A scalp-protecting composition

Abstract

The present invention relates to a scalp protection composition and methods of making and using the same.

Description

Technical Field

[0001] This disclosure relates to a scalp protection composition, and more particularly to a scalp protection composition that can be used prior to hair dyeing and / or perming to protect the scalp from damage or discomfort caused by hair dyes and perming agents. Background Technology

[0002] Changing hair color and / or shape has become common among people of all ages and genders. However, most commercially available hair dyes and perms are highly alkaline. When these products come into contact with the user's scalp, they can cause damage or discomfort, leading to irritation, redness, itching, etc. Therefore, to protect the scalp from damage or discomfort under harsh conditions, a scalp protectant can be applied to the scalp before applying hair dyes and perms.

[0003] Currently, alkali-resistant dimethyl silicone oil or mineral oil contained in scalp protectants can isolate the scalp from hair dyes and perms, thus protecting it. However, these compounds do not provide complete protection and relief from scalp discomfort, and may even burden the scalp. Some existing technologies propose adding biomolecules to reduce scalp irritation; for example, CN101289686 teaches the use of collagen, and KR101277530B1 suggests adding amino acids. However, biomolecules have poor stability in compositions and are relatively expensive.

[0004] Therefore, there is still a need in the field to develop a scalp protection composition that offers excellent protection and is cost-effective. Summary of the Invention

[0005] The purpose of this invention is to provide a scalp protection composition that solves one or more problems of the prior art and has excellent protective effect on the scalp.

[0006] The object of the present invention is achieved by a scalp protection composition comprising: (a) A nanoemulsion prepared from a mixture of the following components: (a1) 10.0-20.0% by weight of myristyl myristate, (a2) 5.0-10.0% by weight of cetearyl alcohol polyether-12, (a3) 1.0-5.0% by weight of glyceryl stearate, (a4) 0.01-1.0% by weight of cetearyl alcohol, (a5) 0.35-0.75% by weight of cetyl palmitate, (a6) 0.7-1.5% by weight of cetearyl alcohol polyether-20, (a7) 0.01-1.0% by weight of potassium cetyl phosphate and / or sodium cetyl phosphate, (a8) 0-0.5% by weight of preservatives, such as sodium benzoate. (a9) 0.05-0.5% by weight of lactic acid or its salt, (a10) 10.0-30.0% by weight of glycerol, and (a11) 40.0-60.0% by weight of water, The respective weight percentages of (a1) to (a11) are based on the total weight of (a1) to (a11); and (b) One or more thickeners.

[0007] The present invention also provides a method for preparing the scalp protection composition, comprising: (i) The nanoemulsion is prepared from components (a1) to (a11) by high shear stirring, phase transition temperature (PIT) method or phase transition composition (PIC) method, preferably by phase transition temperature (PIT) method; (ii) The nanoemulsion is mixed with one or more thickeners and water by stirring to form a homogeneous mixture.

[0008] The present invention also relates to the use of the scalp protection composition in protecting the scalp before hair dyeing or perming. Detailed Implementation

[0009] Those skilled in the art will understand that this discussion is merely a description of exemplary embodiments and is not intended to limit the broader aspects of the invention. Each aspect thus described may be combined with one or more other aspects unless explicitly stated otherwise. In particular, any feature indicated as preferred or advantageous may be combined with one or more other features indicated as preferred or advantageous.

[0010] Unless otherwise specified, the terms used in the context of this invention shall be interpreted in accordance with the following definitions.

[0011] Unless otherwise specified, the terms “a,” “an,” and “the” used herein include both singular and plural references.

[0012] The terms “comprises” and “including” as used herein are synonymous with “contains” and are inclusive or open-ended, not excluding additional unlisted members, elements or process steps.

[0013] The term “composed of” as used herein is closed-ended, excluding any additional, unlisted, intentionally added members, elements, or process steps.

[0014] The terms “at least one” or “one or more” used in this article to define components refer to the type of component, not the absolute number of molecules.

[0015] In this document, the terms “about”, “approximately”, etc., used with numerical values ​​refer to the value ±10%, preferably ±5%. All numerical values ​​in this document should be interpreted as being modified by the term “about”.

[0016] Unless otherwise specified, the enumeration of numerical endpoints includes all numbers and fractions within the corresponding range, as well as the enumerated endpoints.

[0017] Unless otherwise defined, all terms used in this invention (including technical and scientific terms) have the meanings commonly understood by one of ordinary skill in the art to which this invention pertains.

[0018] The components will be described in detail below.

[0019] Component (a) The nanoemulsion of component (a) is a necessary and important component of the composition and plays an important role in scalp protection.

[0020] As used herein, the term "nanoemulsion" has its common meaning in the art, referring to a stable dispersion of nanoscale droplets of one fluid in another fluid. In this invention, the nanoemulsion is an oil-in-water nanoemulsion.

[0021] The nanoemulsions used in this invention are formed and prepared from a mixture of the following components: (a1) 10.0-20.0% by weight, preferably 12.0-18.0% by weight of myristoyl myristate. For example, 12% by weight, 14% by weight, 16% by weight, 18% by weight, or any range between the listed values; (a2) 5.0-10.0% by weight, preferably 7.5-10.0% by weight of cetearyl alcohol polyether-12. For example, 6% by weight, 7% by weight, 8% by weight, 9% by weight, or any range between the listed values ​​for cetearyl alcohol polyether-12; (a3) 1.0-5.0% by weight, preferably 1.1-4.9% by weight of glyceryl stearate. For example, glyceryl stearate in the range of 2%, 3%, 4%, or any range between the listed values; (a4) 0.01-1.0% by weight, preferably 0.05-0.9% by weight of cetearyl alcohol, For example, 0.2% by weight, 0.4% by weight, 0.6% by weight, 0.8% by weight, or any range between the listed values ​​for cetearyl alcohol; (a5) 0.35-0.75% by weight, preferably 0.38-0.70% by weight of cetyl palmitate. For example, 0.4 wt%, 0.5 wt%, 0.6 wt%, 0.7 wt%, or any range between the listed values ​​for cetyl palmitate; (a6) 0.7-1.5% by weight, preferably 0.8-1.4% by weight of cetearyl alcohol polyether-20, For example, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.2 wt%, 1.4 wt%, or any range between the listed values ​​for cetearyl alcohol polyether-20; (a7) 0.01-1.0% by weight, preferably 0.02-0.8% by weight of potassium cetyl phosphate and / or sodium cetyl phosphate, For example, 0.1 wt%, 0.2 wt%, 0.4 wt%, 0.6 wt%, 0.8 wt%, or any range between the listed values ​​for potassium cetyl phosphate and / or sodium cetyl phosphate; (a8) 0-0.5% by weight, preferably 0.1-0.4% by weight, of a preservative, such as sodium benzoate. For example, sodium benzoate in the range of 0.1 wt%, 0.2 wt%, 0.3 wt%, 0.4 wt%, or any range between the listed values; (a9) 0.05-0.5% by weight, preferably 0.1-0.5% by weight of lactic acid or its salt, For example, 0.2% by weight, 0.3% by weight, 0.4% by weight, or any range between the listed values ​​for lactic acid or its salts; (a10) 10.0-30.0% by weight, preferably 15.0-25.0% by weight of glycerol. For example, glycerin in 12 wt%, 14 wt%, 16 wt%, 18 wt%, 20 wt%, 22 wt%, 24 wt%, 26 wt%, 28 wt%, or any range between the listed values; (a11) 40.0-60.0% by weight, preferably 45.0-55.0% by weight of water. For example, 42% by weight, 44% by weight, 46% by weight, 48% by weight, 50% by weight, 52% by weight, 54% by weight, 56% by weight, 58% by weight, or any range of the listed values ​​for water.

[0022] Each weight percentage here is based on the total weight from (a1) to (a11).

[0023] The nanoemulsions used in this invention can be obtained by methods known in the art, such as high-shear stirring, phase transition temperature (PIT) method, or phase transition composition (PIC) method. Although there are no particular limitations on the preparation method of the nanoemulsion, the phase transition temperature (PIT) method is preferred from an energy-saving perspective.

[0024] For the phase transition temperature (PIT) method, all components (a1) to (a11) listed above can be mixed together at room temperature to form a homogeneous mixture, and then the mixture can be heated to above 75°C but preferably below 100°C, such as 77°C, 79°C, 80°C, 82°C, 84°C, 86°C, 88°C, or 90°C; alternatively, each component can be heated separately to the above temperatures and then mixed together homogeneously; then, the heated mixture can be rapidly cooled to room temperature, for example by an ice bath, and all the above steps are preferably carried out under stirring. Through the phase transition temperature method, the droplets in the nanoemulsion have an orthorhombic lateral packing structure.

[0025] The term "room temperature" as used in this article refers to a temperature of 25±2℃.

[0026] There are no particular restrictions on the order in which components (a1) to (a11) are added; they can be mixed together, one by one, or in pairs, etc.

[0027] Preferably, the droplets in the nanoemulsion have an average particle size of 20-500 nm, more preferably 20-300 nm, such as 20-150 nm, 40 nm, 60 nm, 80 nm, 100 nm, 120 nm, 140 nm, 160 nm, 180 nm, 200 nm, 220 nm, 240 nm, 260 nm, 280 nm, 300 nm, 320 nm, 340 nm, 360 nm, 380 nm, 400 nm, 420 nm, 440 nm, 460 nm, 480 nm, or any range between the values ​​listed above. This particle size is determined using a Malvern Nano ZS90 by dynamic light scattering.

[0028] To obtain a highly stable nanoemulsion at room temperature, it is preferable that the zeta potential of the nanoemulsion is greater than 20 mV at room temperature, more preferably greater than 30 mV at room temperature, for example 20-50 mV at room temperature, as determined using a Malvern Nano ZS90.

[0029] The nanoemulsion may be present in the scalp protection composition at a concentration of 4-20 wt%, more preferably 5-15 wt%, for example 4 wt%, 5 wt%, 6 wt%, 7 wt%, 8 wt%, 9 wt%, 10 wt%, 12 wt%, 14 wt%, 16 wt%, 18 wt%, 20 wt%, or any range between the values ​​listed above, based on the total weight of the scalp protection composition.

[0030] Component (b) To achieve the appropriate viscosity, the scalp protection composition may contain one or more thickeners.

[0031] The thickeners used in this invention can be polymeric thickeners, including nonionic and anionic thickeners, or mixtures thereof. Suitable nonionic thickeners include polyacrylamide polymers, crosslinked poly(N-vinylpyrrolidone), polysaccharides, natural or synthetic gums or polysaccharides, polyvinylpyrrolidone, and polyvinyl alcohol. Suitable anionic thickeners include acrylic / ethyl acrylate copolymers, carboxyvinyl polymers, and crosslinked copolymers of alkyl vinyl ethers and maleic anhydride.

[0032] The thickeners that can be used in this invention can also be polysaccharides, including cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylic acid, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof; natural gums, such as gum arabic, agar, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimethylammonium chloride, hydroxypropyl chitosan, hydroxypropyl guar gum, ebony gum, alginate, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

[0033] There is no particular limitation on the amount of thickener used, and it can be adjusted according to the desired form of the scalp protection composition. For example, the amount of thickener used can be 0.01-5% by weight, preferably 0.1-4% by weight, more preferably 0.15-2% by weight, such as 0.05% by weight, 0.1% by weight, 0.15% by weight, 0.2% by weight, 0.25% by weight, 0.3% by weight, 0.35% by weight, 0.4% by weight, 0.45% by weight, or any range between two of the listed values, based on the total weight of the scalp protection composition.

[0034] In one embodiment, 0.05-1% by weight of a thickener may be added to obtain a composition with a viscosity of less than 4000 mPa·s at room temperature, as measured using a Brookfield RVDV II+ viscometer at 20 rpm and rotor No. 4.

[0035] Other components In addition to components (a) and (b) above, the scalp protection composition may also contain one or more other conventional additives, such as panthenol; allantoin; pH adjusters, such as alkali metal hydroxides (e.g., NaOH, KOH), or acids such as lactic acid; chelating agents such as EDTA Na2; preservatives; etc.

[0036] Panthenol and / or allantoin can be used in conjunction with the above-mentioned nanoemulsions for optimal scalp protection, particularly significantly reducing scalp itching and burning during or after hair dyeing or perming.

[0037] If present, a suitable amount of panthenol in the scalp protection composition is 0.05-5% by weight, preferably 0.05-3% by weight, more preferably 0.1-2.5% by weight, for example 0.1% by weight, 0.3% by weight, 0.6% by weight, 0.8% by weight, 1.0% by weight, 1.2% by weight, 1.4% by weight, 1.6% by weight, 1.8% by weight, 2.0% by weight, 2.4% by weight, 2.8% by weight, 3.0% by weight, 3.4% by weight, 3.8% by weight, 4.0% by weight, 4.4% by weight, 4.8% by weight, or any range between two of the listed values, based on the total weight of the scalp protection composition.

[0038] If present, a suitable amount of allantoin in the scalp protection composition is 0.05-0.5% by weight, preferably 0.08-0.45% by weight, for example 0.1% by weight, 0.15% by weight, 0.2% by weight, 0.25% by weight, 0.3% by weight, 0.35% by weight, 0.4% by weight, 0.45% by weight, or any range between two of the listed values, based on the total weight of the scalp protection composition.

[0039] Preferably, the pH range of the scalp protection composition is 4-8, more preferably 5-7.5.

[0040] In addition to all the components mentioned above, the remaining portion of the scalp protection composition may be water. In other words, the scalp protection composition of the present invention is water-based, preferably with a water content of not less than 75% by weight, more preferably 80-97% by weight, and even more preferably 85-96% by weight, based on the total weight of the scalp protection composition.

[0041] Method for preparing scalp protection composition In another aspect of the invention, a method for preparing a scalp protection composition is provided, comprising: (i) The nanoemulsion is prepared from the above components (a1) to (a11) by means of high shear stirring, phase transition temperature (PIT) method or phase transition composition (PIC) method, preferably by means of phase transition temperature (PIT) method; (ii) The nanoemulsion is mixed with one or more thickeners and water by stirring to form a homogeneous mixture.

[0042] Step (ii) can be performed at room temperature.

[0043] Example The present invention will now be described through the following embodiments. These embodiments are intended to help those skilled in the art better understand and implement the invention. The scope of the invention is not limited by the embodiments, but is defined by the appended claims. Unless otherwise stated, all parts and percentages are based on weight. In all embodiments, the same names refer to the same substances.

[0044] Nanoemulsion Nanoemulsions 1-5 were prepared according to the components and amounts listed in Table 1. All amounts in Table 1 are based on the total weight of the nanoemulsions.

[0045] Taking nanoemulsion 1 as an example, the preparation method is as follows: (1) Mix (a1) to (a6) together and heat to 80°C with stirring to form mixture 1; (2) Mix (a7) to (a10) and heat to 80°C with stirring to form mixture 2; (3) Mixtures 1 and 2 are mixed together with stirring at 80°C to form mixture 3; and (4) Mixture 3 was rapidly cooled to room temperature in an ice bath with stirring to form a uniform nanoemulsion.

[0046] Nanoemulsions 2-5 were prepared using the same method, the difference being the use of the components and amounts listed in Table 1.

[0047] Table 1: Nanoemulsions 1-5

[0048] Scalp protection composition 1 to 4 The components listed in Table 2 were mixed at room temperature to obtain scalp protection compositions 1 to 4.

[0049] Table 2

[0050] # Carbomer 980 is a polyacrylic acid thickener.

[0051] Euxyl PE 9010 is a mixture of phenoxyethanol and ethylhexylglycerin, used as a preservative, derived from Schuelke.

[0052] Scalp protection effect test In the half-head model test, one composition was evenly applied to one side of the head to completely cover the scalp, while another composition was evenly applied to the other side of the head to completely cover the scalp. The amount of composition applied to each half-head was approximately 3-4 g. A routine hair dyeing process was then performed, and the scalp response of the model was assessed using the 3S (Scalp Symptom Scale) questionnaire. Five symptoms (itching, stinging, tightness, pain, and burning) were rated according to individual tolerance. The rating scale ranged from 0 to 4, with higher scores indicating more severe symptoms.

[0053] Half-head model tests were conducted using Composition 1 (BM) and Composition 3 (of the present invention) (Test 1, see Table 3), Composition 2 (Comparative Example) and Composition 3 (of the present invention) (Test 2, see Table 4), and Composition 3 (of the present invention) and Composition 4 (of the present invention) (Test 3, see Table 5). The same hair dye was used in one half-head test, but different hair dyes were used in different tests. The test results are shown in Tables 3 to 5.

[0054] Table 3

[0055] As can be seen from the results in Table 3, compared with the baseline without nanoemulsion, the composition 3 of the present invention can significantly reduce discomfort (including itching, tightness and burning sensation) during and after hair dyeing.

[0056] Table 4

[0057] As can be seen from the results in Table 4, compared with composition 2 containing 3% nanoemulsion, composition 3 of the present invention containing 5% nanoemulsion can further reduce discomfort (including itching, stinging, tightness, pain and burning sensation) during and after hair dyeing.

[0058] Table 5

[0059] As can be seen from the results in Table 5, the two compositions containing different thickeners according to the present invention achieved comparable performance in terms of scalp protection.

[0060] The results of the half-head model tests 1 through 3 cannot be directly compared because the hair dyes used in tests 1 through 3 are different. However, since the same hair dye was used in each test, the results of each test can be directly compared.

[0061] Although some preferred embodiments have been described, many modifications and variations can be made to them in accordance with the above teachings. Therefore, it should be understood that the invention can be practiced in ways different from those specifically described without departing from the scope of the appended claims.

Claims

1. A scalp protection composition comprising: (a) A nanoemulsion prepared from a mixture of the following components: (a1) 10.0-20.0% by weight of myristyl myristate, (a2) 5.0-10.0% by weight of cetearyl alcohol polyether-12, (a3) 1.0-5.0% by weight of glyceryl stearate, (a4) 0.01-1.0% by weight of cetearyl alcohol, (a5) 0.35-0.75% by weight of cetyl palmitate, (a6) 0.7-1.5% by weight of cetearyl alcohol polyether-20, (a7) 0.01-1.0% by weight of potassium cetyl phosphate and / or sodium cetyl phosphate, (a8) 0-0.5% by weight of preservatives, such as sodium benzoate. (a9) 0.05-0.5% by weight of lactic acid or its salt, (a10) 10.0-30.0% by weight of glycerol, and (a11) 40.0-60.0% by weight of water, The respective weight percentages of (a1) to (a11) are based on the total weight of (a1) to (a11); and (b) One or more thickeners.

2. The scalp protection composition according to claim 1, wherein the nanoemulsion is prepared from a mixture of the following components: (a1) 12.0-18.0% by weight of myristyl myristate, (a2) 7.5-10.0% by weight of cetearyl alcohol polyether-12, (a3) 1.1-4.9% by weight of glyceryl stearate, (a4) 0.05-0.9% by weight of cetearyl alcohol, (a5) 0.38-0.70% by weight of cetyl palmitate, (a6) 0.8-1.4% by weight of cetearyl alcohol polyether-20, (a7) 0.02-0.8% by weight of potassium cetyl phosphate and / or sodium cetyl phosphate, (a8) 0.1-0.4% by weight of a preservative, such as sodium benzoate. (a9) 0.1-0.5% by weight of lactic acid or its salt, (a10) 15.0-25.0% by weight of glycerol, and (a11) 45.0-55.0% by weight of water, The weight percentages of (a1) to (a11) are based on the total weight of (a1) to (a11).

3. The scalp protection composition according to claim 1 or 2, wherein the nanoemulsion is prepared by high shear stirring, phase transition temperature (PIT) method or phase transition composition (PIC) method, preferably by phase transition temperature (PIT) method.

4. The scalp protection composition according to claim 3, wherein the phase transition temperature (PIT) method comprises: - Mix components (a1) to (a11) together at room temperature to form a homogeneous mixture, then heat the mixture to above 75°C but preferably below 100°C, and then rapidly cool the heated mixture to room temperature, for example by an ice bath; - Alternatively, a mixture of some components such as (a1) to (a6) and a mixture of other components such as (a7) to (a11) are heated separately to above 75°C but preferably below 100°C, and then mixed together while maintaining the temperature. The heated mixture is then rapidly cooled to room temperature, for example by an ice bath. - Alternatively, heat (a1) to (a11) separately to above 75°C but preferably below 100°C, then mix them together while maintaining the temperature, and then rapidly cool the heated mixture to room temperature, for example by an ice bath; The above steps are preferably carried out under stirring.

5. The scalp protection composition according to any one of claims 1 to 4, wherein the microdroplets in the nanoemulsion have an average particle size of 20-500 nm, more preferably 20-300 nm.

6. The scalp protection composition according to any one of claims 1 to 5, wherein the nanoemulsion has a Zeta potential greater than 20 mV at room temperature, preferably greater than 30 mV at room temperature, for example, 20-50 mV at room temperature.

7. The scalp protection composition according to any one of claims 1 to 6, wherein the nanoemulsion is present in the scalp protection composition at a content of 4-20% by weight, preferably 5-15% by weight, based on the total weight of the scalp protection composition.

8. The scalp protection composition according to any one of claims 1 to 7, wherein the thickener is selected from: - Nonionic thickeners, such as polyacrylamide polymers, cross-linked poly(N-vinylpyrrolidone), polysaccharides, natural or synthetic gums or polysaccharides, polyvinylpyrrolidone and polyvinyl alcohol; - Anionic thickeners, such as acrylic / ethyl acrylate copolymers, carboxyvinyl polymers, and crosslinked copolymers of alkyl vinyl ethers and maleic anhydride; - Polysaccharides, such as cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof; - Natural gums, such as gum arabic, agar, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimethylammonium chloride, hydroxypropyl chitosan, hydroxypropyl guar gum, black privet gum, brown algin, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

9. The scalp protection composition according to any one of claims 1 to 8, wherein the thickener is present in the scalp protection composition at a content of 0.01-5% by weight, preferably 0.1-4% by weight, based on the total weight of the scalp protection composition.

10. The scalp protection composition according to any one of claims 1 to 9, wherein the scalp protection composition further comprises one or more additives, preferably selected from panthenol, allantoin, pH adjusters, chelating agents and preservatives.

11. The scalp protection composition according to any one of claims 1 to 10, wherein the pH range of the scalp protection composition is 4-8, preferably 5-7.

5.

12. The scalp protection composition according to any one of claims 1 to 11, wherein the water content of the scalp protection composition is not less than 75% by weight, more preferably 80-97% by weight, based on the total weight of the scalp protection composition.

13. A method for preparing the scalp protection composition according to any one of claims 1 to 12, comprising: (i) The nanoemulsion is prepared from components (a1) to (a11) by high shear stirring, phase transition temperature (PIT) method or phase transition composition (PIC) method, preferably by phase transition temperature (PIT) method; (ii) The nanoemulsion is mixed with component (b) and water by stirring to form a homogeneous mixture.

14. Use of the scalp protection composition according to any one of claims 1 to 12 for protecting the scalp before hair dyeing or perming.

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