage, the cosmetic itself cannot maintain a solid state, so it cannot be evaluated. Furthermore, regarding the "stability over time (50°C / 1M)," since the stability immediately after manufacturing is unsatisfactory, it cannot be evaluated either. The occlusive properties of the solid oil-in-water cosmetic (lip cosmetic) of Comparative Example 1 are not good; as mentioned above, it cannot maintain a solid state, therefore, the "feel and spreadability during application" cannot be evaluated.

[0224] Example 12: Solid oil-in-water cosmetic (balm)

[0225] (Ingredients) (mass%)

[0226] 1. Hydrogenated soybean lecithin 0.5

[0227] 2. Phytosterols (Note 1: 0.1%)

[0228] 3,1,3-Butanediol 2

[0229] 4. Glycerin 2

[0230] 5. Purified water 10

[0231] 6. Paraffin wax, note 3.5

[0232] 7. Microcrystalline wax injection 4 5

[0233] 8. Dimethylsilylated silica (Note 6.2)

[0234] 9. Laurethyl polyglycerol-3-dimethylsiloxane (Note 7.5)

[0235] 10. Polyglycerol-2-triisostearate (Note 9.5)

[0236] 11. Polyglycerol-2-diisostearate (Note 12.5)

[0237] 12. Hydrogenated polyisobutylene (Note: 10 10)

[0238] 13. Mineral oil injection 11 20

[0239] 14. Diisostearyl malate 10

[0240] 15. Triglyceride (balance)

[0241] 16. Polydimethylsiloxane (kinematic viscosity of 10 mmHg at 25°C) 2 / s) 5

[0242] 17. Phenoxyethanol 0.5

[0243] 18.BHT 0.1

[0244] 19. Tocopherol 0.1

[0245] 20. Ceramide NG 0.1

[0246] 21. Ceramide NP 0.1

[0247] 22. Spices 0.1

[0248] Note 12: Cosmol 42V (manufactured by Nissin OILLIO GROUP)

[0249] [Manufacturing Method]

[0250] A: Heat components (1) to (4) to 70°C and mix them evenly.

[0251] B: Heat component (5) to 70°C.

[0252] C: Slowly add B to A and disperse using a dispersion mixer.

[0253] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0254] E: Heat components (6) to (22) to 85°C and mix them evenly.

[0255] F: Slowly add D heated to 85°C to E and disperse evenly.

[0256] G: Fill F into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (balm) by cooling.

[0257] The solid oil-in-water cosmetic (balm) of Example 12 exhibited excellent stability immediately after manufacturing, stability over time, and stability of vesicles (liposomes). Furthermore, it also showed good results in terms of occlusion, feel, and spreadability during application. In addition, the needle penetration load was rated as A.

[0258] Example 13: Solid oil-in-water cosmetic (lipstick)

[0259] (Ingredients) (mass%)

[0260] 1. Hydrogenated soybean lecithin 0.5

[0261] 2. Phytosterols (Note 1: 0.1%)

[0262] 3,1,3-Butanediol 2

[0263] 4. Glycerin 2

[0264] 5. Purified water 10

[0265] 6. Paraffin wax, note 3.10

[0266] 7. Microcrystalline wax injection 4 10

[0267] 8. Candelilla wax, note 13 1

[0268] 9. Carnauba wax 1

[0269] 10. Dimethylsilylated silica (Note 6.2)

[0270] 11. Palmitic acid dextrin ester (Note 14 1)

[0271] 12. Laurethyl polyglycerol-3-dimethylsiloxane (Note 7.5)

[0272] 13. Polyglycerol-2-triisostearate (Note 9.5)

[0273] 14. Hydrogenated polyisobutylene (Note 15 10)

[0274] 15. Isododecane 5

[0275] 16. Diisostearyl malate 10

[0276] 17. Balance of triglycerides (ethylhexanoate)

[0277] 18. Polydimethylsiloxane (kinematic viscosity of 100 mmHg at 25°C) 2 / s) 2

[0278] 19. Diphenyl polydimethylsiloxane 5

[0279] 20. Phenoxyethanol 0.5

[0280] 21.BHT 0.1

[0281] 22. Spices 0.1

[0282] 23. Titanium oxide 3

[0283] 24. Iron oxide 1

[0284] 25. Yellow 4 2

[0285] 26. Red 202 1

[0286] Note 13: Refined candelilla wax SR-3 (manufactured by Natural Products, Japan)

[0287] Note 14: Rheopearl TL2 (manufactured by Chiba Flour Milling Co., Ltd.)

[0288] Note 15: PARLEAM 24 (manufactured by Nippon Oil Company)

[0289] [Manufacturing Method]

[0290] A: Heat components (1) to (4) to 70°C and mix them evenly.

[0291] B: Heat component (5) to 70°C.

[0292] C: Slowly add B to A and disperse using a dispersion mixer.

[0293] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0294] E: Heat components (6) to (26) to 85°C and mix them evenly.

[0295] F: Slowly add D heated to 85°C to E and disperse evenly.

[0296] G: Fill F into a rod-shaped container at 80°C, and obtain a solid oil-in-water cosmetic (lipstick) by cooling.

[0297] The solid oil-in-water cosmetic (lipstick) of Example 13 exhibited excellent performance in terms of "stability immediately after manufacturing", "stability over time", and "stability of vesicles (liposomes)". Furthermore, it also showed good results in terms of occlusion, feel, and spreadability during application. Additionally, the needle penetration load value was rated as C.

[0298] Example 14: Solid oil-in-water cosmetic (moisturizing cream)

[0299] (Ingredients) (mass%)

[0300] 1. Hydrogenated soybean lecithin 0.5

[0301] 2. Cholesterol (Note 1: 0.1)

[0302] 3,1,3-Butanediol 2

[0303] 4. Glycerin 2

[0304] 5. Dipropylene glycol 1

[0305] 6. Purified water 10

[0306] 7. Nicotinamide 4

[0307] 8. Tranexamic acid 3

[0308] 9. Purified water 20

[0309] 10. Paraffin wax, note 3.5

[0310] 11. Microcrystalline wax injection 4 5

[0311] 12. Rice bran wax injection 5 1

[0312] 13. Dimethylsilylated silica (Note 6.2)

[0313] 14. Laurethyl polyglycerol-3-dimethylsiloxane (Note 7.5)

[0314] 15. Polyglycerol-2-triisostearate (Note 9.5)

[0315] 16. Hydrogenated polyisobutylene (Note 10.4)

[0316] 17. Hydrogenated polyisobutylene (Note 16)

[0317] 18. Mineral oil injection 11 10

[0318] 19. Diisostearyl malate 5

[0319] 20. Triglyceride (balance)

[0320] 21. Polydimethylsiloxane (kinematic viscosity of 10 mmHg at 25°C) 2 / s) 5

[0321] 22. Phenoxyethanol 0.5

[0322] 23.BHT 0.1

[0323] 24. Spices 0.1

[0324] Note 16: PARLEAM 46 (manufactured by Nippon Oil Company)

[0325] [Manufacturing Method]

[0326] A: Heat components (1) to (5) to 70°C and mix them evenly.

[0327] B: Heat component (6) to 70°C.

[0328] C: Slowly add B to A and disperse using a dispersion mixer.

[0329] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0330] E: Mix components (7) to (9) evenly at room temperature, then add them to D and mix.

[0331] F: Heat components (10) to (24) to 85°C and mix them evenly.

[0332] G: Slowly add E heated to 85°C to F and disperse evenly.

[0333] H: Fill G into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (moisturizing cream) by cooling.

[0334] The solid oil-in-water cosmetic (moisturizing cream) of Example 14 exhibited excellent stability immediately after manufacturing, stability over time, and stability of vesicles (liposomes). Furthermore, it also showed good results in terms of occlusion, feel, and spreadability during application. In addition, the needle penetration load was rated as A.

[0335] Example 15: Solid oil-in-water cosmetic (cream)

[0336] (Ingredients) (mass%)

[0337] 1. Hydrogenated soybean lecithin 0.5

[0338] 2. Cholesterol 0.1g

[0339] 3,1,3-Butanediol 2

[0340] 4. Glycerin 2

[0341] 5. Dipropylene glycol 1

[0342] 6. Purified water 10

[0343] 7.L-Ascorbic acid 2-glucoside 3

[0344] 8. Sodium monohydrogen phosphate 0.1

[0345] 9. Sodium dihydrogen phosphate 0.1

[0346] 10. Sodium hydroxide 0.3

[0347] 11. Purified water 30

[0348] 12. Paraffin wax, note 3.2

[0349] 13. Microcrystalline wax injection 4 2

[0350] 14. Carnauba wax 1

[0351] 15. Dimethylsilylated silica (Note 6.2)

[0352] 16. Distearate dimethylammonium lithium montmorillonite (Note 17 1)

[0353] 17. Laureth-polyglycerol-3-dimethylsiloxane (Note 7.5)

[0354] 18. Polyglycerol-2-triisostearate (Note 9.5)

[0355] 19. Hydrogenated polyisobutylene (Note 10.5)

[0356] 20. Mineral oil injection 11 10

[0357] 21. Beef tallow 1

[0358] 22. Diisostearyl malate 5

[0359] 23. Triglyceride (balance)

[0360] 24. Polydimethylsiloxane (kinematic viscosity of 6 mmHg at 25°C) 2 / s) 5

[0361] 25. Polydimethylsiloxane (kinematic viscosity of 10 mmHg at 25°C) 2 / s) 3

[0362] 26. Polydimethylsiloxane (kinematic viscosity of 100 mmHg at 25°C) 2 / s) 2

[0363] 27. Phenoxyethanol 0.5

[0364] 28.BHT 0.1

[0365] 29. Spices 0.1

[0366] Note 17: BENTONE 38V (manufactured by Elementis)

[0367] [Manufacturing Method]

[0368] A: Heat components (1) to (5) to 70°C and mix them evenly.

[0369] B: Heat component (6) to 70°C.

[0370] C: Slowly add B to A and disperse using a dispersion mixer.

[0371] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0372] E: Mix components (7) to (11) evenly at room temperature, then add them to D and mix.

[0373] F: Heat components (12) to (29) to 85°C and mix them evenly.

[0374] G: Slowly add E heated to 85°C to F and disperse evenly.

[0375] H: Fill G into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (cream) by cooling.

[0376] The solid oil-in-water cosmetic (cream) of Example 15 exhibited excellent stability immediately after manufacturing, stability over time, and stability of vesicles (liposomes). Furthermore, it also showed good results in terms of occlusion, feel, and spreadability during application. Additionally, the needle penetration load was rated as B.

[0377] Example 16: Solid oil-in-water cosmetic (balm)

[0378] (Ingredients) (mass%)

[0379] 1. Hydrogenated soybean lecithin 0.5

[0380] 2. Phytosterols (Note 2: 0.1%)

[0381] 3,1,3-Butanediol 2

[0382] 4. Glycerin 2

[0383] 5. Purified water 10

[0384] 6. Paraffin wax, note 3.5

[0385] 7. Microcrystalline wax injection 4 5

[0386] 8. Dimethylsilylated silica (Note 6.2)

[0387] 9. Distearate dimethylammonium lithium montmorillonite (Note 17.1)

[0388] 10. Laureth-polyglycerol-3-dimethylsiloxane (Note 7.5)

[0389] 11. Polyglycerol-2-triisostearate (Note 9.5)

[0390] 12. Polyglycerol-2-diisostearate (Note 12.5)

[0391] 13. Hydrogenated polyisobutylene (Note: 10 10)

[0392] 14. Mineral oil injection 11 20

[0393] 15. Diisostearyl malate 10

[0394] 16. Triglyceride (balance)

[0395] 17. Polydimethylsiloxane (kinematic viscosity of 10 mmHg at 25°C) 2 / s) 5

[0396] 18. Phenoxyethanol 0.5

[0397] 19.BHT 0.1

[0398] 20. Tocopherol 0.1

[0399] 21. Ceramide NG 0.1

[0400] 22. Ceramide NP 0.1

[0401] 23. Spices 0.1

[0402] 24. Titanium oxide 2

[0403] 25. Iron oxide 2

[0404] 26. Yellow 4 1

[0405] 27. Red 202 1

[0406] [Manufacturing Method]

[0407] A: Heat components (1) to (4) to 70°C and mix them evenly.

[0408] B: Heat component (5) to 70°C.

[0409] C: Slowly add B to A and disperse using a dispersion mixer.

[0410] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0411] E: Heat components (6) to (27) to 85°C and mix them evenly.

[0412] F: Slowly add D heated to 85°C to E and disperse evenly.

[0413] G: Fill F into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (balm) by cooling.

[0414] The solid oil-in-water cosmetic (balm) of Example 16 exhibited excellent stability immediately after manufacturing, stability over time, and stability of vesicles (liposomes). Furthermore, it also showed good results in terms of occlusion, feel, and spreadability during application. In addition, the needle penetration load was rated as A.

[0415] Example 17: Solid oil-in-water cosmetic (moisturizing cream)

[0416] (Ingredients) (mass%)

[0417] 1. Hydrogenated soybean lecithin 0.5

[0418] 2. Cholesterol (Note 1: 0.1)

[0419] 3,1,3-Butanediol 2

[0420] 4. Glycerin 2

[0421] 5. Dipropylene glycol 1

[0422] 6. Purified water 10

[0423] 7. Nicotinamide 4

[0424] 8. Tranexamic acid 3

[0425] 9. Purified water 20

[0426] 10. Paraffin wax, note 3.5

[0427] 11. Microcrystalline wax injection 4 5

[0428] 12. Rice bran wax injection 5 1

[0429] 13. Dimethylsilylated silica (Note 6.2)

[0430] 14. Distearate dimethylammonium lithium montmorillonite (Note 17.1)

[0431] 15. Laurethyl polyglycerol-3-dimethylsiloxane (Note 7.5)

[0432] 16. Polyglycerol-2-triisostearate (Note 9.5)

[0433] 17. Hydrogenated polyisobutylene (Note 10.5)

[0434] 18. Mineral oil injection 11 10

[0435] 19. Diisostearyl malate 5

[0436] 20. Triglyceride (balance)

[0437] 21. Polydimethylsiloxane (kinematic viscosity of 100 mmHg at 25°C) 2 / s) 5

[0438] 22. Phenoxyethanol 0.5

[0439] 23.BHT 0.1

[0440] 24. Spices 0.1

[0441] 25. Titanium oxide 1

[0442] [Manufacturing Method]

[0443] A: Heat components (1) to (5) to 70°C and mix them evenly.

[0444] B: Heat component (6) to 70°C.

[0445] C: Slowly add B to A and disperse using a dispersion mixer.

[0446] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0447] E: Mix components (7) to (9) evenly at room temperature, then add them to D and mix.

[0448] F: Heat components (10) to (25) to 85°C and mix them evenly.

[0449] G: Slowly add E heated to 85°C to F and disperse evenly.

[0450] H: Fill G into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (moisturizing cream) by cooling.

[0451] The solid oil-in-water cosmetic (moisturizing cream) of Example 17 exhibited excellent stability immediately after manufacturing, stability over time, and stability of vesicles (liposomes). Furthermore, it also showed good results in terms of occlusion, feel, and spreadability during application. In addition, the needle penetration load was rated as A.

[0452] Example 18: Solid oil-in-water cosmetic (moisturizing cream)

[0453] (Ingredients) (mass%)

[0454] 1. Hydrogenated soybean lecithin 2

[0455] 2. Phytosterols (Note 1: 0.4%)

[0456] 3,1,3-Butanediol 4

[0457] 4. Glycerin

[0458] 5. Purified water 60

[0459] 6. Paraffin wax, note 3.3

[0460] 7. Microcrystalline wax injection 4 3

[0461] 8. Dimethylsilylated silica (Note 6.1)

[0462] 9. Laurethyl polyglycerol-3-dimethylsiloxane (Note 7)

[0463] 10. Polyglycerol-2-triisostearate (Note 9)

[0464] 11. Polyglycerol-2-diisostearate (Note 12 1)

[0465] 12. Hydrogenated polyisobutylene (Note 10)

[0466] 13. Hydrogenated polyisobutylene (Note 15)

[0467] 14. Mineral oil injection 11 3

[0468] 15. Diisostearyl malate 2

[0469] 16. Triglyceride (balance)

[0470] 17. Polydimethylsiloxane (kinematic viscosity of 100 mmHg at 25°C) 2 / s) 3

[0471] 18. Phenoxyethanol 0.5

[0472] 19.BHT 0.1

[0473] 20. Tocopherol 0.1

[0474] 21. Ceramide NG 0.1

[0475] 22. Ceramide NP 0.1

[0476] 23. Spices 0.1

[0477] [Manufacturing Method]

[0478] A: Heat components (1) to (4) to 70°C and mix them evenly.

[0479] B: Heat component (5) to 70°C.

[0480] C: Slowly add B to A and disperse using a dispersion mixer.

[0481] D: C was cooled to room temperature and subjected to high-pressure treatment using a microfluidic homogenizer to prepare a liposome dispersion. Furthermore, it was confirmed that the liposome composition prepared here consists of multilayer vesicles with a multilayer bilayer membrane structure.

[0482] E: Heat components (6) to (23) to 85°C and mix them evenly.

[0483] F: Slowly add D heated to 85°C to E and disperse evenly.

[0484] G: Fill F into a resin wide-mouth bottle container (40H×56W×56L, MCW-50, manufactured by Takemoto Container Co., Ltd.) at 80°C, and obtain a solid oil-in-water cosmetic (moisturizing cream) by cooling.

[0485] The solid oil-in-water cosmetic (moisturizing cream) of Example 18 exhibited excellent stability immediately after manufacturing, stability over time, and stability of vesicles (liposomes). Furthermore, it also showed good results in terms of feel and spreadability during application. Additionally, the needle penetration load was rated as A.

Claims

1. A solid, water-in-oil cosmetic, comprising at least: Component (A) Vesicle composition, Ingredient (B) Oily gelling agent, and Component (C) is an lipophilic surfactant.

2. The solid oil-in-water cosmetic according to claim 1, wherein component (A) is a liposome composition.

3. The solid oil-in-water cosmetic according to claim 2, Component (A) is a liposome composition containing at least: Component (a1) Phospholipids, Component (a2) Sterols, and Component (a3) ​​Polyol.

4. The solid oil-in-water cosmetic according to claim 1 or 2, wherein ingredient (B) contains at least ingredient (b1) wax.

5. The solid oil-in-water cosmetic according to claim 4, wherein the content of component (b1) is 1 to 30% by mass relative to the total amount of the cosmetic.

6. The solid oil-in-water cosmetic according to claim 4, wherein component (B) contains an oily gelling agent other than component (b1) wax and component (b2) wax.

7. The solid oil-in-water cosmetic according to claim 6, wherein the component (b2) is at least one selected from the group consisting of dextrin fatty acid ester, sucrose fatty acid ester, inulin fatty acid ester, 12-hydroxystearic acid, metal soap, organic modified clay mineral, amino acid gelling agent and inorganic powder.

8. The solid oil-in-water cosmetic according to claim 7, wherein component (b2) is an inorganic powder.

9. The solid water-in-oil cosmetic according to claim 1 or 2, wherein the solid water-in-oil cosmetic further contains component (D) fatty acid glycerides (wherein, Exclude the aforementioned component (C)).

10. The solid water-in-oil cosmetic according to claim 1 or 2, wherein the water content is less than 80% by mass relative to the total amount of the cosmetic.

11. The solid oil-in-water cosmetic according to claim 1 or 2, wherein the needle penetration load value of the cosmetic is 50 to 500 gf.

12. The solid oil-in-water cosmetic according to claim 1 or 2, wherein the cosmetic is a skin care cosmetic.

13. The solid oil-in-water cosmetic according to claim 1 or 2, wherein the cosmetic is a lip cosmetic.

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